Aggregatibacter actinomycetemcomitans B5279 is a facultative anaerobe, mesophilic, Gram-negative prokaryote of the family Pasteurellaceae.
Gram-negative rod-shaped facultative anaerobe mesophilic genome sequence 16S sequence| @ref 20215 |
Last LPSN update
2025-12-16 10:02:54 |
| Domain Pseudomonadati |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Aggregatibacter |
| Species Aggregatibacter actinomycetemcomitans |
| Full scientific name Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 |
| Synonyms (3) |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 27613 ChEBI | amygdalin | - | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | - | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68377 | 15824 ChEBI | D-fructose | + | builds acid from | from API NH |
| 68371 | 15824 ChEBI | D-fructose | - | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | - | builds acid from | from API 50CH acid |
| 68377 | 17634 ChEBI | D-glucose | + | builds acid from | from API NH |
| 68371 | 17634 ChEBI | D-glucose | - | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | - | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 68371 | 4853 ChEBI | esculin | - | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | - | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | - | builds acid from | from API 50CH acid |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17716 ChEBI | lactose | - | builds acid from | from API 50CH acid |
| 68377 | 17306 ChEBI | maltose | + | builds acid from | from API NH |
| 68371 | 17306 ChEBI | maltose | - | builds acid from | from API 50CH acid |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 28053 ChEBI | melibiose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 38769 | 17632 ChEBI | nitrate | + | reduction | |
| 38769 | 16301 ChEBI | nitrite | - | reduction | |
| 68377 | 18257 ChEBI | ornithine | - | degradation | from API NH |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | 16634 ChEBI | raffinose | - | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | - | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | - | builds acid from | from API 50CH acid |
| 68371 | 17992 ChEBI | sucrose | - | builds acid from | from API 50CH acid |
| 68377 | 17992 ChEBI | sucrose | - | builds acid from | from API NH |
| 68371 | 27082 ChEBI | trehalose | - | builds acid from | from API 50CH acid |
| 68377 | 27897 ChEBI | tryptophan | - | energy source | from API NH |
| 68371 | 32528 ChEBI | turanose | - | builds acid from | from API 50CH acid |
| 68377 | 16199 ChEBI | urea | - | hydrolysis | from API NH |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68377 | alkaline phosphatase | + | 3.1.3.1 | from API NH |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68377 | beta-galactosidase | - | 3.2.1.23 | from API NH |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | + | 3.2.1.31 | from API zym |
| 68377 | beta-lactamase | - | 3.5.2.6 | from API NH |
| 38769 | catalase | + | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68377 | gamma-glutamyltransferase | + | 2.3.2.2 | from API NH |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68377 | lipase | - | from API NH | |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 68377 | ornithine decarboxylase | - | 4.1.1.17 | from API NH |
| 38769 | oxidase | - | ||
| 68377 | proline-arylamidase | - | 3.4.11.5 | from API NH |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68377 | tryptophan deaminase | - | 4.1.99.1 | from API NH |
| 38769 | urease | - | 3.5.1.5 | |
| 68377 | urease | - | 3.5.1.5 | from API NH |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 38769 | not determinedn.d. | - | - | - | - | - | - | - | - | - | - | - | - | +/- | - | - | - | - | - | - | - | - | +/- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | +/- |
