Streptococcus pneumoniae DSM 14377 is a microaerophile, mesophilic, Gram-positive human pathogen of the family Streptococcaceae.
Gram-positive coccus-shaped microaerophile mesophilic human pathogen genome sequence 16S sequence| @ref 20215 |
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Last LPSN update
2026-02-09 11:21:30 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Lactobacillales |
| Family Streptococcaceae |
| Genus Streptococcus |
| Species Streptococcus pneumoniae |
| Full scientific name Streptococcus pneumoniae (Klein 1884) Chester 1901 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 5327 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive  | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 5327 | TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) | Medium recipe at MediaDive | Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water | ||
| 35161 | MEDIUM 6 - Columbia agar with 10 % horse blood | Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml) | |||
| 121896 | CIP Medium 6 | Medium recipe at CIP |
| @ref | Salt | Growth | Tested relation | Concentration | |
|---|---|---|---|---|---|
| 121896 | NaCl | growth | 6.5 % |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68381 | 40585 ChEBI | alpha-cyclodextrin | - | builds acid from | from API rID32STR |
| 68371 | 27613 ChEBI | amygdalin | - | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68381 | 29016 ChEBI | arginine | - | hydrolysis | from API rID32STR |
| 68371 | 17057 ChEBI | cellobiose | + | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68381 | 18333 ChEBI | D-arabitol | - | builds acid from | from API rID32STR |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | + | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | + | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68381 | 16899 ChEBI | D-mannitol | - | builds acid from | from API rID32STR |
| 68371 | 16024 ChEBI | D-mannose | + | builds acid from | from API 50CH acid |
| 68381 | 16988 ChEBI | D-ribose | - | builds acid from | from API rID32STR |
| 68371 | 16988 ChEBI | D-ribose | - | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68381 | 16443 ChEBI | D-tagatose | - | builds acid from | from API rID32STR |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 121896 | 4853 ChEBI | esculin | - | hydrolysis | |
| 68371 | 4853 ChEBI | esculin | - | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | - | builds acid from | from API 50CH acid |
| 68381 | 28087 ChEBI | glycogen | - | builds acid from | from API rID32STR |
| 68371 | 28087 ChEBI | glycogen | + | builds acid from | from API 50CH acid |
| 68381 | 606565 ChEBI | hippurate | - | hydrolysis | from API rID32STR |
| 121896 | 606565 ChEBI | hippurate | - | hydrolysis | |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 50CH acid |
| 68381 | 30849 ChEBI | L-arabinose | - | builds acid from | from API rID32STR |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68381 | 17716 ChEBI | lactose | + | builds acid from | from API rID32STR |
| 68371 | 17716 ChEBI | lactose | + | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | + | builds acid from | from API 50CH acid |
| 68381 | 17306 ChEBI | maltose | + | builds acid from | from API rID32STR |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68381 | 6731 ChEBI | melezitose | - | builds acid from | from API rID32STR |
| 68371 | 28053 ChEBI | melibiose | + | builds acid from | from API 50CH acid |
| 68381 | 28053 ChEBI | melibiose | - | builds acid from | from API rID32STR |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | + | builds acid from | from API 50CH acid |
| 121896 | 17632 ChEBI | nitrate | - | reduction | |
| 121896 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68381 | 16634 ChEBI | raffinose | + | builds acid from | from API rID32STR |
| 68371 | 16634 ChEBI | raffinose | + | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | + | builds acid from | from API 50CH acid |
| 68381 | 30911 ChEBI | sorbitol | - | builds acid from | from API rID32STR |
| 68371 | 28017 ChEBI | starch | + | builds acid from | from API 50CH acid |
| 68381 | 17992 ChEBI | sucrose | + | builds acid from | from API rID32STR |
| 68371 | 17992 ChEBI | sucrose | + | builds acid from | from API 50CH acid |
| 68371 | 27082 ChEBI | trehalose | + | builds acid from | from API 50CH acid |
| 68381 | 27082 ChEBI | trehalose | + | builds acid from | from API rID32STR |
| 68371 | 32528 ChEBI | turanose | + | builds acid from | from API 50CH acid |
| 68381 | 16199 ChEBI | urea | - | hydrolysis | from API rID32STR |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | ChEBI | Metabolite | Is sensitive | Is resistant | |
|---|---|---|---|---|---|
| 121896 | 86455 | optochin |
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68381 | 15688 ChEBI | acetoin | from API rID32STR |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | - | 3.1.3.2 | from API zym |
| 68381 | Alanyl-Phenylalanyl-Proline arylamidase | + | from API rID32STR | |
| 121896 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68381 | alkaline phosphatase | - | 3.1.3.1 | from API rID32STR |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | + | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68381 | arginine dihydrolase | - | 3.5.3.6 | from API rID32STR |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 121896 | beta-galactosidase | + | 3.2.1.23 | |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68381 | beta-glucuronidase | - | 3.2.1.31 | from API rID32STR |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 68381 | beta-mannosidase | - | 3.2.1.25 | from API rID32STR |
| 5327 | catalase | + | 1.11.1.6 | |
| 121896 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 5327 | cytochrome-c oxidase | - | 1.9.3.1 | |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 121896 | gamma-glutamyltransferase | - | 2.3.2.2 | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 121896 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 121896 | ornithine decarboxylase | - | 4.1.1.17 | |
| 121896 | oxidase | + | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68381 | urease | - | 3.5.1.5 | from API rID32STR |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 121896 | not determinedn.d. | - | - | - | - | - | - | - | - | - | + | + | + | + | - | - | - | - | +/- | - | - | +/- | + | - | - | - | + | + | + | + | + | + | + | - | - | + | + | + | - | - | + | - | - | - | - | - | - | - | - | +/- |
| @ref | ADH (Arg) | beta GLU | beta GAR | beta GUR | alpha GAL | PAL | RIB | MAN | SOR | LAC | TRE | RAF | SAC | LARA | DARL | Acid from alpha-cyclodextrinCDEX | Acetoin production (Voges Proskauer test)VP | Alanyl-Phenylalanyl-Proline arylamidaseAPPA | beta GAL | Pyrrolidonyl arylamidasePyrA | N-Acetyl-glucosaminidasebeta NAG | Glycyl-tryptophan arylamidaseGTA | HIP | GLYG | PUL | MAL | MEL | MLZ | Acidification of methyl beta-D-glucopyranosideMbeta DG | TAG | beta MAN | URE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5327 | - | - | + | - | +/- | - | - | - | - | + | + | + | + | - | - | - | - | + | + | + | + | + | - | - | + | + | - | - | - | - | - | - | |
| 5327 | - | - | + | - | - | - | - | - | - | + | + | + | + | - | - | - | - | + | +/- | + | + | + | - | - | + | + | - | - | +/- | - | - | - | |
| 5327 | - | +/- | + | - | + | - | - | - | - | + | + | + | + | - | - | - | - | + | + | + | + | + | - | - | + | + | - | - | - | - | - | - | |
| 5327 | - | - | - | - | - | - | - | - | - | + | + | + | + | - | - | - | - | + | - | - | - | - | - | - | +/- | + | - | - | - | - | - | - |
Global distribution of 16S sequence AY281084 (>99% sequence identity) for Streptococcus from Microbeatlas 
 Aquatic Samples |
1515 |
 Soil Samples |
819 |
 Animal Samples |
56551 |
 Plant Samples |
407 |
| Total Samples | 59292 |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 124043 | ASM190988v1 assembly for Streptococcus pneumoniae MMC_A07 | contig | GCA_001909885   | 1313.13854  | 8010658562  | 1313 | 65.3 | |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 20218 | Streptococcus pneumoniae ATCC 6303 16S ribosomal RNA gene, partial sequence | AY281084 | 1427 |  | 1313 | |
| 20218 | Streptococcus pneumoniae ATCC 6303 16S rRNA gene, partial sequence | U02920 | 386 | | 1313 | |
| 124043 | Streptococcus pneumoniae strain ATCC 6303 16S ribosomal RNA gene, partial sequence. | OR394090 | 386 | | 1313 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| A New Phage Lysin Isolated from the Oral Microbiome Targeting Streptococcus pneumoniae. | van der Kamp I, Draper LA, Smith MK, Buttimer C, Ross RP, Hill C. | Pharmaceuticals (Basel) | 10.3390/ph13120478 | 2020 | | |
| Metabolism | Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood. | Clancy E, Higgins O, Forrest MS, Boo TW, Cormican M, Barry T, Piepenburg O, Smith TJ. | BMC Infect Dis | 10.1186/s12879-015-1212-5 | 2015 | |
| Pathogenicity | Anti-inflammatory effects in LPS-induced macrophages and antibiofilm activity of the mannose-rich exopolysaccharide produced by Bacillus licheniformis B3-15. | Rizzo MG, Zammuto V, Spano A, Gugliandolo C, Calabrese G, Guglielmino S. | Heliyon | 10.1016/j.heliyon.2024.e38367 | 2024 | |
| Evidence of Reduced Virulence and Increased Colonization Among Pneumococcal Isolates of Serotype 3 Clade II Lineage in Mice. | Sekulovic O, Gallagher C, Lee J, Hao L, Zinonos S, Tan CY, Anderson A, Kanevsky I. | J Infect Dis | 10.1093/infdis/jiae038 | 2024 | | |
| Intranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections. | Cardoso KF, de Souza LRA, da Silva Santos BSA, de Carvalho KRA, da Silva Messias SG, de Faria Goncalves AP, Kano FS, Alves PA, da Silva Campos MA, Xavier MP, Garcia CC, Russo RC, Gazzinelli RT, Costa EA, da Silva Martins NR, Miyaji EN, de Magalhaes Vieira Machado A, Silva Araujo MS. | NPJ Vaccines | 10.1038/s41541-024-01033-5 | 2024 | | |
| Plasma attenuates endothelial injury compared to crystalloids in a ventilated rat pneumosepsis model. | van den Brink DP, Kleinveld DJB, Polet CA, Veltman H, Roelofs JJTH, Weber NC, Juffermans NP. | PLoS One | 10.1371/journal.pone.0319272 | 2025 | | |
| An insight into pyocyanin: production, characterization, and evaluation of its in vitro antibacterial, antifungal, antibiofilm and in vivo anti-schistosomal potency. | Eltarahony MM, Younis SS, Abdel Salam SA, Arafa FM. | BMC Microbiol | 10.1186/s12866-025-04248-1 | 2025 | | |
| Granulocyte-macrophage colony-stimulating factor reduces lung bacterial load following traumatic brain injury and hemorrhage polytrauma in a juvenile rat model. | Bahader GA, Warner T, Hall MW, Sribnick EA. | PLoS One | 10.1371/journal.pone.0323674 | 2025 | | |
| SiO2 nanoparticles as disruptors of endogenous resolution mechanisms of inflammatory responses that exacerbate pneumonia. | Tavares LP, Libreros S, Bitounis D, Nshimiyimana R, Demokritou P, Serhan CN, Levy BD. | Sci Rep | 10.1038/s41598-025-89700-y | 2025 | | |
| Intra-serotype variation of Streptococcus pneumoniae capsule and its quantification. | Eichner H, Wu C, Cammer M, Tran ENH, Hirst TR, Paton JC, Weiser JN. | Microbiol Spectr | 10.1128/spectrum.03087-24 | 2025 | | |
| Streptococcus pneumoniae serotype distribution in low- and middle-income countries of South Asia: Do we need to revisit the pneumococcal vaccine strategy? | Dhawale P, Shah S, Sharma K, Sikriwal D, Kumar V, Bhagawati A, Dhar S, Shetty P, Ahmed S. | Hum Vaccin Immunother | 10.1080/21645515.2025.2461844 | 2025 | | |
| Predictive signature of murine and human host response to typical and atypical pneumonia. | McCravy M, O'Grady N, Khan K, Betancourt-Quiroz M, Zaas AK, Treece AE, Yang Z, Que L, Henao R, Suchindran S, Ginsburg GS, Woods CW, McClain MT, Tsalik EL. | BMJ Open Respir Res | 10.1136/bmjresp-2023-002001 | 2024 | | |
| Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection. | Cho SJ, Pronko A, Yang J, Pagan K, Stout-Delgado H. | Cells | 10.3390/cells12040570 | 2023 | | |
| Pathogen class-specific transcriptional responses derived from PBMCs accurately discriminate between fungal, bacterial, and viral infections. | Steinbrink JM, Liu Y, Henao R, Tsalik EL, Ginsburg GS, Ramsburg E, Woods CW, McClain MT. | PLoS One | 10.1371/journal.pone.0311007 | 2024 | | |
| Serotype-Dependent Inhibition of Streptococcus pneumoniae Growth by Short-Chain Fatty Acids. | Lim S, Lee D, Jeong S, Park JW, Im J, Choi B, Gwak D, Yun CH, Seo HS, Han SH. | J Microbiol Biotechnol | 10.4014/jmb.2309.09003 | 2024 | | |
| Protective effect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection. | Guo Y, Sun Y, Wu H, Lu J, Lin Y, Zhu J, Lai M, Zhang M, Wang J, Zheng J. | World J Emerg Med | 10.5847/wjem.j.1920-8642.2024.014 | 2024 | | |
| Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies. | Brochut M, Heinonen T, Snaka T, Gilbert C, Le Roy D, Roger T. | Sci Rep | 10.1038/s41598-024-72039-1 | 2024 | | |
| A new candidate epitope-based vaccine against PspA PhtD of Streptococcus pneumoniae: a computational experimental approach. | Shafaghi M, Bahadori Z, Barzi SM, Afshari E, Madanchi H, Mousavi SF, Shabani AA. | Front Cell Infect Microbiol | 10.3389/fcimb.2023.1271143 | 2023 | | |
| RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. | Huang HR, Cho SJ, Harris RM, Yang J, Bermejo S, Sharma L, Dela Cruz CS, Xu JF, Stout-Delgado HW. | Am J Respir Cell Mol Biol | 10.1165/rcmb.2020-0312oc | 2021 | | |
| Pathogenicity | The host transcriptional response to superinfection by influenza A virus and Streptococcus pneumoniae. | Cohn O, Yankovitz G, Mandelboim M, Peshes-Yaloz N, Brandes R, Bacharach E, Gat-Viks I. | mSystems | 10.1128/msystems.01048-23 | 2024 | |
| Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease. | Ravi VR, Korkmaz FT, De Ana CL, Lu L, Shao FZ, Odom CV, Barker KA, Ramanujan A, Niszczak EN, Goltry WN, Martin IMC, Ha CT, Quinton LJ, Jones MR, Fine A, Welch JD, Chen F, Belkina AC, Mizgerd JP, Shenoy AT. | Cell Rep | 10.1016/j.celrep.2025.115294 | 2025 | | |
| Enzymology | Early detection of drug-resistant Streptococcus pneumoniae and Haemophilus influenzae by quantitative flow cytometry. | Sawada T, Katayama M, Takatani S, Ohiro Y. | Sci Rep | 10.1038/s41598-021-82186-4 | 2021 | |
| Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcuspneumoniae. | Thomas D, Yang J, Cho SJ, Stout-Delgado H. | Redox Biol | 10.1016/j.redox.2024.103329 | 2024 | | |
| Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae. | Pereverzeva L, Otto NA, Roelofs JJTH, de Vos AF, van der Poll T. | Respir Res | 10.1186/s12931-022-02168-6 | 2022 | | |
| Development of a dry powder formulation for pulmonary delivery of azithromycin-loaded nanoparticles. | Madrid Sani AT, Ramos-Rocha KLV, Sarcinelli MA, Chaves MHDC, Rocha HVA, Leo P, Cerize NNP, Zanin MHA, Feitosa VA, Rangel-Yagui CO. | J Pharm Pharm Sci | 10.3389/jpps.2024.13635 | 2024 | | |
| Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung. | Kang A, Ye G, Singh R, Afkhami S, Bavananthasivam J, Luo X, Vaseghi-Shanjani M, Aleithan F, Zganiacz A, Jeyanathan M, Xing Z. | EMBO Mol Med | 10.15252/emmm.202217084 | 2023 | | |
| The Effects of Heparan Sulfate Infusion on Endothelial and Organ Injury in a Rat Pneumosepsis Model. | van den Brink DP, Kleinveld DJB, Bongers A, Vos J, Roelofs JJTH, Weber NC, van Buul JD, Juffermans NP. | J Clin Med | 10.3390/jcm12206438 | 2023 | | |
| Antimicrobial activities and phytochemical properties of Blumea balsamifera against pathogenic microorganisms. | Ismail NA, Matawali A, Kanak FA, Lee PC, How SE, Goh LPW, Gansau JA. | J Med Life | 10.25122/jml-2021-0296 | 2022 | | |
| Chronic ethanol exposure impairs alveolar leukocyte infiltration during pneumococcal pneumonia, leading to an increased bacterial burden despite increased CXCL1 and nitric oxide levels. | Martins FRB, de Oliveira MD, Souza JAM, Queiroz-Junior CM, Lobo FP, Teixeira MM, Malacco NL, Soriani FM. | Front Immunol | 10.3389/fimmu.2023.1175275 | 2023 | | |
| Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan. | Machata S, Bertsche U, Hoffmann F, Fattal ZM, Kage F, Flak M, Iliou ANJ, Hillmann F, von Eggeling F, Slevogt H, Brakhage AA, Jacobsen ID. | EMBO Rep | 10.1038/s44319-025-00508-3 | 2025 | | |
| The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model. | van den Brink DP, Kleinveld DJB, Bongers A, Vos J, Roelofs JJTH, Weber NC, van Buul JD, Juffermans NP. | Intensive Care Med Exp | 10.1186/s40635-023-00549-9 | 2023 | | |
| Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice. | McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Orlicky DJ, Kovacs EJ. | Front Aging | 10.3389/fragi.2022.859991 | 2022 | | |
| Pathogenicity | Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2. | Hirose K, Li SZ, Gill R, Hartsock J. | J Assoc Res Otolaryngol | 10.1007/s10162-024-00935-4 | 2024 | |
| Enzymology | Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. | Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. | Am J Physiol Lung Cell Mol Physiol | 10.1152/ajplung.00132.2019 | 2019 | |
| Metabolism | Comparison of Immunogenicity and Protection of Two Pneumococcal Protein Vaccines Based on PsaA and PspA. | Yu J, Li B, Chen X, Lu J, Wang D, Gu T, Kong W, Wu Y. | Infect Immun | 10.1128/iai.00916-17 | 2018 | |
| Immune response induced in mice by a hybrid rPotD-PdT pneumococcal protein. | Rojas Converso T, Goulart C, Rodriguez D, Guerra MES, Darrieux M, Leite LCC. | PLoS One | 10.1371/journal.pone.0273017 | 2022 | | |
| Investigation of Upper Respiratory Carriage of Bacterial Pathogens among University Students in Kampar, Malaysia. | Ong HH, Toh WK, Thong LY, Phoon LQ, Clarke SC, Cheah ESG. | Trop Med Infect Dis | 10.3390/tropicalmed8050269 | 2023 | | |
| Pathogenicity | Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection. | P Tavares L, Bruggemann TR, M Rezende R, G Machado M, Cagnina RE, Shay AE, C Garcia C, Nijmeh J, M Teixeira M, Levy BD. | mBio | 10.1128/mbio.01267-22 | 2022 | |
| Metabolism | Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. | Cho SJ, Plataki M, Mitzel D, Lowry G, Rooney K, Stout-Delgado H. | Exp Gerontol | 10.1016/j.exger.2017.11.010 | 2018 | |
| Demonstration of N,N-Dimethyldithiocarbamate as a Copper-Dependent Antibiotic against Multiple Upper Respiratory Tract Pathogens. | Menghani SV, Rivera A, Neubert M, Hagerty JR, Lewis L, Galgiani JN, Jolly ER, Alvin JW, Johnson MDL. | Microbiol Spectr | 10.1128/spectrum.00778-21 | 2021 | | |
| Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy. | Kelly MS, Plunkett C, Yu Y, Aquino JN, Patel SM, Hurst JH, Young RR, Smieja M, Steenhoff AP, Arscott-Mills T, Feemster KA, Boiditswe S, Leburu T, Mazhani T, Patel MZ, Rawls JF, Jawahar J, Shah SS, Polage CR, Cunningham CK, Seed PC. | ISME J | 10.1038/s41396-021-01108-4 | 2022 | | |
| Pathogenicity | Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection. | Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ. | Front Immunol | 10.3389/fimmu.2022.884719 | 2022 | |
| Culture-independent identification of bloodstream infections from whole blood: prospective evaluation in specimens of known infection status. | Iyer V, Castro D, Malla B, Panda B, Rabson AR, Horowitz G, Heger N, Gupta K, Singer A, Norwitz ER. | J Clin Microbiol | 10.1128/jcm.01498-23 | 2024 | | |
