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Strain identifier

BacDive ID: 5109

Type strain: No

Species: Salmonella enterica subsp. enterica

Strain Designation: pSK1002, TA 1535/pSK 1002

NCBI tax ID(s): 59201 (subspecies)

For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 3530

BacDive-ID: 5109

DSM-Number: 9274

keywords: Bacteria

description: Salmonella enterica subsp. enterica pSK1002 is a bacterium of the family Enterobacteriaceae.

NCBI tax id

  • NCBI tax id: 59201
  • Matching level: subspecies

doi: 10.13145/bacdive5109.20221219.7.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/pseudomonadota
  • domain: Bacteria
  • phylum: Pseudomonadota
  • class: Gammaproteobacteria
  • order: Enterobacterales
  • family: Enterobacteriaceae
  • genus: Salmonella
  • species: Salmonella enterica subsp. enterica
  • full scientific name: Salmonella enterica subsp. enterica (ex Kauffmann and Edwards 1952) Le Minor and Popoff 1987
  • synonyms

    • @ref: 20215
    • synonym: Salmonella choleraesuis subsp. choleraesuis

@ref: 3530

domain: Bacteria

phylum: Proteobacteria

class: Gammaproteobacteria

order: Enterobacteriales, not validated

family: Enterobacteriaceae

genus: Salmonella

species: Salmonella enterica subsp. enterica

full scientific name: Salmonella enterica subsp. enterica (ex Kauffmann and Edwards 1952) Le Minor and Popoff 1987

strain designation: pSK1002, TA 1535/pSK 1002

type strain: no

Physiology and metabolism

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6836830849L-arabinose+fermentation
6836827613amygdalin-fermentation
6836828053melibiose+fermentation
6836817992sucrose-fermentation
6836862345L-rhamnose+fermentation
6836830911sorbitol+fermentation
6836817268myo-inositol+fermentation
6836816899D-mannitol+fermentation
6836817634D-glucose+fermentation
683685291gelatin-hydrolysis
6836827897tryptophan-energy source
6836816199urea-hydrolysis
6836818257ornithine+degradation
6836825094lysine+degradation
6836829016arginine+hydrolysis

metabolite production

@refChebi-IDmetaboliteproduction
6836815688acetoinno
6836835581indoleno
6836816136hydrogen sulfideno

metabolite tests

@refChebi-IDmetabolitevoges-proskauer-testindole test
6836815688acetoin-
6836835581indole-

enzymes

@refvalueactivityec
68368cytochrome oxidase-1.9.3.1
68368gelatinase-
68368tryptophan deaminase-4.1.99.1
68368urease-3.5.1.5
68368ornithine decarboxylase+4.1.1.17
68368lysine decarboxylase+4.1.1.18
68368arginine dihydrolase+3.5.3.6

API 20E

@refONPGADH ArgLDC LysODCCITH2SURETDA TrpINDVPGELGLUMANINOSorRHASACMELAMYARAOX
3530+++++------+++++-+-+-
3530-+++-------+++++-+-+-
3530++++-------+++++-+-+-
3530+++++------+++++-+-+-

Safety information

risk assessment

  • @ref: 3530
  • biosafety level: 1
  • biosafety level comment: Risk group (German classification)

