Amycolatopsis orientalis (DSM 40040, ATCC 19795, CBS 547.68)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	9119
  multimedia content:	DSM_40040.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40040.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
19392	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19392	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19392	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19392	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19392	ISP 6			Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19392	ISP 7			Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
38186	MEDIUM 57 - for Streptomyces, Nocardioides, Lentzea albidocapillata and Streptoverticillium reticulum			Distilled water make up to (1000.000 ml);Agar (15.000 g);Glucose (4.000g);Yeast extract (4.000 g);Malt extract (10.000 g);Calcium carbonate (2.000 g)
9119	TRYPTICASE SOY BROTH AGAR (DSMZ Medium 535)		Medium recipe at MediaDive	Name: TRYPTICASE SOY BROTH AGAR (DSMZ Medium 535) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Distilled water
9119	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
121436	CIP Medium 57		Medium recipe at CIP

Culture temp

Oxygen tolerance

Spore formation

Compound production

Halophily

Observation

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68369	17128 ChEBI	adipate	+	assimilation	from API 20NE
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
19392	22599 ChEBI	arabinose	+
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
19392	62968 ChEBI	cellulose	-
121436	16947 ChEBI	citrate	-	carbon source
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	-	builds acid from	from API 50CH acid
68369	17634 ChEBI	D-glucose	+	assimilation	from API 20NE
68369	17634 ChEBI	D-glucose	-	fermentation	from API 20NE
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68369	16899 ChEBI	D-mannitol	+	assimilation	from API 20NE
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68369	16024 ChEBI	D-mannose	+	assimilation	from API 20NE
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68369	27689 ChEBI	decanoate	-	assimilation	from API 20NE
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
121436	4853 ChEBI	esculin	+	hydrolysis
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68369	4853 ChEBI	esculin	+	hydrolysis	from API 20NE
19392	28757 ChEBI	fructose	-
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68369	5291 ChEBI	gelatin	+	hydrolysis	from API 20NE
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68369	24265 ChEBI	gluconate	+	assimilation	from API 20NE
19392	17234 ChEBI	glucose	+
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
121436	606565 ChEBI	hippurate	+	hydrolysis
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68369	30849 ChEBI	L-arabinose	+	assimilation	from API 20NE
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68368	25094 ChEBI	lysine	-	degradation	from API 20E
68369	25115 ChEBI	malate	+	assimilation	from API 20NE
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
19392	29864 ChEBI	mannitol	+
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
19392	17268 ChEBI	myo-inositol	+
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
68369	59640 ChEBI	N-acetylglucosamine	+	assimilation	from API 20NE
121436	17632 ChEBI	nitrate	+	reduction
121436	17632 ChEBI	nitrate	-	respiration
68369	17632 ChEBI	nitrate	+	reduction	from API 20NE
121436	16301 ChEBI	nitrite	-	reduction
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
19392	16634 ChEBI	raffinose	-
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
19392	26546 ChEBI	rhamnose	-
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
19392	17992 ChEBI	sucrose	-
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68369	27897 ChEBI	tryptophan	-	energy source	from API 20NE
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68369	16199 ChEBI	urea	+	hydrolysis	from API 20NE
68368	16199 ChEBI	urea	-	hydrolysis	from API 20E
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid
19392	18222 ChEBI	xylose	-

Antibiotic resistance

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68369	35581 ChEBI	indole		from API 20NE
121436	35581 ChEBI	indole
68368	35581 ChEBI	indole		from API 20E
67770	28001 ChEBI	vancomycin

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	-		from API 20E
68369	35581 ChEBI	indole		-	from API 20NE
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
121436	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
121436	amylase	+
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
121436	beta-galactosidase	+	3.2.1.23
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68369	beta-glucosidase	+	3.2.1.21	from API 20NE
68382	beta-glucuronidase	-	3.2.1.31	from API zym
121436	caseinase	+	3.4.21.50
121436	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
121436	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
121436	gamma-glutamyltransferase	+	2.3.2.2
121436	gelatinase	+
68369	gelatinase	+		from API 20NE
68368	gelatinase	+		from API 20E
121436	lecithinase	+
121436	lipase	-
68382	lipase (C 14)	-		from API zym
121436	lysine decarboxylase	-	4.1.1.18
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
121436	ornithine decarboxylase	-	4.1.1.17
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
121436	oxidase	-
121436	phenylalanine ammonia-lyase	-	4.3.1.24
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
121436	tween esterase	+
121436	urease	+	3.5.1.5
68369	urease	+	3.5.1.5	from API 20NE
68368	urease	-	3.5.1.5	from API 20E

API 20E

API zym

API 20NE

API 50CHac

API biotype100

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence AJ400711 (>99% sequence identity) for Amycolatopsis from Microbeatlas

Aquatic Samples	14
Soil Samples	213
Animal Samples	67
Plant Samples	25
Total Samples	319

Risk assessment

Phages

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	AO9412_01 assembly for Amycolatopsis orientalis DSM 40040 = KCTC 9412	contig	GCA_000478275	1125971.3	2554235102	1125971	59.17

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Amycolatopsis orientalis partial 16S rRNA gene, strain IMSNU 20058T	AJ400711	1458		31958
20218	Amycolatopsis orientalis gene for 16S ribosomal RNA, partial sequence, strain: JCM 4235	D44036	120		31958
20218	Amycolatopsis orientalis gene for 16S ribosomal RNA, partial sequence	D86935	1467		31958
20218	A.orientalis (ssp. orientalis DSM 40040) 16S ribosomal RNA (partial)	X76958	1444		31958
124043	Amycolatopsis orientalis strain DSM 40040(T) VINDHYACHAL 16S ribosomal RNA gene, partial sequence.	MN134083	1421		31958

