Bifidobacterium longum subsp. infantis CCUG 52486 is an anaerobe, mesophilic prokaryote that was isolated from Human feces,healthy elderly Italian individuals.
anaerobe mesophilic genome sequence| @ref 20215 |
Last LPSN update
2026-02-09 11:37:19 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Bifidobacteriales |
| Family Bifidobacteriaceae |
| Genus Bifidobacterium |
| Species Bifidobacterium longum subsp. infantis |
| Full scientific name Bifidobacterium longum subsp. infantis (Reuter 1963) Mattarelli et al. 2008 |
| Synonyms (1) |
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 97.9 |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68381 | 40585 ChEBI | alpha-cyclodextrin | - | builds acid from | from API rID32STR |
| 68380 | 29016 ChEBI | arginine | - | hydrolysis | from API rID32A |
| 68381 | 29016 ChEBI | arginine | - | hydrolysis | from API rID32STR |
| 68381 | 18333 ChEBI | D-arabitol | - | builds acid from | from API rID32STR |
| 68381 | 16899 ChEBI | D-mannitol | - | builds acid from | from API rID32STR |
| 68380 | 16024 ChEBI | D-mannose | - | fermentation | from API rID32A |
| 68381 | 16988 ChEBI | D-ribose | + | builds acid from | from API rID32STR |
| 68381 | 16443 ChEBI | D-tagatose | - | builds acid from | from API rID32STR |
| 68381 | 28087 ChEBI | glycogen | - | builds acid from | from API rID32STR |
| 68381 | 606565 ChEBI | hippurate | - | hydrolysis | from API rID32STR |
| 68381 | 30849 ChEBI | L-arabinose | - | builds acid from | from API rID32STR |
| 68380 | 29985 ChEBI | L-glutamate | - | degradation | from API rID32A |
| 68381 | 17716 ChEBI | lactose | + | builds acid from | from API rID32STR |
| 68381 | 17306 ChEBI | maltose | + | builds acid from | from API rID32STR |
| 68381 | 6731 ChEBI | melezitose | - | builds acid from | from API rID32STR |
| 68381 | 28053 ChEBI | melibiose | + | builds acid from | from API rID32STR |
| 68381 | 320055 ChEBI | methyl beta-D-glucopyranoside | - | builds acid from | from API rID32STR |
| 68380 | 17632 ChEBI | nitrate | - | reduction | from API rID32A |
| 68381 | 27941 ChEBI | pullulan | - | builds acid from | from API rID32STR |
| 68380 | 16634 ChEBI | raffinose | + | fermentation | from API rID32A |
| 68381 | 16634 ChEBI | raffinose | + | builds acid from | from API rID32STR |
| 68381 | 30911 ChEBI | sorbitol | - | builds acid from | from API rID32STR |
| 68381 | 17992 ChEBI | sucrose | + | builds acid from | from API rID32STR |
| 68381 | 27082 ChEBI | trehalose | + | builds acid from | from API rID32STR |
| 68380 | 27897 ChEBI | tryptophan | - | energy source | from API rID32A |
| 68380 | 16199 ChEBI | urea | - | hydrolysis | from API rID32A |
| 68381 | 16199 ChEBI | urea | - | hydrolysis | from API rID32STR |
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68381 | 15688 ChEBI | acetoin | from API rID32STR | |
| 68380 | 35581 ChEBI | indole | from API rID32A |
| @ref | Chebi-ID | Metabolite | Voges-proskauer-test | Indole test | |
|---|---|---|---|---|---|
| 68381 | 15688 ChEBI | acetoin | - | from API rID32STR | |
| 68380 | 35581 ChEBI | indole | - | from API rID32A |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68380 | alanine arylamidase | - | 3.4.11.2 | from API rID32A |
| 68381 | Alanyl-Phenylalanyl-Proline arylamidase | + | from API rID32STR | |
| 68380 | alkaline phosphatase | - | 3.1.3.1 | from API rID32A |
| 68381 | alkaline phosphatase | - | 3.1.3.1 | from API rID32STR |
| 68380 | alpha-arabinosidase | + | 3.2.1.55 | from API rID32A |
| 68380 | alpha-fucosidase | - | 3.2.1.51 | from API rID32A |
| 68381 | alpha-galactosidase | + | 3.2.1.22 | from API rID32STR |
| 68380 | alpha-galactosidase | + | 3.2.1.22 | from API rID32A |
| 68380 | alpha-glucosidase | + | 3.2.1.20 | from API rID32A |
| 68381 | arginine dihydrolase | - | 3.5.3.6 | from API rID32STR |
