Haemophilus influenzae 644 is a microaerophile, mesophilic, Gram-negative prokaryote that was isolated from blood and spinal fluid.
Gram-negative rod-shaped microaerophile mesophilic genome sequence 16S sequence| @ref 20215 |
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Last LPSN update
2025-12-16 09:49:39 |
| Domain Pseudomonadati |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Haemophilus |
| Species Haemophilus influenzae |
| Full scientific name Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 3772 | HAEMOPHILUS MEDIUM (DSMZ Medium 804) | Medium recipe at MediaDive  | Name: HAEMOPHILUS MEDIUM (DSMZ Medium 804) Composition: Mueller-Hinton broth 21.0 g/l Yeast extract 5.0 g/l Distilled water | ||
| 3772 | COLUMBIA BLOOD AGAR (DSMZ Medium 429) | Medium recipe at MediaDive | Name: COLUMBIA BLOOD AGAR (DSMZ Medium 429) Composition: Horse blood 40.0 g/l Columbia agar base | ||
| 36178 | MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria | Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml);PolyVitex mischung (10.000 ml) | |||
| 120107 | CIP Medium 10_BIORAD | Medium recipe at CIP | |||
| 120107 | CIP Medium 10 | Medium recipe at CIP |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68377 | beta-galactosidase | - | 3.2.1.23 | from API NH |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 3772 | catalase | + | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 3772 | cytochrome-c oxidase | + | 1.9.3.1 | |
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 68377 | ornithine decarboxylase | + | 4.1.1.17 | from API NH |
| 68377 | proline-arylamidase | - | 3.4.11.5 | from API NH |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68382 | valine arylamidase | - | from API zym |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 66792 | Haemophilus influenzae strain FDAARGOS_1561 | complete | 727.3049  | 727 | 99.07 | | |
| 124043 | ASM2073602v1 assembly for Haemophilus influenzae FDAARGOS_1561 | complete | GCA_020736025  | 727.3040 | 727 | 98.23 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children's Hospital: a cross-sectional study. | Do HD, Tran MD, Nguyen TX, Thuy Phung TB, Ngoc Hoang TB, Lien Pham TL, Nguyen M, DeAngelis E, Than HT, Nguyen KT, Guzman-Holst A. | JAC Antimicrob Resist | 10.1093/jacamr/dlaf006 | 2025 | | |
| Impact of a Single-Tube PCR Assay for the Detection of Haemophilus influenzae Serotypes a, c, d, e and f on the Epidemiological Surveillance in Greece. | Xirogianni A, Georgakopoulou T, Patsourakos V, Magaziotou I, Papandreou A, Simantirakis S, Tzanakaki G. | Microorganisms | 10.3390/microorganisms10071367 | 2022 | | |
| Epidemiological analysis and rapid detection by one-step multiplex PCR assay of Haemophilus influenzae in children with respiratory tract infections in Zhejiang Province, China. | Fan X, Liu X, Ji L, Cai D, Jiang J, Zhu J, Sun A, Yan J. | BMC Infect Dis | 10.1186/s12879-018-3295-2 | 2018 | | |
| Enzymology | Duplex Quantitative PCR Assay for Detection of Haemophilus influenzae That Distinguishes Fucose- and Protein D-Negative Strains. | de Gier C, Pickering JL, Richmond PC, Thornton RB, Kirkham LA. | J Clin Microbiol | 10.1128/jcm.00982-16 | 2016 | |
| Variable Susceptibility to Gallium Compounds of Major Cystic Fibrosis Pathogens. | Visaggio D, Frangipani E, Hijazi S, Pirolo M, Leoni L, Rampioni G, Imperi F, Bernstein L, Sorrentino R, Ungaro F, Visca P. | ACS Infect Dis | 10.1021/acsinfecdis.1c00409 | 2022 | | |
