Bifidobacterium longum subsp. infantis (DSM 20088, ATCC 15697, NCTC 11817)

Name: Bifidobacterium longum subsp. infantis (DSM 20088, ATCC 15697, NCTC 11817)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 1743

Type strain

Strain Designation S12

Culture col. no. DSM 20088 ATCC 15697 NCTC 11817 S12 NCFB 2205 13 more

NCBI tax ID(s) 391904 1682

Special Collections DSMZ CCUG JCM KCTC CIP

History DSMZ <- G. Reuter, S12 JCM <-- ATCC 15697 <-- G. Reuter S12. CIP <- 1964, Lab. Ident., Inst. Pasteur, Paris, France, Bifidobacterium infantis, biotype V <- M. Sebald, Inst. Pasteur, Paris, France <- H. Werner <- G. Reuter: strain S12

Links

Bifidobacterium longum subsp. infantis S12 is an anaerobe, Gram-positive, rod-shaped bacterium that was isolated from intestine of infant.

Gram-positive rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 7401

LMG 8811,ATCC 15697,CCUG 18368,JCM 1222,LMG 10499,LMG 11046,NCFB 2205,NCTC 11817,LMG 13203,NBIMCC 8822,CCUG 30512,NCDO 2205,CCRC 14602,CCRC 15416,NCIMB 702205,CIP 64.67,CECT 4551,KCTC 3249,KCTC 3270,AS 1.1853,AS 1.2202,CCM 4990,NCAIM B.01821,BCRC 14602,BCRC 15416,HAMBI 1374,HAMBI 555,HAMBI 574,NRRL B-41661,DSM 20088,CGMCC 1.1853,CGMCC 1.2202,VTT E-97796,VTT E-021916,CCUG 30512 B

@ref 20215

Last LPSN update 2026-05-29 08:25:20

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Bifidobacteriales

Family Bifidobacteriaceae

Genus Bifidobacterium

Species Bifidobacterium longum subsp. infantis

Full scientific name Bifidobacterium longum subsp. infantis (Reuter 1963) Mattarelli et al. 2008

Synonyms (1)

Bifidobacterium infantis

BacDive ID	Other strains from **Bifidobacterium longum subsp. infantis** (24)	Type strain
1744	B. longum subsp. infantis S76E, DSM 20090, ATCC 15702, JCM 1272, BCRC ...
1745	B. longum subsp. infantis DSM 20218, ATCC 17930, JCM 1260, BCRC 14661
143274	B. longum subsp. infantis CCUG 18157, LMG 18912
146680	B. longum subsp. infantis CCUG 31778
148902	B. longum subsp. infantis CCUG 36569
151518	B. longum subsp. infantis CCUG 44191
152130	B. longum subsp. infantis CCUG 45868
152264	B. longum subsp. infantis CCUG 46247
152772	B. longum subsp. infantis CCUG 47592
154127	B. longum subsp. infantis CCUG 52484
154128	B. longum subsp. infantis CCUG 52485
154129	B. longum subsp. infantis CCUG 52486
154130	B. longum subsp. infantis CCUG 52487
155385	B. longum subsp. infantis CCUG 57566
159328	B. longum subsp. infantis WCA-178-WT-4B, DSM 107246
161155	B. longum subsp. infantis JCM 11344
161156	B. longum subsp. infantis JCM 11345
161157	B. longum subsp. infantis JCM 11347
161180	B. longum subsp. infantis JCM 11660, CGMCC 1.3006
161197	B. longum subsp. infantis JCM 1210, ATCC 25962, BCRC 14603, CECT 4552, ...
165449	B. longum subsp. infantis JCM 7007, LMG 18901
165450	B. longum subsp. infantis JCM 7009, LMG 18902
165451	B. longum subsp. infantis JCM 7010
165452	B. longum subsp. infantis JCM 7011

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
120651	positive	rod-shaped
125438				91.5

Colony morphology

120651

Hemolysis ability0

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
8514	BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)	Medium recipe at MediaDive	Name: BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58) Composition: Glucose 10.0 g/l Casein peptone 10.0 g/l Bacto Soytone 5.0 g/l Meat extract 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l MnSO4 x H2O 0.05 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Tween 80 Resazurin Distilled water
37702	MEDIUM 20 - for Anaerobic bacteria		Agar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)
120651	CIP Medium 20	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
8514	positive	growth	37
37702	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
8514	anaerobe
125439	obligate anaerobe	95.414

Spore formation

@ref	Spore formation	Confidence
125439		99.444

Murein

@ref	Murein short key	Type
8514	A21.03	A3ß L-Orn-L-Ser-L-Ala-L-Thr-L-Ala

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	+	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	+	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
120651	4853 ChEBI	esculin	-	hydrolysis
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	+	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	+	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	+	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
120651	17632 ChEBI	nitrate	-	reduction
120651	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	+	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
120651	35020 ChEBI	tributyrin	+	hydrolysis
68371	32528 ChEBI	turanose	+	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
120651	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
120651	amylase	-
68382	beta-galactosidase	+	3.2.1.23	from API zym
120651	beta-galactosidase	+	3.2.1.23
68382	beta-glucosidase	+	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
120651	caseinase	-	3.4.21.50
120651	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
120651	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
120651	gelatinase	-
120651	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
120651	lipase	-
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
120651	oxidase	-
120651	protease	-
68382	trypsin	-	3.4.21.4	from API zym
120651	tween esterase	-
120651	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
120651	-	-	+	+	-	+	-	-	-	-	+	+	+	+	-	+	+	+	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+	+	-	+	+	+	+	-	+/-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	-	-	-	+	+	-	+	+	+	+	-	-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	-	-	-	-	-	-	-	-	+	-	-	-	+	-	-	+	+	+	+	-	-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+	+	-	+	+	+	+	-	+/-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	-	+	+	-	+	+	+	+	-	+	-	+	-	+	-	-	+	-	-	-	+	-	-	-	-	-
8514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+/-	+	-	+	+	+	+	-	+	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	#Child
#Host Body-Site	#Gastrointestinal tract	-

Isolation

@ref	Sample type	Host species
8514	intestine of infant
67770	Intestine of infant
120651	Human, Infant, intestine	Homo sapiens

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8514	1	Risk group (German classification) According to TRBA 466
120651	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM2042v1 assembly for Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	complete	GCA_000020425	391904.5	643348516	391904	99.04
66792	ASM26996v1 assembly for Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	complete	GCA_000269965	391904.8	651053007	391904	98.96
66792	49888_B01 assembly for Bifidobacterium longum subsp. infantis NCTC11817	complete	GCA_900637215	1682.48	8116818856	1682	98.75
124043	ASM5190619v1 assembly for Bifidobacterium longum subsp. infantis CICC 6069 = ATCC 15697	contig	GCA_051906195			1682	63.67
67770	DSM-20088 assembly for Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	contig	GCA_000771105	391904.20	2657245662	391904	43.92

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Bifidobacterium longum subsp. infantis gene for 16S rRNA, partial sequence, strain: ATCC 15697	D86184	1515	391904
20218	Bifidobacterium longum subsp. infantis strain DSM 20088 16S ribosomal RNA gene, partial sequence	HQ012021	940	391904
20218	Bifidobacterium infantis (ATCC 15697) 16S ribosomal RNA gene, partial	M84783	642	1682
20218	Bifidobacterium infantis ATCC 15697 16S-23S intergenic spacer, partial sequence	U09792	477	391904
20218	B.infantis (CIP 6469) DNA sequence for 16S rRNA	X70974	1458	391904
20218	Bifidobacterium sp. 16S and 23S rRNA genes and ITS	X89111	2013	391904
67770	Bifidobacterium longum subsp. infantis gene for 16S ribosomal RNA, partial sequence, strain: JCM 1222	LC071820	1452	391904
67770	Bifidobacterium infantis 16S ribosomal RNA	M58738	1474	1682
124043	Bifidobacterium longum subsp. infantis gene for 16S ribosomal RNA, partial sequence, strain: YIT 12734.	AB924519	1492	1682
124043	Bifidobacterium longum subsp. infantis ATCC 15697 gene for 16S rRNA, partial sequence.	AB116305	472	391904

GC content

@ref	GC-content (mol%)	Method
8514	60.8
67770	60.8	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM2042v1 assembly for Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088
BV-BRC: 391904.5

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate anaerobe	95.41	no
125439	gram_stain	BacteriaNetⓘ	positive	46.04	no
125439	motility	BacteriaNetⓘ	no	80.06	no
125439	spore_formation	BacteriaNetⓘ	no	99.44	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ATCC 15697
NCBI: GCA_000020425.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	87.53	no
125438	anaerobic	anaerobicⓘ	yes	80.73	yes
125438	aerobic	aerobicⓘ	no	92.25	yes
125438	spore-forming	spore-formingⓘ	no	86.12	no
125438	thermophilic	thermophileⓘ	no	92.50	yes
125438	flagellated	motile2+ⓘ	no	91.50	no

