Haemophilus influenzae (CCUG 29539, DSM 11970, ATCC 49766)

Name: Haemophilus influenzae (CCUG 29539, DSM 11970, ATCC 49766)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 11703

Type strain

Strain Designation L-378

Culture col. no. CCUG 29539 DSM 11970 ATCC 49766 L-378 CIP 103570 2 more

NCBI tax ID(s) 727

Special Collections DSMZ CCUG CIP

History <- Heinrich Mack Nachf.; ATCC 49766 <- ATCC; ATCC 49766 <- J. H. Jorgensen; L-378 <- S. Farmer; CIP <- 1992, J.H. Jorgensen, Univ. Texas Hlth. Sci. Center, San-Antonio, Texas, USA <- 1986, S. Farmer, Med. College Wisconsin, USA

Links

Haemophilus influenzae L-378 is a microaerophile, Gram-negative, rod-shaped bacterium that was isolated from lung abcess.

Gram-negative rod-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 7367

LMG 13189,ATCC 49766,CCUG 29539,CIP 103570,CCM 4457,NCTC 12975,DSM 11970,CNCTC 5105,BCRC 17029,CCRC 17029,ACM 5055

@ref 20215

Last LPSN update 2026-02-09 11:20:38

Domain Bacteria

Phylum Pseudomonadota

Class Gammaproteobacteria

Order Pasteurellales

Family Pasteurellaceae

Genus Haemophilus

Species Haemophilus influenzae

Full scientific name Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980)

Synonyms (2)

Hemophilus influenzae
"Bacterium influenzae"

BacDive ID	Other strains from **Haemophilus influenzae** (223)	Type strain
11698	H. influenzae 680, DSM 4690, ATCC 33391, NCTC 8143, JCM ... (type strain)
11699	H. influenzae 644, HK 403, DSM 10000, ATCC 9833, NCTC 8473, ...
11700	H. influenzae 641, CCUG 7317 A, DSM 10001, ATCC 9795, NCTC ...
11701	H. influenzae KW20, Rd, Rd KW20, DSM 11121, ATCC 51907, ...
11702	H. influenzae 572, LRA 026 05 90, DSM 11969, ATCC 10211, ...
11704	H. influenzae Kilian HK 394, Pittman 576, 576, HK 394, ...
11705	H. influenzae TD-4, DSM 24049, ATCC 49247, CCUG 26214, ...
11706	H. influenzae DSM 25829, NCCP 13792
134548	H. influenzae 390, CIP 54.81, ATCC 9006, NCTC 8465, CCUG ...
134953	H. influenzae CNRH 00043, CIP 107148
134954	H. influenzae CNRH 97765, CIP 107149
134955	H. influenzae CNRH 00519, CIP 107152
134956	H. influenzae CNRH 00214, CIP 107153
134957	H. influenzae CNRH 00587, CIP 107154
134958	H. influenzae CNRH 99484, CIP 107155
134959	H. influenzae CNRH 00071, CIP 107156
134970	H. influenzae 57.87, CIP 102803
135030	H. influenzae MJD 74396, CIP 107299
135126	H. influenzae CIP 52.93
135473	H. influenzae 23.83, CIP 100032
135479	H. influenzae 24.83, CIP 100033
135851	H. influenzae 972.85, CIP 102016
135858	H. influenzae 161-86, CIP 102216
135871	H. influenzae 10 N, CIP 103722, CCUG 31339
135976	H. influenzae 795.85, CIP 101931
136037	H. influenzae 1013.85, CIP 102033
136053	H. influenzae 123-86, CIP 102173
136069	H. influenzae 260-86, CIP 102291
136084	H. influenzae 368-86, CIP 102381
136110	H. influenzae CIP 52.154
136113	H. influenzae 570.86, CIP 102587
136137	H. influenzae 19.87, CIP 102777
136273	H. influenzae CIP A54
136428	H. influenzae 398, Rd, CIP 54.24
136435	H. influenzae Coton, CIP A70
136596	H. influenzae 357-86, CIP 102368
136623	H. influenzae CNRH 91392, CIP 107157
136624	H. influenzae CNRH 00100, CIP 107144
136625	H. influenzae CNRH 00700, CIP 107145
136626	H. influenzae CNRH 93349, CIP 107146
136793	H. influenzae CIP 52.151
136817	H. influenzae KW 21, CIP 104418
137221	H. influenzae CIP 52.202
137251	H. influenzae AmMS 120, CIP 103661, ATCC 49144
137297	H. influenzae Rb, 395, CIP 54.23
137552	H. influenzae ME870, CIP 107158
137646	H. influenzae II 86 190, LRA 020 12 87, CIP 103712
137647	H. influenzae 16 N, CIP 103723, CCUG 31340
137717	H. influenzae 624, 396, CIP 54.82, ATCC 9007, NCTC 8469, ...
137755	H. influenzae 965.83, CIP 100606
137839	H. influenzae 796.84, CIP 101171
137857	H. influenzae 812.85, CIP 101921
137874	H. influenzae 950.85, CIP 102014
137888	H. influenzae 397, 37-86, CIP 102119
137890	H. influenzae 36-86, CIP 102121
137900	H. influenzae 84-86, CIP 102147
137929	H. influenzae 186-86, CIP 102224
137930	H. influenzae 187-86, CIP 102227
137953	H. influenzae 243-86, CIP 102284
137987	H. influenzae 384-86, CIP 102390
138515	H. influenzae CNRH 00498, CIP 107150
138516	H. influenzae CNRH 00763, CIP 107151
138586	H. influenzae 97371, CIP 105280
138599	H. influenzae 511.85, CIP 101713
138621	H. influenzae 766.85, CIP 101906
138646	H. influenzae 153.87, CIP 102889
138678	H. influenzae 86242, CIP 104278
138708	H. influenzae 258-86, CIP 102295
138729	H. influenzae CIP 52.143
138737	H. influenzae CIP 52.153
138738	H. influenzae CIP 52.155
138757	H. influenzae CNRH 99024, CIP 107147
138759	H. influenzae 125.87, CIP 102873
139037	H. influenzae CIP 57.38
139079	H. influenzae 717.84, CIP 101083
139182	H. influenzae 447.84, CIP 100923
139186	H. influenzae 547.84, CIP 101002
139300	H. influenzae 118, CIP 54.83
139308	H. influenzae 595, CIP 54.84, ATCC 8142, NCTC 8472, CCUG ...
139404	H. influenzae 97393, CIP 105281
139453	H. influenzae CIP 103777, ATCC 35056
139566	H. influenzae CIP 52.152
141207	H. influenzae CCUG 188, NCTC 8455, CCUG 15444, MCCM 02079
141342	H. influenzae CCUG 1132
141344	H. influenzae CCUG 1137
141345	H. influenzae CCUG 1140
141347	H. influenzae CCUG 1147
141348	H. influenzae CCUG 1150
141349	H. influenzae CCUG 1152
141357	H. influenzae CCUG 1179
141358	H. influenzae CCUG 1180
141359	H. influenzae CCUG 1181
141390	H. influenzae CCUG 1378
141408	H. influenzae CCUG 1485
141424	H. influenzae CCUG 1709
141426	H. influenzae CCUG 1735
141446	H. influenzae CCUG 1892
141586	H. influenzae CCUG 3332
141587	H. influenzae CCUG 3333
141610	H. influenzae CCUG 3633
141615	H. influenzae CCUG 3725
141649	H. influenzae CCUG 4373
141660	H. influenzae CCUG 4512 B
141662	H. influenzae CCUG 4559
141693	H. influenzae CCUG 4852
141710	H. influenzae CCUG 5055
141742	H. influenzae CCUG 5905
141790	H. influenzae CCUG 6878
141791	H. influenzae CCUG 6879
141792	H. influenzae CCUG 6880
141793	H. influenzae CCUG 6881
141822	H. influenzae CCUG 7316, ATCC 19418, NCTC 4560
141829	H. influenzae CCUG 7484
141832	H. influenzae CCUG 7566
141835	H. influenzae CCUG 7585 A
142064	H. influenzae CCUG 10229
142494	H. influenzae CCUG 12676
142495	H. influenzae CCUG 12677
142518	H. influenzae CCUG 12769, CCUG 17780
142519	H. influenzae CCUG 12770
142557	H. influenzae CCUG 12974
142564	H. influenzae CCUG 13033
142565	H. influenzae CCUG 13045
142566	H. influenzae CCUG 13059
142568	H. influenzae CCUG 13081
142605	H. influenzae CCUG 13269
142618	H. influenzae CCUG 13336
142625	H. influenzae CCUG 13410
142774	H. influenzae CCUG 14580
142775	H. influenzae CCUG 14585
142776	H. influenzae CCUG 14586
142777	H. influenzae CCUG 14591
142833	H. influenzae CCUG 15195
142864	H. influenzae CCUG 15397
142870	H. influenzae CCUG 15435, CCUG 15515
142880	H. influenzae CCUG 15521
142896	H. influenzae CCUG 15640
142917	H. influenzae CCUG 15702
142918	H. influenzae CCUG 15703
142919	H. influenzae CCUG 15704
142920	H. influenzae CCUG 15705
142921	H. influenzae CCUG 15706
142922	H. influenzae CCUG 15707
142923	H. influenzae CCUG 15708
143049	H. influenzae CCUG 16552
143089	H. influenzae CCUG 17144
143259	H. influenzae CCUG 18095
143308	H. influenzae CCUG 18372, CCUG 7318, ATCC 9332, NCTC 8470
143380	H. influenzae CCUG 18800
143403	H. influenzae CCUG 18929 A
143404	H. influenzae CCUG 18929 B
143405	H. influenzae CCUG 18930 B
143563	H. influenzae CCUG 20156
143681	H. influenzae CCUG 20947
143702	H. influenzae CCUG 21069
143856	H. influenzae CCUG 21594
143872	H. influenzae CCUG 21678 A
143873	H. influenzae CCUG 21682
144201	H. influenzae CCUG 23552
144202	H. influenzae CCUG 23553
144209	H. influenzae CCUG 23622, MCCM 23622
144221	H. influenzae CCUG 23695
144254	H. influenzae CCUG 23969
144364	H. influenzae CCUG 24753
144365	H. influenzae CCUG 24767
144538	H. influenzae CCUG 25596
144639	H. influenzae CCUG 26001
144771	H. influenzae CCUG 26502
145347	H. influenzae CCUG 28240
145569	H. influenzae CCUG 28854
145972	H. influenzae CCUG 30048
146592	H. influenzae CCUG 31544
146938	H. influenzae CCUG 32495
147072	H. influenzae CCUG 32790
147323	H. influenzae CCUG 33366
147810	H. influenzae CCUG 34267
148062	H. influenzae CCUG 34748
148137	H. influenzae CCUG 34886
148194	H. influenzae CCUG 35019
148261	H. influenzae CCUG 35120, NCTC 10479
148315	H. influenzae CCUG 35214 A
148353	H. influenzae CCUG 35273
148421	H. influenzae CCUG 35407
148585	H. influenzae CCUG 35672
148758	H. influenzae CCUG 35906
148830	H. influenzae CCUG 36017, MCCM 02733
148831	H. influenzae CCUG 36039, MCCM 02805
149004	H. influenzae CCUG 36704
149149	H. influenzae CCUG 36943
149220	H. influenzae CCUG 37291
149314	H. influenzae CCUG 37479
149466	H. influenzae CCUG 37795
149547	H. influenzae CCUG 37942
149592	H. influenzae CCUG 38024
149663	H. influenzae CCUG 38141
150131	H. influenzae CCUG 39059
150396	H. influenzae CCUG 39823
150414	H. influenzae CCUG 39845
150571	H. influenzae CCUG 41635
150586	H. influenzae CCUG 41677
150809	H. influenzae CCUG 42409
150834	H. influenzae CCUG 42520
151358	H. influenzae CCUG 43842
151904	H. influenzae CCUG 45156
151990	H. influenzae CCUG 45442
152105	H. influenzae CCUG 45795
152376	H. influenzae CCUG 46574
152604	H. influenzae CCUG 47184
152819	H. influenzae CCUG 47707
153676	H. influenzae CCUG 50618
154203	H. influenzae CCUG 52721
154590	H. influenzae CCUG 54503
155611	H. influenzae CCUG 58365
156132	H. influenzae CCUG 60490
156564	H. influenzae CCUG 62705
156671	H. influenzae CCUG 64045
174468	H. influenzae DSM 116965, NCCP 13793
174469	H. influenzae DSM 116967, NCCP 13809
174470	H. influenzae DSM 116968, NCCP 13812
174471	H. influenzae DSM 118151, NCCP 14512
174472	H. influenzae DSM 118152, NCCP 14578
174473	H. influenzae DSM 118328, NCCP 14579
174474	H. influenzae DSM 118329, NCCP 14582

