Mycobacterium smegmatis DSM 43464 is a human pathogen that was isolated from phage host.
human pathogen Bacteria
SI-ID 38862
| @ref 20215 |
Last LPSN update
2026-02-09 11:19:40 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Mycobacteriales |
| Family Mycobacteriaceae |
| Genus Mycobacterium |
| Species Mycobacterium smegmatis |
| Full scientific name Mycobacterium smegmatis (Trevisan 1889) Lehmann and Neumann 1899 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 11039 | MIDDLEBROOK MEDIUM (DSMZ Medium 645) | Medium recipe at MediaDive  | Name: MIDDLEBROOK MEDIUM (DSMZ Medium 645) Composition: Bacto Middlebrook 7H10 agar 20.9945 g/l Glycerol Distilled water | ||
| 11039 | LÖWENSTEIN-JENSEN MEDIUM (DSMZ Medium 354) | Medium recipe at MediaDive | Name: LÖWENSTEIN-JENSEN MEDIUM (DSMZ Medium 354) Composition: Potato flour 18.6104 g/l L-Asparagin 2.23325 g/l KH2PO4 1.55087 g/l Mg-citrate 0.372208 g/l Malachite green 0.248139 g/l MgSO4 0.148883 g/l Glycerol Fresh egg mixture Distilled water |
| @ref | Growth | Type | Temperature (°C) | |
|---|---|---|---|---|
| 11039 | positive | growth | 37 |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Use of the hupB gene encoding a histone-like protein of Mycobacterium tuberculosis as a target for detection and differentiation of M. tuberculosis and M. bovis. | Prabhakar S, Mishra A, Singhal A, Katoch VM, Thakral SS, Tyagi JS, Prasad HK. | J Clin Microbiol | 10.1128/jcm.42.6.2724-2732.2004 | 2004 |  | |
| A novel transposon trap for mycobacteria: isolation and characterization of IS1096. | Cirillo JD, Barletta RG, Bloom BR, Jacobs WR. | J Bacteriol | 10.1128/jb.173.24.7772-7780.1991 | 1991 | | |
| Is dUTPase Enzymatic Activity Truly Essential for Viability? | Glukhov A, Dzhus U, Kolyadenko I, Selikhanov G, Gabdulkhakov A. | Int J Mol Sci | 10.3390/ijms26199260 | 2025 | | |
| Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. | Cao M, Yang D, Adhikari A, Ye F, Zheng C, Yan W, Meng S, Su P, Shen B. | Org Lett | 10.1021/acs.orglett.2c04303 | 2023 | | |
| Acylation of glycerolipids in mycobacteria. | Angala SK, Carreras-Gonzalez A, Huc-Claustre E, Anso I, Kaur D, Jones V, Palcekova Z, Belardinelli JM, de Sousa-d'Auria C, Shi L, Slama N, Houssin C, Quemard A, McNeil M, Guerin ME, Jackson M. | Nat Commun | 10.1038/s41467-023-42478-x | 2023 | | |
| Dissecting the Mechanism of Intracellular Mycobacterium smegmatis Growth Inhibition by Platelet Activating Factor C-16. | Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. | Front Microbiol | 10.3389/fmicb.2020.01046 | 2020 | | |
| Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids. | Jurkowitz MS, Azad AK, Monsma PC, Keiser TL, Kanyo J, Lam TT, Bell CE, Schlesinger LS. | J Biol Chem | 10.1016/j.jbc.2022.101849 | 2022 | | |
| Phospholipase C: underrated players in microbial infections. | Singh V, Rai R, Mathew BJ, Chourasia R, Singh AK, Kumar A, Chaurasiya SK. | Front Cell Infect Microbiol | 10.3389/fcimb.2023.1089374 | 2023 | | |
| alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi. | Burugupalli S, Almeida CF, Smith DGM, Shah S, Patel O, Rossjohn J, Uldrich AP, Godfrey DI, Williams SJ. | Chem Sci | 10.1039/c9sc05248h | 2020 | | |
| Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization. | Prithviraj M, Kado T, Mayfield JA, Young DC, Huang AD, Motooka D, Nakamura S, Siegrist MS, Moody DB, Morita YS. | mBio | 10.1128/mbio.03396-22 | 2023 | | |
| Synthesis, structural elucidation, and biochemical analysis of immunoactive glucuronosyl diacylglycerides of mycobacteria and corynebacteria. | Cao B, Chen X, Yamaryo-Botte Y, Richardson MB, Martin KL, Khairallah GN, Rupasinghe TW, O'Flaherty RM, O'Hair RA, Ralton JE, Crellin PK, Coppel RL, McConville MJ, Williams SJ. | J Org Chem | 10.1021/jo302508e | 2013 | | |
| Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A. | Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM. | Nat Commun | 10.1038/s41467-025-58133-6 | 2025 | | |
| Pathogenicity | Therapeutic Bioactivity Exerted by the Apis mellifera Bee Venom and Its Major Protein Melittin: A Scoping Review. | Erdogan PM, Bilgili-Tetikoglu F, Celik-Uzuner S, Yildiz O, Kolayli S, Mossialos D. | Molecules | 10.3390/molecules30194003 | 2025 | |
| Enzymology | Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase. | Goins CM, Schreidah CM, Dajnowicz S, Ronning DR. | J Biol Chem | 10.1074/jbc.ra117.000240 | 2018 | |
| Characterization of mycobacterial triacylglycerols and monomeromycolyl diacylglycerols from Mycobacterium smegmatis biofilm by electrospray ionization multiple-stage and high-resolution mass spectrometry. | Purdy GE, Pacheco S, Turk J, Hsu FF. | Anal Bioanal Chem | 10.1007/s00216-013-7179-4 | 2013 | | |
| Sequencing and Optical Genome Mapping for the Adventurous Chemist. | Ruppeka Rupeika E, D'Huys L, Leen V, Hofkens J. | Chem Biomed Imaging | 10.1021/cbmi.4c00060 | 2024 | | |
| Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. | Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. | Front Microbiol | 10.3389/fmicb.2018.01903 | 2018 | | |
| Metabolism | Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope. | Powers MJ, Trent MS. | Proc Natl Acad Sci U S A | 10.1073/pnas.1902026116 | 2019 | |
| Health Benefits of Consuming Foods with Bacterial Probiotics, Postbiotics, and Their Metabolites: A Review. | Vera-Santander VE, Hernandez-Figueroa RH, Jimenez-Munguia MT, Mani-Lopez E, Lopez-Malo A. | Molecules | 10.3390/molecules28031230 | 2023 | | |
| slr2103, a homolog of type-2 diacylglycerol acyltransferase genes, for plastoquinone-related neutral lipid synthesis and NaCl-stress acclimatization in a cyanobacterium, Synechocystis sp. PCC 6803. | Kondo M, Aoki M, Hirai K, Sagami T, Ito R, Tsuzuki M, Sato N. | Front Plant Sci | 10.3389/fpls.2023.1181180 | 2023 | | |
| Rv3091, An Extracellular Patatin-Like Phospholipase in Mycobacterium tuberculosis, Prolongs Intracellular Survival of Recombinant Mycolicibacterium smegmatis by Mediating Phagosomal Escape. | Cui Z, Dang G, Song N, Cui Y, Li Z, Zang X, Liu H, Wang Z, Liu S. | Front Microbiol | 10.3389/fmicb.2020.532371 | 2020 | | |
| Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery. | Porras G, Chassagne F, Lyles JT, Marquez L, Dettweiler M, Salam AM, Samarakoon T, Shabih S, Farrokhi DR, Quave CL. | Chem Rev | 10.1021/acs.chemrev.0c00922 | 2021 | | |
| Post-translational Lysine Ac(et)ylation in Bacteria: A Biochemical, Structural, and Synthetic Biological Perspective. | Lammers M. | Front Microbiol | 10.3389/fmicb.2021.757179 | 2021 | | |
| Metabolism | Synthesis of azide derivative and discovery of glyoxalase pathway inhibitor against pathogenic bacteria. | Edagwa B, Wang Y, Narayanasamy P. | Bioorg Med Chem Lett | 10.1016/j.bmcl.2013.09.011 | 2013 | |
| Metabolism | Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis. | Nigou J, Besra GS. | Biochem J | 10.1042/bj20020370 | 2002 | |
| Pathogenicity | Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine. | Sparr C, Purkayastha N, Kolesinska B, Gengenbacher M, Amulic B, Matuschewski K, Seebach D, Kamena F. | Antimicrob Agents Chemother | 10.1128/aac.00427-13 | 2013 | |
| Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. | Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M. | Proc Natl Acad Sci U S A | 10.1073/pnas.1220601110 | 2013 | | |
| Metabolism | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. | Kottur J, Nair DT. | Nucleic Acids Res | 10.1093/nar/gky402 | 2018 | |
| MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns. | Richardson MB, Williams SJ. | Front Immunol | 10.3389/fimmu.2014.00288 | 2014 | | |