| Cat1 | Cat2 | Cat3 | |
|---|---|---|---|
| #Host Body-Site | #Other | #Bone | |
| #Host Body-Site | #Oral cavity and airways | #Mouth | |
| #Host Body-Site | #Other | #Wound | |
| #Host | #Human | - |
Global distribution of 16S sequence M75036 (>99% sequence identity) for Aggregatibacter actinomycetemcomitans subclade from Microbeatlas 
 Aquatic Samples |
279 |
 Soil Samples |
46 |
 Animal Samples |
7969 |
 Plant Samples |
42 |
| Total Samples | 8336 |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 66792 | ASM2355964v1 assembly for Aggregatibacter actinomycetemcomitans ATCC 29522 | contig | GCA_023559645   | 714.783  | 714 | 73.67 | |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 67770 | Aggregatibacter actinomycetemcomitans gene for 16S rRNA, partial sequence, strain: JCM 2434 | AB594758 | 1462 | | 714 | |
| 67770 | Aggregatibacter actinomycetemcomitans strain ATCC 29522 16S ribosomal RNA gene, partial sequence | M75036 | 1479 | | 714 | |
| 124043 | Actinobacillus actinomycetemcomitans ATCC 29522 16S rRNA and 23S rRNA genes, partial sequence, 16S-23S spacer and tRNA-Glu gene, complete sequence. | U07778 | 396 | | 714 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Efficacy of Four Herbal Extracts on Actinobacillus Actinomycetemcomitans and Prophyromonas Gingivalis: an in vitro microbiological study. | Kafle D, Humagain M, Luintel S, Karki A, Lamichhane J. | Kathmandu Univ Med J (KUMJ) | 2024 | | ||
| Chemical characterization and antimicrobial activities of Citrus aurantifolia peel oils and Ocimum sanctum ethanolic extract. | Duangsombat P, Waranuch N, Pitaksuteepong T. | PLoS One | 10.1371/journal.pone.0331710 | 2025 | | |
| Combined potential of copaifera officinalis oleoresin and chitosan against oral pathogens. | Gomes TV, de Oliveira MS, Polo AB, Tome BV, Cardoso MM, Tavares GD, Apolonio ACM. | Braz J Microbiol | 10.1007/s42770-024-01523-7 | 2024 | | |
| Multimodal inhibitory effect of matcha on Porphyromonas gingivalis. | Nakao R, Takatsuka A, Mandokoro K, Narisawa N, Ikeda T, Takai H, Ogata Y. | Microbiol Spectr | 10.1128/spectrum.03426-23 | 2024 | | |
| Pathogenicity | Human Coronary Artery Endothelial Cell Response to Porphyromonas gingivalis W83 in a Collagen Three-Dimensional Culture Model. | Cardona-Mendoza A, Roa Molina NS, Castillo DM, Lafaurie GI, Gualtero Escobar DF. | Microorganisms | 10.3390/microorganisms12020248 | 2024 | |
| Proteome | Connections between Exoproteome Heterogeneity and Virulence in the Oral Pathogen Aggregatibacter actinomycetemcomitans. | Fu Y, Maab S, du Teil Espina M, Wolters AHG, Gong Y, de Jong A, Raangs E, Buist G, Westra J, Becher D, van Dijl JM. | mSystems | 10.1128/msystems.00254-22 | 2022 | |
| Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment. | Ancuta DL, Alexandru DM, Muselin F, Cristina RT, Coman C. | Int J Mol Sci | 10.3390/ijms25105432 | 2024 | | |
| Streptococcus salivarius as an Important Factor in Dental Biofilm Homeostasis: Influence on Streptococcus mutans and Aggregatibacter actinomycetemcomitans in Mixed Biofilm. | Begic G, Badovinac IJ, Karleusa L, Kralik K, Cvijanovic Peloza O, Kuis D, Gobin I. | Int J Mol Sci | 10.3390/ijms24087249 | 2023 | | |
| Induction of Experimental Peri-Implantitis with Strains Selected from the Human Oral Microbiome. | Ancuta DL, Alexandru DM, Crivineanu M, Coman C. | Biomedicines | 10.3390/biomedicines12040715 | 2024 | | |
| Effects of Green Tea Extract Epigallocatechin-3-Gallate on Oral Diseases: A Narrative Review. | Li Y, Cheng L, Li M. | Pathogens | 10.3390/pathogens13080634 | 2024 | | |
| Moxifloxacin HCl-Incorporated Aqueous-Induced Nitrocellulose-Based In Situ Gel for Periodontal Pocket Delivery. | Senarat S, Rojviriya C, Sarunyakasitrin K, Charoentreeraboon J, Pichayakorn W, Phaechamud T. | Gels | 10.3390/gels9070572 | 2023 | | |
