Aggregatibacter actinomycetemcomitans A1916 is a bacterium that was isolated from Human blood.
16S sequence Bacteria| @ref 20215 |
|
Last LPSN update
2026-02-09 11:32:59 |
| Domain Bacteria |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Pasteurellales |
| Family Pasteurellaceae |
| Genus Aggregatibacter |
| Species Aggregatibacter actinomycetemcomitans |
| Full scientific name Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 |
| Synonyms (3) |
Global distribution of 16S sequence AB548673 (>99% sequence identity) for Aggregatibacter actinomycetemcomitans subclade from Microbeatlas 
 Aquatic Samples |
282 |
 Soil Samples |
70 |
 Animal Samples |
8180 |
 Plant Samples |
88 |
| Total Samples | 8620 |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 67770 | Aggregatibacter actinomycetemcomitans gene for 16S ribosomal RNA, partial sequence, strin: JCM 12985 | AB548673 | 1501 |  | 714 | |
| 67770 | Aggregatibacter actinomycetemcomitans strain ATCC 29523 16S ribosomal RNA gene, partial sequence | AY362885 | 1362 | | 714 | |
| 124043 | Aggregatibacter actinomycetemcomitans partial 16S rRNA gene, strain HG1223/ATCC29523, serovar A | FN547968 | 1199 | | 714 |  |
| 124043 | Aggregatibacter actinomycetemcomitans strain ATCC 29523 16S ribosomal RNA gene, partial sequence. | M75038 | 1480 | | 714 | |
| 124043 | Actinobacillus actinomycetemcomitans ATCC 29523 16S rRNA gene and 16S-23S spacer, partial sequence, and tRNA-Glu gene, complete sequence. | U07776 | 260 | | 714 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Impact of oral pathogens on inflammatory mediator expression in oral cells. | Hodar PS, Shah M, Fu Y, P Shah P, Haldia A, Agrawal A, Mehta M. | Bioinformation | 10.6026/973206300211506 | 2025 | | |
| In-vitro Evaluation of the Antimicrobial Efficacy of Various Mouth Rinses on Periodontal Pathogens. | Sandhu TPS, Shania, Mukhtar S, Kumari S, Gonabhavi SC, Swathi Koutha VSL. | J Pharm Bioallied Sci | 10.4103/jpbs.jpbs_201_25 | 2025 | | |
| Honey Compounds Exhibit Antibacterial Effects Against Aggregatibacter actinomycetemcomitans JP2. | Hbibi A, Ezzahi A, Ozturk F, Cremers NAJ, Kasouati J, Moussaif A, Johansson A, Zouhdi M, Toure B, Maroui I. | Antibiotics (Basel) | 10.3390/antibiotics14090887 | 2025 | | |
| Linking periodontal pathogens with endoperio lesions. | Malik S, Priyanka KS, Mohanty R, Khader AA, Prasad S, Dey S, Jerry JJ. | Bioinformation | 10.6026/973206300200583 | 2024 | | |
| Effects of initial periodontal therapy on the formation of neutrophil extracellular traps in gingival crevicular fluid in patients with severe periodontitis. | Fu L, Hao X, Qian W, Sun Y. | Hua Xi Kou Qiang Yi Xue Za Zhi | 10.7518/hxkq.2024.2024162 | 2025 | | |
| Silica-based silver nanocomposite 80S/Ag as Aggregatibacter actinomycetemcomitans inhibitor and its in vitro bioactivity. | Kung JC, Yang TY, Hung CC, Shih CJ. | J Dent Sci | 10.1016/j.jds.2023.10.014 | 2024 | | |
| Antibacterial and cytotoxicity properties of a polyherbal mouthwash containing Achyranthes aspera and Trachyspermum ammi against selected periodontal pathogens. | Kumar RS, Ankola AV, Nagamoti MB, Sankeshwari RM, Sutar KP, Jigan SI, Pai Khot AJ. | J Ayurveda Integr Med | 10.1016/j.jaim.2024.101046 | 2024 | | |
| In vitro effects of fibrin hydrogel incorporated with Litsea cubeba essential oil on viability of periodontal pathogens and human gingival fibroblasts. | Khamhan W, Srisatjaluk RL, Pudla M, Ruangsawasdi N, Kuphasuk Y. | J Dent Sci | 10.1016/j.jds.2024.08.019 | 2025 | | |
| Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans. | Tang-Siegel GG, Radermacher M, Mintz KP, Ruiz T. | J Bacteriol | 10.1128/jb.00215-22 | 2022 | | |
| Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial. | Thamaraiselvan M, Jayakumar ND. | J Adv Periodontol Implant Dent | 10.34172/japid.2024.021 | 2024 | | |
| The serotype a-EmaA adhesin of Aggregatibacter actinomycetemcomitans does not require O-PS synthesis for collagen binding activity. | Tang-Siegel GG, Danforth DR, Tristano J, Ruiz T, Mintz KP. | Microbiology (Reading) | 10.1099/mic.0.001191 | 2022 | | |
| Assessment of potential antimicrobial activity of Ocimum basilicum extract and chlorhexidine against Socransky's complex pathogens of oral cavity: An in vitro study. | Khot AJP, Ankola AV, Dodamani S, Sankeshwari RM, Kumar RS, Santhosh VN. | J Indian Soc Periodontol | 10.4103/jisp.jisp_406_22 | 2023 | | |
