Staphylococcus aureus (DSM 20233, CCM 2571, H)
Staphylococcus aureus H is a human pathogen of the family Staphylococcaceae.
human pathogen BacteriaName and taxonomic classification
| @ref 20215 |
Last LPSN update
2026-05-29 08:28:18 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Caryophanales |
| Family Staphylococcaceae |
| Genus Staphylococcus |
| Species Staphylococcus aureus |
| Full scientific name Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980) |
| Synonyms (2) |
Culture and growth conditions
Culture medium
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 8648 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive  | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 8648 | TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) | Medium recipe at MediaDive | Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water |
Culture temp
| @ref | Growth | Type | Temperature (°C) | |
|---|---|---|---|---|
| 8648 | positive | growth | 37 |
Physiology and metabolism
Metabolite utilization
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68375 | 22599 ChEBI | arabinose | - | fermentation | from API ID32STA |
| 68375 | 29016 ChEBI | arginine | + | hydrolysis | from API ID32STA |
| 68375 | 17057 ChEBI | cellobiose | - | fermentation | from API ID32STA |
| 68375 | 15824 ChEBI | D-fructose | + | fermentation | from API ID32STA |
| 68375 | 17634 ChEBI | D-glucose | + | fermentation | from API ID32STA |
| 68375 | 16899 ChEBI | D-mannitol | + | fermentation | from API ID32STA |
| 68375 | 16024 ChEBI | D-mannose | + | fermentation | from API ID32STA |
| 68375 | 16988 ChEBI | D-ribose | - | fermentation | from API ID32STA |
| 68375 | 4853 ChEBI | esculin | - | hydrolysis | from API ID32STA |
| 68375 | 17716 ChEBI | lactose | + | fermentation | from API ID32STA |
| 68375 | 17306 ChEBI | maltose | + | fermentation | from API ID32STA |
| 68375 | 59640 ChEBI | N-acetylglucosamine | + | fermentation | from API ID32STA |
| 68375 | 17632 ChEBI | nitrate | + | reduction | from API ID32STA |
| 68375 | 18257 ChEBI | ornithine | - | degradation | from API ID32STA |
| 68375 | 16634 ChEBI | raffinose | - | fermentation | from API ID32STA |
| 68375 | 17992 ChEBI | sucrose | + | fermentation | from API ID32STA |
| 68375 | 27082 ChEBI | trehalose | + | fermentation | from API ID32STA |
| 68375 | 32528 ChEBI | turanose | + | fermentation | from API ID32STA |
| 68375 | 16199 ChEBI | urea | + | hydrolysis | from API ID32STA |
Antibiotic resistance
| @ref | ChEBI | Group ID | Metabolite | Is sensitive | Sensitivity conc. | |
|---|---|---|---|---|---|---|
| 68375 | 28368 | 0 | novobiocin | 1.8 µg | from API ID32STA |
Metabolite production
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | from API ID32STA |
Metabolite tests
| @ref | Chebi-ID | Metabolite | Voges-proskauer-test | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | + | from API ID32STA |
Enzymes
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68375 | alkaline phosphatase | + | 3.1.3.1 | from API ID32STA |
| 68375 | arginine dihydrolase | + | 3.5.3.6 | from API ID32STA |
| 68375 | beta-galactosidase | - | 3.2.1.23 | from API ID32STA |
| 68375 | beta-glucosidase | - | 3.2.1.21 | from API ID32STA |
| 68375 | beta-glucuronidase | - | 3.2.1.31 | from API ID32STA |
| 68375 | L-arginine arylamidase | - | from API ID32STA | |
| 68375 | ornithine decarboxylase | - | 4.1.1.17 | from API ID32STA |
| 68375 | pyrrolidonyl arylamidase | + | 3.4.19.3 | from API ID32STA |
| 68375 | urease | + | 3.5.1.5 | from API ID32STA |
Literature
Literature 
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia. | Kerkman PF, de Vor L, van der Vaart TW, Ten Doesschate T, Muts RM, Depelteau JS, Scheepmaker LM, Ruyken M, de Haas CJC, Aerts PC, Marijnissen RJ, Schuurman J, Beurskens FJ, Gorlani A, Bardoel BW, Rooijakkers SHM. | J Immunol | 10.4049/jimmunol.2300858 | 2024 | | |
| Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model. | Beudeker CR, van Dalen R, Ruyken M, de Haas CJC, Scheepmaker LM, Vijlbrief D, Lely AT, van Kessel KPM, van der Bruggen JT, Rooijakkers SHM, Salazar LA, van der Flier M. | Sci Rep | 10.1038/s41598-025-15490-y | 2025 | | |
| The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients. | Hilton KLF, Manwani C, Boles JE, White LJ, Ozturk S, Garrett MD, Hiscock JR, Hiscock JR. | Chem Sci | 10.1039/d1sc03597e | 2021 | | |
| Metabolism | Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus. | Kho K, Meredith TC. | J Bacteriol | 10.1128/jb.00017-18 | 2018 | |
