Name: Haemophilus influenzae TD-4
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 11705

Type strain:

Species: Haemophilus influenzae

Strain Designation: TD-4

Culture col. no.: DSM 24049, ATCC 49247, CCUG 26214, DSM 9999, NCTC 12699, CIP 104604

Strain history: CIP <- 1995, ATCC <- G.V. Doern: strain TD-4

NCBI tax ID(s): 727 (species)

SI-ID 2985

LMG 11197, ATCC 49247, CCUG 26214, CIP 104604, DSM 9999, NCTC 12699, CCM 4456, CNCTC 5063, BCRC 17028, CCRC 17028, ACM 5054, DSM 24049

Other strains from Haemophilus influenzae

Section

Haemophilus influenzae TD-4 is a microaerophile, mesophilic, Gram-negative bacterium that was isolated from human sputum, pneumonia patient.

Gram-negative
mesophilic
microaerophile
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Pseudomonadota*
	Class	*Gammaproteobacteria*
	Order	*Pasteurellales*
	Family	*Pasteurellaceae*
	Genus	*Haemophilus*
	Species	**Haemophilus influenzae**
	Full Scientific Name (LPSN)	Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980)

	Synonym	Hemophilus influenzae
	Synonym	"Bacterium* influenzae"*

Information on morphological and physiological properties Morphology

[Ref.: #120109]	Gram stain	negative
[Ref.: #69480]	Gram stain	negative Confidence in %99.969

[Ref.: #120109]	Cell shape	rod-shaped

[Ref.: #120109]	Motility	no

[Ref.: #17317]	Type of hemolysis	gamma
[Ref.: #17317]	Incubation period	1-2 days

Information on culture and growth conditions Culture and growth conditions

[Ref.: #17317]

Culture medium

HAEMOPHILUS MEDIUM (DSMZ Medium 804)

[Ref.: #17317]

Culture medium growth

[Ref.: #17317]

Culture medium link

Medium recipe at MediaDive

[Ref.: #17317]

Culture medium composition

expand / minimize

[Ref.: #39696]

Culture medium

MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria

[Ref.: #39696]

Culture medium growth

[Ref.: #39696]

Culture medium composition

expand / minimize

[Ref.: #120109]

Culture medium

CIP Medium 10

[Ref.: #120109]

Culture medium growth

[Ref.: #120109]

Culture medium link

Medium recipe provided by DSMZ

	Kind of temperature		Temperature
[Ref.: #17317]		growth	37 °C
[Ref.: #39696]		growth	37 °C
[Ref.: #120109]		growth	25-41 °C
[Ref.: #120109]	no	growth	45 °C

[Ref.: #17317]	Temperature range	mesophilic
[Ref.: #39696]	Temperature range	mesophilic
[Ref.: #120109]	Temperature range	thermophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #17317]	Oxygen tolerance	microaerophile
[Ref.: #120109]	Oxygen tolerance	facultative anaerobe

Note that the displayed test results represent raw data and therefore may deviate!

Antibiotic susceptibility testing

Test 1

Test 2

Test 3

Test 4

Reference

[Ref.: #17317]
M 804
37
1
microaerophil
yes
Inhibition zone diameter in mm
14
resistant0
20
32
32
12-14
22
34-36
36
28
20
40
20
20-22
resistant0
16
12
38
38-40
18
26
30
resistant0
20
22
16
24
34-36
18
42
34-36
22
resistant0
20
10
36

[Ref.: #17317]
M 804
37
1
microaerophil
yes
Inhibition zone diameter in mm
16
resistant0
20-22
34
34
26-28
24
38-40
40
30
20
40
22
24-26
resistant0
20
16
40
38-40
18
28
34-36
resistant0
20
26
18
24
38-40
20
48-50
38-40
26
resistant0
20
10
38

[Ref.: #17317]
M 804



yes
Inhibition zone diameter in mm
16
resistant0
22
32-34
32
24-26
26
38
38
32
20
40
20
22-24
resistant0
18
12-14
40
38
18
24-26
32
resistant0
18
24
18-20
24-26
40
18
50
40
16-18
8
20-22
10
38

[Ref.: #17317]
M 804
37

microaerophil
yes
Inhibition zone diameter in mm
12
resistant0
20
30-32
30
10
16-18
36
34
28
18
34
18
20
resistant0
16-18
10
36
36-38
16
24
24-26
resistant0
16
22
16-18
22
36
8
32
36-38
20
resistant0
16-18
6-8
34

Only first 15 entries are displayed. Click here to see all.