Literature

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	Investigating the potential of yacon (Smallanthus sonchifolius) juice in the development of organic apple-based snacks.	Braschi G, Njieukam JA, Gottardi D, Genovese J, Tylewicz U, Patrignani F, Rocculi P.	Heliyon	10.1016/j.heliyon.2024.e32342	2024
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	Effects of different environmental stresses on cell surface hydrophobicity of lactobacilli, bifidobacteria and propionibacteria	Racioppo A, Accettulli A, d'Amelio A, Corbo M, Sinigaglia M, Speranza B, Bevilacqua A.	BMC Microbiol		2025
	Selection of yeasts and lactic acid bacteria to improve the nutritional quality, volatile profile, and biofunctional properties of chickpea flour.	Amadei S, Gandolfi I, Gottardi D, Cevoli C, D'Alessandro M, Siroli L, Lanciotti R, Patrignani F.	Curr Res Food Sci	10.1016/j.crfs.2025.101204	2025
	Ultrasound can increase biofilm formation by Lactiplantibacillus plantarum and Bifidobacterium spp.	Racioppo A, Speranza B, Altieri C, Sinigaglia M, Corbo MR, Bevilacqua A.	Front Microbiol	10.3389/fmicb.2023.1094671	2023
	The Effect of Human Milk Oligosaccharides and Bifidobacterium longum subspecies infantis Bi-26 on Simulated Infant Gut Microbiome and Metabolites.	Salli K, Hirvonen J, Anglenius H, Hibberd AA, Ahonen I, Saarinen MT, Maukonen J, Ouwehand AC.	Microorganisms	10.3390/microorganisms11061553	2023
	Bifidobacteria Strain Typing by Fourier Transform Infrared Spectroscopy.	Deidda F, Bozzi Cionci N, Cordovana M, Campedelli I, Fracchetti F, Di Gioia D, Ambretti S, Pane M.	Front Microbiol	10.3389/fmicb.2021.692975	2021
Genetics	Targeted High-Resolution Taxonomic Identification of Bifidobacterium longum subsp. infantis Using Human Milk Oligosaccharide Metabolizing Genes.	Tso L, Bonham KS, Fishbein A, Rowland S, Klepac-Ceraj V.	Nutrients	10.3390/nu13082833	2021
	How Do Prebiotics Affect Human Intestinal Bacteria?-Assessment of Bacterial Growth with Inulin and XOS In Vitro.	Schropp N, Stanislas V, Michels KB, Thriene K.	Int J Mol Sci	10.3390/ijms241612796	2023
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Metabolism	Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense.	Bunesova V, Lacroix C, Schwab C.	BMC Microbiol	10.1186/s12866-016-0867-4	2016
	Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota.	Chen YY, Zhao X, Moeder W, Tun HM, Simons E, Mandhane PJ, Moraes TJ, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL.	Microorganisms	10.3390/microorganisms9091847	2021
	Bifidobacterium beta-Glucosidase Activity and Fermentation of Dietary Plant Glucosides Is Species and Strain Specific.	Modrackova N, Vlkova E, Tejnecky V, Schwab C, Neuzil-Bunesova V.	Microorganisms	10.3390/microorganisms8060839	2020
Genetics	Systematically investigating and identifying bacteriocins in the human gut microbiome.	Zhang D, Zou Y, Shi Y, Zhang J, Liu J, Wu G, Zhang J, Gao Y, Chen M, Li YX.	Cell Genom	10.1016/j.xgen.2025.100983	2025
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	Swine Gut Lactic Acid Bacteria and Their Exopolysaccharides Differentially Modulate Toll-like Receptor Signaling Depending on the Agave Fructans Used as a Carbon Source.	Sanhueza-Carrera EA, Fernandez-Lainez C, Castro-De la Mora C, Ortega-Alvarez D, Mendoza-Camacho C, Cortez-Sanchez JM, Perez-Guille B, de Vos P, Lopez-Velazquez G.	Animals (Basel)	10.3390/ani15071047	2025
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	Biological Activity of an Epilobium angustifolium L. (Fireweed) Infusion after In Vitro Digestion.	Kowalik K, Polak-Berecka M, Prendecka-Wrobel M, Pigon-Zajac D, Niedzwiedz I, Szwajgier D, Baranowska-Wojcik E, Wasko A.	Molecules	10.3390/molecules27031006	2022
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	Antibodies to Lactobacilli and Bifidobacteria in young children with different propensity to develop islet autoimmunity.	Talja I, Kubo AL, Veijola R, Knip M, Simell O, Ilonen J, Vaha-Makila M, Sepp E, Mikelsaar M, Utt M, Uibo R.	J Immunol Res	10.1155/2014/325938	2014
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Genetics	Uncovering Bifidobacteria via Targeted Sequencing of the Mammalian Gut Microbiota.	Lugli GA, Duranti S, Milani C, Mancabelli L, Turroni F, Sinderen DV, Ventura M.	Microorganisms	10.3390/microorganisms7110535	2019
	Novel Fermented Plant-Based Functional Beverage: Biological Potential and Impact on the Human Gut Microbiota.	Vila-Real C, Costa C, Pimenta-Martins A, Mbugua S, Hagretou SL, Katina K, Maina NH, Pinto E, Gomes AMP.	Foods	10.3390/foods14030433	2025
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	A Combined Proteomics, Metabolomics and In Vivo Analysis Approach for the Characterization of Probiotics in Large-Scale Production.	Bianchi L, Laghi L, Correani V, Schifano E, Landi C, Uccelletti D, Mattei B.	Biomolecules	10.3390/biom10010157	2020
Genetics	Resource sharing of an infant gut microbiota synthetic community in combinations of human milk oligosaccharides.	Ioannou A, Berkhout MD, Scott WT, Blijenberg B, Boeren S, Mank M, Knol J, Belzer C.	ISME J	10.1093/ismejo/wrae209	2024
Metabolism	Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut.	Laursen MF, Sakanaka M, von Burg N, Morbe U, Andersen D, Moll JM, Pekmez CT, Rivollier A, Michaelsen KF, Molgaard C, Lind MV, Dragsted LO, Katayama T, Frandsen HL, Vinggaard AM, Bahl MI, Brix S, Agace W, Licht TR, Roager HM.	Nat Microbiol	10.1038/s41564-021-00970-4	2021
	Bifidobacteria support optimal infant vaccine responses.	Ryan FJ, Clarke M, Lynn MA, Benson SC, McAlister S, Giles LC, Choo JM, Rossouw C, Ng YY, Semchenko EA, Richard A, Leong LEX, Taylor SL, Blake SJ, Mugabushaka JI, Walker M, Wesselingh SL, Licciardi PV, Seib KL, Tumes DJ, Richmond P, Rogers GB, Marshall HS, Lynn DJ.	Nature	10.1038/s41586-025-08796-4	2025
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Metabolism	Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals.	Theilmann MC, Goh YJ, Nielsen KF, Klaenhammer TR, Barrangou R, Abou Hachem M.	mBio	10.1128/mbio.01421-17	2017
Pathogenicity	Acceptive Immunity: The Role of Fucosylated Glycans in Human Host-Microbiome Interactions.	Kononova S, Litvinova E, Vakhitov T, Skalinskaya M, Sitkin S.	Int J Mol Sci	10.3390/ijms22083854	2021
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Metabolism	Fecal microbiota transplantation results in bacterial strain displacement in patients with inflammatory bowel diseases.	Zou M, Jie Z, Cui B, Wang H, Feng Q, Zou Y, Zhang X, Yang H, Wang J, Zhang F, Jia H.	FEBS Open Bio	10.1002/2211-5463.12744	2020
Metabolism	Synthesis and fermentation properties of novel galacto-oligosaccharides by beta-galactosidases from Bifidobacterium species.	Rabiu BA, Jay AJ, Gibson GR, Rastall RA.	Appl Environ Microbiol	10.1128/aem.67.6.2526-2530.2001	2001
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Enzymology	New real-time quantitative PCR procedure for quantification of bifidobacteria in human fecal samples.	Gueimonde M, Tolkko S, Korpimaki T, Salminen S.	Appl Environ Microbiol	10.1128/aem.70.7.4165-4169.2004	2004
Metabolism	Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.	Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson MAE, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra S, Fardus-Reid F, Belteki G, McColl K, Swann JR, Kroll JS, Clarke P, Hall LJ.	Cell Rep Med	10.1016/j.xcrm.2020.100077	2020
Metabolism	Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.	von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, Jennemann R, Grone HJ, Mack M, Sandhoff R.	J Lipid Res	10.1194/jlr.d076190	2017
Metabolism	Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics.	Baranwal M, Clark RL, Thompson J, Sun Z, Hero AO, Venturelli OS.	Elife	10.7554/elife.73870	2022
Enzymology	Enterohepatic helicobacter in ulcerative colitis: potential pathogenic entities?	Thomson JM, Hansen R, Berry SH, Hope ME, Murray GI, Mukhopadhya I, McLean MH, Shen Z, Fox JG, El-Omar E, Hold GL.	PLoS One	10.1371/journal.pone.0017184	2011
	Indole Derivatives Biosynthesis in Bifidobacterium longum subsp. infantis and the Tryptophan Substrate Availability.	Zhang SM, Wu HC, Hung JH, Huang SL.	Microb Biotechnol	10.1111/1751-7915.70167	2025
Genetics	Scarless gene disruption enabled by a dual-plasmid knockout platform in a clinical infant-derived Bifidobacterium breve strain.	Gao Z, Feng L.	Front Microbiol	10.3389/fmicb.2025.1653505	2025
	Milk fat globule membrane protects Bifidobacterium longum ssp. infantis ATCC 15697 against bile stress by modifying global transcriptional responses.	Zhang G, He M, Xiao L, Jiao Y, Han J, Li C, Miller MJ, Zhang L.	J Dairy Sci	10.3168/jds.2023-23591	2024
	Effects of 2'-fucosyllactose on the viability of starter cultures and Bifidobacterium strains of human origin in yogurt during refrigerated storage.	Xie Z, Kim C, Miller MJ, Jin YS.	J Food Sci	10.1111/1750-3841.16996	2024
	Exploring bioactive compounds in chickpea and bean aquafaba: Insights from glycomics and peptidomics analyses.	Huang YP, Masarweh C, Paviani B, Mills DA, Barile D.	Food Chem	10.1016/j.foodchem.2024.140635	2024
	Protein-polysaccharide based double network microbeads improves stability of Bifidobacterium infantis ATCC 15697 in a gastro-Intestinal tract model (TIM-1).	Khan WA, Butt MS, Yasmin I, Wadood SA, Mahmood A, Gad HA.	Int J Pharm	10.1016/j.ijpharm.2024.123804	2024
	Research Progress on the Degradation of Human Milk Oligosaccharides (HMOs) by Bifidobacteria.	Cai R, Zhang J, Song Y, Liu X, Xu H.	Nutrients	10.3390/nu17030519	2025
	Impact of Bifidobacterium longum Subspecies infantis on Pediatric Gut Health and Nutrition: Current Evidence and Future Directions.	Dargenio VN, Cristofori F, Brindicci VF, Schettini F, Dargenio C, Castellaneta SP, Iannone A, Francavilla R.	Nutrients	10.3390/nu16203510	2024
	Therapeutic Potential of Bifidobacterium longum subsp. infantis B8762 on Gut and Respiratory Health in Infant.	Richmond RV, Mageswary U, Ali A, Taib F, Koo TH, Yusof A, Hamid IJA, Zhao F, Rahman NNNA, Hasan TH, Zhang H, Liong MT.	Int J Mol Sci	10.3390/ijms26031323	2025
	Characterization and stabilization of GluLm and its application to deglycosylate dietary flavonoids and lignans.	Curiel JA, de la Bastida AR, Langa S, Peiroten A, Landete JM.	Appl Microbiol Biotechnol	10.1007/s00253-023-12956-9	2024
	Isolation and Characterisation of Streptococcus spp. with Human Milk Oligosaccharides Utilization Capacity from Human Milk.	Zhou Y, Liu X, Chen H, Zhao J, Zhang H, Chen W, Yang B.	Foods	10.3390/foods13091291	2024
	Interactions between the human milk oligosaccharide 2'-fucosyllactose and Bifidobacterium longum subspecies infantis in influencing systemic immune development and function in piglets.	Daniels VC, Monaco MH, Hirvonen J, Ouwehand AC, Jensen HM, Mukerjea R, Christensen N, Lehtinen MJ, Dilger RN, Donovan SM.	Front Nutr	10.3389/fnut.2024.1444594	2024
Genetics	Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria.	Arzamasov AA, Rodionov DA, Hibberd MC, Guruge JL, Kent JE, Kazanov MD, Leyn SA, Elane ML, Sejane K, Furst A, Bode L, Barratt MJ, Gordon JI, Osterman AL.	Nat Microbiol	10.1038/s41564-025-02056-x	2025
Genetics	The Genome of Bifidobacterium longum subsp. infantis YLGB-1496 Provides Insights into Its Carbohydrate Utilization and Genetic Stability.	Li X, Yang J, Shi S, Lan H, Zhao W, Hung W, He J, Wang R.	Genes (Basel)	10.3390/genes15040466	2024
	Milk phospholipids protect Bifidobacterium longum subsp. infantis during in vitro digestion and enhance polysaccharide production.	Kosmerl E, Gonzalez-Orozco BD, Garcia-Cano I, Ortega-Anaya J, Jimenez-Flores R.	Front Nutr	10.3389/fnut.2023.1194945	2023
Pathogenicity	Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host.	Wasana WP, Waterland M, Everett DW, Thum C.	Microorganisms	10.3390/microorganisms13020223	2025
	Combining Bifidobacterium longum subsp. infantis and human milk oligosaccharides synergistically increases short chain fatty acid production ex vivo.	De Bruyn F, James K, Cottenet G, Dominick M, Katja J.	Commun Biol	10.1038/s42003-024-06628-1	2024
	Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides.	Gonzalez-Morelo KJ, Galan-Vasquez E, Melis F, Perez-Rueda E, Garrido D.	Front Mol Biosci	10.3389/fmolb.2023.1040721	2023
	Rapid discrimination of Bifidobacterium longum subspecies based on MALDI-TOF MS and machine learning.	Liu K, Wang Y, Zhao M, Xue G, Wang A, Wang W, Xu L, Chen J.	Front Microbiol	10.3389/fmicb.2023.1297451	2023
	Environmental factors drive bacterial degradation of gastrointestinal mucus.	Arias SL, van Wijngaarden EW, Balint D, Jones J, Crawford CC, Shukla PJ, Silberstein M, Brito IL.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00741-7	2025
Genetics	Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR.	Arzamasov AA, Nakajima A, Sakanaka M, Ojima MN, Katayama T, Rodionov DA, Osterman AL.	mSystems	10.1128/msystems.00343-22	2022
Metabolism	Genome-scale metabolic modeling of the human milk oligosaccharide utilization by Bifidobacterium longum subsp. infantis.	Roman L, Melis-Arcos F, Proschle T, Saa PA, Garrido D.	mSystems	10.1128/msystems.00715-23	2024
	Human milk oligosaccharides: bridging the gap in intestinal microbiota between mothers and infants.	Sun W, Tao L, Qian C, Xue PP, Du SS, Tao YN.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1386421	2024
	Generation of novel prebiotic oligosaccharide pools from fiber drives biological insight in bacterial glycan metabolism.	Masarweh C, Maldonado-Gomez M, Paviani B, Bhattacharya M, Weng C-Y, Suarez C, Ehlers-Cheang S, Stacy A, Castillo J, Krishnakumar N, Kalanetra KA, Barile D, German JB, Lebrilla CB, Mills DA.	Appl Environ Microbiol	10.1128/aem.02077-24	2025
	Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.	Kiely LJ, Busca K, Lane JA, van Sinderen D, Hickey RM.	FEMS Microbiol Rev	10.1093/femsre/fuad056	2023
Metabolism	Bifidobacterium infantis utilizes N-acetylglucosamine-containing human milk oligosaccharides as a nitrogen source.	Li S, You X, Rani A, Ozcan E, Sela DA.	Gut Microbes	10.1080/19490976.2023.2244721	2023
Enzymology	Structure and function of microbial alpha-l-fucosidases: a mini review.	Wu H, Owen CD, Juge N.	Essays Biochem	10.1042/ebc20220158	2023
Pathogenicity	The Yin and Yang of pathogens and probiotics: interplay between Salmonella enterica sv. Typhimurium and Bifidobacterium infantis during co-infection.	Shaw C, Weimer BC, Gann R, Desai PT, Shah JD.	Front Microbiol	10.3389/fmicb.2024.1387498	2024
	Abundance of Bifidobacterium species in the infant gut microbiota and associations with maternal-infant characteristics in Dhaka, Bangladesh.	Freitas AC, Li G, Shawon J, Qamar H, Pell LG, Kabir M, Oduaran OH, Puebla-Barragan S, Bassani DG, O'Callaghan KM, Onuora JC, Loutet MG, Heasley C, Starke CWE, Mahmud AA, Hamer DH, Pullenayegum E, Hossain MI, Siddiqui MM, Islam MS, Sherman PM, Shah PS, Gaffar SMA, Sultana S, Morris SK, Ahmed T, Haque R, Sarker SA, Roth DE.	mSphere	10.1128/msphere.00314-25	2025
	Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control.	Liu ZS, Chen PW.	Nutrients	10.3390/nu15122759	2023
	Rational Probiotic Strain Selection to Prevent Necrotizing Enterocolitis.	Preidis GA.	J Pediatr Gastroenterol Nutr	10.1097/mpg.0000000000003571	2022
	Delayed colonization of Bifidobacterium spp. and low prevalence of B. infantis among infants of Asian ancestry born in Singapore: insights from the GUSTO cohort study.	Xu J, Duar RM, Quah B, Gong M, Tin F, Chan P, Sim CK, Tan KH, Chong YS, Gluckman PD, Frese SA, Kyle D, Karnani N.	Front Pediatr	10.3389/fped.2024.1421051	2024
	Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides.	Ojima MN, Jiang L, Arzamasov AA, Yoshida K, Odamaki T, Xiao J, Nakajima A, Kitaoka M, Hirose J, Urashima T, Katoh T, Gotoh A, van Sinderen D, Rodionov DA, Osterman AL, Sakanaka M, Katayama T.	ISME J	10.1038/s41396-022-01270-3	2022
	Human milk oligosaccharides combine with Bifidobacterium longum to form the "golden shield" of the infant intestine: metabolic strategies, health effects, and mechanisms of action.	Yang S, Cai J, Su Q, Li Q, Meng X.	Gut Microbes	10.1080/19490976.2024.2430418	2024
Pathogenicity	Bifidobacterium longum subsp. longum BG-L47 boosts growth and activity of Limosilactobacillus reuteri DSM 17938 and its extracellular membrane vesicles.	Ermann Lundberg L, Pallabi Mishra P, Liu P, Forsberg MM, Sverremark-Ekstrom E, Grompone G, Hakansson S, Linninge C, Roos S.	Appl Environ Microbiol	10.1128/aem.00247-24	2024
	Regulatory mechanism of cysteine-dependent methionine biosynthesis in Bifidobacterium longum: insights into sulfur metabolism in gut microbiota.	Kim YT, Kwon JG, O'Sullivan DJ, Lee JH.	Gut Microbes	10.1080/19490976.2024.2419565	2024
	Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis (BiBga42A) revealed by crystallographic and mutational analyses.	Gotoh A, Hidaka M, Sakurama H, Nishimoto M, Kitaoka M, Sakanaka M, Fushinobu S, Katayama T.	Microbiome Res Rep	10.20517/mrr.2023.14	2023
Genetics	Milk glycan metabolism by intestinal bifidobacteria: insights from comparative genomics.	Arzamasov AA, Osterman AL.	Crit Rev Biochem Mol Biol	10.1080/10409238.2023.2182272	2022