| Contribution of adhesion proteins to Aggregatibacter actinomycetemcomitans biofilm formation. | Danforth DR, Melloni M, Tristano J, Mintz KP. | Mol Oral Microbiol | 10.1111/omi.12346 | 2021 | | |
| 3-Phenyllactic acid generated in medicinal plant extracts fermented with plant-derived lactic acid bacteria inhibits the biofilm synthesis of Aggregatibacter actinomycetemcomitans. | Shakya S, Danshiitsoodol N, Noda M, Inoue Y, Sugiyama M. | Front Microbiol | 10.3389/fmicb.2022.991144 | 2022 | | |
| Antibacterial Activity of 2-Hydroxyisocaproic Acid (HICA) Against Obligate Anaerobic Bacterial Species Associated With Periodontal Disease. | Sakko M, Rautemaa-Richardson R, Sakko S, Richardson M, Sorsa T. | Microbiol Insights | 10.1177/11786361211050086 | 2021 | | |
| Antibodies to oral pathobionts and colon cancer risk in the CLUE I cohort study. | Debertin J, Teles F, Martin LM, Lu J, Koestler DC, Kelsey KT, Beck JD, Platz EA, Michaud DS. | Int J Cancer | 10.1002/ijc.34527 | 2023 | | |
| Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens. | Araujo LL, Lourenco TGB, Colombo APV. | J Appl Oral Sci | 10.1590/1678-7757-2022-0359 | 2023 | | |
| Pathogenicity | Blood Biomarkers and Serologic Immunological Profiles Related to Periodontitis in Abdominal Aortic Aneurysm Patients. | Salhi L, Rijkschroeff P, Van Hede D, Laine ML, Teughels W, Sakalihasan N, Lambert F. | Front Cell Infect Microbiol | 10.3389/fcimb.2021.766462 | 2021 | |
| In Vitro Bioactivity and Antibacterial Effects of a Silver-Containing Mesoporous Bioactive Glass Film on the Surface of Titanium Implants. | Wang YC, Lin SH, Chien CS, Kung JC, Shih CJ. | Int J Mol Sci | 10.3390/ijms23169291 | 2022 | | |
| A Novel Device for the Evaluation of In Vitro Bacterial Colonization in Membranes for Guided Tissue and Bone Regeneration. | Gil ACK, Merino EAD, Costa DP, Giracca CN, Mazzon R, Magrin GL, de Almeida J, Benfatti CAM. | Dent J (Basel) | 10.3390/dj12070202 | 2024 | | |
| Factors Associated with the Extent of Clinical Attachment Loss in Periodontitis: A Multicenter Cross-Sectional Study. | Lafaurie GI, Sabogal MA, Contreras A, Castillo DM, Gualtero DF, Avila J, Trujillo TG, Duque A, Giraldo A, Duarte S, Gutierrez SJ, Ardila CM. | Int J Environ Res Public Health | 10.3390/ijerph20227043 | 2023 | | |
| Lactobacillus acidophilus impairs the establishment of pathogens in a subgingival multispecies biofilm. | Bueno MR, Dudu-Silva G, Macedo TT, Gomes APAP, Rodrigues Oliveira Braga A, Aguiar Silva LD, Bueno-Silva B. | Front Dent Med | 10.3389/fdmed.2023.1212773 | 2023 | | |
| Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm. | Bueno-Silva B, Parma-Garcia J, Frigo L, Suarez LJ, Macedo TT, Uyeda FH, Melo MARDC, Sacco R, Mourao CF, Feres M, Shibli JA, Figueiredo LC. | Pathogens | 10.3390/pathogens13040342 | 2024 | | |
| Metabolism | A Nonfimbrial Adhesin of Aggregatibacter actinomycetemcomitans Mediates Biofilm Biogenesis. | Danforth DR, Tang-Siegel G, Ruiz T, Mintz KP. | Infect Immun | 10.1128/iai.00704-18 | 2019 | |
| Antimicrobial susceptibility pattern of oral isolates of Aggregatibacter actinomycetemcomitans. | Bhat KG, Khot P, Patil S, Pattar G, Majukar S. | J Oral Maxillofac Pathol | 10.4103/jomfp.jomfp_123_19 | 2019 | | |
| Metabolism | Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. | Pahumunto N, Basic A, Ostberg AK, Teanpaisan R, Dahlen G. | BMC Microbiol | 10.1186/s12866-020-01959-5 | 2020 | |
| Evaluation of role of periodontal pathogens in endodontic periodontal diseases. | Das AC, Sahoo SK, Parihar AS, Bhardwaj SS, Babaji P, Varghese JG. | J Family Med Prim Care | 10.4103/jfmpc.jfmpc_725_19 | 2020 | | |
| In vitro effect of diode laser against biofilm of Aggregatibacter actinomycetemcomitans. | Tantivitayakul P, Rassameemasmaung S, Thapanabhiboonsuk S. | Eur J Dent | 10.4103/ejd.ejd_289_17 | 2018 | | |
| Evaluation of the Microbial Profile on the Polydioxanone Membrane and the Collagen Membrane Exposed to Multi-Species Subgingival Biofilm: An In Vitro Study. | Cintra Moreira MV, Figueiredo LC, da Cunha Melo MAR, Uyeda FH, da Silva LDA, Macedo TT, Sacco R, Mourao CF, Shibli JA, Bueno-Silva B. | Membranes (Basel) | 10.3390/membranes13120907 | 2023 | | |