External links

@ref: 3530

culture collection no.: DSM 9274

straininfo link

  • @ref: 20218
  • passport: http://www.straininfo.net/strains/340024

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Enzymology1281274Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens.Shimada T, Yamazaki H, Mimura M, Guengerich FPMutat Res10.1016/0027-5107(92)90007-o1992Aflatoxins/pharmacology, Animals, Benzoflavones/pharmacology, Biotransformation, Carcinogenicity Tests, Carcinogens/*metabolism, Cytochrome P-450 Enzyme System/drug effects/*physiology, DNA/*drug effects, DNA Damage, In Vitro Techniques, Lung/*enzymology, Male, Microsomes/*enzymology, Microsomes, Liver/enzymology, Phenobarbital/pharmacology, Pregnenolone/pharmacology, Rats, Rats, Sprague-Dawley, SOS Response, Genetics, Safrole/pharmacology, Sterigmatocystin/pharmacology, beta-NaphthoflavonePathogenicity
Pathogenicity1377346On the induction of umu gene expression in Salmonella typhimurium strain TA1535/pSK1002 by some nitrofurans.Pal AK, Rahman MS, Chatterjee SNMutat Res10.1016/0165-1218(92)90019-v1992Azides/toxicity, Gene Expression Regulation, Bacterial/*drug effects, Genes, Bacterial, Methylnitronitrosoguanidine/toxicity, Mutagens/*toxicity, Nitrofurans/*toxicity, Salmonella typhimurium/*genetics, Sodium Azide, beta-Galactosidase/metabolismMetabolism
Enzymology1383706Mutagenic activation of aflatoxin B1 by pulmonary, renal, and hepatic cytochrome P450s from rats.Imaoka S, Ikemoto S, Shimada T, Funae YMutat Res10.1016/0027-5107(92)90204-f1992Aflatoxin B1/*metabolism/*pharmacology, Animals, Biotransformation, Cytochrome P-450 Enzyme System/immunology/*metabolism, DNA Damage, Gene Expression/drug effects, Immunoglobulin G/pharmacology, Isoenzymes/immunology/*metabolism, Kidney/*enzymology, Lung/*enzymology, Microsomes/*enzymology, Microsomes, Liver/*enzymology, Mutagenicity Tests, Rats, Rats, Sprague-Dawley, Salmonella typhimurium/drug effects/geneticsMetabolism
Enzymology1383750Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes.Yamazaki H, Oda Y, Shimada TMutat Res10.1016/0165-1161(92)90046-o1992Amines/pharmacokinetics/*toxicity, Animals, Biotransformation, Carcinogens/pharmacokinetics/*toxicity, Cytochrome P-450 Enzyme System/*metabolism, Kinetics, Male, Microsomes, Liver/*enzymology, Mutagenicity Tests/*methods, Rats, Rats, Sprague-Dawley, Salmonella typhimurium/*drug effects/genetics, Species SpecificityPhylogeny
Enzymology1383753A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM1011 having a high nitroreductase activity.Oda Y, Shimada T, Watanabe M, Ishidate M Jr, Nohmi TMutat Res10.1016/0165-1161(92)90037-m1992Cloning, Molecular, Deoxyribonuclease BamHI/metabolism, Genes, Bacterial, *Mutagenicity Tests, Nitro Compounds/*toxicity, Nitroreductases/genetics/*metabolism, SOS Response, Genetics/genetics, Salmonella typhimurium/*drug effects/enzymology/genetics, Sensitivity and SpecificityMetabolism
Pathogenicity1383804The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response.Benamira M, Marnett LJMutat Res10.1016/0921-8777(92)90002-k1992Acrolein/pharmacology, Aldehydes/pharmacology/*toxicity, *Lipid Peroxidation, Malondialdehyde/pharmacology, Mutagens/*toxicity, Operon, *SOS Response, Genetics, Salmonella typhimurium/drug effects
Metabolism1530660Activation of 6-aminochrysene to genotoxic products by different forms of rat liver cytochrome P450 in an O-acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).Yamazaki H, Shimada TBiochem Pharmacol10.1016/0006-2952(92)90123-z1992Acetyltransferases/antagonists & inhibitors/genetics, Animals, Benzoflavones, Biotransformation, Chrysenes/*metabolism/toxicity, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System/*metabolism, Dexamethasone, Dose-Response Relationship, Drug, Gene Expression/drug effects, Male, Microsomes, Liver/*enzymology, Mutagenicity Tests, Pentachlorophenol/pharmacology, Phenobarbital, Rats, Rats, Inbred Strains, Salmonella typhimurium/*drug effects/genetics, beta-NaphthoflavonePathogenicity
Pathogenicity1720196A microplate version of the SOS/umu-test for rapid detection of genotoxins and genotoxic potentials of environmental samples.Reifferscheid G, Heil J, Oda Y, Zahn RKMutat Res10.1016/0165-1161(91)90134-t1991Azides/toxicity, Environmental Monitoring/*methods, Gene Expression Regulation, Bacterial/drug effects, Hydrogen-Ion Concentration, Microsomes, Liver/metabolism, Mutagenesis, Mutagenicity Tests/*methods, Mutagens/*toxicity, SOS Response, Genetics/drug effects/genetics, Salmonella typhimurium/drug effects, Sodium Azide, Water Pollutants, Chemical/*toxicity, beta-Galactosidase/genetics/metabolismMetabolism
Pathogenicity1773674[Plasmid pSK1002-mediated mutator effect and SOS response in Salmonella typhimurium and its use for detection of mutagens].Jin ZC, Qian JZhonghua Yu Fang Yi Xue Za Zhi1991Humans, *Mutagenicity Tests, Mutagens/toxicity, Nitrobenzenes/toxicity, *Plasmids, *SOS Response, Genetics, Salmonella typhimurium/*genetics
Pathogenicity1881412Plasmid pSK1002-mediated mutator effect and SOS response and SOS mutagenesis of 2,5-dichloronitrobenzol in Salmonella typhimurium.Jin ZC, Qian JMutat Res10.1016/0165-7992(91)90038-61991Mutagenesis, Mutagenicity Tests, *Mutagens, Nitrobenzenes/*toxicity, *Plasmids, *SOS Response, Genetics, Salmonella typhimurium/drug effects/*genetics
Enzymology1913651Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.Shimada T, Guengerich FPCancer Res1991Aflatoxin B1/pharmacology, Animals, Aroclors/pharmacology, Benzoflavones/pharmacology, Carbolines/*metabolism, Chlorodiphenyl (54% Chlorine), Cytochrome P-450 Enzyme System/*physiology, DNA/*drug effects, Dose-Response Relationship, Drug, Humans, Imidazoles/*toxicity, In Vitro Techniques, Male, Microsomes, Liver/*enzymology, Mutagens/*toxicity, *Plants, Toxic, Quinidine/pharmacology, Rats, Rats, Inbred Strains, SOS Response, Genetics, Safrole/pharmacology, Smoke/*adverse effects, *Tobacco, beta-Galactosidase/biosynthesisPathogenicity
Metabolism1988174Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes.Yamazaki H, Degawa M, Funae Y, Imaoka S, Inui Y, Guengerich FP, Shimada TCarcinogenesis10.1093/carcin/12.1.1331991Animals, Benzoflavones/pharmacology, Biotransformation, Carcinogens/*metabolism, Cytochrome P-450 Enzyme System/*physiology, Enzyme Induction, Humans, Lipids/pharmacology, Male, Metyrapone/pharmacology, Microsomes, Liver/*metabolism, Pyridines/pharmacology, Rats, p-Aminoazobenzene/*analogs & derivatives/metabolismEnzymology
Pathogenicity2107398Induction of umu gene expression in Salmonella typhimurium TA1535/pSK1002 by dimethyl sulfoxide (DMSO).Nakamura S, Oda Y, Ugawa MMutat Res10.1016/0027-5107(90)90003-m1990Cloning, Molecular, Dimethyl Sulfoxide/*toxicity, Gene Expression/*drug effects, Genes, Bacterial/*drug effects, *Mutagens, SOS Response, Genetics/drug effects, Salmonella typhimurium/drug effects/genetics, Structure-Activity Relationship, beta-Galactosidase/geneticsEnzymology
Pathogenicity2117088[Genotoxicity of synthetic dyes in umu test using Salmonella typhimurium TA1535/pSK1002 (1). Results of examination for acid dyes, direct dyes, disperse dyes and reactive dyes].Kosaka H, Nakamura SSangyo Igaku10.1539/joh1959.32.891990Coloring Agents/*toxicity, Genes, Bacterial/*drug effects, Mutagenicity Tests, *Mutation, Salmonella typhimurium/*drug effects/enzymology/genetics, beta-Galactosidase/genetics/metabolismEnzymology
Metabolism2180560Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.Shimada T, Guengerich FPCancer Res1990Animals, Cytochrome P-450 CYP3A, *Cytochrome P-450 Enzyme System, Humans, Immunologic Techniques, In Vitro Techniques, Inactivation, Metabolic, Microsomes, Liver/*metabolism, Mixed Function Oxygenases/metabolism, Mutagens/*metabolism, Pyrenes/*metabolism, Rabbits, Rats, Substrate SpecificityEnzymology
Pathogenicity2265479In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.Guengerich FP, Kim DHCarcinogenesis10.1093/carcin/11.12.22751990Aflatoxins/*metabolism, Chamomile, Chromatography, High Pressure Liquid, Dihydropyridines/*metabolism, Felodipine/pharmacology, *Flavanones, Flavins/*pharmacology, Flavonoids/*pharmacology, Gene Expression Regulation, *Hesperidin, Humans, In Vitro Techniques, *Kaempferols, Microsomes, Liver/*drug effects/metabolism, Oils, Volatile/pharmacology, Plants, Medicinal, Quercetin/analogs & derivatives/pharmacology, Transcriptional ActivationMetabolism
Enzymology2271712Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.Brian WR, Sari MA, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FPBiochemistry10.1021/bi00503a0181990Alcohol Dehydrogenase/genetics, *Aryl Hydrocarbon Hydroxylases, Cloning, Molecular, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System/genetics/*metabolism, Cytochrome P450 Family 2, Gene Expression, Genetic Vectors, Humans, Kinetics, Liver/*enzymology, Microsomes/enzymology, Microsomes, Liver/enzymology, Plasmids, Promoter Regions, Genetic, Recombinant Fusion Proteins/isolation & purification/metabolism, Saccharomyces cerevisiae/*genetics, Spectrophotometry, Steroid 16-alpha-Hydroxylase, Substrate SpecificityMetabolism
2273583[Genotoxicity of synthetic dyes in the umu test using Salmonella typhimurium TA1535/pSK1002 (II). Results of examination of basic dyes].Nakamura S, Kosaka H, Kawakami M, Matsuoka Y, Matsuoka H, Morimoto KSangyo Igaku1990Coloring Agents/*toxicity, Mutagenicity Tests/*methods, Salmonella typhimurium/genetics
Metabolism2403855Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.Shimada T, Yamazaki H, Shimura H, Tanaka R, Guengerich FPCarcinogenesis10.1093/carcin/11.1.1031990Animals, Benzoflavones/pharmacology, Cytochrome P-450 Enzyme System/*metabolism, Furylfuramide/*metabolism/pharmacology, Humans, Inactivation, Metabolic, Kinetics, Methylcholanthrene/pharmacology, Microsomes, Liver/drug effects/*metabolism, Mutagenicity Tests, Neoplasms/metabolism, Nitrofurans/*metabolism, Phenobarbital/pharmacology, Rats, Reference Values, Salmonella typhimurium/drug effects, SpectrophotometryPathogenicity
Enzymology2434323Application of SOS umu-test for the detection of genotoxic volatile chemicals and air pollutants.Ong TM, Stewart J, Wen YF, Whong WZEnviron Mutagen10.1002/em.28600902071987Air Pollutants/*toxicity, Biotransformation, Cloning, Molecular, *DNA Damage, DNA, Bacterial/drug effects, Gases, Microsomes, Liver/metabolism, Mutagenicity Tests, *Mutagens, Plants, Toxic, SOS Response, Genetics, Salmonella typhimurium/drug effects, Smoke, Tobacco, Vehicle Emissions/toxicityPathogenicity