	Screening of Bifidobacteria with Probiotic Potential from Healthy Infant Feces by Using 2'-Fucosyllactose.	Zhang G, Sun H, Xu Z, Tan Z, Xiao L, He M, Shang J, Tsapieva AN, Zhang L.	Foods	10.3390/foods12040858	2023
	Unveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach.	Jo SH, Jeon HJ, Song WS, Lee JS, Kwon JE, Park JH, Kim YR, Kim MG, Baek JH, Kwon SY, Kim JS, Yang YH, Kim YG.	Front Microbiol	10.3389/fmicb.2023.1293149	2023
	Comparative Genome Analysis of Bifidobacterium longum subsp. infantis Strains Reveals Variation in Human Milk Oligosaccharide Utilization Genes among Commercial Probiotics.	Duar RM, Casaburi G, Mitchell RD, Scofield LNC, Ortega Ramirez CA, Barile D, Henrick BM, Frese SA.	Nutrients	10.3390/nu12113247	2020
	Complete Genome Sequence of Bifidobacterium longum Strain Jih1, Isolated from Human Feces.	Inoue H, Shibata S, Ii K, Inoue J, Fukuda S, Arakawa K.	Microbiol Resour Announc	10.1128/mra.00319-20	2020
	Surface modification of probiotics at single-cell resolution: Strategies, applications, and future directions in inflammatory bowel disease.	Peng L, Wang X, Wang Y, Guo J, Yang J.	Mater Today Bio	10.1016/j.mtbio.2025.102485	2025
	A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism.	Schalich KM, Buendia MA, Kaur H, Choksi YA, Washington MK, Codreanu GS, Sherrod SD, McLean JA, Peek RM, Acra SA, Townsend SD, Yan F.	mBio	10.1128/mbio.00298-24	2024
Pathogenicity	Evaluation of 2'-Fucosyllactose and Bifidobacterium longum Subspecies infantis on Growth, Organ Weights, and Intestinal Development of Piglets.	Daniels VC, Monaco MH, Wang M, Hirvonen J, Jensen HM, Ouwehand AC, Mukherjea R, Dilger RN, Donovan SM.	Nutrients	10.3390/nu14010199	2021
	Safety, efficacy, and impact on gut microbial ecology of a Bifidobacterium longum subspecies infantis LMG11588 supplementation in healthy term infants: a randomized, double-blind, controlled trial in the Philippines.	Capeding MRZ, Phee LCM, Ming C, Noti M, Vidal K, Le Carrou G, Frezal A, Moll JM, Vogt JK, Myers PN, Nielsen BH, Boulange CL, Samuel TM, Berger B, Cercamondi CI.	Front Nutr	10.3389/fnut.2023.1319873	2023
	Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health.	Wong CB, Huang H, Ning Y, Xiao J.	Microorganisms	10.3390/microorganisms12051014	2024
Pathogenicity	Bifidobacterium longum Subspecies infantis (B. infantis) in Pediatric Nutrition: Current State of Knowledge.	Chichlowski M, Shah N, Wampler JL, Wu SS, Vanderhoof JA.	Nutrients	10.3390/nu12061581	2020
	The gut microbiota-brain connection: insights into major depressive disorder and bipolar disorder.	Zhao J, Liu J, Feng J, Liu X, Hu Q.	Front Psychiatry	10.3389/fpsyt.2024.1421490	2024
Metabolism	In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds.	Yun EJ, Yu S, Kim YA, Liu JJ, Kang NJ, Jin YS, Kim KH.	Mar Drugs	10.3390/md19040213	2021
	Bifidobacterium infantis Metabolizes 2'Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion.	Dedon LR, Ozcan E, Rani A, Sela DA.	Front Nutr	10.3389/fnut.2020.583397	2020
	Infant Fecal Fermentations with Galacto-Oligosaccharides and 2'-Fucosyllactose Show Differential Bifidobacterium longum Stimulation at Subspecies Level.	Lindner C, Looijesteijn E, Dijck HV, Bovee-Oudenhoven I, Heerikhuisen M, Broek TJVD, Marzorati M, Triantis V, Nauta A.	Children (Basel)	10.3390/children10030430	2023
Metabolism	Fucosylated Human Milk Oligosaccharide Foraging within the Species Bifidobacterium pseudocatenulatum Is Driven by Glycosyl Hydrolase Content and Specificity.	Shani G, Hoeflinger JL, Heiss BE, Masarweh CF, Larke JA, Jensen NM, Wickramasinghe S, Davis JC, Goonatilleke E, El-Hawiet A, Nguyen L, Klassen JS, Slupsky CM, Lebrilla CB, Mills DA.	Appl Environ Microbiol	10.1128/aem.01707-21	2022
	A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury.	Richards-Corke KC, Jiang Y, Yeliseyev V, Zhang Y, Franzosa EA, Wang ZA, Yapa Abeywardana M, Cole PA, Huttenhower C, Bry L, Balskus EP.	ACS Chem Biol	10.1021/acschembio.3c00556	2025
Metabolism	Metabolic and enzymatic elucidation of cooperative degradation of red seaweed agarose by two human gut bacteria.	Yun EJ, Yu S, Park NJ, Cho Y, Han NR, Jin YS, Kim KH.	Sci Rep	10.1038/s41598-021-92872-y	2021
	Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022.	Huang C, Hao W, Wang X, Zhou R, Lin Q.	Front Microbiol	10.3389/fmicb.2023.1211271	2023
Metabolism	Architecture Insight of Bifidobacterial alpha-L-Fucosidases.	Curiel JA, Peiroten A, Landete JM, Ruiz de la Bastida A, Langa S, Arques JL.	Int J Mol Sci	10.3390/ijms22168462	2021
Genetics	Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.	Schopping M, Vesth T, Jensen K, Franzen CJ, Zeidan AA.	Appl Environ Microbiol	10.1128/aem.02251-21	2022
Metabolism	Novel Genes and Metabolite Trends in Bifidobacterium longum subsp. infantis Bi-26 Metabolism of Human Milk Oligosaccharide 2'-fucosyllactose.	Zabel B, Yde CC, Roos P, Marcussen J, Jensen HM, Salli K, Hirvonen J, Ouwehand AC, Morovic W.	Sci Rep	10.1038/s41598-019-43780-9	2019
	Bifidobacterium exopolysaccharides: new insights into engineering strategies, physicochemical functions, and immunomodulatory effects on host health.	Sadeghi M, Haghshenas B, Nami Y.	Front Microbiol	10.3389/fmicb.2024.1396308	2024
Metabolism	tuf Gene Sequence Variation in Bifidobacterium longum subsp. infantis Detected in the Fecal Microbiota of Chinese Infants.	Lawley B, Centanni M, Watanabe J, Sims I, Carnachan S, Broadbent R, Lee PS, Wong KH, Tannock GW.	Appl Environ Microbiol	10.1128/aem.00336-18	2018
Pathogenicity	Anti-Campylobacter Probiotics: Latest Mechanistic Insights.	Balta I, Butucel E, Stef L, Pet I, Gradisteanu-Pircalabioru G, Chifiriuc C, Gundogdu O, McCleery D, Corcionivoschi N.	Foodborne Pathog Dis	10.1089/fpd.2022.0039	2022
Pathogenicity	Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics.	Idrees M, Imran M, Atiq N, Zahra R, Abid R, Alreshidi M, Roberts T, Abdelgadir A, Tipu MK, Farid A, Olawale OA, Ghazanfar S.	Front Nutr	10.3389/fnut.2022.959941	2022
	Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond.	Lordan C, Roche AK, Delsing D, Nauta A, Groeneveld A, MacSharry J, Cotter PD, van Sinderen D.	Microbiol Mol Biol Rev	10.1128/mmbr.00094-23	2024
Genetics	Microbial Glycoside Hydrolases in the First Year of Life: An Analysis Review on Their Presence and Importance in Infant Gut.	Ioannou A, Knol J, Belzer C.	Front Microbiol	10.3389/fmicb.2021.631282	2021
	HMO-primed bifidobacteria exhibit enhanced ability to adhere to intestinal epithelial cells.	Walsh C, Owens RA, Bottacini F, Lane JA, van Sinderen D, Hickey RM.	Front Microbiol	10.3389/fmicb.2023.1232173	2023
Genetics	Gene-trait matching among Bifidobacterium dentium strains reveals various glycan metabolism loci including a strain-specific fucosyllactose utilization cluster.	Catalano Gonzaga O, McKenna S, O'Neill I, Cotter PD, McAuliffe FM, Coffey A, van Sinderen D, Bottacini F.	Front Microbiol	10.3389/fmicb.2025.1584694	2025
	Immunoglobulin G from bovine milk primes intestinal epithelial cells for increased colonization of bifidobacteria.	Morrin ST, McCarthy G, Kennedy D, Marotta M, Irwin JA, Hickey RM.	AMB Express	10.1186/s13568-020-01048-w	2020
	Revisiting the Metabolic Capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a Glycoside Hydrolase Perspective.	Blanco G, Ruiz L, Tames H, Ruas-Madiedo P, Fdez-Riverola F, Sanchez B, Lourenco A, Margolles A.	Microorganisms	10.3390/microorganisms8050723	2020
	Loureirin A is a narrow-spectrum antimicrobial agent against Helicobacter pylori.	Tong Q, Yin C, Hang X, Bai Y, Zhang C, Xu J, Huang Y, Ge Y, Chen T, Zeng L, Jia J, Bi H.	Antimicrob Agents Chemother	10.1128/aac.00314-24	2024
Pathogenicity	Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology.	Ozcan E, Sela DA.	Front Nutr	10.3389/fnut.2018.00046	2018
	Preterm Infant Fecal Microbiota and Metabolite Profiles Are Modulated in a Probiotic Specific Manner.	Larke JA, Kuhn-Riordon K, Taft DH, Sohn K, Iqbal S, Underwood MA, Mills DA, Slupsky CM.	J Pediatr Gastroenterol Nutr	10.1097/mpg.0000000000003570	2022
Metabolism	Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum.	Duboux S, Golliard M, Muller JA, Bergonzelli G, Bolten CJ, Mercenier A, Kleerebezem M.	Sci Rep	10.1038/s41598-021-86740-y	2021
	Immobilization of a Bifidobacterial Endo-ß-N-Acetylglucosaminidase to Generate Bioactive Compounds for Food Industry.	Pekdemir B, Duman H, Arslan A, Kaplan M, Karyelioglu M, Ozer T, Kayili HM, Salih B, Henrick BM, Duar RM, Karav S.	Front Bioeng Biotechnol	10.3389/fbioe.2022.922423	2022
	Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood.	Vogel K, Arra A, Lingel H, Bretschneider D, Pratsch F, Schanze D, Zenker M, Balk S, Bruder D, Geffers R, Hachenberg T, Arens C, Brunner-Weinzierl MC.	Nat Commun	10.1038/s41467-023-41630-x	2023
	Early-life gut microbiome development and its potential long-term impact on health outcomes.	Borrego-Ruiz A, Borrego JJ.	Microbiome Res Rep	10.20517/mrr.2024.78	2025
	Health benefits, antimicrobial activities, and potential applications of probiotics: A review.	Sepehr A, Miri ST, Aghamohammad S, Rahimirad N, Milani M, Pourshafie MR, Rohani M.	Medicine (Baltimore)	10.1097/md.0000000000032412	2024
	Identifying single-strain growth patterns of human gut microbes in response to preterm human milk and formula.	Engevik MA, Stripe LK, Baatz JE, Wagner CL, Chetta KE.	Food Funct	10.1039/d2fo00447j	2022
	Potential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas.	Duman H, Kaplan M, Arslan A, Sahutoglu AS, Kayili HM, Frese SA, Karav S.	Front Nutr	10.3389/fnut.2021.646275	2021
	Characterizing the mucin-degrading capacity of the human gut microbiota.	Glover JS, Ticer TD, Engevik MA.	Sci Rep	10.1038/s41598-022-11819-z	2022
Genetics	Viability and Composition Validation of Commercial Probiotic Products by Selective Culturing Combined with Next-Generation Sequencing.	Ullah M, Raza A, Ye L, Yu Z.	Microorganisms	10.3390/microorganisms7070188	2019
Phylogeny	Influence of probiotic supplementation on the developing microbiota in human preterm neonates.	van Best N, Trepels-Kottek S, Savelkoul P, Orlikowsky T, Hornef MW, Penders J.	Gut Microbes	10.1080/19490976.2020.1826747	2020
	Preferential sugar utilization by bifidobacterial species.	Murakami R, Yoshida K, Sakanaka M, Urashima T, Xiao JZ, Katayama T, Odamaki T.	Microbiome Res Rep	10.20517/mrr.2023.19	2023
Phylogeny	Phylogenomic disentangling of the Bifidobacterium longum subsp. infantis taxon.	Tarracchini C, Milani C, Lugli GA, Mancabelli L, Fontana F, Alessandri G, Longhi G, Anzalone R, Viappiani A, Turroni F, van Sinderen D, Ventura M.	Microb Genom	10.1099/mgen.0.000609	2021
Genetics	A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.	Fricker AD, Sejane K, Desai M, Snyder MW, Duran L, Mackelprang R, Bode L, Ross MG, Flores GE.	Nutrients	10.3390/nu17020338	2025
	Cranberry Arabino-Xyloglucan and Pectic Oligosaccharides Induce Lactobacillus Growth and Short-Chain Fatty Acid Production.	Hotchkiss AT, Renye JA, White AK, Nunez A, Guron GKP, Chau H, Simon S, Poveda C, Walton G, Rastall R, Khoo C.	Microorganisms	10.3390/microorganisms10071346	2022
Metabolism	Stimulatory effects of novel glucosylated lactose derivatives GL34 on growth of selected gut bacteria.	Pham HTT, Boger MCL, Dijkhuizen L, Dijkhuizen L, van Leeuwen SS.	Appl Microbiol Biotechnol	10.1007/s00253-018-9473-8	2019
Metabolism	Esterases From Bifidobacteria Exhibit the Conversion of Albiflorin in Gut Microbiota.	Peng R, Han P, Fu J, Zhang ZW, Ma SR, Pan LB, Xia YY, Yu H, Xu H, Liu CX, Wang Y.	Front Microbiol	10.3389/fmicb.2022.880118	2022
Phylogeny	Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria.	Casaburi G, Duar RM, Vance DP, Mitchell R, Contreras L, Frese SA, Smilowitz JT, Underwood MA.	Antimicrob Resist Infect Control	10.1186/s13756-019-0583-6	2019
	The Impact of Bioactive Molecules from Probiotics on Child Health: A Comprehensive Review.	Guaman LP, Carrera-Pacheco SE, Zuniga-Miranda J, Teran E, Erazo C, Barba-Ostria C.	Nutrients	10.3390/nu16213706	2024
	Actively replicating gut bacteria identified by 5-ethynyl-2'-deoxyuridine (EdU) click chemistry and cell sorting.	Beauchemin ET, Hunter C, Maurice CF.	Gut Microbes	10.1080/19490976.2023.2180317	2023
	Maternal Intake of Probiotics to Program Offspring Health.	Cuinat C, Stinson SE, Ward WE, Comelli EM.	Curr Nutr Rep	10.1007/s13668-022-00429-w	2022
	Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome-Commensalism and Postbiotic Effects.	Jakobsen LMA, Maldonado-Gomez MX, Sundekilde UK, Andersen HJ, Nielsen DS, Bertram HC.	Metabolites	10.3390/metabo10040167	2020
	Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules.	Katoh T, Ojima MN, Sakanaka M, Ashida H, Gotoh A, Katayama T.	Microorganisms	10.3390/microorganisms8040481	2020
	Caenorhabditis Elegans and Probiotics Interactions from a Prolongevity Perspective.	Roselli M, Schifano E, Guantario B, Zinno P, Uccelletti D, Devirgiliis C.	Int J Mol Sci	10.3390/ijms20205020	2019
Phylogeny	Human Milk Oligosaccharide-Stimulated Bifidobacterium Species Contribute to Prevent Later Respiratory Tract Infections.	Dogra SK, Martin FP, Donnicola D, Julita M, Berger B, Sprenger N.	Microorganisms	10.3390/microorganisms9091939	2021
	Two-Stage Interpretation of Changes in TEER of Intestinal Epithelial Layers Protected by Adhering Bifidobacteria During E. coli Challenges.	Yuan L, van der Mei HC, Busscher HJ, Peterson BW.	Front Microbiol	10.3389/fmicb.2020.599555	2020
Pathogenicity	Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity.	Beverly RL, Woonnimani P, Scottoline BP, Lueangsakulthai J, Dallas DC.	Int J Mol Sci	10.3390/ijms22052377	2021
	Appraisal of postbiotics in cancer therapy.	Sudaarsan ASK, Ghosh AR.	Front Pharmacol	10.3389/fphar.2024.1436021	2024
	Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition.	Barratt MJ, Nuzhat S, Ahsan K, Frese SA, Arzamasov AA, Sarker SA, Islam MM, Palit P, Islam MR, Hibberd MC, Hibberd MC, Nakshatri S, Cowardin CA, Guruge JL, Byrne AE, Venkatesh S, Sundaresan V, Henrick B, Duar RM, Mitchell RD, Casaburi G, Prambs J, Flannery R, Mahfuz M, Rodionov DA, Osterman AL, Kyle D, Ahmed T, Gordon JI.	Sci Transl Med	10.1126/scitranslmed.abk1107	2022
	Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition.	Duman H, Bechelany M, Karav S.	Nutrients	10.3390/nu17010118	2024
	Effects of Different Human Milk Oligosaccharides on Growth of Bifidobacteria in Monoculture and Co-culture With Faecalibacterium prausnitzii.	Cheng L, Kiewiet MBG, Logtenberg MJ, Groeneveld A, Nauta A, Schols HA, Walvoort MTC, Harmsen HJM, de Vos P.	Front Microbiol	10.3389/fmicb.2020.569700	2020
	Treg-inducing capacity of genomic DNA of Bifidobacterium longum subsp. infantis.	Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, Lawless OJ, Tallon L, Sadzewicz L, Calderone R, Bellanti JA.	Allergy Asthma Proc	10.2500/aap.2020.41.200064	2020
	Engineered plants provide a photosynthetic platform for the production of diverse human milk oligosaccharides.	Barnum CR, Paviani B, Couture G, Masarweh C, Chen Y, Huang YP, Markel K, Mills DA, Lebrilla CB, Barile D, Yang M, Shih PM.	Nat Food	10.1038/s43016-024-00996-x	2024
	Bifidobacterium infantis associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice.	Nyangahu DD, Happel AU, Wendoh J, Kiravu A, Wang Y, Feng C, Plumlee C, Cohen S, Brown BP, Djukovic D, Ganief T, Gasper M, Raftery D, Blackburn JM, Allbritton NL, Gray CM, Paik J, Urdahl KB, Jaspan HB.	Sci Adv	10.1126/sciadv.ade1370	2023
Metabolism	Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism.	Acquistapace IM, Zi Etek MA, Li AWH, Salmon M, Kuhn I, Bedford MR, Brearley CA, Hemmings AM.	J Biol Chem	10.1074/jbc.ra120.015925	2020
	The therapeutic value of bifidobacteria in cardiovascular disease.	Tang J, Wei Y, Pi C, Zheng W, Zuo Y, Shi P, Chen J, Xiong L, Chen T, Liu H, Zhao Q, Yin S, Ren W, Cao P, Zeng N, Zhao L.	NPJ Biofilms Microbiomes	10.1038/s41522-023-00448-7	2023
Biotechnology	A Human Gut Commensal Ferments Cranberry Carbohydrates To Produce Formate.	Ozcan E, Sun J, Rowley DC, Sela DA.	Appl Environ Microbiol	10.1128/aem.01097-17	2017
Metabolism	Bifidobacteria grown on human milk oligosaccharides downregulate the expression of inflammation-related genes in Caco-2 cells.	Wickramasinghe S, Pacheco AR, Lemay DG, Mills DA.	BMC Microbiol	10.1186/s12866-015-0508-3	2015
Metabolism	Milk Glycans and Their Interaction with the Infant-Gut Microbiota.	Kirmiz N, Robinson RC, Shah IM, Barile D, Mills DA.	Annu Rev Food Sci Technol	10.1146/annurev-food-030216-030207	2018
	The role of gut microbiota in liver regeneration.	Xu Z, Jiang N, Xiao Y, Yuan K, Wang Z.	Front Immunol	10.3389/fimmu.2022.1003376	2022
	Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro.	Gelli HP, Vazquez-Uribe R, Sommer MOA.	Front Pharmacol	10.3389/fphar.2022.1049324	2022
	Microbes as medicine.	Daisley BA, Allen-Vercoe E.	Ann N Y Acad Sci	10.1111/nyas.15237	2024
	Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial.	Rao S, Esvaran M, Chen L, Keil AD, Gollow I, Simmer K, Wemheuer B, Conway P, Patole S.	Pediatr Res	10.1038/s41390-021-01884-x	2022