| Assessment of the antimicrobial efficacy of hydroalcoholic fruit extract of cranberry against Socransky complexes and predominant cariogenic, mycotic and endodontic climax communities of the oral cavity: An extensive in-vitro study. | Kumar V, Ankola AV, Sankeshwari R, Jalihal S, Deepak V, Jois HS. | J Oral Maxillofac Pathol | 10.4103/jomfp.jomfp_3_18 | 2019 | | |
| Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI). | Zhang OL, Niu JY, Yin IX, Yu OY, Mei ML, Chu CH. | Antibiotics (Basel) | 10.3390/antibiotics12091350 | 2023 | | |
| Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1. | Ihalin R, Zhong D, Karched M, Chen C, Asikainen S. | Med Microbiol Immunol | 10.1007/s00430-018-0554-1 | 2018 | | |
| In vitro evaluation of membranes for regenerative procedures against oral bacteria. | Gil ACK, Prado MM, Rocha LRD, Benfatti C, Schuldt Filho G, Almeida J. | Braz Dent J | 10.1590/0103-6440202305060 | 2023 | | |
| Metabolism | Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL. | Kyrklund M, Bildo M, Akhi R, Nissinen AE, Pussinen P, Horkko S, Wang C. | PLoS One | 10.1371/journal.pone.0230682 | 2020 | |
| Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens. | Li X, He P, Yu L, He Q, Jia C, Yang H, Lu M, Wei X, Zhao S. | J Oral Microbiol | 10.1080/20002297.2020.1831374 | 2020 | | |
| Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis. | Liukkonen J, Gursoy UK, Kononen E, Akhi R, Salminen A, Liljestrand JM, Pradhan-Palikhe P, Pietiainen M, Sorsa T, Persson GR, Mantyla P, Buhlin K, Paju S, Sinisalo J, Horkko S, Pussinen PJ. | Diagnostics (Basel) | 10.3390/diagnostics10080560 | 2020 | | |
| Traditionally used herbal medicines with antibacterial effect on Aggegatibacter actinomycetemcomitans: Boswellia serrata and Nigella sativa. | Maraghehpour B, Khayamzadeh M, Najafi S, Kharazifard M. | J Indian Soc Periodontol | 10.4103/jisp.jisp_12_17 | 2016 | | |
| In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens. | Fani M, Kohanteb J. | J Evid Based Complementary Altern Med | 10.1177/2156587217700772 | 2017 | | |
| Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis. | Isola G, Polizzi A, Patini R, Ferlito S, Alibrandi A, Palazzo G. | BMC Oral Health | 10.1186/s12903-020-01258-5 | 2020 | | |
| Pathogenicity | Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm. | Tanaka CJ, Rodrigues JA, Pingueiro JMS, Macedo TT, Feres M, Shibli JA, Bueno-Silva B. | Pharmaceutics | 10.3390/pharmaceutics15061727 | 2023 | |
| Residual decontamination chemical agents negatively affect adhesion and proliferation of osteoblast-like cells on implant surface. | Balderrama IF, Cardoso MV, Stuani VT, Oliveira RC, Matos AA, Greghi SLA, Sant'Ana ACP. | Int J Implant Dent | 10.1186/s40729-020-00278-8 | 2020 | | |
| Rapid synthesis of bismuth-organic frameworks as selective antimicrobial materials against microbial biofilms. | Huang R, Zhou Z, Lan X, Tang FK, Cheng T, Sun H, Cham-Fai Leung K, Li X, Jin L. | Mater Today Bio | 10.1016/j.mtbio.2022.100507 | 2023 | | |
| Determination of antibacterial activity of green coffee bean extract on periodontogenic bacteria like Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans: An in vitro study. | Bharath N, Sowmya NK, Mehta DS. | Contemp Clin Dent | 10.4103/0976-237x.156036 | 2015 | | |
| Pathogenicity | LL-37 opsonizes and inhibits biofilm formation of Aggregatibacter actinomycetemcomitans at subbactericidal concentrations. | Sol A, Ginesin O, Chaushu S, Karra L, Coppenhagen-Glazer S, Ginsburg I, Bachrach G. | Infect Immun | 10.1128/iai.01288-12 | 2013 | |
| Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms. | Figueiredo LC, Freitas Figueiredo N, da Cruz DF, Baccelli GT, Sarachini GE, Bueno MR, Feres M, Bueno-Silva B. | Microorganisms | 10.3390/microorganisms10112172 | 2022 | | |
| Activity of five antimicrobial peptides against periodontal as well as non-periodontal pathogenic strains. | Enigk K, Jentsch H, Rodloff AC, Eschrich K, Stingu CS. | J Oral Microbiol | 10.1080/20002297.2020.1829405 | 2020 | | |
| Serum lipopolysaccharide neutralizing capacity in ischemic stroke. | Leskela J, Pietiainen M, Safer A, Lehto M, Metso J, Malle E, Buggle F, Becher H, Sundvall J, Grau AJ, Pussinen PJ, Palm F. | PLoS One | 10.1371/journal.pone.0228806 | 2020 | | |