| Metagenomic nanopore sequencing for exploring the nature of antimicrobial metabolites of Bacillus haynesii. | Eltokhy MA, Saad BT, Eltayeb WN, Alshahrani MY, Radwan SMR, Aboshanab KM, Ashour MSE. | AMB Express | 10.1186/s13568-024-01701-8 | 2024 | | |
| Mathematical modeling of postcoinfection with influenza A virus and Streptococcus pneumoniae, with implications for pneumonia and COPD-risk assessment. | Cheng YH, You SH, Lin YJ, Chen SC, Chen WY, Chou WC, Hsieh NH, Liao CM. | Int J Chron Obstruct Pulmon Dis | 10.2147/copd.s138295 | 2017 | | |
| Virulence-Associated Characteristics of Serotype 14 and Serogroup 9 Streptococcus pneumoniae Clones Circulating in Brazil: Association of Penicillin Non-susceptibility With Transparent Colony Phenotype Variants. | Pinto TCA, Costa NS, Pina SECM, Souza ARV, Oliveira LMA, Moura CAB, Kegele FCO, Merquior VLC, Botelho ACN, Peralta JM, Teixeira LM. | Front Microbiol | 10.3389/fmicb.2020.02009 | 2020 | | |
| Metabolism | NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection. | Cho SJ, Rooney K, Choi AMK, Stout-Delgado HW. | Am J Physiol Lung Cell Mol Physiol | 10.1152/ajplung.00393.2017 | 2018 | |
| Pathogenicity | Glucocorticoid-Induced Leucine Zipper Alleviates Lung Inflammation and Enhances Bacterial Clearance during Pneumococcal Pneumonia. | Souza JAM, Carvalho AFS, Grossi LC, Zaidan I, de Oliveira LC, Vago JP, Cardoso C, Machado MG, Souza GVS, Queiroz-Junior CM, Morand EF, Bruscoli S, Riccardi C, Teixeira MM, Tavares LP, Sousa LP. | Cells | 10.3390/cells11030532 | 2022 | |
| Identification of 6,8-ditrifluoromethyl halogenated phenazine as a potent bacterial biofilm-eradicating agent. | Gao Q, Yang H, Sheiber J, Bartolomeu Halicki PC, Liu K, Blanco D, Milhous S, Jin S, Rohde KH, Fleeman RM, Huigens Iii RW. | Org Biomol Chem | 10.1039/d4ob02011a | 2025 | | |
| An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications. | Huigens Iii RW, Yang H, Liu K, Kim YS, Jin S. | Org Biomol Chem | 10.1039/d1ob01107c | 2021 | | |
| Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus. | Anaya EP, Lin X, Todd EM, Szasz TP, Morley SC. | J Immunol | 10.4049/jimmunol.2000899 | 2021 | | |
| Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae. | Aguinagalde Salazar L, den Boer MA, Castenmiller SM, Zwarthoff SA, de Haas C, Aerts PC, Beurskens FJ, Schuurman J, Heck AJR, van Kessel K, Rooijakkers SHM. | Elife | 10.7554/elife.80669 | 2023 | | |
| Neutrophil Extracellular Traps as an Exacerbating Factor in Bacterial Pneumonia. | Sanders NL, Martin IMC, Sharma A, Jones MR, Quinton LJ, Bosmann M, Mizgerd JP. | Infect Immun | 10.1128/iai.00491-21 | 2022 | | |
| Antimicrobial and Antibiofilm Activities of Weissella cibaria against Pathogens of Upper Respiratory Tract Infections. | Yeu JE, Lee HG, Park GY, Lee J, Kang MS. | Microorganisms | 10.3390/microorganisms9061181 | 2021 | | |
| Pathogenicity | Urban Particles Elevated Streptococcus pneumoniae Biofilms, Colonization of the Human Middle Ear Epithelial Cells, Mouse Nasopharynx and Transit to the Middle Ear and Lungs. | Yadav MK, Go YY, Jun I, Chae SW, Song JJ. | Sci Rep | 10.1038/s41598-020-62846-7 | 2020 | |
| Pathogenicity | Comparative In Vivo Efficacies of Tedizolid in Neutropenic versus Immunocompetent Murine Streptococcus pneumoniae Lung Infection Models. | Abdelraouf K, Nicolau DP. | Antimicrob Agents Chemother | 10.1128/aac.01957-16 | 2017 | |
| Traditional Japanese Herbal Medicine Hochu-Ekki-to Promotes Pneumococcal Colonization Clearance via Macrophage Activation and Interleukin 17A Production in Mice. | Nakakubo S, Kimura S, Mimura K, Kajiwara C, Ishii Y, Konno S, Tateda K. | Front Cell Infect Microbiol | 10.3389/fcimb.2020.569158 | 2020 | | |
| Exposure to Porphyromonas gingivalis Induces Production of Proinflammatory Cytokine via TLR2 from Human Respiratory Epithelial Cells. | Watanabe N, Yokoe S, Ogata Y, Sato S, Imai K. | J Clin Med | 10.3390/jcm9113433 | 2020 | | |
| Conjugation of PspA4Pro with Capsular Streptococcus pneumoniae Polysaccharide Serotype 14 Does Not Reduce the Induction of Cross-Reactive Antibodies. | da Silva MA, Converso TR, Goncalves VM, Leite LCC, Tanizaki MM, Barazzone GC. | Clin Vaccine Immunol | 10.1128/cvi.00118-17 | 2017 | | |
| Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae. | Salcedo-Rivillas C, Debrie AS, Miyaji EN, Ferreira JM, Raw I, Locht C, Ho PL, Mielcarek N, Oliveira ML. | Clin Vaccine Immunol | 10.1128/cvi.00134-14 | 2014 | | |
| Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection. | Masomian M, Ahmad Z, Gew LT, Poh CL. | Vaccines (Basel) | 10.3390/vaccines8010132 | 2020 | | |
| Metabolism | Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. | Maier BB, Hladik A, Lakovits K, Korosec A, Martins R, Kral JB, Mesteri I, Strobl B, Muller M, Kalinke U, Merad M, Knapp S. | Eur J Immunol | 10.1002/eji.201546201 | 2016 | |
| Metabolism | Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection. | Han L, Zhang F, Liu Y, Yu J, Zhang Q, Ye X, Song H, Zheng C, Han B. | Clin Transl Med | 10.1002/ctm2.850 | 2022 | |
| Genetics | Characterization of Bifidobacterium asteroides Isolates. | Pino A, Benkaddour B, Inturri R, Amico P, Vaccaro SC, Russo N, Vaccalluzzo A, Agolino G, Caggia C, Miloud H, Randazzo CL. | Microorganisms | 10.3390/microorganisms10030655 | 2022 | |
| Enhanced IL-1beta production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae. | Rodriguez AE, Bogart C, Gilbert CM, McCullers JA, Smith AM, Kanneganti TD, Lupfer CR. | PLoS One | 10.1371/journal.pone.0212236 | 2019 | | |
| Evaluation of a vaccine formulation against Streptococcus pneumoniae based on choline-binding proteins. | Miyaji EN, Vadesilho CF, Oliveira ML, Zelanis A, Briles DE, Ho PL. | Clin Vaccine Immunol | 10.1128/cvi.00692-14 | 2015 | | |
| Integrative In Silico and Experimental Characterization of Endolysin LysPALS22: Structural Diversity, Ligand Binding Affinity, and Heterologous Expression. | Nawaz N, Nawaz S, Hussain A, Anayat M, Wen S, Wang F. | Int J Mol Sci | 10.3390/ijms26178579 | 2025 | | |
| Pathogenicity | Development of a model for anemia of inflammation that is relevant to critical care. | Boshuizen M, van Bruggen R, Zaat SA, Schultz MJ, Aguilera E, Motos A, Senussi T, Idone FA, Pelosi P, Torres A, Bassi GL, Juffermans NP. | Intensive Care Med Exp | 10.1186/s40635-019-0261-2 | 2019 | |
| Metabolism | Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model. | Perez E, Baker JR, Di Giandomenico S, Kermani P, Parker J, Kim K, Yang J, Barnes PJ, Vaulont S, Scandura JM, Donnelly LE, Stout-Delgado H, Cloonan SM. | J Immunol | 10.4049/jimmunol.1901284 | 2020 | |
| Metabolism | Heat-Killed Fusobacterium nucleatum Triggers Varying Heme-Related Inflammatory and Stress Responses Depending on Primary Human Respiratory Epithelial Cell Type. | Koike R, Cueno ME, Nodomi K, Tamura M, Kamio N, Tanaka H, Kotani A, Imai K. | Molecules | 10.3390/molecules25173839 | 2020 | |
| Pathogenicity | Gammaherpesvirus Alters Alveolar Macrophages According to the Host Genetic Background and Promotes Beneficial Inflammatory Control over Pneumovirus Infection. | Gilliaux G, Desmecht D. | Viruses | 10.3390/v14010098 | 2022 | |
| Treatment with broadly neutralizing influenza antibodies reduces severity of secondary pneumococcal pneumonia in mice. | van Someren Greve F, van der Sluijs KF, Tuip AM, Schultz MJ, de Jong MD, Juffermans NP. | J Med Virol | 10.1002/jmv.25212 | 2018 | | |
| Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone. | Plataki M, Cho SJ, Harris RM, Huang HR, Yun HS, Schiffer KT, Stout-Delgado HW. | Sci Rep | 10.1038/s41598-018-37438-1 | 2019 | | |
| Conserved surface accessible nucleoside ABC transporter component SP0845 is essential for pneumococcal virulence and confers protection in vivo. | Saxena S, Khan N, Dehinwal R, Kumar A, Sehgal D. | PLoS One | 10.1371/journal.pone.0118154 | 2015 | | |
| Phenotypic and genotypic features of first biofilm forming nasopharyngeal colonized Streptococcus pneumoniae isolates. | Mousavi SF, Mirzaei B, Shaghaghi B, Jalali P, Setayesh T, Moosavi SH. | Iran J Microbiol | 2017 | | ||
| Metabolism | Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia. | Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL. | Infect Immun | 10.1128/iai.00550-19 | 2019 | |
| Controlled inflammatory responses in the lungs are associated with protection elicited by a pneumococcal surface protein A-based vaccine against a lethal respiratory challenge with Streptococcus pneumoniae in mice. | Lima FA, Ferreira DM, Moreno AT, Ferreira PC, Palma GM, Ferreira JM, Raw I, Miyaji EN, Ho PL, Oliveira ML. | Clin Vaccine Immunol | 10.1128/cvi.00171-12 | 2012 | | |
| Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR. | Rosana Y, Prilandari LI, Ajisman R, Hartono TS, Yasmon A. | Iran J Microbiol | 10.18502/ijm.v12i6.5024 | 2020 | | |
| Pathogenicity | Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection. | Rich HE, McCourt CC, Zheng WQ, McHugh KJ, Robinson KM, Wang J, Alcorn JF. | Infect Immun | 10.1128/iai.00114-19 | 2019 | |
| Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-beta production during Streptococcus pneumoniae infection. | Mitzel DN, Lowry V, Shirali AC, Liu Y, Stout-Delgado HW. | J Immunol | 10.4049/jimmunol.1303090 | 2014 | | |