	Cross-feeding interactions between human gut commensals belonging to the Bacteroides and Bifidobacterium genera when grown on dietary glycans.	Fernandez-Julia P, Commane DM, van Sinderen D, Munoz-Munoz J.	Microbiome Res Rep	10.20517/mrr.2021.05	2022
	Immunoreactive Proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 Identified by Gnotobiotic Mono-Colonized Mice Sera, Immune Rabbit Sera and Non-immune Human Sera.	Gorska S, Dylus E, Rudawska A, Brzozowska E, Srutkova D, Schwarzer M, Razim A, Kozakova H, Gamian A.	Front Microbiol	10.3389/fmicb.2016.01537	2016
Metabolism	Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI.	Kim MJ, Ku S, Kim SY, Lee HH, Jin H, Kang S, Li R, Johnston TV, Park MS, Ji GE.	Int J Mol Sci	10.3390/ijms19051422	2018
	Term Infant Formulas Influencing Gut Microbiota: An Overview.	Fabiano V, Indrio F, Verduci E, Calcaterra V, Pop TL, Mari A, Zuccotti GV, Cullu Cokugras F, Pettoello-Mantovani M, Goulet O.	Nutrients	10.3390/nu13124200	2021
Pathogenicity	The gut-immune-brain axis in neurodevelopment and neurological disorders.	Park JC, Im SH.	Microbiome Res Rep	10.20517/mrr.2022.11	2022
Metabolism	A novel gene cluster allows preferential utilization of fucosylated milk oligosaccharides in Bifidobacterium longum subsp. longum SC596.	Garrido D, Ruiz-Moyano S, Kirmiz N, Davis JC, Totten SM, Lemay DG, Ugalde JA, German JB, Lebrilla CB, Mills DA.	Sci Rep	10.1038/srep35045	2016
Phylogeny	Comparison of various molecular methods for rapid differentiation of intestinal bifidobacteria at the species, subspecies and strain level.	Jarocki P, Podlesny M, Komon-Janczara E, Kucharska J, Glibowska A, Targonski Z.	BMC Microbiol	10.1186/s12866-016-0779-3	2016
	Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease-An Overview.	Lopes SA, Roque-Borda CA, Duarte JL, Di Filippo LD, Borges Cardoso VM, Pavan FR, Chorilli M, Meneguin AB.	Pharmaceutics	10.3390/pharmaceutics15112600	2023
	The interplay between probiotics and host autophagy: mechanisms of action and emerging insights.	Sadeghloo Z, Nabavi-Rad A, Zali MR, Klionsky DJ, Yadegar A.	Autophagy	10.1080/15548627.2024.2403277	2025
Genetics	Comparative Genomics Analyses Reveal the Differences between B. longum subsp. infantis and B. longum subsp. longum in Carbohydrate Utilisation, CRISPR-Cas Systems and Bacteriocin Operons.	Li M, Zhou X, Stanton C, Ross RP, Zhao J, Zhang H, Yang B, Chen W.	Microorganisms	10.3390/microorganisms9081713	2021
Genetics	Mobilome and Resistome Reconstruction from Genomes Belonging to Members of the Bifidobacterium Genus.	Mancino W, Lugli GA, Sinderen DV, Ventura M, Turroni F.	Microorganisms	10.3390/microorganisms7120638	2019
Metabolism	Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes.	Fushinobu S, Abou Hachem M.	Biochem Soc Trans	10.1042/bst20200163	2021
	Exploring the sequence-function space of microbial fucosidases.	Martinez Gascuena A, Wu H, Wang R, Owen CD, Hernando PJ, Monaco S, Penner M, Xing K, Le Gall G, Gardner R, Ndeh D, Urbanowicz PA, Spencer DIR, Walsh M, Angulo J, Juge N.	Commun Chem	10.1038/s42004-024-01212-4	2024
	Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling.	Lui O, Dridi L, Gonzalez E, Yasmine S, Kubinski R, Billings H, Bohlmann J, Withers SG, Maurice C, Castagner B.	ACS Chem Biol	10.1021/acschembio.2c00791	2023
	Characterization of GH2 and GH42 beta-galactosidases derived from bifidobacterial infant isolates.	Ambrogi V, Bottacini F, O'Sullivan J, O'Connell Motherway M, Linqiu C, Schoemaker B, Schoterman M, van Sinderen D.	AMB Express	10.1186/s13568-019-0735-3	2019
Metabolism	Complete genome sequence of Bifidobacterium longum JDM301.	Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, Zhao GP, Wang S, Guo XK.	J Bacteriol	10.1128/jb.00538-10	2010
Metabolism	Detection of galectin-3 interaction with commensal bacteria.	Kavanaugh D, Kane M, Joshi L, Hickey RM.	Appl Environ Microbiol	10.1128/aem.03694-12	2013
	Effect of catechins on the growth of oxygen-sensitive probiotic bacteria	Gaudreau H, Champagne CP, Remondetto GE, Bazinet L, Subirade M.	Food Res Int	10.1016/j.foodres.2012.10.014	2013
	Human Milk Oligosaccharides: The Journey Ahead.	Ray C, Kerketta JA, Rao S, Patel S, Dutt S, Arora K, Pournami F, Bhushan P.	Int J Pediatr	10.1155/2019/2390240	2019
Metabolism	Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways.	Engevik MA, Luk B, Chang-Graham AL, Hall A, Herrmann B, Ruan W, Endres BT, Shi Z, Garey KW, Hyser JM, Versalovic J.	mBio	10.1128/mbio.01087-19	2019
Phylogeny	Identification of species belonging to the Bifidobacterium genus by PCR-RFLP analysis of a hsp60 gene fragment.	Baffoni L, Stenico V, Strahsburger E, Gaggia F, Di Gioia D, Modesto M, Mattarelli P, Biavati B.	BMC Microbiol	10.1186/1471-2180-13-149	2013
Metabolism	Inulin Fermentation by Lactobacilli and Bifidobacteria from Dairy Calves.	Zhu Y, Liu J, Lopez JM, Mills DA.	Appl Environ Microbiol	10.1128/aem.01738-20	2020
Genetics	Infant Gut Microbial Metagenome Mining of alpha-l-Fucosidases with Activity on Fucosylated Human Milk Oligosaccharides and Glycoconjugates.	Moya-Gonzalvez EM, Pena-Gil N, Rubio-Del-Campo A, Coll-Marques JM, Gozalbo-Rovira R, Monedero V, Rodriguez-Diaz J, Yebra MJ.	Microbiol Spectr	10.1128/spectrum.01775-22	2022
	New Functional Foods with Cactus Components: Sustainable Perspectives and Future Trends.	Monteiro SS, Almeida RL, Santos NC, Pereira EM, Silva AP, Oliveira HML, Pasquali MAB.	Foods	10.3390/foods12132494	2023
Pathogenicity	Health benefits conferred by the human gut microbiota during infancy.	Ventura M, Milani C, Lugli GA, van Sinderen D.	Microb Biotechnol	10.1111/1751-7915.13334	2019
Enzymology	2-oxoglutarate:acceptor oxidoreductase-catalyzed redox cycling effectively targets coccoid forms of Helicobacter pylori.	Hang X, Lan W, Yanqiang H, Huang H, Zhang M, Zeng L, Shi T, Bai Y, Yang Z, Hu S, Wang J, Dong L, Tong Q, Jia J, Bi S, Xia Q, Gao Y, Bi H.	Nat Commun	10.1038/s41467-025-62477-4	2025
	A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome.	Zeng S, Patangia D, Almeida A, Zhou Z, Mu D, Paul Ross R, Stanton C, Wang S.	Nat Commun	10.1038/s41467-022-32805-z	2022
Enzymology	A new insight into the physiological role of bile salt hydrolase among intestinal bacteria from the genus Bifidobacterium.	Jarocki P, Podlesny M, Glibowski P, Targonski Z.	PLoS One	10.1371/journal.pone.0114379	2014
	Molecular Insights Into O-Linked Glycan Utilization by Gut Microbes.	Gonzalez-Morelo KJ, Vega-Sagardia M, Garrido D.	Front Microbiol	10.3389/fmicb.2020.591568	2020
Metabolism	Variation in consumption of human milk oligosaccharides by infant gut-associated strains of Bifidobacterium breve.	Ruiz-Moyano S, Totten SM, Garrido DA, Smilowitz JT, German JB, Lebrilla CB, Mills DA.	Appl Environ Microbiol	10.1128/aem.01843-13	2013
	Differentiation of Bifidobacterium longum subspecies longum and infantis by quantitative PCR using functional gene targets.	Lawley B, Munro K, Hughes A, Hodgkinson AJ, Prosser CG, Lowry D, Zhou SJ, Makrides M, Gibson RA, Lay C, Chew C, Lee PS, Wong KH, Tannock GW.	PeerJ	10.7717/peerj.3375	2017
	Utilization of Host-Derived Glycans by Intestinal Lactobacillus and Bifidobacterium Species.	Zuniga M, Monedero V, Yebra MJ.	Front Microbiol	10.3389/fmicb.2018.01917	2018
	Beyond Metabolism: The Complex Interplay Between Dietary Phytoestrogens, Gut Bacteria, and Cells of Nervous and Immune Systems.	Cady N, Peterson SR, Freedman SN, Mangalam AK.	Front Neurol	10.3389/fneur.2020.00150	2020
Metabolism	Physical and Functional Interplay between MazF₁^Bif and Its Noncognate Antitoxins from Bifidobacterium longum.	Wei Y, Li Y, Yang F, Wu Q, Liu D, Li X, Hua H, Liu X, Wang Y, Zheng K, Tang R.	Appl Environ Microbiol	10.1128/aem.03232-16	2017
Enzymology	The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates alpha1-2-fucosyltransferase.	Zhao C, Wu Y, Yu H, Shah IM, Li Y, Zeng J, Liu B, Mills DA, Chen X.	Chem Commun (Camb)	10.1039/c5cc10646j	2016
Genetics	Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems.	O'Callaghan A, Bottacini F, O'Connell Motherway M, van Sinderen D.	BMC Genomics	10.1186/s12864-015-1968-4	2015
	Characterization and Exploitation of CRISPR Loci in Bifidobacterium longum.	Hidalgo-Cantabrana C, Crawley AB, Sanchez B, Barrangou R.	Front Microbiol	10.3389/fmicb.2017.01851	2017
Metabolism	Proteomic analysis of Bifidobacterium longum subsp. infantis reveals the metabolic insight on consumption of prebiotics and host glycans.	Kim JH, An HJ, Garrido D, German JB, Lebrilla CB, Mills DA.	PLoS One	10.1371/journal.pone.0057535	2013
	alpha-L-Fucosidases from an Alpaca Faeces Metagenome: Characterisation of Hydrolytic and Transfucosylation Potential.	Krupinskaite A, Stanislauskiene R, Serapinas P, Rutkiene R, Gasparaviciute R, Meskys R, Stankeviciute J.	Int J Mol Sci	10.3390/ijms25020809	2024
	Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells.	Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, Lebrilla CB, Stephensen CB, Mills DA, Raybould HE.	BMC Microbiol	10.1186/s12866-020-02023-y	2020
Metabolism	Bovine milk oligosaccharides decrease gut permeability and improve inflammation and microbial dysbiosis in diet-induced obese mice.	Boudry G, Hamilton MK, Chichlowski M, Wickramasinghe S, Barile D, Kalanetra KM, Mills DA, Raybould HE.	J Dairy Sci	10.3168/jds.2016-11890	2017
Metabolism	The effect of calcium palmitate on bacteria associated with infant gut microbiota.	Wang L, Bravo-Ruiseco G, Happe R, He T, van Dijl JM, Harmsen HJM.	Microbiologyopen	10.1002/mbo3.1187	2021
Genetics	Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian.	Hao Y, Huang D, Guo H, Xiao M, An H, Zhao L, Zuo F, Zhang B, Hu S, Song S, Chen S, Ren F.	J Bacteriol	10.1128/jb.01213-10	2011
	Validating bifidobacterial species and subspecies identity in commercial probiotic products.	Lewis ZT, Shani G, Masarweh CF, Popovic M, Frese SA, Sela DA, Underwood MA, Mills DA.	Pediatr Res	10.1038/pr.2015.244	2016
Pathogenicity	Structure and Function of Bovine Whey Derived Oligosaccharides Showing Synbiotic Epithelial Barrier Protective Properties.	Duncan PI, Aitio O, Heiskanen A, Niemela R, Saarinen J, Helin J, Porta N, Fiaux M, Moennoz D, Golliard M, Cherbut C, Berrocal R, Austin S, Sprenger N.	Nutrients	10.3390/nu12072007	2020
	Protein-Linked Glycan Degradation in Infants Fed Human Milk.	Dallas DC, Sela D, Underwood MA, German JB, Lebrilla C.	J Glycomics Lipidomics	10.4172/2153-0637.s1-002	2012
Metabolism	Endo-beta-N-acetylglucosaminidases from infant gut-associated bifidobacteria release complex N-glycans from human milk glycoproteins.	Garrido D, Nwosu C, Ruiz-Moyano S, Aldredge D, German JB, Lebrilla CB, Mills DA.	Mol Cell Proteomics	10.1074/mcp.m112.018119	2012
	How microbial glycosyl hydrolase activity in the gut mucosa initiates microbial cross-feeding.	Berkhout MD, Plugge CM, Belzer C.	Glycobiology	10.1093/glycob/cwab105	2022
	The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins.	Poluektova E, Yunes R, Danilenko V.	Nutrients	10.3390/nu13051591	2021
Genetics	Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan.	Odamaki T, Bottacini F, Kato K, Mitsuyama E, Yoshida K, Horigome A, Xiao JZ, van Sinderen D.	Sci Rep	10.1038/s41598-017-18391-x	2018
Phylogeny	Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics.	Lugli GA, Milani C, Turroni F, Duranti S, Ferrario C, Viappiani A, Mancabelli L, Mangifesta M, Taminiau B, Delcenserie V, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02004-14	2014
Metabolism	Oligosaccharide binding proteins from Bifidobacterium longum subsp. infantis reveal a preference for host glycans.	Garrido D, Kim JH, German JB, Raybould HE, Mills DA.	PLoS One	10.1371/journal.pone.0017315	2011
	Modulation of the Gut Microbiota by Tomato Flours Obtained after Conventional and Ohmic Heating Extraction and Its Prebiotic Properties.	Coelho MC, Costa C, Roupar D, Silva S, Rodrigues AS, Teixeira JA, Pintado ME.	Foods	10.3390/foods12091920	2023
Pathogenicity	Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet.	Dahlin M, Singleton SS, David JA, Basuchoudhary A, Wickstrom R, Mazumder R, Prast-Nielsen S.	EBioMedicine	10.1016/j.ebiom.2022.104061	2022
	The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition.	Hegar B, Wibowo Y, Basrowi RW, Ranuh RG, Sudarmo SM, Munasir Z, Atthiyah AF, Widodo AD, Supriatmo, Kadim M, Suryawan A, Diana NR, Manoppo C, Vandenplas Y.	Pediatr Gastroenterol Hepatol Nutr	10.5223/pghn.2019.22.4.330	2019
Phylogeny	Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum.	Chaplin AV, Efimov BA, Smeianov VV, Kafarskaia LI, Pikina AP, Shkoporov AN.	PLoS One	10.1371/journal.pone.0135658	2015
Pathogenicity	Common Oral Medications Lead to Prophage Induction in Bacterial Isolates from the Human Gut.	Sutcliffe SG, Shamash M, Hynes AP, Maurice CF.	Viruses	10.3390/v13030455	2021
	Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.	Powell WT, Borghese RA, Kalanetra KM, Mirmiran M, Mills DA, Underwood MA.	J Pediatr Gastroenterol Nutr	10.1097/mpg.0000000000001031	2016
	Transcription analysis of a lantibiotic gene cluster from Bifidobacterium longum DJO10A.	Lee JH, Li X, O'Sullivan DJ.	Appl Environ Microbiol	10.1128/aem.00571-11	2011
Metabolism	Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome.	Lee MT, Le HH, Johnson EL.	J Lipid Res	10.1194/jlr.ra120000950	2021
Metabolism	Kinetic characterization of a novel endo-beta-N-acetylglucosaminidase on concentrated bovine colostrum whey to release bioactive glycans.	Karav S, Parc AL, de Moura Bell JM, Rouquie C, Mills DA, Barile D, Block DE.	Enzyme Microb Technol	10.1016/j.enzmictec.2015.05.007	2015
	Characterization of immunostimulatory CpG-rich sequences from different Bifidobacterium species.	Menard O, Gafa V, Kapel N, Rodriguez B, Butel MJ, Waligora-Dupriet AJ.	Appl Environ Microbiol	10.1128/aem.01714-09	2010
	Neutral and Pectic Heteropolysaccharides Isolated from Opuntia joconostle Mucilage: Composition, Molecular Dimensions and Prebiotic Potential.	Cruz-Rubio JM, Riva A, Cybulska J, Zdunek A, Berry D, Loeppert R, Viernstein H, Praznik W, Maghuly F.	Int J Mol Sci	10.3390/ijms24043208	2023
	Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes-Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy.	Ferreira G, Vieira P, Alves A, Nunes S, Preguica I, Martins-Marques T, Ribeiro T, Girao H, Figueirinha A, Salgueiro L, Pintado M, Gomes P, Viana S, Reis F.	Nutrients	10.3390/nu16040513	2024
Metabolism	Biochemical Characterization and Complete Conversion of Coenzyme Specificity of Isocitrate Dehydrogenase from Bifidobacterium longum.	Huang SP, Cheng HM, Wang P, Zhu GP.	Int J Mol Sci	10.3390/ijms17030296	2016
	Prebiotic Potential and Chemical Composition of Seven Culinary Spice Extracts.	Lu QY, Summanen PH, Lee RP, Huang J, Henning SM, Heber D, Finegold SM, Li Z.	J Food Sci	10.1111/1750-3841.13792	2017
Metabolism	Diversity, ecology and intestinal function of bifidobacteria.	Bottacini F, Ventura M, van Sinderen D, O'Connell Motherway M.	Microb Cell Fact	10.1186/1475-2859-13-s1-s4	2014
Metabolism	Glycoprofiling bifidobacterial consumption of galacto-oligosaccharides by mass spectrometry reveals strain-specific, preferential consumption of glycans.	Barboza M, Sela DA, Pirim C, Locascio RG, Freeman SL, German JB, Mills DA, Lebrilla CB.	Appl Environ Microbiol	10.1128/aem.00842-09	2009
Genetics	Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.	Vatanen T, Plichta DR, Somani J, Munch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajarvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lahdesmaki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.	Nat Microbiol	10.1038/s41564-018-0321-5	2019
Metabolism	Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis.	Fang J, Wang H, Zhou Y, Zhang H, Zhou H, Zhang X.	Exp Mol Med	10.1038/s12276-021-00617-8	2021
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Phylogeny	Phylogenetic Analysis of the Bifidobacterium Genus Using Glycolysis Enzyme Sequences.	Brandt K, Barrangou R.	Front Microbiol	10.3389/fmicb.2016.00657	2016
Metabolism	Discovery of alpha-l-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42.	Viborg AH, Katayama T, Arakawa T, Abou Hachem M, Lo Leggio L, Kitaoka M, Svensson B, Fushinobu S.	J Biol Chem	10.1074/jbc.m117.792598	2017
Metabolism	Anti-colon cancer activity of Bifidobacterium metabolites on colon cancer cell line SW742.	Bahmani S, Azarpira N, Moazamian E.	Turk J Gastroenterol	10.5152/tjg.2019.18451	2019
	Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models.	Jena PK, Sheng L, Nagar N, Wu C, Barile D, Mills DA, Wan YY.	J Nutr Biochem	10.1016/j.jnutbio.2018.04.007	2018
Metabolism	Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation.	LoCascio RG, Ninonuevo MR, Freeman SL, Sela DA, Grimm R, Lebrilla CB, Mills DA, German JB.	J Agric Food Chem	10.1021/jf0710480	2007
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Metabolism	Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal.	James K, Bottacini F, Contreras JIS, Vigoureux M, Egan M, Motherway MO, Holmes E, van Sinderen D.	Sci Rep	10.1038/s41598-019-51901-7	2019
Enzymology	Highly efficient chemoenzymatic synthesis of beta1-3-linked galactosides.	Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X.	Chem Commun (Camb)	10.1039/c0cc02850a	2010