Metabolism2492107Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.Shimada T, Guengerich FPProc Natl Acad Sci U S A10.1073/pnas.86.2.4621989Aflatoxin B1, Aflatoxins/*metabolism, Antibodies/immunology, Benzoflavones/pharmacology, Biotransformation, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System/immunology/*metabolism, Humans, Immunochemistry, Microsomes, Liver/*enzymology, Mixed Function Oxygenases/immunology/*metabolism, Nifedipine/metabolism, Oxidation-Reduction, Sterigmatocystin/metabolism, Troleandomycin/pharmacologyPathogenicity
Enzymology2509067Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FPCancer Res19897,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*metabolism, Animals, Benzo(a)pyrene/*metabolism, Biotransformation, Cytochrome P-450 Enzyme System/genetics/*metabolism, DNA Damage, Dihydroxydihydrobenzopyrenes/*metabolism, Gene Expression, Genes/drug effects, Humans, Isoenzymes/genetics/*metabolism, Kinetics, Lung/*enzymology, Microsomes/*enzymology, Microsomes, Liver/*enzymology, Polycyclic Compounds/*metabolism, RatsMetabolism
Metabolism2519710Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses.Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FPChem Res Toxicol10.1021/tx00008a0081989Aflatoxin B1/metabolism/*toxicity, Aflatoxins/metabolism/*toxicity, DNA/chemistry, Enzyme Activation/drug effects, Epoxy Compounds/metabolism, Furans/metabolism, Guanine/chemistry, Humans, In Vitro Techniques, Liver/enzymology/metabolism, Magnetic Resonance Spectroscopy, Microsomes, Liver/enzymology, Mutagenicity Tests, *Mutagens, Oxidation-Reduction, Salmonella typhimurium/genetics, Sterigmatocystin/metabolism/*toxicityPathogenicity
Pathogenicity2655891Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.Shimada T, Iwasaki M, Martin MV, Guengerich FPCancer Res1989Animals, Biotransformation, Carcinogenicity Tests, Carcinogens/*metabolism/pharmacology, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System/*metabolism, Genes, Bacterial/*drug effects, Humans, Microsomes, Liver/*enzymology, Rats, Salmonella typhimurium/drug effects/*genetics, Structure-Activity RelationshipEnzymology
Pathogenicity3093858Suppressive effects of coffee on the SOS responses induced by UV and chemical mutagens.Obana H, Nakamura S, Tanaka RMutat Res10.1016/0165-7992(86)90124-719864-Nitroquinoline-1-oxide/antagonists & inhibitors, Caffeine/analysis, *Coffee/analysis, DNA Repair/*drug effects, Furylfuramide/antagonists & inhibitors, Methylnitronitrosoguanidine/antagonists & inhibitors, Mutagens/*antagonists & inhibitors, SOS Response, Genetics/*drug effects/radiation effects, Salmonella typhimurium/genetics, *Ultraviolet Rays
Metabolism3118508Genotoxic and mutagenic activation of aflatoxin B1 by constitutive forms of cytochrome P-450 in rat liver microsomes.Shimada T, Nakamura S, Imaoka S, Funae YToxicol Appl Pharmacol10.1016/0041-008x(87)90189-x1987Aflatoxin B1, Aflatoxins/*metabolism, Animals, Biotransformation, Cytochrome P-450 Enzyme System/*metabolism, DNA Damage, Female, Genes, Bacterial/*drug effects, Male, Microsomes, Liver/*enzymology, Mutagenicity Tests, Mutagens/*metabolism, Mutation, Oxygenases/metabolism, Rats, Rats, Inbred Strains, Salmonella typhimurium/genetics, Sex CharacteristicsPathogenicity
Metabolism3297069Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002.Shimada T, Nakamura SBiochem Pharmacol10.1016/0006-2952(87)90497-71987Animals, Carcinogens/*pharmacology, Cytochrome P-450 Enzyme System/*metabolism, DNA/*drug effects, Enzyme Activation, Furylfuramide/pharmacology, Gene Expression Regulation/*drug effects, Isoenzymes/metabolism, Male, Microsomes, Liver/enzymology, Mutagens/*pharmacology, Rats, Rats, Inbred Strains, Salmonella typhimurium/geneticsPathogenicity
Enzymology3317033SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals.Nakamura SI, Oda Y, Shimada T, Oki I, Sugimoto KMutat Res10.1016/0165-7992(87)90063-71987Biotransformation, *Carcinogens/pharmacokinetics, DNA Repair/*drug effects, Genes, Bacterial, Mutagenicity Tests, *Mutagens/pharmacokinetics, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*genetics, Structure-Activity RelationshipPathogenicity
Metabolism3337745Metabolic activation of environmental carcinogens and mutagens by human liver microsomes. Role of cytochrome P-450 homologous to a 3-methylcholanthrene-inducible isozyme in rat liver.Shimada T, Okuda YBiochem Pharmacol10.1016/0006-2952(88)90215-81988Adult, Animals, Biotransformation, Carcinogens/*metabolism, Cytochrome P-450 Enzyme System/biosynthesis/*metabolism, Environmental Pollution, Enzyme Induction, Female, Humans, Isoenzymes/biosynthesis/*metabolism, Kinetics, Male, Methylcholanthrene/*pharmacology, Microsomes, Liver/drug effects/*metabolism, Middle Aged, Mutagens/*metabolism, Rats, Species SpecificityPathogenicity
Enzymology3900709Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens.Oda Y, Nakamura S, Oki I, Kato T, Shinagawa HMutat Res10.1016/0165-1161(85)90062-71985Animals, Biotransformation, Carcinogens/*pharmacology, Cloning, Molecular, Escherichia coli/*genetics, Gene Expression Regulation/drug effects, *Genes, Bacterial, Male, Microsomes, Liver/metabolism, Mutagenicity Tests/*methods, Mutagens/*pharmacology, Operon, RatsPathogenicity
Pathogenicity7477054Inhibitory effect of curcumin on SOS functions induced by UV irradiation.Oda YMutat Res10.1016/0165-7992(95)00048-81995Antimutagenic Agents/*pharmacology, Bacteriophage lambda/drug effects, Coloring Agents/*pharmacology, Curcumin/*pharmacology, DNA, Bacterial/radiation effects, Dose-Response Relationship, Drug, Escherichia coli/drug effects/genetics/radiation effects, Gene Expression/drug effects, SOS Response, Genetics/*drug effects/genetics, Salmonella typhimurium/drug effects/genetics/radiation effects, Ultraviolet Rays, Virus Activation/drug effects, beta-Galactosidase/genetics
Enzymology7554070Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.Yamazaki H, Inui Y, Wrighton SA, Guengerich FP, Shimada TCarcinogenesis10.1093/carcin/16.9.21671995Adult, Antibody Specificity, Biotransformation, Carcinogens/*pharmacokinetics, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System/genetics/*metabolism, DNA, Complementary/genetics, Escherichia coli/*enzymology, Heterocyclic Compounds/pharmacokinetics, Humans, Immunoblotting, Isoenzymes/genetics/*metabolism, Microsomes, Liver/*enzymology, Mixed Function Oxygenases/genetics/metabolism, Mycotoxins/pharmacokinetics, Polycyclic Aromatic Hydrocarbons/pharmacokinetics, Prodrugs/*pharmacokinetics, Recombinant Proteins/genetics/metabolism, Salmonella typhimurium/drug effects/geneticsMetabolism
Pathogenicity7692279Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by the umu gene expression system in Salmonella typhimurium (TA1535/pSK1002).Okai Y, Higashi-Okai K, Nakamura SMutat Res10.1016/0165-7992(93)90096-e1993Antimutagenic Agents/*pharmacology, Gene Expression/drug effects, Molecular Weight, Mutagenicity Tests, Phaeophyta/*chemistry, Plant Extracts/*pharmacology, Salmonella typhimurium/drug effects, Seaweed
Enzymology7770509On the induction of protective responses in Salmonella typhimurium strain TA1535/pSK1002 by UVA (365 nm).Rahman S, Bose B, Chatterjee SNPhotochem Photobiol10.1111/j.1751-1097.1995.tb02347.x1995Bacterial Proteins/biosynthesis/genetics, DNA Replication/radiation effects, DNA-Directed DNA Polymerase, *Escherichia coli Proteins, Gene Expression/radiation effects, Genes, Bacterial/radiation effects, Kinetics, Plasmids/radiation effects, Salmonella typhimurium/growth & development/metabolism/*radiation effects, Thymidine/metabolism, *Ultraviolet Rays, beta-Galactosidase/biosynthesisMetabolism
Pathogenicity7807706[The SOS-inhibition activity of human urine investigated by umu-test--diurnal and daily changes of SOS-inhibition activity of urine].Yamamoto N, Sugiura W, Kosaka H, Nakamura SNihon Eiseigaku Zasshi10.1265/jjh.49.7911994Adult, Child, Child, Preschool, *Circadian Rhythm, Female, Furylfuramide/pharmacology, Humans, Male, Middle Aged, *Mutagenicity Tests, *SOS Response, Genetics/drug effects, *Urine
Enzymology7885366Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity.Oda Y, Yamazaki H, Watanabe M, Nohmi T, Shimada TMutat Res10.1016/0165-1161(95)90005-51995Acetyltransferases/biosynthesis/genetics, Amines/metabolism/*toxicity, Bacterial Proteins/biosynthesis, Biotransformation, Cloning, Molecular, Cytochrome P-450 Enzyme System/metabolism, DNA Damage, Enzyme Induction/drug effects, Gene Expression Regulation, Bacterial/*drug effects, Genes, Bacterial, Microsomes, Liver/enzymology, Mutagenicity Tests/*methods, Mutagens/metabolism/*toxicity, SOS Response, Genetics/genetics, Salmonella typhimurium/drug effects/*enzymology/genetics, beta-Galactosidase/biosynthesisMetabolism
Enzymology7954366Suppressive effects of the extracts of Japanese edible seaweeds on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promotor-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells.Okai Y, Higashi-Okai K, Nakamura S, Yano Y, Otani SCancer Lett10.1016/0304-3835(94)90405-719943T3 Cells, Animals, Anticarcinogenic Agents/isolation & purification/*pharmacology, Antimutagenic Agents/isolation & purification/*pharmacology, Bacterial Proteins/genetics, Carotenoids/analysis/isolation & purification, DNA-Directed DNA Polymerase, Enzyme Induction/drug effects, *Escherichia coli Proteins, Fibroblasts/drug effects/enzymology, Gene Expression Regulation, Bacterial/*drug effects, Genes, Bacterial, Methanol, Mice, Mice, Inbred BALB C, Oncogenes, Ornithine Decarboxylase/*biosynthesis, Salmonella typhimurium/drug effects/genetics/growth & development, *Seaweed/chemistry, Tetradecanoylphorbol Acetate/toxicity, Time Factors, beta CarotenePathogenicity
Enzymology7955101Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FPCarcinogenesis10.1093/carcin/15.11.25231994Amino Acid Sequence, Benzoflavones/pharmacology, Biotransformation, Carcinogens/*metabolism, Cytochrome P-450 Enzyme System/genetics/*pharmacology, Escherichia coli/enzymology/genetics, Humans, Microsomes, Liver/metabolism, Molecular Sequence Data, Mutagenicity Tests/*methods, Recombinant Proteins/pharmacologyMetabolism
Pathogenicity8019982Suppressive effects of urine on the SOS responses induced by UV and chemical mutagens.Ikemoto S, Kamizuru M, Hayahara N, Wada S, Kishimoto TCancer Lett10.1016/0304-3835(94)90156-21994Antimutagenic Agents/analysis/*pharmacology, Humans, Mitomycins/antagonists & inhibitors, *SOS Response, Genetics, Ultraviolet Rays, Urine/chemistry/*physiology, beta-Galactosidase/metabolismMetabolism