| Biotechnology | Validation of the Peel Plate Staphylococcus Aureus (SA) Test for Enumeration of S. aureus in Selected Foods and Non-Cultured Dairy Products: AOAC Performance Tested MethodSM 082401. | Salter RS, Durbin GW, Li S, Gilbert M, Crowley ES, Deterding A, Bastin B. | J AOAC Int | 10.1093/jaoacint/qsae083 | 2025 | |
| Pathogenicity | Time-resolved mRNA and miRNA expression profiling reveals crucial coregulation of molecular pathways involved in epithelial-pneumococcal interactions. | Li H, Lin L, Chong L, Gu S, Wen S, Yu G, Hu X, Dong L, Zhang H, Li C. | Immunol Cell Biol | 10.1111/imcb.12371 | 2020 | |
| Pathogenicity | Receptor for Advanced Glycation End Products (RAGE) Mediates Cognitive Impairment Triggered by Pneumococcal Meningitis. | Giridharan VV, Generoso JS, Collodel A, Dominguini D, Faller CJ, Tardin F, Bhatti GS, Petronilho F, Dal-Pizzol F, Barichello T. | Neurotherapeutics | 10.1007/s13311-020-00917-3 | 2021 | |
| Metabolism | Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis. | Kloek AT, Seron MV, Schmand B, Tanck MWT, van der Ende A, Brouwer MC, van de Beek D. | Acta Neuropathol Commun | 10.1186/s40478-020-01100-7 | 2021 | |
| Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC. | Vadesilho CF, Ferreira DM, Gordon SB, Briles DE, Moreno AT, Oliveira ML, Ho PL, Miyaji EN. | Clin Vaccine Immunol | 10.1128/cvi.00239-14 | 2014 | | |
| Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities. | de Lima Neto J, Menezes PH. | Beilstein J Org Chem | 10.3762/bjoc.19.31 | 2023 | | |
| Enzymology | Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples. | de Filippis I, de Andrade CF, Caldeira N, de Azevedo AC, de Almeida AE. | Braz J Infect Dis | 10.1016/j.bjid.2016.04.005 | 2016 | |
| Lacticaseibacillus rhamnosus CA15 (DSM 33960) as a Candidate Probiotic Strain for Human Health. | Pino A, Vaccalluzzo A, Caggia C, Balzaretti S, Vanella L, Sorrenti V, Ronkainen A, Satokari R, Randazzo CL. | Nutrients | 10.3390/nu14224902 | 2022 | | |
| Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules. | Harding CL, Villarino NF, Valente E, Schwarzer E, Schmidt NW. | Front Cell Infect Microbiol | 10.3389/fcimb.2020.00328 | 2020 | | |
| Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae. | Kristian SA, Ota T, Bubeck SS, Cho R, Groff BC, Kubota T, Destito G, Martin C, Laudenslager J, Koriazova L, Tahara T, Kanda Y. | PLoS One | 10.1371/journal.pone.0154616 | 2016 | | |
| Competitive advantage of oral streptococci for colonization of the middle ear mucosa. | Jacob KM, Reguera G. | Biofilm | 10.1016/j.bioflm.2022.100067 | 2022 | | |
| Pathogenicity | Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. | Mancuso P, Curtis JL, Freeman CM, Peters-Golden M, Weinberg JB, Myers MG. | Am J Physiol Lung Cell Mol Physiol | 10.1152/ajplung.00447.2017 | 2018 | |
| Enzymology | Aerococcus urinae - A potent biofilm builder in endocarditis. | Yaban B, Kikhney J, Musci M, Petrich A, Schmidt J, Hajduczenia M, Schoenrath F, Falk V, Moter A. | PLoS One | 10.1371/journal.pone.0231827 | 2020 | |
| Multi-Functional Potential of Lactic Acid Bacteria Strains and Antimicrobial Effects in Minimally Processed Pomegranate (Punica granatum L. cv Jolly Red) Arils. | Ben Farhat L, Romeo FV, Foti P, Russo N, Randazzo CL, Caggia C, Abidi F. | Microorganisms | 10.3390/microorganisms10101876 | 2022 | | |
| A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis. | Pino A, Rapisarda AMC, Vitale SG, Cianci S, Caggia C, Randazzo CL, Cianci A. | Sci Rep | 10.1038/s41598-021-81931-z | 2021 | | |
| Pathogenicity | CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection. | Tavares LP, Garcia CC, Machado MG, Queiroz-Junior CM, Barthelemy A, Trottein F, Siqueira MM, Brandolini L, Allegretti M, Machado AM, de Sousa LP, Teixeira MM. | Front Immunol | 10.3389/fimmu.2017.01799 | 2017 | |
| Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. | Kasanmoentalib ES, Valls Seron M, Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Schwaeble WJ, Brouwer MC, Brouwer MC, van de Beek D. | J Neuroinflammation | 10.1186/s12974-016-0770-9 | 2017 | | |
| Metabolism | Cytokine Cocktail Promotes Alveolar Macrophage Reconstitution and Functional Maturation in a Murine Model of Haploidentical Bone Marrow Transplantation. | Hong C, Lu H, Jin R, Huang X, Chen M, Dai X, Gong F, Dong H, Wang H, Gao XM. | Front Immunol | 10.3389/fimmu.2021.719727 | 2021 | |
| In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A. | Afshari E, Cohan RA, Sotoodehnejadnematalahi F, Mousavi SF. | J Transl Med | 10.1186/s12967-022-03864-z | 2023 | | |
| Enzymology | Detection of vaginal lactobacilli as probiotic candidates. | Pino A, Bartolo E, Caggia C, Cianci A, Randazzo CL. | Sci Rep | 10.1038/s41598-019-40304-3 | 2019 | |
| Aggregation of Streptococcus pneumoniae by a pneumococcal capsular polysaccharide-specific human monoclonal IgM correlates with antibody efficacy in vivo. | Fabrizio K, Manix C, Guimaraes AJ, Nosanchuk JD, Pirofski LA. | Clin Vaccine Immunol | 10.1128/cvi.00410-09 | 2010 | | |
| Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling. | Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, Rangel-Moreno J, Norton EB, Kolls JK. | Sci Immunol | 10.1126/sciimmunol.abf1198 | 2021 | | |
| Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag-/- Mice. | Felix KM, Jaimez IA, Nguyen TV, Ma H, Raslan WA, Klinger CN, Doyle KP, Wu HJ. | Front Cell Infect Microbiol | 10.3389/fcimb.2018.00118 | 2018 | | |
| Antimicrobial Activity of Calixarenes and Related Macrocycles. | Shurpik DN, Padnya PL, Stoikov II, Cragg PJ. | Molecules | 10.3390/molecules25215145 | 2020 | | |
| Cirrhosis-induced defects in innate pulmonary defenses against Streptococcus pneumoniae. | Propst-Graham KL, Preheim LC, Vander Top EA, Snitily MU, Gentry-Nielsen MJ. | BMC Microbiol | 10.1186/1471-2180-7-94 | 2007 | | |
| Pathogenicity | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. | Osborne CS, Neckermann G, Fischer E, Pecanka R, Yu D, Manni K, Goldovitz J, Amaral K, Dzink-Fox J, Ryder NS. | Antimicrob Agents Chemother | 10.1128/aac.00026-09 | 2009 | |
| Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection. | Shirey KA, Perkins DJ, Lai W, Zhang W, Fernando LR, Gusovsky F, Blanco JCG, Vogel SN. | mBio | 10.1128/mbio.00810-19 | 2019 | | |
| Pathogenicity | Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection. | Wang T, Wyrick KL, Pecka MR, Wills TB, Vorderstrasse BA. | Int Immunopharmacol | 10.1016/j.intimp.2012.05.008 | 2012 | |
| Pathogenicity | Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization. | Yildiz S, Pereira Bonifacio Lopes JP, Berge M, Gonzalez-Ruiz V, Baud D, Kloehn J, Boal-Carvalho I, Schaeren OP, Schotsaert M, Hathaway LJ, Rudaz S, Viollier PH, Hapfelmeier S, Francois P, Schmolke M. | Elife | 10.7554/elife.53581 | 2020 | |
| Enzymology | High prevalence of antibiotic resistance in nasopharyngeal bacterial isolates from healthy children in rural Uganda: A cross-sectional study. | Rutebemberwa E, Mpeka B, Pariyo G, Peterson S, Mworozi E, Bwanga F, Kallander K. | Ups J Med Sci | 10.3109/03009734.2015.1072606 | 2015 | |
| Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization. | Chen YH, Yeung F, Lacey KA, Zaldana K, Lin JD, Bee GCW, McCauley C, Barre RS, Liang SH, Hansen CB, Downie AE, Tio K, Weiser JN, Torres VJ, Bennett RJ, Loke P, Graham AL, Cadwell K. | Sci Immunol | 10.1126/sciimmunol.add6910 | 2023 | | |
| Piacentinu Ennese PDO Cheese as Reservoir of Promising Probiotic Bacteria. | Pino A, Russo N, Van Hoorde K, De Angelis M, Sferrazzo G, Randazzo CL, Caggia C. | Microorganisms | 10.3390/microorganisms7080254 | 2019 | | |
| Pathogenicity | Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats. | Hofstra JJ, Cornet AD, de Rooy BF, Vlaar AP, van der Poll T, Levi M, Zaat SA, Schultz MJ. | Crit Care | 10.1186/cc8040 | 2009 | |
| Phenotype | CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens. | Kress E, Merres J, Albrecht LJ, Hammerschmidt S, Pufe T, Tauber SC, Brandenburg LO. | Cell Commun Signal | 10.1186/s12964-017-0190-1 | 2017 | |
| Targeting the complement system in bacterial meningitis. | Koelman DLH, Brouwer MC, van de Beek D. | Brain | 10.1093/brain/awz222 | 2019 | | |
| Characterization of colony morphology variants isolated from Streptococcus pneumoniae biofilms. | Allegrucci M, Sauer K. | J Bacteriol | 10.1128/jb.01369-06 | 2007 | | |
| Correlation between in vitro complement deposition and passive mouse protection of anti-pneumococcal surface protein A monoclonal antibodies. | Khan N, Qadri RA, Sehgal D. | Clin Vaccine Immunol | 10.1128/cvi.00001-14 | 2015 | | |
| Population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission. | Thors V, Morales-Aza B, Pidwill G, Vipond I, Muir P, Finn A. | Hum Vaccin Immunother | 10.1080/21645515.2015.1090069 | 2016 | | |
| Complement factor H contributes to mortality in humans and mice with bacterial meningitis. | Kasanmoentalib ES, Valls Seron M, Engelen-Lee JY, Tanck MW, Pouw RB, van Mierlo G, Wouters D, Pickering MC, van der Ende A, Kuijpers TW, Brouwer MC, van de Beek D. | J Neuroinflammation | 10.1186/s12974-019-1675-1 | 2019 | | |
| Pathogenicity | Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia. | van den Boogaard FE, Hofstra JJ, van 't Veer C, Levi MM, Roelofs JJ, van der Poll T, Schultz MJ. | PLoS One | 10.1371/journal.pone.0127261 | 2015 | |
| Metabolism | Moraxella catarrhalis outer membrane vesicles carry beta-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin. | Schaar V, Nordstrom T, Morgelin M, Riesbeck K. | Antimicrob Agents Chemother | 10.1128/aac.01772-10 | 2011 | |
