Name: Aggregatibacter actinomycetemcomitans Y4
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 11754

Type strain:

Species: Aggregatibacter actinomycetemcomitans

Strain Designation: Y4

Culture col. no.: DSM 11123, ATCC 43718, JCM 8578

Strain history: Tokyo Med. Dent. Univ. <-- ATCC 43718 <-- H. Reynolds Y4 <-- S. S. Socransky.

NCBI tax ID(s): 1035194 (strain), 714 (species)

SI-ID 42003

ATCC 43718, CCUG 37001, DSM 11123, JCM 8578

Other strains from Aggregatibacter actinomycetemcomitans

Section

Aggregatibacter actinomycetemcomitans Y4 is a microaerophile, mesophilic human pathogen that was isolated from subgingival dental plaque.

human pathogen
mesophilic
microaerophile
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Pseudomonadota*
	Class	*Gammaproteobacteria*
	Order	*Pasteurellales*
	Family	*Pasteurellaceae*
	Genus	*Aggregatibacter*
	Species	**Aggregatibacter actinomycetemcomitans**
	Full Scientific Name (LPSN)	Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006

	Synonym	"Bacterium* actinomycetemcomitans"*
	Synonym	Haemophilus actinomycetemcomitans
	Synonym	Actinobacillus actinomycetemcomitans

Information on morphological and physiological properties Morphology

[Ref.: #4215]

Incubation period

1-2 days

Information on culture and growth conditions Culture and growth conditions

[Ref.: #4215]

Culture medium

BHI MEDIUM (DSMZ Medium 215)

[Ref.: #4215]

Culture medium growth

[Ref.: #4215]

Culture medium link

Medium recipe at MediaDive

[Ref.: #4215]

Culture medium composition

expand / minimize

[Ref.: #4215]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #4215]

Culture medium growth

[Ref.: #4215]

Culture medium link

Medium recipe at MediaDive

[Ref.: #4215]

Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #4215]			growth	37 °C
[Ref.: #67770]			growth	37 °C

[Ref.: #4215]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #4215]

Oxygen tolerance

microaerophile

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68377]	D-glucose ChEBI	+	builds acid from	* from API NH
[Ref.: #68377]	ornithine ChEBI	-	degradation	* from API NH
[Ref.: #68377]	tryptophan ChEBI	-	energy source	* from API NH
[Ref.: #68377]	urea ChEBI	-	hydrolysis	* from API NH

	Metabolite production	Metabolite	Production
[Ref.: #68377]		indole ChEBI	no	* from API NH

	Physiological tests	Metabolite	Indole test
[Ref.: #68377]		indole ChEBI	-	* from API NH

	Enzyme	Enzyme activity	EC number
[Ref.: #68377]	beta-galactosidase	-	3.2.1.23	* from API NH
[Ref.: #4215]	catalase	+	1.11.1.6
[Ref.: #4215]	cytochrome-c oxidase	+	1.9.3.1
[Ref.: #68377]	ornithine decarboxylase	-	4.1.1.17	* from API NH
[Ref.: #68377]	tryptophan deaminase	-	4.1.99.1	* from API NH
[Ref.: #68377]	urease	-	3.5.1.5	* from API NH

API® NH:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Penicillinase productionPEN	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from maltoseMAL	Acid from sucroseSAC	Ornithine decarboxylaseODC	Urease/urea hydrolysisURE	LipaseLIP	Alkaline phosphatasePAL	beta-Galactosidasebeta GAL	Proline arylamidaseProA	gamma-Glutamyl transferaseGGT	Indole productionIND
[Ref.: #4215]	6256	-	+	+	+	-	-	-	-	+	-	-	+	-
[Ref.: #4215]	5817	-	+	+	+	+	-	-	-	+	-	-	+	-
[Ref.: #4215]	5818	-	+	+	-	-	-	-	-	+	-	-	+	-
[Ref.: #4215]	5819	-	+	+	-	-	-	-	-	+	-	-	+	-
[Ref.: #4215]	5917	-	+	+	+	+/-	-	-	-	+	-	-	+	-
[Ref.: #4215]	6054	+	+	+	+	-	-	-	+	-	-	+	-	-
[Ref.: #4215]	6055	+	+	+	-	-	-	-	+	-	-	+	-	-
[Ref.: #4215]	6056	+	+	-	-	-	-	-	+	-	-	+	-	-
[Ref.: #4215]	6057	+	+	-	-	-	-	-	+	-	-	+	-	-
[Ref.: #4215]	5816	-	+	+	+	-	-	-	-	+	-	-	+	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #4215]	Sample type/isolated from	subgingival dental plaque
* marker position based on {}

Isolation sources categories

#Host Body-Site	#Oral cavity and airways	#Subgingival plaque
#Host Body-Site	#Oral cavity and airways	#Tooth

What are isolation sources categories?