Metabolism8118930Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.Yamazaki H, Mimura M, Oda Y, Gonzalez FJ, el-Bayoumy K, Chae YH, Guengerich FP, Shimada TCarcinogenesis10.1093/carcin/15.3.4651994Animals, Cell Line, Chrysenes/*metabolism, Cytochrome P-450 Enzyme System/*metabolism, Epoxy Compounds/metabolism, Humans, Lymphocytes/enzymology, Male, Microsomes, Liver/*metabolism, Mutagenicity Tests, Rats, Salmonella typhimurium/genetics/metabolismPathogenicity
Enzymology8330339Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes.Yamazaki H, Mimura M, Oda Y, Inui Y, Shiraga T, Iwasaki K, Guengerich FP, Shimada TCarcinogenesis10.1093/carcin/14.7.12711993Animals, Benzoflavones/pharmacology, Biotransformation, Catalysis, Chrysenes/*pharmacokinetics/toxicity, Cytochrome P-450 Enzyme System/*metabolism, Drug Interactions, Humans, Isoenzymes/*metabolism, Male, Microsomes, Liver/drug effects/*enzymology/metabolism, Mixed Function Oxygenases/metabolism, Mutagens/*pharmacokinetics/toxicity, Pentachlorophenol/pharmacology, Rats, Rats, Sprague-Dawley, Salmonella typhimurium/genetics, beta-NaphthoflavoneMetabolism
Enzymology8491215Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O-acetyltransferase and nitroreductase activities.Oda Y, Yamazaki H, Watanabe M, Nohmi T, Shimada TEnviron Mol Mutagen10.1002/em.28502104071993Acetyltransferases/genetics/metabolism, Cloning, Molecular, DNA, Bacterial/drug effects, Deoxyribonuclease BamHI/metabolism, Deoxyribonucleases, Type II Site-Specific/metabolism, Enzyme Induction/drug effects, Gene Expression/*drug effects, Gene Expression Regulation, Bacterial, Genes, Bacterial, Mutagenicity Tests/*methods, Mutagens/*toxicity, Nitro Compounds/*toxicity, Nitroreductases/genetics/metabolism, Operon, Plasmids, Pyrenes/toxicity, Recombinant Fusion Proteins/*biosynthesis, Salmonella typhimurium/*drug effects/enzymology/genetics, Sensitivity and Specificity, Species Specificity, beta-Galactosidase/genetics/metabolismMetabolism
8541659Assessment of the mutagenicity of extracts of TMV-coat-protein-gene induced transgenic tomato by the umu-test.Shinmoto H, Tomizawa A, Kobori M, Tsushida T, Shinohara KBiosci Biotechnol Biochem10.1271/bbb.59.21511995Capsid/*genetics, Lycopersicon esculentum/*genetics, Mutagenicity Tests, Plant Extracts/*toxicity, Plants, Genetically Modified
Pathogenicity8564924All-trans beta-carotene enhances mitogenic responses and ornithine decarboxylase activity of BALB/c 3T3 fibroblast cells induced by tumor promoter and fetal bovine serum but suppresses mutagen-dependent umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002).Okai Y, Higashi-Okai K, Yano Y, Otani SCancer Lett10.1016/0304-3835(95)04032-319963T3 Cells/cytology/*drug effects/enzymology, Animals, Anthracenes/toxicity, Antimutagenic Agents/*pharmacology/toxicity, Bacterial Proteins/*biosynthesis/genetics, Carcinogens/*toxicity, Carotenoids/*pharmacology/toxicity, Cattle, Cell Division/drug effects, DNA/biosynthesis/drug effects, DNA-Directed DNA Polymerase, Drug Interactions, Enzyme Induction/drug effects, *Escherichia coli Proteins, Fetal Blood, Gene Expression/drug effects, Mice, Mice, Inbred BALB C, Mutagens/toxicity, Ornithine Decarboxylase/biosynthesis/drug effects/*metabolism, Salmonella typhimurium/*drug effects/*genetics/metabolism, Tetradecanoylphorbol Acetate/*toxicity, beta CaroteneMetabolism
8620448Identification of antimutagenic substances in an extract of edible red alga, Porphyra tenera (Asakusa-nori)Okai Y, Higashi-Okai K, Yano Y, Otani SCancer Lett10.1016/0304-3835(95)04101-x1996Antimutagenic Agents/*pharmacology, Carotenoids/pharmacology, Chlorophyll/pharmacology, Chlorophyll A, Lutein/pharmacology, Mutagenicity Tests, Pigments, Biological/*pharmacology, Rhodophyta/*chemistry, Seaweed/chemistry, beta Carotene
Metabolism8625454A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.Oda Y, Yamazaki H, Thier R, Ketterer B, Guengerich FP, Shimada TCarcinogenesis10.1093/carcin/17.2.29719964-Nitroquinoline-1-oxide/metabolism/toxicity, Animals, Biotransformation, Ethane/analogs & derivatives/metabolism/toxicity, Ethylene Dibromide/metabolism/toxicity, Ethylene Dichlorides/metabolism/toxicity, Fluorenes/metabolism/toxicity, Gene Expression/drug effects, Genetic Vectors/*genetics, Glutathione Transferase/genetics/*metabolism, Hydrocarbons, Halogenated/metabolism/*toxicity, Methylene Chloride/metabolism/toxicity, Methylnitronitrosoguanidine/metabolism/toxicity, Mutagenicity Tests, Operon/*genetics, Pyrenes/metabolism/toxicity, Rats, Salmonella typhimurium/classification/*drug effects/enzymology/genetics, Transfection, Transformation, BacterialPathogenicity
Enzymology8674051Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, Sutter TRCancer Res1996Adult, Amines/pharmacokinetics, Animals, Biotransformation, Carcinogens/*pharmacokinetics, Catalysis, Chrysenes/pharmacokinetics, Cytochrome P-450 Enzyme System/genetics/*metabolism, DNA, Complementary/genetics/metabolism, Humans, Isoenzymes/genetics/*metabolism, Microsomes/enzymology, Mutagens/pharmacokinetics, NADPH-Ferrihemoprotein Reductase/metabolism/pharmacology, Polycyclic Compounds/pharmacokinetics, Prodrugs/*pharmacokinetics, RNA/genetics/metabolism, Rabbits, Saccharomyces cerevisiae/enzymology/genetics, Substrate SpecificityMetabolism
Pathogenicity8684403Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002).Okai Y, Higashi-Okai K, Nakamura S, Yano Y, Otani SMutat Res10.1016/0165-1218(95)00109-31996Animals, Antimutagenic Agents/pharmacology, Antioxidants/pharmacology, Bacterial Proteins/*drug effects/genetics, Carbolines/toxicity, Carotenoids/*pharmacology, DNA-Directed DNA Polymerase, Dose-Response Relationship, Drug, *Escherichia coli Proteins, Gene Expression/*drug effects, Heterocyclic Compounds/toxicity, Liver/drug effects/enzymology, Mutagens/toxicity, Rats, Rats, Sprague-Dawley, Retinoids/*pharmacology, Salmonella typhimurium/*drug effects/genetics, Vitamins/*pharmacologyEnzymology
Metabolism8723730Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng YF, Guengerich FP, Inui YDrug Metab Dispos1996Antibodies/immunology/metabolism, Carcinogens/metabolism, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System/*metabolism, Fetus/metabolism, Gene Expression Regulation, Bacterial/genetics, Humans, Immunoblotting, Liver/metabolism, Lung/metabolism, Microsomes/chemistry/*enzymology, Oxidation-Reduction, Recombinant Proteins/chemistry/immunology/metabolism, Salmonella typhimurium/metabolism, Testosterone/metabolism, Xenobiotics/*metabolismEnzymology
Pathogenicity8830802Suppressive effects of chlorophyllin on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells.Okai Y, Higashi-Okai K, Yano Y, Otani SMutat Res10.1016/s0165-1218(96)90122-619963T3 Cells, Animals, Antimutagenic Agents/*administration & dosage, Bacterial Proteins/*antagonists & inhibitors/genetics, Chlorophyllides/*administration & dosage, DNA-Directed DNA Polymerase, Enzyme Induction/drug effects, *Escherichia coli Proteins, Gene Expression/drug effects, Mice, Mice, Inbred BALB C, Ornithine Decarboxylase/biosynthesis/genetics, *Ornithine Decarboxylase Inhibitors, Salmonella typhimurium/*genetics
Enzymology8924613Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.Shimada T, Yamazaki H, Oda Y, Hiratsuka A, Watabe T, Guengerich FPChem Res Toxicol10.1021/tx950125v1996Aflatoxin B1/metabolism, Alkanes/*pharmacokinetics, Animals, Biotransformation, Carcinogens/*pharmacokinetics, Chromatography, High Pressure Liquid, Glutathione Transferase/*toxicity, Hydrocarbons, Halogenated/*pharmacokinetics, Male, Microsomes, Liver/drug effects/enzymology/metabolism, Mutagenicity Tests, Polychlorinated Biphenyls/pharmacology, Rats, Rats, Sprague-Dawley, Salmonella typhimurium/*drug effects/geneticsMetabolism
Enzymology8962427Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays.Matsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, Sawada M, Hayashi M, Nohmi T, Yoshihira K, Ishidate M Jr, Sofuni TMutagenesis10.1093/mutage/11.6.5731996Animals, Bacillus subtilis/drug effects/genetics, Biotransformation, CHO Cells, Cricetinae, Diterpenes/pharmacokinetics/*toxicity, *Diterpenes, Kaurane, Escherichia coli/drug effects/genetics, Glucosides/pharmacokinetics/*toxicity, Male, Mice, Micronucleus Tests, Mutagenicity Tests, Salmonella typhimurium/drug effects/genetics, Sweetening Agents/pharmacokinetics/*toxicity, Terpenes/pharmacokinetics/*toxicityPathogenicity
Pathogenicity9042400Antimutagenic effect of resveratrol against Trp-P-1.Uenobe F, Nakamura S, Miyazawa MMutat Res10.1016/s0027-5107(96)00191-119974-Nitroquinoline-1-oxide/pharmacology, Antimutagenic Agents/*pharmacology, Carbolines/*pharmacology, Furylfuramide/pharmacology, Methylnitronitrosoguanidine/pharmacology, Mutagenicity Tests, Mutagens/*pharmacology, Resveratrol, SOS Response, Genetics/*drug effects, Salmonella typhimurium/genetics, Stilbenes/isolation & purification/*pharmacologyEnzymology
Metabolism9066290Induction of cell killing, mutation and umu gene expression by 6-mercaptopurine or 2-thiouracil with UVA irradiation.Komeda K, Iwamoto S, Kominami S, Ohnishi TPhotochem Photobiol10.1111/j.1751-1097.1997.tb01885.x1997Adenosine Triphosphatases/metabolism, Bacterial Proteins/*metabolism, Cell Death, *DNA Repair, DNA-Binding Proteins/metabolism, DNA-Directed DNA Polymerase, Escherichia coli, *Escherichia coli Proteins, Mercaptopurine/*pharmacology, Mutagenesis, Thiouracil/*pharmacology, Ultraviolet Rays
Enzymology9434838Increase of sensitivity and validity of the SOS/umu-test after replacement of the beta-galactosidase reporter gene with luciferase.Schmid C, Reifferscheid G, Zahn RK, Bachmann MMutat Res10.1016/s1383-5718(97)00118-61997Blotting, Western, Electrophoresis, Polyacrylamide Gel, *Genes, Reporter, Luciferases/*genetics, Reproducibility of Results, Restriction Mapping, *SOS Response, Genetics, Salmonella typhimurium/*genetics, Sensitivity and Specificity, beta-Galactosidase/*genetics
Pathogenicity9485539Potent suppressive activity of nonpolyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002), tumor promotor-dependent ornithine decarboxylase induction of BALB/c 3T3 fibroblast cells, and chemically induced mouse skin tumorigenesis.Okai Y, Higashi-Okai KTeratog Carcinog Mutagen10.1002/(SICI)1520-6866(1997)17:6<305::AID-TCM1>3.0.CO;2-L19973T3 Cells, 9,10-Dimethyl-1,2-benzanthracene, Animals, Anticarcinogenic Agents/*pharmacology, Bacterial Proteins/*genetics, DNA-Directed DNA Polymerase, Enzyme Induction/drug effects, *Escherichia coli Proteins, Female, Gene Expression/drug effects, Mice, Mice, Inbred BALB C, Ornithine Decarboxylase/*biosynthesis, Salmonella typhimurium/genetics, Skin Neoplasms/chemically induced/*prevention & control, *Tea, Tetradecanoylphorbol Acetate/toxicityGenetics