| Differential Identification of Mycobacterial Species Using High-Resolution Melting Analysis. | Khosravi AD, Hashemzadeh M, Hashemi Shahraki A, Teimoori A. | Front Microbiol | 10.3389/fmicb.2017.02045 | 2017 | | |
| Cinnamaldehyde derivatives act as antimicrobial agents against Acinetobacter baumannii through the inhibition of cell division. | Chai WC, Whittall JJ, Polyak SW, Foo K, Li X, Dutschke CJ, Ogunniyi AD, Ma S, Sykes MJ, Semple SJ, Venter H. | Front Microbiol | 10.3389/fmicb.2022.967949 | 2022 | | |
| Pathogenicity | Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence. | Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, Periasamy H, Yeole R, Deshpande PK, Bhavsar S, Bhatia A, Ahdal J, Jain R, Patel M. | Drug Des Devel Ther | 10.2147/dddt.s229882 | 2019 | |
| A New Natural Defense Against Airborne Pathogens. | Edwards D, Hickey A, Batycky R, Griel L, Lipp M, Dehaan W, Clarke R, Hava D, Perry J, Laurenzi B, Curran AK, Beddingfield BJ, Roy CJ, Devlin T, Langer R. | QRB Discov | 10.1017/qrd.2020.9 | 2020 | | |
| Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial. | Kasanmoentalib ES, Valls Seron M, Morgan BP, Brouwer MC, van de Beek D. | J Neuroinflammation | 10.1186/s12974-015-0372-y | 2015 | | |
| V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. | Valls Seron M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, van de Beek D. | Acta Neuropathol Commun | 10.1186/s40478-016-0320-9 | 2016 | | |
| Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment. | Seiler BT, Cartwright M, Dinis ALM, Duffy S, Lombardo P, Cartwright D, Super EH, Lanzaro J, Dugas K, Super M, Ingber DE. | F1000Res | 10.12688/f1000research.17447.1 | 2019 | | |
| Neural signaling in the spleen controls B-cell responses to blood-borne antigen. | Mina-Osorio P, Rosas-Ballina M, Valdes-Ferrer SI, Al-Abed Y, Tracey KJ, Diamond B. | Mol Med | 10.2119/molmed.2012.00027 | 2012 | | |
| Immunization of mice with single PspA fragments induces antibodies capable of mediating complement deposition on different pneumococcal strains and cross-protection. | Moreno AT, Oliveira ML, Ferreira DM, Ho PL, Darrieux M, Leite LC, Ferreira JM, Pimenta FC, Andrade AL, Miyaji EN. | Clin Vaccine Immunol | 10.1128/cvi.00430-09 | 2010 | | |
| Pathogenicity | Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice. | Henderson MW, Madenspacher JH, Whitehead GS, Thomas SY, Aloor JJ, Gowdy KM, Fessler MB. | Environ Health Perspect | 10.1289/ehp1878 | 2017 | |
| Metabolism | GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation. | Cho SJ, Moon JS, Nikahira K, Yun HS, Harris R, Hong KS, Huang H, Choi AMK, Stout-Delgado H. | Thorax | 10.1136/thoraxjnl-2019-213571 | 2020 | |
| Metabolism | Critical Role of IL-22/IL22-RA1 Signaling in Pneumococcal Pneumonia. | Trevejo-Nunez G, Elsegeiny W, Conboy P, Chen K, Kolls JK. | J Immunol | 10.4049/jimmunol.1600528 | 2016 | |
| Metabolism | Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae. | Blok DC, van Lieshout MH, Hoogendijk AJ, Florquin S, de Boer OJ, Garlanda C, Mantovani A, van't Veer C, de Vos AF, van der Poll T. | J Innate Immun | 10.1159/000358239 | 2014 | |
| Adjunct Culture of Non-Starter Lactic Acid Bacteria for the Production of Provola Dei Nebrodi PDO Cheese: In Vitro Screening and Pilot-Scale Cheese-Making. | Randazzo CL, Liotta L, Angelis M, Celano G, Russo N, Hoorde KV, Chiofalo V, Pino A, Caggia C. | Microorganisms | 10.3390/microorganisms9010179 | 2021 | | |
| A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. | Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, Huigens RW. | J Med Chem | 10.1021/acs.jmedchem.1c00168 | 2021 | | |
| Pathogenicity | Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge. | Ulrich M, Albers C, Moller JG, Dalhoff A, Korfmann G, Kunkele F, Doring G. | Antimicrob Agents Chemother | 10.1128/aac.49.12.5119-5122.2005 | 2005 | |
| Metabolism | IL-22-binding protein exacerbates influenza, bacterial super-infection. | Abood RN, McHugh KJ, Rich HE, Ortiz MA, Tobin JM, Ramanan K, Robinson KM, Bomberger JM, Kolls JK, Manni ML, Pociask DA, Alcorn JF. | Mucosal Immunol | 10.1038/s41385-019-0188-7 | 2019 | |
| Compartmentalized ocular lymphatic system mediates eye-brain immunity. | Yin X, Zhang S, Lee JH, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo LH, Poulet M, Fischer S, Zhou T, Mohammed FS, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas JL, Saltzman WM, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. | Nature | 10.1038/s41586-024-07130-8 | 2024 | | |
| Phylogeny | Serotype distribution and susceptibility of Streptococcus pneumoniae isolates from pleural fluid in Spain from 1997 to 2008. | Fenoll A, Aguilar L, Vicioso MD, Gimenez MJ, Robledo O, Granizo JJ, Mendez C. | Antimicrob Agents Chemother | 10.1128/aac.00217-10 | 2010 | |
| Streptococcus pneumoniae-induced pneumonia and Citrobacter rodentium-induced gut infection differentially alter vitamin A concentrations in the lung and liver of mice. | Restori KH, McDaniel KL, Wray AE, Cantorna MT, Ross AC. | J Nutr | 10.3945/jn.113.186569 | 2014 | | |
| Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use. | Ramuta TZ, Sket T, Starcic Erjavec M, Kreft ME. | Front Bioeng Biotechnol | 10.3389/fbioe.2021.691522 | 2021 | | |
| Pathogenicity | Phenotypic and molecular characterization of optochin-resistant Streptococcus pneumoniae isolates from Brazil, with description of five novel mutations in the ATPC gene. | Pinto TC, Souza AR, de Pina SE, Costa NS, Borges Neto AA, Neves FP, Merquior VL, Dias CA, Peralta JM, Teixeira LM. | J Clin Microbiol | 10.1128/jcm.01168-13 | 2013 | |
| Pathogenicity | Antibacterial, Antifungal and Antibiofilm Activities of Silver Nanoparticles Supported by Crude Bioactive Metabolites of Bionanofactories Isolated from Lake Mariout. | Eltarahony M, Ibrahim A, El-Shall H, Ibrahim E, Althobaiti F, Fayad E. | Molecules | 10.3390/molecules26103027 | 2021 | |
| Pathogenicity | Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. | Korkmaz FT, Shenoy AT, Symer EM, Baird LA, Odom CV, Arafa EI, Dimbo EL, Na E, Molina-Arocho W, Brudner M, Standiford TJ, Mehta JL, Sawamura T, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. | JCI Insight | 10.1172/jci.insight.149955 | 2022 | |
| Enzymology | Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection. | Hoover J, Lewandowski T, Straub RJ, Novick SJ, DeMarsh P, Aubart K, Rittenhouse S, Zalacain M. | Antimicrob Agents Chemother | 10.1128/aac.01842-15 | 2016 | |
| Prevalence and impact of Streptococcus pneumoniae in adult cystic fibrosis patients: a retrospective chart review and capsular serotyping study. | Thornton CS, Brown EL, Alcantara J, Rabin HR, Parkins MD. | BMC Pulm Med | 10.1186/s12890-015-0041-z | 2015 | | |
| Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era. | Abdallah EM, Alhatlani BY, de Paula Menezes R, Martins CHG. | Plants (Basel) | 10.3390/plants12173077 | 2023 | | |
| Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h-TOP-IIbeta Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge. | Mohammed HA, Khan RA, Abdel-Hafez AA, Abdel-Aziz M, Ahmed E, Enany S, Mahgoub S, Al-Rugaie O, Alsharidah M, Aly MSA, Mehany ABM, Hegazy MM. | Molecules | 10.3390/molecules26030577 | 2021 | | |
| Metabolism | TMEM173 Drives Lethal Coagulation in Sepsis. | Zhang H, Zeng L, Xie M, Liu J, Zhou B, Wu R, Cao L, Kroemer G, Wang H, Billiar TR, Zeh HJ, Kang R, Jiang J, Yu Y, Tang D. | Cell Host Microbe | 10.1016/j.chom.2020.02.004 | 2020 | |
| Lung-resident memory B cells protect against bacterial pneumonia. | Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. | J Clin Invest | 10.1172/jci141810 | 2021 | | |
| Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Staphylococcus aureus Biofilms. | Liu K, Brivio M, Xiao T, Norwood VM, Kim YS, Jin S, Papagni A, Vaghi L, Huigens RW. | ACS Infect Dis | 10.1021/acsinfecdis.1c00402 | 2022 | | |
| R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. | Hoogendijk AJ, Roelofs JJ, Duitman J, van Lieshout MH, Blok DC, van der Poll T, Wieland CW. | Mol Med | 10.2119/molmed.2012.00033 | 2012 | | |
| Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia. | Achouiti A, de Vos AF, de Beer R, Florquin S, van 't Veer C, van der Poll T. | J Innate Immun | 10.1159/000348739 | 2013 | | |
| Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. | Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. | Mucosal Immunol | 10.1038/mi.2017.43 | 2018 | | |
| Development of primary invasive pneumococcal disease caused by serotype 1 pneumococci is driven by early increased type I interferon response in the lung. | Hughes CE, Harvey RM, Plumptre CD, Paton JC. | Infect Immun | 10.1128/iai.02067-14 | 2014 | | |
| Pathogenicity | Susceptibility of recently collected Spanish pneumococci nonsusceptible to oral penicillin from serotypes not included in the 7-valent conjugate vaccine. | Fenoll A, Aguilar L, Gimenez MJ, Vicioso MD, Robledo O, Granizo JJ, Coronel P. | Antimicrob Agents Chemother | 10.1128/aac.01594-09 | 2010 | |
| Metabolism | Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. | Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. | Infect Immun | 10.1128/iai.00983-13 | 2014 | |
| Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia. | Todd EM, Ramani R, Szasz TP, Morley SC. | Sci Adv | 10.1126/sciadv.aax3387 | 2019 | | |
| Pathogenicity | In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci. | Llull D, Rivas L, Garcia E. | Antimicrob Agents Chemother | 10.1128/aac.01428-06 | 2007 | |
| Roles of interleukin-11 during acute bacterial pneumonia. | Traber KE, Dimbo EL, Symer EM, Korkmaz FT, Jones MR, Mizgerd JP, Quinton LJ. | PLoS One | 10.1371/journal.pone.0221029 | 2019 | | |
