Haemophilus influenzae KW20 is a microaerophile, mesophilic, Gram-negative prokaryote of the family Pasteurellaceae.
Gram-negative rod-shaped microaerophile mesophilic genome sequence| @ref 20215 |
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Last LPSN update
2026-02-09 11:20:38 |
| Domain Bacteria |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Haemophilus |
| Species Haemophilus influenzae |
| Full scientific name Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 4213 | HAEMOPHILUS MEDIUM (DSMZ Medium 804) | Medium recipe at MediaDive  | Name: HAEMOPHILUS MEDIUM (DSMZ Medium 804) Composition: Mueller-Hinton broth 21.0 g/l Yeast extract 5.0 g/l Distilled water | ||
| 4213 | COLUMBIA BLOOD AGAR (DSMZ Medium 429) | Medium recipe at MediaDive | Name: COLUMBIA BLOOD AGAR (DSMZ Medium 429) Composition: Horse blood 40.0 g/l Columbia agar base | ||
| 39820 | MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria | Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml);PolyVitex mischung (10.000 ml) | |||
| 120106 | CIP Medium 10 | Medium recipe at CIP |
| 4213 | Oxygen tolerancemicroaerophile |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 27613 ChEBI | amygdalin | - | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | - | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | - | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | - | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 50CH acid |
| 68371 | 16024 ChEBI | D-mannose | - | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | - | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | + | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 68371 | 4853 ChEBI | esculin | - | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | - | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | - | builds acid from | from API 50CH acid |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | + | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17716 ChEBI | lactose | - | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | + | builds acid from | from API 50CH acid |
| 68377 | 17306 ChEBI | maltose | - | builds acid from | from API NH |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 28053 ChEBI | melibiose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | + | builds acid from | from API 50CH acid |
| 120106 | 17632 ChEBI | nitrate | + | reduction | |
| 120106 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | Potassium 5-ketogluconate | + | builds acid from | from API 50CH acid | |
| 68371 | 16634 ChEBI | raffinose | - | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | - | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | - | builds acid from | from API 50CH acid |
| 68371 | 27082 ChEBI | trehalose | - | builds acid from | from API 50CH acid |
| 68377 | 27897 ChEBI | tryptophan | - | energy source | from API NH |
| 68371 | 32528 ChEBI | turanose | + | builds acid from | from API 50CH acid |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 120106 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 120106 | beta-galactosidase | - | 3.2.1.23 | |
| 68377 | beta-galactosidase | - | 3.2.1.23 | from API NH |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 120106 | catalase | + | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68377 | gamma-glutamyltransferase | - | 2.3.2.2 | from API NH |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 120106 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 120106 | ornithine decarboxylase | + | 4.1.1.17 | |
| 120106 | oxidase | - | ||
| 68377 | proline-arylamidase | - | 3.4.11.5 | from API NH |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68377 | tryptophan deaminase | - | 4.1.99.1 | from API NH |