Pathogenicity9570394Potent suppressing activity of the non-polyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002)--association with pheophytins a and b.Okai Y, Higashi-Okai KCancer Lett10.1016/s0304-3835(97)00294-21997Antimutagenic Agents/*pharmacology, Bacterial Proteins/*genetics, DNA-Directed DNA Polymerase, *Escherichia coli Proteins, Gene Expression Regulation, Bacterial/*drug effects, Pheophytins/*pharmacology, SOS Response, Genetics/drug effects, Salmonella typhimurium/*genetics, Spinacia oleracea/chemistry, Tea/*chemistry
Pathogenicity9626547Correlation between on-line PAH detection in airborne particle samples and their bacterial genotoxicity.Wasserkort R, Hartmann A, Widmer RM, Burtscher HEcotoxicol Environ Saf10.1006/eesa.1998.16531998Air Pollutants/*analysis, *DNA Damage, Environmental Monitoring/*methods, Hydrocarbons, Aromatic/analysis/*toxicity, Mutagenicity Tests/methods, *Online Systems, Polycyclic Compounds/analysis/*toxicity, Salmonella typhimurium/drug effects/genetics
Pathogenicity9720227Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test.Miyazawa M, Okuno Y, Oshiro K, Kasahara H, Shimamura H, Nakamura S, Kameoka HBiosci Biotechnol Biochem1998Aflatoxin B1/*toxicity, Carbolines/*toxicity, Chloroform, DNA Damage/drug effects, Gas Chromatography-Mass Spectrometry, Guaiacol/*analogs & derivatives/isolation & purification/pharmacology, Lauraceae/*chemistry, Lignans/isolation & purification/*pharmacology, Magnetic Resonance Spectroscopy, Mutagens/*toxicity, Plant Extracts/pharmacology, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*drug effects/geneticsEnzymology
Pathogenicity10029677Studies on the genotoxicity of endosulfan in bacterial systems.Chaudhuri K, Selvaraj S, Pal AKMutat Res10.1016/s1383-5718(98)00174-01999Ampicillin/metabolism, Bacteriophage lambda/genetics, DNA Damage/genetics, DNA Repair/genetics, Drug Resistance/genetics, Endosulfan/*toxicity, Escherichia coli/*drug effects/genetics, Gene Expression/drug effects/genetics, Genes, Bacterial/genetics, Insecticides/toxicity, *Mutagenicity Tests, Mutation/genetics, Rec A Recombinases/genetics, Salmonella typhimurium/*drug effectsMetabolism
Enzymology10357791Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002.Oda Y, Yamazaki H, Shimada TCarcinogenesis10.1093/carcin/20.6.10791999Arylamine N-Acetyltransferase/*physiology, Biotransformation, Carcinogens/pharmacokinetics/*toxicity, Chrysenes/pharmacokinetics/toxicity, Fluorenes/pharmacokinetics/toxicity, Humans, Isoenzymes/*physiology, Pyrenes/pharmacokinetics/toxicity, Quinolines/pharmacokinetics/toxicity, Salmonella typhimurium/*genetics/growth & developmentPathogenicity
Enzymology10552513Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity.Miyazawa M, Shimamura H, Nakamura S, Sugiura W, Kosaka H, Kameoka HJ Agric Food Chem10.1021/jf970930a1999Antimutagenic Agents/chemistry/*isolation & purification/pharmacology, Benzyl Compounds/chemistry/*isolation & purification/pharmacology, Hexanes, Mutagenicity Tests, Plant Extracts/chemistry, Plant Stems, Plants, Medicinal/*chemistry, Salmonella typhimurium/drug effectsPhylogeny
Pathogenicity10606602Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium.Miyazawa M, Okuno Y, Fukuyama M, Nakamura S, Kosaka HJ Agric Food Chem10.1021/jf990176o1999Antimutagenic Agents/*pharmacology, Carcinogens, *Citrus, Flavonoids/*pharmacology, Furylfuramide, Gene Expression Regulation/drug effects, Humans, Plant Extracts/*chemistry, Salmonella typhimurium
Enzymology10619367In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver.Ueng YF, Chang YL, Oda Y, Park SS, Liao JF, Lin MF, Chen CFLife Sci10.1016/s0024-3205(99)00528-71999Animals, Antioxidants/pharmacokinetics/*pharmacology, Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors/*metabolism, Benzopyrene Hydroxylase/antagonists & inhibitors/metabolism, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System/*metabolism, Cytochromes b5/antagonists & inhibitors/metabolism, Dose-Response Relationship, Drug, Estrogen Antagonists/pharmacokinetics/pharmacology, *Flavanones, Flavonoids/pharmacokinetics/*pharmacology, Kinetics, Male, Mice, Mice, Inbred C57BL, Microsomes, Liver/*drug effects/*enzymologyMetabolism
Pathogenicity10725128Antimutagenic activity of flavonoids from Pogostemon cablin.Miyazawa M, Okuno Y, Nakamura S, Kosaka HJ Agric Food Chem10.1021/jf990160y2000Antimutagenic Agents/*chemistry, Flavonoids/*chemistry, Gene Expression Regulation, Bacterial, Humans, Lamiaceae/*chemistry, Plant Extracts/chemistry, Salmonella typhimurium/genetics
Pathogenicity10805996Assessment of the water-extractable genotoxic potential of soil samples from contaminated sites.Ehrlichmann H, Dott W, Eisentraeger AEcotoxicol Environ Saf10.1006/eesa.1999.18752000Escherichia coli/drug effects, Mutagens/isolation & purification/*toxicity, Salmonella typhimurium/drug effects, Soil Pollutants/isolation & purification/*toxicityEnzymology
10995366Suppression of furylfuramide-induced SOS response by acetophenones using Salmonella typhimurium TA1535/pSK1002 umu test.Miyazawa M, Shimamura H, Nakamura Si, Sugiura WJ Agric Food Chem10.1021/jf990631g2000Acetophenones/*pharmacology, Furylfuramide/*pharmacology, *SOS Response, Genetics, Salmonella typhimurium/*genetics
Pathogenicity11059851The application of reporter gene assays for the determination of the toxic potency of diffuse air pollution.Hamers T, van Schaardenburg, Felzel EC, Murk AJ, Koeman JHSci Total Environ10.1016/s0048-9697(00)00600-82000Air Pollutants/*toxicity, Animals, Bacterial Proteins/drug effects/genetics, Carcinoma, Hepatocellular/genetics, Cell Communication/drug effects, Cell Line, DNA-Directed DNA Polymerase, Dose-Response Relationship, Drug, *Escherichia coli Proteins, *Genes, Reporter, Luciferases/drug effects/genetics, Netherlands, Pilot Projects, Rats, Salmonella typhimurium/drug effects/genetics, Toxicity Tests/*methods, beta-Galactosidase/drug effects/genetics
Pathogenicity11087498Suppression of the furylfuramide-induced SOS response by monoterpenoids with a p-menthane skeleton using the Salmonella typhimurium TA1535/pSK1002 Umu test.Miyazawa M, Okuno Y, Nakamura Si, Kosaka HJ Agric Food Chem10.1021/jf00025442000Alcohols/pharmacology, Furylfuramide/*pharmacology, Menthol/*analogs & derivatives/chemistry/*pharmacology, Molecular Structure, Mutagenicity Tests, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*drug effects/genetics, Structure-Activity Relationship, Terpenes/chemistry/*pharmacology
Metabolism11113705Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi TMutat Res10.1016/s1383-5718(00)00138-82000*Aryl Hydrocarbon Hydroxylases, Biotransformation, Cytochrome P-450 CYP1A1/*metabolism, Cytochrome P-450 CYP1A2/*metabolism, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System/*metabolism, Escherichia coli/enzymology, Humans, Mutagenicity Tests, Mutagens/*pharmacokinetics/pharmacology, NADPH-Ferrihemoprotein Reductase/metabolism, Pyrenes/*pharmacokinetics/pharmacology, Recombinant Fusion Proteins/metabolism, Salmonella typhimurium/drug effects, Structure-Activity Relationship, Vehicle Emissions/analysis/*toxicityEnzymology
Pathogenicity11132519Enhancing effect of a plastic plasticizer, di-2-ethylhexyl phthalate on umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002).Okai Y, Higashi-Okai KJ UOEH10.7888/juoeh.22.3052000Animals, Bile Acids and Salts/physiology, Diethylhexyl Phthalate/*toxicity, Gene Expression Regulation, Bacterial/*drug effects, Genes, Bacterial/*genetics, Lipase/physiology, Male, Plasticizers/*toxicity, Rats, Rats, Wistar, Salmonella typhimurium/*genetics, Swine
Enzymology11170596Antimutagenic activity of isoflavone from Pueraria lobata.Miyazawa M, Sakano K, Nakamura S, Kosaka HJ Agric Food Chem10.1021/jf000255w20014-Nitroquinoline-1-oxide/pharmacology, Antimutagenic Agents/isolation & purification/*pharmacology, Chemical Fractionation, Fabaceae/*chemistry, Furylfuramide/pharmacology, Isoflavones/isolation & purification/*pharmacology, Methylation, Methylnitronitrosoguanidine/pharmacology, Plant Extracts/chemistry/*pharmacology, *Plants, Medicinal, SOS Response, Genetics/drug effects, Salmonella typhimurium/genetics, Ultraviolet RaysPhylogeny
11513704Suppression of chemical mutagen-induced SOS response by alkylphenols from clove (Syzygium aromaticum) in the Salmonella typhimurium TA1535/pSK1002 umu test.Miyazawa M, Hisama MJ Agric Food Chem10.1021/jf01034692001Chromatography, Gas, Dose-Response Relationship, Drug, Eugenol/*chemistry, Phenols/*pharmacology, SOS Response, Genetics, Salmonella typhimurium/*genetics, Syzygium/*chemistry
Metabolism11525925Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi TMutat Res10.1016/s1383-5718(01)00254-62001Acetyltransferases/genetics/metabolism, *Aryl Hydrocarbon Hydroxylases, Biotransformation, Carcinogens/*pharmacokinetics/*toxicity, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System/genetics/*metabolism, Escherichia coli/genetics, Humans, In Vitro Techniques, Microsomes, Liver/metabolism, Mutagens/*pharmacokinetics/*toxicity, NADPH-Ferrihemoprotein Reductase/genetics/metabolism, Pyrenes/*pharmacokinetics/*toxicity, Recombinant Proteins/genetics/metabolism, SOS Response, Genetics, Salmonella typhimurium/drug effects/genetics/metabolismEnzymology
Pathogenicity11751436Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust.Hatanaka N, Yamazaki H, Kizu R, Hayakawa K, Aoki Y, Iwanari M, Nakajima M, Yokoi TCarcinogenesis10.1093/carcin/22.12.20332001Animals, *Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System/genetics/*metabolism, DNA Damage/drug effects, Enzyme Induction/drug effects, Isoenzymes/genetics/metabolism, Kidney/cytology/drug effects/*enzymology, Liver/cytology/drug effects/*enzymology, Lung/cytology/drug effects/*enzymology, Male, Microsomes/drug effects/enzymology, RNA, Messenger/genetics/metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, Vehicle Emissions/*adverse effectsEnzymology