| Galleria mellonella as an experimental model for studying periodontopathogens. | Santos TA, Scorzoni L, Santos AC, Junqueira JC, Anbinder AL. | J Indian Soc Periodontol | 10.4103/jisp.jisp_631_19 | 2020 | | |
| A Comparative Analysis of the Efficacy of Bacterial Lysate versus Antibiotic Therapy in the Treatment of Experimental Peri-Implantitis in Rats. | Ancuta DL, Alexandru DM, Tucureanu C, Coman C. | Microorganisms | 10.3390/microorganisms12081537 | 2024 | | |
| In Vitro Antimicrobial Effect of Novel Electrospun Polylactic Acid/Hydroxyapatite Nanofibres Loaded with Doxycycline. | Andrei V, Fit NI, Matei I, Barabas R, Bizo LA, Cadar O, Bosca BA, Farkas NI, Marincas L, Muntean DM, Dinte E, Ilea A. | Materials (Basel) | 10.3390/ma15186225 | 2022 | | |
| Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis. | Okano T, Ashida H, Komatsu N, Tsukasaki M, Iida T, Iwasawa M, Takahashi Y, Takeuchi Y, Iwata T, Sasai M, Yamamoto M, Takayanagi H, Suzuki T. | Int J Oral Sci | 10.1038/s41368-024-00315-x | 2024 | | |
| Induction of Periodontitis Using Bacterial Strains Isolated from the Human Oral Microbiome in an Experimental Rat Model. | Ancuta DL, Alexandru DM, Crivineanu M, Coman C. | Biomedicines | 10.3390/biomedicines11082098 | 2023 | | |
| Proteome | Differential Virulence of Aggregatibacter actinomycetemcomitans Serotypes Explained by Exoproteome Heterogeneity. | Fu Y, Maab S, Cavallo FM, de Jong A, Raangs E, Westra J, Buist G, Becher D, van Dijl JM. | Microbiol Spectr | 10.1128/spectrum.03298-22 | 2023 | |
| Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment. | Senarat S, Tuntarawongsa S, Lertsuphotvanit N, Rojviriya C, Phaechamud T, Chantadee T. | Gels | 10.3390/gels9070583 | 2023 | | |
| Physicochemical and Bioactivity Characteristics of Doxycycline Hyclate-Loaded Solvent Removal-Induced Ibuprofen-Based In Situ Forming Gel. | Puyathorn N, Senarat S, Lertsuphotvanit N, Phaechamud T. | Gels | 10.3390/gels9020128 | 2023 | | |
| Photosensitized Methylene Blue Nanoparticles: A Promising Approach for the Control of Oral Infections. | Parizzi M, Almeida AR, Salvador G, Dominguini D, Fernandes M, Becker D, Nunes MR, Masiero AV, da Rosa CG. | Biomedicines | 10.3390/biomedicines13030673 | 2025 | | |
| Skin secretions of Leptodactylidae (Anura) and their potential applications. | Carrillo JFC, Boaretto AG, Santana DJ, Silva DB. | J Venom Anim Toxins Incl Trop Dis | 10.1590/1678-9199-jvatitd-2023-0042 | 2024 | | |
| Silver-deposited titanium as a prophylactic 'nano coat' for peri-implantitis. | Madiwal V, Rajwade J. | Nanoscale Adv | 10.1039/d3na00898c | 2024 | | |
| Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment. | Lertsuphotvanit N, Tuntarawongsa S, Chantadee T, Phaechamud T. | Gels | 10.3390/gels9070557 | 2023 | | |
| Curry Leaf Triggers Cell Death of P. gingivalis with Membrane Blebbing. | Nakao R, Ikeda T, Furukawa S, Morinaga Y. | Pathogens | 10.3390/pathogens10101286 | 2021 | | |
| Enhanced antibacterial activity and superior biocompatibility of cobalt-deposited titanium discs for possible use in implant dentistry. | Madiwal V, Khairnar B, Rajwade J. | iScience | 10.1016/j.isci.2024.108827 | 2024 | | |
| Differential analysis of culturable and unculturable subgingival target microorganisms according to the stages of periodontitis. | Lafaurie GI, Castillo DM, Iniesta M, Sanz M, Gomez LA, Castillo Y, Pianeta R, Delgadillo NA, Neuta Y, Diaz-Baez D, Herrera D. | Clin Oral Investig | 10.1007/s00784-023-04907-5 | 2023 | | |
| Pathogenicity | A polyphenolic cinnamon fraction exhibits anti-inflammatory properties in a monocyte/macrophage model. | Ben Lagha A, Azelmat J, Vaillancourt K, Grenier D. | PLoS One | 10.1371/journal.pone.0244805 | 2021 | |