| 68380 | arginine dihydrolase | - | 3.5.3.6 | from API rID32A |
| 68381 | beta-galactosidase | + | 3.2.1.23 | from API rID32STR |
| 68380 | beta-galactosidase | + | 3.2.1.23 | from API rID32A |
| 68380 | beta-Galactosidase 6-phosphate | - | from API rID32A | |
| 68381 | beta-glucosidase | - | 3.2.1.21 | from API rID32STR |
| 68380 | beta-glucosidase | + | 3.2.1.21 | from API rID32A |
| 68381 | beta-glucuronidase | - | 3.2.1.31 | from API rID32STR |
| 68380 | beta-glucuronidase | - | 3.2.1.31 | from API rID32A |
| 68381 | beta-mannosidase | - | 3.2.1.25 | from API rID32STR |
| 68380 | glutamate decarboxylase | - | 4.1.1.15 | from API rID32A |
| 68380 | glutamyl-glutamate arylamidase | - | from API rID32A | |
| 68380 | glycin arylamidase | + | from API rID32A | |
| 68381 | glycyl tryptophan arylamidase | - | from API rID32STR | |
| 68380 | histidine arylamidase | + | from API rID32A | |
| 68380 | L-arginine arylamidase | + | from API rID32A | |
| 68380 | leucine arylamidase | + | 3.4.11.1 | from API rID32A |
| 68380 | leucyl glycin arylamidase | - | 3.4.11.1 | from API rID32A |
| 68381 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API rID32STR |
| 68380 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API rID32A |
| 68380 | phenylalanine arylamidase | + | from API rID32A | |
| 68380 | proline-arylamidase | + | 3.4.11.5 | from API rID32A |
| 68381 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API rID32STR |
| 68380 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API rID32A |
| 68380 | serine arylamidase | + | from API rID32A | |
| 68380 | tryptophan deaminase | - | 4.1.99.1 | from API rID32A |
| 68380 | tyrosine arylamidase | + | from API rID32A | |
| 68381 | urease | - | 3.5.1.5 | from API rID32STR |
| 68380 | urease | - | 3.5.1.5 | from API rID32A |
| @ref | ADH (Arg) | beta GLU | beta GAR | beta GUR | alpha GAL | PAL | RIB | MAN | SOR | LAC | TRE | RAF | SAC | LARA | DARL | Acid from alpha-cyclodextrinCDEX | Acetoin production (Voges Proskauer test)VP | Alanyl-Phenylalanyl-Proline arylamidaseAPPA | beta GAL | Pyrrolidonyl arylamidasePyrA | N-Acetyl-glucosaminidasebeta NAG | Glycyl-tryptophan arylamidaseGTA | HIP | GLYG | PUL | MAL | MEL | MLZ | Acidification of methyl beta-D-glucopyranosideMbeta DG | TAG | beta MAN | URE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 59567 | - | - | + | - | + | - | + | - | - | + | + | + | + | - | - | - | - | + | + | - | - | - | - | - | - | + | + | - | - | - | - | - |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM15541v1 assembly for Bifidobacterium longum subsp. infantis CCUG 52486 | scaffold | GCA_000155415   | 537937.5  | 643886216  | 537937 | 68.69 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Bifidobacterium exopolysaccharides: new insights into engineering strategies, physicochemical functions, and immunomodulatory effects on host health. | Sadeghi M, Haghshenas B, Nami Y. | Front Microbiol | 10.3389/fmicb.2024.1396308 | 2024 | | |
| Deciphering the Potential of Probiotics in Vaccines. | Xu C, Aqib AI, Fatima M, Muneer S, Zaheer T, Peng S, Ibrahim EH, Li K. | Vaccines (Basel) | 10.3390/vaccines12070711 | 2024 | | |
| Impact of Bifidobacterium longum Subspecies infantis on Pediatric Gut Health and Nutrition: Current Evidence and Future Directions. | Dargenio VN, Cristofori F, Brindicci VF, Schettini F, Dargenio C, Castellaneta SP, Iannone A, Francavilla R. | Nutrients | 10.3390/nu16203510 | 2024 | | |
| Genetics | Development of Real-Time PCR Assay to Specifically Detect 22 Bifidobacterium Species and Subspecies Using Comparative Genomics. | Kim HB, Kim E, Yang SM, Lee S, Kim MJ, Kim HY. | Front Microbiol | 10.3389/fmicb.2020.02087 | 2020 | |
| Impact of Diet and Lifestyle on Vaccine Efficacy in Adults Aged 55 and Older: A Review. | Hodges RE, Lamotte AV. | Integr Med (Encinitas) | 2022 | | ||