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae.	Kovacs-Valasek M, Fekete C, Kovacs-Valasek A.	Heliyon	10.1016/j.heliyon.2024.e41065	2025
	Revisiting D-Acylases for D-Amino Acid Production.	Martinez-Rodriguez S, Gavira JA.	Microb Biotechnol	10.1111/1751-7915.70179	2025
	The Impact of Heterologous Regulatory Genes from Lipodepsipeptide Biosynthetic Gene Clusters on the Production of Teicoplanin and A40926.	Zhukrovska K, Binda E, Fedorenko V, Marinelli F, Yushchuk O.	Antibiotics (Basel)	10.3390/antibiotics13020115	2024
	Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery.	Fernandes GFS, Kim SH, Castagnolo D.	RSC Adv	10.1039/d4ra04824e	2024
	Glycopeptide Antibiotic Resistance Genes: Distribution and Function in the Producer Actinomycetes.	Yushchuk O, Binda E, Marinelli F.	Front Microbiol	10.3389/fmicb.2020.01173	2020
	Expression of Genes for a Flavin Adenine Dinucleotide-Binding Oxidoreductase and a Methyltransferase from Mycobacterium chlorophenolicum Is Necessary for Biosynthesis of 10-Methyl Stearic Acid from Oleic Acid in Escherichia coli.	Machida S, Bakku RK, Suzuki I.	Front Microbiol	10.3389/fmicb.2017.02061	2017
	Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB.	Forneris CC, Ozturk S, Sorensen EJ, Seyedsayamdost MR.	Tetrahedron	10.1016/j.tet.2018.04.028	2018
Genetics	Genetics and Genomics of the Genus Amycolatopsis.	Kumari R, Singh P, Lal R.	Indian J Microbiol	10.1007/s12088-016-0590-8	2016
Phylogeny	Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species.	Adamek M, Alanjary M, Sales-Ortells H, Goodfellow M, Bull AT, Winkler A, Wibberg D, Kalinowski J, Ziemert N.	BMC Genomics	10.1186/s12864-018-4809-4	2018
Enzymology	The genus Amycolatopsis: Indigenous plasmids, cloning vectors and gene transfer systems.	Malhotra S, Lal R.	Indian J Microbiol	10.1007/s12088-007-0003-0	2007
	A novel method to generate unmarked gene deletions in the intracellular pathogen Rhodococcus equi using 5-fluorocytosine conditional lethality.	van der Geize R, de Jong W, Hessels GI, Grommen AW, Jacobs AA, Dijkhuizen L.	Nucleic Acids Res	10.1093/nar/gkn811	2008
Metabolism	Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria.	Dubeau MP, Ghinet MG, Jacques PE, Clermont N, Beaulieu C, Brzezinski R.	Appl Environ Microbiol	10.1128/aem.02139-08	2009
	Efficient transformation of Amycolatopsis orientalis (Nocardia orientalis) protoplasts by Streptomyces plasmids.	Matsushima P, McHenney MA, Baltz RH.	J Bacteriol	10.1128/jb.169.5.2298-2300.1987	1987
Pathogenicity	Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria.	Dutka-Malen S, Leclercq R, Coutant V, Duval J, Courvalin P.	Antimicrob Agents Chemother	10.1128/aac.34.10.1875	1990
	Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.	Pelzer S, Sussmuth R, Heckmann D, Recktenwald J, Huber P, Jung G, Wohlleben W.	Antimicrob Agents Chemother	10.1128/aac.43.7.1565	1999
	Novel actinomycete isolated from bulking industrial sludge.	White JM, Labeda DP, Lechevalier MP, Owens JR, Jones DD, Gauthier JJ.	Appl Environ Microbiol	10.1128/aem.52.6.1324-1330.1986	1986
Metabolism	Degradation of 1,4-dioxane by an actinomycete in pure culture.	Parales RE, Adamus JE, White N, May HD.	Appl Environ Microbiol	10.1128/aem.60.12.4527-4530.1994	1994
Enzymology	Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis.	Kelly WL, Townsend CA.	J Bacteriol	10.1128/jb.187.2.739-746.2005	2005
	Current perspectives on glycopeptide resistance.	Woodford N, Johnson AP, Morrison D, Speller DC.	Clin Microbiol Rev	10.1128/cmr.8.4.585	1995
Metabolism	Enzymes of glucose and methanol metabolism in the actinomycete Amycolatopsis methanolica.	Alves AM, Euverink GJ, Hektor HJ, Hessels GI, van der Vlag J, Vrijbloed JW, Hondmann D, Visser J, Dijkhuizen L.	J Bacteriol	10.1128/jb.176.22.6827-6835.1994	1994
Metabolism	Denitrification by actinomycetes and purification of dissimilatory nitrite reductase and azurin from Streptomyces thioluteus.	Shoun H, Kano M, Baba I, Takaya N, Matsuo M.	J Bacteriol	10.1128/jb.180.17.4413-4415.1998	1998
Phylogeny	Distribution and phylogenetic analysis of family 19 chitinases in Actinobacteria.	Kawase T, Saito A, Sato T, Kanai R, Fujii T, Nikaidou N, Miyashita K, Watanabe T.	Appl Environ Microbiol	10.1128/aem.70.2.1135-1144.2004	2004
	Design and Synthesis of d-Ala-d-Ala Silica Gel for a Binding Mode-Based Physicochemical Screening Method.	Kimishima A, Suzuki Y, Kosaka S, Honsho M, Honma S, Sakai K, Tsutsumi H, Inahashi Y, Watanabe Y, Iwatsuki M, Asami Y, Nakashima T.	ACS Omega	10.1021/acsomega.3c03837	2023
	Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling.	O'Rourke A, Beyhan S, Choi Y, Morales P, Chan AP, Espinoza JL, Dupont CL, Meyer KJ, Spoering A, Lewis K, Nierman WC, Nelson KE.	Antimicrob Agents Chemother	10.1128/aac.01207-19	2020
	Enzymatic degradation of polylactic acid using a serine protease from Amycolatopsis orientalis: characterization and degradation mechanism.	Zhang W, Li C, Liang H, Wang Z.	Int J Biol Macromol	10.1016/j.ijbiomac.2025.144410	2025
	Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation.	Zhang JG, Huang X.	J Am Chem Soc	10.1021/jacs.4c18532	2025
	Reprogramming nonheme iron enzymes for abiotic alkene trifluoromethylazidation.	Zhang JG, Huang X.	Methods Enzymol	10.1016/bs.mie.2025.06.041	2025
Enzymology	Biocatalytic Olefin Difunctionalization for Synthesis of Chiral 2-Azidoamines Using Nonheme Iron Enzymes.	Huls AJ, Soler J, Su Y, Yang Y, Garcia-Borras M, Huang X.	Angew Chem Int Ed Engl	10.1002/anie.202423403	2025
	Optimizing thermal and thermal-alkaline pretreatments for polylactic acid biodegradation by Amycolatopsis orientalis and Amycolatopsis thailandensis.	Yasin NM, Polanska M, Verbeken K, Van Impe JFM, Akkermans S.	Bioresour Technol	10.1016/j.biortech.2025.132114	2025
	The Roles of Carbon-Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis.	Mani V, Jeyachandran S, Aman M.	Microbiologyopen	10.1002/mbo3.70072	2025
	Biocatalytic Generation of Trifluoromethyl Radicals by Nonheme Iron Enzymes for Enantioselective Alkene Difunctionalization.	Zhang JG, Huls AJ, Palacios PM, Guo Y, Huang X.	J Am Chem Soc	10.1021/jacs.4c14310	2024
	Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis.	Zhao X, Zhu C, Gao W, Xie H, Lyu Z, Zhao Q, Li Y.	Microb Cell Fact	10.1186/s12934-024-02464-4	2024
	Novel methods to monitor the biodegradation of polylactic acid (PLA) by Amycolatopsis orientalis and Amycolatopsis thailandensis.	Yasin NM, Pancho F, Yasin M, Van Impe JFM, Akkermans S.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1355050	2024
Metabolism	Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Amycolatopsis orientalis Based on the CRISPR-Cas12a System.	Qian H, Wei W, Chen XA, Mo XT, Ge M, Zhao QW, Li YQ.	ACS Synth Biol	10.1021/acssynbio.1c00317	2021
	Vancomycin Flushing Syndrome: A Case Report.	Shrivastava S, Shrivastava S.	Cureus	10.7759/cureus.58487	2024
Enzymology	A Four-Step Enzymatic Cascade for Efficient Production of L-Phenylglycine from Biobased L-Phenylalanine.	Zhu Y, Yuan J.	Chembiochem	10.1002/cbic.202100661	2022
Metabolism	Four-Step Pathway from Phenylpyruvate to Benzylamine, an Intermediate to the High-Energy Propellant CL-20.	Pandey RP, Casini A, Voigt CA, Gordon DB.	ACS Synth Biol	10.1021/acssynbio.1c00021	2021
	Production of aromatic amino acids and their derivatives by Escherichia coli and Corynebacterium glutamicum.	Hirasawa T, Satoh Y, Koma D.	World J Microbiol Biotechnol	10.1007/s11274-025-04264-3	2025
Enzymology	A Quantum Mechanical Approach to The Mechanism of Asymmetric Synthesis of Chiral Amine by Imine Reductase from Stackebrandtia Nassauensis.	Kopar M, Senyurt Tuzun N.	Chempluschem	10.1002/cplu.202400606	2025
	Development and Validation of Liquid Chromatographic Method for Fast Determination of Lincomycin, Polymyxin and Vancomycin in Preservation Solution for Transplants.	Lin Q, Nguyen T, Staffieri C, Van Schepdael A, Adams E.	Molecules	10.3390/molecules29133166	2024
Enzymology	Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis.	Prejano M, Sheng X, Himo F.	ChemistryOpen	10.1002/open.202100250	2022
	Functionalizing Nisin with a Sugar Moiety Improves Its Solubility and Results in an Altered Antibacterial Spectrum and Mode of Action.	Guo L, Kuipers OP, Broos J.	ACS Synth Biol	10.1021/acssynbio.5c00353	2025
