Pathogenicity |
A comprehensive assessment of the chemical composition, antioxidant, genoprotective and antigenotoxic activities of Lamiaceae species using different experimental models in vitro. |
Oalde M, Kolarevic S, Zivkovic J, Alimpic Aradski A, Jovanovic Maric J, Kracun Kolarevic M, Dordevic J, Marin PD, Savikin K, Vukovic-Gacic B, Duletic-Lausevic S |
Food Funct |
10.1039/d1fo00447f |
2021 |
* |
Stress |
The impact of different extracts of six Lamiaceae species on deleterious effects of oxidative stress assessed in acellular, prokaryotic and eukaryotic models in vitro. |
Oalde MM, Kolarevic SM, Zivkovic JC, Vukovic-Gacic BS, Jovanovic Maric JM, Kracun Kolarevic MJ, Dordevic JZ, Alimpic Aradski AZ, Marin PD, Savikin KP, Duletic-Lausevic SN |
Saudi Pharm J |
10.1016/j.jsps.2020.10.006 |
2020 |
* |
Pathogenicity |
Antimutagenic, antigenotoxic and antiproliferative activities of Fraxinus angustifolia Vahl. leaves and stem bark extracts and their phytochemical composition. |
Bouguellid G, Russo C, Lavorgna M, Piscitelli C, Ayouni K, Wilson E, Kim HK, Verpoorte R, Choi YH, Kilani-Atmani D, Atmani D, Isidori M |
PLoS One |
10.1371/journal.pone.0230690 |
2020 |
* |
Pathogenicity |
In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient. |
Kawanishi M, Hisatomi Y, Oda Y, Shimohara C, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, Watanabe K |
J Toxicol Sci |
10.2131/jts.44.871 |
2019 |
* |
Pathogenicity |
Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models. |
Dordevic J, Kolarevic S, Jovanovic J, Kostic-Vukovic J, Novakovic I, Jeremic M, Sladic D, Vukovic-Gacic B |
Drug Chem Toxicol |
10.1080/01480545.2018.1514043 |
2018 |
* |
Pathogenicity |
In vitro Cytotoxicity and Genotoxicity Analysis of Ten Tannery Chemicals Using SOS/umu Tests and High-content In vitro Micronucleus Tests. |
Huang Z, Li N, Rao K, Liu C, Wang Z, Ma M |
Comb Chem High Throughput Screen |
10.2174/1386207321666180330120248 |
2018 |
* |
Pathogenicity |
Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. |
Kolarevic S, Milovanovic D, Kracun-Kolarevic M, Kostic J, Sunjog K, Martinovic R, Dordevic J, Novakovic I, Sladic D, Vukovic-Gacic B |
Drug Chem Toxicol |
10.1080/01480545.2017.1413108 |
2018 |
* |
Enzymology |
Antimutagenic activity of flavonoids from Sozuku. |
Okuno Y, Marumoto S, Miyazawa M |
Nat Prod Res |
10.1080/14786419.2017.1408104 |
2017 |
* |
Pathogenicity |
Development of photoprotective, antiphototoxic, and antiphotogenotoxic formulations of ocular drugs with fluoroquinolones. |
Zgadzaj A, Kornacka J, Jastrzebska A, Parzonko A, Sommer S, Nalecz-Jawecki G |
J Photochem Photobiol B |
10.1016/j.jphotobiol.2017.11.011 |
2017 |
* |
Pathogenicity |
Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ. |
Jovanovic J, Kolarevic S, Miloskovic A, Radojkovic N, Simic V, Dojcinovic B, Kracun-Kolarevic M, Paunovic M, Kostic J, Sunjog K, Timilijic J, Djordjevic J, Gacic Z, Zegura B, Vukovic-Gacic B |
Sci Total Environ |
10.1016/j.scitotenv.2017.10.099 |
2017 |
* |
Pathogenicity |
Evaluation of Genotoxic Pressure along the Sava River. |
Kolarevic S, Aborgiba M, Kracun-Kolarevic M, Kostic J, Simonovic P, Simic V, Miloskovic A, Reischer G, Farnleitner A, Gacic Z, Milacic R, Zuliani T, Vidmar J, Pergal M, Piria M, Paunovic M, Vukovic-Gacic B |
PLoS One |
10.1371/journal.pone.0162450 |
2016 |
* |
Pathogenicity |
Evaluation of genotoxic potential throughout the upper and middle stretches of Adige river basin. |
Kracun-Kolarevic M, Kolarevic S, Jovanovic J, Markovic V, Ilic M, Simonovic P, Simic V, Gacic Z, Diamantini E, Stella E, Petrovic M, Majone B, Bellin A, Paunovic M, Vukovic-Gacic B |
Sci Total Environ |
10.1016/j.scitotenv.2016.07.099 |
2016 |
* |
Pathogenicity |