| 120106 | urease | + | 3.5.1.5 | |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 120106 | not determinedn.d. | - | - | - | - | - | + | - | - | - | - | + | - | - | - | - | - | - | - | - | - | - | + | - | - | - | - | - | + | - | - | +/- | - | - | - | - | - | - | - | - | + | - | - | - | + | - | - | - | - | + |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 124043 | ASM3709470v1 assembly for Haemophilus influenzae Rd-KW20 | complete | GCA_037094705   | 727.4060  | 727 | 99.56 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Genetics | Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae. | Diricks M, Petersen S, Bartels L, Lam TT, Claus H, Bajanca-Lavado MP, Hauswaldt S, Stolze R, Vazquez OJ, Utpatel C, Niemann S, Rupp J, Wohlers I, Merker M. | Genome Med | 10.1186/s13073-024-01406-4 | 2024 | |
| Bioproduction of propionic acid using levulinic acid by engineered Pseudomonas putida. | Tiwari R, Sathesh-Prabu C, Lee SK. | Front Bioeng Biotechnol | 10.3389/fbioe.2022.939248 | 2022 | | |
| Large-scale evolutionary analyses on SecB subunits of bacterial sec system. | Yan S, Wu G. | PLoS One | 10.1371/journal.pone.0120417 | 2015 | | |
| Metabolism | A SLC6 transporter cloned from the lion's mane jellyfish (Cnidaria, Scyphozoa) is expressed in neurons. | Bouchard C, Boudko DY, Jiang RHY. | PLoS One | 10.1371/journal.pone.0218806 | 2019 | |
| Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones | Skaare D, Anthonisen I, Zecic N, Jenkins A, Caugant D, Ranheim T, Sundsfjord A, Hegstad K. | Front Microbiol | 2025 | | ||
| Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to beta-lactams. | Jakubu V, Cechova M, Musilek M, Malisova L, Zapletalova B, Zemlickova H. | J Antimicrob Chemother | 10.1093/jac/dkaf023 | 2025 | | |
| Prevalence of piperacillin/tazobactam resistance in invasive Haemophilus influenzae in Germany. | Duske H, Claus H, Krone M, Lam TT. | JAC Antimicrob Resist | 10.1093/jacamr/dlad148 | 2024 | | |
| Genetics | Multiple interspecies recombination events documented by whole-genome sequencing in multidrug-resistant Haemophilus influenzae clinical isolates. | Michel C, Argudin MA, Wautier M, Echahidi F, Prevost B, Vandenberg O, Martiny D, Hallin M. | Access Microbiol | 10.1099/acmi.0.000649.v3 | 2024 | |
| Structure and inhibition of diaminopimelic acid epimerase by slow-binding alpha-methyl amino acids. | Lamer T, Chen P, Catenza K, Perov I, L B, Hsiao YT, Van Oers TJ, Lemieux MJ, Vederas JC. | Protein Sci | 10.1002/pro.70139 | 2025 | | |
| The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-com-ponent regulatory mechanism. | Koo JS, Kang SM, Jung WM, Kim DH, Lee BJ. | IUCrJ | 10.1107/s205225252200687x | 2022 | | |
| The complete genome sequence of a bile-isolated Stenotrophomonas maltophilia ZT1. | Zhang M, Li L, Pan H, Zhou T. | Gut Pathog | 10.1186/s13099-021-00456-y | 2021 | | |
| Characterization of Haemophilus influenzae Strains with Non-Enzymatic Resistance to beta-Lactam Antibiotics Caused by Mutations in the PBP3 Gene in the Czech Republic in 2010-2018. | Jakubu V, Malisova L, Musilek M, Pomorska K, Zemlickova H. | Life (Basel) | 10.3390/life11111260 | 2021 | | |
| Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies. | Wong SM, Gawronski J, Akerley BJ. | Infect Immun | 10.1128/iai.00091-23 | 2023 | | |
| Metabolism | Rapid identification of methylase specificity (RIMS-seq) jointly identifies methylated motifs and generates shotgun sequencing of bacterial genomes. | Baum C, Lin YC, Fomenkov A, Anton BP, Chen L, Yan B, Evans TC, Roberts RJ, Tolonen AC, Ettwiller L. | Nucleic Acids Res | 10.1093/nar/gkab705 | 2021 | |