| Enzymology | Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase. | Hillmann F, Argentini M, Buddelmeijer N. | J Biol Chem | 10.1074/jbc.m111.243519 | 2011 | |
| Biosynthesis of Galactan in Mycobacterium tuberculosis as a Viable TB Drug Target? | Konyarikova Z, Savkova K, Kozmon S, Mikusova K. | Antibiotics (Basel) | 10.3390/antibiotics9010020 | 2020 | | |
| N5 Is the New C4a: Biochemical Functionalization of Reduced Flavins at the N5 Position. | Beaupre BA, Moran GR. | Front Mol Biosci | 10.3389/fmolb.2020.598912 | 2020 | | |
| Synthesis of Naphthoquinone Derivatives: Menaquinones, Lipoquinones and Other Vitamin K Derivatives. | Braasch-Turi M, Crans DC. | Molecules | 10.3390/molecules25194477 | 2020 | | |
| Metabolism | How lipid droplets "TAG" along: Glycerolipid synthetic enzymes and lipid storage. | Wang H, Airola MV, Reue K. | Biochim Biophys Acta Mol Cell Biol Lipids | 10.1016/j.bbalip.2017.06.010 | 2017 | |
| Pathogenicity | The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. | Macho-Fernandez E, Brigl M. | Front Immunol | 10.3389/fimmu.2015.00362 | 2015 | |
| Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis. | Holzheimer M, Buter J, Minnaard AJ. | Chem Rev | 10.1021/acs.chemrev.1c00043 | 2021 | | |
| Enzymology | Bacilysocin, a novel phospholipid antibiotic produced by Bacillus subtilis 168. | Tamehiro N, Okamoto-Hosoya Y, Okamoto S, Ubukata M, Hamada M, Naganawa H, Ochi K. | Antimicrob Agents Chemother | 10.1128/aac.46.2.315-320.2002 | 2002 | |
| Metabolism | Purification and characterization of mycobacterial phospholipase A: an activity associated with mycobacterial cutinase. | Parker SK, Curtin KM, Vasil ML. | J Bacteriol | 10.1128/jb.01909-06 | 2007 | |
| Metabolism | Chlorinated fatty acid distribution in Mycobacterium convolutum phospholipids after growth on 1-chlorohexadecane. | Murphy GL, Perry JJ. | Appl Environ Microbiol | 10.1128/aem.53.1.10-13.1987 | 1987 | |
| Biomarker discovery for tuberculosis using metabolomics. | Yu Y, Jiang XX, Li JC. | Front Mol Biosci | 10.3389/fmolb.2023.1099654 | 2023 | | |
| Structure-function relationships of membrane-associated GT-B glycosyltransferases. | Albesa-Jove D, Giganti D, Jackson M, Alzari PM, Guerin ME. | Glycobiology | 10.1093/glycob/cwt101 | 2014 | | |
| Metabolism | Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase. | Sahonero-Canavesi DX, Sohlenkamp C, Sandoval-Calderon M, Lamsa A, Pogliano K, Lopez-Lara IM, Geiger O. | Environ Microbiol | 10.1111/1462-2920.12814 | 2015 | |
| Metabolism | Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin. | Parker SK, Barkley RM, Rino JG, Vasil ML. | PLoS One | 10.1371/journal.pone.0004281 | 2009 | |
| Metabolism | Leukocyte lipid bodies - Biogenesis and functions in inflammation. | Bozza PT, Magalhaes KG, Weller PF. | Biochim Biophys Acta | 10.1016/j.bbalip.2009.01.005 | 2009 | |
| Enzymology | Substrate-bound crystal structures reveal features unique to Mycobacterium tuberculosis N-acetyl-glucosamine 1-phosphate uridyltransferase and a catalytic mechanism for acetyl transfer. | Jagtap PK, Soni V, Vithani N, Jhingan GD, Bais VS, Nandicoori VK, Prakash B. | J Biol Chem | 10.1074/jbc.m112.390765 | 2012 | |
| Chemical Reporters for Bacterial Glycans: Development and Applications. | Banahene N, Kavunja HW, Swarts BM. | Chem Rev | 10.1021/acs.chemrev.1c00729 | 2022 | | |
| Metabolism | Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis. | Mahanta N, Hudson GA, Mitchell DA. | Biochemistry | 10.1021/acs.biochem.7b00771 | 2017 | |
| Metabolism | Noncanonical reactions of flavoenzymes. | Sobrado P. | Int J Mol Sci | 10.3390/ijms131114219 | 2012 | |
| Enzymology | Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis. | Schiebel J, Kapilashrami K, Fekete A, Bommineni GR, Schaefer CM, Mueller MJ, Tonge PJ, Kisker C. | J Biol Chem | 10.1074/jbc.m113.511436 | 2013 | |