Assessment of the mutagenic and genotoxic activity of cyanobacterial toxin beta-N-methyl-amino-L-alanine in Salmonella typhimurium. |
Novak M, Hercog K, Zegura B |
Toxicon |
10.1016/j.toxicon.2016.04.047 |
2016 |
* |
Pathogenicity |
Comparative cytotoxic and genotoxic potential of 13 drinking water disinfection by-products using a microplate-based cytotoxicity assay and a developed SOS/umu assay. |
Zhang SH, Miao DY, Tan L, Liu AL, Lu WQ |
Mutagenesis |
10.1093/mutage/gev053 |
2015 |
* |
Pathogenicity |
Application of the SOS/umu test and high-content in vitro micronucleus test to determine genotoxicity and cytotoxicity of nine benzothiazoles. |
Ye Y, Weiwei J, Na L, Mei M, Kaifeng R, Zijian W |
J Appl Toxicol |
10.1002/jat.2972 |
2014 |
* |
Pathogenicity |
Facile synthesis of 4-O-beta-N-acetylchitooligosyl 2-acetamido-2,3-dideoxydidehydro-gluconolactone based on the transformation of chitooligosaccharide and its suppressive effects against the furylfuramide-induced SOS response. |
Ogata M, Takeuchi R, Suzuki A, Hirai H, Usui T |
Biosci Biotechnol Biochem |
10.1271/bbb.120119 |
2012 |
* |
Pathogenicity |
Contributions of flumequine and nitroarenes to the genotoxicity of river and ground waters. |
Ma F, Yuan G, Meng L, Oda Y, Hu J |
Chemosphere |
10.1016/j.chemosphere.2012.02.080 |
2012 |
* |
Pathogenicity |
Roles of human sulfotransferases in genotoxicity of carcinogens using genetically engineered umu test strains. |
Oda Y, Zhang Y, Buchinger S, Reifferscheid G, Yang M |
Environ Mol Mutagen |
10.1002/em.20696 |
2011 |
* |
Pathogenicity |
Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test. |
Sieroslawska A, Rymuszka A |
Neuro Endocrinol Lett |
NEL31S210A04 |
2010 |
* |
Metabolism |
Suppression of SOS-inducing activity of chemical mutagens by metabolites from microbial transformation of (+)-longicyclene. |
Sakata K, Miyazawa M |
J Agric Food Chem |
10.1021/jf101846p |
2010 |
* |
Enzymology |
Suppression of SOS-inducing activity of chemical mutagens by metabolites from microbial transformation of (-)-isolongifolene. |
Sakata K, Oda Y, Miyazawa M |
J Agric Food Chem |
10.1021/jf903651c |
2010 |
* |
Enzymology |
Genotoxic activation of the environmental pollutant 3,6-dinitrobenzo[e]pyrene in Salmonella typhimurium umu strains expressing human cytochrome P450 and N-acetyltransferase. |
Oda Y, Hirayama T, Watanabe T |
Toxicol Lett |
10.1016/j.toxlet.2009.04.010 |
2009 |
* |
Pathogenicity |
Combination of in vitro bioassays for the determination of cytotoxic and genotoxic potential of wastewater, surface water and drinking water samples. |
Zegura B, Heath E, Cernosa A, Filipic M |
Chemosphere |
10.1016/j.chemosphere.2009.02.041 |
2009 |
* |
Metabolism |
Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5. |
Li W, Dai Y, Xue B, Li Y, Peng X, Zhang J, Yan Y |
J Hazard Mater |
10.1016/j.jhazmat.2008.12.111 |
2008 |
* |
Enzymology |
Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays. |
Cao N, Yang M, Zhang Y, Hu J, Ike M, Hirotsuji J, Matsui H, Inoue D, Sei K |
Sci Total Environ |
10.1016/j.scitotenv.2008.10.048 |
2008 |
* |
Metabolism |
Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains. |
Oda Y, Watanabe T, Terao Y, Nukaya H, Wakabayashi K |
Mutat Res |
10.1016/j.mrgentox.2008.04.013 |
2008 |
* |
Pathogenicity |
Suppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test. |
Hisama M, Matsuda S, Tanaka T, Shibayama H, Nomura M, Iwaki M |
J Oleo Sci |
10.5650/jos.57.381 |
2008 |
* |
Pathogenicity |
Antimutagenic activity of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate. |
Hisama M, Matsuda S, Shibayama H, Iwaki M |
Yakugaku Zasshi |
10.1248/yakushi.128.933 |
2008 |
* |
Pathogenicity |
Suppressive components in rice husk against mutagens-induced SOS response using Salmonella typhimurium TA1535/pSK1002 umu test. |