[Ref.: #69481]	Ability of spore formation	no Confidence in %100
[Ref.: #69480]	Ability of spore formation	no Confidence in %99.996

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68377]	D-glucose ChEBI	+	builds acid from	* from API NH
[Ref.: #120109]	esculin ChEBI	-	hydrolysis
[Ref.: #120109]	hippurate ChEBI	+	hydrolysis
[Ref.: #120109]	nitrate ChEBI	+	reduction
[Ref.: #120109]	nitrite ChEBI	-	reduction

	Metabolite production	Metabolite	Production
[Ref.: #120109]		indole ChEBI	yes

	Enzyme	Enzyme activity	EC number
[Ref.: #68382]	acid phosphatase	+	3.1.3.2	* from API zym
[Ref.: #120109]	alcohol dehydrogenase	-	1.1.1.1
[Ref.: #68382]	alkaline phosphatase	+	3.1.3.1	* from API zym
[Ref.: #68382]	alpha-chymotrypsin	-	3.4.21.1	* from API zym
[Ref.: #68382]	alpha-fucosidase	-	3.2.1.51	* from API zym
[Ref.: #68382]	alpha-galactosidase	-	3.2.1.22	* from API zym
[Ref.: #68382]	alpha-glucosidase	-	3.2.1.20	* from API zym
[Ref.: #68382]	alpha-mannosidase	-	3.2.1.24	* from API zym
[Ref.: #120109]	beta-galactosidase	-	3.2.1.23
[Ref.: #68377]	beta-galactosidase	-	3.2.1.23	* from API NH, API zym
[Ref.: #68382]	beta-glucosidase	-	3.2.1.21	* from API zym
[Ref.: #68382]	beta-glucuronidase	-	3.2.1.31	* from API zym
[Ref.: #17317]	catalase	+	1.11.1.6
[Ref.: #120109]	catalase	+	1.11.1.6
[Ref.: #68382]	cystine arylamidase	-	3.4.11.3	* from API zym
[Ref.: #17317]	cytochrome-c oxidase	+	1.9.3.1
[Ref.: #68382]	esterase (C 4)	+		* from API zym
[Ref.: #68382]	esterase lipase (C 8)	+		* from API zym
[Ref.: #120109]	gamma-glutamyltransferase	-	2.3.2.2
[Ref.: #68382]	leucine arylamidase	+	3.4.11.1	* from API zym
[Ref.: #68382]	lipase (C 14)	-		* from API zym
[Ref.: #120109]	lysine decarboxylase	+	4.1.1.18
[Ref.: #68382]	N-acetyl-beta-glucosaminidase	-	3.2.1.52	* from API zym
[Ref.: #68382]	naphthol-AS-BI-phosphohydrolase	+		* from API zym
[Ref.: #120109]	ornithine decarboxylase	+	4.1.1.17
[Ref.: #120109]	oxidase	+
[Ref.: #68382]	trypsin	-	3.4.21.4	* from API zym
[Ref.: #120109]	urease	+	3.5.1.5
[Ref.: #68382]	valine arylamidase	-		* from API zym
	Only first 10 entries are displayed. Click here to see all.

Fatty acid profile

Metadata FA analysis

Reference

[Ref.: #48391]

Fatty acid	Percentage	ECL
C16:1 ω7c	38.1	15.819
C16:0	32.3	16
C14:0	18.8	14
C14:0 3OH/C16:1 ISO I	7.8	15.485
C18:0	1	18
C18:1 ω7c /12t/9t	0.7	17.824
C18:2 ω6,9c/C18:0 ANTE	0.6	17.724
C13:0 ISO 2OH	0.4	13.814
unknown 14.503	0.4	14.503

API® Biotype100:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
[Ref.: #120109]	728	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