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
120111	negative	rod-shaped

Colony morphology

@ref	Incubation period
4562	1-2 days
120111

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
4562	COLUMBIA BLOOD AGAR (DSMZ Medium 429)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD AGAR (DSMZ Medium 429) Composition: Horse blood 40.0 g/l Columbia agar base
4562	HAEMOPHILUS MEDIUM (DSMZ Medium 804)	Medium recipe at MediaDive	Name: HAEMOPHILUS MEDIUM (DSMZ Medium 804) Composition: Mueller-Hinton broth 21.0 g/l Yeast extract 5.0 g/l Distilled water
41776	MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml);PolyVitex mischung (10.000 ml)
120111	CIP Medium 10	Medium recipe at CIP
120111	CIP Medium 10_BIORAD	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
4562	positive	growth	37
41776	positive	growth	37
120111	positive	growth	37
120111	negative	growth	30
120111	negative	growth	41

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
4562	microaerophile
120111	facultative anaerobe

Antibiotic susceptibility testing

	Test 1	Test 2	Test 3	Test 4	Test 5	Test 6	Test 7
@ref	4562	4562	4562	4562	4562	4562	4562
Medium	M 804	M 804	M 804	M 804	M 804	M 804	M 804
Manual annotation	1	1	1	1	1	1	1
	Inhibition zone diameter in mm	Inhibition zone diameter in mm	Inhibition zone diameter in mm	Inhibition zone diameter in mm	Inhibition zone diameter in mm	Inhibition zone diameter in mm	Inhibition zone diameter in mm
Amikacin 30µg (disc)	24	26	24-26	20	20	16-18	22
Ampicillin 10µg (disc)	32-34	32	30-32	26-28	26-28	28	32
Aztreonam 30µg (disc)	40-42	42	40	38-40	38-40	36	42
Bacitracin 10Unit	6	0	0	0	0	0	n.d.
Cefalotin 30µg (disc)	32	32	32	30	30	28	n.d.
Cefazolin 30µg (disc)	30	28	30	22-24	22-24	20	n.d.
Cefiderocol 30µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	30
Cefotaxime 30µg (disc)	44	44-46	42-44	40	40	40	42-44
Ceftazidime 10µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	34
Ceftriaxone 30µg (disc)	44	44	46-48	40-42	40-42	38-40	46
Chloramphenicol 30µg (disc)	40	40-42	40	34-36	34-36	36	38-40
Ciprofloxacin 5µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	42-44
Clindamycin 10µg (disc)	20	18-20	16	16	16	10-12	6-8
Colistin 10µg (disc)	20	20	20-22	18	18	16	n.d.
Colistin sulphate 10µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	20
Doxycycline 30µg (disc)	30	32	32	24	24	20	n.d.
Erythromycin 15µg (disc)	14	18-20	14-16	12	12	12	16
Fosfomycin 50µg (disc)	>50	>50	>50	46-48	46-48	44	48-50
Gentamicin 30µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	24-26
Gentamycin 10µg (disc)							n.d.
Imipenem 10µg (disc)	32	30	32	28	28	24	32
Kanamycin 30µg (disc)	26-28	30	24-26	22	22	18-20	24-26
Levofloxacin 5µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	40
Lincomycin 15µg (disc)	14-16	18	14-16	10	10	0	n.d.
Linezolid 10µg (disc)	24	24	18	18	18	14-16	24
Meropenem 10µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	38-40
Mezlocillin 30µg (disc)	40-42	40	40	34	34	32	n.d.
Moxifloxacin 5µg (disc)	34-36	38	34-36	30-32	30-32	30	40
Neomycin 30µg (disc)	18	22	20	16-18	16-18	12-14	n.d.
Nitrofurantoin 100µg (disc)	38	34-36	40-42	26	26	24-26	30
Norfloxacin 10µg (disc)	32-34	40	34-36	32	32	32	n.d.
Nystatin 100Unit	0	0	12	0	0	0	n.d.
Ofloxacin 5µg (disc)	34-36	40	34	32-34	32-34	32	40
Oxacillin 5µg (disc)	8	6	10	8	8	6	0
Penicillin G 6µg (disc)	30-32	30	30	28	28	26	32
Pipemidic acid 20µg (disc)	24	24	26	20-22	20-22	20	n.d.
Piperacillin/Tazobactam 40µg (disc)	42	44	40-42	36	36	32-34	n.d.
Piperacillin/Tazobactam 110µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	48
Polymyxin B 300Unit	20	20	20	16	16	18	20
Quinupristin/Dalfopristin 15µg (disc)	18	20-22	18-20	14-16	14-16	14	n.d.
Rifampicin 5µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	22-24
Teicoplanin 30µg (disc)	6	6	0	6-8	6-8	6	8
Tetracycline 30µg (disc)	34-36	38	36-38	28-30	28-30	26-28	32
Ticarcillin 75µg (disc)	40	42-44	40	38	38	36	42
Tigecycline 15µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	28-30
Trimethoprim-sulfamethoxazole (1:19) 10µg (disc)	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	0
Vancomycin 30µg (disc)	8	10	0	0	0	0	6

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68377	17634 ChEBI	D-glucose	+	builds acid from	from API NH
120111	17632 ChEBI	nitrate	+	reduction
120111	16301 ChEBI	nitrite	-	reduction
68377	18257 ChEBI	ornithine	-	degradation	from API NH
68377	27897 ChEBI	tryptophan	+	energy source	from API NH
68377	16199 ChEBI	urea	+	hydrolysis	from API NH

Antibiotic resistance

@ref	Metabolite	Is resistant	Resistance conc.
4562	Trimethoprim-sulfamethoxazole (1:19)		10 µg (disc)	from Antibiotic test

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68377	35581 ChEBI	indole		from API NH
120111	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68377	35581 ChEBI	indole	+	from API NH

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
120111	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68377	alkaline phosphatase	+	3.1.3.1	from API NH
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	-	3.2.1.23	from API zym
120111	beta-galactosidase	-	3.2.1.23
68377	beta-galactosidase	-	3.2.1.23	from API NH
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68377	beta-lactamase	-	3.5.2.6	from API NH
4562	catalase	+	1.11.1.6
120111	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
4562	cytochrome-c oxidase	+	1.9.3.1
68382	leucine arylamidase	+	3.4.11.1	from API zym
68377	lipase	-		from API NH
68382	lipase (C 14)	-		from API zym
120111	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
120111	ornithine decarboxylase	-	4.1.1.17
68377	ornithine decarboxylase	-	4.1.1.17	from API NH
120111	oxidase	-
68377	proline-arylamidase	-	3.4.11.5	from API NH
68382	trypsin	-	3.4.21.4	from API zym
120111	tryptophan deaminase	-
68377	tryptophan deaminase	+	4.1.99.1	from API NH
120111	urease	+	3.5.1.5
68377	urease	+	3.5.1.5	from API NH
68382	valine arylamidase	-		from API zym

