Lactobacillus acidophilus Pak is a facultative anaerobe, Gram-positive, rod-shaped bacterium that was isolated from Human.
Gram-positive rod-shaped facultative anaerobe 16S sequence Bacteria| @ref 20215 |
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| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Lactobacillales |
| Family Lactobacillaceae |
| Genus Lactobacillus |
| Species Lactobacillus acidophilus |
| Full scientific name Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970 (Approved Lists 1980) |
| Synonyms (1) |
| @ref | Gram stain | Cell shape | Motility | |
|---|---|---|---|---|
| 38457 | positive | rod-shaped |
| @ref | Name | Growth | Composition | Medium link | |
|---|---|---|---|---|---|
| 38457 | MEDIUM 40- for Lactobacillus and Leuconostoc | Distilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g) | |||
| 38457 | CIP Medium 40 | Medium recipe at CIP |
| 38457 | Oxygen tolerancefacultative anaerobe |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 27613 ChEBI | amygdalin | - | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | - | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | + | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | - | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 50CH acid |
| 68371 | 16024 ChEBI | D-mannose | + | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | - | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 68371 | 4853 ChEBI | esculin | + | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | - | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | - | builds acid from | from API 50CH acid |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17716 ChEBI | lactose | - | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | - | builds acid from | from API 50CH acid |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 28053 ChEBI | melibiose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | - | builds acid from | from API 50CH acid |
| 38457 | 17632 ChEBI | nitrate | - | reduction | |
| 38457 | 17632 ChEBI | nitrate | + | respiration | |
| 38457 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | Potassium 5-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | 16634 ChEBI | raffinose | - | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | - | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | - | builds acid from | from API 50CH acid |
| 68371 | 17992 ChEBI | sucrose | + | builds acid from | from API 50CH acid |
| 68371 | 27082 ChEBI | trehalose | - | builds acid from | from API 50CH acid |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 38457 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | + | 3.2.1.23 | from API zym |
| 68382 | beta-glucosidase | + | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 38457 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 38457 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 38457 | ornithine decarboxylase | - | 4.1.1.17 | |
| 38457 | oxidase | - | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 38457 | not determinedn.d. | - | - | - | - | - | - | - | - | - | - | + | + | + | - | - | - | - | - | - | - | - | - | - | - | + | - | - | - | - | - | + | - | - | - | - | - | - | - | - | +/- | - | - | - | - | - | - | - | - | - |
| @ref | Sample type | Country | Country ISO 3 Code | Continent | |
|---|---|---|---|---|---|
| 38457 | Human | United States of America | USA | North America |
| @ref | Biosafety level | Biosafety level comment | |
|---|---|---|---|
| 38457 | 1 | Risk group (French classification) |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Review on the Function, Substrate Affinity, and Potential Application of Bile Salt Hydrolase Originated from Probiotic Strains of Lactobacillus, Bifidobacterium, and Enterococcus. | Kang MH, Elnar AG, Kim GB. | Food Sci Anim Resour | 10.5851/kosfa.2025.e1 | 2025 | ||
