Haemophilus influenzae 641 is a microaerophile bacterium that was isolated from spinal fluid of patient with meningitis.
microaerophile genome sequence 16S sequence Bacteria| @ref 20215 |
Last LPSN update
2026-05-29 08:27:37 |
| Domain Bacteria |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Haemophilus |
| Species Haemophilus influenzae |
| Full scientific name Haemophilus influenzae corrig. (Lehmann and Neumann 1896) Winslow et al. 1917 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 3773 | HAEMOPHILUS MEDIUM (DSMZ Medium 804) | Medium recipe at MediaDive  | Name: HAEMOPHILUS MEDIUM (DSMZ Medium 804) Composition: Mueller-Hinton broth 21.0 g/l Yeast extract 5.0 g/l Distilled water | ||
| 3773 | COLUMBIA BLOOD AGAR (DSMZ Medium 429) | Medium recipe at MediaDive | Name: COLUMBIA BLOOD AGAR (DSMZ Medium 429) Composition: Horse blood 40.0 g/l Columbia agar base |
| @ref | Growth | Type | Temperature (°C) | |
|---|---|---|---|---|
| 3773 | positive | growth | 37 |
| Cat1 | Cat2 | Cat3 | |
|---|---|---|---|
| #Infection | #Disease | #Meningitis | |
| #Infection | #Patient | - | |
| #Host Body Product | #Fluids | #Cerebrospinal fluid |
Global distribution of 16S sequence AY613700 (>99% sequence identity) for Haemophilus influenzae from Microbeatlas 
 Aquatic Samples |
597 |
 Soil Samples |
173 |
 Animal Samples |
30711 |
 Plant Samples |
55 |
| Total Samples | 31536 |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 124043 | ASM1993070v1 assembly for Haemophilus influenzae FDAARGOS_1479 | complete | GCA_019930705   | 727.3022  | 727 | 99.25 |  |
| 66792 | Haemophilus influenzae strain FDAARGOS_1479 | complete | 727.3034 | 727 | 99.25 | | |
| 66792 | Haemophilus influenzae strain FDAARGOS_1479 | complete | 727.3043 | 727 | 99.25 | | |
| 66792 | Haemophilus influenzae strain FDAARGOS_1479 | complete | 727.3030 | 727 | 99.25 | |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 20218 | Haemophilus influenzae strain ATCC9795 16S ribosomal RNA gene, partial sequence | AY613700 | 1538 |  | 727 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Enzymology | Bacterial nonspecific acid phosphohydrolases: physiology, evolution and use as tools in microbial biotechnology. | Rossolini GM, Schippa S, Riccio ML, Berlutti F, Macaskie LE, Thaller MC. | Cell Mol Life Sci | 10.1007/s000180050212 | 1998 | |
| Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children's Hospital: a cross-sectional study. | Do HD, Tran MD, Nguyen TX, Thuy Phung TB, Ngoc Hoang TB, Lien Pham TL, Nguyen M, DeAngelis E, Than HT, Nguyen KT, Guzman-Holst A. | JAC Antimicrob Resist | 10.1093/jacamr/dlaf006 | 2025 | | |
| Enzymology | Bacteremia and malaria in Tanzanian children hospitalized for acute febrile illness. | Lundgren IS, Heltshe SL, Smith AL, Chibwana J, Fried MW, Duffy PE. | J Trop Pediatr | 10.1093/tropej/fmu069 | 2015 | |
| Determination of capsulation status in Haemophilus influenzae by multiplex polymerase chain reaction. | Nelson KL, Smith AL. | Diagn Microbiol Infect Dis | 10.1016/j.diagmicrobio.2009.10.005 | 2010 | | |
| Metabolism | Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity. | Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S. | Int J Nanomedicine | 10.2147/ijn.s30467 | 2012 | |
| Phylogeny | Real-time PCR for determining capsular serotypes of Haemophilus influenzae. | Maaroufi Y, De Bruyne JM, Heymans C, Crokaert F. | J Clin Microbiol | 10.1128/jcm.00102-07 | 2007 | |
| Chemically defined media for growth of Haemophilus influenzae strains. | Coleman HN, Daines DA, Jarisch J, Smith AL. | J Clin Microbiol | 10.1128/jcm.41.9.4408-4410.2003 | 2003 | | |
| Metabolism | Peptides selected for binding to a virulent strain of Haemophilus influenzae by phage display are bactericidal. | Bishop-Hurley SL, Schmidt FJ, Erwin AL, Smith AL. | Antimicrob Agents Chemother | 10.1128/aac.49.7.2972-2978.2005 | 2005 | |
| Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain. | Galdiero M, D'Amico M, Gorga F, Di Filippo C, D'Isanto M, Vitiello M, Longanella A, Tortora A. | Infect Immun | 10.1128/iai.69.1.221-227.2001 | 2001 | | |
