Streptococcus pneumoniae D 39 is a facultative anaerobe, Gram-positive, coccus-shaped bacterium of the family Streptococcaceae.
Gram-positive coccus-shaped facultative anaerobe genome sequence 16S sequence Bacteria| @ref 20215 |
Last LPSN update
2026-02-09 11:32:38 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Lactobacillales |
| Family Streptococcaceae |
| Genus Streptococcus |
| Species Streptococcus pneumoniae |
| Full scientific name Streptococcus pneumoniae (Klein 1884) Chester 1901 (Approved Lists 1980) |
| Synonyms (2) |
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 93.4 |
| @ref | Salt | Growth | Tested relation | Concentration | |
|---|---|---|---|---|---|
| 35786 | NaCl | growth | 6.5 % |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | - | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | + | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | - | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 35786 | 4853 ChEBI | esculin | + | hydrolysis | |
| 68371 | 4853 ChEBI | esculin | - | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | - | builds acid from | from API 50CH acid |
| 35786 | 606565 ChEBI | hippurate | - | hydrolysis | |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | + | builds acid from | from API 50CH acid |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 28053 ChEBI | melibiose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | - | builds acid from | from API 50CH acid |
| 35786 | 17632 ChEBI | nitrate | - | reduction | |
| 35786 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | - | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | - | builds acid from | from API 50CH acid |
| 68371 | 17992 ChEBI | sucrose | + | builds acid from | from API 50CH acid |
| 68371 | 27082 ChEBI | trehalose | - | builds acid from | from API 50CH acid |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | - | 3.1.3.2 | from API zym |
| 35786 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | + | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | + | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 35786 | beta-galactosidase | + | 3.2.1.23 | |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 35786 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 35786 | gamma-glutamyltransferase | - | 2.3.2.2 | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 35786 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | - | from API zym | |
| 35786 | ornithine decarboxylase | - | 4.1.1.17 | |
| 35786 | oxidase | - | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68382 | valine arylamidase | + | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 35786 | not determinedn.d. | +/- | - | - | - | - | - | - | - | - | +/- | + | + | +/- | - | - | - | - | - | - | - | - | - | +/- | - | - | - | - | + | +/- | - | + | - | - | - | +/- | - | - | - | - | +/- | - | - | - | - | - | - | - | - | +/- |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 124043 | ASM1436v2 assembly for Streptococcus pneumoniae D39 | complete | GCA_000014365   | 373153.27  | 639633061  | 373153 | 99.44 | |
| 66792 | 43721_E02 assembly for Streptococcus pneumoniae NCTC7466 | complete | GCA_900475305 | 1313.15900 | 2860972970 | 1313 | 99.34 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. | Cao W, Xu D, Yu H, Shen X. | Microbiol Spectr | 10.1128/spectrum.01221-25 | 2025 | | |
| Antibiotic resistance and factors associated with colonization dynamics of Staphylococcus aureus and Streptococcus pneumoniae in healthy children in Lima, Peru. | Li Valverde VM, Aguirre Castaneda PC, Gonzales BE, Castillo-Tokumori F, Vidal JE, Ochoa TJ. | Epidemiol Infect | 10.1017/s0950268825100277 | 2025 | | |