| Genetics | Targeted High-Resolution Taxonomic Identification of Bifidobacterium longum subsp. infantis Using Human Milk Oligosaccharide Metabolizing Genes. | Tso L, Bonham KS, Fishbein A, Rowland S, Klepac-Ceraj V. | Nutrients | 10.3390/nu13082833 | 2021 | |
| Phylogeny | Phylogenomic disentangling of the Bifidobacterium longum subsp. infantis taxon. | Tarracchini C, Milani C, Lugli GA, Mancabelli L, Fontana F, Alessandri G, Longhi G, Anzalone R, Viappiani A, Turroni F, van Sinderen D, Ventura M. | Microb Genom | 10.1099/mgen.0.000609 | 2021 | |
| Recent Development of Probiotic Bifidobacteria for Treating Human Diseases. | Chen J, Chen X, Ho CL. | Front Bioeng Biotechnol | 10.3389/fbioe.2021.770248 | 2021 | | |
| Gut Dysbiosis and Diabetic Foot Ulcer: Role of Probiotics. | Awasthi A, Corrie L, Vishwas S, Gulati M, Kumar B, Chellappan DK, Gupta G, Eri RD, Dua K, Singh SK. | Pharmaceutics | 10.3390/pharmaceutics14112543 | 2022 | | |
| Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486. | You J, Yaqoob P. | FEMS Immunol Med Microbiol | 10.1111/j.1574-695x.2012.01014.x | 2012 | | |
| Metabolism | Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial. | Przemska-Kosicka A, Childs CE, Maidens C, Dong H, Todd S, Gosney MA, Tuohy KM, Yaqoob P. | Front Immunol | 10.3389/fimmu.2018.00591 | 2018 | |
| Microbiological, chemical and rheological properties of low fat set yoghurt produced with exopolysaccharide (EPS) producing Bifidobacterium strains | Prasanna PHP, Grandison AS, Charalampopoulos D. | Food Res Int | 10.1016/j.foodres.2012.11.016 | 2013 | | |
| The aging gut microbiome and its impact on host immunity. | Bosco N, Noti M. | Genes Immun | 10.1038/s41435-021-00126-8 | 2021 | | |
| Evaluation of oil-in-water (O/W) emulsifying properties of galactan exopolysaccharide from Weissella confusa KR780676. | Kavitake D, Balyan S, Devi PB, Shetty PH. | J Food Sci Technol | 10.1007/s13197-020-04262-3 | 2020 | | |
| Effect of dairy-based protein sources and temperature on growth, acidification and exopolysaccharide production of Bifidobacterium strains in skim milk | Prasanna PHP, Grandison AS, Charalampopoulos D. | Food Res Int | 10.1016/j.foodres.2012.01.004 | 2012 | | |
| Screening human intestinal Bifidobacterium strains for growth, acidification, EPS production and viscosity potential in low-fat milk | Prasanna PHP, Grandison AS, Charalampopoulos D. | Int Dairy J | 10.1016/j.idairyj.2011.09.008 | 2012 | | |
| Immunoreactive Proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 Identified by Gnotobiotic Mono-Colonized Mice Sera, Immune Rabbit Sera and Non-immune Human Sera. | Gorska S, Dylus E, Rudawska A, Brzozowska E, Srutkova D, Schwarzer M, Razim A, Kozakova H, Gamian A. | Front Microbiol | 10.3389/fmicb.2016.01537 | 2016 | | |
| Probiotic modulation of dendritic cell function is influenced by ageing. | You J, Dong H, Mann ER, Knight SC, Yaqoob P. | Immunobiology | 10.1016/j.imbio.2013.08.012 | 2014 | | |
| Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial. | Enani S, Przemska-Kosicka A, Childs CE, Maidens C, Dong H, Conterno L, Tuohy K, Todd S, Gosney M, Yaqoob P. | Clin Nutr | 10.1016/j.clnu.2017.01.011 | 2018 | | |
| Quantitative Detection of Bifidobacterium longum Strains in Feces Using Strain-Specific Primers. | Xiao Y, Wang C, Zhao J, Zhang H, Chen W, Zhai Q. | Microorganisms | 10.3390/microorganisms9061159 | 2021 | | |
| Characterization and Exploitation of CRISPR Loci in Bifidobacterium longum. | Hidalgo-Cantabrana C, Crawley AB, Sanchez B, Barrangou R. | Front Microbiol | 10.3389/fmicb.2017.01851 | 2017 | | |
| Genetics | Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems. | O'Callaghan A, Bottacini F, O'Connell Motherway M, van Sinderen D. | BMC Genomics | 10.1186/s12864-015-1968-4 | 2015 | |