| Metabolism | Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens. | Salillas S, Sancho J. | Int J Mol Sci | 10.3390/ijms21051881 | 2020 | |
| Metabolism | Antibiotic Korormicin A Kills Bacteria by Producing Reactive Oxygen Species. | Maynard A, Butler NL, Ito T, da Silva AJ, Murai M, Chen T, Koffas MAG, Miyoshi H, Barquera B. | J Bacteriol | 10.1128/jb.00718-18 | 2019 | |
| Phylogeny | Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB. | Zwama M, Yamaguchi A, Nishino K. | Commun Biol | 10.1038/s42003-019-0564-6 | 2019 | |
| Pathogenicity | Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion. | Kitaoka K, Kimura K, Kitanaka H, Banno H, Jin W, Wachino JI, Arakawa Y. | Antimicrob Agents Chemother | 10.1128/aac.00671-18 | 2018 | |
| Pathogenicity | Cross-Reactivity as a Mechanism Linking Infections to Stroke. | Lucchese G, Floel A, Stahl B. | Front Neurol | 10.3389/fneur.2019.00469 | 2019 | |
| HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger. | Jubrail J, Africano-Gomez K, Herit F, Baturcam E, Mayer G, Cunoosamy DM, Kurian N, Niedergang F. | Front Immunol | 10.3389/fimmu.2018.02908 | 2018 | | |
| Inflammatory response of Haemophilus influenzae biotype aegyptius causing Brazilian Purpuric Fever. | Cury GC, Pereira RF, de Hollanda LM, Lancellotti M. | Braz J Microbiol | 10.1590/s1517-83822014000400040 | 2014 | | |
| sll1019 and slr1259 encoding glyoxalase II improve tolerance of Synechocystis sp. PCC 6803 to methylglyoxal- and ethanol- induced oxidative stress by glyoxalase pathway. | Ji K, Zhang Y, Zhang T, Li D, Yuan Y, Wang L, Huang Q, Chen W. | Appl Environ Microbiol | 10.1128/aem.00564-24 | 2024 | | |
| A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria. | Sankari S, Babu VMP, Bian K, Alhhazmi A, Andorfer MC, Avalos DM, Smith TA, Yoon K, Drennan CL, Yaffe MB, Lourido S, Walker GC. | Nat Microbiol | 10.1038/s41564-022-01192-y | 2022 | | |
| Metabolism | Prediction of enzymatic pathways by integrative pathway mapping. | Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, Gerlt JA, Jacobson MP, Shoichet BK, Sali A. | Elife | 10.7554/elife.31097 | 2018 | |
| Enzymology | Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae. | Nakamura S, Yanagihara K, Morinaga Y, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno S. | J Clin Microbiol | 10.1128/jcm.01645-08 | 2009 | |
| Pathogenicity | Discovery and Characterization of a Nitroreductase Capable of Conferring Bacterial Resistance to Chloramphenicol. | Crofts TS, Sontha P, King AO, Wang B, Biddy BA, Zanolli N, Gaumnitz J, Dantas G. | Cell Chem Biol | 10.1016/j.chembiol.2019.01.007 | 2019 | |
| Novel antimicrobial activities of a peptide derived from a Japanese soybean fermented food, Natto, against Streptococcus pneumoniae and Bacillus subtilis group strains. | Kitagawa M, Shiraishi T, Yamamoto S, Kutomi R, Ohkoshi Y, Sato T, Wakui H, Itoh H, Miyamoto A, Yokota SI. | AMB Express | 10.1186/s13568-017-0430-1 | 2017 | | |
| Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents. | Shrestha SK, Fosso MY, Green KD, Garneau-Tsodikova S. | Antimicrob Agents Chemother | 10.1128/aac.00229-15 | 2015 | | |
| A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing. | Raven KE, Girgis ST, Akram A, Blane B, Leek D, Brown N, Peacock SJ. | Sci Rep | 10.1038/s41598-020-80031-8 | 2021 | | |
| Enzymology | Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial lung pathogens, a mouse model study. | Zhu J, Bean HD, Jimenez-Diaz J, Hill JE. | J Appl Physiol (1985) | 10.1152/japplphysiol.00099.2013 | 2013 | |
| Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection. | Zhang L, Xie J, Patel M, Bakhtyar A, Ehrlich GD, Ahmed A, Earl J, Marrs CF, Clemans D, Murphy TF, Gilsdorf JR. | PLoS One | 10.1371/journal.pone.0044730 | 2012 | | |