[Ref.: #69479]

Global distribution of 16S sequence AB595137 (>99% sequence identity) for Aggregatibacter actinomycetemcomitans subclade from Microbeatlas

Aquatic Samples	279
Soil Samples	46
Animal Samples	7969
Plant Samples	42
Total Samples	8336

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #4215]	Pathogenicity (human)	yes
[Ref.: #4215]	Pathogenicity (animal)	yes
[Ref.: #4215]	Biosafety level	2	Risk group (German classification) According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Aggregatibacter actinomycetemcomitans gene for 16S ribosomal RNA, partial sequence, strain: JCM 8578	AB595137	1501	ENA	714 tax ID
[Ref.: #20218]	Actinobacillus actinomycetemcomitans strain ATCC 43718 16S ribosomal RNA gene, partial sequence	AY362884	1362	ENA	1035194 tax ID	*

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Aggregatibacter actinomycetemcomitans Y4	GCA_000318155	scaffold	GenBank	1035194 tax ID	*
[Ref.: #66792]	Aggregatibacter actinomycetemcomitans Y4	1035194.3	wgs	PATRIC	1035194 tax ID	*
[Ref.: #66792]	Aggregatibacter actinomycetemcomitans Y4	2537561947	draft	JGI IMG/M	1035194 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Aggregatibacter actinomycetemcomitans Y4 Y4 NCBI: GCA_000318155.1
[Ref.: #69480]	motile	no	88.927	no
[Ref.: #69480]	flagellated	no	96.933	no
[Ref.: #69480]	gram-positive	no	98.536	no
[Ref.: #69480]	anaerobic	no	93.925	yes
[Ref.: #69480]	aerobic	no	96.166	yes
[Ref.: #69480]	halophile	no	50	no
[Ref.: #69480]	spore-forming	no	98.591	no
[Ref.: #69480]	thermophile	no	96.516	no
[Ref.: #69480]	glucose-util	no	51.447	no
[Ref.: #69480]	glucose-ferment	no	52.109	no

Availability in culture collections External links

[Ref.: #4215]

Culture collection no.

DSM 11123, ATCC 43718, JCM 8578

[Ref.: #80972]