Okuno Y, Miyazawa M |
Nat Prod Res |
10.1080/14786410701256358 |
2007 |
* |
Metabolism |
Reed beds receiving industrial sludge containing nitroaromatic compounds. Effects of outgoing water and bed material extracts in the umu-c genotoxicity assay, DR-CALUX assay and on early life stage development in zebrafish (Danio rerio). |
Gustavsson L, Hollert H, Jonsson S, van Bavel B, Engwall M |
Environ Sci Pollut Res Int |
10.1065/espr2006.11.360 |
2007 |
* |
Pathogenicity |
Genotoxic risk identification of soil contamination at a major industrialized city in northeast China by a combination of in vitro and in vivo bioassays. |
Xiao RY, Wang Z, Wang CX, Yu G, Zhu YG |
Environ Sci Technol |
10.1021/es0607335 |
2006 |
* |
Pathogenicity |
Ecotoxicological assessment of PAHs and their dead-end metabolites after degradation by Mycobacterium sp. strain SNP11. |
Pagnout C, Rast C, Veber AM, Poupin P, Ferard JF |
Ecotoxicol Environ Saf |
10.1016/j.ecoenv.2006.03.005 |
2006 |
* |
Phylogeny |
Different results of the Salmonella umu test between three isomers of phenylenediamine (PDA) derivatives. |
Yasunaga K, Kiyonari A, Nakagawa M, Yoshikawa K |
Drug Chem Toxicol |
10.1080/01480540600566766 |
2006 |
* |
Pathogenicity |
Antioxidant effects of hydroxybenzalacetones on peroxynitrite-induced lipid peroxidation in red blood cell membrane ghost and SOS response in Salmonella typhimurium TA4107/pSK1002. |
Motohashi N, Takahashi A, Yamagami C, Saito Y |
Chem Pharm Bull (Tokyo) |
10.1248/cpb.53.1003 |
2005 |
* |
Enzymology |
Electrochemical mutagen screening using microbial chip. |
Matsui N, Kaya T, Nagamine K, Yasukawa T, Shiku H, Matsue T |
Biosens Bioelectron |
10.1016/j.bios.2005.05.004 |
2005 |
* |
Pathogenicity |
Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test. |
Miyazawa M, Okuno Y, Imanishi K |
J Agric Food Chem |
10.1021/jf035430y |
2005 |
* |
Pathogenicity |
Suppression of chemical mutagen-induced SOS response by allylbenzen from Asiasarum heterotropoides in the Salmonella typhimurium TA1535/PSK1002 umu test. |
Miyazawa M, Kohno G |
Nat Prod Res |
10.1080/14786410310001643858 |
2005 |
* |
Pathogenicity |
Effects of diet composition on mutagenic activity in urine. |
Ohara A, Matsuhisa T |
Biofactors |
10.1002/biof.5520220122 |
2004 |
* |
Metabolism |
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone. |
Okuno Y, Miyazawa M |
J Nat Prod |
10.1021/np034007g |
2004 |
* |
Pathogenicity |
Potent antioxidative and antigenotoxic activity in aqueous extract of Japanese rice bran--association with peroxidase activity. |
Higashi-Okai K, Kanbara K, Amano K, Hagiwara A, Sugita C, Matsumoto N, Okai Y |
Phytother Res |
10.1002/ptr.1576 |
2004 |
* |
Pathogenicity |
Evaluation of the Salmonella umu test with 83 NTP chemicals. |
Yasunaga K, Kiyonari A, Oikawa T, Abe N, Yoshikawa K |
Environ Mol Mutagen |
10.1002/em.20053 |
2004 |
* |
Pathogenicity |
Inhibitory effects of water-soluble cationic manganese porphyrins on peroxynitrite-induced SOS response in Salmonella typhimurium TA4107/pSK1002. |
Motohashi N, Takahashi A, Mifune M, Saito Y |
Mutat Res |
10.1016/j.mrfmmm.2004.04.010 |
2004 |
* |
Pathogenicity |
Use of a high-throughput umu-microplate test system for rapid detection of genotoxicity produced by mutagenic carcinogens and airborne particulate matter. |
Oda Y, Funasaka K, Kitano M, Nakama A, Yoshikura T |
Environ Mol Mutagen |
10.1002/em.10209 |
2004 |
* |
Pathogenicity |
Antimutagenic activity of flavonoids from Chrysanthemum morifolium. |
Miyazawa M, Hisama M |
Biosci Biotechnol Biochem |
10.1271/bbb.67.2091 |
2003 |
* |
Metabolism |
Genotoxic activities of drug-nitrite interaction products. |
Ozhan G, Alpertunga B |
Drug Chem Toxicol |
10.1081/dct-120024844 |
2003 |
* |
Enzymology |
Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum). |
Miyazawa M, Hisama M |
J Agric Food Chem |
10.1021/jf030247q |
2003 |
* |
Enzymology |
Suppressive effect of the SOS-inducing activity of chemical mutagen by citric acid esters from Prunus mume Sieb. Et Zucc. using the Salmonella typhimurium TA1535/pSK1002 umu test. |
Miyazawa M, Yamada T, Utsunomiya H |
Nat Prod Res |
10.1080/1057563031000072550 |
2003 |
* |
Metabolism |
Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds. |
Feng Q, Kumagai T, Nakamura Y, Uchida K, Osawa T |
Mutat Res |
10.1016/s1383-5718(03)00057-3 |
2003 |
* |
Pathogenicity |
Effect of sample preparation on the in vitro genotoxicity of a light curable glass ionomer cement. |
Muller BP, Eisentrager A, Jahnen-Dechent W, Dott W, Hollender J |
Biomaterials |
10.1016/s0142-9612(02)00375-7 |
2003 |
* |
Enzymology |
Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay. |
Takemoto K, Yamazaki H, Nakajima M, Yokoi T |
Mutat Res |
10.1016/s1383-5718(02)00141-9 |
2002 |
* |
Cultivation |
Screening of Basidiomycete mushroom extracts for antigenotoxic and bio-antimutagenic activity. |
Filipic M, Umek A, Mlinaric A |
Pharmazie |
|
2002 |
* |
Enzymology |
Induction of SOS response in Salmonella typhimurium TA4107/pSK1002 by peroxynitrite-generating agent, N-morpholino sydnonimine. |
Motohashi N, Saito Y |
Mutat Res |
10.1016/s0027-5107(02)00025-8 |
2002 |
* |
Pathogenicity |
The cytotoxic and genotoxic potential of surface water and wastewater effluents as determined by bioluminescence, umu-assays and selected biomarkers. |
Dizer H, Wittekindt E, Fischer B, Hansen PD |
Chemosphere |
10.1016/s0045-6535(01)00062-5 |
2002 |
* |
Enzymology |
Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. |
Ueng YF, Shyu CC, Liu TY, Oda Y, Lin YL, Liao JF, Chen CF |
Biochem Pharmacol |
10.1016/s0006-2952(01)00816-4 |
2001 |
* |
Pathogenicity |
Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust. |
Hatanaka N, Yamazaki H, Kizu R, Hayakawa K, Aoki Y, Iwanari M, Nakajima M, Yokoi T |
Carcinogenesis |
10.1093/carcin/22.12.2033 |
2001 |
* |
Metabolism |
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay. |
Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T |
Mutat Res |
10.1016/s1383-5718(01)00254-6 |
2001 |
* |
Enzymology |
Antimutagenic activity of isoflavone from Pueraria lobata. |
Miyazawa M, Sakano K, Nakamura S, Kosaka H |
J Agric Food Chem |
10.1021/jf000255w |
2001 |
* |
Pathogenicity |
Enhancing effect of a plastic plasticizer, di-2-ethylhexyl phthalate on umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). |
Okai Y, Higashi-Okai K |
J UOEH |
10.7888/juoeh.22.305 |
2000 |
* |
Metabolism |
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. |
Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T |
Mutat Res |
10.1016/s1383-5718(00)00138-8 |
2000 |
* |
Pathogenicity |
Suppression of the furylfuramide-induced SOS response by monoterpenoids with a p-menthane skeleton using the Salmonella typhimurium TA1535/pSK1002 Umu test. |
Miyazawa M, Okuno Y, Nakamura Si, Kosaka H |
J Agric Food Chem |
10.1021/jf0002544 |
2000 |
* |
Pathogenicity |
The application of reporter gene assays for the determination of the toxic potency of diffuse air pollution. |
Hamers T, van Schaardenburg, Felzel EC, Murk AJ, Koeman JH |
Sci Total Environ |
10.1016/s0048-9697(00)00600-8 |
2000 |
* |
Pathogenicity |
Assessment of the water-extractable genotoxic potential of soil samples from contaminated sites. |
Ehrlichmann H, Dott W, Eisentraeger A |
Ecotoxicol Environ Saf |
10.1006/eesa.1999.1875 |
2000 |
* |
Pathogenicity |
Antimutagenic activity of flavonoids from Pogostemon cablin. |
Miyazawa M, Okuno Y, Nakamura S, Kosaka H |
J Agric Food Chem |
10.1021/jf990160y |
2000 |
* |