| Pathogenicity | In vitro activities of garenoxacin (BMS-284756) against Haemophilus influenzae isolates with different fluoroquinolone susceptibilities. | Perez-Vazquez M, Roman F, Aracil B, Canton R, Campos J. | Antimicrob Agents Chemother | 10.1128/aac.47.11.3539-3541.2003 | 2003 | |
| Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants. | Trepod CM, Mott JE. | Antimicrob Agents Chemother | 10.1128/aac.48.4.1416-1418.2004 | 2004 | | |
| In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class. | Mani N, Gross CH, Parsons JD, Hanzelka B, Muh U, Mullin S, Liao Y, Grillot AL, Stamos D, Charifson PS, Grossman TH. | Antimicrob Agents Chemother | 10.1128/aac.50.4.1228-1237.2006 | 2006 | | |
| Metabolism | Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae. | Buurman ET, Foulk MA, Gao N, Laganas VA, McKinney DC, Moustakas DT, Rose JA, Shapiro AB, Fleming PR. | J Bacteriol | 10.1128/jb.01103-12 | 2012 | |
| Enzymology | Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations. | Perez-Vazquez M, Roman F, Aracil B, Canton R, Campos J. | J Clin Microbiol | 10.1128/jcm.42.3.1185-1191.2004 | 2004 | |
| The dppBCDF gene cluster of Haemophilus influenzae: Role in heme utilization. | Morton DJ, Seale TW, Vanwagoner TM, Whitby PW, Stull TL. | BMC Res Notes | 10.1186/1756-0500-2-166 | 2009 | | |
| Metabolism | OpsX from Haemophilus influenzae represents a novel type of heptosyltransferase I in lipopolysaccharide biosynthesis. | Gronow S, Brabetz W, Lindner B, Brade H. | J Bacteriol | 10.1128/jb.187.17.6242-6247.2005 | 2005 | |
| Transcriptional profile of Haemophilus influenzae: effects of iron and heme. | Whitby PW, Vanwagoner TM, Seale TW, Morton DJ, Stull TL. | J Bacteriol | 10.1128/jb.00417-06 | 2006 | | |
| Pathogenicity | Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance. | Berkov-Zrihen Y, Green KD, Labby KJ, Feldman M, Garneau-Tsodikova S, Fridman M. | J Med Chem | 10.1021/jm400707f | 2013 | |
| Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. | Grossman TH, Bartels DJ, Mullin S, Gross CH, Parsons JD, Liao Y, Grillot AL, Stamos D, Olson ER, Charifson PS, Mani N. | Antimicrob Agents Chemother | 10.1128/aac.00596-06 | 2007 | | |
| Characterization and evaluation of antimicrobial activity of actinonin against foodborne pathogens. | Jung D, Yum SJ, Jeong HG. | Food Sci Biotechnol | 10.1007/s10068-017-0190-3 | 2017 | | |
| Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity. | Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. | Medchemcomm | 10.1039/c4md00572d | 2015 | | |
| Horizontal gene transfer of ftsI, encoding penicillin-binding protein 3, in Haemophilus influenzae. | Takahata S, Ida T, Senju N, Sanbongi Y, Miyata A, Maebashi K, Hoshiko S. | Antimicrob Agents Chemother | 10.1128/aac.01545-06 | 2007 | | |
| Pathogenicity | Antibiotic resistance in Haemophilus influenzae decreased, except for beta-lactamase-negative amoxicillin-resistant isolates, in parallel with community antibiotic consumption in Spain from 1997 to 2007. | Garcia-Cobos S, Campos J, Cercenado E, Roman F, Lazaro E, Perez-Vazquez M, de Abajo F, Oteo J. | Antimicrob Agents Chemother | 10.1128/aac.01674-07 | 2008 | |
| Pathogenicity | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. | Garcia-Cobos S, Campos J, Roman F, Carrera C, Perez-Vazquez M, Aracil B, Oteo J. | Antimicrob Agents Chemother | 10.1128/aac.00214-08 | 2008 | |
| Metabolism | Prevalence of genetic differences in phosphorylcholine expression between nontypeable Haemophilus influenzae and Haemophilus haemolyticus. | McCrea KW, Xie J, Marrs CF, Gilsdorf JR. | BMC Microbiol | 10.1186/1471-2180-10-286 | 2010 | |
