Staphylococcus aureus (CCUG 10777, NCTC 4163)
Staphylococcus aureus CCUG 10777 is a bacterium of the family Staphylococcaceae.
genome sequence BacteriaName and taxonomic classification
| @ref 20215 |
Last LPSN update
2026-05-29 08:40:07 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Caryophanales |
| Family Staphylococcaceae |
| Genus Staphylococcus |
| Species Staphylococcus aureus |
| Full scientific name Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980) |
| Synonyms (2) |
Physiology and metabolism
Oxygen tolerance
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | facultative anaerobe | 96.634 |
Spore formation
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 97.372 |
Metabolite utilization
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68375 | 22599 ChEBI | arabinose | - | fermentation | from API ID32STA |
| 68375 | 29016 ChEBI | arginine | + | hydrolysis | from API ID32STA |
| 68375 | 17057 ChEBI | cellobiose | - | fermentation | from API ID32STA |
| 68375 | 15824 ChEBI | D-fructose | + | fermentation | from API ID32STA |
| 68379 | 17634 ChEBI | D-glucose | + | fermentation | from API Coryne |
| 68375 | 17634 ChEBI | D-glucose | + | fermentation | from API ID32STA |
| 68379 | 16899 ChEBI | D-mannitol | + | fermentation | from API Coryne |
| 68375 | 16899 ChEBI | D-mannitol | + | fermentation | from API ID32STA |
| 68375 | 16024 ChEBI | D-mannose | + | fermentation | from API ID32STA |
| 68379 | 16988 ChEBI | D-ribose | + | fermentation | from API Coryne |
| 68375 | 16988 ChEBI | D-ribose | - | fermentation | from API ID32STA |
| 68379 | 65327 ChEBI | D-xylose | - | fermentation | from API Coryne |
| 68379 | 4853 ChEBI | esculin | - | hydrolysis | from API Coryne |
| 68375 | 4853 ChEBI | esculin | - | hydrolysis | from API ID32STA |
| 68379 | 5291 ChEBI | gelatin | + | hydrolysis | from API Coryne |
| 68379 | 28087 ChEBI | glycogen | - | fermentation | from API Coryne |
| 68379 | 17716 ChEBI | lactose | + | fermentation | from API Coryne |
| 68375 | 17716 ChEBI | lactose | + | fermentation | from API ID32STA |
| 68379 | 17306 ChEBI | maltose | + | fermentation | from API Coryne |
| 68375 | 17306 ChEBI | maltose | + | fermentation | from API ID32STA |
| 68375 | 59640 ChEBI | N-acetylglucosamine | + | fermentation | from API ID32STA |
| 68379 | 17632 ChEBI | nitrate | + | reduction | from API Coryne |
| 68375 | 17632 ChEBI | nitrate | + | reduction | from API ID32STA |
| 68375 | 18257 ChEBI | ornithine | - | degradation | from API ID32STA |
| 68375 | 16634 ChEBI | raffinose | - | fermentation | from API ID32STA |
| 68379 | 17992 ChEBI | sucrose | + | fermentation | from API Coryne |
| 68375 | 17992 ChEBI | sucrose | + | fermentation | from API ID32STA |
| 68375 | 27082 ChEBI | trehalose | + | fermentation | from API ID32STA |
| 68375 | 32528 ChEBI | turanose | - | fermentation | from API ID32STA |
| 68379 | 16199 ChEBI | urea | + | hydrolysis | from API Coryne |
| 68375 | 16199 ChEBI | urea | + | hydrolysis | from API ID32STA |
Antibiotic resistance
| @ref | ChEBI | Group ID | Metabolite | Is sensitive | Sensitivity conc. | |
|---|---|---|---|---|---|---|
| 68375 | 28368 | 0 | novobiocin | 1.8 µg | from API ID32STA |
Metabolite production
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | from API ID32STA |