| Haemophilus influenzae porin induces Toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages. | Galdiero M, Galdiero M, Finamore E, Rossano F, Gambuzza M, Catania MR, Teti G, Midiri A, Mancuso G. | Infect Immun | 10.1128/iai.72.2.1204-1209.2004 | 2004 | | |
| Phylogeny | High level of sequence diversity in the 16S rRNA genes of Haemophilus influenzae isolates is useful for molecular subtyping. | Sacchi CT, Alber D, Dull P, Mothershed EA, Whitney AM, Barnett GA, Popovic T, Mayer LW. | J Clin Microbiol | 10.1128/jcm.43.8.3734-3742.2005 | 2005 | |
| Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus. | Daines DA, Jarisch J, Smith AL. | BMC Microbiol | 10.1186/1471-2180-4-30 | 2004 | | |
| Antigenic sites on porin of Haemophilus influenzae type b: mapping with synthetic peptides and evaluation of structure predictions. | Srikumar R, Dahan D, Gras MF, Ratcliffe MJ, van Alphen L, Coulton JW. | J Bacteriol | 10.1128/jb.174.12.4007-4016.1992 | 1992 | | |
| Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade. | Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M. | Infect Immun | 10.1128/iai.71.5.2798-2809.2003 | 2003 | | |
| A rapid and sensitive chemiluminescence assay for evaluation of functional opsonic activity of Haemophilus influenzae type b-specific antibodies. | Ojo-Amaize EA, Church JA, Barka NE, Agopian MS, Peter JB. | Clin Diagn Lab Immunol | 10.1128/cdli.2.3.286-290.1995 | 1995 | | |
| Haemophilus influenzae type b isolates show antigenic variation in a major outer membrane protein. | Erwin AL, Kenny GE. | Infect Immun | 10.1128/iai.46.2.570-577.1984 | 1984 | | |
| Pathogenicity | Molecular basis of the non-beta-lactamase-mediated resistance to beta-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada. | Clairoux N, Picard M, Brochu A, Rousseau N, Gourde P, Beauchamp D, Parr TR, Bergeron MG, Malouin F. | Antimicrob Agents Chemother | 10.1128/aac.36.7.1504 | 1992 | |
| Pathogenicity | Rapid method for determining antimicrobial susceptibility of Haemophilus influenzae. | Smith JA, Ngui-Yen JH, Fothergill J, Porter D. | J Clin Microbiol | 10.1128/jcm.16.5.832-835.1982 | 1982 | |
| Evolution of the major pilus gene cluster of Haemophilus influenzae. | Mhlanga-Mutangadura T, Morlin G, Smith AL, Eisenstark A, Golomb M. | J Bacteriol | 10.1128/jb.180.17.4693-4703.1998 | 1998 | | |
| Evolution of an autotransporter: domain shuffling and lateral transfer from pathogenic Haemophilus to Neisseria. | Davis J, Smith AL, Hughes WR, Golomb M. | J Bacteriol | 10.1128/jb.183.15.000-000.2001 | 2001 | | |
| Serum resistance in an invasive, nontypeable Haemophilus influenzae strain. | Williams BJ, Morlin G, Valentine N, Smith AL. | Infect Immun | 10.1128/iai.69.2.695-705.2001 | 2001 | | |
| The tryptophanase gene cluster of Haemophilus influenzae type b: evidence for horizontal gene transfer. | Martin K, Morlin G, Smith A, Nordyke A, Eisenstark A, Golomb M. | J Bacteriol | 10.1128/jb.180.1.107-118.1998 | 1998 | | |
| Enzymology | Examination of Haemophilus pleuropneumoniae for immunoglobulin A protease activity. | Mulks MH, Moxon ER, Bricker J, Wright A, Plaut AG. | Infect Immun | 10.1128/iai.45.1.276-277.1984 | 1984 | |
| Enzymology | Use of an enrichment broth cultivation-PCR combination assay for rapid diagnosis of swine erysipelas. | Shimoji Y, Mori Y, Hyakutake K, Sekizaki T, Yokomizo Y. | J Clin Microbiol | 10.1128/jcm.36.1.86-89.1998 | 1998 | |
| Physical and genetic analysis of DNA regions encoding the immunoglobulin A proteases of different specificities produced by Haemophilus influenzae. | Bricker J, Mulks M, Moxon ER, Plaut AG, Wright A. | Infect Immun | 10.1128/iai.47.2.370-374.1985 | 1985 | | |
| Bacteriophage HP2 of Haemophilus influenzae. | Williams BJ, Golomb M, Phillips T, Brownlee J, Olson MV, Smith AL. | J Bacteriol | 10.1128/jb.184.24.6893-6905.2002 | 2002 | | |
| Metabolism | Protein sources of heme for Haemophilus influenzae. | Stull TL. | Infect Immun | 10.1128/iai.55.1.148-153.1987 | 1987 | |