| Metabolism | Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts and Porphyromonas gingivalis. | Kyrklund M, Kaski H, Akhi R, Nissinen AE, Kummu O, Bergmann U, Pussinen P, Horkko S, Wang C. | Innate Immun | 10.1177/1753425920981133 | 2021 | |
| Assessment of clinical efficacy of locally delivered 0.2% Thymoquinone gel in the treatment of periodontitis. | Kapil H, Suresh DK, Bathla SC, Arora KS. | Saudi Dent J | 10.1016/j.sdentj.2018.06.001 | 2018 | | |
| Pathogenicity | The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria. | Haag PA, Steiger-Ronay V, Schmidlin PR. | Int J Mol Sci | 10.3390/ijms161126027 | 2015 | |
| Antimicrobial and Anti-inflammatory Lingonberry Mouthwash - A Clinical Pilot Study in the Oral Cavity. | Parnanen P, Nikula-Ijas P, Sorsa T. | Microorganisms | 10.3390/microorganisms7090331 | 2019 | | |
| Enzymology | Association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. | Borgo PV, Rodrigues VA, Feitosa AC, Xavier KC, Avila-Campos MJ. | J Appl Oral Sci | 10.1590/1678-775720140164 | 2014 | |
| Scaling and root planning, and locally delivered minocycline reduces the load of Prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial. | Deng S, Wang Y, Sun W, Chen H, Wu G. | Ther Clin Risk Manag | 10.2147/tcrm.s93982 | 2015 | | |
| Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts. | Ampomah NK, Teles F, Martin LM, Lu J, Koestler DC, Kelsey KT, Beck JD, Platz EA, Michaud DS. | JNCI Cancer Spectr | 10.1093/jncics/pkad029 | 2023 | | |
| [Study of adherence of periodontal pathogens to collagen-treated hydroxyapatite]. | Sun CJ, Yang H, Lei CF, Xu Y, Wu YF. | Hua Xi Kou Qiang Yi Xue Za Zhi | 2008 | | ||
| Brazilian Red Propolis Is as Effective as Amoxicillin in Controlling Red-Complex of Multispecies Subgingival Mature Biofilm In Vitro. | de Figueiredo KA, da Silva HDP, Miranda SLF, Goncalves FJDS, de Sousa AP, de Figueiredo LC, Feres M, Bueno-Silva B. | Antibiotics (Basel) | 10.3390/antibiotics9080432 | 2020 | | |
| Pathogenicity | The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study. | Akca AE, Akca G, Topcu FT, Macit E, Pikdoken L, Ozgen IS. | Biomed Res Int | 10.1155/2016/3627463 | 2016 | |
| Berberine-Functionalized Bismuth-Doped Carbon Dots in a Pathogen-Responsive Hydrogel System: A Multifaceted Approach to Combating Periodontal Diseases. | Li X, Huang R, Li P, Tang FK, He J, Sun H, Wang X, Wang M, Lan X, Wang X, Wong SSW, Jin L, Leung KC, Wong HM, Wang S, Guo L, Ding PH, Yu X. | ACS Nano | 10.1021/acsnano.5c00561 | 2025 | | |
| Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication. | Shibli JA, Rocha TF, Coelho F, de Oliveira Capote TS, Saska S, Melo MA, Pingueiro JMS, de Faveri M, Bueno-Silva B. | Clin Oral Investig | 10.1007/s00784-021-03900-0 | 2021 | | |
| Pathogenicity | Inhibitory activity of green tea (Camellia sinensis) extract on some clinically isolated cariogenic and periodontopathic bacteria. | Araghizadeh A, Kohanteb J, Fani MM. | Med Princ Pract | 10.1159/000348299 | 2013 | |
| Antibacterial and Anti-inflammatory Potential of Morus alba Stem Extract. | Yiemwattana I, Chaisomboon N, Jamdee K. | Open Dent J | 10.2174/1874210601812010265 | 2018 | | |
| Enzymology | Prevalence and distribution of Aggregatibacter actinomycetemcomitans and its cdtB gene in subgingival plaque of Chinese periodontitis patients. | Wang X, Li L, Yang M, Geng Y, Chen H, Xu Y, Sun Y. | BMC Oral Health | 10.1186/1472-6831-14-37 | 2014 | |
| Inhibitory activity of Myrtus communis oil on some clinically isolated oral pathogens. | Fani MM, Kohanteb J, Araghizadeh A. | Med Princ Pract | 10.1159/000362238 | 2014 | | |
| Antibacterial effect of a new haemostatic agent on oral microorganisms. | Cinar C, Odabas ME, Akca G, Isik B. | J Clin Exp Dent | 10.4317/jced.50750 | 2012 | | |
| Short-term microbiological effects of scaling and root planing and essential-oils mouthwash in Chinese adults. | He JY, Qi GG, Huang WJ, Sun XD, Tong Y, Peng CM, Zhou XP, Chen H. | J Zhejiang Univ Sci B | 10.1631/jzus.b1200350 | 2013 | | |
| Conceptual Perspectives: Bacterial Antimicrobial Peptide Induction as a Novel Strategy for Symbiosis with the Human Host. | Ghosh SK, Feng Z, Fujioka H, Lux R, McCormick TS, Weinberg A. | Front Microbiol | 10.3389/fmicb.2018.00302 | 2018 | | |
