Bifidobacterium longum subsp. infantis (DSM 20218, ATCC 17930, JCM 1260)

Name: Bifidobacterium longum subsp. infantis (DSM 20218, ATCC 17930, JCM 1260)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 1745

Type strain

Culture col. no. DSM 20218 ATCC 17930 JCM 1260 BCRC 14661

NCBI tax ID(s) 1682

Special Collections DSMZ JCM

Links

Bifidobacterium longum subsp. infantis DSM 20218 is an anaerobe, mesophilic prokaryote that was isolated from Baby feces.

anaerobe mesophilic 16S sequence

Name and taxonomic classification

SI-ID 9640

LMG 11588,ATCC 17930,DSM 20218,LMG 13205,JCM 1260,CCRC 14661,KCTC 3473,BCRC 14661

@ref 20215

Last LPSN update 2025-12-16 09:47:10

Domain Bacillati

Phylum Actinomycetota

Class Actinomycetes

Order Bifidobacteriales

Family Bifidobacteriaceae

Genus Bifidobacterium

Species Bifidobacterium longum subsp. infantis

Full scientific name Bifidobacterium longum subsp. infantis (Reuter 1963) Mattarelli et al. 2008

Synonyms (1)

Bifidobacterium infantis

BacDive ID	Other strains from **Bifidobacterium longum subsp. infantis** (24)	Type strain
1743	B. longum subsp. infantis S12, DSM 20088, ATCC 15697, NCTC 11817, JCM ... (type strain)
1744	B. longum subsp. infantis S76E, DSM 20090, ATCC 15702, JCM 1272, BCRC ...
143274	B. longum subsp. infantis CCUG 18157, LMG 18912
146680	B. longum subsp. infantis CCUG 31778
148902	B. longum subsp. infantis CCUG 36569
151518	B. longum subsp. infantis CCUG 44191
152130	B. longum subsp. infantis CCUG 45868
152264	B. longum subsp. infantis CCUG 46247
152772	B. longum subsp. infantis CCUG 47592
154127	B. longum subsp. infantis CCUG 52484
154128	B. longum subsp. infantis CCUG 52485
154129	B. longum subsp. infantis CCUG 52486
154130	B. longum subsp. infantis CCUG 52487
155385	B. longum subsp. infantis CCUG 57566
159328	B. longum subsp. infantis WCA-178-WT-4B, DSM 107246
161155	B. longum subsp. infantis JCM 11344
161156	B. longum subsp. infantis JCM 11345
161157	B. longum subsp. infantis JCM 11347
161180	B. longum subsp. infantis JCM 11660, CGMCC 1.3006
161197	B. longum subsp. infantis JCM 1210, ATCC 25962, BCRC 14603, CECT 4552, ...
165449	B. longum subsp. infantis JCM 7007, LMG 18901
165450	B. longum subsp. infantis JCM 7009, LMG 18902
165451	B. longum subsp. infantis JCM 7010
165452	B. longum subsp. infantis JCM 7011

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
8611	BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)		Medium recipe at MediaDive	Name: BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58) Composition: Glucose 10.0 g/l Casein peptone 10.0 g/l Bacto Soytone 5.0 g/l Meat extract 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l MnSO4 x H2O 0.05 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Tween 80 Resazurin Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
8611	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

8611

Oxygen toleranceanaerobe

Murein

@ref	Murein short key	Type
8611	A21.03	A3ß L-Orn-L-Ser-L-Ala-L-Thr-L-Ala

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	+	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	+	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	+	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	+	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	+	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	+	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	+	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	+	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
8611	-	-	-	+	-	+	+	-	-	-	+	+	+	+	-	-	-	+	-	-	-	+	+	-	-	+	-	+/-	+	+	+	+	-	-	-	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-

Isolation, sampling and environmental information

Isolation

67770

Sample typeBaby feces

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8611	1	Risk group (German classification) According to TRBA 466

Sequence information

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Bifidobacterium longum subsp. infantis gene for 16S rRNA, partial sequence, strain: JCM 1260	AB116306	471	1682
20218	Bifidobacterium longum gene for 16S rRNA, partial sequence, strain: JCM 1260	AB507103	655	216816
124043	Bifidobacterium longum subsp. infantis gene for 16S ribosomal RNA, partial sequence, strain: YIT 12735.	AB924520	1504	1682