| Phylogeny | Clinical and Bacteriologic Analysis of Nontypeable Haemophilus influenzae Strains Isolated from Children with Invasive Diseases in Japan from 2008 to 2015. | Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N. | J Clin Microbiol | 10.1128/jcm.00141-18 | 2018 | |
| Enzymology | Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples. | de Filippis I, de Andrade CF, Caldeira N, de Azevedo AC, de Almeida AE. | Braz J Infect Dis | 10.1016/j.bjid.2016.04.005 | 2016 | |
| Metabolism | Adhesin genes and serum resistance in Haemophilus influenzae type f isolates. | Watson ME, Nelson KL, Nguyen V, Burnham CD, Clarridge JE, Qin X, Smith AL. | J Med Microbiol | 10.1099/jmm.0.052175-0 | 2013 | |
| Emergence of Haemophilus influenzae Strains in the Nasopharynx of Children with Tuberculosis. | Martynova AV, Balabanova LA, Pruschinskyi A. | Pulm Med | 10.1155/2011/420284 | 2011 | | |
| Enzymology | Bacteremia and malaria in Tanzanian children hospitalized for acute febrile illness. | Lundgren IS, Heltshe SL, Smith AL, Chibwana J, Fried MW, Duffy PE. | J Trop Pediatr | 10.1093/tropej/fmu069 | 2015 | |
| Determination of capsulation status in Haemophilus influenzae by multiplex polymerase chain reaction. | Nelson KL, Smith AL. | Diagn Microbiol Infect Dis | 10.1016/j.diagmicrobio.2009.10.005 | 2010 | | |
| Enzymology | Detection of Haemophilus influenzae type b by real-time PCR. | Marty A, Greiner O, Day PJ, Gunziger S, Muhlemann K, Nadal D. | J Clin Microbiol | 10.1128/jcm.42.8.3813-3815.2004 | 2004 | |
| Phylogeny | Real-time PCR for determining capsular serotypes of Haemophilus influenzae. | Maaroufi Y, De Bruyne JM, Heymans C, Crokaert F. | J Clin Microbiol | 10.1128/jcm.00102-07 | 2007 | |
| Chemically defined media for growth of Haemophilus influenzae strains. | Coleman HN, Daines DA, Jarisch J, Smith AL. | J Clin Microbiol | 10.1128/jcm.41.9.4408-4410.2003 | 2003 | | |
| Phylogeny | High level of sequence diversity in the 16S rRNA genes of Haemophilus influenzae isolates is useful for molecular subtyping. | Sacchi CT, Alber D, Dull P, Mothershed EA, Whitney AM, Barnett GA, Popovic T, Mayer LW. | J Clin Microbiol | 10.1128/jcm.43.8.3734-3742.2005 | 2005 | |
| Metabolism | Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression. | Fox KL, Dowideit SJ, Erwin AL, Srikhanta YN, Smith AL, Jennings MP. | Nucleic Acids Res | 10.1093/nar/gkm571 | 2007 | |
| Phylogeny | Evaluation of methodology for serotyping invasive and nasopharyngeal isolates of Haemophilus influenzae in the ongoing surveillance in Brazil. | Bokermann S, Zanella RC, Lemos AP, de Andrade AL, Brandileone MC. | J Clin Microbiol | 10.1128/jcm.41.12.5546-5550.2003 | 2003 | |
| Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus. | Daines DA, Jarisch J, Smith AL. | BMC Microbiol | 10.1186/1471-2180-4-30 | 2004 | | |
| Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae. | Jin H, Ren Z, Pozsgay JM, Elkins C, Whitby PW, Morton DJ, Stull TL. | Infect Immun | 10.1128/iai.64.8.3134-3141.1996 | 1996 | | |
| Enzymology | Identification and characterization of a serotype b-specific segment of the Haemophilus influenzae genome. | Ely S, Tippett J, Moxon ER. | Infect Immun | 10.1128/iai.57.9.2926-2928.1989 | 1989 | |
| Serum resistance in an invasive, nontypeable Haemophilus influenzae strain. | Williams BJ, Morlin G, Valentine N, Smith AL. | Infect Immun | 10.1128/iai.69.2.695-705.2001 | 2001 | | |
| Physical and genetic analysis of DNA regions encoding the immunoglobulin A proteases of different specificities produced by Haemophilus influenzae. | Bricker J, Mulks M, Moxon ER, Plaut AG, Wright A. | Infect Immun | 10.1128/iai.47.2.370-374.1985 | 1985 | | |
| Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae. | Chanyangam M, Smith AL, Moseley SL, Kuehn M, Jenny P. | Infect Immun | 10.1128/iai.59.2.600-608.1991 | 1991 | | |
| Bacteriophage HP2 of Haemophilus influenzae. | Williams BJ, Golomb M, Phillips T, Brownlee J, Olson MV, Smith AL. | J Bacteriol | 10.1128/jb.184.24.6893-6905.2002 | 2002 | | |
| Metabolism | Haemophilus influenzae penicillin-binding proteins 1a and 3 possess distinct and opposite temperature-modulated penicillin-binding activities. | Malouin F, Bryan LE. | Antimicrob Agents Chemother | 10.1128/aac.32.4.498 | 1988 | |
| Rates and consequences of recombination between rRNA operons. | Hashimoto JG, Stevenson BS, Schmidt TM. | J Bacteriol | 10.1128/jb.185.3.966-972.2003 | 2003 | | |
| Enzymology | Cloning of chromosomal DNA from Haemophilus influenzae. Its use for studying the expression of type b capsule and virulence. | Moxon ER, Deich RA, Connelly C. | J Clin Invest | 10.1172/jci111214 | 1984 | |
| Phylogeny | Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. | Zambon JJ, Slots J, Genco RJ. | Infect Immun | 10.1128/iai.41.1.19-27.1983 | 1983 | |
| Enzymology | DNA probe technology for rapid detection of Haemophilus influenzae in clinical specimens. | Malouin F, Bryan LE, Shewciw P, Douglas J, Li D, Van den Elzen H, Lapointe JR. | J Clin Microbiol | 10.1128/jcm.26.10.2132-2138.1988 | 1988 | |
| Cultivation | Selective culture medium to survey the incidence of Haemophilus species. | Crawford JJ, Barden L, Kirkman JB. | Appl Microbiol | 10.1128/am.18.4.646-649.1969 | 1969 | |
| Enzymology | Comparison of commercial DNA extraction kits for extraction of bacterial genomic DNA from whole-blood samples. | Smith K, Diggle MA, Clarke SC. | J Clin Microbiol | 10.1128/jcm.41.6.2440-2443.2003 | 2003 | |
| Enzymology | Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. | Corless CE, Guiver M, Borrow R, Edwards-Jones V, Fox AJ, Kaczmarski EB. | J Clin Microbiol | 10.1128/jcm.39.4.1553-1558.2001 | 2001 | |
| Phylogeny | Application of multilocus enzyme gel electrophoresis to Haemophilus influenzae. | Porras O, Caugant DA, Lagergard T, Svanborg-Eden C. | Infect Immun | 10.1128/iai.53.1.71-78.1986 | 1986 | |
| Phylogeny | Difference in structure between type b and nontypable Haemophilus influenzae populations. | Porras O, Caugant DA, Gray B, Lagergard T, Levin BR, Svanborg-Eden C. | Infect Immun | 10.1128/iai.53.1.79-89.1986 | 1986 | |
| Enzyme-linked immunosorbent assay for titration of Haemophilus influenzae capsular and O antigen antibodies. | Dahlberg T, Branefors P. | J Clin Microbiol | 10.1128/jcm.12.2.185-192.1980 | 1980 | | |
| Metabolism | Ability of oral bacteria to degrade fibronectin. | Wikstrom M, Linde A. | Infect Immun | 10.1128/iai.51.2.707-711.1986 | 1986 | |
| Genetics | Genomic analysis of the F3031 Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius by PCR-based subtractive hybridization. | Smoot LM, Franke DD, McGillivary G, Actis LA. | Infect Immun | 10.1128/iai.70.5.2694-2699.2002 | 2002 | |
| Cloning and sequencing of a genomic island found in the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius. | McGillivary G, Tomaras AP, Rhodes ER, Actis LA. | Infect Immun | 10.1128/iai.73.4.1927-1938.2005 | 2005 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive11699.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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