API® NH:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Penicillinase productionPEN	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from maltoseMAL	Acid from sucroseSAC	Ornithine decarboxylaseODC	Urease/urea hydrolysisURE	LipaseLIP	Alkaline phosphatasePAL	beta-Galactosidasebeta GAL	Proline arylamidaseProA	gamma-Glutamyl transferaseGGT	Indole productionIND
[Ref.: #17317]	6220	+	+	-	+/-	+	+	-	+	-	-	-	+	-
[Ref.: #17317]	6219	+	+	-	+	+	+	-	+	-	-	+	+	-
[Ref.: #17317]	6218	+	+	-	-	+	+	-	+	-	-	-	+	-
[Ref.: #17317]	5960	-	+	+	-	-	+	+	-	+	-	-	+/-	+
[Ref.: #17317]	5916	-	+	+	+/-	+/-	+	+	-	+	-	-	+	+
[Ref.: #17317]	5654	-	+	+	-	-	+	+	-	+	-	-	-	+
[Ref.: #17317]	5653	-	+	+	-	+	+	+	-	+	-	-	+	+
[Ref.: #17317]	5652	-	+	+	-	+/-	+	+	-	+	-	-	-	+
[Ref.: #17317]	6291	-	+	+	-	-	-	+	-	+	-	-	-	+

API® zym:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Control	2-naphthyl phosphateAlkaline phosphatase	2-naphthyl butyrateEsterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	2-naphthyl myristateLipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	N-benzoyl-DL-arginine-2-naphthylamideTrypsin	N-glutaryl-phenylalanine-2-naphthylamidealpha- Chymotrypsin	2-naphthyl phosphateAcid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	6-Br-2-naphthyl-alphaD-galactpyranosidealpha- Galactosidase	2-naphthyl-betaD-galactpyranosidebeta- Galactosidase	Naphthol-AS-BI-betaD-glucuronidebeta- Glucuronidase	2-naphthyl-alphaD-glucopyranosidealpha- Glucosidase	6-Br-2-naphthyl-betaD-glucopyranosidebeta- Glucosidase	1-naphthyl-N-acetyl-betaD-glucosaminideN-acetyl-beta- glucosaminidase	6-Br-2-naphthyl-alphaD-mannopyranosidealpha- Mannosidase	2-naphthyl-alphaL-fucopyranosidealpha- Fucosidase
[Ref.: #120109]	8069	-	+	+	+	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #17317]	Sample type/isolated from	human sputum, pneumonia patient
[Ref.: #17317]	Geographic location (country and/or sea, region)	Massachusetts
[Ref.: #17317]	Country	USA
[Ref.: #17317]	Country ISO 3 Code	USA
[Ref.: #17317]	Continent	North America
[Ref.: #17317]	Geographic location	42.4072°/-71.3824°

[Ref.: #48391]	Sample type/isolated from	Human sputum,pneumonia patient
[Ref.: #48391]	Geographic location (country and/or sea, region)	Massachusetts
[Ref.: #48391]	Country	USA
[Ref.: #48391]	Country ISO 3 Code	USA
[Ref.: #48391]	Continent	North America

[Ref.: #120109]	Sample type/isolated from	Human, Sputum
[Ref.: #120109]	Geographic location (country and/or sea, region)	Massachusetts
[Ref.: #120109]	Country	United States of America
[Ref.: #120109]	Country ISO 3 Code	USA
[Ref.: #120109]	Continent	North America
* marker position based on {}

Isolation sources categories

#Infection	#Disease	-
#Infection	#Patient	-
#Host	#Human	-
#Host Body Product	#Fluids	#Sputum

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #17317]	Biosafety level	2	Risk group (German classification) According to TRBA 466
[Ref.: #120109]	Biosafety level	2	Risk group (French classification)

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Haemophilus influenzae NCTC12699	GCA_900635805	complete	GenBank	727 tax ID	*
[Ref.: #66792]	Haemophilus influenzae CCUG 26214	GCA_001679235	scaffold	GenBank	727 tax ID	*
[Ref.: #66792]	Haemophilus influenzae strain CCUG 26214	727.965	wgs	PATRIC	727 tax ID	*
[Ref.: #66792]	Haemophilus influenzae strain NCTC12699	727.1824	complete	PATRIC	727 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Haemophilus influenzae NCTC12699 NCBI: GCA_900635805.1
[Ref.: #69481]	spore-forming	no	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Haemophilus influenzae NCTC12699 NCBI: GCA_900635805.1
[Ref.: #69480]	flagellated	no	96.871	no
[Ref.: #69480]	gram-positive	no	97.769	no
[Ref.: #69480]	anaerobic	no	94.582	yes
[Ref.: #69480]	aerobic	no	95.608	yes
[Ref.: #69480]	halophile	no	51.695	no
[Ref.: #69480]	spore-forming	no	98.414	no
[Ref.: #69480]	thermophile	no	97.879	yes
[Ref.: #69480]	glucose-util	yes	53.58	no
[Ref.: #69480]	motile	no	92.312	no
[Ref.: #69480]	glucose-ferment	yes	52.234	no

Availability in culture collections External links

[Ref.: #17317]

Culture collection no.