Enzymology11755119Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities.Ueng YF, Shyu CC, Liu TY, Oda Y, Lin YL, Liao JF, Chen CFBiochem Pharmacol10.1016/s0006-2952(01)00816-42001Aflatoxin B1/*toxicity, Animals, Benzo(a)pyrene/*toxicity, Diet, Drug Interactions, *Flavanones, Flavonoids/*pharmacology, Hydroxylation, Male, Mice, Mice, Inbred C57BL, Microsomes, Liver/*drug effects/enzymology/metabolism, Mutagenicity Tests, NADPH-Ferrihemoprotein Reductase/drug effects/metabolism, Protective Agents/*pharmacologyPathogenicity
Pathogenicity11827279The cytotoxic and genotoxic potential of surface water and wastewater effluents as determined by bioluminescence, umu-assays and selected biomarkers.Dizer H, Wittekindt E, Fischer B, Hansen PDChemosphere10.1016/s0045-6535(01)00062-52002Acetylcholinesterase/analysis/biosynthesis, Animals, Biomarkers/analysis, DNA/analysis, Liver, Luminescent Measurements, Muscle, Skeletal, Mutagenicity Tests, Photobacterium/drug effects/physiology, Reproducibility of Results, Salmonella typhimurium/drug effects/genetics, Sensitivity and Specificity, *Waste Disposal, Fluid, Water Pollutants, Chemical/*toxicity
Enzymology11996967Induction of SOS response in Salmonella typhimurium TA4107/pSK1002 by peroxynitrite-generating agent, N-morpholino sydnonimine.Motohashi N, Saito YMutat Res10.1016/s0027-5107(02)00025-82002Kinetics, Molsidomine/analogs & derivatives/*pharmacology, Oxidative Stress, Peroxynitrous Acid/*biosynthesis, Plasmids, *SOS Response, Genetics, Salmonella typhimurium/*genetics
Cultivation12116881Screening of Basidiomycete mushroom extracts for antigenotoxic and bio-antimutagenic activity.Filipic M, Umek A, Mlinaric APharmazie2002Antimutagenic Agents/chemistry/*pharmacology, Basidiomycota/*chemistry, Culture Media, Drug Evaluation, Preclinical, Escherichia coli/drug effects/genetics, Mutagenicity Tests, Salmonella typhimurium/drug effects/genetics, Spectrophotometry, Ultraviolet, Ultraviolet RaysPathogenicity
Enzymology12160905Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay.Takemoto K, Yamazaki H, Nakajima M, Yokoi TMutat Res10.1016/s1383-5718(02)00141-92002Animals, *Aryl Hydrocarbon Hydroxylases, Benzhydryl Compounds/*adverse effects/pharmacokinetics, Benzophenones/*adverse effects/pharmacokinetics, Carcinogens/*pharmacokinetics/*toxicity, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme System/genetics/*metabolism, Enzyme Induction, Escherichia coli/genetics, Humans, Male, Mice, Mice, Inbred C57BL, Microsomes, Liver/metabolism, Mixed Function Oxygenases/genetics/*metabolism, Mutagenicity Tests, Mutagens/*pharmacokinetics/*toxicity, NADPH-Ferrihemoprotein Reductase/genetics/metabolism, Photosensitizing Agents/*adverse effects/pharmacokinetics, Rats, Rats, Wistar, Recombinant Proteins/metabolism, SOS Response, Genetics, Salmonella typhimurium/drug effects/genetics/metabolismMetabolism
Pathogenicity12437955Effect of sample preparation on the in vitro genotoxicity of a light curable glass ionomer cement.Muller BP, Eisentrager A, Jahnen-Dechent W, Dott W, Hollender JBiomaterials10.1016/s0142-9612(02)00375-72003Animals, Biocompatible Materials/toxicity, CHO Cells, Cricetinae, Dentin-Bonding Agents/*toxicity, Glass Ionomer Cements/*toxicity, Humans, In Vitro Techniques, Light, Materials Testing, *Mutagenicity Tests, Rats, Root Canal Filling Materials/toxicity
Metabolism12742511Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds.Feng Q, Kumagai T, Nakamura Y, Uchida K, Osawa TMutat Res10.1016/s1383-5718(03)00057-32003Anthracenes/pharmacology, Antioxidants/*chemistry/pharmacology, Cell Line, Cytochrome P-450 CYP1A1/*genetics/metabolism, Cytochrome P-450 CYP1A2/*genetics/metabolism, Gallic Acid/pharmacology, Humans, Immunoblotting, Models, Chemical, *Mutagens, Phenol, Phenols/pharmacology, Salmonella typhimurium/metabolism, Tumor Cells, CulturedPathogenicity
Enzymology14526909Suppressive effect of the SOS-inducing activity of chemical mutagen by citric acid esters from Prunus mume Sieb. Et Zucc. using the Salmonella typhimurium TA1535/pSK1002 umu test.Miyazawa M, Yamada T, Utsunomiya HNat Prod Res10.1080/10575630310000725502003Antimutagenic Agents/isolation & purification/*pharmacology, Carbolines/*toxicity, Citrates/isolation & purification/*pharmacology, Citric Acid/*analogs & derivatives, *DNA Damage, Gas Chromatography-Mass Spectrometry, Magnetic Resonance Spectroscopy, Methanol, Mutagenicity Tests, Mutagens/*toxicity, Plant Extracts/pharmacology, Prunus/*chemistry, *SOS Response, Genetics, Salmonella typhimurium/genetics, SolventsPhylogeny
Enzymology14558756Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum).Miyazawa M, Hisama MJ Agric Food Chem10.1021/jf030247q2003Acrolein/analogs & derivatives, Aldehydes/isolation & purification/pharmacology, Antimutagenic Agents/*isolation & purification/*pharmacokinetics, Eugenol/analogs & derivatives/isolation & purification/pharmacology, *Lignans, Mutagenicity Tests, RNA, Messenger/biosynthesis, SOS Response, Genetics/drug effects/radiation effects, Salmonella typhimurium/genetics, Syzygium/*chemistry, Ultraviolet RaysPhylogeny
Metabolism14582383Genotoxic activities of drug-nitrite interaction products.Ozhan G, Alpertunga BDrug Chem Toxicol10.1081/dct-1200248442003Administration, Oral, Drug Interactions, *Drug-Related Side Effects and Adverse Reactions, Hydrogen-Ion Concentration, Mutagenicity Tests, Nitrites/*chemistry, Nitroso Compounds/*metabolism/*toxicity, Pharmaceutical Preparations/*metabolism, Salmonella typhimurium/geneticsPathogenicity
Pathogenicity14586095Antimutagenic activity of flavonoids from Chrysanthemum morifolium.Miyazawa M, Hisama MBiosci Biotechnol Biochem10.1271/bbb.67.20912003Antimutagenic Agents/*pharmacology, Apigenin, Chrysanthemum/*chemistry, *Flavones, Flavonoids/*pharmacology, Furylfuramide, Inhibitory Concentration 50, Luteolin, Plant Extracts/pharmacology, Quercetin, SOS Response, Genetics/drug effects, Salmonella typhimurium/drug effects/genetics
Pathogenicity14743341Use of a high-throughput umu-microplate test system for rapid detection of genotoxicity produced by mutagenic carcinogens and airborne particulate matter.Oda Y, Funasaka K, Kitano M, Nakama A, Yoshikura TEnviron Mol Mutagen10.1002/em.102092004Air Pollutants/*toxicity, Biotransformation, Carcinogens, Environmental/*toxicity, Dose-Response Relationship, Drug, Gene Expression Regulation, Bacterial/*drug effects, Genes, Bacterial/*drug effects, Mutagenicity Tests/*methods, Mutagens/toxicity, Salmonella typhimurium/*drug effects/enzymology/genetics, Sensitivity and Specificity, Transcriptional Activation, beta-Galactosidase/genetics/metabolismEnzymology
Pathogenicity15450415Inhibitory effects of water-soluble cationic manganese porphyrins on peroxynitrite-induced SOS response in Salmonella typhimurium TA4107/pSK1002.Motohashi N, Takahashi A, Mifune M, Saito YMutat Res10.1016/j.mrfmmm.2004.04.0102004Cations, Lipid Peroxidation, Manganese/chemistry, Peroxynitrous Acid/*pharmacology, Porphyrins/chemistry/*pharmacology, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*drug effects/genetics, Solubility, Spectrophotometry, Water
Pathogenicity15476194Evaluation of the Salmonella umu test with 83 NTP chemicals.Yasunaga K, Kiyonari A, Oikawa T, Abe N, Yoshikawa KEnviron Mol Mutagen10.1002/em.200532004Animals, Carcinogenicity Tests/methods, Carcinogens/*toxicity, Databases, Factual, Evaluation Studies as Topic, Genes, Bacterial/*drug effects, Inorganic Chemicals/*toxicity, Male, Microsomes, Liver/drug effects, Mutagenicity Tests/methods, Organic Chemicals/*toxicity, Rats, Rats, Sprague-Dawley, SOS Response, Genetics/drug effects/genetics, Salmonella typhimurium/*drug effects/genetics, beta-Galactosidase/genetics/metabolismMetabolism
Pathogenicity15476307Potent antioxidative and antigenotoxic activity in aqueous extract of Japanese rice bran--association with peroxidase activity.Higashi-Okai K, Kanbara K, Amano K, Hagiwara A, Sugita C, Matsumoto N, Okai YPhytother Res10.1002/ptr.15762004Antimutagenic Agents/administration & dosage/*pharmacology/therapeutic use, Antioxidants/administration & dosage/*pharmacology/therapeutic use, Bacterial Proteins/genetics, Dose-Response Relationship, Drug, Gene Expression Regulation, Bacterial/drug effects, Horseradish Peroxidase/pharmacology, Humans, *Oryza, *Phytotherapy, Plant Extracts/administration & dosage/*pharmacology/therapeutic use, SOS Response, Genetics, Salmonella typhimurium/*drug effects/genetics
Metabolism15568779Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.Okuno Y, Miyazawa MJ Nat Prod10.1021/np034007g2004Aspergillus niger/*metabolism, Biotransformation, Citrus/chemistry, Flavones/*metabolism, Flavonoids/chemistry/*pharmacology, Furylfuramide/*pharmacology, Molecular Structure, Mutagenicity Tests, Plants, Medicinal/chemistry/*metabolism, *SOS Response, Genetics, Salmonella typhimurium/*genetics/radiation effects
Pathogenicity15630264Effects of diet composition on mutagenic activity in urine.Ohara A, Matsuhisa TBiofactors10.1002/biof.55202201222004Cooking, *Diet, Feeding Behavior, Humans, Mutagens/*analysis/*pharmacology, SOS Response, Genetics/drug effects, Salmonella typhimurium/drug effects/*genetics, Smoking/urine
Pathogenicity15700642Suppression of chemical mutagen-induced SOS response by allylbenzen from Asiasarum heterotropoides in the Salmonella typhimurium TA1535/PSK1002 umu test.Miyazawa M, Kohno GNat Prod Res10.1080/147864103100016438582005Allyl Compounds/administration & dosage/pharmacology/therapeutic use, Antimutagenic Agents/administration & dosage/*pharmacology/therapeutic use, *Aristolochiaceae, Benzene Derivatives/administration & dosage/pharmacology/therapeutic use, Humans, Mutagenicity Tests, Mutagens/toxicity, *Phytotherapy, Plant Extracts/administration & dosage/*pharmacology/therapeutic use, Quinolines/toxicity, *SOS Response, Genetics, Salmonella typhimurium/*genetics
Pathogenicity15769173Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test.Miyazawa M, Okuno Y, Imanishi KJ Agric Food Chem10.1021/jf035430y2005Carbolines/*antagonists & inhibitors/pharmacology, *Mutagenicity Tests, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*genetics, Triterpenes/*pharmacology, Uncaria/*chemistry
Enzymology15970438Electrochemical mutagen screening using microbial chip.Matsui N, Kaya T, Nagamine K, Yasukawa T, Shiku H, Matsue TBiosens Bioelectron10.1016/j.bios.2005.05.0042005Biological Assay/*instrumentation/methods, Biosensing Techniques/instrumentation/methods, Electrochemistry/*instrumentation/methods, Equipment Design, Equipment Failure Analysis, Escherichia coli/*drug effects/*enzymology, Mutagens/*administration & dosage/*analysis, Reproducibility of Results, Salmonella typhimurium/*drug effects/enzymology, Sensitivity and Specificity, beta-Galactosidase/analysisPathogenicity