| Pathogenicity | A Modified Glycosaminoglycan, GM-0111, Inhibits Molecular Signaling Involved in Periodontitis. | Savage JR, Pulsipher A, Rao NV, Kennedy TP, Prestwich GD, Ryan ME, Lee WY. | PLoS One | 10.1371/journal.pone.0157310 | 2016 | |
| Metabolism | Quantitative discrimination of Aggregatibacter actinomycetemcomitans highly leukotoxic JP2 clone from non-JP2 clones in diagnosis of aggressive periodontitis. | Yoshida A, Ennibi OK, Miyazaki H, Hoshino T, Hayashida H, Nishihara T, Awano S, Ansai T. | BMC Infect Dis | 10.1186/1471-2334-12-253 | 2012 | |
| Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria. | Hirschfeld J, White PC, Milward MR, Cooper PR, Chapple ILC. | Infect Immun | 10.1128/iai.00297-17 | 2017 | | |
| Metabolism | Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study. | Michaud DS, Izard J, Rubin Z, Johansson I, Weiderpass E, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Dossus L, Kaaks R, Katzke VA, Boeing H, Foerster J, Trichopoulou A, Naska A, Ziara G, Vineis P, Grioni S, Palli D, Tumino R, Mattiello A, Peeters PH, Siersema PD, Barricarte A, Huerta JM, Molina-Montes E, Dorronsoro M, Quiros JR, Duell EJ, Ohlsson B, Jeppsson B, Johansson A, Lif P, Khaw KT, Wareham N, Travis RC, Key TJ, Freisling H, Duarte-Salles T, Stepien M, Riboli E, Bueno-de-Mesquita HB. | Cancer Causes Control | 10.1007/s10552-013-0265-2 | 2013 | |
| Comparison of serum amyloid A protein and C-reactive protein levels as inflammatory markers in periodontitis. | Ardila CM, Guzman IC. | J Periodontal Implant Sci | 10.5051/jpis.2015.45.1.14 | 2015 | | |
| Oral pathogen aggravates atherosclerosis by inducing smooth muscle cell apoptosis and repressing macrophage efferocytosis. | Xie H, Qin Z, Ling Z, Ge X, Zhang H, Guo S, Liu L, Zheng K, Jiang H, Xu R. | Int J Oral Sci | 10.1038/s41368-023-00232-5 | 2023 | | |
| Artificial neural networks for the diagnosis of aggressive periodontitis trained by immunologic parameters. | Papantonopoulos G, Takahashi K, Bountis T, Loos BG. | PLoS One | 10.1371/journal.pone.0089757 | 2014 | | |
| Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. | Michaud DS, Izard J, Wilhelm-Benartzi CS, You DH, Grote VA, Tjonneland A, Dahm CC, Overvad K, Jenab M, Fedirko V, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Kaaks R, Boeing H, Foerster J, Trichopoulou A, Lagiou P, Trichopoulos D, Sacerdote C, Sieri S, Palli D, Tumino R, Panico S, Siersema PD, Peeters PH, Lund E, Barricarte A, Huerta JM, Molina-Montes E, Dorronsoro M, Quiros JR, Duell EJ, Ye W, Sund M, Lindkvist B, Johansen D, Khaw KT, Wareham N, Travis RC, Vineis P, Bueno-de-Mesquita HB, Riboli E. | Gut | 10.1136/gutjnl-2012-303006 | 2013 | | |
| Pathogenicity | Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis. | Liu R, Memarzadeh K, Chang B, Zhang Y, Ma Z, Allaker RP, Ren L, Yang K. | Sci Rep | 10.1038/srep29985 | 2016 | |
| Bacterial adhesion of Actinobacillus actinomycetemcomitans serotypes to titanium implants: SEM evaluation. A preliminary report. | Okte E, Sultan N, Dogan B, Asikainen S. | J Periodontol | 10.1902/jop.1999.70.11.1376 | 1999 | | |
| Immune response to cytolethal distending toxin of Aggregatibacter actinomycetemcomitans in periodontitis patients. | Ando ES, De-Gennaro LA, Faveri M, Feres M, DiRienzo JM, Mayer MP. | J Periodontal Res | 10.1111/j.1600-0765.2009.01260.x | 2010 | | |
| Genetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans. | Wang Y, Liu A, Chen C. | Infect Immun | 10.1128/iai.73.6.3749-3753.2005 | 2005 | | |
| Association of serum immunoglobulin G (IgG) levels against two periodontal pathogens and prothrombotic state: a clinical pilot study. | Bizzarro S, Nicu EA, van der Velden U, Laine ML, Loos BG. | Thromb J | 10.1186/1477-9560-8-16 | 2010 | | |
| Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan. | Watanabe S, Toyama T, Sato T, Suzuki M, Morozumi A, Sakagami H, Hamada N. | Medicines (Basel) | 10.3390/medicines6010034 | 2019 | | |
| Pathogenicity | In vitro antimicrobial susceptibility of periodontopathic Actinobacillus actinomycetemcomitans to roxithromycin and erythromycin. | Piccolomini R, Di Bonaventura G, Catamo G, Picciani C, Paolantonio M. | Oral Microbiol Immunol | 10.1111/j.1399-302x.1997.tb00740.x | 1997 | |
| Metabolism | Actinobacillus actinomycetemcomitans serotype b lipopolysaccharide mediates coaggregation with Fusobacterium nucleatum. | Rosen G, Nisimov I, Helcer M, Sela MN. | Infect Immun | 10.1128/iai.71.6.3652-3656.2003 | 2003 | |