Enzymology	Enhancement of A82846B yield and proportion by overexpressing the halogenase gene in Amycolatopsis orientalis SIPI18099.	Wang WY, Yang SB, Wu YJ, Shen XF, Chen SX.	Appl Microbiol Biotechnol	10.1007/s00253-018-8983-8	2018
Metabolism	Role of two 5-aminolevulinic acid biosynthetic pathways in heme and secondary metabolite biosynthesis in Amycolatopsis orientalis.	Zhu L, Qian X, Chen D, Ge M.	J Basic Microbiol	10.1002/jobm.201600758	2018
	Current Knowledge on CRISPR Strategies Against Antimicrobial-Resistant Bacteria.	de la Fuente Tagarro C, Martin-Gonzalez D, De Lucas A, Bordel S, Santos-Beneit F.	Antibiotics (Basel)	10.3390/antibiotics13121141	2024
	Antibacterial activity of soil-isolated Bacillus altitudinis/pumilus complex against methicillin-resistant Staphylococcus aureus from Mwanza, Tanzania.	Abednego RN, Silago V.	Afr J Lab Med	10.4102/ajlm.v12i1.2167	2023
Phylogeny	Phylogenetic Analysis of the Genes in D-Ala-D-Lactate Synthesizing Glycopeptide Resistance Operons: The Different Origins of Functional and Regulatory Genes.	Kardos G, Laczko L, Kaszab E, Timmer B, Szarka K, Prepost E, Banyai K.	Antibiotics (Basel)	10.3390/antibiotics13070573	2024
	Microbial synthesis of 4-hydroxybenzoic acid from renewable feedstocks.	Chen Y, Chen Y, Liu L, Zhang Y, Yuan J.	Food Chem (Oxf)	10.1016/j.fochms.2021.100059	2021
	Vancomycin-Induced Fever and Neutropenia in an Immunocompetent Patient With Complicated Community-Acquired Pneumonia.	Alharbi HH, Al-Qurainees GI, Al-Hebshi A.	Cureus	10.7759/cureus.26630	2022
	Amycolatopsis from Desert Specialist Fungus-Growing Ants Suppresses Contaminant Fungi Using the Antibiotic ECO-0501.	Kim JH, Scherer G, Lumpkin DS, Rao K, Puentes Flores CD, Van Arnam EB.	Appl Environ Microbiol	10.1128/aem.01838-22	2023
	Anti-Microbial Activities of Mussel-Derived Recombinant Proteins against Gram-Negative Bacteria.	Kim DY, Oh YB, Park JS, Min YH, Park MC.	Antibiotics (Basel)	10.3390/antibiotics13030239	2024
	A Combinatorial Approach of High-Throughput Genomics and Mass Proteomics for Understanding the Regulation and Expression of Secondary Metabolite Production in Actinobacteria.	Gupta V, Singhvi N.	mSystems	10.1128/msystems.00862-21	2021
Metabolism	Discovery of the New Plant Growth-Regulating Compound LYXLF2 Based on Manipulating the Halogenase in Amycolatopsis orientalis.	Xu L, Han T, Ge M, Zhu L, Qian X.	Curr Microbiol	10.1007/s00284-016-1052-6	2016
Metabolism	Increased vancomycin production by overexpression of MbtH-like protein in Amycolatopsis orientalis KFCC10990P.	Lee KS, Lee BM, Ryu JH, Kim DH, Kim YH, Lim SK.	Lett Appl Microbiol	10.1111/lam.12617	2016
	Antibacterial Conjugates of Kanamycin A with Vancomycin and Eremomycin: Biological Activity and a New MS-Fragmentation Pattern of Cbz-Protected Amines.	Solyev PN, Isakova EB, Olsufyeva EN.	Antibiotics (Basel)	10.3390/antibiotics12050894	2023
	An overview of the factors playing a role in cytochrome P450 monooxygenase and ferredoxin interactions.	Chiliza ZE, Martinez-Oyanedel J, Syed K.	Biophys Rev	10.1007/s12551-020-00749-7	2020
	Identification of Antimicrobial Metabolites from the Egyptian Soil-Derived Amycolatopsis keratiniphila Revealed by Untargeted Metabolomics and Molecular Docking.	Hamed AA, Mohamed OG, Aboutabl EA, Fathy FI, Fawzy GA, El-Shiekh RA, Al-Karmalawy AA, Al-Taweel AM, Tripathi A, Elsayed TR.	Metabolites	10.3390/metabo13050620	2023
Metabolism	Engineering of hydroxymandelate synthases and the aromatic amino acid pathway enables de novo biosynthesis of mandelic and 4-hydroxymandelic acid with Saccharomyces cerevisiae.	Reifenrath M, Boles E.	Metab Eng	10.1016/j.ymben.2018.01.001	2018
	Characterization of plasmid pXL100 from Amycolatopsis orientalis HCCB10007 and construction of a shuttle vector.	Xu L, Li Y, Zhu L, Zhao W, Chen D, Huang W, Yang S.	J Basic Microbiol	10.1002/jobm.201400210	2015
Genetics	Genome assembly, comparative genomics, and identification of genes/pathways underlying plant growth-promoting traits of an actinobacterial strain, Amycolatopsis sp. (BCA-696).	Gandham P, Vadla N, Saji A, Srinivas V, Ruperao P, Selvanayagam S, Saxena RK, Rathore A, Gopalakrishnan S, Thakur V.	Sci Rep	10.1038/s41598-024-66835-y	2024
	Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.	Wang P, Zhang X, Tao Y, Lv X, Cheng S, Liu C.	Synth Syst Biotechnol	10.1016/j.synbio.2021.12.008	2022
	Modification of Biphenolic Anti-Bacterial to Achieve Broad-Spectrum Activity.	Ochoa C, Roenfanz HF, Kozlowski MC.	ChemMedChem	10.1002/cmdc.202100783	2022
	Effects of Nitrogen Accumulation, Transportation, and Grain Nutritional Quality and Advances in Fungal Endophyte Research in Quinoa (Chenopodium quinoa Willd.) Plants.	Li L, Jiang Z, Yang X, Zhang Y, Huang J, Dai J, Noor H, Wu X, Ren A, Gao Z, Sun M.	J Fungi (Basel)	10.3390/jof10070504	2024
Metabolism	Sequence-based screening and characterization of cytosolic mandelate oxidase using oxygen as electron acceptor.	Liu SP, Liu RX, Zhang L, Shi GY.	Enzyme Microb Technol	10.1016/j.enzmictec.2014.11.001	2015
Metabolism	Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152.	Zhu X, Siitonen V, Melancon Iii CE, Metsa-Ketela M.	ACS Synth Biol	10.1021/acssynbio.0c00482	2021
	The bactericidal effect of vancomycin is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro.	Schwerdt C, Rohner E, Bohle S, Jacob B, Matziolis G.	Sci Rep	10.1038/s41598-021-90302-7	2021
Metabolism	A regulatory gene (ECO-orf4) required for ECO-0501 biosynthesis in Amycolatopsis orientalis.	Shen Y, Huang H, Zhu L, Luo M, Chen D.	J Basic Microbiol	10.1002/jobm.201200314	2014
Genetics	Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters.	Sanchez-Hidalgo M, Garcia MJ, Gonzalez I, Oves-Costales D, Genilloud O.	Microorganisms	10.3390/microorganisms11020265	2023
	Minimal aromatic aldehyde reduction (MARE) yeast platform for engineering vanillin production.	Mo Q, Yuan J.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02454-5	2024
	From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota.	Tahmasebi H, Arjmand N, Monemi M, Babaeizad A, Alibabaei F, Alibabaei N, Bahar A, Oksenych V, Eslami M.	Biomolecules	10.3390/biom15010093	2025
	Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01)	Shen Y, Huang H, Zhu L, Luo M, Chen D.	Biotechnol Lett		2012
Enzymology	Metabolic engineering of Escherichia coli for high-level production of benzyl acetate from glucose.	Ke Q, Liu C, Zhuang Y, Xue Y, Cui Z, Zhang C, Yin H, Liu T.	Microb Cell Fact	10.1186/s12934-024-02513-y	2024
Metabolism	Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01).	Shen Y, Huang H, Zhu L, Luo M, Chen D.	Biotechnol Lett	10.1007/s10529-012-1010-8	2012
Metabolism	Identification of a gene responsible for amido black decolorization isolated from Amycolatopsis orientalis.	Chengalroyen MD, Dabbs ER.	World J Microbiol Biotechnol	10.1007/s11274-012-1218-8	2013
	Genome Sequences of Amycolatopsis orientalis subsp. orientalis Strains DSM 43388 and DSM 46075.	Jeong H, Sim YM, Kim HJ, Lee YJ, Lee DW, Lim SK, Lee SJ.	Genome Announc	10.1128/genomea.00545-13	2013
Metabolism	Heterologous pathway for the production of L-phenylglycine from glucose by E. coli.	Liu SP, Liu RX, El-Rotail AA, Ding ZY, Gu ZH, Zhang L, Shi GY.	J Biotechnol	10.1016/j.jbiotec.2014.06.033	2014
	Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica.	Ordonez-Enireb E, Cucalon RV, Cardenas D, Ordonez N, Coello S, Elizalde P, Cardenas WB.	Sci Rep	10.1038/s41598-022-25911-x	2022
Metabolism	Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis.	Song Z, Xu T, Wang J, Hou Y, Liu C, Liu S, Wu S.	Molecules	10.3390/molecules26071884	2021
	Integrating vectors for genetic studies in the rare Actinomycete Amycolatopsis marina.	Gao H, Murugesan B, Hossbach J, Evans SK, Stark WM, Smith MCM.	BMC Biotechnol	10.1186/s12896-019-0521-y	2019
Metabolism	Pentose phosphate pathway flux analysis for glycopeptide antibiotic vancomycin production during glucose-limited cultivation of Amycolatopsis orientalis.	Ayar-Kayali H.	Prep Biochem Biotechnol	10.1080/10826068.2010.535401	2011
	Genetics Behind the Glycosylation Patterns in the Biosynthesis of Dalbaheptides.	Yushchuk O, Zhukrovska K, Berini F, Fedorenko V, Marinelli F.	Front Chem	10.3389/fchem.2022.858708	2022