Metabolism	Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function.	Luck B, Engevik MA, Ganesh BP, Lackey EP, Lin T, Balderas M, Major A, Runge J, Luna RA, Sillitoe RV, Versalovic J.	Sci Rep	10.1038/s41598-020-64173-3	2020
Enzymology	Genetic diversity of bile salt hydrolases among human intestinal bifidobacteria.	Jarocki P, Targonski Z.	Curr Microbiol	10.1007/s00284-013-0362-1	2013
Metabolism	Analysis of predicted carbohydrate transport systems encoded by Bifidobacterium bifidum PRL2010.	Turroni F, Strati F, Foroni E, Serafini F, Duranti S, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.00629-12	2012
Genetics	The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut.	Albert K, Rani A, Sela DA.	Microb Genom	10.1099/mgen.0.000183	2018
	Bifidobacterial beta-Galactosidase-Mediated Production of Galacto-Oligosaccharides: Structural and Preliminary Functional Assessments.	Ambrogi V, Bottacini F, Mac Sharry J, van Breen J, O'Keeffe E, Walsh D, Schoemaker B, Cao L, Kuipers B, Lindner C, Jimeno ML, Doyaguez EG, Hernandez-Hernandez O, Moreno FJ, Schoterman M, van Sinderen D.	Front Microbiol	10.3389/fmicb.2021.750635	2021
	Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota.	Underwood MA, Arriola J, Gerber CW, Kaveti A, Kalanetra KM, Kananurak A, Bevins CL, Mills DA, Dvorak B.	Pediatr Res	10.1038/pr.2014.102	2014
	Bifidobacterium mongoliense genome seems particularly adapted to milk oligosaccharide digestion leading to production of antivirulent metabolites.	Bondue P, Milani C, Arnould E, Ventura M, Daube G, LaPointe G, Delcenserie V.	BMC Microbiol	10.1186/s12866-020-01804-9	2020
	Prevalence of Antibiotic Resistance Genes among Human Gut-Derived Bifidobacteria.	Duranti S, Lugli GA, Mancabelli L, Turroni F, Milani C, Mangifesta M, Ferrario C, Anzalone R, Viappiani A, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02894-16	2017
Genetics	Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine Bifidobacterium Species.	Zafar H, Saier MH.	Microb Physiol	10.1159/000518954	2022
Enzymology	Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin.	Yu JB, Zhao ZX, Peng R, Pan LB, Fu J, Ma SR, Han P, Cong L, Zhang ZW, Sun LX, Jiang JD, Wang Y.	Front Pharmacol	10.3389/fphar.2019.00268	2019
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Metabolism	Characterization of the serpin-encoding gene of Bifidobacterium breve 210B.	Turroni F, Foroni E, O'Connell Motherway M, Bottacini F, Giubellini V, Zomer A, Ferrarini A, Delledonne M, Zhang Z, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02938-09	2010
Metabolism	Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides.	Sela DA, Mills DA.	Trends Microbiol	10.1016/j.tim.2010.03.008	2010
Metabolism	Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity.	Morais J, Marques C, Faria A, Teixeira D, Barreiros-Mota I, Durao C, Araujo J, Ismael S, Brito S, Cardoso M, Macedo I, Pereira E, Tome T, Calhau C.	Nutrients	10.3390/nu13051564	2021
Metabolism	Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications.	Garrido D, Dallas DC, Mills DA.	Microbiology (Reading)	10.1099/mic.0.064113-0	2013
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Metabolism	Prebiotics Mediate Microbial Interactions in a Consortium of the Infant Gut Microbiome.	Medina DA, Pinto F, Ovalle A, Thomson P, Garrido D.	Int J Mol Sci	10.3390/ijms18102095	2017
	Probiotics to improve the gut microbiome in premature infants: are we there yet?	Mercer EM, Arrieta MC.	Gut Microbes	10.1080/19490976.2023.2201160	2023
	Bifidogenic and butyrogenic effects of young barely leaf extract in an in vitro human colonic microbiota model.	Sasaki D, Sasaki K, Kadowaki Y, Aotsuka Y, Kondo A.	AMB Express	10.1186/s13568-019-0911-5	2019
Metabolism	A versatile and scalable strategy for glycoprofiling bifidobacterial consumption of human milk oligosaccharides.	Locascio RG, Ninonuevo MR, Kronewitter SR, Freeman SL, German JB, Lebrilla CB, Mills DA.	Microb Biotechnol	10.1111/j.1751-7915.2008.00072.x	2009
	Granzyme B⁺ CD4 T cells accumulate in the colon during chronic HIV-1 infection.	Dillon SM, Mickens KL, Thompson TA, Cooper EH, Nesladek S, Christians AJ, Castleman M, Guo K, Wood C, Frank DN, Kechris K, Santiago ML, Wilson CC.	Gut Microbes	10.1080/19490976.2022.2045852	2022
	Characterization and induction of prophages in human gut-associated Bifidobacterium hosts.	Mavrich TN, Casey E, Oliveira J, Bottacini F, James K, Franz CMAP, Lugli GA, Neve H, Ventura M, Hatfull GF, Mahony J, van Sinderen D.	Sci Rep	10.1038/s41598-018-31181-3	2018
Metabolism	Substrate preference of an ABC importer corresponds to selective growth on beta-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis.	Theilmann MC, Fredslund F, Svensson B, Lo Leggio L, Abou Hachem M.	J Biol Chem	10.1074/jbc.ra119.008843	2019
	Modeling Metabolic Interactions in a Consortium of the Infant Gut Microbiome.	Pinto F, Medina DA, Perez-Correa JR, Garrido D.	Front Microbiol	10.3389/fmicb.2017.02507	2017
	Consortium of Probiotics Attenuates Colonization of Clostridioides difficile.	Li X, Chu Q, Huang Y, Xiao Y, Song L, Zhu S, Kang Y, Lu S, Xu J, Ren Z.	Front Microbiol	10.3389/fmicb.2019.02871	2019
Pathogenicity	Intestinal 'Infant-Type' Bifidobacteria Mediate Immune System Development in the First 1000 Days of Life.	Lin C, Lin Y, Zhang H, Wang G, Zhao J, Zhang H, Chen W.	Nutrients	10.3390/nu14071498	2022
	An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis.	Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N.	Oncogenesis	10.1038/oncsis.2016.38	2016
Genetics	Comparative Genomics Reveals the Regulatory Complexity of Bifidobacterial Arabinose and Arabino-Oligosaccharide Utilization.	Arzamasov AA, van Sinderen D, Rodionov DA.	Front Microbiol	10.3389/fmicb.2018.00776	2018
Genetics	Bifidobacterium Bacteremia: Clinical Characteristics and a Genomic Approach To Assess Pathogenicity.	Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C, Norwegian Study Group on Invasive Bifidobacterial Infections.	J Clin Microbiol	10.1128/jcm.00150-17	2017
Metabolism	Enterococcus faecalis Glucosamine Metabolism Exacerbates Experimental Colitis.	Fan TJ, Goeser L, Lu K, Faith JJ, Hansen JJ.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2021.06.017	2021
	Biochemical analysis of cross-feeding behaviour between two common gut commensals when cultivated on plant-derived arabinogalactan.	Munoz J, James K, Bottacini F, Van Sinderen D.	Microb Biotechnol	10.1111/1751-7915.13577	2020
Genetics	Genome-wide identification of small RNAs in Bifidobacterium animalis subsp. lactis KLDS 2.0603 and their regulation role in the adaption to gastrointestinal environment.	Zhu DQ, Liu F, Sun Y, Yang LM, Xin L, Meng XC.	PLoS One	10.1371/journal.pone.0117373	2015
Metabolism	Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages.	Fan TJ, Goeser L, Naziripour A, Redinbo MR, Hansen JJ.	Infect Immun	10.1128/iai.00080-19	2019
Pathogenicity	Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites.	Liu DQ, Gao QY, Liu HB, Li DH, Wu SW.	World J Gastroenterol	10.3748/wjg.v19.i25.4053	2013
Pathogenicity	In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications.	Krumbeck JA, Maldonado-Gomez MX, Martinez I, Frese SA, Burkey TE, Rasineni K, Ramer-Tait AE, Harris EN, Hutkins RW, Walter J.	Appl Environ Microbiol	10.1128/aem.03903-14	2015
	Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.	Engevik MA, Morra CN, Roth D, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic J.	Front Microbiol	10.3389/fmicb.2019.02305	2019
	Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.	Petrova P, Ivanov I, Tsigoriyna L, Valcheva N, Vasileva E, Parvanova-Mancheva T, Arsov A, Petrov K.	Microorganisms	10.3390/microorganisms9030480	2021
Metabolism	Studying Lactoferrin N-Glycosylation.	Karav S, German JB, Rouquie C, Le Parc A, Barile D.	Int J Mol Sci	10.3390/ijms18040870	2017
	Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments.	Bargheet A, Klingenberg C, Esaiassen E, Hjerde E, Cavanagh JP, Bengtsson-Palme J, Pettersen VK.	EBioMedicine	10.1016/j.ebiom.2023.104613	2023
	Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food.	Yan X, Gurtler JB, Fratamico PM, Hu J, Juneja VK.	Cell Biosci	10.1186/2045-3701-2-39	2012
Genetics	Genomics of the Genus Bifidobacterium Reveals Species-Specific Adaptation to the Glycan-Rich Gut Environment.	Milani C, Turroni F, Duranti S, Lugli GA, Mancabelli L, Ferrario C, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.03500-15	2016
Enzymology	A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space.	Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney JA, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M.	Microbiome	10.1186/s40168-018-0545-x	2018
Metabolism	Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens.	O'Sullivan JN, Rea MC, O'Connor PM, Hill C, Ross RP.	FEMS Microbiol Ecol	10.1093/femsec/fiy241	2019
	Probiotic administration in congenital heart disease: a pilot study.	Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L, Schegg T, Rutledge JC, Raff G, Mills DA, Underwood MA.	J Perinatol	10.1038/jp.2013.41	2013
	The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota.	Yu ZT, Chen C, Kling DE, Liu B, McCoy JM, Merighi M, Heidtman M, Newburg DS.	Glycobiology	10.1093/glycob/cws138	2013
	Immobilization of an Endo-beta-N-acetylglucosaminidase for the Release of Bioactive N-glycans.	Cohen JL, Karav S, Barile D, de Moura Bell JMLN.	Catalysts	10.3390/catal8070278	2018
Pathogenicity	Exploring the Ecology of Bifidobacteria and Their Genetic Adaptation to the Mammalian Gut.	Duranti S, Longhi G, Ventura M, van Sinderen D, Turroni F.	Microorganisms	10.3390/microorganisms9010008	2020
	Enteric bacteria induce IFNgamma and Granzyme B from human colonic Group 1 Innate Lymphoid Cells.	Castleman MJ, Dillon SM, Purba C, Cogswell AC, McCarter M, Barker E, Wilson C.	Gut Microbes	10.1080/19490976.2019.1667723	2020
Genetics	Comparative genomic and phylogenomic analyses of the Bifidobacteriaceae family.	Lugli GA, Milani C, Turroni F, Duranti S, Mancabelli L, Mangifesta M, Ferrario C, Modesto M, Mattarelli P, Jiri K, van Sinderen D, Ventura M.	BMC Genomics	10.1186/s12864-017-3955-4	2017
Metabolism	Probiotics genomics.	Siezen RJ, Wilson G.	Microb Biotechnol	10.1111/j.1751-7915.2009.00159.x	2010
	Evaluation of Microbial-Fructo-Oligosaccharides Metabolism by Human Gut Microbiota Fermentation as Compared to Commercial Inulin-Derived Oligosaccharides.	Roupar D, Coelho MC, Goncalves DA, Silva SP, Coelho E, Silva S, Coimbra MA, Pintado M, Teixeira JA, Nobre C.	Foods	10.3390/foods11070954	2022
	Effects of probiotic drop containing Lactobacillus rhamnosus, Bifidobacterium infantis, and Lactobacillus reuteri on salivary Streptococcus mutans and Lactobacillus levels.	Tehrani MH, Akhlaghi N, Talebian L, Emami J, Keyhani SE.	Contemp Clin Dent	10.4103/0976-237x.194102	2016
Genetics	Transcriptional Regulation of Carbohydrate Utilization Pathways in the Bifidobacterium Genus.	Khoroshkin MS, Leyn SA, Van Sinderen D, Rodionov DA.	Front Microbiol	10.3389/fmicb.2016.00120	2016
Metabolism	Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria.	Letzel AC, Pidot SJ, Hertweck C.	BMC Genomics	10.1186/1471-2164-15-983	2014
Enzymology	Sialidases from gut bacteria: a mini-review.	Juge N, Tailford L, Owen CD.	Biochem Soc Trans	10.1042/bst20150226	2016
Pathogenicity	Impact of Phlorotannin Extracts from Fucus vesiculosus on Human Gut Microbiota.	Catarino MD, Marcal C, Bonifacio-Lopes T, Campos D, Mateus N, Silva AMS, Pintado MM, Cardoso SM.	Mar Drugs	10.3390/md19070375	2021
Metabolism	Bile-inducible efflux transporter from Bifidobacterium longum NCC2705, conferring bile resistance.	Gueimonde M, Garrigues C, van Sinderen D, de los Reyes-Gavilan CG, Margolles A.	Appl Environ Microbiol	10.1128/aem.00172-09	2009
Metabolism	Development of a double-crossover markerless gene deletion system in Bifidobacterium longum: functional analysis of the alpha-galactosidase gene for raffinose assimilation.	Hirayama Y, Sakanaka M, Fukuma H, Murayama H, Kano Y, Fukiya S, Yokota A.	Appl Environ Microbiol	10.1128/aem.00588-12	2012
Metabolism	Fucosidases from the human gut symbiont Ruminococcus gnavus.	Wu H, Rebello O, Crost EH, Owen CD, Walpole S, Bennati-Granier C, Ndeh D, Monaco S, Hicks T, Colvile A, Urbanowicz PA, Walsh MA, Angulo J, Spencer DIR, Juge N.	Cell Mol Life Sci	10.1007/s00018-020-03514-x	2021
Phylogeny	Probiotic Cocktail Identified by Microbial Network Analysis Inhibits Growth, Virulence Gene Expression, and Host Cell Colonization of Vancomycin-Resistant Enterococci.	Sun WS, Lee YJ, Tsai KN, Ho YH, Fang SB.	Microorganisms	10.3390/microorganisms8060816	2020
	Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases.	Plaza-Diaz J, Ruiz-Ojeda FJ, Vilchez-Padial LM, Gil A.	Nutrients	10.3390/nu9060555	2017
	Mucin glycan foraging in the human gut microbiome.	Tailford LE, Crost EH, Kavanaugh D, Juge N.	Front Genet	10.3389/fgene.2015.00081	2015
Genetics	Comparative genomics of the Bifidobacterium breve taxon.	Bottacini F, O'Connell Motherway M, Kuczynski J, O'Connell KJ, Serafini F, Duranti S, Milani C, Turroni F, Lugli GA, Zomer A, Zhurina D, Riedel C, Ventura M, van Sinderen D.	BMC Genomics	10.1186/1471-2164-15-170	2014
Metabolism	Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation.	Nishiyama K, Yamamoto Y, Sugiyama M, Takaki T, Urashima T, Fukiya S, Yokota A, Okada N, Mukai T.	mBio	10.1128/mbio.00928-17	2017
Phylogeny	Comparative genomics of Bifidobacterium animalis subsp. lactis reveals a strict monophyletic bifidobacterial taxon.	Milani C, Duranti S, Lugli GA, Bottacini F, Strati F, Arioli S, Foroni E, Turroni F, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.00984-13	2013
Genetics	The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota.	Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J, Belzer C, Delgado Palacio S, Arboleya Montes S, Mancabelli L, Lugli GA, Rodriguez JM, Bode L, de Vos W, Gueimonde M, Margolles A, van Sinderen D, Ventura M.	Microbiol Mol Biol Rev	10.1128/mmbr.00036-17	2017
	Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants.	Lewis ZT, Totten SM, Smilowitz JT, Popovic M, Parker E, Lemay DG, Van Tassell ML, Miller MJ, Jin YS, German JB, Lebrilla CB, Mills DA.	Microbiome	10.1186/s40168-015-0071-z	2015
	Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFNgamma Production From Human Colonic ILC3s via Multiple Mechanisms.	Castleman MJ, Dillon SM, Purba CM, Cogswell AC, Kibbie JJ, McCarter MD, Santiago ML, Barker E, Wilson CC.	Front Immunol	10.3389/fimmu.2019.00649	2019
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	Bifidobacterium longum subsp. infantis YLGB-1496-Toxicological evaluation.	Zhao J, Guo Y, Jiang Q, Lan H, Hung WL, Lynch B.	J Appl Toxicol	10.1002/jat.4688	2025
	Oral supplementation with Bifidobacterium longum ssp. infantis and 2'-fucosyllactose revives gut microbiota perturbation and intestinal and immune developmental delay following early-life antibiotic challenge in BALB/c mice.	Luo Y, Li J, Wu S, Jia W, Zhou Z, Liu M, Jiang F, Huang T, Shen X, Li Y, He F, Cheng R.	J Dairy Sci	10.3168/jds.2024-24912	2025
	Home administration of a multistrain probiotic once per day for 4 weeks to newborn infants in Tanzania (ProRIDE): a double-blind, placebo-controlled randomised trial.	Klingenberg C, Justine M, Moyo SJ, Lohr IH, Gideon J, Mdoe P, Mduma E, Manyahi J, Bargheet A, Pettersen VK, Paschal J, Syre H, Bernhoff E, Bukhay R, Blomberg B, Langeland N.	Lancet Glob Health	10.1016/s2214-109x(25)00064-6	2025
Metabolism	Molecular insights into FucR transcription factor to control the metabolism of _L-fucose in Bifidobacterium longum subsp. infantis.	Yang X, Zhang J, Zhu J, Yang R, Tong Y.	Microbiol Res	10.1016/j.micres.2024.127709	2024
	Probiotic supplementation for optimizing athletic performance: current evidence and future perspectives for microbiome-based strategies.	Teglas T, Radak Z.	Front Nutr	10.3389/fnut.2025.1572687	2025
	Exopolysaccharides from Bifidobacterium longum subsp. infantis and Bifidobacterium adolescentis modulate Toll-like receptor signaling	Akkerman R, Oerlemans MMP, Ferrari M, Fernandez-Lainez C, Walvoort MTC, De Vos P.	Carbohydrate polymers.		2024
	Enhancement of IgA production by membrane vesicles derived from Bifidobacterium longum subsp. infantis.	Kurata A, Yamasaki-Yashiki S, Imai T, Miyazaki A, Watanabe K, Uegaki K.	Biosci Biotechnol Biochem	10.1093/bbb/zbac172	2022
	[Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens].	Moreno-Munoz JA, Martin-Palomas M, Jimenez Lopez J.	Nutr Hosp	10.20960/nh.04315	2022
	A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.	Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, Patel J, Jadon PS, Pandit A, Dargad RR, Khanna S, Kumar S, Day R.	Gut Microbes	10.1080/19490976.2024.2338322	2024
	Cholesterol-Lowering Mechanism of Lactobacillus Bile Salt Hydrolase Through Regulation of Bifidobacterium pseudolongum in the Gut Microbiota.	Liu Y, Kuang W, Li M, Wang Z, Liu Y, Zhao M, Huan H, Yang Y.	Nutrients	10.3390/nu17183019	2025
	Probiotics as technological innovations in psychiatric disorders: patents and research reviews.	de Lima AA, Santos SS, de Araujo MA, Vinderola G, Villarreal CF, Viana MDM.	Front Nutr	10.3389/fnut.2025.1567097	2025
	Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players.	Sadeghi R, Hemmatinafar M, Eftekhari F, Imanian B, Koureshfard N.	J Int Soc Sports Nutr	10.1080/15502783.2025.2505184	2025
	The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.	Moludi J, Saber A, Zozani MA, Moradi S, Azamian Y, Hajiahmadi S, Pasdar Y, Moradi F.	Prev Nutr Food Sci	10.3746/pnf.2024.29.3.237	2024
	Efficacy of bifidobacterium-related preparations on depression: the first meta-analysis.	Huang R, Liu Y.	Front Psychiatry	10.3389/fpsyt.2024.1463848	2024
	Using bifidobacterium and propionibacterium strains in probiotic consortia to normalize the gastrointestinal tract.	Dyshlyuk LS, Milentyeva IS, Asyakina LK, Ostroumov LA, Osintsev AM, Pozdnyakova AV.	Braz J Biol	10.1590/1519-6984.256945	2022
	Fecal bacterial microbiota in constipated patients before and after eight weeks of daily Bifidobacterium infantis 35624 administration.	Amieva-Balmori M, Garcia-Mazcorro JF, Martinez-Conejo A, Hernandez-Ramirez GA, Garcia-Zermeno KR, Rodriguez-Aguilera O, Aja-Cadena M, Barradas-Cortes M, Quigley EMM, Remes-Troche JM.	Rev Gastroenterol Mex (Engl Ed)	10.1016/j.rgmxen.2022.06.014	2023
	In Vivo Investigation of Supportive Immunotherapeutic Combination of Bifidobacterium infantis 35624 and Doxorubicin in Murine Breast Cancer.	Akbaba M, Gokmen GG, Kisla D, Nalbantsoy A.	Probiotics Antimicrob Proteins	10.1007/s12602-021-09899-w	2023
	Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effect of Two Probiotics on the Preterms' Gut Microbiota.	Moreno-Sanz B, Montes MT, Manzano S, Espinosa-Martos I, Cardenas N, Esteban S, Cruz M, Jimenez E, de Pipaon MS.	J Pediatr Gastroenterol Nutr	10.1097/mpg.0000000000003427	2022
	Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature.	Beltran-Velasco AI, Reiriz M, Uceda S, Echeverry-Alzate V.	Int J Mol Sci	10.3390/ijms25053010	2024
	Evaluating the Impact of Probiotic Therapy on the Endocannabinoid System, Pain, Sleep and Fatigue: A Randomized, Double-Blind, Placebo-Controlled Trial in Dancers.	Wiacek J, Podgorski T, Kusy K, Loniewski I, Skonieczna-Zydecka K, Karolkiewicz J.	Int J Mol Sci	10.3390/ijms25115611	2024
Pathogenicity	A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.	Jurek JM, Castro-Marrero J.	Nutrients	10.3390/nu16111545	2024
	Probiotics ameliorate endocrine disorders via modulating inflammatory pathways: a systematic review.	Nemati M, Ebrahimi B, Montazeri-Najafabady N.	Genes Nutr	10.1186/s12263-024-00743-8	2024
	The effect of probiotics and casein supplementation on aerobic capacity parameters of male soccer players.	Imanian B, Hemmatinafar M, Daryanoosh F, Koureshfard N, Sadeghi R, Niknam A, Rezaei R, Qashqaei A.	J Int Soc Sports Nutr	10.1080/15502783.2024.2382165	2024
	Nutritional Approach to Small Intestinal Bacterial Overgrowth: A Narrative Review.	Velasco-Aburto S, Llama-Palacios A, Sanchez MC, Ciudad MJ, Collado L.	Nutrients	10.3390/nu17091410	2025
Genetics	Alterations in the intestinal microbiome and metabolic profile of patients with cirrhosis supplemented with lactulose, Clostridium butyricum, and Bifidobacterium longum infantis: a randomized placebo-controlled trial.	Lu H, Zhu X, Wu L, Lou X, Pan X, Liu B, Zhang H, Zhu L, Li L, Wu Z.	Front Microbiol	10.3389/fmicb.2023.1169811	2023
Pathogenicity	The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review.	Biagioli V, Mela F, Ferraro P, Villano G, Orsini A, Diana MC, Striano P, Santangelo A.	Nutrients	10.3390/nu17020337	2025
	Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants: The PRIMAL Randomized Clinical Trial.	Van Rossum T, Haiss A, Knoll RL, Marissen J, Podlesny D, Pagel J, Bleskina M, Vens M, Fortmann I, Siller B, Ricklefs I, Klopp J, Hilbert K, Meyer C, Thielemann R, Goedicke-Fritz S, Kuntz M, Wieg C, Teig N, Korner T, Kribs A, Hudalla H, Knuf M, Stein A, Gille C, Bagci S, Dohle F, Proquitte H, Olbertz DM, Schmidt E, Koch L, Pirr S, Rupp J, Spiegler J, Kopp MV, Gopel W, Herting E, Forslund SK, Viemann D, Zemlin M, Bork P, Gehring S, Konig IR, Henneke P, Hartel C.	JAMA Pediatr	10.1001/jamapediatrics.2024.2626	2024
	Current Insights into the Use of Probiotics and Fatty Acids in Alleviating Depression.	Gao H, He C, Xin S, Hua R, Du Y, Wang B, Gong F, Yu X, Pan L, Gao L, Xu J.	Microorganisms	10.3390/microorganisms11082018	2023
	The impact of Streptococcus thermophilus IDCC 2201 on gut microbiota and its potential as a prophylactic agent for colorectal cancer.	Nam EH, Lee M, Kim H, Kim D, Lee Y, Jung YH, Yang J, Shin M.	Sci Rep	10.1038/s41598-025-20976-w	2025
	The role of probiotics in improving menstrual health in women with primary dysmenorrhoea: A randomized, double-blind, placebo-controlled trial (the PERIOD study).	Zakaria IA, Mohammed Zain NA, Teik CK, Abu MA, Zainuddin AA, Abdul Aziz NH, Safian N, Mohd Mokhtar N, Raja Ali RA, Beng Kwang N, Mohamed Ismail NA, Hamizan MR, Ab Razak WS, Nur Azurah AG.	Womens Health (Lond)	10.1177/17455057241234524	2024
	Bovine glycomacropeptide promotes the growth of Bifidobacterium longum ssp. infantis and modulates its gene expression.	O'Riordan N, O'Callaghan J, Butto LF, Kilcoyne M, Joshi L, Hickey RM.	J Dairy Sci	10.3168/jds.2018-14499	2018
	Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial.	Escribano J, Ferre N, Gispert-Llaurado M, Luque V, Rubio-Torrents C, Zaragoza-Jordana M, Polanco I, Codoner FM, Chenoll E, Morera M, Moreno-Munoz JA, Rivero M, Closa-Monasterolo R.	Pediatr Res	10.1038/pr.2018.34	2018
	Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases.	Deng F, Yang D, Qing L, Chen Y, Zou J, Jia M, Wang Q, Jiang R, Huang L.	Neural Regen Res	10.4103/nrr.nrr-d-24-00607	2025
	Functional Abdominal Bloating and Gut Microbiota: An Update.	Crucilla S, Caldart F, Michelon M, Marasco G, Costantino A.	Microorganisms	10.3390/microorganisms12081669	2024
	The Effect of Bifidobacterium on Reducing Symptomatic Abdominal Pain in Patients with Irritable Bowel Syndrome: A Systematic Review.	Pratt C, Campbell MD.	Probiotics Antimicrob Proteins	10.1007/s12602-019-09609-7	2020
Pathogenicity	Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp. infantis in vitro and in humanised mice.	Musilova S, Modrackova N, Hermanova P, Hudcovic T, Svejstil R, Rada V, Tejnecky V, Bunesova V.	Benef Microbes	10.3920/bm2016.0138	2017
Phylogeny	Golden bifid might improve diarrhea-predominant irritable bowel syndrome via microbiota modulation.	Luo M, Liu Q, Xiao L, Xiong LS.	J Health Popul Nutr	10.1186/s41043-022-00302-0	2022
Metabolism	Effect of Bifidobacterium infantis 35624 (Align) on the Lactulose Breath Test for Small Intestinal Bacterial Overgrowth.	Kumar K, Saadi M, Ramsey FV, Schey R, Parkman HP.	Dig Dis Sci	10.1007/s10620-018-4945-3	2018
Pathogenicity	Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review.	Shirazinia R, Golabchifar AA, Fazeli MR.	Clin Exp Pediatr	10.3345/cep.2020.01676	2021
	Prebiotic and Probiotic Modulation of the Microbiota-Gut-Brain Axis in Depression.	Radford-Smith DE, Anthony DC.	Nutrients	10.3390/nu15081880	2023
	Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study.	Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M.	Nutrients	10.3390/nu12041159	2020
	Probiotic characteristics and in vitro compatibility of a combination of Bifidobacterium breve M-16 V, Bifidobacterium longum subsp. infantis M-63 and Bifidobacterium longum subsp. longum BB536	Toscano M, De Vecchi E, Gabrieli A, Zuccotti GV, Drago L.	Ann Microbiol	10.1007/s13213-014-0953-5	2015
Metabolism	Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.	Meng D, Sommella E, Salviati E, Campiglia P, Ganguli K, Djebali K, Zhu W, Walker WA.	Pediatr Res	10.1038/s41390-019-0740-x	2020
	Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.	Yuan F, Ni H, Asche CV, Kim M, Walayat S, Ren J.	Curr Med Res Opin	10.1080/03007995.2017.1292230	2017
Metabolism	Characterization of ATPase activity of the AAA ARC from Bifidobacterium longum subsp. infantis.	Guzman-Rodriguez M, de la Rosa AP, Santos L.	Acta Biochim Pol	10.18388/abp.2014_920	2015
	Changes of intestinal bacterial microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease.	Zhang Y, Xu J, Wang X, Ren X, Liu Y.	BMC Genomics	10.1186/s12864-019-6251-7	2019
Pathogenicity	Intestinal microbiota modulates neuroinflammatory response and brain injury after neonatal hypoxia-ischemia.	Drobyshevsky A, Synowiec S, Goussakov I, Fabres R, Lu J, Caplan M.	Gut Microbes	10.1080/19490976.2024.2333808	2024
	A Review of the Impact of Maternal Prenatal Stress on Offspring Microbiota and Metabolites.	Yeramilli V, Cheddadi R, Shah J, Brawner K, Martin C.	Metabolites	10.3390/metabo13040535	2023
	Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate the Benefit of the Probiotic Bifidobacterium infantis 35624 in Non-Patients With Symptoms of Abdominal Discomfort and Bloating.	Ringel-Kulka T, McRorie J, Ringel Y.	Am J Gastroenterol	10.1038/ajg.2016.511	2017
Phylogeny	Strategies for the Identification and Assessment of Bacterial Strains with Specific Probiotic Traits.	Torres-Maravilla E, Reyes-Pavon D, Benitez-Cabello A, Gonzalez-Vazquez R, Ramirez-Chamorro LM, Langella P, Bermudez-Humaran LG.	Microorganisms	10.3390/microorganisms10071389	2022
Metabolism	Ultrasound Attenuation Improves Some Surface Properties of the Probiotic Strain Lacticaseibacillus casei ATCC 393.	Giordano I, Mauriello G.	Microorganisms	10.3390/microorganisms11010142	2023
	A Narrative Review of Intestinal Microbiota's Impact on Migraine with Psychopathologies.	Francavilla M, Facchetti S, Demartini C, Zanaboni AM, Amoroso C, Bottiroli S, Tassorelli C, Greco R.	Int J Mol Sci	10.3390/ijms25126655	2024
Pathogenicity	Cytotoxic damage of soybean agglutinin on intestinal epithelial cells of broiler chicks: in vitro protection by Bifidobacterium infantis CRL1395.	Babot JD, Arganaraz-Martinez E, Lorenzo-Pisarello MJ, Apella MC, Perez Chaia A.	FEMS Microbiol Lett	10.1093/femsle/fnw114	2016
	Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease.	Elian SD, Souza EL, Vieira AT, Teixeira MM, Arantes RM, Nicoli JR, Martins FS.	Benef Microbes	10.3920/bm2014.0070	2015
Pathogenicity	The gut microbiome in Alzheimer's disease: what we know and what remains to be explored.	Chandra S, Sisodia SS, Vassar RJ.	Mol Neurodegener	10.1186/s13024-023-00595-7	2023
	The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.	Wu Y, Li Y, Zheng Q, Li L.	Nutrients	10.3390/nu16132114	2024
	Challenges in the production and use of probiotics as therapeuticals in cancer treatment or prevention.	Mejia-Caballero A, Salas-Villagran VA, Jimenez-Serna A, Farres A.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab052	2021
Pathogenicity	Neuroinflammation and Schizophrenia: New Therapeutic Strategies through Psychobiotics, Nanotechnology, and Artificial Intelligence (AI).	Mosquera FEC, Guevara-Montoya MC, Serna-Ramirez V, Liscano Y.	J Pers Med	10.3390/jpm14040391	2024
	Gut microbes combined with metabolomics reveal the protective effects of Qijia Rougan decoction against CCl₄-induced hepatic fibrosis.	Li X, Xu X, Tao S, Su Y, Wen L, Wang D, Liu J, Feng Q.	Front Pharmacol	10.3389/fphar.2024.1347120	2024
	Discovery of lipids from B. longum subsp. infantis using whole cell MALDI analysis.	Timmer MS, Sauvageau J, Foster AJ, Ryan J, Lagutin K, Shaw O, Harper JL, Sims IM, Stocker BL.	J Org Chem	10.1021/jo501016c	2014
	Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression.	Huang F, Wu X.	Front Cell Dev Biol	10.3389/fcell.2021.649103	2021
	Efficacy of an Irritable Bowel Syndrome Diet in the Treatment of Small Intestinal Bacterial Overgrowth: A Narrative Review.	Wielgosz-Grochowska JP, Domanski N, Drywien ME.	Nutrients	10.3390/nu14163382	2022
Metabolism	Comparative proteome analysis of Bifidobacterium longum subsp. infantis grown on beta-glucans from different sources and a model for their utilization.	Zhao J, Cheung PC.	J Agric Food Chem	10.1021/jf400792j	2013
	Probiotics in Wound Healing.	Badaluta VA, Curutiu C, Ditu LM, Holban AM, Lazar V.	Int J Mol Sci	10.3390/ijms25115723	2024
	The effect of a single-strain probiotic administration in the treatment of thermal burns patients.	Perdanakusuma DS, Hariani L, Nasser NF, Datusanantyo RA.	Iran J Microbiol		2019
Phylogeny	Efficiency of PCR-based methods in discriminating Bifidobacterium longum ssp. longum and Bifidobacterium longum ssp. infantis strains of human origin.	Srutkova D, Spanova A, Spano M, Drab V, Schwarzer M, Kozakova H, Rittich B.	J Microbiol Methods	10.1016/j.mimet.2011.06.014	2011
Pathogenicity	Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches.	Buhas MC, Candrea R, Gavrilas LI, Miere D, Tataru A, Boca A, Catinean A.	Int J Mol Sci	10.3390/ijms241311225	2023
	Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis.	Kitae H, Takagi T, Naito Y, Inoue R, Azuma Y, Torii T, Mizushima K, Doi T, Inoue K, Dohi O, Yoshida N, Kamada K, Uchiyama K, Ishikawa T, Konishi H, Itoh Y.	Microorganisms	10.3390/microorganisms10051044	2022
Enzymology	In vitro evaluation of Bifidobacterium strains of human origin for potential use in probiotic functional foods.	Souza TC, Silva AM, Drews JR, Gomes DA, Vinderola CG, Nicoli JR.	Benef Microbes	10.3920/bm2012.0052	2013
Metabolism	Bifidobacterium longum subsp. infantis uses two different beta-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides.	Yoshida E, Sakurama H, Kiyohara M, Nakajima M, Kitaoka M, Ashida H, Hirose J, Katayama T, Yamamoto K, Kumagai H.	Glycobiology	10.1093/glycob/cwr116	2012
	Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-beta1-Induced Intestinal Fibrosis on CCD-18Co Cells.	Lombardi F, Augello FR, Palumbo P, Mollsi E, Giuliani M, Cimini AM, Cifone MG, Cinque B.	Nutrients	10.3390/nu13030882	2021
	Application of ultrasound and microencapsulation on Limosilactobacillus reuteri DSM 17938 as a metabolic attenuation strategy for tomato juice probiotication.	Giordano I, Abuqwider J, Altamimi M, Di Monaco R, Puleo S, Mauriello G.	Heliyon	10.1016/j.heliyon.2022.e10969	2022
	The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis.	Zhang R, Zhang M, Wang P.	Front Nutr	10.3389/fnut.2025.1539355	2025
	Safety and acceptability of Lactobacillus reuteri DSM 17938 and Bifidobacterium longum subspecies infantis 35624 in Bangladeshi infants: a phase I randomized clinical trial.	Hoy-Schulz YE, Jannat K, Roberts T, Zaidi SH, Unicomb L, Luby S, Parsonnet J.	BMC Complement Altern Med	10.1186/s12906-016-1016-1	2016
	The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review.	Jakubczyk D, Leszczynska K, Gorska S.	Nutrients	10.3390/nu12071973	2020
	The Different Ways Multi-Strain Probiotics with Different Ratios of Bifidobacterium and Lactobacillus Relieve Constipation Induced by Loperamide in Mice.	Zhang C, Wang L, Liu X, Wang G, Guo X, Liu X, Zhao J, Chen W.	Nutrients	10.3390/nu15194230	2023
	Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment.	Xia C, Cai Y, Ren S, Xia C.	Front Pharmacol	10.3389/fphar.2022.1051330	2022
Metabolism	In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longum biovar infantis.	Vulevic J, Gibson GR.	J Appl Microbiol	10.1111/j.1365-2672.2008.03886.x	2008
	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications.	Varesi A, Deumer US, Ananth S, Ricevuti G.	J Clin Med	10.3390/jcm10215077	2021
Metabolism	Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors.	Meng D, Zhu W, Ganguli K, Shi HN, Walker WA.	Am J Physiol Gastrointest Liver Physiol	10.1152/ajpgi.00090.2016	2016
	Fermentative Production of Diacylglycerol by Endophytic Fungi Screened from Taxus chinensis var. mairei.	Xu W, Bi H, Peng H, Yang L, He H, Fu G, Liu Y, Wan Y.	Foods	10.3390/foods12020399	2023
	Determination of reactive oxygen generated from natural medicines and their antibacterial activity.	Tajima N, Takasaki M, Fukamachi H, Igarashi T, Nakajima Y, Arakawa H.	J Pharm Anal	10.1016/j.jpha.2016.04.003	2016
	Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial.	Smilowitz JT, Moya J, Breck MA, Cook C, Fineberg A, Angkustsiri K, Underwood MA.	BMC Pediatr	10.1186/s12887-017-0886-9	2017
	Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence.	Przemska-Kosicka A, Childs CE, Enani S, Maidens C, Dong H, Dayel IB, Tuohy K, Todd S, Gosney MA, Yaqoob P.	Immun Ageing	10.1186/s12979-016-0061-4	2016
Metabolism	In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria.	Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB.	Mol Nutr Food Res	10.1002/mnfr.200700150	2007
Pathogenicity	Cross-Talk Between Gluten, Intestinal Microbiota and Intestinal Mucosa in Celiac Disease: Recent Advances and Basis of Autoimmunity.	Chander AM, Yadav H, Jain S, Bhadada SK, Dhawan DK.	Front Microbiol	10.3389/fmicb.2018.02597	2018
	Are there any different effects of Bifidobacterium, Lactobacillus and Streptococcus on intestinal sensation, barrier function and intestinal immunity in PI-IBS mouse model?	Wang H, Gong J, Wang W, Long Y, Fu X, Fu Y, Qian W, Hou X.	PLoS One	10.1371/journal.pone.0090153	2014
Enzymology	Characterization of bacterial isolates from the microbiota of mothers' breast milk and their infants.	Kozak K, Charbonneau D, Sanozky-Dawes R, Klaenhammer T.	Gut Microbes	10.1080/19490976.2015.1103425	2015
	Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?	Dickison L, Gonzalez-Shalaby C.	Adv Neonatal Care	10.1097/anc.0000000000000983	2022
	Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives.	Chung M, Bartholomew E, Yeroushalmi S, Hakimi M, Bhutani T, Liao W.	Psoriasis (Auckl)	10.2147/ptt.s328581	2022
	Protective Effects and Mechanism of a Novel Probiotic Strain Ligilactobacillus salivarius YL20 against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and In Vivo.	Wang W, Geng M, Zhu C, Huang L, Zhang Y, Zhang T, Zhao C, Zhang T, Du X, Wang N.	Nutrients	10.3390/nu14183827	2022
	Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells.	Takano T, Endo R, Wang Y, Nakajima-Adachi H, Hachimura S.	Biosci Microbiota Food Health	10.12938/bmfh.19-019	2020
	The Efficacy of Probiotics, Prebiotic Inulin-Type Fructans, and Synbiotics in Human Ulcerative Colitis: A Systematic Review and Meta-Analysis.	Asto E, Mendez I, Audivert S, Farran-Codina A, Espadaler J.	Nutrients	10.3390/nu11020293	2019
	Probiotics for inflammatory bowel disease: Is there sufficient evidence?	Ma Y, Yang D, Huang J, Liu K, Liu H, Wu H, Bao C.	Open Life Sci	10.1515/biol-2022-0821	2024
Metabolism	Carbohydrate Syntrophy enhances the establishment of Bifidobacterium breve UCC2003 in the neonatal gut.	O'Connell Motherway M, O'Brien F, O'Driscoll T, Casey PG, Shanahan F, van Sinderen D.	Sci Rep	10.1038/s41598-018-29034-0	2018
Phylogeny	Characterization of the genus Bifidobacterium by automated ribotyping and 16S rRNA gene sequences.	Sakata S, Ryu CS, Kitahara M, Sakamoto M, Hayashi H, Fukuyama M, Benno Y.	Microbiol Immunol	10.1111/j.1348-0421.2006.tb03762.x	2006
	Portrait of an immunoregulatory Bifidobacterium.	Konieczna P, Akdis CA, Quigley EM, Shanahan F, O'Mahony L.	Gut Microbes	10.4161/gmic.20358	2012
	Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review.	Wang Y, Zhu J, Zou N, Zhang L, Wang Y, Zhang M, Wang C, Yang L.	Front Integr Neurosci	10.3389/fnint.2023.1051689	2023
	Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.	Biagioli M, Capobianco D, Carino A, Marchiano S, Fiorucci C, Ricci P, Distrutti E, Fiorucci S.	Nutrients	10.3390/nu11020325	2019
	Host-microbiota interactions shaping T-cell response and tolerance in type 1 diabetes.	Majumdar S, Lin Y, Bettini ML.	Front Immunol	10.3389/fimmu.2022.974178	2022
	Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial.	De Lorenzo A, Costacurta M, Merra G, Gualtieri P, Cioccoloni G, Marchetti M, Varvaras D, Docimo R, Di Renzo L.	J Transl Med	10.1186/s12967-017-1236-2	2017
	Maternal administration of probiotics promotes gut development in mouse offsprings.	Yu Y, Lu J, Oliphant K, Gupta N, Claud K, Lu L.	PLoS One	10.1371/journal.pone.0237182	2020
Phylogeny	Comparative Analysis of 16S rRNA Gene and Metagenome Sequencing in Pediatric Gut Microbiomes.	Peterson D, Bonham KS, Rowland S, Pattanayak CW, RESONANCE Consortium, Klepac-Ceraj V.	Front Microbiol	10.3389/fmicb.2021.670336	2021
	Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota.	Martin R, Makino H, Cetinyurek Yavuz A, Ben-Amor K, Roelofs M, Ishikawa E, Kubota H, Swinkels S, Sakai T, Oishi K, Kushiro A, Knol J.	PLoS One	10.1371/journal.pone.0158498	2016
	Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression.	Tomosada Y, Villena J, Murata K, Chiba E, Shimazu T, Aso H, Iwabuchi N, Xiao JZ, Saito T, Kitazawa H.	PLoS One	10.1371/journal.pone.0059259	2013
Pathogenicity	Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes.	Zheng N, Gao Y, Zhu W, Meng D, Walker WA.	PLoS One	10.1371/journal.pone.0229283	2020
	Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials.	Dunne C, Murphy L, Flynn S, O'Mahony L, O'Halloran S, Feeney M, Morrissey D, Thornton G, Fitzgerald G, Daly C, Kiely B, Quigley EM, O'Sullivan GC, Shanahan F, Collins JK.	Antonie Van Leeuwenhoek	10.1023/a:1002065931997	1999
	Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.	Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC.	Clin Ther	10.1016/j.clinthera.2015.04.002	2015
	Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III - convergence toward clinical trials.	Bested AC, Logan AC, Selhub EM.	Gut Pathog	10.1186/1757-4749-5-4	2013
Metabolism	Rational design of a new Trypanosoma rangeli trans-sialidase for efficient sialylation of glycans.	Jers C, Michalak M, Larsen DM, Kepp KP, Li H, Guo Y, Kirpekar F, Meyer AS, Mikkelsen JD.	PLoS One	10.1371/journal.pone.0083902	2014
	Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis.	Xu X, Jia X, Mo L, Liu C, Zheng L, Yuan Q, Zhou X.	Bone Res	10.1038/boneres.2017.46	2017
	Microbiota and neurologic diseases: potential effects of probiotics.	Umbrello G, Esposito S.	J Transl Med	10.1186/s12967-016-1058-7	2016
Metabolism	Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling.	Ishizuka T, Kanmani P, Kobayashi H, Miyazaki A, Soma J, Suda Y, Aso H, Nochi T, Iwabuchi N, Xiao JZ, Saito T, Villena J, Kitazawa H.	PLoS One	10.1371/journal.pone.0152416	2016
Metabolism	In Vitro Fermentation of caprine milk oligosaccharides by bifidobacteria isolated from breast-fed infants.	Thum C, Roy NC, McNabb WC, Otter DE, Cookson AL.	Gut Microbes	10.1080/19490976.2015.1105425	2015
	Effect of the EM Bokashi® Multimicrobial Probiotic Preparation on the Non-specific Immune Response in Pigs.	Laskowska E, Jarosz LS, Gradzki Z.	Probiotics Antimicrob Proteins	10.1007/s12602-018-9460-5	2019
	Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.	Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, Yang HT, Tancredi DJ, German JB, Slupsky CM, Ashwood P, Mills DA, Smilowitz JT, Angkustsiri K.	PLoS One	10.1371/journal.pone.0210064	2019
	Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study.	Nieto-Ruiz A, Garcia-Santos JA, Verdejo-Roman J, Dieguez E, Sepulveda-Valbuena N, Herrmann F, Cerdo T, De-Castellar R, Jimenez J, Bermudez MG, Perez-Garcia M, Miranda MT, Lopez-Sabater MC, Catena A, Campoy C.	Front Nutr	10.3389/fnut.2022.820224	2022
	Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study.	Quagliariello A, Aloisio I, Bozzi Cionci N, Luiselli D, D'Auria G, Martinez-Priego L, Perez-Villarroya D, Langerholc T, Primec M, Micetic-Turk D, Di Gioia D.	Nutrients	10.3390/nu8100660	2016
	Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 9: suitability of taxonomic units notified to EFSA until September 2018.	EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis K, Allende A, Alvarez-Ordonez A, Bolton D, Bover-Cid S, Chemaly M, Davies R, Hilbert F, Lindqvist R, Nauta M, Peixe L, Ru G, Simmons M, Skandamis P, Suffredini E, Cocconcelli PS, Fernandez Escamez PS, Maradona MP, Querol A, Suarez JE, Sundh I, Vlak J, Barizzone F, Correia S, Herman L.	EFSA J	10.2903/j.efsa.2019.5555	2019
Metabolism	The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1beta-induced inflammation in human fetal enterocytes via toll receptors 2 and 4.	Jiang F, Meng D, Weng M, Zhu W, Wu W, Kasper D, Walker WA.	PLoS One	10.1371/journal.pone.0172738	2017
	Probiotic modulation of dendritic cell function is influenced by ageing.	You J, Dong H, Mann ER, Knight SC, Yaqoob P.	Immunobiology	10.1016/j.imbio.2013.08.012	2014
	Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies.	Chen L, Li J, Zhu W, Kuang Y, Liu T, Zhang W, Chen X, Peng C.	Front Microbiol	10.3389/fmicb.2020.589726	2020
	Structural determination and daily variations of porcine milk oligosaccharides.	Tao N, Ochonicky KL, German JB, Donovan SM, Lebrilla CB.	J Agric Food Chem	10.1021/jf100398u	2010
	Probiotics against airway allergy: host factors to consider.	Spacova I, Ceuppens JL, Seys SF, Petrova MI, Lebeer S.	Dis Model Mech	10.1242/dmm.034314	2018
	The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.	Salem I, Ramser A, Isham N, Ghannoum MA.	Front Microbiol	10.3389/fmicb.2018.01459	2018
	A comparison of two probiotic strains of bifidobacteria in premature infants.	Underwood MA, Kalanetra KM, Bokulich NA, Lewis ZT, Mirmiran M, Tancredi DJ, Mills DA.	J Pediatr	10.1016/j.jpeds.2013.07.017	2013
	Food in an evolutionary context: insights from mother's milk.	Hinde K, German JB.	J Sci Food Agric	10.1002/jsfa.5720	2012
	Bifidobacterium infantis 35624 protects against salmonella-induced reductions in digestive enzyme activity in mice by attenuation of the host inflammatory response.	Symonds EL, O'Mahony C, Lapthorne S, O'Mahony D, Sharry JM, O'Mahony L, Shanahan F.	Clin Transl Gastroenterol	10.1038/ctg.2012.9	2012
	Inhibitory effect of Bifidobacterium infantis-mediated sKDR prokaryotic expression system on angiogenesis and growth of Lewis lung cancer in mice.	Li ZJ, Zhu H, Ma BY, Zhao F, Mao SH, Liu TG, He JP, Deng LC, Yi C, Huang Y.	BMC Cancer	10.1186/1471-2407-12-155	2012
Pathogenicity	Irritable bowel syndrome: a concise review of current treatment concepts.	Wall GC, Bryant GA, Bottenberg MM, Maki ED, Miesner AR.	World J Gastroenterol	10.3748/wjg.v20.i27.8796	2014
Pathogenicity	Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms.	Konieczna P, Ferstl R, Ziegler M, Frei R, Nehrbass D, Lauener RP, Akdis CA, O'Mahony L.	PLoS One	10.1371/journal.pone.0062617	2013
	Milk bioactives may manipulate microbes to mediate parent-offspring conflict.	Allen-Blevins CR, Sela DA, Hinde K.	Evol Med Public Health	10.1093/emph/eov007	2015
Pathogenicity	Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut.	Groeger D, O'Mahony L, Murphy EF, Bourke JF, Dinan TG, Kiely B, Shanahan F, Quigley EM.	Gut Microbes	10.4161/gmic.25487	2013
	Probiotics: from bench to market.	Klein M, Sanders ME, Duong T, Young HA.	Ann N Y Acad Sci	10.1111/j.1749-6632.2010.05839.x	2010
Genetics	Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii.	Loux V, Mariadassou M, Almeida S, Chiapello H, Hammani A, Buratti J, Gendrault A, Barbe V, Aury JM, Deutsch SM, Parayre S, Madec MN, Chuat V, Jan G, Peterlongo P, Azevedo V, Le Loir Y, Falentin H.	BMC Genomics	10.1186/s12864-015-1467-7	2015
	New and Emerging Treatment Options for Irritable Bowel Syndrome.	Lacy BE, Chey WD, Lembo AJ.	Gastroenterol Hepatol (N Y)		2015
Pathogenicity	Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease.	Corridoni D, Chapman T, Ambrose T, Simmons A.	Front Med (Lausanne)	10.3389/fmed.2018.00032	2018
Genetics	Therapeutical use of probiotic formulations in clinical practice.	Iannitti T, Palmieri B.	Clin Nutr	10.1016/j.clnu.2010.05.004	2010
Pathogenicity	Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms.	Newton DF, Macfarlane S, Macfarlane GT.	Antimicrob Agents Chemother	10.1128/aac.00079-13	2013
	Genetic characterization of the Bifidobacterium breve UCC 2003 hrcA locus.	Ventura M, Canchaya C, Bernini V, Del Casale A, Dellaglio F, Neviani E, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.71.12.8998-9007.2005	2005
Genetics	Development of Real-Time PCR Assay to Specifically Detect 22 Bifidobacterium Species and Subspecies Using Comparative Genomics.	Kim HB, Kim E, Yang SM, Lee S, Kim MJ, Kim HY.	Front Microbiol	10.3389/fmicb.2020.02087	2020
	Comparison of Real-Time PCR and Droplet Digital PCR for the Quantitative Detection of Lactiplantibacillus plantarum subsp. plantarum	Choi CH, Kim E, Yang SM, Kim DS, Suh SM, Lee GY, Kim HY.	Foods	10.3390/foods11091331	2022
	Efficient Biosynthesis of Theanderose, a Potent Prebiotic, Using Amylosucrase from Deinococcus deserti.	Kang JU, So YS, Kim G, Lee W, Seo DH, Shin H, Yoo SH.	J Agric Food Chem	10.1021/acs.jafc.4c05763	2024
Phylogeny	Identification and Monitoring of Lactobacillus delbrueckii Subspecies Using Pangenomic-Based Novel Genetic Markers.	Kim E, Cho EJ, Yang SM, Kim HY.	J Microbiol Biotechnol	10.4014/jmb.2009.09034	2021
	Deciphering the anti-obesity mechanisms of pharmabiotic probiotics through advanced multiomics analysis.	Kim YR, Choi TR, Jo SH, Song WS, Kim T, Kim MG, Baek JH, Kwon SY, Choi BG, Seo SW, Jang CS, Yang YH, Kim YG.	iScience	10.1016/j.isci.2025.111890	2025
Genetics	Differentiation of Lacticaseibacillus zeae Using Pan-Genome Analysis and Real-Time PCR Method Targeting a Unique Gene.	Kim E, Yang SM, Kim HY.	Foods	10.3390/foods10092112	2021
	Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis.	Jadhav A, Jagtap S, Vyavahare S, Sharbidre A, Kunchiraman B.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1268041	2023
Metabolism	The Pleiotropic Effects of Carbohydrate-Mediated Growth Rate Modifications in Bifidobacterium longum NCC 2705.	Duboux S, Pruvost S, Joyce C, Bogicevic B, Muller JA, Mercenier A, Kleerebezem M.	Microorganisms	10.3390/microorganisms11030588	2023
	Analysis of gene expression of bifidobacteria using as the reporter an anaerobic fluorescent protein	Montenegro-Rodriguez C, Peiroten A, Sanchez-Jimenez A, Arques JL, Landete JM.	Biotechnol Lett		2015
Metabolism	Analysis of gene expression of bifidobacteria using as the reporter an anaerobic fluorescent protein.	Montenegro-Rodriguez C, Peiroten A, Sanchez-Jimenez A, Arques JL, Landete JM.	Biotechnol Lett	10.1007/s10529-015-1802-8	2015
	Anaerobic green fluorescent protein as a marker of Bifidobacterium strains.	Landete JM, Peiroten A, Rodriguez E, Margolles A, Medina M, Arques JL.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2014.01.008	2014
	Recent Development of Probiotic Bifidobacteria for Treating Human Diseases.	Chen J, Chen X, Ho CL.	Front Bioeng Biotechnol	10.3389/fbioe.2021.770248	2021
	The Probiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Bifidobacterium animalis subsp. lactis BPL6 Reduces Pathogen Loads and Improves Gut Health of Weaned Piglets Orally Challenged with Salmonella Typhimurium.	Barba-Vidal E, Castillejos L, Roll VFB, Cifuentes-Orjuela G, Moreno Munoz JA, Martin-Orue SM.	Front Microbiol	10.3389/fmicb.2017.01570	2017
	Viability of Probiotic Microorganisms and the Effect of Their Addition to Fruit and Vegetable Juices.	Maia MS, Domingos MM, de Sao Jose JFB.	Microorganisms	10.3390/microorganisms11051335	2023
	Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics.	Yadav MK, Kumari I, Singh B, Sharma KK, Tiwari SK.	Appl Microbiol Biotechnol	10.1007/s00253-021-11646-8	2022
	Application of probiotic bacteria in ginsenoside bioconversion and enhancing its health-promoting benefits: a review.	Vasquez R, Song JH, Park YS, Paik HD, Kang DK.	Food Sci Biotechnol	10.1007/s10068-024-01734-6	2025
	2'-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum.	Du J, Yang H.	Curr Res Food Sci	10.1016/j.crfs.2025.100975	2025
	Microbial interactions and the homeostasis of the gut microbiome: the role of Bifidobacterium.	Martin AJM, Serebrinsky-Duek K, Riquelme E, Saa PA, Garrido D.	Microbiome Res Rep	10.20517/mrr.2023.10	2023
	Feasibility of Using Seaweed (Gracilaria coronopifolia) Synbiotic as a Bioactive Material for Intestinal Health.	Li PH, Lu WC, Chan YJ, Zhao YP, Nie XB, Jiang CX, Ji YX.	Foods	10.3390/foods8120623	2019
	Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius.	Lai CH, Wu SR, Pang JC, Ramireddy L, Chiang YC, Lin CK, Tsen HY.	J Food Drug Anal	10.1016/j.jfda.2016.10.004	2017
	Heterologous Expression and Characterization of Cellouronate (beta-1,4-Glucuronan) Lyase from a Human Intestinal Bacterium Bacteroides luhongzhouii.	Tanaka Y, Matsumura K, Ariga M, Konno N, Ogata M, Habu N.	J Appl Glycosci (1999)	10.5458/jag.7203102	2025
	An improved temperature-sensitive shuttle vector system for scarless gene deletion in human-gut-associated Bifidobacterium species.	Kozakai T, Nakajima A, Miyazawa K, Sasaki Y, Odamaki T, Katoh T, Fukuma T, Xiao JZ, Suzuki T, Katayama T, Sakanaka M.	iScience	10.1016/j.isci.2024.111080	2024
	Methionine utilization by bifidobacteria: possible existence of a reverse transsulfuration pathway.	Wada M, Fukiya S, Suzuki A, Matsumoto N, Matsuo M, Yokota A.	Biosci Microbiota Food Health	10.12938/bmfh.2020-031	2021
	RNA-Based Anti-Inflammatory Effects of Membrane Vesicles Derived from Lactiplantibacillus plantarum.	Yamasaki-Yashiki S, Kawashima F, Saika A, Hosomi R, Kunisawa J, Katakura Y.	Foods	10.3390/foods13060967	2024
	Adhesion mechanisms of Bifidobacterium animalis subsp. lactis JCM 10602 to dietary fiber.	Taniguchi M, Nambu M, Katakura Y, Yamasaki-Yashiki S.	Biosci Microbiota Food Health	10.12938/bmfh.2020-003	2021
Metabolism	Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter.	Yoshida K, Hirano R, Sakai Y, Choi M, Sakanaka M, Kurihara S, Iino H, Xiao JZ, Katayama T, Odamaki T.	Commun Biol	10.1038/s42003-021-02072-7	2021
	Species- and Age/Generation-Dependent Adherence of Bifidobacterium bifidum to Human Intestinal Mucus In Vitro.	Harata G, Yoda K, Wang R, Miyazawa K, Sato M, He F, Endo A.	Microorganisms	10.3390/microorganisms9030542	2021
Enzymology	Characterization of a novel beta-L-arabinofuranosidase in Bifidobacterium longum: functional elucidation of a DUF1680 protein family member.	Fujita K, Takashi Y, Obuchi E, Kitahara K, Suganuma T.	J Biol Chem	10.1074/jbc.m113.528711	2014
	Novel Insights into the Molecular Mechanisms Underlying Robustness and Stability in Probiotic Bifidobacteria.	Schopping M, Goel A, Jensen K, Faria RA, Franzen CJ, Zeidan AA.	Appl Environ Microbiol	10.1128/aem.00082-23	2023