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Galacto- and Fructo-oligosaccharides Utilized for Growth by Cocultures of Bifidobacterial Species Characteristic of the Infant Gut.	Sims IM, Tannock GW.	Appl Environ Microbiol	10.1128/aem.00214-20	2020
Metabolism	tuf Gene Sequence Variation in Bifidobacterium longum subsp. infantis Detected in the Fecal Microbiota of Chinese Infants.	Lawley B, Centanni M, Watanabe J, Sims I, Carnachan S, Broadbent R, Lee PS, Wong KH, Tannock GW.	Appl Environ Microbiol	10.1128/aem.00336-18	2018
	The dual role for probiotics use in dental practices.	Goff DA, McFarland LV, Johnson S, Goff DW.	Front Oral Health	10.3389/froh.2023.1336565	2023
Phylogeny	Phylogenetic, Functional and Safety Features of 1950s B. infantis Strains.	Duboux S, Ngom-Bru C, De Bruyn F, Bogicevic B.	Microorganisms	10.3390/microorganisms10020203	2022
Metabolism	Bifidobacterium infantis utilizes N-acetylglucosamine-containing human milk oligosaccharides as a nitrogen source.	Li S, You X, Rani A, Ozcan E, Sela DA.	Gut Microbes	10.1080/19490976.2023.2244721	2023
	Draft Genome Sequence of Bifidobacterium longum ZJ1, Isolated from a Centenarian in Anhui, China.	Jin Z, Li W, Wang W, Sun B.	Microbiol Resour Announc	10.1128/mra.00878-19	2019
Metabolism	In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds.	Yun EJ, Yu S, Kim YA, Liu JJ, Kang NJ, Jin YS, Kim KH.	Mar Drugs	10.3390/md19040213	2021
	Potential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas.	Duman H, Kaplan M, Arslan A, Sahutoglu AS, Kayili HM, Frese SA, Karav S.	Front Nutr	10.3389/fnut.2021.646275	2021
	Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ.	Fan X, Zhou Y, Bai W, Li X, Lin L, Lin H, Yang M, Yu X, Wang J, Lin L, Wang W.	Proc Natl Acad Sci U S A	10.1073/pnas.2415845122	2025
	Prebiotic potential of Agave angustifolia Haw fructans with different degrees of polymerization.	Velazquez-Martinez JR, Gonzalez-Cervantes RM, Hernandez-Gallegos MA, Mendiola RC, Aparicio AR, Ocampo ML.	Molecules	10.3390/molecules190812660	2014
	Prebiotic and Functional Fibers from Micro- and Macroalgae: Gut Microbiota Modulation, Health Benefits, and Food Applications.	Deniz N, Saritas S, Bechelany M, Karav S.	Int J Mol Sci	10.3390/ijms262211082	2025
Metabolism	Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.	Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA.	Sci Rep	10.1038/srep13517	2015
	Establishment of intestinal bacteriology.	Mitsuoka T.	Biosci Microbiota Food Health	10.12938/bmfh.33.99	2014
	Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies.	Andrade JC, Almeida D, Domingos M, Seabra CL, Machado D, Freitas AC, Gomes AM.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00550	2020
Metabolism	Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants.	Wang A, Diana A, Rahmannia S, Gibson RS, Houghton LA, Slupsky CM.	Gut Microbes	10.1080/19490976.2023.2257273	2023
Biotechnology	A Human Gut Commensal Ferments Cranberry Carbohydrates To Produce Formate.	Ozcan E, Sun J, Rowley DC, Sela DA.	Appl Environ Microbiol	10.1128/aem.01097-17	2017
Metabolism	Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization.	LoCascio RG, Desai P, Sela DA, Weimer B, Mills DA.	Appl Environ Microbiol	10.1128/aem.00675-10	2010
Metabolism	Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation.	Sakanaka M, Gotoh A, Yoshida K, Odamaki T, Koguchi H, Xiao JZ, Kitaoka M, Katayama T.	Nutrients	10.3390/nu12010071	2019
Metabolism	A versatile and scalable strategy for glycoprofiling bifidobacterial consumption of human milk oligosaccharides.	Locascio RG, Ninonuevo MR, Kronewitter SR, Freeman SL, German JB, Lebrilla CB, Mills DA.	Microb Biotechnol	10.1111/j.1751-7915.2008.00072.x	2009
Pathogenicity	Breast milk urea as a nitrogen source for urease positive Bifidobacterium infantis.	Schimmel P, Kleinjans L, Bongers RS, Knol J, Belzer C	FEMS Microbiol Ecol	10.1093/femsec/fiab019	2021

References

#8611	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20218
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Bifidobacterium longum subsp. infantis (DSM 20218, ATCC 17930, JCM 1260)

Name and taxonomic classification

Morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Murein

Metabolite utilization

API 50CHac

Isolation, sampling and environmental information

Isolation

Interaction and safety

Risk assessment

Sequence information

16S sequences

Genome-based predictions

Literature

Literature

References

BacDive

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