	Structure of EvaA: a paradigm for sugar 2,3-dehydratases.	Kubiak RL, Thoden JB, Holden HM.	Biochemistry	10.1021/bi400176n	2013
Enzymology	Predicting Antibiotic Effect of Vancomycin Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation: Dense Sampling versus Sparse Sampling.	Kim YK, Lee JH, Jang HJ, Zang DY, Lee DH.	Antibiotics (Basel)	10.3390/antibiotics11060743	2022
	Polymeric Anti-Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution.	Koshani R, Yeh SL, He Z, Narasimhalu N, Vom Steeg LG, Sim DG, Woods RJ, Read AF, Sheikhi A.	Small	10.1002/smll.202407549	2025
Enzymology	Biochemical characterization of a glycosyltransferase Gtf3 from Mycobacterium smegmatis: a case study of improved protein solubilization.	Bakli M, Karim L, Mokhtari-Soulimane N, Merzouk H, Vincent F.	3 Biotech	10.1007/s13205-020-02431-x	2020
Enzymology	Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases.	Cross AR, Roy S, Vivoli Vega M, Rejzek M, Nepogodiev SA, Cliff M, Salmon D, Isupov MN, Field RA, Prior JL, Harmer NJ, GoVV consortium.	J Biol Chem	10.1016/j.jbc.2022.101903	2022
	Identification of a novel xanthan-binding module of a multi-modular Cohnella sp. xanthanase.	Han R, Baudrexl M, Ludwig C, Berezina OV, Rykov SV, Liebl W.	Front Microbiol	10.3389/fmicb.2024.1386552	2024
	Antimicrobial Efficacy of 7-Hydroxyflavone Derived from Amycolatopsis sp. HSN-02 and Its Biocontrol Potential on Cercospora Leaf Spot Disease in Tomato Plants.	Math HH, Kumar RS, Chakraborty B, Almansour AI, Perumal K, Kantli GB, Nayaka S.	Antibiotics (Basel)	10.3390/antibiotics12071175	2023
Enzymology	The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.	Sun Y, Huang X, Osawa Y, Chen YE, Zhang H.	Molecules	10.3390/molecules28145353	2023
	The rate-limiting catalytic steps of hydroxymandelate synthase from Amycolatopsis orientalis.	He P, Conrad JA, Moran GR.	Biochemistry	10.1021/bi901674q	2010
Enzymology	Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation.	Yan Y, Wu J, Hu G, Gao C, Guo L, Chen X, Liu L, Song W.	Synth Syst Biotechnol	10.1016/j.synbio.2022.04.009	2022
	An aurora of natural products-based drug discovery is coming.	Tong Y, Deng Z.	Synth Syst Biotechnol	10.1016/j.synbio.2020.05.003	2020
Genetics	Revisiting the Taxonomic Status of the Biomedically and Industrially Important Genus Amycolatopsis, Using a Phylogenomic Approach.	Sangal V, Goodfellow M, Blom J, Tan GYA, Klenk HP, Sutcliffe IC.	Front Microbiol	10.3389/fmicb.2018.02281	2018
Metabolism	Intra- and extra-cellular flux distributions of TCA and glyoxalate cycle and vancomycin production of Amycolatopsis orieantalis grown in different glycerol concentration.	Ayar-Kayali H, Tarhan L.	Prikl Biokhim Mikrobiol	10.1134/s0003683810050029	2010
	Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi.	Tran PN, Yen MR, Chiang CY, Lin HC, Chen PY.	Appl Microbiol Biotechnol	10.1007/s00253-019-09708-z	2019
Metabolism	Optimization of culture conditions and scale-up to pilot and plant scales for vancomycin production by Amycolatopsis orientalis.	Jung HM, Kim SY, Moon HJ, Oh DK, Lee JK.	Appl Microbiol Biotechnol	10.1007/s00253-007-1221-4	2007
Enzymology	Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate.	Brownlee J, He P, Moran GR, Harrison DH.	Biochemistry	10.1021/bi701438r	2008
Enzymology	Genome mining in Amycolatopsis balhimycina for ferredoxins capable of supporting cytochrome P450 enzymes involved in glycopeptide antibiotic biosynthesis.	Geib N, Weber T, Wortz T, Zerbe K, Wohlleben W, Robinson JA.	FEMS Microbiol Lett	10.1111/j.1574-6968.2010.01933.x	2010
Metabolism	Cloning and expression of a cytochrome P450 hydroxylase gene from Amycolatopsis orientalis: hydroxylation of epothilone B for the production of epothilone F.	Basch J, Chiang SJ.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0173-5	2007
	Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population.	Wang CW, Lin WC, Chen WT, Chen CB, Lu CW, Hou HH, Hui RC, Wu J, Chang CJ, Chang YC, Chung WH, Taiwan Severe Cutaneous Adverse Reaction Consortium.	Front Pharmacol	10.3389/fphar.2022.954596	2022
Metabolism	Production of poly(L-lactide)-degrading enzyme by Amycolatopsis orientalis for biological recycling of poly(L-lactide).	Jarerat A, Tokiwa Y, Tanaka H.	Appl Microbiol Biotechnol	10.1007/s00253-006-0343-4	2006
Enzymology	Exo-beta-D-glucosaminidase from Amycolatopsis orientalis: catalytic residues, sugar recognition specificity, kinetics, and synergism.	Fukamizo T, Fleury A, Cote N, Mitsutomi M, Brzezinski R.	Glycobiology	10.1093/glycob/cwl026	2006
Metabolism	Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics.	Shi R, Lamb SS, Zakeri B, Proteau A, Cui Q, Sulea T, Matte A, Wright GD, Cygler M.	Chem Biol	10.1016/j.chembiol.2009.02.007	2009
Metabolism	Engineering enzymes for improved catalytic efficiency: a computational study of site mutagenesis in epothilone-B hydroxylase.	Nayeem A, Chiang SJ, Liu SW, Sun Y, You L, Basch J.	Protein Eng Des Sel	10.1093/protein/gzn081	2009
Metabolism	Balance between aerobic and anaerobic metabolites production of Amycolatopsis orientalis depending on initial glucose concentration.	Ayar-Kayali H, Tarhan L.	Prep Biochem Biotechnol	10.1080/10826060701386737	2007
	Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution.	Liu X, Li F, Sun T, Guo J, Zhang X, Zheng X, Du L, Zhang W, Ma L, Li S.	Commun Biol	10.1038/s42003-022-03764-4	2022
Metabolism	Oligosaccharide hydrolysis by chitosanase enzymes monitored by real-time electrospray ionization-mass spectrometry.	Dennhart N, Fukamizo T, Brzezinski R, Lacombe-Harvey ME, Letzel T.	J Biotechnol	10.1016/j.jbiotec.2008.02.004	2008
Enzymology	Purification and characterization of a chitinase from Amycolatopsis orientalis with N-acetyllactosamine-repeating unit releasing activity.	Murata T, Amarume S, Hattori T, Tokuyama S, Tokuyasu K, Kawagishi H, Usui T.	Biochem Biophys Res Commun	10.1016/j.bbrc.2005.08.123	2005
	Marker-Free Genome Engineering in Amycolatopsis Using the pSAM2 Site-Specific Recombination System.	Santos LDF, Caraty-Philippe L, Darbon E, Pernodet JL.	Microorganisms	10.3390/microorganisms10040828	2022
Metabolism	The structural basis of substrate recognition in an exo-beta-D-glucosaminidase involved in chitosan hydrolysis.	van Bueren AL, Ghinet MG, Gregg K, Fleury A, Brzezinski R, Boraston AB.	J Mol Biol	10.1016/j.jmb.2008.10.031	2009
Metabolism	Multi-integrated approach for unraveling small open reading frames potentially associated with secondary metabolism in Streptomyces.	Fan S-M, Li Z-Q, Zhang S-Z, Chen L-Y, Wei X-Y, Liang J, Zhao X-Q, Su C.	mSystems	10.1128/msystems.00245-23	2023
	Exploring the sequence-function space of microbial fucosidases.	Martinez Gascuena A, Wu H, Wang R, Owen CD, Hernando PJ, Monaco S, Penner M, Xing K, Le Gall G, Gardner R, Ndeh D, Urbanowicz PA, Spencer DIR, Walsh M, Angulo J, Juge N.	Commun Chem	10.1038/s42004-024-01212-4	2024
	Exploration of Amycolatopsis diversity in soil using genus-specific primers and novel selective media.	Tan GY, Ward AC, Goodfellow M.	Syst Appl Microbiol	10.1016/j.syapm.2006.01.007	2006
	GC-MS Based Characterization, Antibacterial, Antifungal and Anti-Oncogenic Activity of Ethyl Acetate Extract of Aspergillus niger Strain AK-6 Isolated from Rhizospheric Soil.	Niazi SK, Basavarajappa DS, Kumaraswamy SH, Bepari A, Hiremath H, Nagaraja SK, Rudrappa M, Hugar A, Cordero MAW, Nayaka S.	Curr Issues Mol Biol	10.3390/cimb45050241	2023
	Efficient Biocatalytic Preparation of Rebaudioside KA: Highly Selective Glycosylation Coupled with UDPG Regeneration.	Zhang Y, Xu S, Jin Y, Dai Y, Chen Y, Wu X.	Sci Rep	10.1038/s41598-020-63379-9	2020
	Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System.	Guffey AA, Loll PJ.	Microorganisms	10.3390/microorganisms9102026	2021
Metabolism	Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.	Mo X, Shi C, Gui C, Zhang Y, Ju J, Wang Q.	Microb Cell Fact	10.1186/s12934-017-0718-5	2017
	Genetic engineering approaches for the fermentative production of phenylglycines.	Moosmann D, Mokeev V, Kulik A, Osipenkov N, Kocadinc S, Ort-Winklbauer R, Handel F, Hennrich O, Youn JW, Sprenger GA, Mast Y.	Appl Microbiol Biotechnol	10.1007/s00253-020-10447-9	2020