Metabolite tests
| @ref | Chebi-ID | Metabolite | Voges-proskauer-test | |
|---|---|---|---|---|
| 68375 | 15688 ChEBI | acetoin | + | from API ID32STA |
Enzymes
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68375 | alkaline phosphatase | + | 3.1.3.1 | from API ID32STA |
| 68379 | alkaline phosphatase | + | 3.1.3.1 | from API Coryne |
| 68379 | alpha-glucosidase | + | 3.2.1.20 | from API Coryne |
| 68375 | arginine dihydrolase | + | 3.5.3.6 | from API ID32STA |
| 68375 | beta-galactosidase | - | 3.2.1.23 | from API ID32STA |
| 68379 | beta-galactosidase | - | 3.2.1.23 | from API Coryne |
| 68379 | beta-glucosidase | - | 3.2.1.21 | from API Coryne |
| 68375 | beta-glucosidase | - | 3.2.1.21 | from API ID32STA |
| 68375 | beta-glucuronidase | - | 3.2.1.31 | from API ID32STA |
| 68379 | beta-glucuronidase | - | 3.2.1.31 | from API Coryne |
| 68379 | catalase | + | 1.11.1.6 | from API Coryne |
| 68379 | gelatinase | + | from API Coryne | |
| 68375 | L-arginine arylamidase | - | from API ID32STA | |
| 68379 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API Coryne |
| 68375 | ornithine decarboxylase | - | 4.1.1.17 | from API ID32STA |
| 68379 | pyrazinamidase | - | 3.5.1.B15 | from API Coryne |
| 68375 | pyrrolidonyl arylamidase | + | 3.4.19.3 | from API ID32STA |
| 68379 | pyrrolidonyl arylamidase | + | 3.4.19.3 | from API Coryne |
| 68375 | urease | + | 3.5.1.5 | from API ID32STA |
| 68379 | urease | + | 3.5.1.5 | from API Coryne |
Sequence information
Genome sequences
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 66792 | 3012STDY6191362 assembly for Staphylococcus aureus NCTC4163 | complete | GCA_900635505   | 1280.19118  | 1280 | 98.7 | |
Genome browser: GCA_900635505
Literature
Literature 
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| The Importance of Substituent Position for Antibacterial Activity in the Group of Thiosemicarbazide Derivatives. | Janowska S, Stefanska J, Khylyuk D, Wujec M. | Molecules | 10.3390/molecules29061333 | 2024 | | |
| In Vitro Evaluation of Candida spp. and Staphylococcus aureus Sensitivity to 450 nm Diode Laser-Mediated Antimicrobial Photodynamic Therapy with Curcumin and Riboflavin. | Tkaczyk M, Mertas A, Kuska-Kielbratowska A, Fiegler-Rudol J, Bobela E, Cisowska M, Morawiec T, Skaba D, Wiench R. | Int J Mol Sci | 10.3390/ijms26125645 | 2025 | | |
| Quaternized Curcumin Derivative-Synthesis, Physicochemical Characteristics, and Photocytotoxicity, Including Antibacterial Activity after Irradiation with Blue Light. | Bakun P, Wysocki M, Stachowiak M, Musielak M, Dlugaszewska J, Mlynarczyk DT, Sobotta L, Suchorska WM, Goslinski T. | Molecules | 10.3390/molecules29194536 | 2024 | | |
| Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives. | Wolska A, Drzewiecka-Antonik A, Barboza CA, Struga M, Stefanska J, Rejmak P, Klepka M. | Molecules | 10.3390/molecules29214993 | 2024 | | |
| New Derivatives of 1-(3-Methyl-1-Benzofuran-2-yl)Ethan-1-one: Synthesis and Preliminary Studies of Biological Activity. | Napiorkowska M, Kumaravel P, Amboo Mahentheran M, Kiernozek-Kalinska E, Grosicka-Maciag E. | Int J Mol Sci | 10.3390/ijms25041999 | 2024 | | |
| Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives. | Drzewiecka-Antonik A, Struga M, Glogowska A, Augustynowicz-Kopec E, Dobrzynska K, Chrzanowska A, Wolska A, Rejmak P, Klepka MT, Wrzosek M, Bielenica A. | Int J Mol Sci | 10.3390/ijms232415694 | 2022 | | |
| Enzymology | Novel Tetrazole-Based Antimicrobial Agents Targeting Clinical Bacteria Strains: Exploring the Inhibition of Staphylococcus aureus DNA Topoisomerase IV and Gyrase. | Roszkowski P, Szymanska-Majchrzak J, Kolinski M, Kmiecik S, Wrzosek M, Struga M, Szulczyk D. | Int J Mol Sci | 10.3390/ijms23010378 | 2021 | |
| Design and Synthesis of Menthol and Thymol Derived Ciprofloxacin: Influence of Structural Modifications on the Antibacterial Activity and Anticancer Properties. | Szostek T, Szulczyk D, Szymanska-Majchrzak J, Kolinski M, Kmiecik S, Otto-Slusarczyk D, Zawodnik A, Rajkowska E, Chaniewicz K, Struga M, Roszkowski P. | Int J Mol Sci | 10.3390/ijms23126600 | 2022 | | |
| New Metallophthalocyanines Bearing 2-Methylimidazole Moieties-Potential Photosensitizers against Staphylococcus aureus. | Wierzchowski M, Ziental D, Lazewski D, Korzanski A, Gielara-Korzanska A, Tykarska E, Dlugaszewska J, Sobotta L. | Int J Mol Sci | 10.3390/ijms23115910 | 2022 | | |
| Synthetic Transition from Thiourea-Based Compounds to Tetrazole Derivatives: Structure and Biological Evaluation of Synthesized New N-(Furan-2-ylmethyl)-1H-tetrazol-5-amine Derivatives. | Szulczyk D, Bielenica A, Roszkowski P, Dobrowolski MA, Olejarz W, Kmiecik S, Podsiad M, Struga M. | Molecules | 10.3390/molecules26020323 | 2021 | | |
| Structure-Activity Relationship of New Chimeric Analogs of Mastoparan from the Wasp Venom Paravespula lewisii. | Ruczynski J, Parfianowicz B, Mucha P, Wisniewska K, Piechowicz L, Rekowski P. | Int J Mol Sci | 10.3390/ijms23158269 | 2022 | | |
| Pathogenicity | The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells. | Chrzanowska A, Drzewiecka-Antonik A, Dobrzynska K, Stefanska J, Pietrzyk P, Struga M, Bielenica A. | Int J Mol Sci | 10.3390/ijms222111415 | 2021 | |
| Fluoroquinolones' Biological Activities against Laboratory Microbes and Cancer Cell Lines. | Suaifan GARY, Mohammed AAM, Alkhawaja BA. | Molecules | 10.3390/molecules27051658 | 2022 | | |
| N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents. | Struga M, Roszkowski P, Bielenica A, Otto-Slusarczyk D, Stepien K, Stefanska J, Zabost A, Augustynowicz-Kopec E, Kolinski M, Kmiecik S, Myslovska A, Wrzosek M. | ACS Omega | 10.1021/acsomega.3c00554 | 2023 | | |
| Antimicrobial activity of the biogenically synthesized core-shell Cu@Pt nanoparticles. | Dobrucka R, Dlugaszewska J. | Saudi Pharm J | 10.1016/j.jsps.2018.02.028 | 2018 | | |
| Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies. | Bielenica A, Sanna G, Madeddu S, Giliberti G, Stefanska J, Koziol AE, Savchenko O, Strzyga-Lach P, Chrzanowska A, Kubiak-Tomaszewska G, Struga M. | Molecules | 10.3390/molecules23102428 | 2018 | | |
| Evaluation of biologically synthesized Au-CuO and CuO-ZnO nanoparticles against glioma cells and microorganisms. | Dobrucka R, Kaczmarek M, Lagiedo M, Kielan A, Dlugaszewska J. | Saudi Pharm J | 10.1016/j.jsps.2018.12.006 | 2019 | | |
| The Effect of Conjugation of Ciprofloxacin and Moxifloxacin with Fatty Acids on Their Antibacterial and Anticancer Activity. | Chrzanowska A, Struga M, Roszkowski P, Kolinski M, Kmiecik S, Jalbrzykowska K, Zabost A, Stefanska J, Augustynowicz-Kopec E, Wrzosek M, Bielenica A. | Int J Mol Sci | 10.3390/ijms23116261 | 2022 | | |