| Phylogeny | Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum. | Chaplin AV, Efimov BA, Smeianov VV, Kafarskaia LI, Pikina AP, Shkoporov AN. | PLoS One | 10.1371/journal.pone.0135658 | 2015 | |
| Enzymology | A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space. | Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney JA, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M. | Microbiome | 10.1186/s40168-018-0545-x | 2018 | |
| Comparative Genomics Revealed Genetic Diversity and Species/Strain-Level Differences in Carbohydrate Metabolism of Three Probiotic Bifidobacterial Species. | Odamaki T, Horigome A, Sugahara H, Hashikura N, Minami J, Xiao JZ, Abe F. | Int J Genomics | 10.1155/2015/567809 | 2015 | | |
| Exopolysaccharide Produced by Pediococcus pentosaceus E8: Structure, Bio-Activities, and Its Potential Application. | Jiang G, He J, Gan L, Li X, Xu Z, Yang L, Li R, Tian Y. | Front Microbiol | 10.3389/fmicb.2022.923522 | 2022 | | |
| Metabolism | Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization. | LoCascio RG, Desai P, Sela DA, Weimer B, Mills DA. | Appl Environ Microbiol | 10.1128/aem.00675-10 | 2010 | |
| Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods. | Linares DM, Gomez C, Renes E, Fresno JM, Tornadijo ME, Ross RP, Stanton C. | Front Microbiol | 10.3389/fmicb.2017.00846 | 2017 | | |
| Genetics | Comparative genomics of Bifidobacterium, Lactobacillus and related probiotic genera. | Lukjancenko O, Ussery DW, Wassenaar TM. | Microb Ecol | 10.1007/s00248-011-9948-y | 2012 | |
| Characterization of GH2 and GH42 beta-galactosidases derived from bifidobacterial infant isolates. | Ambrogi V, Bottacini F, O'Sullivan J, O'Connell Motherway M, Linqiu C, Schoemaker B, Schoterman M, van Sinderen D. | AMB Express | 10.1186/s13568-019-0735-3 | 2019 | | |
| Genetics | Tracking the Taxonomy of the Genus Bifidobacterium Based on a Phylogenomic Approach. | Lugli GA, Milani C, Duranti S, Mancabelli L, Mangifesta M, Turroni F, Viappiani A, van Sinderen D, Ventura M. | Appl Environ Microbiol | 10.1128/aem.02249-17 | 2018 | |
| Genetics | Comparative analyses of prophage-like elements present in bifidobacterial genomes. | Ventura M, Turroni F, Lima-Mendez G, Foroni E, Zomer A, Duranti S, Giubellini V, Bottacini F, Horvath P, Barrangou R, Sela DA, Mills DA, van Sinderen D. | Appl Environ Microbiol | 10.1128/aem.01112-09 | 2009 | |
| Pathogenicity | Insights into physiological and genetic mupirocin susceptibility in bifidobacteria. | Serafini F, Bottacini F, Viappiani A, Baruffini E, Turroni F, Foroni E, Lodi T, van Sinderen D, Ventura M. | Appl Environ Microbiol | 10.1128/aem.02540-10 | 2011 | |
| The effect of probiotics on respiratory tract infection with special emphasis on COVID-19: Systemic review 2010-20. | Darbandi A, Asadi A, Ghanavati R, Afifirad R, Darb Emamie A, Kakanj M, Talebi M. | Int J Infect Dis | 10.1016/j.ijid.2021.02.011 | 2021 | | |
| Metabolism | Metabolism of a plant derived galactose-containing polysaccharide by Bifidobacterium breve UCC2003. | O'Connell Motherway M, Fitzgerald GF, van Sinderen D. | Microb Biotechnol | 10.1111/j.1751-7915.2010.00218.x | 2011 | |
| Genetics | Genomic insights into bifidobacteria. | Lee JH, O'Sullivan DJ. | Microbiol Mol Biol Rev | 10.1128/mmbr.00004-10 | 2010 | |
| Metabolism | Emulsifying, rheological and physicochemical properties of exopolysaccharide produced by Bifidobacterium longum subsp. infantis CCUG 52486 and Bifidobacterium infantis NCIMB 702205. | Prasanna PH, Bell A, Grandison AS, Charalampopoulos D | Carbohydr Polym | 10.1016/j.carbpol.2012.05.075 | 2012 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive154129.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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