Metabolism	Enzymatic synthesis of spacer-linked divalent glycosides carrying N-acetylglucosamine and N-acetyllactosamine: analysis of cross-linking activities with WGA.	Misawa Y, Akimoto T, Amarume S, Murata T, Usui T.	J Biochem	10.1093/jb/mvm200	2008
	Rational design of enzyme activity and enantioselectivity.	Song Z, Zhang Q, Wu W, Pu Z, Yu H.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1129149	2023
Biotechnology	An Overview of Microorganisms Immobilized in a Gel Structure for the Production of Precursors, Antibiotics, and Valuable Products.	Berillo D, Malika T, Baimakhanova BB, Sadanov AK, Berezin VE, Trenozhnikova LP, Baimakhanova GB, Amangeldi AA, Kerimzhanova B.	Gels	10.3390/gels10100646	2024
Metabolism	Optimization of fermentation conditions for production of glycopeptide antibiotic vancomycin by Amycolatopsis orientalis.	Padma PN, Rao AB, Yadav JS, Reddy G.	Appl Biochem Biotechnol	10.1385/abab:102-103:1-6:395	2002
Enzymology	Systematic Evaluation of Imine-Reducing Enzymes: Common Principles in Imine Reductases, beta-Hydroxy Acid Dehydrogenases, and Short-Chain Dehydrogenases/ Reductases.	Stockinger P, Roth S, Muller M, Pleiss J.	Chembiochem	10.1002/cbic.202000213	2020
Metabolism	Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.	Banskota AH, Mcalpine JB, Sorensen D, Ibrahim A, Aouidate M, Piraee M, Alarco AM, Farnet CM, Zazopoulos E.	J Antibiot (Tokyo)	10.1038/ja.2006.74	2006
Metabolism	Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg).	Muller U, van Assema F, Gunsior M, Orf S, Kremer S, Schipper D, Wagemans A, Townsend CA, Sonke T, Bovenberg R, Wubbolts M.	Metab Eng	10.1016/j.ymben.2005.12.001	2006
Genetics	Comparative genomics reveals insight into the phylogeny and habitat adaptation of novel Amycolatopsis species, an endophytic actinomycete associated with scab lesions on potato tubers.	Wannawong T, Mhuantong W, Macharoen P, Niemhom N, Sitdhipol J, Chaiyawan N, Umrung S, Tanasupawat S, Suwannarach N, Asami Y, Kuncharoen N.	Front Plant Sci	10.3389/fpls.2024.1346574	2024
	Engineering Escherichia coli for renewable benzyl alcohol production.	Pugh S, McKenna R, Halloum I, Nielsen DR.	Metab Eng Commun	10.1016/j.meteno.2015.06.002	2015
Metabolism	[Increase in eremomycin production by regeneration and UV-irradiation of Amycolatopsis orientalis subsp. eremomycini protoplasts].	Trenin AS, Fedorova GB, Laiko AV, Dudnik IuV.	Antibiot Khimioter		2001
	Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids.	Price CL, Warrilow AGS, Rolley NJ, Parker JE, Thoss V, Kelly DE, Corcionivoschi N, Kelly SL.	PLoS One	10.1371/journal.pone.0265227	2022
Enzymology	Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway.	Merkel AB, Temple GK, Burkart MD, Losey HC, Beis K, Walsh CT, Naismith JH.	Acta Crystallogr D Biol Crystallogr	10.1107/s0907444902007382	2002
	Combinatorial glycosylation of glycopeptide antibiotics.	Baltz RH.	Chem Biol	10.1016/s1074-5521(02)00289-2	2002
	Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects.	Kisil OV, Efimenko TA, Efremenkova OV.	Antibiotics (Basel)	10.3390/antibiotics10101254	2021
	Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete.	Hesketh A, Bucca G, Smith CP, Hong HJ.	Front Microbiol	10.3389/fmicb.2021.641756	2021
	Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci.	Muhlberg E, Umstatter F, Domhan C, Hertlein T, Ohlsen K, Krause A, Kleist C, Beijer B, Zimmermann S, Haberkorn U, Mier W, Uhl P.	Pharmaceuticals (Basel)	10.3390/ph13060110	2020
	The putative polyketide cyclase MSMEG_0129 from Mycobacterium smegmatis: purification, crystallization and X-ray crystallographic analysis.	Zheng S, Zhou Y, Fleming J, Zhou Y, Liu W, Bi L.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x17008937	2017
Enzymology	Screening, overexpression and characterization of an N-acylamino acid racemase from Amycolatopsis orientalis subsp. lurida.	Verseck S, Bommarius A, Kula MR.	Appl Microbiol Biotechnol	10.1007/s002530000508	2001
Metabolism	Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.	Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W.	BMC Genomics	10.1186/1471-2164-15-363	2014
Enzymology	Site-directed mutagenesis and protein 3D-homology modelling suggest a catalytic mechanism for UDP-glucose-dependent betanidin 5-O-glucosyltransferase from Dorotheanthus bellidiformis.	Hans J, Brandt W, Vogt T.	Plant J	10.1111/j.1365-313x.2004.02133.x	2004
	Physicochemical Stability of Vancomycin at High Concentrations in Polypropylene Syringes.	d'Huart E, Vigneron J, Charmillon A, Clarot I, Demore B.	Can J Hosp Pharm	10.4212/cjhp.v72i5.2929	2019
	Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.	McLean KJ, Hans M, Meijrink B, van Scheppingen WB, Vollebregt A, Tee KL, van der Laan JM, Leys D, Munro AW, van den Berg MA.	Proc Natl Acad Sci U S A	10.1073/pnas.1419028112	2015
	Crystallization and preliminary X-ray crystallographic analysis of recombinant beta-mannosidase from Aspergillus niger.	Demo G, Fliedrova B, Weignerova L, Wimmerova M.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309113002522	2013
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Enzymology	Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.	Lin KH, Lyu SY, Yeh HW, Li YS, Hsu NS, Huang CM, Wang YL, Shih HW, Wang ZC, Wu CJ, Li TL.	Protein Sci	10.1002/pro.3879	2020
	Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis.	Pylypenko O, Vitali F, Zerbe K, Robinson JA, Schlichting I.	J Biol Chem	10.1074/jbc.m306486200	2003
Biotechnology	Marine-Derived Actinomycetes: Biodegradation of Plastics and Formation of PHA Bioplastics-A Circular Bioeconomy Approach.	Oliveira J, Almeida PL, Sobral RG, Lourenco ND, Gaudencio SP.	Mar Drugs	10.3390/md20120760	2022
Enzymology	Isolation and characterization of actinomycetes from Brazilian tropical soils.	Semedo LT, Linhares AA, Gomes RC, Manfio GP, Alviano CS, Linhares LF, Coelho RR.	Microbiol Res	10.1016/s0944-5013(01)80007-0	2001
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Genetics	Chromosome topology and genome size of selected actinomycetes species.	Redenbach M, Scheel J, Schmidt U.	Antonie Van Leeuwenhoek	10.1023/a:1010289326752	2000
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	Chemometrics and genome mining reveal an unprecedented family of sugar acid-containing fungal nonribosomal cyclodepsipeptides.	Wang C, Xiao D, Dun B, Yin M, Tsega AS, Xie L, Li W, Yue Q, Wang S, Gao H, Lin M, Zhang L, Molnar I, Xu Y.	Proc Natl Acad Sci U S A	10.1073/pnas.2123379119	2022
Pathogenicity	Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms.	Patel R.	FEMS Microbiol Lett	10.1111/j.1574-6968.2000.tb09032.x	2000
Genetics	A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus.	Tang B, Xie F, Zhao W, Wang J, Dai S, Zheng H, Ding X, Cen X, Liu H, Yu Y, Zhou H, Zhou Y, Zhang L, Goodfellow M, Zhao GP.	Synth Syst Biotechnol	10.1016/j.synbio.2016.05.001	2016
	Plant cell wall architecture guided design of CBM3-GH11 chimeras with enhanced xylanase activity using a tandem repeat left-handed beta-3-prism scaffold.	Pinheiro MP, Reis RAG, Dupree P, Ward RJ.	Comput Struct Biotechnol J	10.1016/j.csbj.2021.01.011	2021
Metabolism	Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.	Yeh HW, Lin KH, Lyu SY, Li YS, Huang CM, Wang YL, Shih HW, Hsu NS, Wu CJ, Li TL.	Acta Crystallogr D Struct Biol	10.1107/s2059798319009574	2019
	Production of a Novel Tetrahydroxynaphthalene (THN) Derivative from Nocardia sp. CS682 by Metabolic Engineering and Its Bioactivities.	Mishra R, Dhakal D, Han JM, Lim HN, Jung HJ, Yamaguchi T, Sohng JK.	Molecules	10.3390/molecules24020244	2019
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Metabolism	Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.	Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT.	Biochemistry	10.1021/bi010050w	2001
Enzymology	Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.	Hubbard BK, Thomas MG, Walsh CT.	Chem Biol	10.1016/s1074-5521(00)00043-0	2000
	Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol.	Zarogoulidis P, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Spyratos D, Pitsiou G, Petridis D, Pataka A, Huang H, Li Q, Yarmus L, Hohenforst-Schmidt W, Pezirkianidis N, Zarogoulidis K.	Drug Des Devel Ther	10.2147/dddt.s66576	2014