Fatty acid profile

Metadata FA analysis

@ref

49650

Fatty acid	Percentage	ECL
C16:1 ω7c	37	15.819
C16:0	32	16
C14:0	19.3	14
C14:0 3OH/C16:1 ISO I	7.4	15.485
C18:0	1	18
C18:2 ω6,9c/C18:0 ANTE	0.7	17.724
C16:1 ω7c DMA	0.4	16.288
C15:0 ISO 3OH	0.4	16.135
unknown 14.503	0.4	14.503
C13:0 ISO 2OH	0.4	13.814
C18:1 ω7c /12t/9t	0.3	17.824
C16:1 ω5c	0.2	15.908
C12:0	0.2	12
C18:1 ω9c	0.1	17.769

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
49650	-	+	-	-	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-
120111	-	+	+	+	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-

API NH

@ref	PEN	GLU	FRU	MAL	SAC	ODC	URE	LIP	PAL	beta GAL	ProA	GGT	IND
4562	-	+	+	-	-	-	+	-	+	-	-	+	+
49650	-	+	+	-	-	-	+	-	+	-	-	-	+
49650	-	+	-	-	-	-	+	-	+	-	-	-	+
4562	-	+	+	-	-	-	+	-	+	-	-	-	+
4562	-	+	+	-	+	-	+	-	+	-	-	+	+
4562	-	+	+	+/-	+/-	-	+	-	+	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host Body-Site	#Oral cavity and airways	#Lung
#Host Body-Site	#Other	#Abscess

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent	Isolation date
4562	lung abcess	USA	USA	North America
49650	Human lung abscess,57-year-old patient
120111		United States of America	USA	North America	1986

Taxonmaps

69479

Global distribution of 16S sequence HE978269 (>99% sequence identity) for Haemophilus influenzae from Microbeatlas

Aquatic Samples	597
Soil Samples	173
Animal Samples	30711
Plant Samples	55
Total Samples	31536

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
4562	2	Risk group (German classification) According to TRBA 466
120111	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	NCBI tax ID	Score
124043	47555_F02 assembly for Haemophilus influenzae NCTC12975	complete	GCA_900475995	727.1601	727	99.56

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
4562	Haemophilus influenzae partial 16S rRNA gene, strain DSM 11970	HE978269	1532		727