Enzymology |
In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver. |
Ueng YF, Chang YL, Oda Y, Park SS, Liao JF, Lin MF, Chen CF |
Life Sci |
10.1016/s0024-3205(99)00528-7 |
1999 |
* |
Pathogenicity |
Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium. |
Miyazawa M, Okuno Y, Fukuyama M, Nakamura S, Kosaka H |
J Agric Food Chem |
10.1021/jf990176o |
1999 |
* |
Enzymology |
Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. |
Miyazawa M, Shimamura H, Nakamura S, Sugiura W, Kosaka H, Kameoka H |
J Agric Food Chem |
10.1021/jf970930a |
1999 |
* |
Enzymology |
Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002. |
Oda Y, Yamazaki H, Shimada T |
Carcinogenesis |
10.1093/carcin/20.6.1079 |
1999 |
* |
Pathogenicity |
Studies on the genotoxicity of endosulfan in bacterial systems. |
Chaudhuri K, Selvaraj S, Pal AK |
Mutat Res |
10.1016/s1383-5718(98)00174-0 |
1999 |
* |
Pathogenicity |
Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test. |
Miyazawa M, Okuno Y, Oshiro K, Kasahara H, Shimamura H, Nakamura S, Kameoka H |
Biosci Biotechnol Biochem |
|
1998 |
* |
Pathogenicity |
Correlation between on-line PAH detection in airborne particle samples and their bacterial genotoxicity. |
Wasserkort R, Hartmann A, Widmer RM, Burtscher H |
Ecotoxicol Environ Saf |
10.1006/eesa.1998.1653 |
1998 |
* |
Pathogenicity |
Potent suppressing activity of the non-polyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002)--association with pheophytins a and b. |
Okai Y, Higashi-Okai K |
Cancer Lett |
10.1016/s0304-3835(97)00294-2 |
1997 |
* |
Enzymology |
Increase of sensitivity and validity of the SOS/umu-test after replacement of the beta-galactosidase reporter gene with luciferase. |
Schmid C, Reifferscheid G, Zahn RK, Bachmann M |
Mutat Res |
10.1016/s1383-5718(97)00118-6 |
1997 |
* |
Pathogenicity |
Antimutagenic effect of resveratrol against Trp-P-1. |
Uenobe F, Nakamura S, Miyazawa M |
Mutat Res |
10.1016/s0027-5107(96)00191-1 |
1997 |
* |
Pathogenicity |
Potent suppressive activity of nonpolyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002), tumor promotor-dependent ornithine decarboxylase induction of BALB/c 3T3 fibroblast cells, and chemically induced mouse skin tumorigenesis. |
Okai Y, Higashi-Okai K |
Teratog Carcinog Mutagen |
10.1002/(SICI)1520-6866(1997)17:6<305::AID-TCM1>3.0.CO;2-L |
1997 |
* |
Metabolism |
Induction of cell killing, mutation and umu gene expression by 6-mercaptopurine or 2-thiouracil with UVA irradiation. |
Komeda K, Iwamoto S, Kominami S, Ohnishi T |
Photochem Photobiol |
10.1111/j.1751-1097.1997.tb01885.x |
1997 |
* |
Enzymology |
Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. |
Matsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, Sawada M, Hayashi M, Nohmi T, Yoshihira K, Ishidate M Jr, Sofuni T |
Mutagenesis |
10.1093/mutage/11.6.573 |
1996 |
* |
Pathogenicity |
Suppressive effects of chlorophyllin on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. |
Okai Y, Higashi-Okai K, Yano Y, Otani S |
Mutat Res |
10.1016/s0165-1218(96)90122-6 |
1996 |
* |
Enzymology |
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. |
Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, Sutter TR |
Cancer Res |
|
1996 |
* |
Pathogenicity |
Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). |
Okai Y, Higashi-Okai K, Nakamura S, Yano Y, Otani S |
Mutat Res |
10.1016/0165-1218(95)00109-3 |
1996 |
* |
Metabolism |
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs. |
Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng YF, Guengerich FP, Inui Y |
Drug Metab Dispos |
|
1996 |
* |
Metabolism |
A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system. |
Oda Y, Yamazaki H, Thier R, Ketterer B, Guengerich FP, Shimada T |
Carcinogenesis |
