Lactobacillus acidophilus (DSM 20242, JCM 2124)

Name: Lactobacillus acidophilus (DSM 20242, JCM 2124)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6405

Type strain

Culture col. no. DSM 20242 JCM 2124

NCBI tax ID(s) 1226679 1579

Special Collections DSMZ JCM

Links

Lactobacillus acidophilus DSM 20242 is an anaerobe, mesophilic prokaryote that produces lactate and was isolated from Vagina.

lactate production anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 92212

LMG 11430,ATCC 4357,DSM 20242,JCM 5342,LMG 13003,NCFB 1697,NCIMB 8607,NCIB 8607,CIP 103595,NCDO 1697,KCTC 3171,LMD 47.25,NCCB 47025,BCRC 17008,CCRC 17008

@ref 20215

Last LPSN update 2025-12-16 09:48:19

Domain Bacillati

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lactobacillus

Species Lactobacillus acidophilus

Full scientific name Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970 (Approved Lists 1980)

Synonyms (1)

"Bacillus acidophilus"

BacDive ID	Other strains from **Lactobacillus acidophilus** (35)	Type strain
6404	L. acidophilus L917, Scav, DSM 20079, ATCC 4356, NCDO 1748, ... (type strain)
6403	L. acidophilus A 16, DSM 9126, ATCC 13651, NCDO 1360
135119	L. acidophilus CIP 104455
135293	L. acidophilus R-1-1, CIP 103596, ATCC 4355, JCM 1021, KCTC ...
135306	L. acidophilus 4B, CIP 103597, ATCC 832, NCDO 1, NCTC 1723, ...
135307	L. acidophilus 43, CIP 103598, ATCC 314, JCM 2121
136312	L. acidophilus CIP 104457, ATCC 11975, NCDO 2, NCTC 1899, ...
137096	L. acidophilus CIP 103600, VPI 11473
137247	L. acidophilus A18, CIP 103601
137642	L. acidophilus Pak, CIP 103595, ATCC 4357, NCDO 1697, NCIMB ...
137667	L. acidophilus 65 AC, CIP 104463
137731	L. acidophilus 184.85, CIP 101490
137879	L. acidophilus 174-86, CIP 102104
137884	L. acidophilus 219-86, CIP 102108
138689	L. acidophilus CIP 102079
141878	L. acidophilus CCUG 8032
142532	L. acidophilus CCUG 12853, LMG 8151
145069	L. acidophilus CCUG 27599
145073	L. acidophilus CCUG 27603
145405	L. acidophilus CCUG 28373
145772	L. acidophilus CCUG 29549 B
146144	L. acidophilus CCUG 30451
146219	L. acidophilus CCUG 30632
147334	L. acidophilus CCUG 33386 A
147807	L. acidophilus CCUG 34264
149472	L. acidophilus CCUG 37804
160902	L. acidophilus JCM 1028, KCTC 3145, LMG 18178
160907	L. acidophilus JCM 1033, KCTC 3150
160908	L. acidophilus JCM 1034, KCTC 3151
160915	L. acidophilus JCM 1035, KCTC 3152
161124	L. acidophilus JCM 11047
161209	L. acidophilus JCM 1229, KCTC 3168
165573	L. acidophilus JCM 7711
170959	L. acidophilus 61N, CRBIP24.117
170960	L. acidophilus A31, CRBIP24.142

Morphology

Cell morphology

@ref	Confidence	Gram stain
125438	93
125438	92.59	positive
125439	98.2	positive

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
8653	MRS MEDIUM (DSMZ Medium 11)		Medium recipe at MediaDive	Name: MRS MEDIUM (DSMZ Medium 11) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Distilled water
35006	MEDIUM 40- for Lactobacillus and Leuconostoc			Distilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g)

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
8653	positive	growth	37	mesophilic
35006	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
8653	anaerobe
8653	microaerophile
125439	microaerophile	96.4

Spore formation

@ref	Spore formation	Confidence
125438		90.855

Compound production

8653

CompoundDL lactic acid

Murein

@ref	Murein short key	Type
8653	A11.31	A4alpha L-Lys-D-Asp

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	+	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
8653	-	-	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+	-	-	+	+	-	+	+	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
8653	-	-	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+	+	-	+	+	+	+	+	-	+	+	-	-	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-
8653	-	-	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+	+	-	+	+	-	+	+	-	+	+	-	-	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation

67770

Sample typeVagina

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Biosafety level	Biosafety level comment
8653	yes, in single cases	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	LaDSM20242V1 assembly for Lactobacillus acidophilus DSM 20242	contig	GCA_000442825	1226679.3	2602041538	1226679	74.37

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Lactobacillus acidophilus gene for 16S rRNA, partial sequence, strain: JCM 2124.	AB289019	676		1579

GC content

@ref	GC-content (mol%)
8653	36.7
67770	35

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Lactobacillus acidophilus DSM 20242
NCBI: GCA_000442825