| Early detection of bacterial pneumonia by characteristic induced odor signatures. | Arnold K, Gomez-Mejia A, de Figueiredo M, Boccard J, Singh KD, Rudaz S, Sinues P, Zinkernagel AS. | BMC Infect Dis | 10.1186/s12879-024-10371-7 | 2024 | | |
| Genetics | PneumoBrowse 2: an integrated visual platform for curated genome annotation and multiomics data analysis of Streptococcus pneumoniae. | Janssen AB, Gibson PS, Bravo AM, de Bakker V, Slager J, Veening JW. | Nucleic Acids Res | 10.1093/nar/gkae923 | 2025 | |
| In vitro antibacterial activity of dinuclear thiolato-bridged ruthenium(II)-arene compounds. | Bugnon Q, Melendez C, Desiatkina O, Fayolles de Chaptes L, Holzer I, Paunescu E, Hilty M, Furrer J. | Microbiol Spectr | 10.1128/spectrum.00954-23 | 2023 | | |
| Therapeutic potential of kaempferol on Streptococcus pneumoniae infection. | Xu L, Fang J, Ou D, Xu J, Deng X, Chi G, Feng H, Wang J. | Microbes Infect | 10.1016/j.micinf.2022.105058 | 2023 | | |
| Enhancing explainable SARS-CoV-2 vaccine development leveraging bee colony optimised Bi-LSTM, Bi-GRU models and bioinformatic analysis. | Ozsahin DU, Ameen ZS, Hassan AS, Mubarak AS. | Sci Rep | 10.1038/s41598-024-55762-7 | 2024 | | |
| New Streptomyces-Derived Antibacterial Compounds Targeting Gram-Positive Bacteria: A Systematic Review. | Ait Assou S, El Hassouni M. | ScientificWorldJournal | 10.1155/tswj/6659874 | 2025 | | |
| Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis. | Dyckhoff-Shen S, Masouris I, Islam H, Hammerschmidt S, Angele B, Marathe V, Buer J, Volk S, Pfister HW, Klein M, Koedel U, Kirschning CJ. | JCI Insight | 10.1172/jci.insight.165737 | 2024 | | |
| Hydrogen peroxide is responsible for the cytotoxic effects of Streptococcus pneumoniae on primary microglia in the absence of pneumolysin. | Jennert F, Schaaf D, Nau R, Kohler TP, Hammerschmidt S, Hausler D, Valentin-Weigand P, Seele J. | J Innate Immun | 10.1159/000536514 | 2024 | | |
| GpsB Coordinates StkP Signaling as a PASTA Kinase Adaptor in Streptococcus pneumoniae Cell Division. | Stauberova V, Kubesa B, Joseph M, Benedet M, Furlan B, Buriankova K, Ulrych A, Kupcik R, Vomastek T, Massidda O, Tsui HT, Winkler ME, Branny P, Doubravova L. | J Mol Biol | 10.1016/j.jmb.2024.168797 | 2024 | | |
| Wogonin attenuates the pathogenicity of Streptococcus pneumoniae by double-target inhibition of Pneumolysin and Sortase A. | Gu K, Ding L, Wang Z, Sun Y, Sun X, Yang W, Sun H, Tian Y, Wang Z, Sun L. | J Cell Mol Med | 10.1111/jcmm.17684 | 2023 | | |
| Antimicrobial Susceptibility Pattern and Serotype Distribution of Streptococcus pneumoniae Isolates From a Hospital-Based Study in Chandigarh, North India. | Sharma S, Sharma M, Ray P, Chakraborti A. | Cureus | 10.7759/cureus.21437 | 2022 | | |
| Corilagin: A Novel Antivirulence Strategy to Alleviate Streptococcus pneumoniae Infection by Diminishing Pneumolysin Oligomers. | Sheng Q, Hou X, Wang N, Liu M, Zhu H, Deng X, Liang X, Chi G. | Molecules | 10.3390/molecules27165063 | 2022 | | |
| AMP-Coated TiO2 Doped ZnO Nanomaterials Enhanced Antimicrobial Activity and Efficacy in Otitis Media Treatment by Elevating Hydroxyl Radical Levels. | Bai Q, Zhang Y, Cai R, Wu H, Fu H, Zhou X, Chai J, Teng X, Liu T. | Int J Nanomedicine | 10.2147/ijn.s449888 | 2024 | | |
| IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells. | Zhang Y, Gao S, Yao S, Weng D, Wang Y, Huang Q, Zhang X, Wang H, Xu W. | iScience | 10.1016/j.isci.2023.107464 | 2023 | | |
| Pathogenicity | Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges. | Audshasai T, Coles JA, Panagiotou S, Khandaker S, Scales HE, Kjos M, Baltazar M, Vignau J, Brewer JM, Kadioglu A, Yang M. | mBio | 10.1128/mbio.01024-22 | 2022 | |
| Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae. | Barkowsky G, Abt C, Pohner I, Bieda A, Hammerschmidt S, Jacob A, Kreikemeyer B, Patenge N. | Microbiol Spectr | 10.1128/spectrum.00497-22 | 2022 | | |
| The association between serum complement C3a and severity in patients with community-acquired pneumonia. | Xu Z, Hou XF, Feng CM, Zheng L, Xu DX, Zhao H, Fu L. | Front Immunol | 10.3389/fimmu.2023.1034233 | 2023 | | |
| Enzymology | A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. | Shearer HL, Pace PE, Paton JC, Hampton MB, Dickerhof N. | J Biol Chem | 10.1016/j.jbc.2022.102359 | 2022 | |
| hsdSA regulated extracellular vesicle-associated PLY to protect Streptococcus pneumoniae from macrophage killing via LAPosomes. | Wang L, Liu M, Qi Y, Wang J, Shi Q, Xie X, Zhou C, Ma L. | Microbiol Spectr | 10.1128/spectrum.00995-23 | 2024 | | |
| A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness. | Lenhard A, Joma BH, Siwapornchai N, Hakansson AP, Leong JM, Bou Ghanem EN. | J Vis Exp | 10.3791/64419 | 2022 | | |
| Antibiotic Tolerance Indicative of Persistence Is Pervasive among Clinical Streptococcus pneumoniae Isolates and Shows Strong Condition Dependence. | Geerts N, De Vooght L, Passaris I, Delputte P, Van den Bergh B, Cos P. | Microbiol Spectr | 10.1128/spectrum.02701-22 | 2022 | | |
| Increased Pulmonary Pneumococcal Clearance after Resolution of H9N2 Avian Influenza Virus Infection in Mice. | Li J, Wang H, Lian P, Bai Y, Zhang Z, Zhao L, Xu T, Qiao J. | Infect Immun | 10.1128/iai.00062-21 | 2021 | | |
| Transcriptome | Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39. | Slager J, Aprianto R, Veening JW. | Nucleic Acids Res | 10.1093/nar/gky725 | 2018 | |
| Proteomic Adaptation of Streptococcus pneumoniae to the Antimicrobial Peptide Human Beta Defensin 3 (hBD3) in Comparison to Other Cell Surface Stresses. | Mucke PA, Ostrzinski A, Hammerschmidt S, Maass S, Becher D. | Microorganisms | 10.3390/microorganisms8111697 | 2020 | | |
| Pathogenicity | Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling. | de Groot RCA, Zhu H, Hoogenboezem T, de Bruijn ACJM, Eenjes E, 't Jong AEJ, Belo AI, Estevao SC, Bajramovic JJ, Rottier RJ, Kool M, van Rossum AMC, Unger WWJ. | Infect Immun | 10.1128/iai.00129-22 | 2022 | |
| Genetics | Comparative Metabolic Pathways Analysis and Subtractive Genomics Profiling to Prioritize Potential Drug Targets Against Streptococcus pneumoniae. | Khan K, Jalal K, Khan A, Al-Harrasi A, Uddin R. | Front Microbiol | 10.3389/fmicb.2021.796363 | 2021 | |
| Enzymology | Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease. | Law AE, Shears RK, Lopez Rodas AA, Grencis RK, Cooper PJ, Neill DR, Kadioglu A. | Sci Rep | 10.1038/s41598-021-86508-4 | 2021 | |
| Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors. | Oehmcke-Hecht S, Maletzki C, Surabhi S, Siemens N, Khaimov V, John LM, Peter SM, Hammerschmidt S, Kreikemeyer B. | J Innate Immun | 10.1159/000525479 | 2023 | | |
| Cortex Cercis chinensis Granules Attenuate Streptococcus pneumoniae Virulence by Targeting Pneumolysin. | Xu Y, Wang Y, Guo Y, Wei L, Ding L, Wang Z, Sun L. | Evid Based Complement Alternat Med | 10.1155/2020/8537026 | 2020 | | |
| Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone "6,7,4'-Trimethyl Flavone" Isolated from Wulfenia amherstiana. | Kakar M, Kakar M, Amin MU, Alghamdi S, Sahibzada MUK, Ahmad N, Ullah N. | Evid Based Complement Alternat Med | 10.1155/2020/3903682 | 2020 | | |
| Resistance of Streptococcus pneumoniae to Hypothiocyanous Acid Generated by Host Peroxidases. | Shearer HL, Kaldor CD, Hua H, Kettle AJ, Parker HA, Hampton MB. | Infect Immun | 10.1128/iai.00530-21 | 2022 | | |