DSM 24049, ATCC 49247, CCUG 26214, DSM 9999, NCTC 12699, CIP 104604

[Ref.: #80925]

SI-ID 2985

Literature:

Only first 10 entries are displayed. Click here to see all.

	Title	Authors	Journal	DOI	Year
Cultivation	Determination of MIC Quality Control Ranges for the Novel Gyrase Inhibitor Zoliflodacin.	Miller AA, Traczewski MM, Huband MD, Bradford PA, Mueller JP	J Clin Microbiol	10.1128/JCM.00567-19	2019	*
Pathogenicity	Determination of Disk Diffusion and MIC Quality Control Ranges for Nafithromycin (WCK 4873), a New Lactone-Ketolide.	Hackel MA, Karlowsky JA, Dressel D, Sahm DF	J Clin Microbiol	10.1128/JCM.00972-17	2017	*
Pathogenicity	Implementation of the new VIRTUO blood culture system: evaluation and comparison to the 3D system using simulated blood cultures.	Miller N, Brassinne L, Allemeersch D	Acta Clin Belg	10.1080/17843286.2017.1331618	2017	*
Metabolism	[Mouse macrophage-derived chemokine as an adjuvant enhances the protective effect of P6 protein vaccine of nontypeable Haemophilus influenzae].	Han X, Wang C, Qiao H, Zhang Y, Chang Y, Zhang Y	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi		2014	*
Pathogenicity	Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent.	Ross JE, Scangarella-Oman NE, Flamm RK, Jones RN	J Clin Microbiol	10.1128/JCM.00656-14	2014	*
Pathogenicity	Activity of the antiseptic polyhexanide against gram-negative bacteria.	Fabry WH, Kock HJ, Vahlensieck W	Microb Drug Resist	10.1089/mdr.2013.0113	2013	*
Pathogenicity	Determination of disk diffusion and MIC quality control guidelines for GSK2251052: a novel boron-containing antibacterial.	Ross JE, Scangarella-Oman N, Jones RN	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2013.01.007	2013	*
Pathogenicity	Antimicrobial susceptibility testing of Streptococcus pneumoniae and Haemophilus influenzae --internal quality control as a quality tool on a national level.	Karpanoja P, Nissinen A, Huovinen P, Sarkkinen H	APMIS	10.1111/apm.12021	2012	*
Pathogenicity	Antimicrobial and antioxidant properties of Betula aetnensis Rafin. (Betulaceae) leaves extract.	Acquaviva R, Menichini F, Ragusa S, Genovese C, Amodeo A, Tundis R, Loizzo MR, Iauk L	Nat Prod Res	10.1080/14786419.2012.695364	2012	*
Pathogenicity	Determination of disk diffusion and MIC quality control ranges for GSK1322322, a novel peptide deformylase inhibitor.	Ross JE, Scangarella-Oman NE, Miller LA, Sader HS, Jones RN	J Clin Microbiol	10.1128/JCM.01213-11	2011	*
Pathogenicity	Determination of disk diffusion and MIC quality control guidelines for JNJ-Q2, a novel quinolone.	Ross JE, Liverman LC, Jones RN	J Clin Microbiol	10.1128/JCM.00636-11	2011	*
Enzymology	[Cloning Hap gene from non-typeable Haemophilus influenzae and expression of Hap protein in prokaryotic cell].	Li W, Kuang Y, Yao F, Yang Y, Chen C, Jiang Z, Li M	Sheng Wu Yi Xue Gong Cheng Xue Za Zhi		2009	*
Enzymology	[Species-identification and antimicrobial susceptibility tests by the fully automated RAISUS using an early-harvested cell suspension].	Nakasone I, Kisanuki K, Higa M, Kinjo T, Yamane N	Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi		2006	*
Cultivation	Comparative in vitro antimicrobial activity of tigecycline, a new glycylcycline compound, in freshly prepared medium and quality control.	Brown SD, Traczewski MM	J Clin Microbiol	10.1128/JCM.02351-06	2007	*
Pathogenicity	Impact of carbon dioxide on the susceptibility of key respiratory tract pathogens to telithromycin and azithromycin.	Bouchillon SK, Johnson JL, Hoban DJ, Stevens TM, Johnson BM	J Antimicrob Chemother	10.1093/jac/dki156	2005	*
Pathogenicity	Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor.	Anderegg TR, Jones RN	Diagn Microbiol Infect Dis	10.1016/S0732-8893(03)00162-7	2004	*