10.1093/carcin/17.2.297 |
1996 |
* |
Pathogenicity |
All-trans beta-carotene enhances mitogenic responses and ornithine decarboxylase activity of BALB/c 3T3 fibroblast cells induced by tumor promoter and fetal bovine serum but suppresses mutagen-dependent umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). |
Okai Y, Higashi-Okai K, Yano Y, Otani S |
Cancer Lett |
10.1016/0304-3835(95)04032-3 |
1996 |
* |
Enzymology |
Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. |
Shimada T, Yamazaki H, Oda Y, Hiratsuka A, Watabe T, Guengerich FP |
Chem Res Toxicol |
10.1021/tx950125v |
1996 |
* |
Pathogenicity |
Inhibitory effect of curcumin on SOS functions induced by UV irradiation. |
Oda Y |
Mutat Res |
10.1016/0165-7992(95)00048-8 |
1995 |
* |
Enzymology |
Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes. |
Yamazaki H, Inui Y, Wrighton SA, Guengerich FP, Shimada T |
Carcinogenesis |
10.1093/carcin/16.9.2167 |
1995 |
* |
Enzymology |
On the induction of protective responses in Salmonella typhimurium strain TA1535/pSK1002 by UVA (365 nm). |
Rahman S, Bose B, Chatterjee SN |
Photochem Photobiol |
10.1111/j.1751-1097.1995.tb02347.x |
1995 |
* |
Enzymology |
Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity. |
Oda Y, Yamazaki H, Watanabe M, Nohmi T, Shimada T |
Mutat Res |
10.1016/0165-1161(95)90005-5 |
1995 |
* |
Enzymology |
Suppressive effects of the extracts of Japanese edible seaweeds on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promotor-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. |
Okai Y, Higashi-Okai K, Nakamura S, Yano Y, Otani S |
Cancer Lett |
10.1016/0304-3835(94)90405-7 |
1994 |
* |
Enzymology |
Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. |
Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP |
Carcinogenesis |
10.1093/carcin/15.11.2523 |
1994 |
* |
Pathogenicity |
[The SOS-inhibition activity of human urine investigated by umu-test--diurnal and daily changes of SOS-inhibition activity of urine]. |
Yamamoto N, Sugiura W, Kosaka H, Nakamura S |
Nihon Eiseigaku Zasshi |
10.1265/jjh.49.791 |
1994 |
* |
Pathogenicity |
Suppressive effects of urine on the SOS responses induced by UV and chemical mutagens. |
Ikemoto S, Kamizuru M, Hayahara N, Wada S, Kishimoto T |
Cancer Lett |
10.1016/0304-3835(94)90156-2 |
1994 |
* |
Metabolism |
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. |
Yamazaki H, Mimura M, Oda Y, Gonzalez FJ, el-Bayoumy K, Chae YH, Guengerich FP, Shimada T |
Carcinogenesis |
10.1093/carcin/15.3.465 |
1994 |
* |
Pathogenicity |
Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by the umu gene expression system in Salmonella typhimurium (TA1535/pSK1002). |
Okai Y, Higashi-Okai K, Nakamura S |
Mutat Res |
10.1016/0165-7992(93)90096-e |
1993 |
* |
Enzymology |
Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. |
Yamazaki H, Mimura M, Oda Y, Inui Y, Shiraga T, Iwasaki K, Guengerich FP, Shimada T |
Carcinogenesis |
10.1093/carcin/14.7.1271 |
1993 |
* |
Enzymology |
Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O-acetyltransferase and nitroreductase activities. |
Oda Y, Yamazaki H, Watanabe M, Nohmi T, Shimada T |
Environ Mol Mutagen |
10.1002/em.2850210407 |
1993 |
* |
Enzymology |
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. |
Shimada T, Yamazaki H, Mimura M, Guengerich FP |
Mutat Res |
10.1016/0027-5107(92)90007-o |
1992 |
* |
Pathogenicity |
The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response. |
Benamira M, Marnett LJ |
Mutat Res |
10.1016/0921-8777(92)90002-k |
1992 |
* |
Enzymology |
A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM1011 having a high nitroreductase activity. |
Oda Y, Shimada T, Watanabe M, Ishidate M Jr, Nohmi T |
Mutat Res |
10.1016/0165-1161(92)90037-m |
1992 |