| Underground railway particulate matter and susceptibility to pneumococcal infection. | Miyashita L, Shears R, Foley G, Semple S, Kadioglu A, Grigg J. | EBioMedicine | 10.1016/j.ebiom.2022.104063 | 2022 | | |
| Metabolism | Site-Specific Mutations of GalR Affect Galactose Metabolism in Streptococcus pneumoniae. | McLean KT, Tikhomirova A, Brazel EB, Legendre S, Haasbroek G, Minhas V, Paton JC, Trappetti C. | J Bacteriol | 10.1128/jb.00180-20 | 2020 | |
| Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor. | Sharma M, Sharma S, Ray P, Chakraborti A. | Drug Target Insights | 10.33393/dti.2020.2103 | 2020 | | |
| Pathogenicity | Urban Particles Elevated Streptococcus pneumoniae Biofilms, Colonization of the Human Middle Ear Epithelial Cells, Mouse Nasopharynx and Transit to the Middle Ear and Lungs. | Yadav MK, Go YY, Jun I, Chae SW, Song JJ. | Sci Rep | 10.1038/s41598-020-62846-7 | 2020 | |
| Pathogenicity | Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner. | Shu Z, Yuan J, Wang H, Zhang J, Li S, Zhang H, Liu Y, Yin Y, Zhang X. | Virulence | 10.1080/21505594.2020.1739411 | 2020 | |
| Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022. | Kaur K, Sharma R, Singh A, Attri S, Arora S, Kaur S, Bedi N. | Chin Herb Med | 10.1016/j.chmed.2022.08.001 | 2022 | | |
| Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection. | Zhang X, Cui J, Wu Y, Wang H, Wang J, Qiu Y, Mo Y, He Y, Zhang X, Yin Y, Xu W. | Front Immunol | 10.3389/fimmu.2017.01983 | 2017 | | |
| Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example. | Sun L, Wang D, Xu Y, Qi W, Wang Y. | Evid Based Complement Alternat Med | 10.1155/2020/8873371 | 2020 | | |
| A Triple-challenge Mouse Model of Allergic Airway Disease, Primary Influenza Infection, and Secondary Bacterial Infection. | Roberts S, Williams CM, Roy S, Furuya Y. | Bio Protoc | 10.21769/bioprotoc.3583 | 2020 | | |
| The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. | Fernandes VE, Ercoli G, Benard A, Brandl C, Fahnenstiel H, Muller-Winkler J, Weber GF, Denny P, Nitschke L, Andrew PW. | PLoS Pathog | 10.1371/journal.ppat.1008464 | 2020 | | |
| Proteomic Adaptation of Streptococcus pneumoniae to the Human Antimicrobial Peptide LL-37. | Mucke PA, Maass S, Kohler TP, Hammerschmidt S, Becher D. | Microorganisms | 10.3390/microorganisms8030413 | 2020 | | |
| Metabolism | Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infection. | Gonzalez LA, Melo-Gonzalez F, Sebastian VP, Vallejos OP, Noguera LP, Suazo ID, Schultz BM, Manosalva AH, Penaloza HF, Soto JA, Parker D, Riedel CA, Gonzalez PA, Kalergis AM, Bueno SM. | Front Immunol | 10.3389/fimmu.2021.638917 | 2021 | |
| Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells. | Gao Y, Xu W, Dou X, Wang H, Zhang X, Yang S, Liao H, Hu X, Wang H. | Front Microbiol | 10.3389/fmicb.2019.00630 | 2019 | | |
| Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation. | Lentini G, Fama A, De Gaetano GV, Coppolino F, Mahjoub AK, Ryan L, Lien E, Espevik T, Beninati C, Teti G. | Cell Rep Med | 10.1016/j.xcrm.2023.101098 | 2023 | | |
| Mucosal immunization with the live attenuated vaccine SPY1 induces humoral and Th2-Th17-regulatory T cell cellular immunity and protects against pneumococcal infection. | Xu X, Wang H, Liu Y, Wang Y, Zeng L, Wu K, Wang J, Ma F, Xu W, Yin Y, Zhang X. | Infect Immun | 10.1128/iai.02334-14 | 2015 | | |
| Metabolism | The MpsAB Bicarbonate Transporter Is Superior to Carbonic Anhydrase in Biofilm-Forming Bacteria with Limited CO2 Diffusion. | Fan SH, Matsuo M, Huang L, Tribelli PM, Gotz F. | Microbiol Spectr | 10.1128/spectrum.00305-21 | 2021 | |