| PspA family fusion proteins delivered by attenuated Salmonella enterica serovar Typhimurium extend and enhance protection against Streptococcus pneumoniae. | Xin W, Li Y, Mo H, Roland KL, Curtiss R. | Infect Immun | 10.1128/iai.00486-09 | 2009 | | |
| Phenotypic characterization of Streptococcus pneumoniae biofilm development. | Allegrucci M, Hu FZ, Shen K, Hayes J, Ehrlich GD, Post JC, Sauer K. | J Bacteriol | 10.1128/jb.188.7.2325-2335.2006 | 2006 | | |
| Pathogenicity | In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens. | Purnapatre KP, Rao M, Pandya M, Khanna A, Chaira T, Bambal R, Upadhyay DJ, Masuda N. | Antimicrob Agents Chemother | 10.1128/aac.01987-17 | 2018 | |
| Pathogenicity | Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus. | Butler D, Chen D, O'Dwyer K, Lewandowski T, Aubart K, Zalacain M. | Antimicrob Agents Chemother | 10.1128/aac.01292-13 | 2014 | |
| Enzymology | Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa. | Pettit GR, Ye Q, Herald DL, Hogan F, Pettit RK. | J Nat Prod | 10.1021/np9004689 | 2010 | |
| Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model. | Roche H, Hakansson A, Hollingshead SK, Briles DE. | Infect Immun | 10.1128/iai.71.3.1033-1041.2003 | 2003 | | |
| Metabolism | Genetic Analysis of Mutacin B-Ny266, a Lantibiotic Active against Caries Pathogens. | Dufour D, Barbour A, Chan Y, Cheng M, Rahman T, Thorburn M, Stewart C, Finer Y, Gong SG, Levesque CM. | J Bacteriol | 10.1128/jb.00762-19 | 2020 | |
| Metabolism | Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. | Shak JR, Ludewick HP, Howery KE, Sakai F, Yi H, Harvey RM, Paton JC, Klugman KP, Vidal JE. | mBio | 10.1128/mbio.00655-13 | 2013 | |
| Metabolism | Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain. | Jansen S, Podschun R, Leib SL, Grotzinger J, Oestern S, Michalek M, Pufe T, Brandenburg LO. | Infect Immun | 10.1128/iai.01265-12 | 2013 | |
| Pathogenicity | Morphine potentiates LPS-induced autophagy initiation but inhibits autophagosomal maturation through distinct TLR4-dependent and independent pathways. | Wan J, Ma J, Anand V, Ramakrishnan S, Roy S. | Acta Physiol (Oxf) | 10.1111/apha.12506 | 2015 | |
| Pathogenicity | Evolution of clonal and susceptibility profiles of serotype 19A Streptococcus pneumoniae among invasive isolates from children in Spain, 1990 to 2008. | Tarrago D, Aguilar L, Garcia R, Gimenez MJ, Granizo JJ, Fenoll A. | Antimicrob Agents Chemother | 10.1128/aac.01494-10 | 2011 | |
| First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. | Saluzzo S, Gorki AD, Rana BMJ, Martins R, Scanlon S, Starkl P, Lakovits K, Hladik A, Korosec A, Sharif O, Warszawska JM, Jolin H, Mesteri I, McKenzie ANJ, Knapp S. | Cell Rep | 10.1016/j.celrep.2017.01.071 | 2017 | | |
| Pathogenicity | The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung. | Galvao I, Tavares LP, Correa RO, Fachi JL, Rocha VM, Rungue M, Garcia CC, Cassali G, Ferreira CM, Martins FS, Oliveira SC, Mackay CR, Teixeira MM, Vinolo MAR, Vieira AT. | Front Immunol | 10.3389/fimmu.2018.00142 | 2018 | |
| Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death. | Scur M, Mahmoud AB, Dey S, Abdalbarri F, Stylianides I, Medina-Luna D, Gamage GS, Woblistin A, Wilson ANM, Zein HS, Stueck A, Wight A, Aguilar OA, Di Cara F, Parsons BD, Rahim MMA, Carlyle JR, Makrigiannis AP. | Nat Commun | 10.1038/s41467-022-34935-w | 2022 | | |
| Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. | Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, Van der Ende A, Van der Poll T, Van de Beek D. | BMC Infect Dis | 10.1186/1471-2334-13-358 | 2013 | | |
| Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia. | Dessing MC, de Vos AF, Florquin S, van der Poll T. | Infect Immun | 10.1128/iai.00977-06 | 2006 | | |
| Metabolism | NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. | Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabon MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM. | Nat Med | 10.1038/nm.4153 | 2016 | |
| Metabolism | The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. | Braun BJ, Slowik A, Leib SL, Lucius R, Varoga D, Wruck CJ, Jansen S, Podschun R, Pufe T, Brandenburg LO. | J Neuroinflammation | 10.1186/1742-2094-8-11 | 2011 | |
| Effect of essential oil of traditional two Saudi mint types and its possible role in cardiovascular and throat health. | Ahmed AM, Ozbak HA, Hemeg HA. | Int J Clin Exp Med | 2015 | | ||
| Metabolism | Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation. | Weiser JN, Roche AM, Hergott CB, LaRose MI, Connolly T, Jorgensen WL, Leng L, Bucala R, Das R. | J Infect Dis | 10.1093/infdis/jiv262 | 2015 | |
| Metabolism | Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza. | Chen WH, Toapanta FR, Shirey KA, Zhang L, Giannelou A, Page C, Frieman MB, Vogel SN, Cross AS. | Immunol Lett | 10.1016/j.imlet.2011.10.009 | 2012 | |
| Pathogenicity | Antimicrobial properties of MX-2401, an expanded-spectrum lipopeptide active in the presence of lung surfactant. | Dugourd D, Yang H, Elliott M, Siu R, Clement JJ, Straus SK, Hancock RE, Rubinchik E. | Antimicrob Agents Chemother | 10.1128/aac.00322-11 | 2011 | |
| Phylogeny | Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997-2009. | Fenoll A, Aguilar L, Vicioso MD, Gimenez MJ, Robledo O, Granizo JJ. | BMC Infect Dis | 10.1186/1471-2334-11-239 | 2011 | |
| Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes. | Damjanovic D, Khera A, Medina MF, Ennis J, Turner JD, Gauldie J, Xing Z. | Mol Ther Methods Clin Dev | 10.1038/mtm.2014.5 | 2014 | | |
| Metabolism | Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. | Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. | Cell Host Microbe | 10.1016/j.chom.2012.05.017 | 2012 | |
| A novel flow cytometric assay for measurement of in vivo pulmonary neutrophil phagocytosis. | Vander Top EA, Perry GA, Gentry-Nielsen MJ. | BMC Microbiol | 10.1186/1471-2180-6-61 | 2006 | | |
| Characterization of recombinant fluoroquinolone-resistant pneumococcus-like isolates. | Balsalobre L, Ortega M, de la Campa AG. | Antimicrob Agents Chemother | 10.1128/aac.01357-12 | 2013 | | |
| Pathogenicity | Genetic characterization of optochin-susceptible viridans group streptococci. | Martin-Galiano AJ, Balsalobre L, Fenoll A, de la Campa AG. | Antimicrob Agents Chemother | 10.1128/aac.47.10.3187-3194.2003 | 2003 | |
| Enzymology | Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection. | Izumikawa K, Akamatsu S, Kageyama A, Okada K, Kazuyama Y, Takayanagi N, Nakamura S, Inoue Y, Higashiyama Y, Fukushima K, Ishida T, Sawai T, Yoshimura K, Nakahama C, Ohmichi M, Kakugawa T, Nishioka Y, Aoki N, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S. | Clin Vaccine Immunol | 10.1128/cvi.00308-08 | 2009 | |
| Enzymology | Efficacy of a swab transport system in maintaining viability of Neisseria gonorrhoeae and Streptococcus pneumoniae. | Farhat SE, Thibault M, Devlin R. | J Clin Microbiol | 10.1128/jcm.39.8.2958-2960.2001 | 2001 | |
| Pathogenicity | Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. | Phipps JC, Aronoff DM, Curtis JL, Goel D, O'Brien E, Mancuso P. | Infect Immun | 10.1128/iai.00963-09 | 2010 | |
| Pathogenicity | Mefloquine and new related compounds target the F(0) complex of the F(0)F(1) H(+)-ATPase of Streptococcus pneumoniae. | Martin-Galiano AJ, Gorgojo B, Kunin CM, de la Campa AG. | Antimicrob Agents Chemother | 10.1128/aac.46.6.1680-1687.2002 | 2002 | |
| Pathogenicity | Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. | Berry V, Thorburn CE, Knott SJ, Woodnutt G. | Antimicrob Agents Chemother | 10.1128/aac.42.12.3193 | 1998 | |
| Pathogenicity | Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia. | van den Boogaard FE, van 't Veer C, Roelofs JJ, Meijers JC, Schultz MJ, Broze GJ, van der Poll T. | Thromb Haemost | 10.1160/th14-12-1053 | 2015 | |
| Combination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in mice. | Oliveira ML, Miyaji EN, Ferreira DM, Moreno AT, Ferreira PC, Lima FA, Santos FL, Sakauchi MA, Takata CS, Higashi HG, Raw I, Kubrusly FS, Ho PL. | PLoS One | 10.1371/journal.pone.0010863 | 2010 | | |
| Filamentous influenza A virus infection predisposes mice to fatal septicemia following superinfection with Streptococcus pneumoniae serotype 3. | Speshock JL, Doyon-Reale N, Rabah R, Neely MN, Roberts PC. | Infect Immun | 10.1128/iai.01943-06 | 2007 | | |
| Metabolism | Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. | Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. | PLoS One | 10.1371/journal.pone.0109072 | 2014 | |
| Enzymology | Rapid identification of clinically relevant Enterococcus species by fluorescence in situ hybridization. | Wellinghausen N, Bartel M, Essig A, Poppert S. | J Clin Microbiol | 10.1128/jcm.00861-07 | 2007 | |
| Metabolism | Streptococcus pneumoniae PstS production is phosphate responsive and enhanced during growth in the murine peritoneal cavity. | Orihuela CJ, Mills J, Robb CW, Wilson CJ, Watson DA, Niesel DW. | Infect Immun | 10.1128/iai.69.12.7565-7571.2001 | 2001 | |
| Pathogenicity | Antimicrobial activities of mefloquine and a series of related compounds. | Kunin CM, Ellis WY. | Antimicrob Agents Chemother | 10.1128/aac.44.4.848-852.2000 | 2000 | |
| Formation of Streptococcus pneumoniae non-phase-variable colony variants is due to increased mutation frequency present under biofilm growth conditions. | Allegrucci M, Sauer K. | J Bacteriol | 10.1128/jb.00707-08 | 2008 | | |
