Lactobacillus acidophilus (CIP 103597, ATCC 832, NCDO 1)

Name: Lactobacillus acidophilus (CIP 103597, ATCC 832, NCDO 1)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 135306

Type strain

Strain Designation 4B

Culture col. no. CIP 103597 ATCC 832 NCDO 1 NCTC 1723 NCIMB 1723 5 more

NCBI tax ID(s) 1579

Special Collections JCM KCTC CIP

History T. Mitsuoka S1-68 <-- M. E. Sharpe A-1 <-- NCTC 1723 <-- L. F. Rettger 4B <-- W. L. Kulp. CIP <- 1992, F. Gasser, Inst. Pasteur, Paris, France: strain VPI 0326, Lactobacillus acidophilus, group A1 <- ATCC <- 1923, L.F. Rettger, Yale: strain 4B <- W.L. Kulp

Links

Lactobacillus acidophilus 4B is a facultative anaerobe, Gram-positive, rod-shaped bacterium that was isolated from Rat feces.

Gram-positive rod-shaped facultative anaerobe 16S sequence Bacteria

Name and taxonomic classification

SI-ID 13694

LMG 11428,ATCC 832,JCM 1023,NCFB 1,NCIMB 1723,NCTC 1723,NCDO 1,NCIB 1723,CIP 103597,KCTC 3142,CECT 4179

@ref 20215

Last LPSN update 2026-02-09 11:32:24

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lactobacillus

Species Lactobacillus acidophilus

Full scientific name Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970 (Approved Lists 1980)

Synonyms (1)

"Bacillus acidophilus"

BacDive ID	Other strains from **Lactobacillus acidophilus** (35)	Type strain
6404	L. acidophilus L917, Scav, DSM 20079, ATCC 4356, NCDO 1748, ... (type strain)
6403	L. acidophilus A 16, DSM 9126, ATCC 13651, NCDO 1360
6405	L. acidophilus DSM 20242, JCM 2124
135119	L. acidophilus CIP 104455
135293	L. acidophilus R-1-1, CIP 103596, ATCC 4355, JCM 1021, KCTC ...
135307	L. acidophilus 43, CIP 103598, ATCC 314, JCM 2121
136312	L. acidophilus CIP 104457, ATCC 11975, NCDO 2, NCTC 1899, ...
137096	L. acidophilus CIP 103600, VPI 11473
137247	L. acidophilus A18, CIP 103601
137642	L. acidophilus Pak, CIP 103595, ATCC 4357, NCDO 1697, NCIMB ...
137667	L. acidophilus 65 AC, CIP 104463
137731	L. acidophilus 184.85, CIP 101490
137879	L. acidophilus 174-86, CIP 102104
137884	L. acidophilus 219-86, CIP 102108
138689	L. acidophilus CIP 102079
141878	L. acidophilus CCUG 8032
142532	L. acidophilus CCUG 12853, LMG 8151
145069	L. acidophilus CCUG 27599
145073	L. acidophilus CCUG 27603
145405	L. acidophilus CCUG 28373
145772	L. acidophilus CCUG 29549 B
146144	L. acidophilus CCUG 30451
146219	L. acidophilus CCUG 30632
147334	L. acidophilus CCUG 33386 A
147807	L. acidophilus CCUG 34264
149472	L. acidophilus CCUG 37804
160902	L. acidophilus JCM 1028, KCTC 3145, LMG 18178
160907	L. acidophilus JCM 1033, KCTC 3150
160908	L. acidophilus JCM 1034, KCTC 3151
160915	L. acidophilus JCM 1035, KCTC 3152
161124	L. acidophilus JCM 11047
161209	L. acidophilus JCM 1229, KCTC 3168
165573	L. acidophilus JCM 7711
170959	L. acidophilus 61N, CRBIP24.117
170960	L. acidophilus A31, CRBIP24.142

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
34390	positive	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Growth	Composition	Medium link
34390	MEDIUM 40- for Lactobacillus and Leuconostoc		Distilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g)
34390	CIP Medium 40			Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
34390	positive	growth	37
34390	positive	growth	30-45
34390	negative	growth	5
34390	negative	growth	10
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

34390

Oxygen tolerancefacultative anaerobe

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	+	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	+	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	+	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
34390	17632 ChEBI	nitrate	+	respiration
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	+	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Enzymes

@ref	Value	Activity	Ec
34390	alcohol dehydrogenase	-	1.1.1.1
34390	catalase	-	1.11.1.6
34390	lysine decarboxylase	-	4.1.1.18
34390	ornithine decarboxylase	-	4.1.1.17
34390	oxidase	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
34390	not determinedn.d.	-	-	-	-	-	-	-	-	-	+/-	+	+	-	-	-	-	-	-	-	-	-	+	+	-	+	+	+	+	+	+/-	+	-	-	-	+	-	-	-	+	+/-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation

@ref	Sample type	Isolation date
67770	Rat feces
34390	Animal, Feces, white rat	1922

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
34390	1	Risk group (French classification)

Sequence information

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Lactobacillus acidophilus gene for 16S rRNA, partial sequence, strain: JCM 1023.	AB289012	675		1579

