Haemophilus influenzae (CCUG 7316, ATCC 19418, NCTC 4560)
Haemophilus influenzae CCUG 7316 is a microaerophile bacterium of the family Pasteurellaceae.
microaerophile BacteriaName and taxonomic classification
| @ref 20215 |
Last LPSN update
2026-05-29 08:40:02 |
| Domain Bacteria |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Haemophilus |
| Species Haemophilus influenzae |
| Full scientific name Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980) |
| Synonyms (2) |
Physiology and metabolism
Oxygen tolerance
| 44969 | Oxygen tolerancemicroaerophile |
Metabolite utilization
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68377 | 15824 ChEBI | D-fructose | - | builds acid from | from API NH |
| 68377 | 17634 ChEBI | D-glucose | + | builds acid from | from API NH |
| 68377 | 17306 ChEBI | maltose | - | builds acid from | from API NH |
| 68377 | 18257 ChEBI | ornithine | - | degradation | from API NH |
| 68377 | 17992 ChEBI | sucrose | - | builds acid from | from API NH |
| 68377 | 27897 ChEBI | tryptophan | - | energy source | from API NH |
| 68377 | 16199 ChEBI | urea | + | hydrolysis | from API NH |
Enzymes
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68377 | alkaline phosphatase | + | 3.1.3.1 | from API NH |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68377 | beta-galactosidase | - | 3.2.1.23 | from API NH |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | + | 3.2.1.31 | from API zym |
| 68377 | beta-lactamase | - | 3.5.2.6 | from API NH |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68377 | gamma-glutamyltransferase | - | 2.3.2.2 | from API NH |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68377 | lipase | - | from API NH | |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 68377 | ornithine decarboxylase | - | 4.1.1.17 | from API NH |
| 68377 | proline-arylamidase | - | 3.4.11.5 | from API NH |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68377 | tryptophan deaminase | - | 4.1.99.1 | from API NH |
| 68377 | urease | + | 3.5.1.5 | from API NH |
| 68382 | valine arylamidase | - | from API zym |
API zym
Literature
Literature 
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Metabolism | Nontypeable Haemophilus influenzae exploits the interaction between protein-E and vitronectin for the adherence and invasion to bronchial epithelial cells. | Ikeda M, Enomoto N, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Suda T, Nagata T. | BMC Microbiol | 10.1186/s12866-015-0600-8 | 2015 | |
| Essential Oil Blends: The Potential of Combined Use for Respiratory Tract Infections. | Leigh-de Rapper S, Viljoen A, van Vuuren S. | Antibiotics (Basel) | 10.3390/antibiotics10121517 | 2021 | | |
| Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays. | Binks MJ, Temple B, Kirkham LA, Wiertsema SP, Dunne EM, Richmond PC, Marsh RL, Leach AJ, Smith-Vaughan HC. | PLoS One | 10.1371/journal.pone.0034083 | 2012 | | |
| Pathogenicity | An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke. | Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, Walters EH, O'Toole RF. | Int J Chron Obstruct Pulmon Dis | 10.2147/copd.s108698 | 2016 | |
| Polyphenol-Rich Larix decidua Bark Extract with Antimicrobial Activity against Respiratory-Tract Pathogens: A Novel Bioactive Ingredient with Potential Pharmaceutical and Nutraceutical Applications. | Faggian M, Bernabe G, Ferrari S, Francescato S, Baratto G, Castagliuolo I, Dall'Acqua S, Peron G. | Antibiotics (Basel) | 10.3390/antibiotics10070789 | 2021 | | |
| Intrathymic differentiation of natural antibody-producing plasma cells in human neonates. | Cordero H, King RG, Dogra P, Dufeu C, See SB, Chong AM, Uhlemann AC, Ho SH, Kalfa DM, Bacha EA, Kearney JF, Zorn E. | Nat Commun | 10.1038/s41467-021-26069-2 | 2021 | | |
| Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised controlled trial. | O'Grady KA, Grimwood K, Cripps A, Mulholland EK, Morris P, Torzillo PJ, Wood N, Smith-Vaughan H, Revell A, Wilson A, Van Asperen P, Richmond P, Thornton R, Rablin S, Chang AB. | Trials | 10.1186/1745-6215-14-282 | 2013 | | |
| Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization. | Hansen N, Rasmussen AK, Fiandaca MJ, Kragh KN, Bjarnsholt T, Hoiby N, Stender H, Guardabassi L. | New Microbes New Infect | 10.1002/nmi2.38 | 2014 | | |
| Rapid diagnosis and simultaneous identification of tuberculous and bacterial meningitis by a newly developed duplex polymerase chain reaction. | Nagdev KJ, Bhagchandani SP, Bhullar SS, Kapgate RC, Kashyap RS, Chandak NH, Daginawala HF, Purohit HJ, Taori GM. | Indian J Microbiol | 10.1007/s12088-015-0517-9 | 2015 | | |
| Tea Tree Oil: Properties and the Therapeutic Approach to Acne-A Review. | Nascimento T, Gomes D, Simoes R, da Graca Miguel M. | Antioxidants (Basel) | 10.3390/antiox12061264 | 2023 | | |
| Development of a sensitive PCR-dot blot assay to supplement serological tests for diagnosing Lyme disease. | Shah JS, D' Cruz I, Ward S, Harris NS, Ramasamy R. | Eur J Clin Microbiol Infect Dis | 10.1007/s10096-017-3162-x | 2018 | | |
| Development and evaluation of oligonucleotide chip based on the 16S-23S rRNA gene spacer region for detection of pathogenic microorganisms associated with sepsis. | Kim CM, Song ES, Jang HJ, Kim HJ, Lee S, Shin JH, Kim SJ, Jeong SH, Jeong J, Koh K, Choi GE, Lee EY, Chang CL. | J Clin Microbiol | 10.1128/jcm.01130-09 | 2010 | | |
| The Oligopeptide Permease Opp Mediates Illicit Transport of the Bacterial P-site Decoding Inhibitor GE81112. | Maio A, Brandi L, Donadio S, Gualerzi CO. | Antibiotics (Basel) | 10.3390/antibiotics5020017 | 2016 | | |
| Comparison of outer membrane protein and biochemical profiles of Haemophilus aegyptius and Haemophilus influenzae biotype III. | Carlone GM, Sottnek FO, Plikaytis BD. | J Clin Microbiol | 10.1128/jcm.22.5.708-713.1985 | 1985 | | |
| Elfamycins: inhibitors of elongation factor-Tu. | Prezioso SM, Brown NE, Goldberg JB. | Mol Microbiol | 10.1111/mmi.13750 | 2017 | | |
| AOAC-OMA/MicroVal Harmonized Validation of Peel PlateTM EB (Enterobacteriaceae Bacteria), First Action 2018.05. | Salter RS, Durbin GW, Martinez D, Bird P, Bastin B, Crowley E. | J AOAC Int | 10.1093/jaoacint/qsaa067 | 2020 | | |
| Metabolism | Growth of Haemophilus influenzae in simulated blood cultures supplemented with hemin and NAD. | Artman M, Domenech E, Weiner M. | J Clin Microbiol | 10.1128/jcm.18.2.376-379.1983 | 1983 | |
| Metabolism | Penicillin-binding proteins in Haemophilus influenzae. | Makover SD, Wright R, Telep E. | Antimicrob Agents Chemother | 10.1128/aac.19.4.584 | 1981 | |
| Pathogenicity | Susceptibility testing of macrolide antibiotics against Haemophilus influenzae and correlation of in vitro results with in vivo efficacy in a mouse septicemia model. | Fernandes PB, Hardy D, Bailer R, McDonald E, Pintar J, Ramer N, Swanson R, Gade E. | Antimicrob Agents Chemother | 10.1128/aac.31.8.1243 | 1987 | |
| Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections. | Hu X, Huang YY, Wang Y, Wang X, Hamblin MR. | Front Microbiol | 10.3389/fmicb.2018.01299 | 2018 | | |
| Antigenic heterogeneity of lipid A of Haemophilus influenzae. | Apicella MA, Dudas KC, Campagnari A, Rice P, Mylotte JM, Murphy TF. | Infect Immun | 10.1128/iai.50.1.9-14.1985 | 1985 | | |
| Enzymology | New centrifugation blood culture device. | Dorn GL, Smith K. | J Clin Microbiol | 10.1128/jcm.7.1.52-54.1978 | 1978 | |
| Phylogeny | Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. | Zambon JJ, Slots J, Genco RJ. | Infect Immun | 10.1128/iai.41.1.19-27.1983 | 1983 | |
| Enzymology | Evidence for the presence of Simkania negevensis in drinking water and in reclaimed wastewater in Israel. | Kahane S, Platzner N, Dvoskin B, Itzhaki A, Friedman MG. | Appl Environ Microbiol | 10.1128/aem.70.6.3346-3351.2004 | 2004 | |
| Pathogenicity | A40926, a new glycopeptide antibiotic with anti-Neisseria activity. | Goldstein BP, Selva E, Gastaldo L, Berti M, Pallanza R, Ripamonti F, Ferrari P, Denaro M, Arioli V, Cassani G. | Antimicrob Agents Chemother | 10.1128/aac.31.12.1961 | 1987 | |