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Rapid high-throughput processing of tissue samples for microbiological diagnosis of periprosthetic joint infections using bead-beating homogenization.	Jazmati N, Liebold C, Offerhaus C, Volkenand A, Grote S, Popsel J, Korber-Irrgang B, Hoppe T, Wisplinghoff H.	J Clin Microbiol	10.1128/jcm.01486-23	2024
	Characteristics of 241 invasive and non-invasive Haemophilus influenzae isolated from patients under 14 years old, Hebei Province, China.	Che J, Zhang HB, Guo YH, Jia ZY, He BH, Chen BH, Shao ZJ, Sun YQ, Li Q.	BMC Infect Dis	10.1186/s12879-025-11396-2	2025
	In vitro antimicrobial activity of an oral spray combining 0.15% benzydamine hydrochloride and 0.5% cetylpyridinium chloride.	de Joannon AC, Eggers M, Boltri L.	Drugs Context	10.7573/dic.2024-9-3	2025
	The lack of specificity of sodC-based PCR for the detection of Neisseria meningitidis carriage in pharyngeal swabs from adolescents.	Pham-Tran DD, Leong LEX, McMillan M, Lawrence A, Mohammed H, Finn A, Marshall HS.	Microbiol Spectr	10.1128/spectrum.02779-24	2025
	Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to beta-lactams.	Jakubu V, Cechova M, Musilek M, Malisova L, Zapletalova B, Zemlickova H.	J Antimicrob Chemother	10.1093/jac/dkaf023	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Pakistan: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Nizamuddin S, Morrissey I, Manenzhe R, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf288	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Bratus E, Yuvko O, Pertseva T, Morrissey I, Beltrame CO, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf287	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in India: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Veeraraghavan B, Patil N, Dias M, Maheshwari G, Chaudhuri BN, Ray U, Hawser S, Kundu S, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf285	2025
	Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones	Skaare D, Anthonisen I, Zecic N, Jenkins A, Caugant D, Ranheim T, Sundsfjord A, Hegstad K.	Front Microbiol		2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Tunisia: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Slim L, Hammami A, Hawser S, Manenzhe R, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf286	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2020-21 in Vietnam: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Van PH, Thinh LQ, Hawser S, Kundu S, Truong Ha Lan N, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf290	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Türkiye: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Keles N, Hasdemir U, Hazirolan G, Aydemir S, Aktas Z, Oncul O, Morrissey I, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf289	2025
	Microbial Composition, Antibiotic Sensitivity Patterns, and Contributing Factors Among Children With Tonsillitis in Hawassa Town, Sidama, Ethiopia.	Tirago TD, Worku M, Nima TM, Ormago MD.	Int J Microbiol	10.1155/ijm/6366378	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Italy and Spain: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Canton R, Pitart C, Sanguinetti M, Vismara C, Farina C, Sambri V, Hawser S, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf283	2025
	Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Kuwait and the United Arab Emirates: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.	Torumkuney D, Mokaddas E, Weber S, Morrissey I, Keles N, Manoharan A.	J Antimicrob Chemother	10.1093/jac/dkaf284	2025
	Typeable ampicillin-resistant Haemophilus influenzae strains in Tunisian's children.	Mzilem S, Boukhchina S.	Medicine (Baltimore)	10.1097/md.0000000000030713	2022
	Chronic infection by nontypeable Haemophilus influenzae fuels airway inflammation.	Saliu F, Rizzo G, Bragonzi A, Cariani L, Cirillo DM, Colombo C, Dacco V, Girelli D, Rizzetto S, Sipione B, Cigana C, Lore NI.	ERJ Open Res	10.1183/23120541.00614-2020	2021
Enzymology	Early detection of drug-resistant Streptococcus pneumoniae and Haemophilus influenzae by quantitative flow cytometry.	Sawada T, Katayama M, Takatani S, Ohiro Y.	Sci Rep	10.1038/s41598-021-82186-4	2021
	Antibacterial, Antioxidant Potency, and Chemical Composition of Essential Oils from Dried Powdered Leaves and Flowers of Hypericum revolutum subsp. keniense (Schweinf.).	Sengera GO, Kenanda EO, Onyancha JM.	Evid Based Complement Alternat Med	10.1155/2023/4125885	2023
	Evaluation of advanced platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam.	Straub A, Vollmer A, Lam TT, Brands RC, Stapf M, Scherf-Clavel O, Bittrich M, Fuchs A, Kubler AC, Hartmann S.	Clin Oral Investig	10.1007/s00784-022-04663-y	2022
	Robust and low-cost open-source device for detecting infectious microorganisms by loop-mediated isothermal amplification.	Otero J, Rodriguez-Lazaro MA, Martinez-Trejo A, Mbanze D, Solana G, Vergara A, Bosch S, Gozal D, Vila J, Farre R.	HardwareX	10.1016/j.ohx.2024.e00568	2024
Phylogeny	Case Report: The First Report on Moraxella canis Isolation From Corneal Ulcer in a Bulldog.	Wang Z, Guo L, Li J, Li J, Cui L, Dong J, Wang H.	Front Vet Sci	10.3389/fvets.2022.934081	2022
	Environmental innovation: polyaniline-cuttlebone nanocomposite as a potent antimicrobial agent and a synergistic barrier against doxorubicin-induced toxicity.	Salama E, Abo El-Ela FI, Hassan WH, Farghali AA, Eweis AA, Hafez SHM, Mahmoud R.	RSC Adv	10.1039/d4ra07471h	2025
	Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial.	Straub A, Utz C, Stapf M, Vollmer A, Kasper S, Kubler AC, Brands RC, Hartmann S, Lam TT.	Clin Oral Investig	10.1007/s00784-023-05212-x	2023
	Prevalence of susceptibility patterns of opportunistic bacteria in line with CLSI or EUCAST among Haemophilus parainfluenzae isolated from respiratory microbiota.	Kosikowska U, Andrzejczuk S, Grywalska E, Chwiejczak E, Winiarczyk S, Pietras-Ozga D, Stepien-Pysniak D.	Sci Rep	10.1038/s41598-020-68161-5	2020
	Antibacterial Activity of Thesium chinense Turcz Extract Against Bacteria Associated with Upper Respiratory Tract Infections.	Wei J, Zhang C, Ma W, Ma J, Liu Z, Ren F, Li N.	Infect Drug Resist	10.2147/idr.s425398	2023
	Promoting molecular diagnostic equity: assessing in-house real-time PCR for Neisseria gonorrhoeae in anal samples from MSM recruited in an outpatient setting in Morocco.	Aitlhaj-Mhand R, Qasmaoui A, Bellaji B, Remz C, Charof R, Jaoudi RE, Abdelmoumen H, Hancali A, Oumzil H.	Infez Med	10.53854/liim-3203-9	2024
	Effect of Haemophilus influenzae Type b Vaccination on Nasopharyngeal Carriage Rate in Children, Tehran, 2019.	Tabatabaei SR, Mohammadzadeh S, Zahraei SM, Mahmoudi S, Ghandchi G, Hoseini-Alfatemi SM, Karimi A, Shamshiri A.	Biomed Res Int	10.1155/2021/4923852	2021
	Characterization of Haemophilus influenzae Strains with Non-Enzymatic Resistance to beta-Lactam Antibiotics Caused by Mutations in the PBP3 Gene in the Czech Republic in 2010-2018.	Jakubu V, Malisova L, Musilek M, Pomorska K, Zemlickova H.	Life (Basel)	10.3390/life11111260	2021
	Comparison of the Distribution and Changes in the Antibiotic Resistance of Clinical Bacterial Isolates from the Lower Respiratory Tract of Children in Shenzhen Before the Epidemic, During the Epidemic, and During the Period of Normalized Prevention and Control of COVID-19.	Meng Q, Li W, Jiang H, Yan H, Wang H, Ye B, Zhou L, Chen Y.	Infect Dis Ther	10.1007/s40121-022-00751-4	2023
	Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae in the United States in 2016.	Potts CC, Rodriguez-Rivera LD, Retchless AC, Buono SA, Chen AT, Marjuki H, Blain AE, Wang X.	Microbiol Spectr	10.1128/spectrum.02579-21	2022
	In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of Haemophilus haemolyticus.	Atto B, Latham R, Kunde D, Gell DA, Tristram S.	Pathogens	10.3390/pathogens9040243	2020
	Co-infection with dual Streptococcus pneumoniae serotypes as a cause of pediatric bacterial meningitis in Iran: a multi-center cross-sectional study.	Tabatabaei SR, Shamshiri A, Azimi L, Nazari-Alam A, Karimi A, Mirjavadi SA, Tariverdi M.	BMC Infect Dis	10.1186/s12879-022-07606-w	2022
	Immunization with Protein D from Non-Typeable Haemophilus influenzae (NTHi) Induced Cytokine Responses and Bioactive Antibody Production.	Davoudi Vijeh Motlagh A, Siadat SD, Abedian Kenari S, Mahdavi M, Behrouzi A, Asgarian-Omran H.	Jundishapur J Microbiol	10.5812/jjm.36617	2016
	A Laboratory-Based Surveillance Study of Invasive Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae Diseases in a Serbian Pediatric Population-Implications for Vaccination.	Delic S, Mijac V, Gajic I, Kekic D, Ranin L, Jegorovic B, Culic D, Cirkovic V, Siljic M, Stanojevic M, Paragi M, Markovic M, Opavski N.	Diagnostics (Basel)	10.3390/diagnostics11061059	2021
	Molecular Epidemiology and Antimicrobial Resistance of Haemophilus influenzae in Adult Patients in Shanghai, China.	Li XX, Xiao SZ, Gu FF, He WP, Ni YX, Han LZ.	Front Public Health	10.3389/fpubh.2020.00095	2020
Pathogenicity	Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens.	Gilpin DF, McGown KA, Gallagher K, Bengoechea J, Dumigan A, Einarsson G, Elborn JS, Tunney MM.	Respir Res	10.1186/s12931-019-1206-8	2019
	Distribution and Antimicrobial Susceptibility Profiles of Pathogens in Patients With Esophageal Cancer From 2013 to 2022: A Retrospective Study.	Meng H, Wang Y, Li Z, Yan J, Yu W, Chen C.	Health Sci Rep	10.1002/hsr2.70214	2024
	Loureirin A is a narrow-spectrum antimicrobial agent against Helicobacter pylori.	Tong Q, Yin C, Hang X, Bai Y, Zhang C, Xu J, Huang Y, Ge Y, Chen T, Zeng L, Jia J, Bi H.	Antimicrob Agents Chemother	10.1128/aac.00314-24	2024
Genetics	Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans.	Granlund M, Aberg CH, Johansson A, Claesson R.	Antibiotics (Basel)	10.3390/antibiotics11030317	2022