| The vaginal microflora in relation to gingivitis. | Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D. | BMC Infect Dis | 10.1186/1471-2334-9-6 | 2009 | | |
| Proteolytic Activities of Oral Bacteria on ProMMP-9 and the Effect of Synthetic Proteinase Inhibitors. | Jie Bao G, Kari K, Tervahartiala T, Sorsa T, Meurman JH. | Open Dent J | 10.2174/1874210600802010096 | 2008 | | |
| Phylogeny | Multivariate chemosystematics demonstrate two groups of Actinobacillus actinomycetemcomitans strains. | Brondz I, Olsen I. | Oral Microbiol Immunol | 10.1111/j.1399-302x.1993.tb00654.x | 1993 | |
| Metabolism | Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form. | Karched M, Ihalin R, Eneslatt K, Zhong D, Oscarsson J, Wai SN, Chen C, Asikainen SE. | BMC Microbiol | 10.1186/1471-2180-8-18 | 2008 | |
| Phylogeny | Identification of Actinobacillus actinomycetemcomitans serotypes by multiplex PCR. | Suzuki N, Nakano Y, Yoshida Y, Ikeda D, Koga T. | J Clin Microbiol | 10.1128/jcm.39.5.2002-2005.2001 | 2001 | |
| Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance. | Varela-Lopez A, Navarro-Hortal MD, Giampieri F, Bullon P, Battino M, Quiles JL. | Molecules | 10.3390/molecules23051226 | 2018 | | |
| Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model. | Soares GM, Teles F, Starr JR, Feres M, Patel M, Martin L, Teles R. | Antimicrob Agents Chemother | 10.1128/aac.04974-14 | 2015 | | |
| Pathogenicity | Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens In vitro. | Rovaldi CR, Pievsky A, Sole NA, Friden PM, Rothstein DM, Spacciapoli P. | Antimicrob Agents Chemother | 10.1128/aac.44.12.3364-3367.2000 | 2000 | |
| Pathogenicity | Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans. | Piccolomini R, Catamo G, Di Bonaventura G. | Antimicrob Agents Chemother | 10.1128/aac.42.11.3000 | 1998 | |
| Enzymology | Development of a 5' fluorogenic nuclease-based real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. | Yoshida A, Suzuki N, Nakano Y, Oho T, Kawada M, Koga T. | J Clin Microbiol | 10.1128/jcm.41.2.863-866.2003 | 2003 | |
| Multiserotype enzyme-linked immunosorbent assay as a diagnostic aid for periodontitis in large-scale studies. | Pussinen PJ, Vilkuna-Rautiainen T, Alfthan G, Mattila K, Asikainen S. | J Clin Microbiol | 10.1128/jcm.40.2.512-518.2002 | 2002 | | |
| Metabolism | Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells. | Ouhara K, Komatsuzawa H, Shiba H, Uchida Y, Kawai T, Sayama K, Hashimoto K, Taubman MA, Kurihara H, Sugai M. | Infect Immun | 10.1128/iai.00056-06 | 2006 | |
| Identification of genomic clonal types of Actinobacillus actinomycetemcomitans by restriction endonuclease analysis. | Han N, Hoover CI, Winkler JR, Ng CY, Armitage GC. | J Clin Microbiol | 10.1128/jcm.29.8.1574-1578.1991 | 1991 | | |
| Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface. | Ohta H, Hara H, Fukui K, Kurihara H, Murayama Y, Kato K. | Infect Immun | 10.1128/iai.61.11.4878-4884.1993 | 1993 | | |
| Evidence for apoptosis of murine macrophages by Actinobacillus actinomycetemcomitans infection. | Kato S, Muro M, Akifusa S, Hanada N, Semba I, Fujii T, Kowashi Y, Nishihara T. | Infect Immun | 10.1128/iai.63.10.3914-3919.1995 | 1995 | | |
| Genetics | Evaluating two methods for fingerprinting genomes of Actinobacillus actinomycetemcomitans. | Slots J, Liu YB, DiRienzo JM, Chen C. | Oral Microbiol Immunol | 10.1111/j.1399-302x.1993.tb00608.x | 1993 | |
| Antigenically diverse reference strains and autologous strains of Actinobacillus actinomycetemcomitans are equally efficient antigens in enzyme-linked immunosorbent assay analysis. | Vilkuna-Rautiainen T, Pussinen PJ, Mattila K, Vesanen M, Ahman H, Dogan B, Asikainen S. | J Clin Microbiol | 10.1128/jcm.40.12.4640-4645.2002 | 2002 | | |
| Enzymology | Population-based study of salivary carriage of periodontal pathogens in adults. | Kononen E, Paju S, Pussinen PJ, Hyvonen M, Di Tella P, Suominen-Taipale L, Knuuttila M. | J Clin Microbiol | 10.1128/jcm.02560-06 | 2007 | |
| Phylogeny | Comparison of six typing methods for Actinobacillus actinomycetemcomitans. | van Steenbergen TJ, Bosch-Tijhof CJ, van Winkelhoff AJ, Gmur R, de Graaff J. | J Clin Microbiol | 10.1128/jcm.32.11.2769-2774.1994 | 1994 | |