* |
Enzymology |
Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes. |
Yamazaki H, Oda Y, Shimada T |
Mutat Res |
10.1016/0165-1161(92)90046-o |
1992 |
* |
Enzymology |
Mutagenic activation of aflatoxin B1 by pulmonary, renal, and hepatic cytochrome P450s from rats. |
Imaoka S, Ikemoto S, Shimada T, Funae Y |
Mutat Res |
10.1016/0027-5107(92)90204-f |
1992 |
* |
Metabolism |
Activation of 6-aminochrysene to genotoxic products by different forms of rat liver cytochrome P450 in an O-acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). |
Yamazaki H, Shimada T |
Biochem Pharmacol |
10.1016/0006-2952(92)90123-z |
1992 |
* |
Pathogenicity |
On the induction of umu gene expression in Salmonella typhimurium strain TA1535/pSK1002 by some nitrofurans. |
Pal AK, Rahman MS, Chatterjee SN |
Mutat Res |
10.1016/0165-1218(92)90019-v |
1992 |
* |
Pathogenicity |
A microplate version of the SOS/umu-test for rapid detection of genotoxins and genotoxic potentials of environmental samples. |
Reifferscheid G, Heil J, Oda Y, Zahn RK |
Mutat Res |
10.1016/0165-1161(91)90134-t |
1991 |
* |
Enzymology |
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. |
Shimada T, Guengerich FP |
Cancer Res |
|
1991 |
* |
Pathogenicity |
Plasmid pSK1002-mediated mutator effect and SOS response and SOS mutagenesis of 2,5-dichloronitrobenzol in Salmonella typhimurium. |
Jin ZC, Qian J |
Mutat Res |
10.1016/0165-7992(91)90038-6 |
1991 |
* |
Pathogenicity |
[Plasmid pSK1002-mediated mutator effect and SOS response in Salmonella typhimurium and its use for detection of mutagens]. |
Jin ZC, Qian J |
Zhonghua Yu Fang Yi Xue Za Zhi |
|
1991 |
* |
Metabolism |
Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes. |
Yamazaki H, Degawa M, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada T |
Carcinogenesis |
10.1093/carcin/12.1.133 |
1991 |
* |
Enzymology |
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. |
Brian WR, Sari MA, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FP |
Biochemistry |
10.1021/bi00503a018 |
1990 |
* |
Pathogenicity |
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. |
Guengerich FP, Kim DH |
Carcinogenesis |
10.1093/carcin/11.12.2275 |
1990 |
* |
Metabolism |
Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. |
Shimada T, Guengerich FP |
Cancer Res |
|
1990 |
* |
Pathogenicity |
[Genotoxicity of synthetic dyes in umu test using Salmonella typhimurium TA1535/pSK1002 (1). Results of examination for acid dyes, direct dyes, disperse dyes and reactive dyes]. |
Kosaka H, Nakamura S |
Sangyo Igaku |
10.1539/joh1959.32.89 |
1990 |
* |
Pathogenicity |
Induction of umu gene expression in Salmonella typhimurium TA1535/pSK1002 by dimethyl sulfoxide (DMSO). |
Nakamura S, Oda Y, Ugawa M |
Mutat Res |
10.1016/0027-5107(90)90003-m |
1990 |
* |
Metabolism |
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes. |
Shimada T, Yamazaki H, Shimura H, Tanaka R, Guengerich FP |
Carcinogenesis |
10.1093/carcin/11.1.103 |
1990 |
* |
Enzymology |
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. |
Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP |
Cancer Res |
|
1989 |
* |
Pathogenicity |
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. |
Shimada T, Iwasaki M, Martin MV, Guengerich FP |
Cancer Res |
|
1989 |
* |
Metabolism |
Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. |
Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FP |
Chem Res Toxicol |
10.1021/tx00008a008 |
1989 |
* |
Metabolism |
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. |
Shimada T, Guengerich FP |
Proc Natl Acad Sci U S A |
10.1073/pnas.86.2.462 |
1989 |
* |
Metabolism |
Metabolic activation of environmental carcinogens and mutagens by human liver microsomes. Role of cytochrome P-450 homologous to a 3-methylcholanthrene-inducible isozyme in rat liver. |