| Inhibition of protein kinase C-alpha and activation of ezrin by Lactobacillus acidophilus restore Na+/H+ exchange activity and fluid absorption in db/db mice. | Han Y, Srinivasan S, Yun CC. | Am J Physiol Endocrinol Metab | 10.1152/ajpendo.00145.2023 | 2023 | ||
| Comparative Evaluation of Antimicrobial Activity and Minimum Inhibitory Concentration of Commercially Available Pediatric Dentifrices: An In Vitro Study. | Dureha R, Navit S, Khan SA, Mathur P. | Int J Clin Pediatr Dent | 10.5005/jp-journals-10005-2939 | 2024 | ||
| Metabolism | Analysis of gut microbiota-derived metabolites regulating pituitary neuroendocrine tumors through network pharmacology. | Cao M, Huang P, Xu LS, Zhang YH. | Front Pharmacol | 10.3389/fphar.2024.1403864 | 2024 | |
| Identification of Gut Microbiome Metabolites via Network Pharmacology Analysis in Treating Alcoholic Liver Disease. | Oh KK, Choi YR, Gupta H, Ganesan R, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Kim DJ, Suk KT. | Curr Issues Mol Biol | 10.3390/cimb44070224 | 2022 | ||
| Genetics | Development of a High-Resolution Single-Nucleotide Polymorphism Strain-Typing Assay Using Whole Genome-Based Analyses for the Lactobacillus acidophilus Probiotic Strain. | Huang CH, Chen CC, Chiu SH, Liou JS, Lin YC, Lin JS, Huang L, Watanabe K. | Microorganisms | 10.3390/microorganisms8091445 | 2020 | |
| Identification of renal protective gut microbiome derived-metabolites in diabetic chronic kidney disease: An integrated approach using network pharmacology and molecular docking. | Saranya GR, Viswanathan P. | Saudi J Biol Sci | 10.1016/j.sjbs.2024.104028 | 2024 | ||
| The identification of metabolites from gut microbiota in NAFLD via network pharmacology. | Oh KK, Gupta H, Min BH, Ganesan R, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Jeong MK, Hyun JY, Eom JA, Park HJ, Yoon SJ, Choi MR, Kim DJ, Suk KT. | Sci Rep | 10.1038/s41598-023-27885-w | 2023 | ||
| 600-ns pulsed electric fields affect inactivation and antibiotic susceptibilities of Escherichia coli and Lactobacillus acidophilus. | Martens SL, Klein S, Barnes RA, TrejoSanchez P, Roth CC, Ibey BL. | AMB Express | 10.1186/s13568-020-00991-y | 2020 | ||
| In Vitro Activity of the Arylaminoartemisinin GC012 against Helicobacter pylori and Its Effects on Biofilm. | Sisto F, Carradori S, D'Alessandro S, Santo N, Lattuada N, Haynes RK, Taramelli D, Grande R. | Pathogens | 10.3390/pathogens11070740 | 2022 | ||
| Metabolism | Lactobacillus acidophilus counteracts inhibition of NHE3 and DRA expression and alleviates diarrheal phenotype in mice infected with Citrobacter rodentium. | Kumar A, Anbazhagan AN, Coffing H, Chatterjee I, Priyamvada S, Gujral T, Saksena S, Gill RK, Alrefai WA, Borthakur A, Dudeja PK. | Am J Physiol Gastrointest Liver Physiol | 10.1152/ajpgi.00173.2016 | 2016 | |
| Enzymology | The domestication of the probiotic bacterium Lactobacillus acidophilus. | Bull MJ, Jolley KA, Bray JE, Aerts M, Vandamme P, Maiden MC, Marchesi JR, Mahenthiralingam E. | Sci Rep | 10.1038/srep07202 | 2014 | |
| Phylogeny | Development of a tiered multilocus sequence typing scheme for members of the Lactobacillus acidophilus complex. | Ramachandran P, Lacher DW, Pfeiler EA, Elkins CA. | Appl Environ Microbiol | 10.1128/aem.02257-13 | 2013 | |
| Metabolism | Lactobacillus acidophilus stimulates the expression of SLC26A3 via a transcriptional mechanism. | Raheja G, Singh V, Ma K, Boumendjel R, Borthakur A, Gill RK, Saksena S, Alrefai WA, Ramaswamy K, Dudeja PK. | Am J Physiol Gastrointest Liver Physiol | 10.1152/ajpgi.00465.2009 | 2010 | |