| Metabolism | Bacterial Sphingomyelinases and Phospholipases as Virulence Factors. | Flores-Diaz M, Monturiol-Gross L, Naylor C, Alape-Giron A, Flieger A. | Microbiol Mol Biol Rev | 10.1128/mmbr.00082-15 | 2016 | |
| Arbutus unedo L.: chemical and biological properties. | Miguel MG, Faleiro ML, Guerreiro AC, Antunes MD. | Molecules | 10.3390/molecules191015799 | 2014 | | |
| Enzymology | A study of archaeal enzymes involved in polar lipid synthesis linking amino acid sequence information, genomic contexts and lipid composition. | Daiyasu H, Kuma K, Yokoi T, Morii H, Koga Y, Toh H. | Archaea | 10.1155/2005/452563 | 2005 | |
| Genetics | DNA repair and genome maintenance in Bacillus subtilis. | Lenhart JS, Schroeder JW, Walsh BW, Simmons LA. | Microbiol Mol Biol Rev | 10.1128/mmbr.05020-11 | 2012 | |
| Metabolism | Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis. | Waldman AJ, Ng TL, Wang P, Balskus EP. | Chem Rev | 10.1021/acs.chemrev.6b00621 | 2017 | |
| Metabolism | The sweet tooth of bacteria: common themes in bacterial glycoconjugates. | Tytgat HL, Lebeer S. | Microbiol Mol Biol Rev | 10.1128/mmbr.00007-14 | 2014 | |
| Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. | Kharel MK, Pahari P, Shepherd MD, Tibrewal N, Nybo SE, Shaaban KA, Rohr J. | Nat Prod Rep | 10.1039/c1np00068c | 2012 | | |
| Metabolism | Radical S-adenosylmethionine enzymes. | Broderick JB, Duffus BR, Duschene KS, Shepard EM. | Chem Rev | 10.1021/cr4004709 | 2014 | |
| The mononuclear molybdenum enzymes. | Hille R, Hall J, Basu P. | Chem Rev | 10.1021/cr400443z | 2014 | | |
| Pathogenicity | Acanthamoeba polyphaga-enhanced growth of Mycobacterium smegmatis. | Lamrabet O, Mba Medie F, Drancourt M | PLoS One | 10.1371/journal.pone.0029833 | 2012 | |
| Metabolism | Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2. | Anilkumar G, Srinivasan R, Ajitkumar P | Microbiology (Reading) | 10.1099/mic.0.27090-0 | 2004 | |
| Enzymology | Characterization of a beta-lactamase from Mycobacterium smegmatis SN2. | Basu D, Narayankumar DV, Van Beeumen J, Basu J | Biochem Mol Biol Int | 10.1080/15216549700204361 | 1997 | |
| Metabolism | Ribosomal RNA methylation in Mycobacterium smegmatis SN2. | Srivastava R, Gopinathan KP | Biochem Int | 1987 | | |
| Enzymology | Arginyl-tRNA synthetase from Mycobacterium smegmatis SN2: purification and kinetic mechanism. | Char S, Gopinathan KP | J Biochem | 10.1093/oxfordjournals.jbchem.a121721 | 1986 | |
| Enzymology | Purification and kinetic mechanism of lysyl-tRNA synthetase from Mycobacterium smegmatis SN2. | Char S, Gopinathan KP | Biochem Int | 1985 | | |
| Pathogenicity | Transfection of Mycobacterium smegmatis SN2 with mycobacteriophage I3 DNA. | Karnik SS, Gopinathan KP | Arch Microbiol | 10.1007/BF00425216 | 1983 | |
| Metabolism | [Presence of histidine-degrading enzymes in mycobacteria and nocardia and reaction-kinetic studies on Mycobacterium smegmatis SN 2 (author's transl)]. | Rohrscheidt E | Zentralbl Bakteriol A | 1980 | | |
| Phylogeny | Interfamilial transfer of amber suppressor gene for the isolation of amber mutants of Mycobacteriophage I3. | Ramakrishnan T, Shaila MS | Arch Microbiol | 10.1007/BF00423080 | 1979 | |
| Pathogenicity | Transduction of isoniazid susceptibility-resistance and streptomycin resistance in mycobacteria. | Saroja D, Gopinathan KP | Antimicrob Agents Chemother | 10.1128/AAC.4.6.643 | 1973 | |
| Structure of a transducing mycobacteriophage. | Kozloff LM, Sundar Raj CV, Rao RN, Chapman VA, DeLong S | J Virol | 10.1128/JVI.9.2.390-393.1972 | 1972 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive8318.20251217.10
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BacDive in 2025: the core database for prokaryotic strain data
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