| Disruption of the cpsE and endA Genes Attenuates Streptococcus pneumoniae Virulence: Towards the Development of a Live Attenuated Vaccine Candidate. | Amonov M, Simbak N, Wan Hassan WMR, Ismail S, A Rahman NI, Clarke SC, Yeo CC. | Vaccines (Basel) | 10.3390/vaccines8020187 | 2020 | | |
| Metabolism | Mechanism of Macrolide-Induced Inhibition of Pneumolysin Release Involves Impairment of Autolysin Release in Macrolide-Resistant Streptococcus pneumoniae. | Domon H, Maekawa T, Yonezawa D, Nagai K, Oda M, Yanagihara K, Terao Y. | Antimicrob Agents Chemother | 10.1128/aac.00161-18 | 2018 | |
| Pathogenicity | Pneumococcal Colonization and Virulence Factors Identified Via Experimental Evolution in Infection Models. | Green AE, Howarth D, Chaguza C, Echlin H, Langendonk RF, Munro C, Barton TE, Hinton JCD, Bentley SD, Rosch JW, Neill DR. | Mol Biol Evol | 10.1093/molbev/msab018 | 2021 | |
| Synthetic Analogs of Streptococcus pneumoniae Capsular Polysaccharides and Immunogenic Activities of Glycoconjugates. | Gening ML, Kurbatova EA, Nifantiev NE. | Russ J Bioorg Chem | 10.1134/s1068162021010076 | 2021 | | |
| Metabolism | The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface. | Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ. | Infect Immun | 10.1128/iai.00742-18 | 2019 | |
| Metabolism | The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection. | Yadav MK, Vidal JE, Go YY, Kim SH, Chae SW, Song JJ. | Front Cell Infect Microbiol | 10.3389/fcimb.2018.00138 | 2018 | |
| Metabolism | TLR4 deficiency reduces pulmonary resistance to Streptococcus pneumoniae in gut microbiota-disrupted mice. | Wang H, Lian P, Niu X, Zhao L, Mu X, Feng B, Li J, Liang Z, Qiao J. | PLoS One | 10.1371/journal.pone.0209183 | 2018 | |
| Research Progress on the Antibacterial Activity of Natural Flavonoids. | Zhang Z, Cao M, Shang Z, Xu J, Chen X, Zhu Z, Wang W, Wei X, Zhou X, Bai Y, Zhang J. | Antibiotics (Basel) | 10.3390/antibiotics14040334 | 2025 | | |
| Novel Virulence Role of Pneumococcal NanA in Host Inflammation and Cell Death Through the Activation of Inflammasome and the Caspase Pathway. | Tseng YW, Chang CC, Chang YC. | Front Cell Infect Microbiol | 10.3389/fcimb.2021.613195 | 2021 | | |
| Metabolism | Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y2 internalization in alveolar epithelial cells. | Olotu C, Lehmensiek F, Koch B, Kiefmann M, Riegel AK, Hammerschmidt S, Kiefmann R. | J Biol Chem | 10.1074/jbc.ra118.007236 | 2019 | |
| The Tyrosine-Autokinase UbK Is Required for Proper Cell Growth and Cell Morphology of Streptococcus pneumoniae. | Pelletier A, Freton C, Gallay C, Trouve J, Cluzel C, Franz-Wachtel M, Macek B, Jault JM, Grangeasse C, Guiral S. | Front Microbiol | 10.3389/fmicb.2019.01942 | 2019 | | |
| Pathogenicity | Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A. | Song M, Teng Z, Li M, Niu X, Wang J, Deng X. | J Cell Mol Med | 10.1111/jcmm.13179 | 2017 | |
| Enzymology | Novel molecular method for identification of Streptococcus pneumoniae applicable to clinical microbiology and 16S rRNA sequence-based microbiome studies. | Scholz CF, Poulsen K, Kilian M. | J Clin Microbiol | 10.1128/jcm.00365-12 | 2012 | |
| Metabolism | Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages. | Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. | Am J Respir Crit Care Med | 10.1164/rccm.201608-1714oc | 2017 | |
| Metabolism | The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract. | Kung E, Coward WR, Neill DR, Malak HA, Muhlemann K, Kadioglu A, Hilty M, Hathaway LJ. | PLoS One | 10.1371/journal.pone.0092355 | 2014 | |