	Texture-based speciation of otitis media-related bacterial biofilms from optical coherence tomography images using supervised classification.	Zaki FR, Monroy GL, Shi J, Sudhir K, Boppart SA.	J Biophotonics	10.1002/jbio.202400075	2024
	Thermostable Heptaplex PCR Assay for the Detection of Six Respiratory Bacterial Pathogens.	Nik Zuraina NMN, Goni MD, Amalina KN, Hasan H, Mohamad S, Suraiya S.	Diagnostics (Basel)	10.3390/diagnostics11050753	2021
Pathogenicity	Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion.	Kitaoka K, Kimura K, Kitanaka H, Banno H, Jin W, Wachino JI, Arakawa Y.	Antimicrob Agents Chemother	10.1128/aac.00671-18	2018
	Validation of Three MicroScan^® Antimicrobial Susceptibility Testing Plates Designed for Low-Resource Settings.	Ronat JB, Oueslati S, Natale A, Kesteman T, Elamin W, Langendorf C, Hardy L, Vandenberg O, Naas T.	Diagnostics (Basel)	10.3390/diagnostics12092106	2022
	Comparison of the New VITEK MS PRIME System with the Matrix-Assisted Laser Desorption Ionization Biotyper Microflex LT for the Identification of Microorganisms.	Grohs P, Remaud E, Lath C, Vuong K, Parolini ML, Dannaoui E, Podglajen I.	Ann Lab Med	10.3343/alm.2023.43.6.574	2023
	Unexpected clinical case of Pasteurella multocida infectious endocarditis in a patient with iv drug abuse: why epidemiological history matters.	Rachina SA, Mukhina NV, Cherkasova NA, Komarova IS, Ushakova OE, Nasrulloeva SM, Burmistrova EN, Ivanchik NV.	Germs	10.18683/germs.2022.1316	2022
	Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms.	Padalino G, Duggan K, Mur LAJ, Maillard JY, Brancale A, Hoffmann KF.	Microbiologyopen	10.1002/mbo3.70011	2024
	Time to switch from CLSI to EUCAST? A Southeast Asian perspective.	Cusack TP, Ashley EA, Ling CL, Roberts T, Turner P, Wangrangsimakul T, Dance DAB.	Clin Microbiol Infect	10.1016/j.cmi.2019.03.016	2019
Metabolism	Cell vacuolation induced by Haemophilus influenzae supernatants in HEp-2 cells.	Espinoza-Mellado Mdel R, Lopez-Villegas EO, Arteaga-Garibay RI, Giono-Cerezo S.	Mem Inst Oswaldo Cruz	10.1590/0074-0276130716	2013
	Differentiation of otitis media-causing bacteria and biofilms via Raman spectroscopy and optical coherence tomography.	Locke AK, Zaki FR, Fitzgerald ST, Sudhir K, Monroy GL, Choi H, Won J, Mahadevan-Jansen A, Boppart SA.	Front Cell Infect Microbiol	10.3389/fcimb.2022.869761	2022
	Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin-Triazole-Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors.	Dimkovski A, Dobricic V, Simic MR, Jurhar Pavlova M, Mihajloska E, Sterjev Z, Poceva Panovska A.	Molecules	10.3390/molecules30102121	2025
	Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC) during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae.	Cherkaoui A, Diene SM, Fischer A, Leo S, Francois P, Schrenzel J.	Front Microbiol	10.3389/fmicb.2017.02676	2017
Pathogenicity	Reduced levofloxacin susceptibility in clinical respiratory isolates of Haemophilus influenzae is not yet associated with mutations in the DNA gyrase and topoisomerase II genes in Korea.	Kim IS, Lee NY, Kim S, Ki CS, Kim SH.	Yonsei Med J	10.3349/ymj.2011.52.1.188	2011
	Antimicrobial Susceptibility Testing for Staphylococcus lugdunensis.	Teh JSK, Pantelis I, Chen X, Sadlon T, Papanaoum K, Gordon DL.	J Clin Microbiol	10.1128/jcm.03202-20	2022
	In Vitro Activity of MRX-8 and Comparators Against Clinical Isolated Gram-Negative Bacilli in China.	Wu S, Yin D, Zhi P, Guo Y, Yang Y, Zhu D, Hu F.	Front Cell Infect Microbiol	10.3389/fcimb.2022.829592	2022
Enzymology	In vitro activities of Eravacycline against 336 isolates collected from 2012 to 2016 from 11 teaching hospitals in China.	Zhao C, Wang X, Zhang Y, Wang R, Wang Q, Li H, Wang H.	BMC Infect Dis	10.1186/s12879-019-4093-1	2019
Enzymology	2-oxoglutarate:acceptor oxidoreductase-catalyzed redox cycling effectively targets coccoid forms of Helicobacter pylori.	Hang X, Lan W, Yanqiang H, Huang H, Zhang M, Zeng L, Shi T, Bai Y, Yang Z, Hu S, Wang J, Dong L, Tong Q, Jia J, Bi S, Xia Q, Gao Y, Bi H.	Nat Commun	10.1038/s41467-025-62477-4	2025
	Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens.	Dobay O, Laub K, Stercz B, Keri A, Balazs B, Tothpal A, Kardos S, Jaikumpun P, Ruksakiet K, Quinton PM, Zsembery A.	Front Microbiol	10.3389/fmicb.2018.02245	2018
Enzymology	Identification and Characterization of "Haemophilus quentini" Strains Causing Invasive Disease in Ontario, Canada (2016 to 2018).	Kus JV, Shuel M, Soares D, Hoang W, Law D, Tsang RSW.	J Clin Microbiol	10.1128/jcm.01254-19	2019
Genetics	Genotyping of Haemophilus influenzae type b strains and their incidence in the clinical samples isolated from Iranian patients.	Bagherzadeh Khodashahri S, Siadat SD, Rahbar M, Abdollahpour-Alitappeh M, Vaziri F, Rahnamaye-Farzami M, Mohammadzadeh M, Davari M, Fateh A, Masoumi M.	Iran J Microbiol		2015
	The preparation and clinical application of diagnostic DNA microarray for the detection of pathogens in intracranial bacterial and fungal infections.	Cao J, Gao S, Chen J, Zhu B, Min R, Wang P.	Exp Ther Med	10.3892/etm.2018.6312	2018
Pathogenicity	A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid Produces a Reversible Increase in Antibiotic Resistance.	Santos-Lopez A, Bernabe-Balas C, Ares-Arroyo M, Ortega-Huedo R, Hoefer A, San Millan A, Gonzalez-Zorn B.	Antimicrob Agents Chemother	10.1128/aac.01735-16	2017
	Designing novel construction for cell surface display of protein E on Escherichia coli using non-classical pathway based on Lpp-OmpA.	Jeiranikhameneh M, Razavi MR, Irani S, Siadat SD, Oloomi M.	AMB Express	10.1186/s13568-017-0350-0	2017
Enzymology	Characterization of nasopharyngeal isolates of type b Haemophilus influenzae from Delhi.	Saikia KK, Das BK, Bewal RK, Kapil A, Arora NK, Sood S.	Indian J Med Res		2012
Pathogenicity	In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori.	Huang Y, Hang X, Jiang X, Zeng L, Jia J, Xie Y, Li F, Bi H.	Antimicrob Agents Chemother	10.1128/aac.00004-19	2019
	Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo.	Luo P, Huang Y, Hang X, Tong Q, Zeng L, Jia J, Zhang G, Bi H.	Antimicrob Agents Chemother	10.1128/aac.01921-20	2021
Pathogenicity	Antibiotic susceptibility in Streptococcus pneumoniae, Haemophilus influenzae and Streptococcus pyogenes in Pakistan: a review of results from the Survey of Antibiotic Resistance (SOAR) 2002-15.	Zafar A, Hasan R, Nizamuddin S, Mahmood N, Mukhtar S, Ali F, Morrissey I, Barker K, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw076	2016
Phylogeny	Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae.	Skaare D, Anthonisen IL, Caugant DA, Jenkins A, Steinbakk M, Strand L, Sundsfjord A, Tveten Y, Kristiansen BE.	BMC Microbiol	10.1186/1471-2180-14-131	2014
	The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance.	Kowalska-Krochmal B, Dudek-Wicher R.	Pathogens	10.3390/pathogens10020165	2021
Pathogenicity	Nasopharyngeal carriage and antimicrobial susceptibility of Haemophilus influenzae among children younger than 5 years of age in Beijing, China.	Zhu H, Wang A, Tong J, Yuan L, Gao W, Shi W, Yu S, Yao K, Yang Y.	BMC Microbiol	10.1186/s12866-015-0350-7	2015
	Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis-A Review.	Badalamenti N, Sottile F, Bruno M.	Plants (Basel)	10.3390/plants11040519	2022
Pathogenicity	Haemophilus influenzae with Non-Beta-Lactamase-Mediated Beta-Lactam Resistance: Easy To Find but Hard To Categorize.	Skaare D, Lia A, Hannisdal A, Tveten Y, Matuschek E, Kahlmeter G, Kristiansen BE.	J Clin Microbiol	10.1128/jcm.01630-15	2015
Pathogenicity	Identification of Chemical Compounds That Inhibit Protein Synthesis in Pseudomonas aeruginosa.	Palmer SO, Hu Y, Keniry M, Bullard JM.	SLAS Discov	10.1177/1087057116679591	2017
	Osteoarticular Infection in Three Young Thoroughbred Horses Caused by a Novel Gram Negative Cocco-Bacillus.	Hudson BJ, Chicken C, Blishen A, Todhunter KH, Begg AP, Chan L, Karagiannis T, Raymond B, Bogema D, Adkins AR, O'Sullivan CB, O'Rourke BA, Roy Chowdhury P, Djordjevic SP, Charles IG, Edgar A, Mitsakos K.	Case Rep Vet Med	10.1155/2020/9785861	2020
	Performance Evaluation of the SAMBA II SARS-CoV-2 Test for Point-of-Care Detection of SARS-CoV-2.	Assennato SM, Ritchie AV, Nadala C, Goel N, Tie C, Nadala LM, Zhang H, Datir R, Gupta RK, Curran MD, Lee HH.	J Clin Microbiol	10.1128/jcm.01262-20	2020
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2002-09 in Turkey.	Torumkuney D, Gur D, Soyletir G, Gurler N, Aktas Z, Sener B, Tunger A, Bayramoglu G, Koksal I, Yalcin AN, Tanriver Y, Morrissey I, Barker K.	J Antimicrob Chemother	10.1093/jac/dkw067	2016
Pathogenicity	Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria.	Asli A, Brouillette E, Krause KM, Nichols WW, Malouin F.	Antimicrob Agents Chemother	10.1128/aac.02102-15	2016
Pathogenicity	Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.	D'Atanasio N, Capezzone de Joannon A, Di Sante L, Mangano G, Ombrato R, Vitiello M, Bartella C, Magaro G, Prati F, Milanese C, Vignaroli C, Di Giorgio FP, Tongiani S.	PLoS One	10.1371/journal.pone.0228509	2020
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in Ukraine.	Feshchenko Y, Dzyublik A, Pertseva T, Bratus E, Dzyublik Y, Gladka G, Morrissey I, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw068	2016
Enzymology	Development of two real-time multiplex PCR assays for the detection and quantification of eight key bacterial pathogens in lower respiratory tract infections.	Gadsby NJ, McHugh MP, Russell CD, Mark H, Conway Morris A, Laurenson IF, Hill AT, Templeton KE.	Clin Microbiol Infect	10.1016/j.cmi.2015.05.004	2015
	Characterization of bacteria causing acute otitis media using Raman microspectroscopy.	Ayala OD, Wakeman CA, Pence IJ, O'Brien CM, Werkhaven JA, Skaar EP, Mahadevan-Jansen A.	Anal Methods	10.1039/c7ay00128b	2017