Pathogenicity	Re-evaluation of quality control guidelines for gatifloxacin and garenoxacin (BMS284756) when susceptibility testing Haemophilus influenzae and Streptococcus pneumoniae.	Anderegg TR, Biedenbach DJ, Jones RN	Diagn Microbiol Infect Dis	10.1016/s0732-8893(03)00039-7	2003	*
Pathogenicity	Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids. Discovery of the novel des-F(6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756).	Hayashi K, Takahata M, Kawamura Y, Todo Y	Arzneimittelforschung	10.1055/s-0031-1299988	2002	*
Phylogeny	Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae.	Dabernat H, Delmas C, Seguy M, Pelissier R, Faucon G, Bennamani S, Pasquier C	Antimicrob Agents Chemother	10.1128/AAC.46.7.2208-2218.2002	2002	*
Enzymology	Influence of CO(2) incubation on quinolone activity against Streptococcus pneumoniae and Haemophilus influenzae.	Bolmstrom A, Karlsson A	Diagn Microbiol Infect Dis	10.1016/s0732-8893(01)00338-8	2002	*
Pathogenicity	Assessment of BMS284756 MIC and 5-microg disk diffusion quality control studies tested against seven American type culture collection strains.	Biedenbach DJ, Jones RN	Diagn Microbiol Infect Dis	10.1016/s0732-8893(01)00294-2	2001	*
Pathogenicity	Validation of cefditoren MIC quality control ranges by a multi-laboratory study (2001).	Jones RN, Biedenbach DJ	Diagn Microbiol Infect Dis	10.1016/s0732-8893(01)00236-x	2001	*
Cultivation	Evaluation of quinupristin/dalfopristin (Synercid) and RPR 106972 stability in susceptibility testing media.	Marshall SA, Kugler KC, Jones RN	Int J Antimicrob Agents	10.1016/s0924-8579(00)00180-1	2000	*
Phylogeny	Activity of gatifloxacin against Haemophilus influenzae and Moraxella catarrhalis, including susceptibility test development, E-test comparisons, and quality control guidelines for H. influenzae.	Jones RN, Biedenbach DJ, Erwin ME, Beach ML, Pfaller MA	J Clin Microbiol	10.1128/JCM.37.6.1999-2002.1999	1999	*
Pathogenicity	Escherichia coli ATCC 35218 as a quality control isolate for susceptibility testing of Haemophilus influenzae with haemophilus test medium.	Butler DL, Jakielaszek CJ, Miller LA, Poupard JA	Antimicrob Agents Chemother	10.1128/AAC.43.2.283	1999	*
Pathogenicity	Microbiologic effect of bovine cerebrospinal fluid and azithromycin against Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae.	Destache CJ, Pakiz CB, Kersting K	Pharmacotherapy		1997	*
Pathogenicity	Interpretive criteria and quality control parameters for testing of susceptibilities of Haemophilus influenzae and Streptococcus pneumoniae to trimethoprim and trimethoprim-sulfamethoxazole. The Antimicrobial Susceptibility Testing OC Group.	Fuchs PC, Barry AL, Brown SD	J Clin Microbiol	10.1128/jcm.35.1.125-131.1997	1997	*
Pathogenicity	Tentative criteria for determining the in vitro susceptibilities of Haemophilus influenzae, including quality control parameters, to two fluoroquinolones (grepafloxacin and PD 131628).	Sewell DL, Barry AL, Allen SD, Fuchs PC, Jorgensen JH, Tenover F	Diagn Microbiol Infect Dis	10.1016/0732-8893(95)00021-2	1995	*
Pathogenicity	Minimum inhibitory concentration quality-control guidelines for biapenem, DU-6859a, FK-037, levofloxacin, grepafloxacin, and ceftizoxime when using various National Committee for Clinical Laboratory Standards susceptibility test methods. Quality Control Study Group.	Bale MJ, Jones RN, Erwin ME	Diagn Microbiol Infect Dis	10.1016/0732-8893(94)90054-x	1994	*
Pathogenicity	Agar disk diffusion (Bauer-Kirby) tests with various fastidious and nonfastidious reference (ATCC) strains: comparison of several agar media.	Traub WH, Leonhard B	Chemotherapy	10.1159/000239296	1994	*