| Metabolism | The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen. | Lammers AJ, de Porto AP, de Boer OJ, Florquin S, van der Poll T. | BMC Infect Dis | 10.1186/1471-2334-12-139 | 2012 | |
| Pathogenicity | Effect and mechanism of calpains on pediatric lobar pneumonia. | Yin G, Zeng Q, Zhao H, Wu P, Cai S, Deng L, Jiang W. | Bioengineered | 10.1080/21655979.2016.1234544 | 2017 | |
| Comparative in vitro activity of ABT-773, a novel antibacterial ketolide. | Nilius AM, Bui MH, Almer L, Hensey-Rudloff D, Beyer J, Ma Z, Or YS, Flamm RK. | Antimicrob Agents Chemother | 10.1128/aac.45.7.2163-2168.2001 | 2001 | | |
| Novel murine model of pneumococcal pneumonia: use of temperature as a measure of disease severity to compare the efficacies of moxifloxacin and levofloxacin. | Bast DJ, Yue M, Chen X, Bell D, Dresser L, Saskin R, Mandell LA, Low DE, de Azavedo JC. | Antimicrob Agents Chemother | 10.1128/aac.48.9.3343-3348.2004 | 2004 | | |
| Phylogeny | Invasive pneumococcal disease in healthy adults: increase of empyema associated with the clonal-type Sweden(1)-ST306. | Grau I, Ardanuy C, Calatayud L, Rolo D, Rolo D, Domenech A, Linares J, Pallares R. | PLoS One | 10.1371/journal.pone.0042595 | 2012 | |
| Role of Nucleotide-Binding Oligomerization Domain-Containing (NOD) 2 in Host Defense during Pneumococcal Pneumonia. | Hommes TJ, van Lieshout MH, van 't Veer C, Florquin S, Bootsma HJ, Hermans PW, de Vos AF, van der Poll T. | PLoS One | 10.1371/journal.pone.0145138 | 2015 | | |
| Phylogeny | Genetic diversity of PspA types among nasopharyngeal isolates collected during an ongoing surveillance study of children in Brazil. | Pimenta FC, Ribeiro-Dias F, Brandileone MC, Miyaji EN, Leite LC, Sgambatti de Andrade AL. | J Clin Microbiol | 10.1128/jcm.00156-06 | 2006 | |
| Metabolism | Mechanisms of the hepatic acute-phase response during bacterial pneumonia. | Quinton LJ, Jones MR, Robson BE, Mizgerd JP. | Infect Immun | 10.1128/iai.01300-08 | 2009 | |
| Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study. | Schouten M, van't Veer C, Roelofs JJ, Levi M, van der Poll T. | Crit Care | 10.1186/cc11910 | 2012 | | |
| Pathogenicity | In vitro activities of oral beta-lactams at concentrations achieved in humans against penicillin-susceptible and -resistant pneumococci and potential to select resistance. | Thorburn CE, Knott SJ, Edwards DI. | Antimicrob Agents Chemother | 10.1128/aac.42.8.1973 | 1998 | |
| Enzymology | Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris. | Pettit GR, Knight JC, Herald DL, Pettit RK, Hogan F, Mukku VJ, Hamblin JS, Dodson MJ, Chapuis JC. | J Nat Prod | 10.1021/np800603u | 2009 | |
| Pathogenicity | Dysregulation of macrophage activation profiles by engineered nanoparticles. | Kodali V, Littke MH, Tilton SC, Teeguarden JG, Shi L, Frevert CW, Wang W, Pounds JG, Thrall BD. | ACS Nano | 10.1021/nn402145t | 2013 | |
| Immunization with pneumococcal polysaccharide serotype 3 and lipopolysaccharide modulates lung and liver inflammation during a virulent Streptococcus pneumoniae infection in mice. | Restori KH, Kennett MJ, Ross AC. | Clin Vaccine Immunol | 10.1128/cvi.00593-12 | 2013 | | |
| Systemic analysis of PPARgamma in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. | Gautier EL, Chow A, Spanbroek R, Marcelin G, Greter M, Jakubzick C, Bogunovic M, Leboeuf M, van Rooijen N, Habenicht AJ, Merad M, Randolph GJ. | J Immunol | 10.4049/jimmunol.1200495 | 2012 | | |
| Metabolism | L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. | Deady LE, Todd EM, Davis CG, Zhou JY, Topcagic N, Edelson BT, Ferkol TW, Cooper MA, Muenzer JT, Morley SC. | Infect Immun | 10.1128/iai.01199-13 | 2014 | |
| Molecular characterization of disease-associated streptococci of the mitis group that are optochin susceptible. | Balsalobre L, Hernandez-Madrid A, Llull D, Martin-Galiano AJ, Garcia E, Fenoll A, de la Campa AG. | J Clin Microbiol | 10.1128/jcm.01137-06 | 2006 | | |
| Epidemiology of invasive pneumococcal disease in older people in Spain (2007-2009): implications for future vaccination strategies. | Ardanuy C, Marimon JM, Calatayud L, Gimenez M, Alonso M, Grau I, Pallares R, Perez-Trallero E, Linares J. | PLoS One | 10.1371/journal.pone.0043619 | 2012 | | |
| Pathogenicity | Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae. | Ip M, Chau SS, Chi F, Tang J, Chan PK. | Antimicrob Agents Chemother | 10.1128/aac.00258-07 | 2007 | |
| Metabolism | Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2. | Zang QS, Martinez B, Yao X, Maass DL, Ma L, Wolf SE, Minei JP. | PLoS One | 10.1371/journal.pone.0043424 | 2012 | |
| Metabolism | A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales. | Wang C, Pulli B, Jalali Motlagh N, Li A, Wojtkiewicz GR, Schmidt SP, Wu Y, Zeller MWG, Chen JW. | Theranostics | 10.7150/thno.36264 | 2019 | |
| Metabolism | A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. | Veninga H, Hoek RM, de Vos AF, de Bruin AM, An FQ, van der Poll T, van Lier RA, Medof ME, Hamann J. | PLoS One | 10.1371/journal.pone.0024431 | 2011 | |
| The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. | Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminanthan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. | Nat Immunol | 10.1038/ni.3046 | 2015 | | |
| Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection. | Beshara R, Sencio V, Soulard D, Barthelemy A, Fontaine J, Pinteau T, Deruyter L, Ismail MB, Paget C, Sirard JC, Trottein F, Faveeuw C. | PLoS Pathog | 10.1371/journal.ppat.1007360 | 2018 | | |
| Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria. | Tian X, Xu F, Lung WY, Meyerson C, Ghaffari AA, Cheng G, Deng JC. | PLoS One | 10.1371/journal.pone.0041879 | 2012 | | |
| Metabolism | Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status. | Aslami H, Pulskens WP, Kuipers MT, Bos AP, van Kuilenburg AB, Wanders RJ, Roelofsen J, Roelofs JJ, Kerindongo RP, Beurskens CJ, Schultz MJ, Kulik W, Weber NC, Juffermans NP. | PLoS One | 10.1371/journal.pone.0063497 | 2013 | |
| Pathogenicity | Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. | Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S. | Infect Immun | 10.1128/iai.00914-09 | 2010 | |
| Phylogeny | Denaturing gradient gel electrophoresis of PCR-amplified gki genes: a new technique for tracking streptococci. | van Vliet MJ, Tissing WJ, de Bont ES, Meessen NE, Kamps WA, Harmsen HJ. | J Clin Microbiol | 10.1128/jcm.00089-09 | 2009 | |
| Pathogenicity | Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex. | Hakansson AP, Roche-Hakansson H, Mossberg AK, Svanborg C. | PLoS One | 10.1371/journal.pone.0017717 | 2011 | |
| PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models. | Hai R, Schmolke M, Varga ZT, Manicassamy B, Wang TT, Belser JA, Pearce MB, Garcia-Sastre A, Tumpey TM, Palese P. | J Virol | 10.1128/jvi.02717-09 | 2010 | | |
| Pathogenicity | A new antibiotic kills pathogens without detectable resistance. | Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schaberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. | Nature | 10.1038/nature14098 | 2015 | |
| A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy. | Abedini E, Khodadadi E, Zeinalzadeh E, Moaddab SR, Asgharzadeh M, Mehramouz B, Dao S, Samadi Kafil H. | Evid Based Complement Alternat Med | 10.1155/2021/8866311 | 2021 | | |
| Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. | Seetharamsingh B, Ramesh R, Dange SS, Khairnar PV, Singhal S, Upadhyay D, Veeraraghavan S, Viswanadha S, Vakkalanka S, Reddy DS. | ACS Med Chem Lett | 10.1021/acsmedchemlett.5b00213 | 2015 | | |
| Phylogeny | Serotyping Streptococcus pneumoniae by multiplex PCR. | Brito DA, Ramirez M, de Lencastre H. | J Clin Microbiol | 10.1128/jcm.41.6.2378-2384.2003 | 2003 | |
| Metabolism | The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. | Sharif O, Gawish R, Warszawska JM, Martins R, Lakovits K, Hladik A, Doninger B, Brunner J, Korosec A, Schwarzenbacher RE, Berg T, Kralovics R, Colinge J, Mesteri I, Gilfillan S, Salmaggi A, Verschoor A, Colonna M, Knapp S. | PLoS Pathog | 10.1371/journal.ppat.1004167 | 2014 | |
| Naturally-Sourced Antibacterial Polymeric Nanomaterials with Special Reference to Modified Polymer Variants. | Rofeal M, Abdelmalek F, Steinbuchel A. | Int J Mol Sci | 10.3390/ijms23084101 | 2022 | | |
| Metabolism | CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections. | Nguyen QT, Nguyen TH, Ju SA, Lee YS, Han SH, Lee SC, Kwon BS, Yu R, Kim GY, Lee BJ, Kim BS. | Infect Immun | 10.1128/iai.00115-13 | 2013 | |
| Metabolism | New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae. | Garcia MT, Blazquez MA, Ferrandiz MJ, Sanz MJ, Silva-Martin N, Hermoso JA, de la Campa AG. | J Biol Chem | 10.1074/jbc.m110.148148 | 2011 | |
| Phylogeny | Single-molecule long-read 16S sequencing to characterize the lung microbiome from mechanically ventilated patients with suspected pneumonia. | Toma I, Siegel MO, Keiser J, Yakovleva A, Kim A, Davenport L, Devaney J, Hoffman EP, Alsubail R, Crandall KA, Castro-Nallar E, Perez-Losada M, Hilton SK, Chawla LS, McCaffrey TA, Simon GL. | J Clin Microbiol | 10.1128/jcm.01678-14 | 2014 | |
| Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone. | Pozzi G, Masala L, Iannelli F, Manganelli R, Havarstein LS, Piccoli L, Simon D, Morrison DA. | J Bacteriol | 10.1128/jb.178.20.6087-6090.1996 | 1996 | | |