SI-ID 42003

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Synergistic effects of LFchimera and antibiotic against planktonic and biofilm form of Aggregatibacter actinomycetemcomitans.	Lachica MRCT, Anutrakunchai C, Prajaneh S, Nazmi K, Bolscher JGM, Taweechaisupapong S	PLoS One	10.1371/journal.pone.0217205	2019	*
Pathogenicity	Killing activity of LFchimera on periodontopathic bacteria and multispecies oral biofilm formation in vitro.	Ruangcharoen S, Suwannarong W, Lachica MRCT, Bolscher JGM, Nazmi K, Khunkitti W, Taweechaisupapong S	World J Microbiol Biotechnol	10.1007/s11274-017-2334-2	2017	*
Pathogenicity	Antimicrobial effect of lemongrass oil against oral malodour micro-organisms and the pilot study of safety and efficacy of lemongrass mouthrinse on oral malodour.	Satthanakul P, Taweechaisupapong S, Paphangkorakit J, Pesee M, Timabut P, Khunkitti W	J Appl Microbiol	10.1111/jam.12667	2014	*
Pathogenicity	Influence of different biomaterials on the viability of Aggregatibacter actinomycetemcomitans.	Kasaj A, Willershausen B, Junker R, Callaway A, Krahn U, Kraft B, Pietsch M	Arch Oral Biol	10.1016/j.archoralbio.2011.02.013	2011	*
Metabolism	Differential epithelial cell response upon stimulation with the Aggregatibacter actinomycetemcomitans strains VT 1169, VT 1560 DAM(-) and ATCC 4318.	Eberhard J, Banasch T, Jepsen S, Dommisch H	Epigenetics	10.4161/epi.5.8.13106	2010	*
Pathogenicity	Reduction of periodontal pathogens adhesion by antagonistic strains.	Van Hoogmoed CG, Geertsema-Doornbusch GI, Teughels W, Quirynen M, Busscher HJ, Van der Mei HC	Oral Microbiol Immunol	10.1111/j.1399-302X.2007.00388.x	2008	*
Pathogenicity	Effect of ciprofloxacin on killing of Actinobacillus actinomycetemcomitans by polymorphonuclear leukocytes.	Cacchillo DA, Walters JD	Antimicrob Agents Chemother	10.1128/AAC.46.6.1980-1984.2002	2002	*
Pathogenicity	Influence of surface modifications to titanium on antibacterial activity in vitro.	Yoshinari M, Oda Y, Kato T, Okuda K	Biomaterials	10.1016/s0142-9612(00)00392-6	2001	*
Pathogenicity	Influence of surface modifications to titanium on oral bacterial adhesion in vitro.	Yoshinari M, Oda Y, Kato T, Okuda K, Hirayama A	J Biomed Mater Res	10.1002/1097-4636(200011)52:2<388::aid-jbm20>3.0.co;2-e	2000	*
Pathogenicity	Novel apoptosis-inducing activity in Bacteroides forsythus: a comparative study with three serotypes of Actinobacillus actinomycetemcomitans.	Arakawa S, Nakajima T, Ishikura H, Ichinose S, Ishikawa I, Tsuchida N	Infect Immun	10.1128/IAI.68.8.4611-4615.2000	2000	*
Phylogeny	Heterogeneity in the immune response to serotype b LPS of Actinobacillus actinomycetemcomitans in inbred strains of mice.	Kato T, Honma K, Yamanaka A, Miura T, Okuda K	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.2000.tb01458.x	2000	*
Pathogenicity	Antigenic components of Actinobacillus actinomycetemcomitans lipopolysaccharide recognized by sera from patients with localized juvenile periodontitis.	Gu K, Bainbridge B, Darveau RP, Page RC	Oral Microbiol Immunol	10.1111/j.1399-302x.1998.tb00726.x	1998	*
Enzymology	Isolation and characterization of hemolytic genes from Actinobacillus actinomycetemcomitans.	Kato T, Kimizuka R, Okuda K	FEMS Microbiol Lett	10.1111/j.1574-6968.1996.tb08483.x	1996	*
Metabolism	Identification of an immunoglobulin Fc receptor of Actinobacillus actinomycetemcomitans.	Mintz KP, Fives-Taylor PM	Infect Immun	10.1128/iai.62.10.4500-4505.1994	1994	*
Enzymology	Identification and analysis of the gap region in the 23S ribosomal RNA from Actinobacillus actinomycetemcomitans.	Haraszthy VI, Sunday GJ, Bobek LA, Motley TS, Preus H, Zambon JJ	J Dent Res	10.1177/00220345920710090401	1992	*
Pathogenicity	Evidence that the serotype b antigenic determinant of Actinobacillus actinomycetemcomitans Y4 resides in the polysaccharide moiety of lipopolysaccharide.	Wilson ME, Schifferle RE	Infect Immun	10.1128/iai.59.4.1544-1551.1991	1991	*
Metabolism	Differential effects of five Aggregatibacter actinomycetemcomitans strains on gingival epithelial cells.	Shimada T, Sugano N, Nishihara R, Suzuki K, Tanaka H, Ito K	Oral Microbiol Immunol	10.1111/j.1399-302X.2008.00449.x	2008	*
Phylogeny	Bacterial adhesion of Actinobacillus actinomycetemcomitans serotypes to titanium implants: SEM evaluation. A preliminary report.	Okte E, Sultan N, Dogan B, Asikainen S	J Periodontol	10.1902/jop.1999.70.11.1376	1999	*
Enzymology	Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein.	Komatsuzawa H, Kawai T, Wilson ME, Taubman MA, Sugai M, Suginaka H	Infect Immun	10.1128/IAI.67.2.942-945.1999	1999	*
	A simple viability-maintaining method produces homogenic cell suspensions of autoaggregating wild-type Actinobacillus actinomycetemcomitans.	Karched M, Paul-Satyaseela M, Asikainen S	J Microbiol Methods	10.1016/j.mimet.2006.06.004	2006	*

References

#4215

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 11123

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#68377

Automatically annotated from API NH .

#69479

João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#80972

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID42003.1 )

* These data were automatically processed and therefore are not curated

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Aggregatibacter actinomycetemcomitans Y4 Y4

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