Pathogenicity	Tentative criteria for confirming the in vitro susceptibilities of Haemophilus influenzae and Neisseria gonorrhoeae to two fluoroquinolones (sparfloxacin and levofloxacin), including quality control parameters.	Barry AL, Fuchs PC, Allen SD, Jorgensen JH, Tenover FC, Murray PR, Hardy DJ, Baker CN	J Clin Microbiol	10.1128/jcm.31.9.2375-2380.1993	1993	*
Pathogenicity	Susceptibility of Haemophilus influenzae to piperacillin-tazobactam combinations: interpretive criteria and quality control limits for standardized tests.	Barry AL, Fuchs PC, Jorgensen JH, Tenover FC, Allen SD, Hardy DJ, McLaughlin JC	J Clin Microbiol	10.1128/jcm.31.3.751-753.1993	1993	*
Pathogenicity	Interpretive criteria and quality control parameters for testing susceptibility of Haemophilus influenzae to enoxacin, ofloxacin, and temafloxacin.	Barry AL, Jorgensen JH, Hardy DJ, Allen SD, Baker CN, Fuchs PC, McLaughlin JC	J Clin Microbiol	10.1128/jcm.30.11.3013-3015.1992	1992	*
Cultivation	Performance of Haemophilus Test Media prepared with 12 different lots of Mueller-Hinton agar from four manufacturers.	Barry AL, Packer RR	J Clin Microbiol	10.1128/jcm.30.5.1145-1147.1992	1992	*
Pathogenicity	Disk diffusion quality control guidelines for Haemophilus susceptibility tests using cefdinir, CI-960, fleroxacin, temafloxacin, and trospectomycin.	Bale MJ, Jones RN, Erwin ME, Koontz FP, Gerlach EH, Murray PR, Washington JA	J Clin Microbiol	10.1128/jcm.30.3.744-745.1992	1992	*
Pathogenicity	Interpretive criteria and quality control guidelines for lomefloxacin and meropenem in susceptibility tests of Haemophilus influenzae using Haemophilus test medium.	Pfaller MA, Jones RN, Washington JA, Koontz FP, Gerlach EH, Erwin ME	Diagn Microbiol Infect Dis	10.1016/0732-8893(92)90039-v	1992	*
Pathogenicity	MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin.	Bale MJ, Jones RN, Erwin ME, Koontz FP, Gerlach EH, Murray PR, Washington JA	J Clin Microbiol	10.1128/jcm.30.1.225-226.1992	1992	*
Cultivation	Quality control limits for disk diffusion and broth microdilution susceptibility tests with Haemophilus test medium.	Doern GV, Gerlach EH, Jorgensen JH, Murray PR, Thornsberry C, Washington JA Jr	Diagn Microbiol Infect Dis	10.1016/0732-8893(91)90004-y	1991	*
	Endophytic Fungi from Alstonia boonei De Wild and Greenwayodendron suaveolens (Engl. and Diels) Verdc. subsp. Suaveolens Possess Inhibitory Activity against Pneumonia Causing Bacteria.	Demeni PCE, Betote PHD, Kom CW, Tchamgoue EN, Ndedi Moni EDF, Foumane Maniepi JS, Agbor GA, Nyegue MA	Evid Based Complement Alternat Med	10.1155/2021/9966323	2021	*
	Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens.	Srifuengfung S, Bunyapraphatsara N, Satitpatipan V, Tribuddharat C, Junyaprasert VB, Tungrugsasut W, Srisukh V	J Tradit Complement Med	10.1016/j.jtcme.2019.09.003	2019	*
	Antibacterial, Antioxidant, and Antiproliferative Activities of Corymbia citriodora and the Essential Oils of Eight Eucalyptus Species.	Miguel MG, Gago C, Antunes MD, Lagoas S, Faleiro ML, Megias C, Cortes-Giraldo I, Vioque J, Figueiredo AC	Medicines (Basel)	10.3390/medicines5030061	2018	*

References

#17317

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 24049

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#39696 ; Curators of the CIP;
#48391 Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 26214

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68377

Automatically annotated from API NH .

#68382

Automatically annotated from API zym .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#80925

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID2985.1 )

#120109 Collection of Institut Pasteur ; Curators of the CIP; CIP 104604
* These data were automatically processed and therefore are not curated

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