Pathogenicity16079535Antioxidant effects of hydroxybenzalacetones on peroxynitrite-induced lipid peroxidation in red blood cell membrane ghost and SOS response in Salmonella typhimurium TA4107/pSK1002.Motohashi N, Takahashi A, Yamagami C, Saito YChem Pharm Bull (Tokyo)10.1248/cpb.53.10032005Antioxidants/*pharmacology, Butanones/chemistry/*pharmacology, Erythrocyte Membrane/*drug effects/metabolism, Lipid Peroxidation/*drug effects, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*drug effectsMetabolism
Phylogeny16707328Different results of the Salmonella umu test between three isomers of phenylenediamine (PDA) derivatives.Yasunaga K, Kiyonari A, Nakagawa M, Yoshikawa KDrug Chem Toxicol10.1080/014805406005667662006Animals, Dose-Response Relationship, Drug, Male, *Mutagenicity Tests, Mutagens/classification/*toxicity, Phenylenediamines/chemistry/classification/*toxicity, Rats, Rats, Sprague-Dawley, Ribosomal Protein S9, Ribosomal Proteins, SOS Response, Genetics/*drug effects/genetics, Salmonella/*drug effects/genetics, Stereoisomerism, Structure-Activity RelationshipPathogenicity
Pathogenicity16753216Ecotoxicological assessment of PAHs and their dead-end metabolites after degradation by Mycobacterium sp. strain SNP11.Pagnout C, Rast C, Veber AM, Poupin P, Ferard JFEcotoxicol Environ Saf10.1016/j.ecoenv.2006.03.0052006Aliivibrio fischeri/drug effects, Animals, Biodegradation, Environmental, Chromatography, High Pressure Liquid, Crustacea/drug effects, *Ecosystem, Eukaryota/drug effects, Molecular Weight, Mycobacterium/*growth & development, Polycyclic Aromatic Hydrocarbons/*analysis/pharmacokinetics/toxicity, Salmonella typhimurium/drug effects, *Soil Microbiology, Soil Pollutants/*analysis/pharmacokinetics/toxicityEnzymology
Pathogenicity17051817Genotoxic risk identification of soil contamination at a major industrialized city in northeast China by a combination of in vitro and in vivo bioassays.Xiao RY, Wang Z, Wang CX, Yu G, Zhu YGEnviron Sci Technol10.1021/es06073352006Animals, *Biological Assay, China, DDT/analysis/toxicity, DNA Damage, Hexachlorocyclohexane/analysis/toxicity, Mutagenicity Tests, Mutagens/analysis/*toxicity, Oligochaeta/*drug effects/physiology, Polycyclic Aromatic Hydrocarbons/analysis/toxicity, SOS Response, Genetics, Salmonella typhimurium/*drug effects/genetics/metabolism, Soil Pollutants/analysis/*toxicity, beta-Galactosidase/metabolismMetabolism
Metabolism17561780Reed beds receiving industrial sludge containing nitroaromatic compounds. Effects of outgoing water and bed material extracts in the umu-c genotoxicity assay, DR-CALUX assay and on early life stage development in zebrafish (Danio rerio).Gustavsson L, Hollert H, Jonsson S, van Bavel B, Engwall MEnviron Sci Pollut Res Int10.1065/espr2006.11.3602007Animals, Biodegradation, Environmental, Gas Chromatography-Mass Spectrometry, *Industrial Waste, Mutagenicity Tests, Nitrogen Compounds/chemistry/metabolism/*toxicity, Ovum/drug effects/growth & development, Plants/metabolism, Salmonella typhimurium/drug effects/genetics, Sewage/*chemistry, Sweden, Water Movements, Water Pollutants, Chemical/chemistry/metabolism/*toxicity, Water Purification, *Wetlands, Zebrafish/*embryologyPathogenicity
Pathogenicity17654284Suppressive components in rice husk against mutagens-induced SOS response using Salmonella typhimurium TA1535/pSK1002 umu test.Okuno Y, Miyazawa MNat Prod Res10.1080/147864107012563582007Carbolines, Mutagenicity Tests, Oryza/*chemistry, Plant Extracts/*pharmacology, SOS Response, Genetics/*drug effects, Salmonella typhimurium/*drug effects
Pathogenicity18520139Antimutagenic activity of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate.Hisama M, Matsuda S, Shibayama H, Iwaki MYakugaku Zasshi10.1248/yakushi.128.9332008Ascorbic Acid/*analogs & derivatives/chemical synthesis/pharmacology, Carbolines, Depression, Chemical, Dose-Response Relationship, Drug, Methylnitronitrosoguanidine, Mutagenesis/*drug effects/radiation effects, Mutagenicity Tests/methods, Mutagens, Salmonella typhimurium/*genetics/radiation effects, Ultraviolet Rays/adverse effects
Pathogenicity18536507Suppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test.Hisama M, Matsuda S, Tanaka T, Shibayama H, Nomura M, Iwaki MJ Oleo Sci10.5650/jos.57.38120084-Nitroquinoline-1-oxide/toxicity, Antimutagenic Agents/*pharmacology, Carbolines/toxicity, Furylfuramide/toxicity, Gas Chromatography-Mass Spectrometry, Methylnitronitrosoguanidine/toxicity, Mutagenicity Tests, Mutagens/*toxicity, SOS Response, Genetics/*drug effects/radiation effects, Salmonella typhimurium/*drug effects/radiation effects, Solutions, Ultraviolet Rays
Metabolism18562244Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains.Oda Y, Watanabe T, Terao Y, Nukaya H, Wakabayashi KMutat Res10.1016/j.mrgentox.2008.04.0132008Animals, *Arylamine N-Acetyltransferase/genetics/metabolism, Benzoflavones/pharmacology, Catalysis, *Cytochrome P-450 CYP1A1/genetics/metabolism, Dose-Response Relationship, Drug, Gene Expression/drug effects, Humans, Isoenzymes/genetics/metabolism, Molecular Structure, Mutagens/chemistry/*toxicity, Rats, Recombinant Proteins/genetics/metabolism, *SOS Response, Genetics, Salmonella typhimurium/*genetics, Structure-Activity Relationship, Triazoles/chemistry/*toxicityPathogenicity
Enzymology19054546Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays.Cao N, Yang M, Zhang Y, Hu J, Ike M, Hirotsuji J, Matsui H, Inoue D, Sei KSci Total Environ10.1016/j.scitotenv.2008.10.0482008Animals, Biological Assay, Chlorine/chemistry, Daphnia, Female, Mutagenicity Tests, Oryzias, Ozone/chemistry, Ultrafiltration/methods, Ultraviolet Rays, Waste Disposal, Fluid/*methods/*standards, Water Purification/*methods/*standards
Metabolism19237238Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5.Li W, Dai Y, Xue B, Li Y, Peng X, Zhang J, Yan YJ Hazard Mater10.1016/j.jhazmat.2008.12.1112008Achromobacter denitrificans/*metabolism, *Biodegradation, Environmental, Chromatography, High Pressure Liquid, Decontamination, Endosulfan/*metabolism/toxicity, Salmonella typhimurium/metabolism, Soil Microbiology, Soil Pollutants/*metabolism
Pathogenicity19307011Combination of in vitro bioassays for the determination of cytotoxic and genotoxic potential of wastewater, surface water and drinking water samples.Zegura B, Heath E, Cernosa A, Filipic MChemosphere10.1016/j.chemosphere.2009.02.0412009Biological Assay, Cell Line, Tumor, Comet Assay, Cytotoxins/*toxicity, Environmental Monitoring, Fresh Water/*analysis, Humans, Industrial Waste, Medical Waste, Mutagenicity Tests, Mutagens/*toxicity, Rivers, Salmonella typhimurium/drug effects, Sewage/*analysis, Waste Disposal, Fluid, Water Pollutants/pharmacology/*toxicityBiotechnology
Enzymology19393727Genotoxic activation of the environmental pollutant 3,6-dinitrobenzo[e]pyrene in Salmonella typhimurium umu strains expressing human cytochrome P450 and N-acetyltransferase.Oda Y, Hirayama T, Watanabe TToxicol Lett10.1016/j.toxlet.2009.04.0102009Acetyltransferases/*biosynthesis/genetics, Benzo(a)pyrene/*analogs & derivatives/metabolism/toxicity, Cloning, Molecular, Cytochrome P-450 Enzyme System/*biosynthesis/genetics, Dose-Response Relationship, Drug, Gene Expression/drug effects, Humans, Mutagens/metabolism/*toxicity, Nitroreductases/biosynthesis/genetics, Salmonella typhimurium/*drug effects/enzymology/genetics/growth & development, Soil Pollutants/metabolism/*toxicityPathogenicity
Enzymology20108941Suppression of SOS-inducing activity of chemical mutagens by metabolites from microbial transformation of (-)-isolongifolene.Sakata K, Oda Y, Miyazawa MJ Agric Food Chem10.1021/jf903651c2010Aflatoxin B1/pharmacology, Biotransformation, DNA Damage, DNA Replication, Furylfuramide/pharmacology, Kinetics, Magnetic Resonance Spectroscopy, Mutagens/isolation & purification/*pharmacology, Phyllachorales/metabolism, Pinus, SOS Response, Genetics/*drug effects, Salmonella typhimurium/drug effects/genetics/metabolism, Sesquiterpenes/chemistry/isolation & purification/*metabolismMetabolism
Metabolism20662538Suppression of SOS-inducing activity of chemical mutagens by metabolites from microbial transformation of (+)-longicyclene.Sakata K, Miyazawa MJ Agric Food Chem10.1021/jf101846p2010Acrylamide/toxicity, Aflatoxin B1/toxicity, Antimutagenic Agents/*metabolism/pharmacology, Magnetic Resonance Spectroscopy, Mutagens/*toxicity, SOS Response, Genetics/*drug effects, Salmonella typhimurium/drug effects/genetics, Sesquiterpenes/*metabolism/pharmacology, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, InfraredPathogenicity
Pathogenicity21187829Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test.Sieroslawska A, Rymuszka ANeuro Endocrinol LettNEL31S210A042010Animals, Cyanobacteria Toxins, Dose-Response Relationship, Drug, Genes, Bacterial/*drug effects, Marine Toxins, Metabolism/drug effects, Microcystins/pharmacology, Mutagenicity Tests, Neurotoxins/*pharmacology, Salmonella typhimurium/*genetics, Tropanes/*pharmacologyMetabolism
21781790The genotoxicity of diaveridine and trimethoprim.Ono T, Sekiya T, Takahashi Y, Sasaki YF, Izumiyama F, Nishidate E, Tsuda S, Ohta TEnviron Toxicol Pharmacol10.1016/s1382-6689(97)00026-41997
Pathogenicity22072630Roles of human sulfotransferases in genotoxicity of carcinogens using genetically engineered umu test strains.Oda Y, Zhang Y, Buchinger S, Reifferscheid G, Yang MEnviron Mol Mutagen10.1002/em.206962011Amines/pharmacology, Carcinogens/*toxicity, Genetic Engineering, Humans, Mutagens/*toxicity, Plasmids/genetics, Salmonella typhimurium/*drug effects/enzymology/*genetics, Sensitivity and Specificity, Sulfotransferases/genetics/*metabolismEnzymology
Pathogenicity22483724Contributions of flumequine and nitroarenes to the genotoxicity of river and ground waters.Ma F, Yuan G, Meng L, Oda Y, Hu JChemosphere10.1016/j.chemosphere.2012.02.0802012Biological Assay, Fluoroquinolones/analysis/*toxicity, Groundwater/*chemistry, Mutagens/analysis/*toxicity, Nitro Compounds/analysis/*toxicity, Rivers/*chemistry, Salmonella typhimurium/drug effects/genetics