Metabolism	Streptomyces Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability.	Jones SE, Pham CA, Zambri MP, McKillip J, Carlson EE, Elliot MA.	mBio	10.1128/mbio.00171-19	2019
Metabolism	A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.	Sasaki E, Ogasawara Y, Liu HW.	J Am Chem Soc	10.1021/ja1014037	2010
Metabolism	New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.	Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A.	Chembiochem	10.1002/cbic.201700428	2018
Metabolism	Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose-xylose mixture.	Li FF, Zhao Y, Li BZ, Qiao JJ, Zhao GR.	Microb Cell Fact	10.1186/s12934-016-0489-4	2016
	Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds.	Caruso DJ, Palombo EA, Moulton SE, Zaferanloo B.	Microorganisms	10.3390/microorganisms10101990	2022
	Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds-Present and Future Strain Construction Strategies.	Averesch NJH, Kromer JO.	Front Bioeng Biotechnol	10.3389/fbioe.2018.00032	2018
	Mining of efficient microbial UDP-glycosyltransferases by motif evolution cross plant kingdom for application in biosynthesis of salidroside.	Fan B, Chen T, Zhang S, Wu B, He B.	Sci Rep	10.1038/s41598-017-00568-z	2017
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	Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics.	Lu J, Long Q, Zhao Z, Chen L, He W, Hong J, Liu K, Wang Y, Pang X, Deng Z, Tao M.	Front Microbiol	10.3389/fmicb.2020.593217	2020
Genetics	The bone-degrading enzyme machinery: From multi-component understanding to the treatment of residues from the meat industry.	Fernandez-Lopez L, Sanchez-Carrillo S, Garcia-Moyano A, Borchert E, Almendral D, Alonso S, Cea-Rama I, Miguez N, Larsen O, Werner J, Makarova KS, Plou FJ, Dahlgren TG, Sanz-Aparicio J, Hentschel U, Bjerga GEK, Ferrer M.	Comput Struct Biotechnol J	10.1016/j.csbj.2021.11.027	2021
Metabolism	A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins.	Sauber K, Aretz W, Meiwes J, Wollmann T.	Enzyme Microb Technol	10.1016/0141-0229(95)00171-9	1996
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	Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.	van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.	Chem Biol	10.1016/s1074-5521(98)90060-6	1998
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Metabolism	MM 47761 and MM 49721, glycopeptide antibiotics produced by a new strain of Amycolatopsis orientalis. Isolation, purification and structure determination.	Box SJ, Elson AL, Gilpin ML, Winstanley DJ.	J Antibiot (Tokyo)	10.7164/antibiotics.43.931	1990
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Metabolism	Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis.	Solenberg PJ, Matsushima P, Stack DR, Wilkie SC, Thompson RC, Baltz RH.	Chem Biol	10.1016/s1074-5521(97)90288-x	1997
	Application of Chitinous Materials in Production and Purification of a Poly(l-lactic acid) Depolymerase from Pseudomonas tamsuii TKU015.	Liang TW, Jen SN, Nguyen AD, Wang SL.	Polymers (Basel)	10.3390/polym8030098	2016
Enzymology	Crystallization and preliminary X-ray crystallographic studies of an exo-beta-D-glucosaminidase from Trichoderma reesei.	Sakamoto Y, Ike M, Tanaka N, Suzuki Y, Ogasawara W, Okada H, Nonaka T, Morikawa Y, Nakamura KT.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309110000606	2010
	Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques.	Petrickova K, Petrickova K, Chronakova A, Zelenka T, Chrudimsky T, Pospisil S, Petricek M, Kristufek V.	Front Microbiol	10.3389/fmicb.2015.00814	2015
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	Taxonomy and Broad-Spectrum Antifungal Activity of Streptomyces sp. SCA3-4 Isolated From Rhizosphere Soil of Opuntia stricta.	Qi D, Zou L, Zhou D, Chen Y, Gao Z, Feng R, Zhang M, Li K, Xie J, Wang W.	Front Microbiol	10.3389/fmicb.2019.01390	2019
Metabolism	Chitinolytic functions in actinobacteria: ecology, enzymes, and evolution.	Lacombe-Harvey ME, Brzezinski R, Beaulieu C.	Appl Microbiol Biotechnol	10.1007/s00253-018-9149-4	2018
Pathogenicity	Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance.	Piepenbreier H, Diehl A, Fritz G.	Nat Commun	10.1038/s41467-019-10673-4	2019
	Cyclic Peptides in Pipeline: What Future for These Great Molecules?	Costa L, Sousa E, Fernandes C.	Pharmaceuticals (Basel)	10.3390/ph16070996	2023
	Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection.	Ferry T, Kolenda C, Briot T, Souche A, Lustig S, Josse J, Batailler C, Pirot F, Medina M, Leboucher G, Laurent F, On Behalf Of The Lyon Bji Study Group, On Behalf Of The PHAGEinLYON Study Group.	Viruses	10.3390/v13122414	2021
	From Worms to Drug Candidate: The Story of Odilorhabdins, a New Class of Antimicrobial Agents.	Racine E, Gualtieri M.	Front Microbiol	10.3389/fmicb.2019.02893	2019
	Lactobacillus reuteri and Escherichia coli in the human gut microbiota may predict weight gain associated with vancomycin treatment.	Million M, Thuny F, Angelakis E, Casalta JP, Giorgi R, Habib G, Raoult D.	Nutr Diabetes	10.1038/nutd.2013.28	2013
	A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes.	Thanapipatsiri A, Claesen J, Gomez-Escribano JP, Bibb M, Thamchaipenet A.	Microb Cell Fact	10.1186/s12934-015-0335-0	2015
Pathogenicity	A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.	Antonoplis A, Zang X, Huttner MA, Chong KKL, Lee YB, Co JY, Amieva MR, Kline KA, Wender PA, Cegelski L.	J Am Chem Soc	10.1021/jacs.8b08711	2018
Metabolism	Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid.	Sun Z, Ning Y, Liu L, Liu Y, Sun B, Jiang W, Yang C, Yang S.	Microb Cell Fact	10.1186/1475-2859-10-71	2011
Metabolism	UK-69,753, a novel member of the efrotomycin family of antibiotics. I. Taxonomy of the producing organism, fermentation and isolation.	Pacey MS, Jefson MR, Huang LH, Cullen WP, Maeda H, Tone J, Nishiyama S, Kaneda K, Ishiguro M.	J Antibiot (Tokyo)	10.7164/antibiotics.42.1453	1989
Metabolism	DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity.	Marshall CG, Wright GD.	J Bacteriol	10.1128/jb.180.21.5792-5795.1998	1998
	Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters.	Kumar A, Sorensen JL, Hansen FT, Arvas M, Syed MF, Hassan L, Benz JP, Record E, Henrissat B, Poggeler S, Kempken F.	Sci Rep	10.1038/s41598-018-28473-z	2018
Metabolism	The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli.	Cote JM, Ramirez-Mondragon CA, Siegel ZS, Czyzyk DJ, Gao J, Sham YY, Mukerji I, Taylor EA.	Biochemistry	10.1021/acs.biochem.6b00850	2017
Enzymology	Comparison of six generic vancomycin products for treatment of methicillin-resistant Staphylococcus aureus experimental endocarditis in rabbits.	Tattevin P, Saleh-Mghir A, Davido B, Ghout I, Massias L, Garcia de la Maria C, Miro JM, Perronne C, Laurent F, Cremieux AC.	Antimicrob Agents Chemother	10.1128/aac.01669-12	2013
Metabolism	TxtH is a key component of the thaxtomin biosynthetic machinery in the potato common scab pathogen Streptomyces scabies.	Li Y, Liu J, Adekunle D, Bown L, Tahlan K, Bignell DRD.	Mol Plant Pathol	10.1111/mpp.12843	2019
	A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens.	Terra L, Dyson PJ, Hitchings MD, Thomas L, Abdelhameed A, Banat IM, Gazze SA, Vujaklija D, Facey PD, Francis LW, Quinn GA.	Front Microbiol	10.3389/fmicb.2018.02458	2018
Metabolism	Modular glucuronoxylan-specific xylanase with a family CBM35 carbohydrate-binding module.	Valenzuela SV, Diaz P, Pastor FI.	Appl Environ Microbiol	10.1128/aem.07932-11	2012
	Antimicrobial resistance gene delivery in animal feeds.	Lu K, Asano R, Davies J.	Emerg Infect Dis	10.3201/eid1004.030506	2004
	Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle.	Zhgun AA.	Int J Mol Sci	10.3390/ijms241311184	2023
Pathogenicity	Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.	Thaker MN, Wright GD.	ACS Synth Biol	10.1021/sb300092n	2015
	D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.	Marshall CG, Broadhead G, Leskiw BK, Wright GD.	Proc Natl Acad Sci U S A	10.1073/pnas.94.12.6480	1997
	Direct replacement of antibodies with molecularly imprinted polymer nanoparticles in ELISA--development of a novel assay for vancomycin.	Chianella I, Guerreiro A, Moczko E, Caygill JS, Piletska EV, De Vargas Sansalvador IM, Whitcombe MJ, Piletsky SA.	Anal Chem	10.1021/ac402102j	2013