| Pathogenicity | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. | Cerquetti M, Giufre M, Cardines R, Mastrantonio P. | Antimicrob Agents Chemother | 10.1128/aac.00335-07 | 2007 | |
| Pathogenicity | A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria. | Fan J, de Jonge BL, MacCormack K, Sriram S, McLaughlin RE, Plant H, Preston M, Fleming PR, Albert R, Foulk M, Mills SD. | Antimicrob Agents Chemother | 10.1128/aac.03475-14 | 2014 | |
| Pathogenicity | Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number. | Dean CR, Narayan S, Richards J, Daigle DM, Esterow S, Leeds JA, Kamp H, Puyang X, Wiedmann B, Mueller D, Voshol H, van Oostrum J, Wall D, Koehn J, Dzink-Fox J, Ryder NS. | Antimicrob Agents Chemother | 10.1128/aac.01103-06 | 2007 | |
| Phylogeny | Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains. | McCrea KW, Xie J, LaCross N, Patel M, Mukundan D, Murphy TF, Marrs CF, Gilsdorf JR. | J Clin Microbiol | 10.1128/jcm.01832-07 | 2008 | |
| Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo. | Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS. | Antimicrob Agents Chemother | 10.1128/aac.01181-10 | 2011 | | |
| rrndb: the Ribosomal RNA Operon Copy Number Database. | Klappenbach JA, Saxman PR, Cole JR, Schmidt TM. | Nucleic Acids Res | 10.1093/nar/29.1.181 | 2001 | | |
| Enzymology | Selective microbial genomic DNA isolation using restriction endonucleases. | Barnes HE, Liu G, Weston CQ, King P, Pham LK, Waltz S, Helzer KT, Day L, Sphar D, Yamamoto RT, Forsyth RA. | PLoS One | 10.1371/journal.pone.0109061 | 2014 | |
| Pathogenicity | Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays. | Wu P, Lawrence LE, Denbleyker KL, Barrett JF. | Antimicrob Agents Chemother | 10.1128/aac.45.12.3660-3662.2001 | 2001 | |
| Phylogeny | Dynamics of long-term colonization of respiratory tract by Haemophilus influenzae in cystic fibrosis patients shows a marked increase in hypermutable strains. | Roman F, Canton R, Perez-Vazquez M, Baquero F, Campos J. | J Clin Microbiol | 10.1128/jcm.42.4.1450-1459.2004 | 2004 | |
| Metabolism | Haemophilus influenzae Rd lacks a stringently conserved fatty acid biosynthetic enzyme and thermal control of membrane lipid composition. | Wang H, Cronan JE. | J Bacteriol | 10.1128/jb.185.16.4930-4937.2003 | 2003 | |
| Pathogenicity | In vitro selection of resistance in Haemophilus influenzae by amoxicillin-clavulanate, cefpodoxime, cefprozil, azithromycin, and clarithromycin. | Clark C, Bozdogan B, Peric M, Dewasse B, Jacobs MR, Appelbaum PC. | Antimicrob Agents Chemother | 10.1128/aac.46.9.2956-2962.2002 | 2002 | |
| Pathogenicity | Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. | Eakin AE, Green O, Hales N, Walkup GK, Bist S, Singh A, Mullen G, Bryant J, Embrey K, Gao N, Breeze A, Timms D, Andrews B, Uria-Nickelsen M, Demeritt J, Loch JT, Hull K, Blodgett A, Illingworth RN, Prince B, Boriack-Sjodin PA, Hauck S, MacPherson LJ, Ni H, Sherer B. | Antimicrob Agents Chemother | 10.1128/aac.05485-11 | 2012 | |
| Enzymology | The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli. | Okada K, Minehira M, Zhu X, Suzuki K, Nakagawa T, Matsuda H, Kawamukai M. | J Bacteriol | 10.1128/jb.179.9.3058-3060.1997 | 1997 | |
| Copy number of pilus gene clusters in Haemophilus influenzae and variation in the hifE pilin gene. | Read TD, Satola SW, Opdyke JA, Farley MM. | Infect Immun | 10.1128/iai.66.4.1622-1631.1998 | 1998 | | |
| Pathogenicity | Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI). | de Jonge BL, Kutschke A, Uria-Nickelsen M, Kamp HD, Mills SD. | Antimicrob Agents Chemother | 10.1128/aac.00226-09 | 2009 | |