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| Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes. | Bricio-Moreno L, Chaguza C, Yahya R, Shears RK, Cornick JE, Hokamp K, Yang M, Neill DR, French N, Hinton JCD, Everett DB, Kadioglu A. | mBio | 10.1128/mbio.00814-20 | 2020 | | |
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| Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota. | Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber AD, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J. | Front Immunol | 10.3389/fimmu.2019.02106 | 2019 | | |
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| Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. | Shears RK, Jacques LC, Naylor G, Miyashita L, Khandaker S, Lebre F, Lavelle EC, Grigg J, French N, Neill DR, Kadioglu A. | J Allergy Clin Immunol | 10.1016/j.jaci.2019.11.039 | 2020 | | |
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| PCV7- and PCV10-Vaccinated Otitis-Prone Children in New Zealand Have Similar Pneumococcal and Haemophilus influenzae Densities in Their Nasopharynx and Middle Ear. | de Gier C, Granland CM, Pickering JL, Walls T, Bhuiyan M, Mills N, Richmond PC, Best EJ, Thornton RB, Kirkham LS. | Vaccines (Basel) | 10.3390/vaccines7010014 | 2019 | | |
| Enzymology | A novel extracellular vesicle-associated endodeoxyribonuclease helps Streptococcus pneumoniae evade neutrophil extracellular traps and is required for full virulence. | Jhelum H, Sori H, Sehgal D. | Sci Rep | 10.1038/s41598-018-25865-z | 2018 | |
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| In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis. | Schmidt F, Kakar N, Meyer TC, Depke M, Masouris I, Burchhardt G, Gomez-Mejia A, Dhople V, Havarstein LS, Sun Z, Moritz RL, Volker U, Koedel U, Hammerschmidt S. | PLoS Pathog | 10.1371/journal.ppat.1007987 | 2019 | | |
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| Metabolism | Protective Regulatory T Cell Immune Response Induced by Intranasal Immunization With the Live-Attenuated Pneumococcal Vaccine SPY1 via the Transforming Growth Factor-beta1-Smad2/3 Pathway. | Liao H, Peng X, Gan L, Feng J, Gao Y, Yang S, Hu X, Zhang L, Yin Y, Wang H, Xu X. | Front Immunol | 10.3389/fimmu.2018.01754 | 2018 | |
| Metabolism | Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence. | Trappetti C, McAllister LJ, Chen A, Wang H, Paton AW, Oggioni MR, McDevitt CA, Paton JC. | mBio | 10.1128/mbio.02269-16 | 2017 | |
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| Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use. | Ramuta TZ, Sket T, Starcic Erjavec M, Kreft ME. | Front Bioeng Biotechnol | 10.3389/fbioe.2021.691522 | 2021 | | |
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| A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation. | Das S, Bernasconi E, Koutsokera A, Wurlod DA, Tripathi V, Bonilla-Rosso G, Aubert JD, Derkenne MF, Mercier L, Pattaroni C, Rapin A, von Garnier C, Marsland BJ, Engel P, Nicod LP. | Nat Commun | 10.1038/s41467-021-22344-4 | 2021 | | |
| Metabolism | Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae infection. | Fang R, Hara H, Sakai S, Hernandez-Cuellar E, Mitsuyama M, Kawamura I, Tsuchiya K. | Infect Immun | 10.1128/iai.01572-14 | 2014 | |
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| Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung. | Mouraux S, Bernasconi E, Pattaroni C, Koutsokera A, Aubert JD, Claustre J, Pison C, Royer PJ, Magnan A, Kessler R, Benden C, Soccal PM, Marsland BJ, Nicod LP, SysCLAD Consortium. | J Allergy Clin Immunol | 10.1016/j.jaci.2017.06.022 | 2018 | | |
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BacDive in 2025: the core database for prokaryotic strain data
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