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	96.40	no
125439	gram_stain	BacteriaNetⓘ	positive	98.20	no
125439	motility	BacteriaNetⓘ	no	87.00	no
125439	spore_formation	BacteriaNetⓘ	no	83.90	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Lactobacillus acidophilus DSM 20242
PATRIC: 1226679.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	92.59	no
125438	anaerobic	anaerobicⓘ	no	71.83	no
125438	spore-forming	spore-formingⓘ	no	90.86	no
125438	aerobic	aerobicⓘ	no	95.55	no
125438	thermophilic	thermophileⓘ	no	97.50	no
125438	flagellated	motile2+ⓘ	no	93.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	In silico prospection of Lactobacillus acidophilus strains with potential probiotic activity.	Dias RS, Kremer FS, da Costa de Avila LF.	Braz J Microbiol	10.1007/s42770-023-01139-3	2023
Genetics	Comparative Genomics and Specific Functional Characteristics Analysis of Lactobacillus acidophilus.	Huang Z, Zhou X, Stanton C, Ross RP, Zhao J, Zhang H, Yang B, Chen W.	Microorganisms	10.3390/microorganisms9091992	2021
Genetics	Development of a High-Resolution Single-Nucleotide Polymorphism Strain-Typing Assay Using Whole Genome-Based Analyses for the Lactobacillus acidophilus Probiotic Strain.	Huang CH, Chen CC, Chiu SH, Liou JS, Lin YC, Lin JS, Huang L, Watanabe K.	Microorganisms	10.3390/microorganisms8091445	2020
	Draft Genome Sequences of Five Strains of Lactobacillus acidophilus, Strain CIP 76.13T, Isolated from Humans, Strains CIRM-BIA 442 and CIRM-BIA 445, Isolated from Dairy Products, and Strains DSM 20242 and DSM 9126 of Unknown Origin.	Falentin H, Cousin S, Clermont D, Creno S, Ma L, Chuat V, Loux V, Rudiger P, Bizet C, Bouchier C.	Genome Announc	10.1128/genomea.00658-13	2013
Metabolism	An Extracellular Cell-Attached Pullulanase Confers Branched alpha-Glucan Utilization in Human Gut Lactobacillus acidophilus.	Moller MS, Goh YJ, Rasmussen KB, Cypryk W, Celebioglu HU, Klaenhammer TR, Svensson B, Abou Hachem M.	Appl Environ Microbiol	10.1128/aem.00402-17	2017
Enzymology	The domestication of the probiotic bacterium Lactobacillus acidophilus.	Bull MJ, Jolley KA, Bray JE, Aerts M, Vandamme P, Maiden MC, Marchesi JR, Mahenthiralingam E.	Sci Rep	10.1038/srep07202	2014
	Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review.	Jensen AP, Bjornvad CR.	J Vet Intern Med	10.1111/jvim.15554	2019
	Open-label trial of a multi-strain synbiotic in cats with chronic diarrhea.	Hart ML, Suchodolski JS, Steiner JM, Webb CB.	J Feline Med Surg	10.1177/1098612x11434386	2012
Phylogeny	Rapid species-level identification of vaginal and oral lactobacilli using MALDI-TOF MS analysis and 16S rDNA sequencing.	Anderson AC, Sanunu M, Schneider C, Clad A, Karygianni L, Hellwig E, Al-Ahmad A.	BMC Microbiol	10.1186/s12866-014-0312-5	2014
Phylogeny	PCR for detection and identification of Abiotrophia spp.	Roggenkamp A, Leitritz L, Baus K, Falsen E, Heesemann J.	J Clin Microbiol	10.1128/jcm.36.10.2844-2846.1998	1998
Metabolism	Production of multiple bacteriocins, including the novel bacteriocin gassericin M, by Lactobacillus gasseri LM19, a strain isolated from human milk.	Garcia-Gutierrez E, O'Connor PM, Colquhoun IJ, Vior NM, Rodriguez JM, Mayer MJ, Cotter PD, Narbad A.	Appl Microbiol Biotechnol	10.1007/s00253-020-10493-3	2020
Metabolism	The antioxidant and prebiotic properties of lactobionic acid.	Goderska K	Appl Microbiol Biotechnol	10.1007/s00253-019-09754-7	2019
Enzymology	Hypolipidemic effects of lactic acid bacteria fermented cereal in rats.	Banjoko IO, Adeyanju MM, Ademuyiwa O, Adebawo OO, Olalere RA, Kolawole MO, Adegbola IA, Adesanmi TA, Oladunjoye TO, Ogunnowo AA, Shorinola AA, Daropale O, Babatope EB, Osibogun AO, Ogunfowokan DT, Jentegbe TA, Apelehin TG, Ogunnowo O, Olokodana O, Fetuga FY, Omitola M, Okafor LA, Ebohon CL, Ita JO, Disu KA, Ogherebe O, Eriobu SU, Bakare AA	Lipids Health Dis	10.1186/1476-511X-11-170	2012
Phylogeny	Isolation and partial characterization of bacteriocins produced by Lactobacillus gasseri JCM 2124.	Tahara T, Yoshioka S, Utsumi R, Kanatani K	FEMS Microbiol Lett	10.1111/j.1574-6968.1997.tb10273.x	1997

References

#8653	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20242
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#35006	; Curators of the CIP;
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lactobacillus acidophilus (DSM 20242, JCM 2124)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Murein

Metabolite utilization

API 50CHac

Isolation, sampling and environmental information

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000442825

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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