Staphylococcus aureus (DSM 11822, ICB 25701)
Staphylococcus aureus DSM 11822 is a human pathogen that has multiple antibiotic resistances and was isolated from clinical material.
antibiotic resistance human pathogen BacteriaName and taxonomic classification
| @ref 20215 |
Last LPSN update
2026-05-29 08:28:17 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Caryophanales |
| Family Staphylococcaceae |
| Genus Staphylococcus |
| Species Staphylococcus aureus |
| Full scientific name Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980) |
| Synonyms (2) |
Culture and growth conditions
Culture medium
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 4503 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive  | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 4503 | TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) | Medium recipe at MediaDive | Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water |
Culture temp
| @ref | Growth | Type | Temperature (°C) | |
|---|---|---|---|---|
| 4503 | positive | growth | 37 |
Physiology and metabolism
Antibiotic susceptibility testing
| Test 1 | Test 2 | Test 3 | Test 4 | Test 5 | Test 6 | |
|---|---|---|---|---|---|---|
| @ref | 4503 | 4503 | 4503 | 4503 | 4503 | 4503 |
| Medium | Mueller-Hinton Agar | Mueller-Hinton Agar | Mueller-Hinton Agar | Mueller-Hinton Agar | Mueller-Hinton Agar | Mueller-Hinton Agar |
| Manual annotation | 1 | 1 | 1 | 1 | 1 | 1 |
| Inhibition zone diameter in mm | Inhibition zone diameter in mm | Inhibition zone diameter in mm | Inhibition zone diameter in mm | Inhibition zone diameter in mm | Inhibition zone diameter in mm | |
| Amikacin 30µg (disc) | 12 | 12 | 10-12 | 10-12 | 12-14 | 12-14 |
| Ampicillin 10µg (disc) | 10 | 12 | 10 | 10-12 | 10-12 | 10-12 |
| Aztreonam 30µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Bacitracin 10Unit | 30 | 32-34 | 28 | 26-28 | 26 | 26 |
| Cefalotin 30µg (disc) | 26 | 28-30 | 26-28 | 24-26 | 24 | 24 |
| Cefazolin 30µg (disc) | 20 | 20 | 16-18 | 16 | 20 | 20 |
| Cefotaxime 30µg (disc) | 12 | 10 | 12 | 12 | 12-14 | 12-14 |
| Ceftriaxone 30µg (disc) | 10 | 10 | n.d. | n.d. | 12 | 12 |
| Chloramphenicol 30µg (disc) | 8 | 10 | 8-10 | 10 | 8 | 8 |
| Clindamycin 10µg (disc) | 0 | 0 | n.d. | n.d. | 0 | 0 |
| Colistin 10µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Doxycycline 30µg (disc) | 16 | 18-20 | 18-20 | 20 | 18 | 18 |
| Erythromycin 15µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Fosfomycin 50µg (disc) | 34 | 34-36 | n.d. | n.d. | 32 | 32 |
| Gentamicin 10µg (disc) | 6 | 0 | 0 | 0 | 6 | 6 |
| Imipenem 10µg (disc) | 32-34 | 32-34 | 24 | 30-32 | 32-34 | 32-34 |
| Kanamycin 30µg (disc) | 0 | 8 | 0 | 0 | 0 | 0 |
| Lincomycin 15µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Linezolid 10µg (disc) | 34 | 30-32 | n.d. | n.d. | 32 | 32 |
| Mezlocillin 30µg (disc) | 10-12 | 10-12 | 10 | 10-12 | 10 | 10 |
| Moxifloxacin 5µg (disc) | 20 | 18-20 | n.d. | n.d. | 18 | 18 |
| Neomycin 30µg (disc) | 12-14 | 14 | 12 | 14 | 16 | 16 |
| Nitrofurantoin 100µg (disc) | 22 | 22 | 22 | 22 | 20-22 | 20-22 |