Enzymology	Characterization of a novel beta-L-Arabinofuranosidase in Bifidobacterium longum: functional elucidation of A DUF1680 family member.	Fujita K, Takashi Y, Obuchi E, Kitahara K, Suganuma T.	J Biol Chem	10.1074/jbc.m111.248690	2011
	Gut Microbiota and Bipolar Disorder: An Overview on a Novel Biomarker for Diagnosis and Treatment.	Lucidi L, Pettorruso M, Vellante F, Di Carlo F, Ceci F, Santovito MC, Di Muzio I, Fornaro M, Ventriglio A, Tomasetti C, Valchera A, Gentile A, Kim YK, Martinotti G, Fraticelli S, Di Giannantonio M, De Berardis D.	Int J Mol Sci	10.3390/ijms22073723	2021
Enzymology	Molecular cloning and characterization of a beta-L-Arabinobiosidase in Bifidobacterium longum that belongs to a novel glycoside hydrolase family.	Fujita K, Sakamoto S, Ono Y, Wakao M, Suda Y, Kitahara K, Suganuma T.	J Biol Chem	10.1074/jbc.m110.190512	2011
	Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells.	Ogita T, Nakashima M, Morita H, Saito Y, Suzuki T, Tanabe S.	J Biomed Biotechnol	10.1155/2011/378417	2011
	Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses.	Ventura M, Canchaya C, Zink R, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.70.10.6197-6209.2004	2004
	Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies.	Hudson LE, Anderson SE, Corbett AH, Lamb TJ.	Clin Microbiol Rev	10.1128/cmr.00049-16	2017
	Two-component signal transduction systems in oral bacteria.	Mattos-Graner RO, Duncan MJ.	J Oral Microbiol	10.1080/20002297.2017.1400858	2017
	Gene structure and transcriptional organization of the dnaK operon of Bifidobacterium breve UCC 2003 and application of the operon in bifidobacterial tracing.	Ventura M, Zink R, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.71.1.487-500.2005	2005
	The ClgR protein regulates transcription of the clpP operon in Bifidobacterium breve UCC 2003.	Ventura M, Zhang Z, Cronin M, Canchaya C, Kenny JG, Fitzgerald GF, van Sinderen D.	J Bacteriol	10.1128/jb.187.24.8411-8426.2005	2005
Pathogenicity	The mechanism of probiotic action of human milk N-glycome towards B. infantis ATCC 15697 and identification of the principal functional components.	Mao H, Li S, Yin B, Lin X, Guo J, Wang T, Voglmeir J, Liu L	Food Chem	10.1016/j.foodchem.2022.132532	2022
Phylogeny	Phylogenetic, Functional and Safety Features of 1950s B. infantis Strains.	Duboux S, Ngom-Bru C, De Bruyn F, Bogicevic B	Microorganisms	10.3390/microorganisms10020203	2022
Pathogenicity	Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile.	Hirano R, Sakanaka M, Yoshimi K, Sugimoto N, Eguchi S, Yamauchi Y, Nara M, Maeda S, Ami Y, Gotoh A, Katayama T, Iida N, Kato T, Ohno H, Fukiya S, Yokota A, Nishimoto M, Kitaoka M, Nakai H, Kurihara S	Gut Microbes	10.1080/19490976.2021.1973835	2021
	A postbiotic consisting of heat-treated lactobacilli has a bifidogenic effect in pure culture and in human fermented faecal communities.	Warda AK, Clooney AG, Ryan F, de Almeida Bettio PH, Di Benedetto G, Ross RP, Hill C	Appl Environ Microbiol	10.1128/AEM.02459-20	2021
Metabolism	Generating a fucose permease deletion mutant in Bifidobacterium longum subspecies infantis ATCC 15697.	Higgins MA, Ryan KS	Anaerobe	10.1016/j.anaerobe.2021.102320	2021
Biotechnology	Riboflavin Biosynthesis and Overproduction by a Derivative of the Human Gut Commensal Bifidobacterium longum subsp. infantis ATCC 15697.	Solopova A, Bottacini F, Venturi Degli Esposti E, Amaretti A, Raimondi S, Rossi M, van Sinderen D	Front Microbiol	10.3389/fmicb.2020.573335	2020
Metabolism	Strain-specific strategies of 2'-fucosyllactose, 3-fucosyllactose, and difucosyllactose assimilation by Bifidobacterium longum subsp. infantis Bi-26 and ATCC 15697.	Zabel BE, Gerdes S, Evans KC, Nedveck D, Singles SK, Volk B, Budinoff C	Sci Rep	10.1038/s41598-020-72792-z	2020
Pathogenicity	A Whey Fraction Rich in Immunoglobulin G Combined with Bifidobacterium longum subsp. infantis ATCC 15697 Exhibits Synergistic Effects against Campylobacter jejuni.	Quinn EM, Kilcoyne M, Walsh D, Joshi L, Hickey RM	Int J Mol Sci	10.3390/ijms21134632	2020
	Bifidobacterium longum subsp. infantis ATCC 15697 and Goat Milk Oligosaccharides Show Synergism In Vitro as Anti-Infectives against Campylobacter jejuni.	Quinn EM, Slattery H, Walsh D, Joshi L, Hickey RM	Foods	10.3390/foods9030348	2020
Metabolism	1,6-alpha-L-Fucosidases from Bifidobacterium longum subsp. infantis ATCC 15697 Involved in the Degradation of Core-fucosylated N -Glycan.	Ashida H, Fujimoto T, Kurihara S, Nakamura M, Komeno M, Huang Y, Katayama T, Kinoshita T, Takegawa K	J Appl Glycosci (1999)	10.5458/jag.jag.JAG-2019_0016	2020
Metabolism	Structural Identity of Galactooligosaccharide Molecules Selectively Utilized by Single Cultures of Probiotic Bacterial Strains.	Boger M, van Leeuwen SS, Lammerts van Bueren A, Dijkhuizen L	J Agric Food Chem	10.1021/acs.jafc.9b05968	2019
Genetics	Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients.	Rong H, Xie XH, Zhao J, Lai WT, Wang MB, Xu D, Liu YH, Guo YY, Xu SX, Deng WF, Yang QF, Xiao L, Zhang YL, He FS, Wang S, Liu TB	J Psychiatr Res	10.1016/j.jpsychires.2019.03.017	2019
	Mining Milk for Factors which Increase the Adherence of Bifidobacterium longum subsp. infantis to Intestinal Cells.	Quinn EM, Slattery H, Thompson AP, Kilcoyne M, Joshi L, Hickey RM	Foods	10.3390/foods7120196	2018
Biotechnology	Use of design of experiments to optimize the production of microbial probiotic biofilms.	Speranza B, Liso A, Corbo MR	PeerJ	10.7717/peerj.4826	2018
Metabolism	Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli.	Thongaram T, Hoeflinger JL, Chow J, Miller MJ	J Dairy Sci	10.3168/jds.2017-12753	2017
Enzymology	Recent advances in immobilization strategies for glycosidases.	Karav S, Cohen JL, Barile D, de Moura Bell JM	Biotechnol Prog	10.1002/btpr.2385	2016
Metabolism	Functional characterization of a novel beta-fructofuranosidase from Bifidobacterium longum subsp. infantis ATCC 15697 on structurally diverse fructans.	Avila-Fernandez A, Cuevas-Juarez E, Rodriguez-Alegria ME, Olvera C, Lopez-Munguia A	J Appl Microbiol	10.1111/jam.13154	2016
Metabolism	Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria.	Karav S, Le Parc A, Leite Nobrega de Moura Bell JM, Frese SA, Kirmiz N, Block DE, Barile D, Mills DA	Appl Environ Microbiol	10.1128/AEM.00547-16	2016
Metabolism	Deciphering bifidobacterial-mediated metabolic interactions and their impact on gut microbiota by a multi-omics approach.	Turroni F, Milani C, Duranti S, Mancabelli L, Mangifesta M, Viappiani A, Lugli GA, Ferrario C, Gioiosa L, Ferrarini A, Li J, Palanza P, Delledonne M, van Sinderen D, Ventura M	ISME J	10.1038/ismej.2015.236	2016
Pathogenicity	Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response.	Van Beek AA, Hoogerland JA, Belzer C, De Vos P, De Vos WM, Savelkoul HF, Leenen PJ	Benef Microbes	10.3920/BM2015.0094	2015
Metabolism	Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.	Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA	Sci Rep	10.1038/srep13517	2015
Enzymology	Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697.	Averina O, Alekseeva M, Shkoporov A, Danilenko V	Anaerobe	10.1016/j.anaerobe.2015.07.007	2015
Enzymology	A novel endo-beta-N-acetylglucosaminidase releases specific N-glycans depending on different reaction conditions.	Parc AL, Karav S, De Moura Bell JMLN, Frese SA, Liu Y, Mills DA, Block DE, Barile D	Biotechnol Prog	10.1002/btpr.2133	2015
Enzymology	Comparing substrate specificity of two UDP-sugar pyrophosphorylases and efficient one-pot enzymatic synthesis of UDP-GlcA and UDP-GalA.	Guo Y, Fang J, Li T, Li X, Ma C, Wang X, Wang PG, Li L	Carbohydr Res	10.1016/j.carres.2015.04.001	2015
Pathogenicity	Enzymatic production of HMO mimics by the sialylation of galacto-oligosaccharides.	Wang Y, Jiang K, Ma H, Zeng W, Wang PG, Yao N, Han W, Cheng J, Wang W	Food Chem	10.1016/j.foodchem.2015.02.064	2015
Metabolism	Multi-functional glycoside hydrolase: Blon_0625 from Bifidobacterium longum subsp. infantis ATCC 15697.	Matsumoto T, Shimada S, Hata Y, Tanaka T, Kondo A	Enzyme Microb Technol	10.1016/j.enzmictec.2014.10.001	2014
Pathogenicity	Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 favorably modulates gut microbiota and reduces circulating endotoxins in F344 rats.	Rodes L, Saha S, Tomaro-Duchesneau C, Prakash S	Biomed Res Int	10.1155/2014/602832	2014
Metabolism	Distinct substrate specificities of three glycoside hydrolase family 42 beta-galactosidases from Bifidobacterium longum subsp. infantis ATCC 15697.	Viborg AH, Katayama T, Abou Hachem M, Andersen MC, Nishimoto M, Clausen MH, Urashima T, Svensson B, Kitaoka M	Glycobiology	10.1093/glycob/cwt104	2013
Metabolism	Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules.	Miyauchi E, Ogita T, Miyamoto J, Kawamoto S, Morita H, Ohno H, Suzuki T, Tanabe S	PLoS One	10.1371/journal.pone.0079735	2013
Enzymology	Enrichment of Bifidobacterium longum subsp. infantis ATCC 15697 within the human gut microbiota using alginate-poly-L-lysine-alginate microencapsulation oral delivery system: an in vitro analysis using a computer-controlled dynamic human gastrointestinal model.	Rodes L, Tomaro-Duchesneau C, Saha S, Paul A, Malhotra M, Marinescu D, Shao W, Kahouli I, Prakash S	J Microencapsul	10.3109/02652048.2013.834990	2013
Pathogenicity	Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.	Kavanaugh DW, O'Callaghan J, Butto LF, Slattery H, Lane J, Clyne M, Kane M, Joshi L, Hickey RM	PLoS One	10.1371/journal.pone.0067224	2013
Metabolism	Antimicrobial potential for the combination of bovine lactoferrin or its hydrolysate with lactoferrin-resistant probiotics against foodborne pathogens.	Chen PW, Jheng TT, Shyu CL, Mao FC	J Dairy Sci	10.3168/jds.2012-6112	2013
Phylogeny	Isolation of a bifidogenic peptide from the pepsin hydrolysate of bovine lactoferrin.	Oda H, Wakabayashi H, Yamauchi K, Sato T, Xiao JZ, Abe F, Iwatsuki K	Appl Environ Microbiol	10.1128/AEM.03343-12	2013
Metabolism	Utilization of galactooligosaccharides by Bifidobacterium longum subsp. infantis isolates.	Garrido D, Ruiz-Moyano S, Jimenez-Espinoza R, Eom HJ, Block DE, Mills DA	Food Microbiol	10.1016/j.fm.2012.10.003	2012
Pathogenicity	Identification and accurate quantitation of biological oligosaccharide mixtures.	Strum JS, Kim J, Wu S, De Leoz ML, Peacock K, Grimm R, German JB, Mills DA, Lebrilla CB	Anal Chem	10.1021/ac301128s	2012
Enzymology	A highly efficient galactokinase from Bifidobacterium infantis with broad substrate specificity.	Li L, Liu Y, Wang W, Cheng J, Zhao W, Wang P	Carbohydr Res	10.1016/j.carres.2012.04.022	2012
Metabolism	Novel phytases from Bifidobacterium pseudocatenulatum ATCC 27919 and Bifidobacterium longum subsp. infantis ATCC 15697.	Tamayo-Ramos JA, Sanz-Penella JM, Yebra MJ, Monedero V, Haros M	Appl Environ Microbiol	10.1128/AEM.00782-12	2012
Metabolism	Release and utilization of N-acetyl-D-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis.	Garrido D, Ruiz-Moyano S, Mills DA	Anaerobe	10.1016/j.anaerobe.2012.04.012	2012
Enzymology	Bifidobacterium longum subsp. infantis ATCC 15697 alpha-fucosidases are active on fucosylated human milk oligosaccharides.	Sela DA, Garrido D, Lerno L, Wu S, Tan K, Eom HJ, Joachimiak A, Lebrilla CB, Mills DA	Appl Environ Microbiol	10.1128/AEM.06762-11	2011
Metabolism	Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria.	Asakuma S, Hatakeyama E, Urashima T, Yoshida E, Katayama T, Yamamoto K, Kumagai H, Ashida H, Hirose J, Kitaoka M	J Biol Chem	10.1074/jbc.M111.248138	2011
Metabolism	Substrate promiscuity of N-acetylhexosamine 1-kinases.	Li Y, Yu H, Chen Y, Lau K, Cai L, Cao H, Tiwari VK, Qu J, Thon V, Wang PG, Chen X	Molecules	10.3390/molecules16086396	2011
Metabolism	Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization.	LoCascio RG, Desai P, Sela DA, Weimer B, Mills DA	Appl Environ Microbiol	10.1128/AEM.00675-10	2010
Genetics	The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.	Sela DA, Chapman J, Adeuya A, Kim JH, Chen F, Whitehead TR, Lapidus A, Rokhsar DS, Lebrilla CB, German JB, Price NP, Richardson PM, Mills DA	Proc Natl Acad Sci U S A	10.1073/pnas.0809584105	2008
Metabolism	Myo-inositol hexakisphosphate degradation by Bifidobacterium infantis ATCC 15697.	Haros M, Bielecka M, Honke J, Sanz Y	Int J Food Microbiol	10.1016/j.ijfoodmicro.2007.02.021	2007
Pathogenicity	Growth inhibition of intestinal bacteria and mutagenicity of 2-, 3-, 4-aminobiphenyls, benzidine, and biphenyl.	Chung KT, Adris P	Toxicol In Vitro	10.1016/s0887-2333(02)00131-5	2003
Enzymology	Characterization of a purified beta-fructofuranosidase from Bifidobacterium infantis ATCC 15697.	Warchol M, Perrin S, Grill JP, Schneider F	Lett Appl Microbiol	10.1046/j.1472-765x.2002.01224.x	2002
Metabolism	Cholesterol assimilation by lactic acid bacteria and bifidobacteria isolated from the human gut.	Pereira DI, Gibson GR	Appl Environ Microbiol	10.1128/AEM.68.9.4689-4693.2002	2002
Metabolism	Fermentations of fructo-oligosaccharides and their components by Bifidobacterium infantis ATCC 15697 on batch culture in semi-synthetic medium.	Perrin S, Warchol M, Grill JP, Schneider F	J Appl Microbiol	10.1046/j.1365-2672.2001.01317.x	2001
Enzymology	Intra- and extracellular beta-galactosidases from Bifidobacterium bifidum and B. infantis: molecular cloning, heterologous expression, and comparative characterization.	Moller PL, Jorgensen F, Hansen OC, Madsen SM, Stougaard P	Appl Environ Microbiol	10.1128/AEM.67.5.2276-2283.2001	2001
	Survival of bifidobacteria in yogurt and simulated gastric juice following immobilization in gellan-xanthan beads.	Sun W, Griffiths MW	Int J Food Microbiol	10.1016/s0168-1605(00)00327-5	2000
Metabolism	Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria.	Chung KT, Lu Z, Chou MW	Food Chem Toxicol	10.1016/s0278-6915(98)00086-6	1998
Pathogenicity	Effect of bifidogenic factors on growth characteristics of bifidobacteria in infant formulas.	Dubey UK, Mistry VV	J Dairy Sci	10.3168/jds.S0022-0302(96)76469-X	1996
Pathogenicity	Growth characteristics of bifidobacteria in infant formulas.	Dubey UK, Mistry VV	J Dairy Sci	10.3168/jds.S0022-0302(96)76468-8	1996
Phylogeny	Isolation and structural analysis of polysaccharide containing galactofuranose from the cell walls of Bifidobacterium infantis.	Tone-Shimokawa Y, Toida T, Kawashima T	J Bacteriol	10.1128/jb.178.1.317-320.1996	1996
Pathogenicity	Current status of melanoma treatment with interferon, cytokines and other biologic response modifiers in Japan.	Ishihara K, Hayasaka K, Yamazaki N	J Invest Dermatol	10.1111/1523-1747.ep13076752	1989
Stress	Characterizing the release of bioactive N-glycans from dairy products by a novel endo-beta-N-acetylglucosaminidase.	Karav S, Bell JM, Le Parc A, Liu Y, Mills DA, Block DE, Barile D	Biotechnol Prog	10.1002/btpr.2135	2015
Metabolism	Release of bifidogenic N-glycans from native bovine colostrum proteins by an endo-beta-N-acetylglucosaminidase.	Bunyatratchata A, Parc AL, de Moura Bell JMLN, Cohen JL, Duman H, Arslan A, Kaplan M, Barile D, Karav S	Enzyme Microb Technol	10.1016/j.enzmictec.2022.110138	2022
Phylogeny	Bifidobacterium callitrichidarum sp. nov. from the faeces of the emperor tamarin (Saguinus imperator).	Modesto M, Michelini S, Sansosti MC, De Filippo C, Cavalieri D, Qvirist L, Andlid T, Spiezio C, Sandri C, Pascarelli S, Sgorbati B, Mattarelli P.	Int J Syst Evol Microbiol	10.1099/ijsem.0.002472	2018
Phylogeny	Five novel bifidobacterial species isolated from faeces of primates in two Czech zoos: Bifidobacterium erythrocebi sp. nov., Bifidobacterium moraviense sp. nov., Bifidobacterium oedipodis sp. nov., Bifidobacterium olomucense sp. nov. and Bifidobacterium panos sp. nov.	Neuzil-Bunesova V, Lugli GA, Modrackova N, Vlkova E, Bolechova P, Burtscher J, Longhi G, Mancabelli L, Killer J, Domig K, Ventura M	Int J Syst Evol Microbiol	10.1099/ijsem.0.004573	2020
Phylogeny	Bifidobacterium eulemuris sp. nov., isolated from faeces of black lemurs (Eulemur macaco).	Michelini S, Modesto M, Pisi AM, Filippini G, Sandri C, Spiezio C, Biavati B, Sgorbati B, Mattarelli P	Int J Syst Evol Microbiol	10.1099/ijsem.0.000924	2016
Phylogeny	Proposal to reclassify the three biotypes of Bifidobacterium longum as three subspecies: Bifidobacterium longum subsp. longum subsp. nov., Bifidobacterium longum subsp. infantis comb. nov. and Bifidobacterium longum subsp. suis comb. nov.	Mattarelli P, Bonaparte C, Pot B, Biavati B	Int J Syst Evol Microbiol	10.1099/ijs.0.65319-0	2008

References

#8514	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20088
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#37702	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68382	Automatically annotated from API zym .
#120651	Collection of Institut Pasteur ; Curators of the CIP; CIP 64.67
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Bifidobacterium longum subsp. infantis (DSM 20088, ATCC 15697, NCTC 11817)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Murein

Metabolite utilization

Metabolite production

Enzymes

API zym

API 50CHac

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Genome sequences

Genome browser: GCA_000020425

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