| Systematic review of membrane components of gram-positive bacteria responsible as pyrogens for inducing human monocyte/macrophage cytokine release. | Rockel C, Hartung T. | Front Pharmacol | 10.3389/fphar.2012.00056 | 2012 | | |
| Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria. | Shiraishi T, Yokota S, Fukiya S, Yokota A. | Biosci Microbiota Food Health | 10.12938/bmfh.2016-006 | 2016 | | |
| Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation. | Ahn KB, Baik JE, Yun CH, Han SH. | Front Microbiol | 10.3389/fmicb.2018.00327 | 2018 | | |
| Metabolism | Beta-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes. | Lotz S, Starke A, Ziemann C, Morath S, Hartung T, Solbach W, Laskay T. | Ann Clin Microbiol Antimicrob | 10.1186/1476-0711-5-15 | 2006 | |
| Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression. | von Aulock S, Rupp J, Gueinzius K, Maass M, Hermann C. | Clin Diagn Lab Immunol | 10.1128/cdli.12.10.1254-1256.2005 | 2005 | | |
| Metabolism | Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. | von Aulock S, Schroder NW, Traub S, Gueinzius K, Lorenz E, Hartung T, Schumann RR, Hermann C. | Infect Immun | 10.1128/iai.72.3.1828-1831.2004 | 2004 | |
| Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. | Poehlmann H, Schefold JC, Zuckermann-Becker H, Volk HD, Meisel C. | Crit Care | 10.1186/cc7969 | 2009 | | |
| Pathogenicity | Use of synthetic derivatives to determine the minimal active structure of cytokine-inducing lipoteichoic acid. | Deininger S, Figueroa-Perez I, Sigel S, Stadelmaier A, Schmidt RR, Hartung T, von Aulock S. | Clin Vaccine Immunol | 10.1128/cvi.00007-07 | 2007 | |
| Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. | Morath S, Geyer A, Hartung T. | J Exp Med | 10.1084/jem.193.3.393 | 2001 | | |
| Characterization of lipoteichoic acid structures from three probiotic Bacillus strains: involvement of D-alanine in their biological activity. | Villeger R, Saad N, Grenier K, Falourd X, Foucat L, Urdaci MC, Bressollier P, Ouk TS. | Antonie Van Leeuwenhoek | 10.1007/s10482-014-0239-8 | 2014 | | |
| Metabolism | Influence of lipoteichoic acid structure on recognition by the macrophage scavenger receptor. | Greenberg JW, Fischer W, Joiner KA. | Infect Immun | 10.1128/iai.64.8.3318-3325.1996 | 1996 | |
| Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations. | Morath S, Geyer A, Spreitzer I, Hermann C, Hartung T. | Infect Immun | 10.1128/iai.70.2.938-944.2002 | 2002 | | |
| Effect of lipoteichoic acid on thermotropic membrane properties. | Gutberlet T, Frank J, Bradaczek H, Fischer W. | J Bacteriol | 10.1128/jb.179.9.2879-2883.1997 | 1997 | | |
| Metabolism | Interactions of human mannose-binding protein with lipoteichoic acids. | Polotsky VY, Fischer W, Ezekowitz RA, Joiner KA. | Infect Immun | 10.1128/iai.64.1.380-383.1996 | 1996 | |
| Enzymology | Effect of alanine ester substitution and other structural features of lipoteichoic acids on their inhibitory activity against autolysins of Staphylococcus aureus. | Fischer W, Rosel P, Koch HU. | J Bacteriol | 10.1128/jb.146.2.467-475.1981 | 1981 | |
| Metabolism | Role of nitric oxide in the circulatory failure and organ injury in a rodent model of gram-positive shock. | Kengatharan KM, De Kimpe SJ, Thiemermann C. | Br J Pharmacol | 10.1111/j.1476-5381.1996.tb16053.x | 1996 | |
| Stimulation of monokine production by lipoteichoic acids. | Bhakdi S, Klonisch T, Nuber P, Fischer W. | Infect Immun | 10.1128/iai.59.12.4614-4620.1991 | 1991 | | |
| Pathogenicity | Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids. | Keller R, Fischer W, Keist R, Bassetti S. | Infect Immun | 10.1128/iai.60.9.3664-3672.1992 | 1992 | |
| Pathogenicity | Interaction of purified lipoteichoic acid with the classical complement pathway. | Loos M, Clas F, Fischer W. | Infect Immun | 10.1128/iai.53.3.595-599.1986 | 1986 | |
| Pathogenicity | Development of a fluorescence assay for the detection of L-ficolin-MASP in serum or purified samples. | Gulla KC, Gupta K, Gupta RK, Vyas V, Hajela K | J Biochem Biophys Methods | 10.1016/j.jbbm.2005.12.001 | 2006 | |
How to cite
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive14489.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain dataIsabel Schober, Julia Koblitz, Joaquim Sardà Carbasse, Christian Ebeling, Marvin Leon Schmidt, Adam Podstawka, Rohit Gupta, Vinodh Ilangovan, Javad Chamanara, Jörg Overmann, Lorenz Christian Reimer
Nucleic Acids Research; database issue 2025.
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