| Metabolism | Growth of Haemophilus influenzae in simulated blood cultures supplemented with hemin and NAD. | Artman M, Domenech E, Weiner M. | J Clin Microbiol | 10.1128/jcm.18.2.376-379.1983 | 1983 | |
| Metabolism | Haemophilus influenzae penicillin-binding proteins 1a and 3 possess distinct and opposite temperature-modulated penicillin-binding activities. | Malouin F, Bryan LE. | Antimicrob Agents Chemother | 10.1128/aac.32.4.498 | 1988 | |
| Pathogenicity | Susceptibility testing of macrolide antibiotics against Haemophilus influenzae and correlation of in vitro results with in vivo efficacy in a mouse septicemia model. | Fernandes PB, Hardy D, Bailer R, McDonald E, Pintar J, Ramer N, Swanson R, Gade E. | Antimicrob Agents Chemother | 10.1128/aac.31.8.1243 | 1987 | |
| Transmembrane permeability channels across the outer membrane of Haemophilus influenzae type b. | Vachon V, Lyew DJ, Coulton JW. | J Bacteriol | 10.1128/jb.162.3.918-924.1985 | 1985 | | |
| Phylogeny | Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. | Zambon JJ, Slots J, Genco RJ. | Infect Immun | 10.1128/iai.41.1.19-27.1983 | 1983 | |
| Enzymology | DNA probe technology for rapid detection of Haemophilus influenzae in clinical specimens. | Malouin F, Bryan LE, Shewciw P, Douglas J, Li D, Van den Elzen H, Lapointe JR. | J Clin Microbiol | 10.1128/jcm.26.10.2132-2138.1988 | 1988 | |
| Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli. | Gilbert JV, Plaut AG, Fishman Y, Wright A. | Infect Immun | 10.1128/iai.56.8.1961-1966.1988 | 1988 | | |
| Metabolism | Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids. | Krivan HC, Roberts DD, Ginsburg V. | Proc Natl Acad Sci U S A | 10.1073/pnas.85.16.6157 | 1988 | |
| Serum antibody response to outer membrane proteins of Moraxella (Branhamella) catarrhalis in patients with bronchopulmonary infection. | Christensen JJ, Hansen NQ, Bruun B. | Clin Diagn Lab Immunol | 10.1128/cdli.3.6.717-721.1996 | 1996 | | |
| Enzymology | Selective medium for the isolation of Haemophilus aphrophilus from the human periodontium and other oral sites and the low proportion of the organism in the oral flora. | Tempro PJ, Slots J. | J Clin Microbiol | 10.1128/jcm.23.4.777-782.1986 | 1986 | |
| Enzymology | Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. | Corless CE, Guiver M, Borrow R, Edwards-Jones V, Fox AJ, Kaczmarski EB. | J Clin Microbiol | 10.1128/jcm.39.4.1553-1558.2001 | 2001 | |
| Metabolism | Synthesis of histamine by Haemophilus influenzae. | Sheinman BD, Devalia JL, Davies RJ, Crook SJ, Tabaqchali S. | Br Med J (Clin Res Ed) | 10.1136/bmj.292.6524.857 | 1986 | |
| Enzymology | Evaluation of some methods for the laboratory identification of Haemophilus influenzae. | Tebbutt GM. | J Clin Pathol | 10.1136/jcp.36.9.991 | 1983 | |
| A comparative genetic study of serologically distinct Haemophilus influenzae type 1 immunoglobulin A1 proteases. | Poulsen K, Reinholdt J, Kilian M. | J Bacteriol | 10.1128/jb.174.9.2913-2921.1992 | 1992 | | |
| Enzymology | Antigenic heterogeneity of immunoglobulin A1 proteases from encapsulated and non-encapsulated Haemophilus influenzae. | Kilian M, Thomsen B. | Infect Immun | 10.1128/iai.42.1.126-132.1983 | 1983 | |
| Letter: No mouse model for H. influenzae infection. | Cargill JS, McKay SE. | J Clin Pathol | 10.1136/jcp.29.7.661 | 1976 | | |
| Enzymology | Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease. | Kilian M, Mestecky J, Schrohenloher RE. | Infect Immun | 10.1128/iai.26.1.143-149.1979 | 1979 | |
| Enzymology | Recombinant porin of Haemophilus influenzae type b. | Coulton JW, Chin AC, Vachon V | J Infect Dis | 10.1093/infdis/165-supplement_1-s188 | 1992 | |
| Pathogenicity | [Comparison of the growth curves of Escherichia coli and Haemophilus influenzae subjected to ampicillin and amoxicillin]. | Yourassowsky E, van der Linden MP, Lismont MJ, Crokaert F, Glupczynski Y | Pathol Biol (Paris) | 1985 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive11700.20260601.11
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BacDive in 2025: the core database for prokaryotic strain data
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