GC content

@ref	GC-content (mol%)	Method
67770	34	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Enzymology	Microbial Production of Conjugated Linoleic Acid and Conjugated Linolenic Acid Relies on a Multienzymatic System.	Salsinha AS, Pimentel LL, Fontes AL, Gomes AM, Rodriguez-Alcala LM.	Microbiol Mol Biol Rev	10.1128/mmbr.00019-18	2018
	Revalorisation of vine trimming wastes using Lactobacillus acidophilus and Debaryomyces hansenii	Portilla OM, Rivas B, Torrado A, Moldes AB, Dominguez JM.	J Sci Food Agric	10.1002/jsfa.3351	2008
Enzymology	The domestication of the probiotic bacterium Lactobacillus acidophilus.	Bull MJ, Jolley KA, Bray JE, Aerts M, Vandamme P, Maiden MC, Marchesi JR, Mahenthiralingam E.	Sci Rep	10.1038/srep07202	2014
	Gram stains: a resource for retrospective analysis of bacterial pathogens in clinical studies.	Srinivasan U, Ponnaluri S, Villareal L, Gillespie B, Wen A, Miles A, Bucholz B, Marrs CF, Iyer RK, Misra D, Foxman B.	PLoS One	10.1371/journal.pone.0042898	2012
Pathogenicity	Use of a continuous-culture biofilm system to study the antimicrobial susceptibilities of Gardnerella vaginalis and Lactobacillus acidophilus.	Muli F, Struthers JK.	Antimicrob Agents Chemother	10.1128/aac.42.6.1428	1998
Phylogeny	Evaluation of API Coryne system for identifying coryneform bacteria.	Soto A, Zapardiel J, Soriano F.	J Clin Pathol	10.1136/jcp.47.8.756	1994
	A differential microbiological assay for vitamin B12 and pseudovitamin B12.	BERMAN D, YACOWITZ H, WEISER HH.	Appl Microbiol	10.1128/am.4.1.49-52.1956	1956
Enzymology	Development of a differential medium for bile salt hydrolase-active Lactobacillus spp.	Dashkevicz MP, Feighner SD.	Appl Environ Microbiol	10.1128/aem.55.1.11-16.1989	1989
Phylogeny	Deoxyribonucleic acid base composition of the genus Lactobacillus.	Gasser F, Mandel M.	J Bacteriol	10.1128/jb.96.3.580-588.1968	1968
	Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease.	Gillard J, Leclercq IA.	Clin Sci (Lond)	10.1042/cs20220697	2023
	Essential Oils from Ugandan Aromatic Medicinal Plants: Chemical Composition and Growth Inhibitory Effects on Oral Pathogens.	Ocheng F, Bwanga F, Joloba M, Softrata A, Azeem M, Putsep K, Borg-Karlson AK, Obua C, Gustafsson A.	Evid Based Complement Alternat Med	10.1155/2015/230832	2015
Pathogenicity	Antimicrobial activity of polyhexamethylene guanidine phosphate in comparison to chlorhexidine using the quantitative suspension method.	Vitt A, Sofrata A, Slizen V, Sugars RV, Gustafsson A, Gudkova EI, Kazeko LA, Ramberg P, Buhlin K.	Ann Clin Microbiol Antimicrob	10.1186/s12941-015-0097-x	2015
Enzymology	Production and properties of alpha-glucosidase from Lactobacillus acidophilus.	Li KB, Chan KY.	Appl Environ Microbiol	10.1128/aem.46.6.1380-1387.1983	1983
Pathogenicity	Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria.	Sofrata A, Santangelo EM, Azeem M, Borg-Karlson AK, Gustafsson A, Putsep K.	PLoS One	10.1371/journal.pone.0023045	2011
Enzymology	Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora.	Ott SJ, Musfeldt M, Ullmann U, Hampe J, Schreiber S.	J Clin Microbiol	10.1128/jcm.42.6.2566-2572.2004	2004
Phylogeny	Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption.	Mahenthiralingam E, Marchbank A, Drevinek P, Garaiova I, Plummer S.	BMC Microbiol	10.1186/1471-2180-9-251	2009
Metabolism	Lactobacillus surface layer proteins: structure, function and applications.	Hynonen U, Palva A.	Appl Microbiol Biotechnol	10.1007/s00253-013-4962-2	2013
Metabolism	Production of Selenomethionine-Enriched Bifidobacterium bifidum BGN4 via Sodium Selenite Biocatalysis.	Jin W, Yoon C, Johnston TV, Ku S, Ji GE.	Molecules	10.3390/molecules23112860	2018
Pathogenicity	Isolation and partial amino acid sequence of bacteriocins produced by Lactobacillus acidophilus.	Tahara T, Kanatani K.	Biosci Biotechnol Biochem	10.1271/bbb.61.884	1997
Enzymology	Isolation, partial characterization, and mode of action of Acidocin J1132, a two-component bacteriocin produced by Lactobacillus acidophilus JCM 1132.	Tahara T, Oshimura M, Umezawa C, Kanatani K.	Appl Environ Microbiol	10.1128/aem.62.3.892-897.1996	1996
Metabolism	Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus.	Macouzet M, Robert N, Lee BH	Appl Microbiol Biotechnol	10.1007/s00253-010-2634-z	2010
Enzymology	Properties of alpha-glucosidase from Lactobacillus acidophilus NCTC 1723.	Chan K, Li KB	Microbios		1981

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#34390	Collection of Institut Pasteur ; Curators of the CIP; CIP 103597
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lactobacillus acidophilus (CIP 103597, ATCC 832, NCDO 1)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Metabolite utilization

Enzymes

API 50CHac

Isolation, sampling and environmental information

Isolation

Interaction and safety

Risk assessment

Sequence information

16S sequences

GC content

Genome-based predictions

Literature

Literature

References

BacDive

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