| Assessing Antimicrobial Efficacy on Plastics and Other Non-Porous Surfaces: A Closer Look at Studies Using the ISO 22196:2011 Standard. | Bento de Carvalho T, Barbosa JB, Teixeira P. | Biology (Basel) | 10.3390/biology13010059 | 2024 | | |
| Assessment of the antimicrobial efficacy of hydroalcoholic fruit extract of cranberry against Socransky complexes and predominant cariogenic, mycotic and endodontic climax communities of the oral cavity: An extensive in-vitro study. | Kumar V, Ankola AV, Sankeshwari R, Jalihal S, Deepak V, Jois HS. | J Oral Maxillofac Pathol | 10.4103/jomfp.jomfp_3_18 | 2019 | | |
| Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel Against Porphyromonas gingivalis. | Yoshino N, Ikeda T, Nakao R. | Front Microbiol | 10.3389/fmicb.2022.816047 | 2022 | | |
| Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review. | Gualtero DF, Lafaurie GI, Buitrago DM, Castillo Y, Vargas-Sanchez PK, Castillo DM. | Front Cardiovasc Med | 10.3389/fcvm.2023.1250263 | 2023 | | |
| Metabolism | Aggregatibacter actinomycetemcomitans Invasion Induces Interleukin-1beta Production Through Reactive Oxygen Species and Cathepsin B. | Okinaga T, Ariyoshi W, Nishihara T. | J Interferon Cytokine Res | 10.1089/jir.2014.0127 | 2015 | |
| O-Polysaccharide Plays a Major Role on the Virulence and Immunostimulatory Potential of Aggregatibacter actinomycetemcomitans During Periodontal Infection. | Monasterio G, Castillo F, Astorga J, Hoare A, Terraza-Aguirre C, Cafferata EA, Villablanca EJ, Vernal R. | Front Immunol | 10.3389/fimmu.2020.591240 | 2020 | | |
| Differential effects of five Aggregatibacter actinomycetemcomitans strains on gingival epithelial cells. | Shimada T, Sugano N, Nishihara R, Suzuki K, Tanaka H, Ito K. | Oral Microbiol Immunol | 10.1111/j.1399-302x.2008.00449.x | 2008 | | |
| Quebecol Shows Potential to Alleviate Periodontal Tissue Damage and Promote Bone Formation in In Vitro Models. | Cardinal S, Ben Lagha A, Azelmat J, Grenier D. | ACS Omega | 10.1021/acsomega.1c03312 | 2021 | | |
| Probiotic Species in the Management of Periodontal Diseases: An Overview. | Zhang Y, Ding Y, Guo Q. | Front Cell Infect Microbiol | 10.3389/fcimb.2022.806463 | 2022 | | |
| Pathogenicity | The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria. | Haag PA, Steiger-Ronay V, Schmidlin PR. | Int J Mol Sci | 10.3390/ijms161126027 | 2015 | |
| Pathogenicity | Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response. | Ben Lagha A, LeBel G, Grenier D. | BMC Complement Altern Med | 10.1186/s12906-017-2072-x | 2018 | |
| Adhesion of Oral Bacteria to Commercial d-PTFE Membranes: Polymer Microstructure Makes a Difference. | Begic G, Petkovic Didovic M, Lucic Blagojevic S, Jelovica Badovinac I, Zigon J, Percic M, Cvijanovic Peloza O, Gobin I. | Int J Mol Sci | 10.3390/ijms23062983 | 2022 | | |
| Antimicrobial photodynamic activity and cytocompatibility of Au25(Capt)18 clusters photoexcited by blue LED light irradiation. | Miyata S, Miyaji H, Kawasaki H, Yamamoto M, Nishida E, Takita H, Akasaka T, Ushijima N, Iwanaga T, Sugaya T. | Int J Nanomedicine | 10.2147/ijn.s131602 | 2017 | | |
| Metabolism | NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice. | Bast A, Kubis H, Holtfreter B, Ribback S, Martin H, Schreiner HC, Dominik MJ, Breitbach K, Dombrowski F, Kocher T, Steinmetz I. | Infect Immun | 10.1128/iai.00849-16 | 2017 | |
| Selective bacterial degradation of the extracellular matrix attaching the gingiva to the tooth. | Fouillen A, Grenier D, Barbeau J, Baron C, Moffatt P, Nanci A. | Eur J Oral Sci | 10.1111/eos.12623 | 2019 | | |