Pathogenicity22785478Facile synthesis of 4-O-beta-N-acetylchitooligosyl 2-acetamido-2,3-dideoxydidehydro-gluconolactone based on the transformation of chitooligosaccharide and its suppressive effects against the furylfuramide-induced SOS response.Ogata M, Takeuchi R, Suzuki A, Hirai H, Usui TBiosci Biotechnol Biochem10.1271/bbb.1201192012Antimutagenic Agents/*chemical synthesis/pharmacology, Chitin/chemistry, Chromatography, High Pressure Liquid, Furylfuramide/*pharmacology, Microbial Sensitivity Tests, Mutagens/*pharmacology, Oligosaccharides/*chemical synthesis/chemistry/pharmacology, Oxidation-Reduction, SOS Response, Genetics/drug effects, Salmonella typhimurium/*drug effects/growth & development
24278503Antimutagenic and Anticarcinogenic Effect of Methanol Extracts of Sweetpotato (Ipomea batata) Leaves.Kang HG, Jeong SH, Cho JHToxicol Res10.5487/TR.2010.26.1.0292010
Pathogenicity24478133Application of the SOS/umu test and high-content in vitro micronucleus test to determine genotoxicity and cytotoxicity of nine benzothiazoles.Ye Y, Weiwei J, Na L, Mei M, Kaifeng R, Zijian WJ Appl Toxicol10.1002/jat.29722014Benzothiazoles/chemistry/*toxicity, Cell Culture Techniques, Cell Line, Tumor, Cell Survival/drug effects/genetics, *DNA Damage, Dose-Response Relationship, Drug, Humans, Inhibitory Concentration 50, Micronuclei, Chromosome-Defective/*chemically induced, Micronucleus Tests, Molecular Structure, Mutagens/chemistry/*toxicity, *SOS Response, Genetics, Salmonella typhimurium/*drug effects/genetics
Pathogenicity26188195Comparative cytotoxic and genotoxic potential of 13 drinking water disinfection by-products using a microplate-based cytotoxicity assay and a developed SOS/umu assay.Zhang SH, Miao DY, Tan L, Liu AL, Lu WQMutagenesis10.1093/mutage/gev0532015Acetates/toxicity, Acetonitriles/toxicity, DNA Damage, *Disinfection, Drinking Water/*chemistry, Furans/toxicity, *Mutagenicity Tests, Mutagens/*toxicity, Salmonella typhimurium/drug effects/*genetics, Water Pollutants, Chemical/*toxicity
27003173Evaluation of Protective Effects of Bioactive Phytochemicals Against Methotrexate in Salmonella typhimurium TA1535/pSK1002 Coupled with Micronucleus Assay.Wu Y, Gu SB, Li H, He JY, Li L, Yang JBBiomed Environ Sci10.3967/bes2016.0172016Animals, Antimetabolites, Antineoplastic/*adverse effects, *Cytoprotection, Drug Evaluation, Preclinical, Female, Male, Methotrexate/*adverse effects, Mice, Micronucleus Tests, *Phytotherapy, *Plant Extracts, Random Allocation, Salmonella typhimurium
Pathogenicity27137670Assessment of the mutagenic and genotoxic activity of cyanobacterial toxin beta-N-methyl-amino-L-alanine in Salmonella typhimurium.Novak M, Hercog K, Zegura BToxicon10.1016/j.toxicon.2016.04.0472016Activation, Metabolic, Amino Acids, Diamino/metabolism/*toxicity, Animals, Bacterial Proteins/genetics/metabolism, Bacterial Toxins/metabolism/*toxicity, Cyanobacteria/*metabolism, Cyanobacteria Toxins, *DNA Damage, Marine Toxins/biosynthesis/toxicity, Microbial Viability/drug effects, Microsomes, Liver/enzymology, Mutagenicity Tests, Mutagens/*toxicity, Mutation/drug effects, Neurotoxins/metabolism/*toxicity, Osmolar Concentration, Rats, Salmonella typhimurium/*drug effects, Water Pollutants/metabolism/toxicityMetabolism
27397003Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test.Miyazawa M, Okuno Y, Oshiro K, Kasahara H, Shimamura H, Nakamura S, Kameoka HBiosci Biotechnol Biochem10.1271/bbb.62.14251998
Pathogenicity27450952Evaluation of genotoxic potential throughout the upper and middle stretches of Adige river basin.Kracun-Kolarevic M, Kolarevic S, Jovanovic J, Markovic V, Ilic M, Simonovic P, Simic V, Gacic Z, Diamantini E, Stella E, Petrovic M, Majone B, Bellin A, Paunovic M, Vukovic-Gacic BSci Total Environ10.1016/j.scitotenv.2016.07.0992016Animals, Comet Assay, Environmental Monitoring, Italy, Micronucleus Tests, Mutagens/*toxicity, Rivers/*chemistry, Salmonella typhimurium/*drug effects, Trout/*blood, Water Pollutants, Chemical/*toxicity
Pathogenicity27631093Evaluation of Genotoxic Pressure along the Sava River.Kolarevic S, Aborgiba M, Kracun-Kolarevic M, Kostic J, Simonovic P, Simic V, Miloskovic A, Reischer G, Farnleitner A, Gacic Z, Milacic R, Zuliani T, Vidmar J, Pergal M, Piria M, Paunovic M, Vukovic-Gacic BPLoS One10.1371/journal.pone.01624502016Animals, Europe, Fishes, Mutagenicity Tests, Mutagens/*toxicity, Rivers, SOS Response, Genetics, Salmonella typhimurium/drug effects/genetics, Water Pollutants, Chemical/*toxicity
27980699Development and progress for three decades in umu test systems.Oda YGenes Environ10.1186/s41021-016-0054-82016
Pathogenicity29056382Evaluation of genotoxic potential in the Velika Morava River Basin in vitro and in situ.Jovanovic J, Kolarevic S, Miloskovic A, Radojkovic N, Simic V, Dojcinovic B, Kracun-Kolarevic M, Paunovic M, Kostic J, Sunjog K, Timilijic J, Djordjevic J, Gacic Z, Zegura B, Vukovic-Gacic BSci Total Environ10.1016/j.scitotenv.2017.10.0992017Animals, Comet Assay, Cyprinidae, DNA Damage, *Environmental Monitoring, Erythrocytes/drug effects, Hep G2 Cells, Humans, Metals, Heavy/analysis, Micronucleus Tests, Rivers/*chemistry, Serbia, Water Pollutants, Chemical/*toxicity
Pathogenicity29156348Development of photoprotective, antiphototoxic, and antiphotogenotoxic formulations of ocular drugs with fluoroquinolones.Zgadzaj A, Kornacka J, Jastrzebska A, Parzonko A, Sommer S, Nalecz-Jawecki GJ Photochem Photobiol B10.1016/j.jphotobiol.2017.11.0112017Animals, Cell Line, Cell Survival/drug effects/radiation effects, Coumaric Acids, Cricetinae, Cricetulus, DNA Damage/drug effects/radiation effects, *Drug Compounding, Fleroxacin/chemistry/toxicity, Fluoroquinolones/*chemistry/toxicity, Micronucleus Tests, Photolysis/drug effects/radiation effects, Propionates/chemistry, Protective Agents/*chemistry/pharmacology, Salmonella typhimurium/drug effects/genetics, Ultraviolet Rays
Enzymology29183163Antimutagenic activity of flavonoids from Sozuku.Okuno Y, Marumoto S, Miyazawa MNat Prod Res10.1080/14786419.2017.14081042017Alpinia/*chemistry, Antimutagenic Agents/isolation & purification/*pharmacology, Chalcones/isolation & purification/pharmacology, Drugs, Chinese Herbal/*pharmacology, Flavanones/isolation & purification/pharmacology, Flavonoids/isolation & purification/*pharmacology, Furylfuramide, Mutagenicity Tests, Mutagens, Phytochemicals/isolation & purification/pharmacology, Plant Extracts/pharmacology, Quinolines, *SOS Response, Genetics, Salmonella typhimurium/*drug effects, Seeds/chemistryPhylogeny
Pathogenicity29299944Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.Kolarevic S, Milovanovic D, Kracun-Kolarevic M, Kostic J, Sunjog K, Martinovic R, Dordevic J, Novakovic I, Sladic D, Vukovic-Gacic BDrug Chem Toxicol10.1080/01480545.2017.14131082018A549 Cells, Cell Line, Tumor, Comet Assay, Cyclohexenes/*toxicity, DNA Damage, Humans, Male, Mutagens/toxicity, Salmonella typhimurium/drug effects, Sesquiterpenes/*toxicity, Toxicity Tests
Pathogenicity29600754In vitro Cytotoxicity and Genotoxicity Analysis of Ten Tannery Chemicals Using SOS/umu Tests and High-content In vitro Micronucleus Tests.Huang Z, Li N, Rao K, Liu C, Wang Z, Ma MComb Chem High Throughput Screen10.2174/13862073216661803301202482018Animals, Cell Line, China, Chromosomes/drug effects, DNA Damage/drug effects, Hazardous Substances/*pharmacology/toxicity, Humans, *Micronucleus Tests, Mutagens, Quantitative Structure-Activity Relationship, Salmonella typhimurium/drug effects, Tanning/*methods
Pathogenicity30257571Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.Dordevic J, Kolarevic S, Jovanovic J, Kostic-Vukovic J, Novakovic I, Jeremic M, Sladic D, Vukovic-Gacic BDrug Chem Toxicol10.1080/01480545.2018.15140432018Benzoquinones/*toxicity, Cells, Cultured, Comet Assay, *DNA Damage, Hep G2 Cells, Humans, Plasmids/genetics, Salmonella typhimurium/drug effects/genetics
Pathogenicity31813906In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient.Kawanishi M, Hisatomi Y, Oda Y, Shimohara C, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, Watanabe KJ Toxicol Sci10.2131/jts.44.8712019Aged, Animals, CHO Cells, Colon/*microbiology, Colorectal Neoplasms/*microbiology, Cricetulus, DNA Breaks, Double-Stranded/drug effects, Escherichia coli/genetics/*isolation & purification/metabolism, Humans, Male, Micronuclei, Chromosome-Defective/chemically induced, Mutagens/metabolism/*toxicity, Peptides/metabolism/*toxicity, Polyketides/metabolism/*toxicity, Salmonella typhimurium/drug effects/geneticsMetabolism
Pathogenicity32298276Antimutagenic, antigenotoxic and antiproliferative activities of Fraxinus angustifolia Vahl. leaves and stem bark extracts and their phytochemical composition.Bouguellid G, Russo C, Lavorgna M, Piscitelli C, Ayouni K, Wilson E, Kim HK, Verpoorte R, Choi YH, Kilani-Atmani D, Atmani D, Isidori MPLoS One10.1371/journal.pone.02306902020Antimutagenic Agents/*pharmacology, Cell Proliferation/drug effects, Fraxinus/*chemistry, Hep G2 Cells, Humans, MCF-7 Cells, Mutagens/*toxicity, Plant Bark/*chemistry, Plant Extracts/*pharmacology, Plant Leaves/*chemistry
Stress33424252The impact of different extracts of six Lamiaceae species on deleterious effects of oxidative stress assessed in acellular, prokaryotic and eukaryotic models in vitro.Oalde MM, Kolarevic SM, Zivkovic JC, Vukovic-Gacic BS, Jovanovic Maric JM, Kracun Kolarevic MJ, Dordevic JZ, Alimpic Aradski AZ, Marin PD, Savikin KP, Duletic-Lausevic SNSaudi Pharm J10.1016/j.jsps.2020.10.0062020
Pathogenicity33877247A comprehensive assessment of the chemical composition, antioxidant, genoprotective and antigenotoxic activities of Lamiaceae species using different experimental models in vitro.Oalde M, Kolarevic S, Zivkovic J, Alimpic Aradski A, Jovanovic Maric J, Kracun Kolarevic M, Dordevic J, Marin PD, Savikin K, Vukovic-Gacic B, Duletic-Lausevic SFood Funct10.1039/d1fo00447f2021Antimutagenic Agents/*pharmacology, Antioxidants/*pharmacology, DNA Damage/drug effects, DNA Repair, Fibroblasts/drug effects, Flavonoids/analysis, Humans, Lamiaceae/*chemistry, Mutagenicity Tests, Oxidative Stress/drug effects, Plant Extracts/*chemistry, Polyphenols/analysis, Salmonella typhimurium/metabolismMetabolism
34834669A Study of Phytochemistry, Genoprotective Activity, and Antitumor Effects of Extracts of the Selected Lamiaceae Species.Oalde Pavlovic M, Kolarevic S, Dordevic J, Jovanovic Maric J, Lunic T, Mandic M, Kracun Kolarevic M, Zivkovic J, Alimpic Aradski A, Marin PD, Savikin K, Vukovic-Gacic B, Bozic Nedeljkovic B, Duletic-Lausevic SPlants (Basel)10.3390/plants101123062021

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68368Automatically annotated from API 20E