| Phylogeny | Actinobacillus actinomycetemcomitans serotype d-specific antigen contains the O antigen of lipopolysaccharide. | Lakio L, Paju S, Alfthan G, Tiirola T, Asikainen S, Pussinen PJ. | Infect Immun | 10.1128/iai.71.9.5005-5011.2003 | 2003 | |
| Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity. | DiRienzo JM, McKay TL. | J Clin Microbiol | 10.1128/jcm.32.1.75-81.1994 | 1994 | | |
| Enzymology | Detection and strain identification of Actinobacillus actinomycetemcomitans by nested PCR. | Leys EJ, Griffen AL, Strong SJ, Fuerst PA. | J Clin Microbiol | 10.1128/jcm.32.5.1288-1294.1994 | 1994 | |
| Pathogenicity | Bactericidal activities of synthetic human leukocyte cathepsin G-derived antibiotic peptides and congeners against Actinobacillus actinomycetemcomitans and Capnocytophaga sputigena. | Miyasaki KT, Bodeau AL, Pohl J, Shafer WM. | Antimicrob Agents Chemother | 10.1128/aac.37.12.2710 | 1993 | |
| Phylogeny | Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. | Kaplan JB, Schreiner HC, Furgang D, Fine DH. | J Clin Microbiol | 10.1128/jcm.40.4.1181-1187.2002 | 2002 | |
| Immunochemical and structural characterization of a serotype-specific polysaccharide antigen from Actinobacillus actinomycetemcomitans Y4 (serotype b). | Amano K, Nishihara T, Shibuya N, Noguchi T, Koga T. | Infect Immun | 10.1128/iai.57.10.2942-2946.1989 | 1989 | | |
| Phylogeny | Characterization of serologically nontypeable Actinobacillus actinomycetemcomitans isolates. | Paju S, Saarela M, Alaluusua S, Fives-Taylor P, Asikainen S. | J Clin Microbiol | 10.1128/jcm.36.7.2019-2022.1998 | 1998 | |
| Enzymology | Identification of Actinobacillus actinomycetemcomitans in subgingival plaque by PCR. | Flemmig TF, Rudiger S, Hofmann U, Schmidt H, Plaschke B, Stratz A, Klaiber B, Karch H. | J Clin Microbiol | 10.1128/jcm.33.12.3102-3105.1995 | 1995 | |
| Involvement of SOCS3 in regulation of CD11c+ dendritic cell-derived osteoclastogenesis and severe alveolar bone loss. | Zhang X, Alnaeeli M, Singh B, Teng YT. | Infect Immun | 10.1128/iai.01070-08 | 2009 | | |
| Gamma interferon positively modulates Actinobacillus actinomycetemcomitans-specific RANKL+ CD4+ Th-cell-mediated alveolar bone destruction in vivo. | Teng YT, Mahamed D, Singh B. | Infect Immun | 10.1128/iai.73.6.3453-3461.2005 | 2005 | | |
| Enzymology | Multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. | Tran SD, Rudney JD. | J Clin Microbiol | 10.1128/jcm.34.11.2674-2678.1996 | 1996 | |
| Phylogeny | Evaluation of two commercial kits and arbitrarily primed PCR for identification and differentiation of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, and Haemophilus paraphrophilus. | Dogan B, Asikainen S, Jousimies-Somer H. | J Clin Microbiol | 10.1128/jcm.37.3.742-747.1999 | 1999 | |
| Enzymology | Nuclease-sensitive binding of an Actinobacillus actinomycetemcomitans leukotoxin to the bacterial cell surface. | Ohta H, Kato K, Kokeguchi S, Hara H, Fukui K, Murayama Y. | Infect Immun | 10.1128/iai.59.12.4599-4605.1991 | 1991 | |
| Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. | Brogan JM, Lally ET, Poulsen K, Kilian M, Demuth DR. | Infect Immun | 10.1128/iai.62.2.501-508.1994 | 1994 | | |
| Laser-assisted microbial culturomics. | Qu T, Koch L, Mukherjee R, Tu Y, Seidel AL, Puttmann LD, Winkel A, Yang I, Grischke J, Liu D, Wolkers WF, Kittler S, Chichkov B, Stiesch M, Szafranski SP. | Nat Commun | 10.1038/s41467-025-66804-7 | 2025 | | |
| Rose bengal-mediated photodynamic inactivation against periodontopathogens in vitro. | Wang D, Pan H, Yan Y, Zhang F | Photodiagnosis Photodyn Ther | 10.1016/j.pdpdt.2021.102250 | 2021 | | |
| Antimicrobial activity against periodontopathogenic bacteria, antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica. | Bali EB, Acik L, Akca G, Sarper M, Elci MP, Avcu F, Vural M | Asian Pac J Trop Biomed | 10.12980/APJTB.4.2014APJTB-2013-0010 | 2014 | | |
| Differential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes. | Umeda JE, Longo PL, Simionato MR, Mayer MP | J Oral Microbiol | 10.3402/jom.v5i0.21473 | 2013 | | |
| Pathogenicity | A novel gene required for natural competence in Aggregatibacter actinomycetemcomitans. | Tanaka A, Fujise O, Chen C, Miura M, Hamachi T, Maeda K | J Periodontal Res | 10.1111/j.1600-0765.2011.01410.x | 2011 | |