| Norfloxacin 10µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Nystatin 100Unit | 0 | 0 | n.d. | n.d. | 0 | 0 |
| Ofloxacin 5µg (disc) | 8 | 8-10 | 8-10 | 10-12 | 8 | 8 |
| Oxacillin 5µg (disc) | 0 | 0 | 0 | 0 | 18 | 18 |
| Penicillin G 6µg (disc) | 8 | 10 | 10 | 10 | 8-10 | 8-10 |
| Pipemidic acid 20µg (disc) | 0 | 0 | 0 | 0 | 0 | 0 |
| Piperacillin/Tazobactam 40µg (disc) | 20 | 18 | n.d. | n.d. | 20 | 20 |
| Polymyxin B 300Unit | 10 | 10 | 10 | 10 | 8-10 | 8-10 |
| Quinupristin/Dalfopristin 15µg (disc) | 26 | 28-30 | n.d. | n.d. | 26 | 26 |
| Teicoplanin 30µg (disc) | 18 | 18-20 | n.d. | n.d. | 16 | 16 |
| Tetracycline 30µg (disc) | 12 | 12 | 12-14 | 14 | 12 | 12 |
| Ticarcillin 75µg (disc) | 16 | 14 | 14-16 | 16-18 | 18 | 18 |
| Vancomycin 30µg (disc) | 20 | 20 | 20-22 | 20 | 18 | 18 |
Observation
| 4503 | ObservationMRSA |
Metabolite utilization
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68375 | 22599 ChEBI | arabinose | - | fermentation | from API ID32STA |
| 68375 | 29016 ChEBI | arginine | + | hydrolysis | from API ID32STA |
| 68375 | 17057 ChEBI | cellobiose | - | fermentation | from API ID32STA |
| 68375 | 15824 ChEBI | D-fructose | + | fermentation | from API ID32STA |
| 68375 | 17634 ChEBI | D-glucose | + | fermentation | from API ID32STA |
| 68375 | 16899 ChEBI | D-mannitol | + | fermentation | from API ID32STA |
| 68375 | 16024 ChEBI | D-mannose | + | fermentation | from API ID32STA |
| 68375 | 16988 ChEBI | D-ribose | - | fermentation | from API ID32STA |
| 68375 | 4853 ChEBI | esculin | - | hydrolysis | from API ID32STA |
| 68375 | 17716 ChEBI | lactose | + | fermentation | from API ID32STA |
| 68375 | 17306 ChEBI | maltose | + | fermentation | from API ID32STA |
| 68375 | 59640 ChEBI | N-acetylglucosamine | + | fermentation | from API ID32STA |
| 68375 | 17632 ChEBI | nitrate | + | reduction | from API ID32STA |
| 68375 | 18257 ChEBI | ornithine | - | degradation | from API ID32STA |
| 68375 | 16634 ChEBI | raffinose | - | fermentation | from API ID32STA |
| 68375 | 17992 ChEBI | sucrose | + | fermentation | from API ID32STA |
| 68375 | 27082 ChEBI | trehalose | + | fermentation | from API ID32STA |
| 68375 | 32528 ChEBI | turanose | + | fermentation | from API ID32STA |
Antibiotic resistance
| @ref | ChEBI | Metabolite | Is resistant | Resistance conc. | |
|---|---|---|---|---|---|
| 4503 | 161680 | Aztreonam | 30 µg (disc) | from Antibiotic test | |
| 4503 | 3745 | Clindamycin | 10 µg (disc) | from Antibiotic test | |
| 4503 | 37943 | Colistin | 10 µg (disc) | from Antibiotic test | |
| 4503 | 48923 | Erythromycin | 15 µg (disc) | from Antibiotic test | |
| 4503 | 6472 | Lincomycin | 15 µg (disc) | from Antibiotic test | |
| 4503 | 100246 | Norfloxacin | 10 µg (disc) | from Antibiotic test | |
| 4503 | 7660 | Nystatin | 100 Unit | from Antibiotic test | |
| 4503 | 75250 | Pipemidic acid | 20 µg (disc) | from Antibiotic test |
Metabolite production
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | from API ID32STA |
Metabolite tests
| @ref | Chebi-ID | Metabolite | Voges-proskauer-test | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | + | from API ID32STA |