| Composition and Antibacterial Activity of the Essential Oils of Orthosiphon stamineus Benth and Ficus deltoidea Jack against Pathogenic Oral Bacteria. | Azizan N, Mohd Said S, Zainal Abidin Z, Jantan I. | Molecules | 10.3390/molecules22122135 | 2017 | | |
| Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity. | Bagameri L, Baci GM, Dezmirean DS. | Pharmaceutics | 10.3390/pharmaceutics14061142 | 2022 | | |
| Production of poly-beta-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces. | van Dissel D, Willemse J, Zacchetti B, Claessen D, Pier GB, van Wezel GP. | Microb Cell | 10.15698/mic2018.06.635 | 2018 | | |
| Metabolism | Quantitative discrimination of Aggregatibacter actinomycetemcomitans highly leukotoxic JP2 clone from non-JP2 clones in diagnosis of aggressive periodontitis. | Yoshida A, Ennibi OK, Miyazaki H, Hoshino T, Hayashida H, Nishihara T, Awano S, Ansai T. | BMC Infect Dis | 10.1186/1471-2334-12-253 | 2012 | |
| Pathogenicity | A new functional site W115 in CdtA is critical for Aggregatibacter actinomycetemcomitans cytolethal distending toxin. | Li L, Ding C, Duan JL, Yang MF, Sun Y, Wang XQ, Xu Y. | PLoS One | 10.1371/journal.pone.0065729 | 2013 | |
| Enzymology | Prevalence and distribution of Aggregatibacter actinomycetemcomitans and its cdtB gene in subgingival plaque of Chinese periodontitis patients. | Wang X, Li L, Yang M, Geng Y, Chen H, Xu Y, Sun Y. | BMC Oral Health | 10.1186/1472-6831-14-37 | 2014 | |
| Magnolol ameliorates ligature-induced periodontitis in rats and osteoclastogenesis: in vivo and in vitro study. | Lu SH, Huang RY, Chou TC. | Evid Based Complement Alternat Med | 10.1155/2013/634095 | 2013 | | |
| Association between periodontal disease and plasma levels of cholesterol and triglycerides. | Jaramillo A, Lafaurie GI, Millan LV, Ardila CM, Duque A, Novoa C, Lopez D, Contreras A. | Colomb Med (Cali) | 10.25100/cm.v44i2.1123 | 2013 | | |
| Enzymology | Bacteriological analysis of necrotic pulp and fistulae in primary teeth. | Fabris AS, Nakano V, Avila-Campos MJ. | J Appl Oral Sci | 10.1590/1678-775720130358 | 2014 | |
| Enzymology | PCR detection of Streptococcus mutans and Aggregatibacter actinomycetemcomitans in dental plaque samples from Haitian adolescents. | Psoter WJ, Ge Y, Russell SL, Chen Z, Katz RV, Jean-Charles G, Li Y. | Clin Oral Investig | 10.1007/s00784-010-0413-y | 2011 | |
| Pathogenicity | Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier. | Bottino MC, Munchow EA, Albuquerque MTP, Kamocki K, Shahi R, Gregory RL, Chu TG, Pankajakshan D. | J Biomed Mater Res B Appl Biomater | 10.1002/jbm.b.33743 | 2017 | |
| Pathogenicity | Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions. | Mary C, Fouillen A, Moffatt P, Guadarrama Bello D, Wazen RM, Grenier D, Nanci A. | Sci Rep | 10.1038/s41598-021-02661-w | 2021 | |
| Pathogenicity | Synergistic anti-inflammatory activity of the antimicrobial peptides human beta-defensin-3 (hBD-3) and cathelicidin (LL-37) in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts. | Bedran TB, Mayer MP, Spolidorio DP, Grenier D. | PLoS One | 10.1371/journal.pone.0106766 | 2014 | |
| Metabolism | Black Tea Extract and Its Theaflavin Derivatives Inhibit the Growth of Periodontopathogens and Modulate Interleukin-8 and beta-Defensin Secretion in Oral Epithelial Cells. | Lombardo Bedran TB, Morin MP, Palomari Spolidorio D, Grenier D. | PLoS One | 10.1371/journal.pone.0143158 | 2015 | |
| Pathogenicity | The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties. | Liao J, Azelmat J, Zhao L, Yoshioka M, Hinode D, Grenier D. | Biomed Res Int | 10.1155/2014/436206 | 2014 | |
| Phylogeny | Multivariate chemosystematics demonstrate two groups of Actinobacillus actinomycetemcomitans strains. | Brondz I, Olsen I. | Oral Microbiol Immunol | 10.1111/j.1399-302x.1993.tb00654.x | 1993 | |
| Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study. | Ghizoni JS, Taveira LA, Garlet GP, Ghizoni MF, Pereira JR, Dionisio TJ, Brozoski DT, Santos CF, Sant'Ana AC. | J Appl Oral Sci | 10.1590/s1678-77572012000100019 | 2012 | | |
| Metabolism | Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. | Grenier D, Huot MP, Mayrand D. | Antimicrob Agents Chemother | 10.1128/aac.44.3.763-766.2000 | 2000 | |
| LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo. | Reis PVM, Boff D, Verly RM, Melo-Braga MN, Cortes ME, Santos DM, Pimenta AMC, Amaral FA, Resende JM, de Lima ME. | Front Microbiol | 10.3389/fmicb.2018.00667 | 2018 | | |
| Enzymology | Development of species-specific primers for detection of Streptococcus mutans in mixed bacterial samples. | Chen Z, Saxena D, Caufield PW, Ge Y, Wang M, Li Y. | FEMS Microbiol Lett | 10.1111/j.1574-6968.2007.00756.x | 2007 | |
| DNA inversion on conjugative plasmid pVT745. | Chen J, Leblanc DJ, Galli DM. | J Bacteriol | 10.1128/jb.184.21.5926-5934.2002 | 2002 | | |
| Metabolism | A novel approach for purification and selective capture of membrane vesicles of the periodontopathic bacterium, Porphyromonas gingivalis: membrane vesicles bind to magnetic beads coated with epoxy groups in a noncovalent, species-specific manner. | Nakao R, Kikushima K, Higuchi H, Obana N, Nomura N, Bai D, Ohnishi M, Senpuku H. | PLoS One | 10.1371/journal.pone.0095137 | 2014 | |
| The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease. | Marquis A, Genovese S, Epifano F, Grenier D. | BMC Complement Altern Med | 10.1186/1472-6882-12-80 | 2012 | | |
| Pathogenicity | Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans. | Piccolomini R, Catamo G, Di Bonaventura G. | Antimicrob Agents Chemother | 10.1128/aac.42.11.3000 | 1998 | |
| Phylogeny | Identification of Actinobacillus actinomycetemcomitans serotypes by multiplex PCR. | Suzuki N, Nakano Y, Yoshida Y, Ikeda D, Koga T. | J Clin Microbiol | 10.1128/jcm.39.5.2002-2005.2001 | 2001 | |
| Metabolism | Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans. | Goulhen F, Hafezi A, Uitto VJ, Hinode D, Nakamura R, Grenier D, Mayrand D. | Infect Immun | 10.1128/iai.66.11.5307-5313.1998 | 1998 | |
| Identification of genomic clonal types of Actinobacillus actinomycetemcomitans by restriction endonuclease analysis. | Han N, Hoover CI, Winkler JR, Ng CY, Armitage GC. | J Clin Microbiol | 10.1128/jcm.29.8.1574-1578.1991 | 1991 | | |
| Genetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans. | Wang Y, Liu A, Chen C. | Infect Immun | 10.1128/iai.73.6.3749-3753.2005 | 2005 | | |
| Nucleotide sequence and analysis of conjugative plasmid pVT745. | Galli DM, Chen J, Novak KF, Leblanc DJ. | J Bacteriol | 10.1128/jb.183.5.1585-1594.2001 | 2001 | | |
| Improved multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis. | Tran SD, Rudney JD. | J Clin Microbiol | 10.1128/jcm.37.11.3504-3508.1999 | 1999 | | |
| Genetics | Evaluating two methods for fingerprinting genomes of Actinobacillus actinomycetemcomitans. | Slots J, Liu YB, DiRienzo JM, Chen C. | Oral Microbiol Immunol | 10.1111/j.1399-302x.1993.tb00608.x | 1993 | |
| Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial. | Ramirez JH, Arce RM, Contreras A. | Trials | 10.1186/1745-6215-12-46 | 2011 | | |
| Transformation of Actinobacillus actinomycetemcomitans by electroporation, utilizing constructed shuttle plasmids. | Sreenivasan PK, LeBlanc DJ, Lee LN, Fives-Taylor P. | Infect Immun | 10.1128/iai.59.12.4621-4627.1991 | 1991 | | |
| Phylogeny | Comparison of six typing methods for Actinobacillus actinomycetemcomitans. | van Steenbergen TJ, Bosch-Tijhof CJ, van Winkelhoff AJ, Gmur R, de Graaff J. | J Clin Microbiol | 10.1128/jcm.32.11.2769-2774.1994 | 1994 | |