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| Pathogenicity | Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. | Gootz TD, Zaniewski R, Haskell S, Schmieder B, Tankovic J, Girard D, Courvalin P, Polzer RJ. | Antimicrob Agents Chemother | 10.1128/aac.40.12.2691 | 1996 | |
| Pathogenicity | Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response. | Vorderstrasse BA, Lawrence BP. | Infect Immun | 10.1128/iai.00837-06 | 2006 | |
| Pathogenicity | Failure of Micro Media FOX Microdilution System to detect decreased susceptibility of Streptococcus pneumoniae to penicillin. | Carroll K, Cohen S, Saxon B, Hamilton L. | J Clin Microbiol | 10.1128/jcm.29.11.2651-2652.1991 | 1991 | |
| Pathogenicity | Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae. | Vander Top EA, Wyatt TA, Gentry-Nielsen MJ. | Alcohol Clin Exp Res | 10.1097/01.alc.0000164364.35682.86 | 2005 | |
| Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis. | Wang L, Quan J, Johnston WE, Maass DL, Horton JW, Thomas JA, Tao W. | Burns | 10.1016/j.burns.2009.02.019 | 2010 | | |
| Metabolism | Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli. | Todd EM, Zhou JY, Szasz TP, Deady LE, D'Angelo JA, Cheung MD, Kim AH, Morley SC. | Blood | 10.1182/blood-2016-03-705962 | 2016 | |
| Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. | Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M. | Infect Immun | 10.1128/iai.01323-09 | 2010 | | |
| Pathogenicity | Serotype and genotype replacement among macrolide-resistant invasive Pneumococci in adults: mechanisms of resistance and association with different transposons. | Calatayud L, Ardanuy C, Tubau F, Rolo D, Rolo D, Grau I, Pallares R, Martin R, Linares J. | J Clin Microbiol | 10.1128/jcm.01868-09 | 2010 | |
| Efficacy of opsonic and nonopsonic serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibodies against intranasal challenge with Streptococcus pneumoniae in mice. | Tian H, Weber S, Thorkildson P, Kozel TR, Pirofski LA. | Infect Immun | 10.1128/iai.01075-08 | 2009 | | |
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| Enzymology | Duplex DNA-Invading gamma-Modified Peptide Nucleic Acids Enable Rapid Identification of Bloodstream Infections in Whole Blood. | Nolling J, Rapireddy S, Amburg JI, Crawford EM, Prakash RA, Rabson AR, Tang YW, Singer A. | mBio | 10.1128/mbio.00345-16 | 2016 | |
| Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci. | Chang Q, Zhong Z, Lees A, Pekna M, Pirofski L. | Infect Immun | 10.1128/iai.70.9.4977-4986.2002 | 2002 | | |
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| Phylogeny | Serotype 5 pneumococci causing invasive pneumococcal disease outbreaks in Barcelona, Spain (1997 to 2011). | Rolo D, Fenoll A, Fontanals D, Larrosa N, Gimenez M, Grau I, Pallares R, Linares J, Ardanuy C, Serotype 5 Study Group. | J Clin Microbiol | 10.1128/jcm.01538-13 | 2013 | |
| Metabolism | Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. | Cao J, Wang D, Xu F, Gong Y, Wang H, Song Z, Li D, Zhang H, Li D, Zhang L, Xia Y, Xu H, Lai X, Lin S, Zhang X, Ren G, Dai Y, Yin Y. | EMBO Mol Med | 10.1002/emmm.201302890 | 2014 | |
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| In vitro activity of cefepime against multidrug-resistant Gram-negative bacilli, viridans group streptococci and Streptococcus pneumoniae from a cross-Canada surveillance study. | Low DE, de Azavedo J, Canadian Bacterial Surveillance Network, Davidson R. | Can J Infect Dis | 10.1155/1999/172031 | 1999 | | |
| High doses of cefotaxime in treatment of adult meningitis due to Streptococcus pneumoniae with decreased susceptibilities to broad-spectrum cephalosporins. | Viladrich PF, Cabellos C, Pallares R, Tubau F, Martinez-Lacasa J, Linares J, Gudiol F. | Antimicrob Agents Chemother | 10.1128/aac.40.1.218 | 1996 | | |
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| Feasibility of radioimmunotherapy of experimental pneumococcal infection. | Dadachova E, Burns T, Bryan RA, Apostolidis C, Brechbiel MW, Nosanchuk JD, Casadevall A, Pirofski L. | Antimicrob Agents Chemother | 10.1128/aac.48.5.1624-1629.2004 | 2004 | | |
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| Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. | Branger J, Knapp S, Weijer S, Leemans JC, Pater JM, Speelman P, Florquin S, van der Poll T. | Infect Immun | 10.1128/iai.72.2.788-794.2004 | 2004 | | |
| Interruption of capsule production in Streptococcus pneumonia serotype 3 by insertion of transposon Tn916. | Watson DA, Musher DM. | Infect Immun | 10.1128/iai.58.9.3135-3138.1990 | 1990 | | |
| Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. | Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC. | J Clin Invest | 10.1172/jci35412 | 2009 | | |
| In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. | Nilius AM, Shen LL, Hensey-Rudloff D, Almer LS, Beyer JM, Balli DJ, Cai Y, Flamm RK. | Antimicrob Agents Chemother | 10.1128/aac.47.10.3260-3269.2003 | 2003 | | |
| GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. | Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M. | Immunity | 10.1016/j.immuni.2012.03.027 | 2012 | | |
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| Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. | Warszawska JM, Gawish R, Sharif O, Sigel S, Doninger B, Lakovits K, Mesteri I, Nairz M, Boon L, Spiel A, Fuhrmann V, Strobl B, Muller M, Schenk P, Weiss G, Knapp S. | J Clin Invest | 10.1172/jci67911 | 2013 | | |
| Pathogenicity | Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. | Capobianco JO, Cao Z, Shortridge VD, Ma Z, Flamm RK, Zhong P. | Antimicrob Agents Chemother | 10.1128/aac.44.6.1562-1567.2000 | 2000 | |
| Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia. | Blok DC, van der Sluijs KF, Florquin S, de Boer OJ, van 't Veer C, de Vos AF, van der Poll T. | PLoS One | 10.1371/journal.pone.0058191 | 2013 | | |
| Pathogenicity | Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins. | Dupuis M, Leclercq R. | Antimicrob Agents Chemother | 10.1128/aac.50.1.237-242.2006 | 2006 | |
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| Enzymology | Pharmacodynamic activity and efficacy of linezolid in a rat model of pneumococcal pneumonia. | Gentry-Nielsen MJ, Olsen KM, Preheim LC. | Antimicrob Agents Chemother | 10.1128/aac.46.5.1345-1351.2002 | 2002 | |
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| Attenuating Neurogenic Sympathetic Hyperreflexia Robustly Improves Antibacterial Immunity After Chronic Spinal Cord Injury. | Mironets E, Fischer R, Bracchi-Ricard V, Saltos TM, Truglio TS, O'Reilly ML, Swanson KA, Bethea JR, Tom VJ. | J Neurosci | 10.1523/jneurosci.2417-19.2019 | 2020 | | |
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| Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. | Jakobsen H, Schulz D, Pizza M, Rappuoli R, Jonsdottir I. | Infect Immun | 10.1128/iai.67.11.5892-5897.1999 | 1999 | | |
| Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. | Pettit GR, Tan R, Pettit RK, Smith TH, Feng S, Doubek DL, Richert L, Hamblin J, Weber C, Chapuis JC. | J Nat Prod | 10.1021/np068072c | 2007 | | |
| Metabolism | Fas/Fas ligand system mediates epithelial injury, but not pulmonary host defenses, in response to inhaled bacteria. | Matute-Bello G, Frevert CW, Liles WC, Nakamura M, Ruzinski JT, Ballman K, Wong VA, Vathanaprida C, Martin TR. | Infect Immun | 10.1128/iai.69.9.5768-5776.2001 | 2001 | |
| Evidence for horizontal gene transfer in evolution of elongation factor Tu in enterococci. | Ke D, Boissinot M, Huletsky A, Picard FJ, Frenette J, Ouellette M, Roy PH, Bergeron MG. | J Bacteriol | 10.1128/jb.182.24.6913-6920.2000 | 2000 | | |
| A human monoclonal immunoglobulin M reduces bacteremia and inflammation in a mouse model of systemic pneumococcal infection. | Fabrizio K, Groner A, Boes M, Pirofski LA. | Clin Vaccine Immunol | 10.1128/cvi.00374-06 | 2007 | | |
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| Hypertonic saline dextran after burn injury decreases inflammatory cytokine responses to subsequent pneumonia-related sepsis. | Horton JW, Maass DL, White DJ. | Am J Physiol Heart Circ Physiol | 10.1152/ajpheart.00586.2005 | 2006 | | |
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| Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections. | Jakobsen H, Saeland E, Gizurarson S, Schulz D, Jonsdottir I. | Infect Immun | 10.1128/iai.67.8.4128-4133.1999 | 1999 | | |
| Efficacies of ABT-773, a new ketolide, against experimental bacterial infections. | Mitten MJ, Meulbroek J, Nukkala M, Paige L, Jarvis K, Oleksijew A, Tovcimak A, Hernandez L, Alder JD, Ewing P, Or YS, Ma Z, Nilius AM, Mollison K, Flamm RK. | Antimicrob Agents Chemother | 10.1128/aac.45.9.2585-2593.2001 | 2001 | | |
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| Metabolism | Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling. | Zhou B, Liu J, Zeng L, Zhu S, Wang H, Billiar TR, Kroemer G, Klionsky DJ, Zeh HJ, Jiang J, Tang D, Kang R. | Nat Microbiol | 10.1038/s41564-020-00795-7 | 2020 | |
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| Pathogenicity | A novel ketolide, RBx 14255, with activity against multidrug-resistant Streptococcus pneumoniae. | Raj VS, Barman TK, Kalia V, Purnapatre K, Dube S, G R, Bhateja P, Mathur T, Chaira T, Upadhyay DJ, Surase YB, Venkataramanan R, Chakrabarti A, Das B, Bhatnagar PK | Antimicrob Agents Chemother | 10.1128/AAC.01589-13 | 2014 | |
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How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive14747.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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