Enzymes
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68375 | alkaline phosphatase | + | 3.1.3.1 | from API ID32STA |
| 68375 | arginine dihydrolase | + | 3.5.3.6 | from API ID32STA |
| 68375 | beta-galactosidase | - | 3.2.1.23 | from API ID32STA |
| 68375 | beta-glucosidase | - | 3.2.1.21 | from API ID32STA |
| 68375 | beta-glucuronidase | - | 3.2.1.31 | from API ID32STA |
| 4503 | catalase | + | 1.11.1.6 | |
| 4503 | cytochrome-c oxidase | - | 1.9.3.1 | |
| 68375 | L-arginine arylamidase | - | from API ID32STA | |
| 68375 | ornithine decarboxylase | - | 4.1.1.17 | from API ID32STA |
API ID32STA
| @ref | URE | ADH (Arg) | ODC | ESC | GLU | FRU | MNE | MAL | LAC | TRE | MAN | RAF | RIB | CEL | Reduction of nitrateNIT | Acetoin production (Voges Proskauer test)VP | beta GAL | L-arginine arylamidaseArgA | PAL | Pyrrolidonyl arylamidasePyrA | NOVO | SAC | NAG | TUR | ARA | beta GUR | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4503 | - | + | - | - | + | + | + | + | not determinedn.d. | + | + | - | - | - | + | + | - | - | + | - | - | + | + | + | - | - | |
| 4503 | + | + | - | - | + | + | + | + | + | + | + | - | - | - | + | + | - | - | + | - | - | + | + | + | - | - | |
| 4503 | + | + | - | - | + | + | + | + | + | + | + | - | - | - | + | + | - | - | + | +/- | - | + | + | + | - | - | |
| 4503 | - | + | - | - | + | + | + | + | + | + | + | - | - | - | + | + | - | - | + | + | + | + | + | + | - | - |
Literature
Literature 
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Saarvienin A-A Novel Glycopeptide with Potent Activity against Drug-Resistant Bacteria. | Kaur A, Guerrero-Garzon JF, Rasheed S, Zehl M, Fries F, Morgenstern B, Zotchev SB, Muller R. | Angew Chem Int Ed Engl | 10.1002/anie.202425588 | 2025 | | |
| Laser-assisted microbial culturomics. | Qu T, Koch L, Mukherjee R, Tu Y, Seidel AL, Puttmann LD, Winkel A, Yang I, Grischke J, Liu D, Wolkers WF, Kittler S, Chichkov B, Stiesch M, Szafranski SP. | Nat Commun | 10.1038/s41467-025-66804-7 | 2025 | | |
| Biotechnology | Validation of the Peel Plate Staphylococcus Aureus (SA) Test for Enumeration of S. aureus in Selected Foods and Non-Cultured Dairy Products: AOAC Performance Tested MethodSM 082401. | Salter RS, Durbin GW, Li S, Gilbert M, Crowley ES, Deterding A, Bastin B. | J AOAC Int | 10.1093/jaoacint/qsae083 | 2025 | |
| Gold(i) and gold(iii) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity. | Mahdavi SM, Bockfeld D, Esarev IV, Lippmann P, Frank R, Bronstrup M, Ott I, Tamm M. | RSC Med Chem | 10.1039/d4md00358f | 2024 | | |
| Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models. | Zwicker P, Schleusener J, Lohan SB, Busch L, Sicher C, Einfeldt S, Kneissl M, Kuhl AA, Keck CM, Witzel C, Kramer A, Meinke MC. | Sci Rep | 10.1038/s41598-022-06397-z | 2022 | | |
| Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity. | Hakkinen ST, Cankar K, Nohynek L, van Arkel J, Laurel M, Oksman-Caldentey KM, Van Droogenbroeck B. | Pharmaceuticals (Basel) | 10.3390/ph16020140 | 2023 | | |
| Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs. | Glaab J, Lobo-Ploch N, Cho HK, Filler T, Gundlach H, Guttmann M, Hagedorn S, Lohan SB, Mehnke F, Schleusener J, Sicher C, Sulmoni L, Wernicke T, Wittenbecher L, Woggon U, Zwicker P, Kramer A, Meinke MC, Kneissl M, Weyers M, Winterwerber U, Einfeldt S. | Sci Rep | 10.1038/s41598-021-94070-2 | 2021 | | |
| An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile. | Bussing R, Bublitz A, Karge B, Bronstrup M, Strowig T, Ott I. | J Biol Inorg Chem | 10.1007/s00775-024-02064-y | 2024 | | |
| Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review. | Lysakova V, Krasnopolskaya L, Yarina M, Ziangirova M. | Antibiotics (Basel) | 10.3390/antibiotics13111026 | 2024 | | |
| Irradiation of human oral mucosa by 233 nm far UV-C LEDs for the safe inactivation of nosocomial pathogens. | Schleusener J, Lohan SB, Busch L, Zamudio Diaz DF, Opitz N, Sicher C, Lichtenthaler T, Danker K, Dommerich S, Filler T, Meinke MC, Zwicker P. | Sci Rep | 10.1038/s41598-023-49745-3 | 2023 | | |
| Pathogenicity | A modular synthesis of tetracyclic meroterpenoid antibiotics. | Wildermuth R, Speck K, Haut FL, Mayer P, Karge B, Bronstrup M, Magauer T. | Nat Commun | 10.1038/s41467-017-02061-7 | 2017 | |
| Microleakage of Restorative Materials Used for Temporization of Endodontic Access Cavities. | Wuersching SN, Moser L, Obermeier KT, Kollmuss M. | J Clin Med | 10.3390/jcm12144762 | 2023 | | |
| A comprehensive in vitro comparison of the biological and physicochemical properties of bioactive root canal sealers. | Wuersching SN, Diegritz C, Hickel R, Huth KC, Kollmuss M. | Clin Oral Investig | 10.1007/s00784-022-04570-2 | 2022 | | |
| Enzymology | Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects. | Esarev IV, Karge B, Zeng H, Lippmann P, Jones PG, Schrey H, Bronstrup M, Ott I. | ACS Infect Dis | 10.1021/acsinfecdis.4c00104 | 2024 | |
| Pathogenicity | Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase. | Bussing R, Karge B, Lippmann P, Jones PG, Bronstrup M, Ott I. | ChemMedChem | 10.1002/cmdc.202100381 | 2021 | |
| Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability. | Schmidt C, Karge B, Misgeld R, Prokop A, Bronstrup M, Ott I. | Medchemcomm | 10.1039/c7md00269f | 2017 | | |
| A Comprehensive Analysis of the UVC LEDs' Applications and Decontamination Capability. | Nicolau T, Gomes Filho N, Padrao J, Zille A. | Materials (Basel) | 10.3390/ma15082854 | 2022 | | |
| Metabolism | Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2. | Preisitsch M, Heiden SE, Beerbaum M, Niedermeyer TH, Schneefeld M, Herrmann J, Kumpfmuller J, Thurmer A, Neidhardt I, Wiesner C, Daniel R, Muller R, Bange FC, Schmieder P, Schweder T, Mundt S. | Mar Drugs | 10.3390/md14010021 | 2016 | |
How to cite
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive14461.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain dataIsabel Schober, Julia Koblitz, Joaquim Sardà Carbasse, Christian Ebeling, Marvin Leon Schmidt, Adam Podstawka, Rohit Gupta, Vinodh Ilangovan, Javad Chamanara, Jörg Overmann, Lorenz Christian Reimer
Nucleic Acids Research; database issue 2025.
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