| Pathogenicity | Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis. | Inubushi T, Kawazoe A, Miyauchi M, Kudo Y, Ao M, Ishikado A, Makino T, Takata T. | J Biol Chem | 10.1074/jbc.m111.324673 | 2012 | |
| Enzymology | Multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. | Tran SD, Rudney JD. | J Clin Microbiol | 10.1128/jcm.34.11.2674-2678.1996 | 1996 | |
| Aae, an autotransporter involved in adhesion of Actinobacillus actinomycetemcomitans to epithelial cells. | Rose JE, Meyer DH, Fives-Taylor PM. | Infect Immun | 10.1128/iai.71.5.2384-2393.2003 | 2003 | | |
| Phylogeny | Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. | Kaplan JB, Schreiner HC, Furgang D, Fine DH. | J Clin Microbiol | 10.1128/jcm.40.4.1181-1187.2002 | 2002 | |
| Immunochemical and structural characterization of a serotype-specific polysaccharide antigen from Actinobacillus actinomycetemcomitans Y4 (serotype b). | Amano K, Nishihara T, Shibuya N, Noguchi T, Koga T. | Infect Immun | 10.1128/iai.57.10.2942-2946.1989 | 1989 | | |
| Enzymology | Detection and strain identification of Actinobacillus actinomycetemcomitans by nested PCR. | Leys EJ, Griffen AL, Strong SJ, Fuerst PA. | J Clin Microbiol | 10.1128/jcm.32.5.1288-1294.1994 | 1994 | |
| Metabolism | Long-term effect of heat shock protein 60 from Actinobacillus actinomycetemcomitans on epithelial cell viability and mitogen-activated protein kinases. | Zhang L, Pelech S, Uitto VJ. | Infect Immun | 10.1128/iai.72.1.38-45.2004 | 2004 | |
| Identification of an immunoglobulin Fc receptor of Actinobacillus actinomycetemcomitans. | Mintz KP, Fives-Taylor PM. | Infect Immun | 10.1128/iai.62.10.4500-4505.1994 | 1994 | | |
| Metabolism | Detection of cytolethal distending toxin activity and cdt genes in Actinobacillus actinomycetemcomitans isolates from geographically diverse populations. | Fabris AS, DiRienzo JM, Wikstrom M, Mayer MP. | Oral Microbiol Immunol | 10.1034/j.1399-302x.2002.170405.x | 2002 | |
| Laser-assisted microbial culturomics. | Qu T, Koch L, Mukherjee R, Tu Y, Seidel AL, Puttmann LD, Winkel A, Yang I, Grischke J, Liu D, Wolkers WF, Kittler S, Chichkov B, Stiesch M, Szafranski SP. | Nat Commun | 10.1038/s41467-025-66804-7 | 2025 | | |
| Enzymology | Evaluation of bacterial adhesion on machined titanium, Osseotite® and Nanotite® discs. | Rodriguez y Baena R, Arciola CR, Selan L, Battaglia R, Imbriani M, Rizzo S, Visai L. | Int J Artif Organs | 10.5301/ijao.5000143 | 2012 | |
| Pathogenicity | In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. | Ikai H, Odashima Y, Kanno T, Nakamura K, Shirato M, Sasaki K, Niwano Y. | PLoS One | 10.1371/journal.pone.0081316 | 2013 | |
| Photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation. | Ikai H, Nakamura K, Shirato M, Kanno T, Iwasawa A, Sasaki K, Niwano Y, Kohno M. | Antimicrob Agents Chemother | 10.1128/aac.00751-10 | 2010 | | |
| Metabolism | Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation. | Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Ortengren U, Sasaki K, Niwano Y. | Sci Rep | 10.1038/s41598-019-41126-z | 2019 | |
| Antibacterial Activity of Myristica fragrans against Oral Pathogens. | Shafiei Z, Shuhairi NN, Md Fazly Shah Yap N, Harry Sibungkil CA, Latip J | Evid Based Complement Alternat Med | 10.1155/2012/825362 | 2012 | | |
| Pathogenicity | Protease-activated receptor 2 mediates interleukin-8 and intercellular adhesion molecule-1 expression in response to Aggregatibacter actinomycetemcomitans. | Shimada T, Sugano N, Ikeda K, Shimada K, Iizuka T, Ito K | Oral Microbiol Immunol | 10.1111/j.1399-302X.2009.00507.x | 2009 | |
| Pathogenicity | Antibacterial effect of zinc phosphate mineralized guided bone regeneration membranes. | Chou AH, LeGeros RZ, Chen Z, Li Y | Implant Dent | 10.1097/ID.0b013e318031224a | 2007 | |