Pathogenicity	Regional and global antimicrobial susceptibility among isolates of Streptococcus pneumoniae and Haemophilus influenzae collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) from 2009 to 2012 and comparison with previous years of T.E.S.T. (2004-2008).	Tomic V, Dowzicky MJ.	Ann Clin Microbiol Antimicrob	10.1186/s12941-014-0052-2	2014
Pathogenicity	Discovery and Characterization of Chemical Compounds That Inhibit the Function of Aspartyl-tRNA Synthetase from Pseudomonas aeruginosa.	Corona A, Palmer SO, Zamacona R, Mendez B, Dean FB, Bullard JM.	SLAS Discov	10.1177/2472555217744559	2018
	Identification and Characterization of a Chemical Compound that Inhibits Methionyl-tRNA Synthetase from Pseudomonas aeruginosa.	Robles S, Hu Y, Resto T, Dean F, Bullard JM.	Curr Drug Discov Technol	10.2174/1570163814666170330100238	2017
Pathogenicity	Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae.	Pankuch GA, Hoellman D, Bryskier A, Lowther J, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.00587-06	2006
	Evaluation of the Biotoxis qPCR Detection Kit for Francisella tularensis Detection in Clinical and Environmental Samples.	Hennebique A, Gas F, Batina H, De Araujo C, Bizet K, Maurin M.	J Clin Microbiol	10.1128/jcm.01434-20	2020
Pathogenicity	"Affect of anaerobiosis on the antibiotic susceptibility of H. influenzae".	Smith HK, Nelson KL, Calaunan ES, Smith AL, Nguyen V.	BMC Res Notes	10.1186/1756-0500-6-241	2013
Enzymology	Biofilm formation by Haemophilus influenzae isolated from adeno-tonsil tissue samples, and its role in recurrent adenotonsillitis.	Galli J, Calo L, Ardito F, Imperiali M, Bassotti E, Fadda G, Paludetti G.	Acta Otorhinolaryngol Ital		2007
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2009-11 in Vietnam.	Van PH, Binh PT, Minh NH, Morrissey I, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw069	2016
Genetics	Species Identification and Antibiotic Resistance Prediction by Analysis of Whole-Genome Sequence Data by Use of ARESdb: an Analysis of Isolates from the Unyvero Lower Respiratory Tract Infection Trial.	Ferreira I, Beisken S, Lueftinger L, Weinmaier T, Klein M, Bacher J, Patel R, von Haeseler A, Posch AE.	J Clin Microbiol	10.1128/jcm.00273-20	2020
	Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitness.	San Millan A, Santos-Lopez A, Ortega-Huedo R, Bernabe-Balas C, Kennedy SP, Gonzalez-Zorn B.	Antimicrob Agents Chemother	10.1128/aac.00235-15	2015
Pathogenicity	Molecular epidemiology of ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae.	Gazagne L, Delmas C, Bingen E, Dabernat H.	J Clin Microbiol	10.1128/jcm.36.12.3629-3635.1998	1998
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2009-11 and 2013-14 in China.	Hu F, Zhu D, Wang F, Morrissey I, Wang J, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw065	2016
Pathogenicity	Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method.	Garcia-Cobos S, Campos J, Roman F, Carrera C, Perez-Vazquez M, Aracil B, Oteo J.	Antimicrob Agents Chemother	10.1128/aac.00214-08	2008
Enzymology	Molecular detection of human parechovirus in under-Five-Year-Old Children with gastroenteritis.	Bergallo M, Galliano I, Montanari P, Rosa Brusin M, Gabiano C.	J Clin Virol	10.1016/j.jcv.2016.10.001	2016
Enzymology	Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination.	San Millan A, Garcia-Cobos S, Escudero JA, Hidalgo L, Gutierrez B, Carrilero L, Campos J, Gonzalez-Zorn B.	Antimicrob Agents Chemother	10.1128/aac.01489-09	2010
Pathogenicity	Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States.	Heilmann KP, Rice CL, Miller AL, Miller NJ, Beekmann SE, Pfaller MA, Richter SS, Doern GV.	Antimicrob Agents Chemother	10.1128/aac.49.6.2561-2564.2005	2005
	Direct molecular detection of amoxicillin-susceptible E. coli in urine samples from children with suspected urinary tract infection: A potential tool to improve antibiotic stewardship and patient care.	Slinger R, Dewpura T, Verma N, Bowes J, Barrowman N, Toye B.	J Assoc Med Microbiol Infect Dis Can	10.3138/jammi.2019-0001	2019
Pathogenicity	Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance.	Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, Kang Y.	Antimicrob Agents Chemother	10.1128/aac.00966-09	2010
Pathogenicity	Global assessment of antimicrobial susceptibility among Gram-negative organisms collected from pediatric patients between 2004 and 2012: results from the Tigecycline Evaluation and Surveillance Trial.	Kehl SC, Dowzicky MJ.	J Clin Microbiol	10.1128/jcm.03184-14	2015
Metabolism	Identification of beta-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae with four methods and eight media.	Barry AL, Fuchs PC, Brown SD.	Antimicrob Agents Chemother	10.1128/aac.45.5.1585-1588.2001	2001
Pathogenicity	Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong.	Ho PL, Chow KH, Mak GC, Tsang KW, Lau YL, Ho AY, Lai EL, Chiu SS.	Emerg Infect Dis	10.3201/eid1011.040055	2004
	Detection of respiratory viruses and bacteria in children using a twenty-two target reverse-transcription real-time PCR (RT-qPCR) panel.	Ellis C, Misir A, Hui C, Jabbour M, Barrowman N, Langill J, Bowes J, Slinger R.	World J Pediatr	10.1007/s12519-015-0069-4	2016
	Quality control guidelines for BAL9141 (Ro 63-9141), an investigational cephalosporin, when reference MIC and standardized disk diffusion susceptibility test methods are used.	Anderegg TR, Jones RN, Sader HS, Quality Control Working Group.	J Clin Microbiol	10.1128/jcm.42.7.3356-3358.2004	2004
Pathogenicity	Activities of HMR 3787 and RU 64399 compared with those of four other agents against Haemophilus influenzae and Haemophilus parainfluenzae.	Bozdogan B, Clark C, Bryskier A, Jacobs MR, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.47.1.405-407.2003	2003
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2011-14 in the Democratic Republic of Congo, Ivory Coast, Republic of Senegal and Kenya.	Kacou-Ndouba A, Revathi G, Mwathi P, Seck A, Diop A, Kabedi-Bajani MJ, Mwiti W, Anguibi-Pokou MJ, Morrissey I, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw070	2016
Pathogenicity	Discovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa.	Hu Y, Keniry M, Palmer SO, Bullard JM.	Antimicrob Agents Chemother	10.1128/aac.00800-16	2016
Pathogenicity	Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions.	Hirakata Y, Ohmori K, Mikuriya M, Saika T, Matsuzaki K, Hasegawa M, Hatta M, Yamamoto N, Kunishima H, Yano H, Kitagawa M, Arai K, Kawakami K, Kobayashi I, Jones RN, Kohno S, Yamaguchi K, Kaku M.	Antimicrob Agents Chemother	10.1128/aac.00192-09	2009
Enzymology	Lysyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization and Identification of Inhibitory Compounds.	Balboa S, Hu Y, Dean FB, Bullard JM.	SLAS Discov	10.1177/2472555219873095	2020
Pathogenicity	Identification and Characterization of Chemical Compounds that Inhibit Leucyl-tRNA Synthetase from Pseudomonas aeruginosa.	Zamacona R, Chavero PN, Medellin E, Hu Y, Hughes CA, Quach N, Keniry M, Bullard JM.	Curr Drug Discov Technol	10.2174/1570163815666180808095600	2020
Pathogenicity	Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism.	Wu S, Li X, Gunawardana M, Maguire K, Guerrero-Given D, Schaudinn C, Wang C, Baum MM, Webster P.	PLoS One	10.1371/journal.pone.0099204	2014
Pathogenicity	Antimicrobial susceptibilities of 1,730 Haemophilus influenzae respiratory tract isolates in Spain in 1998-1999.	Marco F, Garcia-de-Lomas J, Garcia-Rey C, Bouza E, Aguilar L, Fernandez-Mazarrasa C, Spanish Surveillance Group for Respiratory Pathogens.	Antimicrob Agents Chemother	10.1128/aac.45.11.3226-3228.2001	2001
	Development of a broad-range 23S rDNA real-time PCR assay for the detection and quantification of pathogenic bacteria in human whole blood and plasma specimens.	Gaibani P, Mariconti M, Bua G, Bonora S, Sassera D, Landini MP, Mulatto P, Novati S, Bandi C, Sambri V.	Biomed Res Int	10.1155/2013/264651	2013
Enzymology	High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae.	Hu Y, Palmer SO, Munoz H, Bullard JM.	Curr Drug Discov Technol	10.2174/1570163812666150120154701	2014
	Two Forms of Tyrosyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization and Discovery of Inhibitory Compounds.	Hughes CA, Gorabi V, Escamilla Y, Dean FB, Bullard JM.	SLAS Discov	10.1177/2472555220934793	2020
Pathogenicity	Commercial broth microdilution panel validation and reproducibility trials for garenoxacin (BMS-284756), a novel desfluoroquinolone.	Gordon KA, Rhomberg PR, Jones RN.	J Clin Microbiol	10.1128/jcm.41.8.3967-3969.2003	2003
Pathogenicity	Antibiotic resistance in Haemophilus influenzae decreased, except for beta-lactamase-negative amoxicillin-resistant isolates, in parallel with community antibiotic consumption in Spain from 1997 to 2007.	Garcia-Cobos S, Campos J, Cercenado E, Roman F, Lazaro E, Perez-Vazquez M, de Abajo F, Oteo J.	Antimicrob Agents Chemother	10.1128/aac.01674-07	2008
Pathogenicity	Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion.	Tarran R, Sabater JR, Clarke TC, Tan CD, Davies CM, Liu J, Yeung A, Garland AL, Stutts MJ, Abraham WM, Phillips G, Baker WR, Wright CD, Wilbert S.	Am J Physiol Lung Cell Mol Physiol	10.1152/ajplung.00292.2012	2013
	Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.	Ribble W, Hill WE, Ochsner UA, Jarvis TC, Guiles JW, Janjic N, Bullard JM.	Antimicrob Agents Chemother	10.1128/aac.00638-10	2010
	Diversity of ampicillin resistance genes and antimicrobial susceptibility patterns in Haemophilus influenzae strains isolated in Korea.	Kim IS, Ki CS, Kim S, Oh WS, Peck KR, Song JH, Lee K, Lee NY.	Antimicrob Agents Chemother	10.1128/aac.00960-06	2007
Pathogenicity	Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.	O'Dwyer K, Hackel M, Hightower S, Hoban D, Bouchillon S, Qin D, Aubart K, Zalacain M, Butler D.	Antimicrob Agents Chemother	10.1128/aac.02566-12	2013