| Enzymology | Adherence of Aggregatibacter actinomycetemcomitans via serotype-specific polysaccharide antigens in lipopolysaccharides. | Fujise O, Wang Y, Chen W, Chen C | Oral Microbiol Immunol | 10.1111/j.1399-302X.2007.00416.x | 2008 | |
| Pathogenicity | Bone powder enhances the effectiveness of bioactive glass S53P4 against strains of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in suspension. | Waltimo T, Zehnder M, Soderling E | Acta Odontol Scand | 10.1080/00016350500570700 | 2006 | |
| Pathogenicity | The efficacy of povidone-iodine products against periodontopathic bacteria. | Nakagawa T, Hosaka Y, Ishihara K, Hiraishi T, Sato S, Ogawa T, Kamoi K | Dermatology | 10.1159/000089208 | 2006 | |
| Enzymology | Aae, an autotransporter involved in adhesion of Actinobacillus actinomycetemcomitans to epithelial cells. | Rose JE, Meyer DH, Fives-Taylor PM | Infect Immun | 10.1128/IAI.71.5.2384-2393.2003 | 2003 | |
| Pathogenicity | Influence of abiotic factors on the bacteriocinogenic activity of Actinobacillus actinomycetemcomitans. | Lima FL, Farias FF, Carvalho MA, Alviano CS, Farias LM | Res Microbiol | 10.1016/s0923-2508(02)01318-9 | 2002 | |
| Pathogenicity | Bacteriocin production by Actinobacillus actinomycetemcomitans isolated from the oral cavity of humans with periodontal disease, periodontally healthy subjects and marmosets. | Lucia LF, Farias FF, Eustaquio CJ, Auxiliadora M, Carvalho R, Alviano CS, Farias LM | Res Microbiol | 10.1016/s0923-2508(01)01285-2 | 2002 | |
| Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes a, c, d and e. | Perry MB, MacLean LM, Brisson JR, Wilson ME | Eur J Biochem | 10.1111/j.1432-1033.1996.0682r.x | 1996 | | |
| Enzymology | [Identification and typing of Actinobacillus actinomycetemcomitans by restriction endonuclease analysis]. | Han A, Yi X, Xiao X, Zhang J, Tong Y, Xiao Z, Chen J, Li H | Hua Xi Yi Ke Da Xue Xue Bao | 1990 | | |
| Pathogenicity | Effect of eel galectin AJL-1 on periodontopathic bacterial biofilm formation and their lipopolysaccharide-mediated inflammatory cytokine induction. | Takayama S, Saitoh E, Kimizuka R, Yamada S, Kato T | Int J Antimicrob Agents | 10.1016/j.ijantimicag.2009.04.003 | 2009 | |
| Phylogeny | Relationship of Actinobacillus actinomycetemcomitans serotypes to periodontal condition: prevalence and proportions in subgingival plaque. | Yang HW, Huang YF, Chan Y, Chou MY | Eur J Oral Sci | 10.1111/j.1600-0722.2004.00192.x | 2005 | |
| Phylogeny | Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis: frequency in pure cultured isolates. | Yang HW, Asikainen S, Dogan B, Suda R, Lai CH | J Periodontol | 10.1902/jop.2004.75.4.592 | 2004 | |
| Enzymology | Detection of antigenic surface proteins of Actinobacillus actinomycetemcomitans using the immunoblotting method. | Mineyama R | Microbios | 2001 | | |
| Pathogenicity | Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge. | Dongari-Bagtzoglou AI, Ebersole JL | J Periodontal Res | 10.1111/j.1600-0765.1996.tb00469.x | 1996 | |
| Phylogeny | 6-Deoxy-D-talan and 6-deoxy-L-talan. Novel serotype-specific polysaccharide antigens from Actinobacillus actinomycetemcomitans. | Shibuya N, Amano K, Azuma J, Nishihara T, Kitamura Y, Noguchi T, Koga T | J Biol Chem | S0021-9258(18)55299-6 | 1991 | |
| Metabolism | Murine macrophage interleukin-1 release by capsularlike serotype-specific polysaccharide antigens of Actinobacillus actinomycetemcomitans. | Takahashi T, Nishihara T, Ishihara Y, Amano K, Shibuya N, Moro I, Koga T | Infect Immun | 10.1128/iai.59.1.18-23.1991 | 1991 | |
| Pathogenicity | [Chemical analysis and immunochemical characterization of serotype-specific antigens from the strains of Actinobacillus actinomycetemcomitans which were frequently found in the periodontal pockets of the patients of localized juvenile periodontitis]. | Amano K | Aichi Gakuin Daigaku Shigakkai Shi | 1990 | | |
| Phylogeny | Inhibitory effects of rabbit antisera on mitogenic activity of Actinobacillus actinomycetemcomitans lipopolysaccharide. | Nishihara T, Maki E, Ishihara Y, Kato H, Noguchi T, Koga T | J Periodontal Res | 10.1111/j.1600-0765.1989.tb02001.x | 1989 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive137824.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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