| Pathogenicity | Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. | Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K, Takeuchi Y, Sunakawa K, Inoue M, Konno M. | Antimicrob Agents Chemother | 10.1128/aac.45.6.1693-1699.2001 | 2001 | |
| Global versus local regulatory roles for Lrp-related proteins: Haemophilus influenzae as a case study. | Friedberg D, Midkiff M, Calvo JM. | J Bacteriol | 10.1128/jb.183.13.4004-4011.2001 | 2001 | | |
| Pathogenicity | Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus. | Lahiri SD, Kutschke A, McCormack K, Alm RA. | Antimicrob Agents Chemother | 10.1128/aac.00571-15 | 2015 | |
| Pathogenicity | Peptide deformylase as an antibacterial drug target: target validation and resistance development. | Apfel CM, Locher H, Evers S, Takacs B, Hubschwerlen C, Pirson W, Page MG, Keck W. | Antimicrob Agents Chemother | 10.1128/aac.45.4.1058-1064.2001 | 2001 | |
| Enzymology | The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. | Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET. | J Biol Chem | 10.1074/jbc.m114.574061 | 2014 | |
| Genetics | Divergence and redundancy of 16S rRNA sequences in genomes with multiple rrn operons. | Acinas SG, Marcelino LA, Klepac-Ceraj V, Polz MF, Polz MF. | J Bacteriol | 10.1128/jb.186.9.2629-2635.2004 | 2004 | |
| Metabolism | A novel 3-deoxy-D-manno-octulosonic acid (Kdo) hydrolase that removes the outer Kdo sugar of Helicobacter pylori lipopolysaccharide. | Stead C, Tran A, Ferguson D, McGrath S, Cotter R, Trent S. | J Bacteriol | 10.1128/jb.187.10.3374-3383.2005 | 2005 | |
| Phylogeny | Variability of outer membrane protein P1 and its evaluation as a vaccine candidate against experimental otitis media due to nontypeable Haemophilus influenzae: an unambiguous, multifaceted approach. | Bolduc GR, Bouchet V, Jiang RZ, Geisselsoder J, Truong-Bolduc QC, Rice PA, Pelton SI, Goldstein R. | Infect Immun | 10.1128/iai.68.8.4505-4517.2000 | 2000 | |
| Pathogenicity | Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. | de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. | Antimicrob Agents Chemother | 10.1128/aac.01661-13 | 2013 | |
| Rates and consequences of recombination between rRNA operons. | Hashimoto JG, Stevenson BS, Schmidt TM. | J Bacteriol | 10.1128/jb.185.3.966-972.2003 | 2003 | | |
| Improvement of the pharmacokinetics and in vivo antibacterial efficacy of a novel type IIa topoisomerase inhibitor by formulation in liposomes. | Shapiro AB, Newman J, Goteti K, Beaudoin ME, Harrison R, Hopkins S, Agrawal N, Rivin O. | Antimicrob Agents Chemother | 10.1128/aac.00163-13 | 2013 | | |
| Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis. | Kurnasov OV, Polanuyer BM, Ananta S, Sloutsky R, Tam A, Gerdes SY, Osterman AL. | J Bacteriol | 10.1128/jb.184.24.6906-6917.2002 | 2002 | | |
| Phylogeny | Typing of nonencapsulated haemophilus strains by repetitive-element sequence-based PCR using intergenic dyad sequences. | Bruant G, Watt S, Quentin R, Rosenau A. | J Clin Microbiol | 10.1128/jcm.41.8.3473-3480.2003 | 2003 | |
| Enzymology | Diverse mutations in the ftsI gene in ampicillin-resistant Haemophilus influenzae isolates from pediatric patients with acute otitis media. | Kishii K, Chiba N, Morozumi M, Hamano-Hasegawa K, Kurokawa I, Masaki J, Ubukata K | J Infect Chemother | 10.1007/s10156-009-0011-6 | 2010 | |
| Enzymology | 3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli. | Brabetz W, Muller-Loennies S, Brade H | J Biol Chem | 10.1074/jbc.M005204200 | 2000 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive11701.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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