Pathogenicity	Antimicrobial susceptibility trends among gram-positive and -negative clinical isolates collected between 2005 and 2012 in Mexico: results from the Tigecycline Evaluation and Surveillance Trial.	Morfin-Otero R, Noriega ER, Dowzicky MJ.	Ann Clin Microbiol Antimicrob	10.1186/s12941-015-0116-y	2015
Metabolism	Drug-Resistant Staphylococcus aureus Strains Reveal Distinct Biochemical Features with Raman Microspectroscopy.	Ayala OD, Wakeman CA, Pence IJ, Gaddy JA, Slaughter JC, Skaar EP, Mahadevan-Jansen A.	ACS Infect Dis	10.1021/acsinfecdis.8b00029	2018
Pathogenicity	Influence of variations in test methods on susceptibility of Haemophilus influenzae to ampicillin, azithromycin, clarithromycin, and telithromycin.	Fuchs PC, Barry AL, Brown SD.	J Clin Microbiol	10.1128/jcm.39.1.43-46.2001	2001
Pathogenicity	In vitro susceptibility testing of Haemophilus influenzae: review of new National Committee for Clinical Laboratory Standards recommendations.	Doern GV.	J Clin Microbiol	10.1128/jcm.30.12.3035-3038.1992	1992
Pathogenicity	Most commensally bacterial strains in human milk of healthy mothers display multiple antibiotic resistance.	Huang MS, Cheng CC, Tseng SY, Lin YL, Lo HM, Chen PW.	Microbiologyopen	10.1002/mbo3.618	2019
Pathogenicity	Multicenter surveillance of antimicrobial resistance of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in Taiwan during the 1998-1999 respiratory season.	Hsueh PR, Liu YC, Shyr JM, Wu TL, Yan JJ, Wu JJ, Leu HS, Chuang YC, YJ Lau, Luh KT.	Antimicrob Agents Chemother	10.1128/aac.44.5.1342-1345.2000	2000
Pathogenicity	Identification of Chemical Compounds That Inhibit the Function of Histidyl-tRNA Synthetase from Pseudomonas aeruginosa.	Hu Y, Palmer SO, Robles ST, Resto T, Dean FB, Bullard JM.	SLAS Discov	10.1177/2472555217722016	2018
	A longitudinal assessment of antimicrobial susceptibility among important pathogens collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) in France between 2004 and 2012.	Cattoir V, Dowzicky MJ.	Antimicrob Resist Infect Control	10.1186/2047-2994-3-36	2014
Pathogenicity	Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007).	Perez-Trallero E, Martin-Herrero JE, Mazon A, Garcia-Delafuente C, Robles P, Iriarte V, Dal-Re R, Garcia-de-Lomas J, Spanish Surveillance Group for Respiratory Pathogens.	Antimicrob Agents Chemother	10.1128/aac.01548-09	2010
Pathogenicity	In vitro activities of piperacillin against beta-lactamase-negative ampicillin-resistant Haemophilus influenzae.	Morikawa Y, Kitazato M, Mitsuyama J, Mizunaga S, Minami S, Watanabe Y.	Antimicrob Agents Chemother	10.1128/aac.48.4.1229-1234.2004	2004
Pathogenicity	In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea.	Yong DE, Cheong HJ, Kim YS, Park YJ, Kim WJ, Woo JH, Lee KW, Kang MW, Choo YS.	J Korean Med Sci	10.3346/jkms.2002.17.6.737	2002
Pathogenicity	Activities of ceftobiprole, a novel broad-spectrum cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis.	Bogdanovich T, Clark C, Ednie L, Lin G, Smith K, Shapiro S, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.00044-06	2006
Pathogenicity	Interpretive criteria and quality control parameters for testing susceptibility of Haemophilus influenzae to enoxacin, ofloxacin, and temafloxacin.	Barry AL, Jorgensen JH, Hardy DJ, Allen SD, Baker CN, Fuchs PC, McLaughlin JC.	J Clin Microbiol	10.1128/jcm.30.11.3013-3015.1992	1992
Enzymology	Rapid PCR detection of group A Streptococcus from flocked throat swabs: a retrospective clinical study.	Slinger R, Goldfarb D, Rajakumar D, Moldovan I, Barrowman N, Tam R, Chan F.	Ann Clin Microbiol Antimicrob	10.1186/1476-0711-10-33	2011
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in the Gulf States.	Jamsheer A, Rafay AM, Daoud Z, Morrissey I, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw064	2016
Pathogenicity	Use of the National Committee for Clinical Laboratory Standards guidelines for disk diffusion susceptibility testing in New York state laboratories.	Kiehlbauch JA, Hannett GE, Salfinger M, Archinal W, Monserrat C, Carlyn C.	J Clin Microbiol	10.1128/jcm.38.9.3341-3348.2000	2000
	Analysis of invasive Haemophilus influenzae infections after extensive vaccination against H. influenzae type b.	Campos J, Hernando M, Roman F, Perez-Vazquez M, Aracil B, Oteo J, Lazaro E, de Abajo F, Group of Invasive Haemophilus Infections of the Autonomous Community of Madrid, Spain,.	J Clin Microbiol	10.1128/jcm.42.2.524-529.2004	2004
	Survival of fastidious and nonfastidious aerobic bacteria in three bacterial transport swab systems.	Rishmawi N, Ghneim R, Kattan R, Ghneim R, Zoughbi M, Abu-Diab A, Turkuman S, Dauodi R, Shomali I, Issa Ael-R, Siriani I, Marzouka H, Schmid I, Hindiyeh MY.	J Clin Microbiol	10.1128/jcm.02110-06	2007
Phylogeny	Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in Turkey.	Soyletir G, Altinkanat G, Gur D, Altun B, Tunger A, Aydemir S, Kayacan C, Aktas Z, Gunaydin M, Karadag A, Gorur H, Morrissey I, Torumkuney D.	J Antimicrob Chemother	10.1093/jac/dkw075	2016
Pathogenicity	Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates.	Peric M, Bozdogan B, Jacobs MR, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.47.3.1017-1022.2003	2003
Pathogenicity	Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore.	Torumkuney D, Chaiwarith R, Reechaipichitkul W, Malatham K, Chareonphaibul V, Rodrigues C, Chitins DS, Dias M, Anandan S, Kanakapura S, Park YJ, Lee K, Lee H, Kim JY, Lee Y, Lee HK, Kim JH, Tan TY, Heng YX, Mukherjee P, Morrissey I.	J Antimicrob Chemother	10.1093/jac/dkw073	2016
Pathogenicity	In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.	Ge Y, Biek D, Talbot GH, Sahm DF.	Antimicrob Agents Chemother	10.1128/aac.00149-08	2008
	Development of PCR assays to detect ampicillin resistance genes in cerebrospinal fluid samples containing Haemophilus influenzae.	Tenover FC, Huang MB, Rasheed JK, Persing DH.	J Clin Microbiol	10.1128/jcm.32.11.2729-2737.1994	1994
Pathogenicity	Rapidly increasing prevalence of beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae type b in patients with meningitis.	Hasegawa K, Chiba N, Kobayashi R, Murayama SY, Iwata S, Sunakawa K, Ubukata K.	Antimicrob Agents Chemother	10.1128/aac.48.5.1509-1514.2004	2004
	The bioactivity of plant extracts against representative bacterial pathogens of the lower respiratory tract.	Bocanegra-Garcia V, Del Rayo Camacho-Corona M, Ramirez-Cabrera M, Rivera G, Garza-Gonzalez E.	BMC Res Notes	10.1186/1756-0500-2-95	2009
Phylogeny	Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children.	Pettigrew MM, Laufer AS, Gent JF, Kong Y, Fennie KP, Metlay JP.	Appl Environ Microbiol	10.1128/aem.01051-12	2012
Enzymology	Microbiological evaluation of the new VITEK 2 Neisseria-Haemophilus identification card.	Valenza G, Ruoff C, Vogel U, Frosch M, Abele-Horn M.	J Clin Microbiol	10.1128/jcm.00953-07	2007
Pathogenicity	Variability in susceptibilities of Haemophilus influenzae to clarithromycin and azithromycin due to medium pH.	Nilius AM, Beyer JM, Flamm RK, Tanaka SK.	J Clin Microbiol	10.1128/jcm.35.6.1311-1315.1997	1997
	Statistical methods for establishing quality control ranges for antibacterial agents in Clinical and Laboratory Standards Institute susceptibility testing.	Turnidge J, Bordash G.	Antimicrob Agents Chemother	10.1128/aac.01457-06	2007
Pathogenicity	Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates.	Jones RN, Fritsche TR, Sader HS.	Antimicrob Agents Chemother	10.1128/aac.00294-08	2008
Metabolism	Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors.	Barbosa MD, Yang G, Fang J, Kurilla MG, Pompliano DL.	Antimicrob Agents Chemother	10.1128/aac.46.4.943-946.2002	2002
Pathogenicity	In vitro activity of BAY 12-8039, a novel 8-methoxyquinolone, compared to activities of six fluoroquinolones against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.	Brueggemann AB, Kugler KC, Doern GV.	Antimicrob Agents Chemother	10.1128/aac.41.7.1594	1997
	Eight-plex PCR and liquid-array detection of bacterial and viral pathogens in cerebrospinal fluid from patients with suspected meningitis.	Boving MK, Pedersen LN, Moller JK.	J Clin Microbiol	10.1128/jcm.01966-08	2009
Pathogenicity	Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their beta-lactamases. Canadian Haemophilus Study Group.	Scriver SR, Walmsley SL, Kau CL, Hoban DJ, Brunton J, McGeer A, Moore TC, Witwicki E.	Antimicrob Agents Chemother	10.1128/aac.38.7.1678	1994
Pathogenicity	Interpretive criteria for susceptibilities of Haemophilus influenzae to ampicillin, amoxicillin, and amoxicillin-clavulanic acid.	Fuchs PC, Barry AL.	J Clin Microbiol	10.1128/jcm.32.11.2846-2850.1994	1994
Pathogenicity	Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997).	Doern GV, Jones RN, Pfaller MA, Kugler K.	Antimicrob Agents Chemother	10.1128/aac.43.2.385	1999
	Two-step PCR-based assay for identification of bacterial etiology of otitis media with effusion in infected Lebanese children.	Matar GM, Sidani N, Fayad M, Hadi U.	J Clin Microbiol	10.1128/jcm.36.5.1185-1188.1998	1998
	Characteristics of pyogenic odontogenic infection in patients attending Mulago Hospital, Uganda: a cross-sectional study.	Kityamuwesi R, Muwaz L, Kasangaki A, Kajumbula H, Rwenyonyi CM.	BMC Microbiol	10.1186/s12866-015-0382-z	2015
Pathogenicity	Activity of LBM415 compared to those of 11 other agents against Haemophilus species.	Bogdanovich T, Smith KA, Clark C, Pankuch GA, Lin G, McGhee P, Dewasse B, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.00106-06	2006
Pathogenicity	Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis.	Davies TA, Kelly LM, Hoellman DB, Ednie LM, Clark CL, Bajaksouzian S, Jacobs MR, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.44.3.633-639.2000	2000
	Efficacy of OH-CATH30 and its analogs against drug-resistant bacteria in vitro and in mouse models.	Li SA, Lee WH, Zhang Y.	Antimicrob Agents Chemother	10.1128/aac.06304-11	2012