| Phylogeny | Rapid detection and differentiation of Salmonella species, Salmonella Typhimurium and Salmonella Enteritidis by multiplex quantitative PCR. | Heymans R, Vila A, van Heerwaarden CAM, Jansen CCC, Castelijn GAA, van der Voort M, Biesta-Peters EG. | PLoS One | 10.1371/journal.pone.0206316 | 2018 | |
| Metabolism | Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells. | Arvans D, Jung YC, Antonopoulos D, Koval J, Granja I, Bashir M, Karrar E, Roy-Chowdhury J, Musch M, Asplin J, Chang E, Hassan H. | J Am Soc Nephrol | 10.1681/asn.2016020132 | 2017 | |
| Pathogenicity | Bile-mediated aminoglycoside sensitivity in Lactobacillus species likely results from increased membrane permeability attributable to cholic acid. | Elkins CA, Mullis LB. | Appl Environ Microbiol | 10.1128/aem.70.12.7200-7209.2004 | 2004 | |
| Bifidobacterium animalis subsp. lactis decreases urinary oxalate excretion in a mouse model of primary hyperoxaluria. | Klimesova K, Whittamore JM, Hatch M. | Urolithiasis | 10.1007/s00240-014-0728-2 | 2015 | ||
| Metabolism | Competitive selection of lactic acid bacteria that persist in the human oral cavity. | Snel J, Marco ML, Kingma F, Noordman WM, Rademaker J, Kleerebezem M. | Appl Environ Microbiol | 10.1128/aem.06043-11 | 2011 | |
| Metabolism | S-layer protein of Lactobacillus acidophilus ATCC 4356: purification, expression in Escherichia coli, and nucleotide sequence of the corresponding gene. | Boot HJ, Kolen CP, van Noort JM, Pouwels PH. | J Bacteriol | 10.1128/jb.175.19.6089-6096.1993 | 1993 | |
| Antibacterial activity associated with Lactobacillus acidophilus. | VINCENT JG, VEOMETT RC, RILEY RF. | J Bacteriol | 10.1128/jb.78.4.477-484.1959 | 1959 | ||
| Metabolism | Inhibitory effect of saliva on glutamic acid accumulation by Lactobacillus acidophilus and the role of the lactoperoxidase-thiocyanate system. | Clem WH, Klebanoff SJ. | J Bacteriol | 10.1128/jb.91.5.1848-1853.1966 | 1966 | |
| Enzymology | Antibacterial activity of the purified peroxidase from human parotid saliva. | Slowey RR, Eidelman S, Klebanoff SJ. | J Bacteriol | 10.1128/jb.96.3.575-579.1968 | 1968 | |
| Enzymology | Development of a differential medium for bile salt hydrolase-active Lactobacillus spp. | Dashkevicz MP, Feighner SD. | Appl Environ Microbiol | 10.1128/aem.55.1.11-16.1989 | 1989 | |
| The isolation and cultivation of Lactobacillus bifidus; a comparison of branched and unbranched strains. | NORRIS RF, FLANDERS T, TOMARELLI RM, GYORGY P. | J Bacteriol | 10.1128/jb.60.6.681-696.1950 | 1950 | ||
| Metabolism | Lactobacillus surface layer proteins: structure, function and applications. | Hynonen U, Palva A. | Appl Microbiol Biotechnol | 10.1007/s00253-013-4962-2 | 2013 | |
| Pathogenicity | Isolation and partial amino acid sequence of bacteriocins produced by Lactobacillus acidophilus. | Tahara T, Kanatani K. | Biosci Biotechnol Biochem | 10.1271/bbb.61.884 | 1997 | |
| Apoptosis-Inducing Effects of Short-Chain Fatty Acids-Rich Fermented Pistachio Milk in Human Colon Carcinoma Cells. | Lim SJ, Kwon HC, Shin DM, Choi YJ, Han SG, Kim YJ, Han SG. | Foods | 10.3390/foods12010189 | 2023 | ||
| Phylogeny | Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption. | Mahenthiralingam E, Marchbank A, Drevinek P, Garaiova I, Plummer S. | BMC Microbiol | 10.1186/1471-2180-9-251 | 2009 |
| #20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 ) |
| #38457 | Collection of Institut Pasteur ; Curators of the CIP; CIP 103595 |
| #67770 | Japan Collection of Microorganism (JCM) ; Curators of the JCM; |
| #68371 | Automatically annotated from API 50CH acid . |
| #68382 | Automatically annotated from API zym . |
| #124043 | Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy . |
| #126262 | A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 ) |
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