| Metabolism | Ability of oral bacteria to degrade fibronectin. | Wikstrom M, Linde A. | Infect Immun | 10.1128/iai.51.2.707-711.1986 | 1986 | |
| Metabolism | Rapid, inexpensive method for specific detection of microbial beta-lactamases by detection of fluorescent end products. | Chen KC, Knapp JS, Holmes KK. | J Clin Microbiol | 10.1128/jcm.19.6.818-825.1984 | 1984 | |
| Analysis of major antigens of Haemophilus (Actinobacillus) pleuropneumoniae and related organisms. | MacInnes JI, Rosendal S. | Infect Immun | 10.1128/iai.55.7.1626-1634.1987 | 1987 | | |
| Phylogeny | Morphological, biochemical, antigenic, and cytochemical relationships among Haemophilus somnus, Haemophilus agni, Haemophilus haemoglobinophilus, Histophilus ovis, and Actinobacillus seminis. | Stephens LR, Humphrey JD, Little PB, Barnum DA. | J Clin Microbiol | 10.1128/jcm.17.5.728-737.1983 | 1983 | |
| Two-dimensional thin-layer chromatography for simultaneous detection of bacterial beta-lactam acylases and beta-lactamases. | Chen KC. | Antimicrob Agents Chemother | 10.1128/aac.30.4.536 | 1986 | | |
| Molecular cloning and characterization of a hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniae. | Lian CJ, Rosendal S, MacInnes JI. | Infect Immun | 10.1128/iai.57.11.3377-3382.1989 | 1989 | | |
| Pathogenicity | Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15-membered macrolides in Staphylococcus epidermidis. | Goldman RC, Capobianco JO. | Antimicrob Agents Chemother | 10.1128/aac.34.10.1973 | 1990 | |
| Optimizing synthetic cystic fibrosis sputum media for growth of non-typeable Haemophilus influenzae. | Do Carmo Silva P, Hill D, Harrison F. | Access Microbiol | 10.1099/acmi.0.000979.v3 | 2025 | | |
| Enzymology | Impact of eosinophil-peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways. | Percopo CM, Krumholz JO, Fischer ER, Kraemer LS, Ma M, Laky K, Rosenberg HF. | J Leukoc Biol | 10.1002/jlb.3ab0318-090rr | 2019 | |
| Limited diversity of the immunoglobulin A1 protease gene (iga) among Haemophilus influenzae serotype b strains. | Poulsen K, Hjorth JP, Kilian M. | Infect Immun | 10.1128/iai.56.4.987-992.1988 | 1988 | | |
| Enzymology | Evaluation of some methods for the laboratory identification of Haemophilus influenzae. | Tebbutt GM. | J Clin Pathol | 10.1136/jcp.36.9.991 | 1983 | |
| Pathogenicity | Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships. | Atherton FR, Hall MJ, Hassall CH, Holmes SW, Lambert RW, Lloyd WJ, Ringrose PS. | Antimicrob Agents Chemother | 10.1128/aac.18.6.897 | 1980 | |
| Metabolism | Tetracycline levels in bronchial secretions. | Campbell MJ. | J Clin Pathol | 10.1136/jcp.23.5.427 | 1970 | |
| Phosphonopeptides as antibacterial agents: rationale, chemistry, and structure-activity relationships. | Atherton FR, Hall MJ, Hassall CH, Lambert RW, Ringrose PS. | Antimicrob Agents Chemother | 10.1128/aac.15.5.677 | 1979 | | |
| Enzymology | Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease. | Kilian M, Mestecky J, Schrohenloher RE. | Infect Immun | 10.1128/iai.26.1.143-149.1979 | 1979 | |
| Metabolism | Erythromycin and azithromycin transport into Haemophilus influenzae ATCC 19418 under conditions of depressed proton motive force (delta mu H). | Capobianco JO, Goldman RC | Antimicrob Agents Chemother | 10.1128/AAC.34.9.1787 | 1990 | |
| Pathogenicity | Ampicillin-induced morphological alterations of Haemophilus influenzae type b. | Klein RD, Luginbuhl GH | Antimicrob Agents Chemother | 10.1128/AAC.11.3.559 | 1977 | |
How to cite
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive141822.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain dataIsabel Schober, Julia Koblitz, Joaquim Sardà Carbasse, Christian Ebeling, Marvin Leon Schmidt, Adam Podstawka, Rohit Gupta, Vinodh Ilangovan, Javad Chamanara, Jörg Overmann, Lorenz Christian Reimer
Nucleic Acids Research; database issue 2025.
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