Shimada T, Okuda Y |
Biochem Pharmacol |
10.1016/0006-2952(88)90215-8 |
1988 |
* |
Enzymology |
SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. |
Nakamura SI, Oda Y, Shimada T, Oki I, Sugimoto K |
Mutat Res |
10.1016/0165-7992(87)90063-7 |
1987 |
* |
Metabolism |
Genotoxic and mutagenic activation of aflatoxin B1 by constitutive forms of cytochrome P-450 in rat liver microsomes. |
Shimada T, Nakamura S, Imaoka S, Funae Y |
Toxicol Appl Pharmacol |
10.1016/0041-008x(87)90189-x |
1987 |
* |
Metabolism |
Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002. |
Shimada T, Nakamura S |
Biochem Pharmacol |
10.1016/0006-2952(87)90497-7 |
1987 |
* |
Enzymology |
Application of SOS umu-test for the detection of genotoxic volatile chemicals and air pollutants. |
Ong TM, Stewart J, Wen YF, Whong WZ |
Environ Mutagen |
10.1002/em.2860090207 |
1987 |
* |
Pathogenicity |
Suppressive effects of coffee on the SOS responses induced by UV and chemical mutagens. |
Obana H, Nakamura S, Tanaka R |
Mutat Res |
10.1016/0165-7992(86)90124-7 |
1986 |
* |
Enzymology |
Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. |
Oda Y, Nakamura S, Oki I, Kato T, Shinagawa H |
Mutat Res |
10.1016/0165-1161(85)90062-7 |
1985 |
* |
|
A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species. |
Oalde Pavlovic M, Kolarevic S, Dordevic J, Jovanovic Maric J, Lunic T, Mandic M, Kracun Kolarevic M, Zivkovic J, Alimpic Aradski A, Marin PD, Savikin K, Vukovic-Gacic B, Bozic Nedeljkovic B, Duletic-Lausevic S |
Plants (Basel) |
10.3390/plants10112306 |
2021 |
* |
|
Development and progress for three decades in umu test systems. |
Oda Y |
Genes Environ |
10.1186/s41021-016-0054-8 |
2016 |
* |
|
Evaluation of Protective Effects of Bioactive Phytochemicals Against Methotrexate in Salmonella typhimurium TA1535/pSK1002 Coupled with Micronucleus Assay. |
Wu Y, Gu SB, Li H, He JY, Li L, Yang JB |
Biomed Environ Sci |
10.3967/bes2016.017 |
2016 |
* |
|
Antimutagenic and Anticarcinogenic Effect of Methanol Extracts of Sweetpotato (Ipomea batata) Leaves. |
Kang HG, Jeong SH, Cho JH |
Toxicol Res |
10.5487/TR.2010.26.1.029 |
2010 |
* |
|
Suppression of chemical mutagen-induced SOS response by alkylphenols from clove (Syzygium aromaticum) in the Salmonella typhimurium TA1535/pSK1002 umu test. |
Miyazawa M, Hisama M |
J Agric Food Chem |
10.1021/jf0103469 |
2001 |
* |
|
Suppression of furylfuramide-induced SOS response by acetophenones using Salmonella typhimurium TA1535/pSK1002 umu test. |
Miyazawa M, Shimamura H, Nakamura Si, Sugiura W |
J Agric Food Chem |
10.1021/jf990631g |
2000 |
* |
|
Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test. |
Miyazawa M, Okuno Y, Oshiro K, Kasahara H, Shimamura H, Nakamura S, Kameoka H |
Biosci Biotechnol Biochem |
10.1271/bbb.62.1425 |
1998 |
* |
|
The genotoxicity of diaveridine and trimethoprim. |
Ono T, Sekiya T, Takahashi Y, Sasaki YF, Izumiyama F, Nishidate E, Tsuda S, Ohta T |
Environ Toxicol Pharmacol |
10.1016/s1382-6689(97)00026-4 |
1997 |
* |
|
Identification of antimutagenic substances in an extract of edible red alga, Porphyra tenera (Asakusa-nori) |
Okai Y, Higashi-Okai K, Yano Y, Otani S |
Cancer Lett |
10.1016/0304-3835(95)04101-x |
1996 |
* |
|
Assessment of the mutagenicity of extracts of TMV-coat-protein-gene induced transgenic tomato by the umu-test. |
Shinmoto H, Tomizawa A, Kobori M, Tsushida T, Shinohara K |
Biosci Biotechnol Biochem |
10.1271/bbb.59.2151 |
1995 |
* |
|
[Genotoxicity of synthetic dyes in the umu test using Salmonella typhimurium TA1535/pSK1002 (II). Results of examination of basic dyes]. |
Nakamura S, Kosaka H, Kawakami M, Matsuoka Y, Matsuoka H, Morimoto K |
Sangyo Igaku |
|
1990 |
* |