| Enzymology | Parameters associated with cloning in Actinobacillus actinomycetemcomitans. | Galli DM, Kerr MS, Fair AD, Permpanich P, LeBlanc DJ | Plasmid | 10.1006/plas.2001.1556 | 2002 | |
| Enzymology | Detection of antigenic surface proteins of Actinobacillus actinomycetemcomitans using the immunoblotting method. | Mineyama R | Microbios | 2001 | | |
| Pathogenicity | A novel factor isolated from Actinobacillus actinomycetemcomitans stimulates mouse B cells and human peripheral blood mononuclear cells. | Jeong SJ, Yee ST, Jo WS, Yu SH, Lee SH, Lim YJ, Yoo YH, Kim JM, Lee JD, Jeong MH | Infect Immun | 10.1128/IAI.68.9.5132-5138.2000 | 2000 | |
| Pathogenicity | An evaluation of the action of different root canal irrigants on facultative aerobic-anaerobic, obligate anaerobic, and microaerophilic bacteria. | D'Arcangelo C, Varvara G, De Fazio P | J Endod | 10.1016/S0099-2399(06)81170-2 | 1999 | |
| Pathogenicity | The mechanisms of Eikenella corrodens aggregation by salivary glycoprotein and the effect of the glycoprotein on oral bacterial aggregation. | Ebisu S, Nakae H, Fukuhara H, Okada H | J Periodontal Res | 10.1111/j.1600-0765.1992.tb01745.x | 1992 | |
| Enzymology | Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. | Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, Saari H, Uitto VJ | Infect Immun | 10.1128/iai.60.11.4491-4495.1992 | 1992 | |
| Biotechnology | [Mouse interleukin-1 production by Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide and augmenting effect of indomethacin on its production]. | Tsutsui T, Hanazawa S | Meikai Daigaku Shigaku Zasshi | 1990 | | |
| [Chemical structure and immunomodulating activities of peptidoglycan from Actinobacillus actinomycetemcomitans]. | Kinoshita F | Kanagawa Shigaku | 1989 | | ||
| Phylogeny | Differentiation among closely related organisms of the Actinobacillus-Haemophilus-Pasteurella group by means of lysozyme and EDTA. | Olsen I, Brondz I | J Clin Microbiol | 10.1128/jcm.22.4.629-636.1985 | 1985 | |
| Phylogeny | Immunoglobulin G response to subgingival gram-negative bacteria in human subjects. | Naito Y, Okuda K, Takazoe I | Infect Immun | 10.1128/iai.45.1.47-51.1984 | 1984 | |
| Pathogenicity | In vitro antimicrobial susceptibility of periodontopathic Actinobacillus actinomycetemcomitans to roxithromycin and erythromycin. | Piccolomini R, Di Bonaventura G, Catamo G, Picciani C, Paolantonio M | Oral Microbiol Immunol | 10.1111/j.1399-302x.1997.tb00740.x | 1997 | |
| Pathogenicity | Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface. | Ohta H, Hara H, Fukui K, Kurihara H, Murayama Y, Kato K | Infect Immun | 10.1128/iai.61.11.4878-4884.1993 | 1993 | |
| Phylogeny | Phylogeny of 54 representative strains of species in the family Pasteurellaceae as determined by comparison of 16S rRNA sequences. | Dewhirst FE, Paster BJ, Olsen I, Fraser GJ | J Bacteriol | 10.1128/jb.174.6.2002-2013.1992 | 1992 | |
| Enzymology | Chemical composition and immunobiological activities of sodium dodecyl sulphate extracts from the cell envelopes of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Fusobacterium nucleatum. | Kato K, Kokeguchi S, Ishihara H, Murayama Y, Tsujimoto M, Takada H, Ogawa T, Kotani S | J Gen Microbiol | 10.1099/00221287-133-4-1033 | 1987 | |
| Metabolism | Characterization of an inducible bacteriophage from a leukotoxic strain of Actinobacillus actinomycetemcomitans. | Stevens RH, Hammond BF, Lai CH | Infect Immun | 10.1128/iai.35.1.343-349.1982 | 1982 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive137823.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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