| Pathogenicity | Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas. | Sanna G, Madeddu S, Giliberti G, Piras S, Struga M, Wrzosek M, Kubiak-Tomaszewska G, Koziol AE, Savchenko O, Lis T, Stefanska J, Tomaszewski P, Skrzycki M, Szulczyk D. | Molecules | 10.3390/molecules23102554 | 2018 | |
| Current Knowledge of the Mode of Action and Immunity Mechanisms of LAB-Bacteriocins. | Perez-Ramos A, Madi-Moussa D, Coucheney F, Drider D. | Microorganisms | 10.3390/microorganisms9102107 | 2021 | | |
| Pathogenicity | Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms. | Halstead FD, Thwaite JE, Burt R, Laws TR, Raguse M, Moeller R, Webber MA, Oppenheim BA. | Appl Environ Microbiol | 10.1128/aem.00756-16 | 2016 | |
| Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives. | Kossakowski J, Krawiecka M, Kuran B, Stefanska J, Wolska I. | Molecules | 10.3390/molecules15074737 | 2010 | | |
| Wound healing properties and kill kinetics of Clerodendron splendens G. Don, a Ghanaian wound healing plant. | Gbedema SY, Emelia K, Francis A, Kofi A, Eric W. | Pharmacognosy Res | 10.4103/0974-8490.62948 | 2010 | | |
| Synthesis, anticancer and antibacterial activity of salinomycin N-benzyl amides. | Antoszczak M, Maj E, Napiorkowska A, Stefanska J, Augustynowicz-Kopec E, Wietrzyk J, Janczak J, Brzezinski B, Huczynski A. | Molecules | 10.3390/molecules191219435 | 2014 | | |
| Adaptive bacterial response to low level chlorhexidine exposure and its implications for hand hygiene. | Kampf G. | Microb Cell | 10.15698/mic2019.07.683 | 2019 | | |
| Pathogenicity | Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy. | Hartmann M, Berditsch M, Hawecker J, Ardakani MF, Gerthsen D, Ulrich AS. | Antimicrob Agents Chemother | 10.1128/aac.00124-10 | 2010 | |
| Pathogenicity | 1,4-Disubstituted thiosemicarbazide derivatives are potent inhibitors of Toxoplasma gondii proliferation. | Dzitko K, Paneth A, Plech T, Pawelczyk J, Staczek P, Stefanska J, Paneth P. | Molecules | 10.3390/molecules19079926 | 2014 | |
| Synthesis, Structural Studies and Biological Evaluation of Connections of Thiosemicarbazide, 1,2,4-Triazole and 1,3,4-Thiadiazole with Palmitic Acid. | Jozwiak M, Stepien K, Wrzosek M, Olejarz W, Kubiak-Tomaszewska G, Filipowska A, Filipowski W, Struga M. | Molecules | 10.3390/molecules23040822 | 2018 | | |
| Natural Products from Three Nudibranchs: Nembrotha kubaryana, Hypselodoris infucata and Chromodoris petechialis | Karuso P, Scheuer P. | Molecules | 2002 | | ||
| Pathogenicity | Development and evaluation of a chromogenic agar medium for methicillin-resistant Staphylococcus aureus. | Perry JD, Davies A, Butterworth LA, Hopley AL, Nicholson A, Gould FK. | J Clin Microbiol | 10.1128/jcm.42.10.4519-4523.2004 | 2004 | |
| Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases. | Orchard A, van Vuuren S. | Evid Based Complement Alternat Med | 10.1155/2017/4517971 | 2017 | | |
| Pathogenicity | Photodynamic disinfection and its role in controlling infectious diseases. | Aroso RT, Schaberle FA, Arnaut LG, Pereira MM. | Photochem Photobiol Sci | 10.1007/s43630-021-00102-1 | 2021 | |
