Lactobacillus acidophilus (CIP 104457, ATCC 11975, NCDO 2)

Name: Lactobacillus acidophilus (CIP 104457, ATCC 11975, NCDO 2)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 136312

Type strain

Culture col. no. CIP 104457 ATCC 11975 NCDO 2 NCTC 1899 VPI 11084

NCBI tax ID(s) 1579

Special Collections CIP

History CIP <- 1995, F. Gasser, Inst. Pasteur, Paris, France <- J.L. Johnson, Blacksburg, USA: strain VPI 11084

Links

Lactobacillus acidophilus CIP 104457 is a facultative anaerobe, Gram-positive, rod-shaped bacterium of the family Lactobacillaceae.

Gram-positive rod-shaped facultative anaerobe Bacteria

Name and taxonomic classification

SI-ID 44412

ATCC 11975,NCIB 1899,NCDO 2,CIP 104457,NCTC 1899,NCIMB 1899,VKM B-1918,NCIM 2660

@ref 20215

Last LPSN update 2026-02-09 11:32:37

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lactobacillus

Species Lactobacillus acidophilus

Full scientific name Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970 (Approved Lists 1980)

Synonyms (1)

"Bacillus acidophilus"

BacDive ID	Other strains from **Lactobacillus acidophilus** (35)	Type strain
6404	L. acidophilus L917, Scav, DSM 20079, ATCC 4356, NCDO 1748, ... (type strain)
6403	L. acidophilus A 16, DSM 9126, ATCC 13651, NCDO 1360
6405	L. acidophilus DSM 20242, JCM 2124
135119	L. acidophilus CIP 104455
135293	L. acidophilus R-1-1, CIP 103596, ATCC 4355, JCM 1021, KCTC ...
135306	L. acidophilus 4B, CIP 103597, ATCC 832, NCDO 1, NCTC 1723, ...
135307	L. acidophilus 43, CIP 103598, ATCC 314, JCM 2121
137096	L. acidophilus CIP 103600, VPI 11473
137247	L. acidophilus A18, CIP 103601
137642	L. acidophilus Pak, CIP 103595, ATCC 4357, NCDO 1697, NCIMB ...
137667	L. acidophilus 65 AC, CIP 104463
137731	L. acidophilus 184.85, CIP 101490
137879	L. acidophilus 174-86, CIP 102104
137884	L. acidophilus 219-86, CIP 102108
138689	L. acidophilus CIP 102079
141878	L. acidophilus CCUG 8032
142532	L. acidophilus CCUG 12853, LMG 8151
145069	L. acidophilus CCUG 27599
145073	L. acidophilus CCUG 27603
145405	L. acidophilus CCUG 28373
145772	L. acidophilus CCUG 29549 B
146144	L. acidophilus CCUG 30451
146219	L. acidophilus CCUG 30632
147334	L. acidophilus CCUG 33386 A
147807	L. acidophilus CCUG 34264
149472	L. acidophilus CCUG 37804
160902	L. acidophilus JCM 1028, KCTC 3145, LMG 18178
160907	L. acidophilus JCM 1033, KCTC 3150
160908	L. acidophilus JCM 1034, KCTC 3151
160915	L. acidophilus JCM 1035, KCTC 3152
161124	L. acidophilus JCM 11047
161209	L. acidophilus JCM 1229, KCTC 3168
165573	L. acidophilus JCM 7711
170959	L. acidophilus 61N, CRBIP24.117
170960	L. acidophilus A31, CRBIP24.142

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
35679	positive	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Growth	Composition	Medium link
35679	MEDIUM 40- for Lactobacillus and Leuconostoc		Distilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g)
35679	CIP Medium 40			Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
35679	positive	growth	37
35679	positive	growth	37-45
35679	negative	growth	15

Physiology and metabolism

Oxygen tolerance

35679

Oxygen tolerancefacultative anaerobe

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
35679	17632 ChEBI	nitrate	-	reduction
35679	17632 ChEBI	nitrate	+	respiration
35679	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	+	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
35679	15688 ChEBI	acetoin	-

Enzymes

@ref	Value	Activity	Ec
35679	alcohol dehydrogenase	-	1.1.1.1
35679	catalase	-	1.11.1.6
35679	lysine decarboxylase	-	4.1.1.18
35679	ornithine decarboxylase	-	4.1.1.17
35679	oxidase	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
35679	not determinedn.d.	-	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+/-	-	+/-	+	+/-	+/-	+	+	+/-	+	+	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
35679	1	Risk group (French classification)