Pathogenicity	Short-Chain Chitin Oligomers: Promoters of Plant Growth.	Winkler AJ, Dominguez-Nunez JA, Aranaz I, Poza-Carrion C, Ramonell K, Somerville S, Berrocal-Lobo M.	Mar Drugs	10.3390/md15020040	2017
	The Interaction of Hydroxymandelate Synthase with the 4-Hydroxyphenylpyruvate Dioxygenase Inhibitor: NTBC.	Conrad JA, Moran GR.	Inorganica Chim Acta	10.1016/j.ica.2007.07.036	2008
Enzymology	The Structure of an Archaeal beta-Glucosaminidase Provides Insight into Glycoside Hydrolase Evolution.	Mine S, Watanabe M, Kamachi S, Abe Y, Ueda T.	J Biol Chem	10.1074/jbc.m116.766535	2017
Biotechnology	Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers.	Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Swainston N, Spiess R, Taylor S, Mulherin P, Parker S, Rowe W, Matthews NE, Malone KJ, Le Feuvre R, Shapira P, Barran P, Turner NJ, Micklefield J, Breitling R, Takano E, Scrutton NS.	Metab Eng	10.1016/j.ymben.2020.04.008	2020
	Controlled Delivery of Vancomycin via Charged Hydrogels.	Gustafson CT, Boakye-Agyeman F, Brinkman CL, Reid JM, Patel R, Bajzer Z, Dadsetan M, Yaszemski MJ.	PLoS One	10.1371/journal.pone.0146401	2016
	Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays.	Hadwiger ME, Sommers CD, Mans DJ, Patel V, Boyne MT.	Antimicrob Agents Chemother	10.1128/aac.00164-12	2012
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Enzymology	The role of Ile87 of CYP158A2 in oxidative coupling reaction.	Zhao B, Bellamine A, Lei L, Waterman MR.	Arch Biochem Biophys	10.1016/j.abb.2011.12.007	2012
Pathogenicity	Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect.	Santos-Beneit F.	BMC Genomics	10.1186/s12864-018-4838-z	2018
	mMass as a software tool for the annotation of cyclic peptide tandem mass spectra.	Niedermeyer TH, Strohalm M.	PLoS One	10.1371/journal.pone.0044913	2012
	Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.	Marshall CG, Lessard IA, Park I, Wright GD.	Antimicrob Agents Chemother	10.1128/aac.42.9.2215	1998
Metabolism	Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes.	Spanogiannopoulos P, Thaker M, Koteva K, Waglechner N, Wright GD.	Antimicrob Agents Chemother	10.1128/aac.01166-12	2012
Metabolism	Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis.	Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW.	Nature	10.1038/nature13256	2014
Pathogenicity	Mechanism of intrinsic resistance to vancomycin in Clostridium innocuum NCIB 10674.	David V, Bozdogan B, Mainardi JL, Legrand R, Gutmann L, Leclercq R.	J Bacteriol	10.1128/jb.186.11.3415-3422.2004	2004
Metabolism	Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.	Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH.	J Am Chem Soc	10.1021/ja2112228	2012
Pathogenicity	Nanomaterial-based sensors for detection of foodborne bacterial pathogens and toxins as well as pork adulteration in meat products.	Inbaraj BS, Chen BH.	J Food Drug Anal	10.1016/j.jfda.2015.05.001	2016
Pathogenicity	Understanding tolerance to cell wall-active antibiotics.	Dorr T.	Ann N Y Acad Sci	10.1111/nyas.14541	2021
Pathogenicity	In vitro activity of LY264826, a new glycopeptide antibiotic, against gram-positive bacteria isolated from patients with cancer.	Rolston KV, Nguyen H, Messer M.	Antimicrob Agents Chemother	10.1128/aac.34.11.2137	1990
Pathogenicity	Molecular mechanisms of vancomycin resistance.	Stogios PJ, Savchenko A.	Protein Sci	10.1002/pro.3819	2020
Metabolism	A diverse range of bacterial and eukaryotic chitinases hydrolyzes the LacNAc (Galbeta1-4GlcNAc) and LacdiNAc (GalNAcbeta1-4GlcNAc) motifs found on vertebrate and insect cells.	Frederiksen RF, Yoshimura Y, Storgaard BG, Paspaliari DK, Petersen BO, Chen K, Larsen T, Duus JO, Ingmer H, Bovin NV, Westerlind U, Blixt O, Palcic MM, Leisner JJ.	J Biol Chem	10.1074/jbc.m114.607291	2015
Metabolism	Probing the catalytic mechanism of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.	Bruender NA, Holden HM.	Protein Sci	10.1002/pro.2074	2012
Metabolism	Cloning, sequencing, and functional analysis of an iterative type I polyketide synthase gene cluster for biosynthesis of the antitumor chlorinated polyenone neocarzilin in "Streptomyces carzinostaticus".	Otsuka M, Ichinose K, Fujii I, Ebizuka Y.	Antimicrob Agents Chemother	10.1128/aac.48.9.3468-3476.2004	2004
Enzymology	Two exo-beta-D-glucosaminidases/exochitosanases from actinomycetes define a new subfamily within family 2 of glycoside hydrolases.	Cote N, Fleury A, Dumont-Blanchette E, Fukamizo T, Mitsutomi M, Brzezinski R.	Biochem J	10.1042/bj20051436	2006
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Enzymology	Structural elucidation of the cyclization mechanism of alpha-1,6-glucan by Bacillus circulans T-3040 cycloisomaltooligosaccharide glucanotransferase.	Suzuki N, Fujimoto Z, Kim YM, Momma M, Kishine N, Suzuki R, Suzuki S, Kitamura S, Kobayashi M, Kimura A, Funane K.	J Biol Chem	10.1074/jbc.m114.547992	2014
Metabolism	TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.	Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H.	Appl Environ Microbiol	10.1128/aem.03083-09	2010
	Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.	Hakvag S, Fjaervik E, Josefsen KD, Ian E, Ellingsen TE, Zotchev SB.	Mar Drugs	10.3390/md6040620	2008
Metabolism	Methods to optimize myxobacterial fermentations using off-gas analysis.	Huttel S, Muller R.	Microb Cell Fact	10.1186/1475-2859-11-59	2012
	A Review of the Microbial Production of Bioactive Natural Products and Biologics.	Pham JV, Yilma MA, Feliz A, Majid MT, Maffetone N, Walker JR, Kim E, Cho HJ, Reynolds JM, Song MC, Park SR, Yoon YJ.	Front Microbiol	10.3389/fmicb.2019.01404	2019
Enzymology	The first identification of carbohydrate binding modules specific to chitosan.	Shinya S, Ohnuma T, Yamashiro R, Kimoto H, Kusaoke H, Anbazhagan P, Juffer AH, Fukamizo T.	J Biol Chem	10.1074/jbc.m113.503243	2013
Enzymology	Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P.	Ye S, Molloy B, Brana AF, Zabala D, Olano C, Cortes J, Moris F, Salas JA, Mendez C.	Front Microbiol	10.3389/fmicb.2017.00194	2017
Pathogenicity	Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.	Marcone GL, Binda E, Carrano L, Bibb M, Marinelli F.	Antimicrob Agents Chemother	10.1128/aac.02626-14	2014
Metabolism	Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways.	Shao Z, Blodgett JA, Circello BT, Eliot AC, Woodyer R, Li G, van der Donk WA, Metcalf WW, Zhao H.	J Biol Chem	10.1074/jbc.m801788200	2008
Metabolism	Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius.	Anjum RS, Bray SM, Blackwood JK, Kilkenny ML, Coelho MA, Foster BM, Li S, Howard JA, Pellegrini L, Albers SV, Deery MJ, Robinson NP.	Nat Commun	10.1038/ncomms9163	2015
Metabolism	Chiral hydroxylation at the mononuclear nonheme Fe(II) center of 4-(S) hydroxymandelate synthase--a structure-activity relationship analysis.	Di Giuro CM, Konstantinovics C, Rinner U, Nowikow C, Leitner E, Straganz GD.	PLoS One	10.1371/journal.pone.0068932	2013
	Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations.	Damjanovic J, Miao J, Huang H, Lin YS.	Chem Rev	10.1021/acs.chemrev.0c01087	2021
Genetics	Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureus.	Hu Q, Peng H, Rao X.	Front Microbiol	10.3389/fmicb.2016.01601	2016
Metabolism	Actinoplanes teichomyceticus ATCC 31121 as a cell factory for producing teicoplanin.	Taurino C, Frattini L, Marcone GL, Gastaldo L, Marinelli F.	Microb Cell Fact	10.1186/1475-2859-10-82	2011
Metabolism	Interspecies modulation of bacterial development through iron competition and siderophore piracy.	Traxler MF, Seyedsayamdost MR, Clardy J, Kolter R.	Mol Microbiol	10.1111/mmi.12008	2012
Metabolism	Mining the metabiome: identifying novel natural products from microbial communities.	Milshteyn A, Schneider JS, Brady SF.	Chem Biol	10.1016/j.chembiol.2014.08.006	2014
Metabolism	Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.	Gallo G, Alduina R, Renzone G, Thykaer J, Bianco L, Eliasson-Lantz A, Scaloni A, Puglia AM.	Microb Cell Fact	10.1186/1475-2859-9-95	2010
Enzymology	VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?	Lessard IA, Walsh CT.	Proc Natl Acad Sci U S A	10.1073/pnas.96.20.11028	1999
Enzymology	Halogenase genes in nonribosomal peptide synthetase gene clusters of Microcystis (cyanobacteria): sporadic distribution and evolution.	Cadel-Six S, Dauga C, Castets AM, Rippka R, Bouchier C, Tandeau de Marsac N, Welker M.	Mol Biol Evol	10.1093/molbev/msn150	2008