Metabolism	Auxofuran, a novel metabolite that stimulates the growth of fly agaric, is produced by the mycorrhiza helper bacterium Streptomyces strain AcH 505.	Riedlinger J, Schrey SD, Tarkka MT, Hampp R, Kapur M, Fiedler HP.	Appl Environ Microbiol	10.1128/aem.72.5.3550-3557.2006	2006
	In vitro and In vivo activities of LB 10827, a new oral cephalosporin, against respiratory pathogens.	Paek KS, Kim MY, Lee CS, Youn H.	Antimicrob Agents Chemother	10.1128/aac.44.12.3272-3277.2000	2000
Pathogenicity	Comparison of agar dilution, broth dilution, and disk diffusion testing of ampicillin against Haemophilus species by using in-house and commercially prepared media.	Kohner PC, Rosenblatt JE, Cockerill FR.	J Clin Microbiol	10.1128/jcm.32.6.1594-1596.1994	1994
Pathogenicity	Reevaluation of interpretive criteria for Haemophilus influenzae by using meropenem (10-microgram), imipenem (10-microgram), and ampicillin (2- and 10-microgram) disks.	Zerva L, Biedenbach DJ, Jones RN.	J Clin Microbiol	10.1128/jcm.34.8.1970-1974.1996	1996
Pathogenicity	Susceptibilities of beta-lactamase-producing and -nonproducing ampicillin-resistant strains of Haemophilus influenzae to ceftibuten, cefaclor, cefuroxime, cefixime, cefotaxime, and amoxicillin-clavulanic acid.	Barry AL, Fuchs PC, Pfaller MA.	Antimicrob Agents Chemother	10.1128/aac.37.1.14	1993
Phylogeny	Multiplex LightCycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens.	Sloan LM, Hopkins MK, Mitchell PS, Vetter EA, Rosenblatt JE, Harmsen WS, Cockerill FR, Patel R.	J Clin Microbiol	10.1128/jcm.40.1.96-100.2002	2002
Pathogenicity	Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae.	Kosowska K, Credito K, Pankuch GA, Hoellman D, Lin G, Clark C, Dewasse B, McGhee P, Jacobs MR, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.48.11.4113-4119.2004	2004
	Identification of Chemical Compounds That Inhibit the Function of Glutamyl-tRNA Synthetase from Pseudomonas aeruginosa.	Hu Y, Guerrero E, Keniry M, Manrrique J, Bullard JM.	J Biomol Screen	10.1177/1087057115591120	2015
Pathogenicity	Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of beta-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study.	Doern GV, Brueggemann AB, Pierce G, Holley HP, Rauch A.	Antimicrob Agents Chemother	10.1128/aac.41.2.292	1997
Pathogenicity	Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.	Credito KL, Lin G, Pankuch GA, Bajaksouzian S, Jacobs MR, Appelbaum PC.	Antimicrob Agents Chemother	10.1128/aac.45.1.67-72.2001	2001
	Performance of Haemophilus Test Media prepared with 12 different lots of Mueller-Hinton agar from four manufacturers.	Barry AL, Packer RR.	J Clin Microbiol	10.1128/jcm.30.5.1145-1147.1992	1992
Pathogenicity	Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro.	Barbosa MD, Lin S, Markwalder JA, Mills JA, DeVito JA, Teleha CA, Garlapati V, Liu C, Thompson A, Trainor GL, Kurilla MG, Pompliano DL.	Antimicrob Agents Chemother	10.1128/aac.46.11.3549-3554.2002	2002
	Variation in the composition and pore function of major outer membrane pore protein P2 of Haemophilus influenzae from cystic fibrosis patients.	Regelink AG, Dahan D, Moller LV, Coulton JW, Eijk P, Van Ulsen P, Dankert J, Van Alphen L.	Antimicrob Agents Chemother	10.1128/aac.43.2.226	1999
Enzymology	Semiquantitative detection by real-time PCR of Aspergillus fumigatus in bronchoalveolar lavage fluids and tissue biopsy specimens from patients with invasive aspergillosis.	Rantakokko-Jalava K, Laaksonen S, Issakainen J, Vauras J, Nikoskelainen J, Viljanen MK, Salonen J.	J Clin Microbiol	10.1128/jcm.41.9.4304-4311.2003	2003
Pathogenicity	Survey of susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates to 26 antimicrobial agents: a prospective U.S. study.	Thornsberry C, Ogilvie PT, Holley HP, Sahm DF.	Antimicrob Agents Chemother	10.1128/aac.43.11.2612	1999
Enzymology	Development of conventional and real-time PCR assays for detection of Legionella DNA in respiratory specimens.	Rantakokko-Jalava K, Jalava J.	J Clin Microbiol	10.1128/jcm.39.8.2904-2910.2001	2001
Pathogenicity	Multicenter evaluation of the use of Haemophilus test medium for broth microdilution antimicrobial susceptibility testing of Streptococcus pneumoniae and development of quality control limits.	Jorgensen JH, Doern GV, Ferraro MJ, Knapp CC, Swenson JM, Washington JA.	J Clin Microbiol	10.1128/jcm.30.4.961-966.1992	1992
Pathogenicity	Emergence of high rates of antimicrobial resistance among viridans group streptococci in the United States.	Doern GV, Ferraro MJ, Brueggemann AB, Ruoff KL.	Antimicrob Agents Chemother	10.1128/aac.40.4.891	1996
Pathogenicity	Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997 98.	Doern GV, Brueggemann AB, Huynh H, Wingert E.	Emerg Infect Dis	10.3201/eid0506.990603	1999
	Longitudinal Assessment of Antimicrobial Susceptibility among Gram-Negative and Gram-Positive Organisms Collected from Italy as Part of the Tigecycline Evaluation and Surveillance Trial between 2004 and 2011.	Stefani S, Dowzicky MJ.	Pharmaceuticals (Basel)	10.3390/ph6111381	2013
Phylogeny	Heterogeneity of Actinobacillus actinomycetemcomitans strains in various human infections and relationships between serotype, genotype, and antimicrobial susceptibility.	Paju S, Carlson P, Jousimies-Somer H, Asikainen S.	J Clin Microbiol	10.1128/jcm.38.1.79-84.2000	2000
Pathogenicity	Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.	Doern GV, Brueggemann A, Holley HP, Rauch AM.	Antimicrob Agents Chemother	10.1128/aac.40.5.1208	1996
Pathogenicity	In vitro activities of ertapenem (MK-0826) against recent clinical bacteria collected in Europe and Australia.	Livermore DM, Carter MW, Bagel S, Wiedemann B, Baquero F, Loza E, Endtz HP, van Den Braak N, Fernandes CJ, Fernandes L, Frimodt-Moller N, Rasmussen LS, Giamarellou H, Giamarellos-Bourboulis E, Jarlier V, Nguyen J, Nord CE, Struelens MJ, Nonhoff C, Turnidge J, Bell J, Zbinden R, Pfister S, Mixson L, Shungu DL.	Antimicrob Agents Chemother	10.1128/aac.45.6.1860-1867.2001	2001
Pathogenicity	In vitro and in vivo antibacterial activities of DK-507k, a novel fluoroquinolone.	Otani T, Tanaka M, Ito E, Kurosaka Y, Murakami Y, Onodera K, Akasaka T, Sato K.	Antimicrob Agents Chemother	10.1128/aac.47.12.3750-3759.2003	2003
	Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia.	Zheljazkov VD, Cantrell CL, Semerdjieva I, Radoukova T, Stoyanova A, Maneva V, Kacaniova M, Astatkie T, Borisova D, Dincheva I, Salamon I.	Molecules	10.3390/molecules26123659	2021
	Optimizing synthetic cystic fibrosis sputum media for growth of non-typeable Haemophilus influenzae.	Do Carmo Silva P, Hill D, Harrison F.	Access Microbiol	10.1099/acmi.0.000979.v3	2025
	Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate.	Behrouzi A, Mianroodi RA, Afrough P, Ayadi A, Serajian A	Iran J Microbiol	10.18502/ijm.v12i5.4602	2020
	Prokaryotic High-Level Expression System in Producing Adhesin Recombinant Protein E of Nontypeable Haemophilus influenzae.	Tavakoli M, Bouzari S, Siadat SD, Najar Peerayeh S, Jafari A	Jundishapur J Microbiol	10.5812/jjm.8(4)2015.16377	2015
Enzymology	Overexpression and Purification of C-terminal Fragment of the Passenger Domain of Hap Protein from Nontypeable Haemophilus influenzae in a Highly Optimized Escherichia coli Expression System.	Tabatabaee A, Siadat SD, Moosavi SF, Aghasadeghi MR, Memarnejadian A, Pouriayevali MH, Yavari N	Avicenna J Med Biotechnol		2013
Pathogenicity	Quality control guidelines for cefdinir, cefepime, cefetamet, cefmetazole, cefpodoxime, cefprozil, and clinafloxacin (CI-960) for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Quality Control Study Group.	Bale MJ, Jones RN	J Clin Microbiol	10.1128/jcm.31.9.2538-2540.1993	1993
Pathogenicity	Haemophilus influenzae ATCC 49766, an alternative quality control strain for monitoring broth microdilution susceptibility tests with selected beta-lactams.	Barry AL, Jorgensen JH, Hardy DJ, Allen SD, Baker CN	J Clin Microbiol	10.1128/jcm.30.8.2033-2037.1992	1992
Pathogenicity	Development of revised quality control limits for disk diffusion susceptibility tests of selected cephem antibiotics with Haemophilus influenzae and description of a new control strain.	Jorgensen JH, Barry AL, Doern GV, Ferraro MJ, Murray PR	J Clin Microbiol	10.1128/jcm.30.8.2029-2032.1992	1992
Pathogenicity	Ceftaroline activity on certain respiratory tract and wound infection agents at the minimum inhibitory concentration level.	Yanik K, Guluzade E, Bilgin K, Karadag A, Eroglu C, Birinci A, Gunaydin M	J Infect Dev Ctries	10.3855/jidc.6300	2015
Phylogeny	Dentiradicibacter hellwigii gen. nov., sp. nov., isolated from a secondary infected root canal in the human oral cavity.	Bartsch S, Wittmer A, Weber AK, Neumann-Schaal M, Wolf J, Gronow S, Turnbull JD, Tennert C, Hacker G, Cieplik F, Al-Ahmad A.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006690	2025

References

#4562	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 11970
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#41776	; Curators of the CIP;
#49650	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 29539
#68377	Automatically annotated from API NH .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120111	Collection of Institut Pasteur ; Curators of the CIP; CIP 103570
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

Rate our new design

Content

About us

Haemophilus influenzae (CCUG 29539, DSM 11970, ATCC 49766)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Antibiotic susceptibility testing

Metabolite utilization

Antibiotic resistance

Metabolite production

Metabolite tests

Enzymes

Fatty acid profile

API zym

API NH

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900475995

16S sequences

Genome-based predictions

Literature

Literature

References

BacDive

Help

Social Media