Sequence information

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Potential of jackfruit inner skin fibre for encapsulation of probiotics on their stability against adverse conditions.	Petsong K, Kaewthong P, Kingwascharapong P, Nilsuwan K, Karnjanapratum S, Tippayawat P.	Sci Rep	10.1038/s41598-023-38319-y	2023
	Bovine Milk and Yogurt Affect Oral Microorganisms and Biofilms In-Vitro.	Tennert C, Sarra G, Stahli A, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.b3920023	2023
	Comparison of Antibacterial Activity, Cytotoxicity, and Fluoride Release of Glass Ionomer Restorative Dental Cements in Dentistry.	Gunay A, Celenk S, Adiguzel O, Cangul S, Ozcan N, Eroglu Cakmakoglu E.	Med Sci Monit	10.12659/msm.939065	2023
	Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox.	Jeyakumar J, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.a45437	2020
Pathogenicity	Impact of honey on dental erosion and adhesion of early bacterial colonizers.	Habluetzel A, Schmid C, Carvalho TS, Lussi A, Eick S.	Sci Rep	10.1038/s41598-018-29188-x	2018
Pathogenicity	Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumor immunity in a mouse colon cancer model.	Zhuo Q, Yu B, Zhou J, Zhang J, Zhang R, Xie J, Wang Q, Zhao S.	Sci Rep	10.1038/s41598-019-56661-y	2019
	Comparative Evaluation of Antimicrobial Efficacy and Fluoride Release of Seven Different Glass-Ionomer-Based Restorative Materials.	Sagmak S, Bahsi E, Ozcan N, Satici O.	Oral Health Prev Dent	10.3290/j.ohpd.a44140	2020
Metabolism	The influences of fish infusion broth on the biogenic amines formation by lactic acid bacteria.	Kuley E, Ozogul F, Balikci E, Durmus M, Ayas D.	Braz J Microbiol	10.1590/s1517-83822013000200010	2013
	Invitro synergistic activity of lactic acid bacteria against multi-drug resistant staphylococci.	Bhola J, Bhadekar R.	BMC Complement Altern Med	10.1186/s12906-019-2470-3	2019
	In Vitro Activity of Propolis on Oral Microorganisms and Biofilms.	Stahli A, Schroter H, Bullitta S, Serralutzu F, Dore A, Nietzsche S, Milia E, Sculean A, Eick S.	Antibiotics (Basel)	10.3390/antibiotics10091045	2021
	Pellicle Modification with Casein and Mucin Does Not Promote In Vitro Bacterial Biofilm Formation.	Carvalho TS, Halter JE, Mucolli D, Lussi A, Eick S, Baumann T.	Oral Health Prev Dent	10.3290/j.ohpd.a43351	2020
Metabolism	Commensal-epithelial signaling mediated via formyl peptide receptors.	Wentworth CC, Jones RM, Kwon YM, Nusrat A, Neish AS.	Am J Pathol	10.2353/ajpath.2010.100529	2010
Genetics	Similarity and differences in the Lactobacillus acidophilus group identified by polyphasic analysis and comparative genomics.	Berger B, Pridmore RD, Barretto C, Delmas-Julien F, Schreiber K, Arigoni F, Brussow H.	J Bacteriol	10.1128/jb.01393-06	2007
	Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.	Conte MP, Schippa S, Zamboni I, Penta M, Chiarini F, Seganti L, Osborn J, Falconieri P, Borrelli O, Cucchiara S.	Gut	10.1136/gut.2005.078824	2006
	The vaginal microflora in relation to gingivitis.	Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D.	BMC Infect Dis	10.1186/1471-2334-9-6	2009
Pathogenicity	Development of dual-acting pyrimidinediones as novel and highly potent topical anti-HIV microbicides.	Watson Buckheit K, Yang L, Buckheit RW.	Antimicrob Agents Chemother	10.1128/aac.05237-11	2011
Metabolism	Cloning, expression, and nucleotide sequence of the Lactobacillus helveticus 481 gene encoding the bacteriocin helveticin J.	Joerger MC, Klaenhammer TR.	J Bacteriol	10.1128/jb.172.11.6339-6347.1990	1990
	Lactobacillus plantarum ldhL gene: overexpression and deletion.	Ferain T, Garmyn D, Bernard N, Hols P, Delcour J.	J Bacteriol	10.1128/jb.176.3.596-601.1994	1994
Enzymology	Bacterial lactate dehydrogenases.	Garvie EI.	Microbiol Rev	10.1128/mr.44.1.106-139.1980	1980
	Derivation of DNA probes for enumeration of a specific strain of Lactobacillus acidophilus in piglet digestive tract samples.	Rodtong S, Dobbinson S, Thode-Andersen S, McConnell MA, Tannock GW.	Appl Environ Microbiol	10.1128/aem.59.11.3871-3877.1993	1993
Phylogeny	Differentiation of Lactobacillus strains by ribotyping.	Rodtong S, Tannock GW.	Appl Environ Microbiol	10.1128/aem.59.10.3480-3484.1993	1993
	Synergistic lysis of erythrocytes by Propionibacterium acnes.	Choudhury TK.	J Clin Microbiol	10.1128/jcm.8.2.238-241.1978	1978

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#35679	Collection of Institut Pasteur ; Curators of the CIP; CIP 104457
#68371	Automatically annotated from API 50CH acid .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lactobacillus acidophilus (CIP 104457, ATCC 11975, NCDO 2)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Metabolite utilization

Metabolite tests

Enzymes

API 50CHac

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

Sequence information

Genome-based predictions

Literature

Literature

References

BacDive

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