Pathogenicity	Antimicrobial Resistance in Enterococcus spp. of animal origin.	Torres C, Alonso CA, Ruiz-Ripa L, Leon-Sampedro R, Del Campo R, Coque TM.	Microbiol Spectr	10.1128/microbiolspec.arba-0032-2018	2018
Metabolism	Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.	Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD.	Proc Natl Acad Sci U S A	10.1073/pnas.102285099	2002
	Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis.	Zhang C, Bitto E, Goff RD, Singh S, Bingman CA, Griffith BR, Albermann C, Phillips GN, Thorson JS.	Chem Biol	10.1016/j.chembiol.2008.06.011	2008
Enzymology	Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium.	Belcher J, McLean KJ, Matthews S, Woodward LS, Fisher K, Rigby SEJ, Nelson DR, Potts D, Baynham MT, Parker DA, Leys D, Munro AW.	J Biol Chem	10.1074/jbc.m113.527325	2014
Metabolism	Structural characterization of OxyD, a cytochrome P450 involved in beta-hydroxytyrosine formation in vancomycin biosynthesis.	Cryle MJ, Meinhart A, Schlichting I.	J Biol Chem	10.1074/jbc.m110.131904	2010
Enzymology	Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis .	Vey JL, Al-Mestarihi A, Hu Y, Funk MA, Bachmann BO, Iverson TM.	Biochemistry	10.1021/bi101336u	2010
Metabolism	The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.	Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR.	J Bacteriol	10.1128/jb.180.9.2379-2386.1998	1998
Pathogenicity	Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markers.	Scherl A, Francois P, Charbonnier Y, Deshusses JM, Koessler T, Huyghe A, Bento M, Stahl-Zeng J, Fischer A, Masselot A, Vaezzadeh A, Galle F, Renzoni A, Vaudaux P, Lew D, Zimmermann-Ivol CG, Binz PA, Sanchez JC, Hochstrasser DF, Schrenzel J.	BMC Genomics	10.1186/1471-2164-7-296	2006
Metabolism	Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.	Zhang H, White-Phillip JA, Melancon CE, Kwon HJ, Yu WL, Liu HW.	J Am Chem Soc	10.1021/ja0744854	2007
Enzymology	A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica.	Hilbert F, Garcia-del Portillo F, Groisman EA.	J Bacteriol	10.1128/jb.181.7.2158-2165.1999	1999
	Exploring the sequence-structure protein landscape in the glycosyltransferase family.	Zhang Z, Kochhar S, Grigorov M.	Protein Sci	10.1110/ps.03131303	2003
Metabolism	Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system.	Ryding NJ, Anderson TB, Champness WC.	J Bacteriol	10.1128/jb.184.3.794-805.2002	2002
Enzymology	Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.	Melancon CE, Hong L, White JA, Liu YN, Liu HW.	Biochemistry	10.1021/bi061907y	2007
	Application of spectroscopic methods for structural analysis of chitin and chitosan.	Kumirska J, Czerwicka M, Kaczynski Z, Bychowska A, Brzozowski K, Thoming J, Stepnowski P.	Mar Drugs	10.3390/md8051567	2010
Metabolism	P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.	Syed K, Yadav JS.	Crit Rev Microbiol	10.3109/1040841x.2012.682050	2012
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Pathogenicity	Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications.	Howden BP, Davies JK, Johnson PD, Stinear TP, Grayson ML.	Clin Microbiol Rev	10.1128/cmr.00042-09	2010
	Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis.	Gericke N, Beqaj D, Kronenberger T, Kulik A, Gavriilidou A, Franz-Wachtel M, Schoppmeier U, Harbig T, Rapp J, Grin I, Ziemert N, Link H, Nieselt K, Macek B, Wohlleben W, Stegmann E, Wagner S.	iScience	10.1016/j.isci.2025.112135	2025
Genetics	Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48.	Li X, Zhang C, Zhao Y, Lei X, Jiang Z, Zhang X, Zheng Z, Si S, Wang L, Hong B.	Microb Cell Fact	10.1186/s12934-021-01521-6	2021
Biotechnology	Lytic polysaccharide monooxygenase synergized with lignin-degrading enzymes for efficient lignin degradation.	Sun S, Li F, Li M, Zhang W, Jiang Z, Zhao H, Pu Y, Ragauskas AJ, Dai SY, Zhang X, Yu H, Yuan JS, Xie S.	iScience	10.1016/j.isci.2023.107870	2023
	Rapid physiological characterization of microorganisms by biosensor technique.	Riedel K, Kunze G.	Microbiol Res	10.1016/s0944-5013(97)80033-x	1997
Metabolism	Degradation of carbonyl sulfide by Actinomycetes and detection of clade D of beta-class carbonic anhydrase.	Ogawa T, Kato H, Higashide M, Nishimiya M, Katayama Y	FEMS Microbiol Lett	10.1093/femsle/fnw223	2016
Genetics	Genome Sequence of the Vancomycin-Producing Amycolatopsis orientalis subsp. orientalis Strain KCTC 9412T.	Jeong H, Sim YM, Kim HJ, Lee DW, Lim SK, Lee SJ	Genome Announc	10.1128/genomeA.00408-13	2013
Genetics	Nucleotide sequence of plasmid pA387 of Amycolatopsis benzoatilytica and construction of a conjugative shuttle vector.	Malhotra S, Majumdar S, Kumar M, Bhasin VK, Gartemann KH, Lal R	J Basic Microbiol	10.1002/jobm.200700326	2008
	The Vancomycin biosynthetic pathway is induced in oxygen-limited Amycolatopsis orientalis (ATCC 19795) cultures that do not produce antibiotic.	Dunstan GH, Avignone-Rossa C, Langley D, Bushell ME	Enzyme Microb Technol	10.1016/s0141-0229(00)00238-6	2000
Biotechnology	Vancomycin production is enhanced in chemostat culture with biomass-recycle.	McIntyre JJ, Bunch AW, Bull AT	Biotechnol Bioeng	10.1002/(sici)1097-0290(19990305)62:5<576::aid-bit9>3.0.co;2-p	1999
Biotechnology	Vancomycin production in batch and continuous culture.	McIntyre JJ, Bull AT, Bunch AW	Biotechnol Bioeng	10.1002/(SICI)1097-0290(19960220)49:4<412::AID-BIT8>3.0.CO;2-S	1996
Metabolism	Microbial de-mannosylation and mannosylation of teicoplanin derivatives.	Borghi A, Ferrari P, Gallo GG, Zanol M, Zerilli LF, Lancini GC	J Antibiot (Tokyo)	10.7164/antibiotics.44.1444	1991
Enzymology	Purification and characterization of an exo-beta-D-glucosaminidase, a novel type of enzyme, from Nocardia orientalis.	Nanjo F, Katsumi R, Sakai K	J Biol Chem	S0021-9258(19)38783-6	1990
Enzymology	Transglycosylation reaction of a chitinase purified from Nocardia orientalis.	Usui T, Hayashi Y, Nanjo F, Sakai K, Ishido Y	Biochim Biophys Acta	10.1016/0304-4165(87)90017-1	1987
Genetics	Amycolatopsis aidingensis sp. nov., a Halotolerant Actinobacterium, Produces New Secondary Metabolites.	Li R, Wang M, Ren Z, Ji Y, Yin M, Zhou H, Tang SK.	Front Microbiol	10.3389/fmicb.2021.743116	2021
	Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus.	Zakalyukina YV, Osterman IA, Wolf J, Neumann-Schaal M, Nouioui I, Biryukov MV.	Antonie Van Leeuwenhoek	10.1007/s10482-022-01716-w	2022
Metabolism	Amycolatopsis regifaucium sp. nov., a novel actinomycete that produces kigamicins.	Tan GYA, Robinson S, Lacey E, Brown R, Kim W, Goodfellow M.	Int J Syst Evol Microbiol	10.1099/ijs.0.64974-0	2007
Phylogeny	Amycolatopsis minnesotensis sp. nov., isolated from a prairie soil.	Lee SD, Kinkel LL, Samac DA.	Int J Syst Evol Microbiol	10.1099/ijs.0.63907-0	2006
Phylogeny	Amycolatopsis decaplanina sp. nov., a novel member of the genus with unusual morphology.	Wink J, Gandhi J, Kroppenstedt RM, Seibert G, Straubler B, Schumann P, Stackebrandt E.	Int J Syst Evol Microbiol	10.1099/ijs.0.02586-0	2004
Phylogeny	Sutterella faecalis sp. nov., isolated from human faeces.	Oh BS, Kim JS, Yu SY, Ryu SW, Park SH, Kang SW, Park JE, Choi SH, Han KI, Lee KC, Eom MK, Suh MK, Kim HS, Lee DH, Yoon H, Kim BY, Lee JH, Lee JS, Lee JH.	J Microbiol	10.1007/s12275-020-9396-9	2020
Phylogeny	Micromonospora soli sp. nov., isolated from rice rhizosphere soil.	Thawai C, Kittiwongwattana C, Thanaboripat D, Laosinwattana C, Koohakan P, Parinthawong N.	Antonie Van Leeuwenhoek	10.1007/s10482-016-0651-3	2016
Phylogeny	Micromonospora kangleipakensis sp. nov., isolated from a sample of limestone quarry.	Nimaichand S, Zhang YG, Cheng J, Li L, Zhang DF, Zhou EM, Dong L, Ningthoujam DS, Li WJ.	Int J Syst Evol Microbiol	10.1099/ijs.0.052746-0	2013
Phylogeny	Reclassification of Amycolatopsis orientalis DSM 43387 as Amycolatopsis benzoatilytica sp. nov.	Majumdar S, Prabhagaran SR, Shivaji S, Lal R	Int J Syst Evol Microbiol	10.1099/ijs.0.63766-0	2006
Phylogeny	Reclassification of Amycolatopsis orientalis subsp. lurida Lechevalier et al. 1986 as Amycolatopsis lurida sp. nov., comb. nov.	Stackebrandt E, Kroppenstedt RM, Wink J, Schumann P	Int J Syst Evol Microbiol	10.1099/ijs.0.02937-0	2004