| Metabolism | Antimicrobial activity and bacterial-membrane interaction of ovine-derived cathelicidins. | Anderson RC, Hancock RE, Yu PL. | Antimicrob Agents Chemother | 10.1128/aac.48.2.673-676.2004 | 2004 | |
| Pathogenicity | Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? An in vitro and in vivo assessment. | Cookson BD, Bolton MC, Platt JH. | Antimicrob Agents Chemother | 10.1128/aac.35.10.1997 | 1991 | |
| Cultivation of Staphylococcus aureus in a synthetic medium of low ultraviolet absorptivity. | Charles BG, Rawal BD. | Antimicrob Agents Chemother | 10.1128/aac.10.6.915 | 1976 | | |
| Enzymology | A flow cytometry method for rapid detection and enumeration of total bacteria in milk. | Gunasekera TS, Attfield PV, Veal DA. | Appl Environ Microbiol | 10.1128/aem.66.3.1228-1232.2000 | 2000 | |
| Observations on a new disinfectant. | Gordon AM. | J Clin Pathol | 10.1136/jcp.22.4.496 | 1969 | | |
| The antimicrobial properties of some alpha-amino-oxy-acids, alpha-amino-oxy-hydrazides, alkoxyamines, alkoxydiguanides and their derivatives. | PRICE SA, MAMALIS P, McHALE D, GREEN J. | Br J Pharmacol Chemother | 10.1111/j.1476-5381.1960.tb01238.x | 1960 | | |
| Biotechnology | The effect of two methods of cooking and cooling on Clostridium welchii and other bacteria in meat. | Sutton RG, Kendall M, Hobbs BC. | J Hyg (Lond) | 10.1017/s0022172400062999 | 1972 | |
| Pathogenicity | Effect of pH on sporicidal and microbicidal activity of buffered mixtures of alcohol and sodium hypochlorite. | Death JE, Coates D. | J Clin Pathol | 10.1136/jcp.32.2.148 | 1979 | |
| Agreement Between Deoxyribonucleic Acid Base Composition and Taxometric Classification of Gram-Positive Cocci. | Silvestri LG, Hill LR. | J Bacteriol | 10.1128/jb.90.1.136-140.1965 | 1965 | | |
| Pathogenicity | Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract. | Dobrucka R, Dlugaszewska J, Kaczmarek M | Biomed Microdevices | 10.1007/s10544-017-0233-9 | 2017 | |
| Pathogenicity | Alcohol ethoxylates mediate their bacteriostatic effect by altering the cell membrane of Escherichia coli NCTC 8196. | Moore SL, Denyer SP, Hanlon GW, Olliff CJ, Lansley AB, Rabone K, Jones M | Int J Antimicrob Agents | 10.1016/j.ijantimicag.2006.08.023 | 2006 | |
| Genetics | Investigation of morphological changes to Staphylococcus aureus induced by ovine-derived antimicrobial peptides using TEM and AFM. | Anderson RC, Haverkamp RG, Yu PL | FEMS Microbiol Lett | 10.1016/j.femsle.2004.09.027 | 2004 | |
| Enzymology | Low molecular mass peptide dendrimers that express antimicrobial properties. | Janiszewska J, Swieton J, Lipkowski AW, Urbanczyk-Lipkowska Z | Bioorg Med Chem Lett | 10.1016/j.bmcl.2003.08.009 | 2003 | |
| Pathogenicity | Synthesis and antimicrobial activity of novel pyrazole, pyrazoline, pyrazolinone and pyrazolidinedione derivatives of benzimidazole. | Soliman R, Habib NS, Ashour FA, el-Taiebi M | Boll Chim Farm | 2001 | |
How to cite
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive142100.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain dataIsabel Schober, Julia Koblitz, Joaquim Sardà Carbasse, Christian Ebeling, Marvin Leon Schmidt, Adam Podstawka, Rohit Gupta, Vinodh Ilangovan, Javad Chamanara, Jörg Overmann, Lorenz Christian Reimer
Nucleic Acids Research; database issue 2025.
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