Helicobacter hepaticus Hh-2 is a microaerophile, Gram-negative, motile animal pathogen that was isolated from liver of a mouse with active, chronic hepatitis.
Gram-negative motile rod-shaped microaerophile animal pathogen 16S sequence Bacteria| @ref 20215 |
Last LPSN update
2026-05-29 08:26:19 |
| Domain Bacteria |
| Phylum Pseudomonadota |
| Class Epsilonproteobacteria |
| Order Campylobacterales |
| Family Helicobacteraceae |
| Genus Helicobacter |
| Species Helicobacter hepaticus |
| Full scientific name Helicobacter hepaticus Fox et al. 1994 |
| Synonyms (1) |
| BacDive ID | Other strains from Helicobacter hepaticus (3) | Type strain |
|---|---|---|
| 134450 | H. hepaticus 3B1/Hh1, CIP 104102, ATCC 51449, CCUG 44777 | |
| 138977 | H. hepaticus Hh3, CIP 104101, ATCC 51450, CCUG 44776 | |
| 148150 | H. hepaticus CCUG 34904, NCTC 12886 |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 16616 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive  | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 119878 | CIP Medium 45 | Medium recipe at CIP |
| @ref | Salt | Growth | Tested relation | Concentration | |
|---|---|---|---|---|---|
| 119878 | NaCl | growth | 3.5 % |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68373 | 16947 ChEBI | citrate | - | assimilation | from API CAM |
| 68373 | 17632 ChEBI | nitrate | + | reduction | from API CAM |
| 119878 | 17632 ChEBI | nitrate | + | reduction | |
| 119878 | 16301 ChEBI | nitrite | - | reduction | |
| 68373 | 17272 ChEBI | propionate | - | assimilation | from API CAM |
| 68373 | 16199 ChEBI | urea | + | hydrolysis | from API CAM |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | - | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 119878 | catalase | + | 1.11.1.6 | |
| 68373 | catalase | + | 1.11.1.6 | from API CAM |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 119878 | DNase | - | ||
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 119878 | gamma-glutamyltransferase | - | 2.3.2.2 | |
| 68373 | gamma-glutamyltransferase | - | 2.3.2.2 | from API CAM |
| 119878 | gelatinase | - | ||
| 68373 | L-aspartate arylamidase | - | 3.4.11.21 | from API CAM |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 119878 | oxidase | + | ||
| 68373 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API CAM |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 119878 | urease | + | 3.5.1.5 | |
| 68373 | urease | + | 3.5.1.5 | from API CAM |
| 68382 | valine arylamidase | - | from API zym |
Metadata FA analysis  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| @ref | 51649 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| @ref | URE | Reduction of nitrateNIT | EsteraseEST | HIP | GGT | TTC | PYRA | L-arginine arylamidaseArgA | L-aspartic acid arylamidaseAspA | PAL | H2S productionH2S | GLU | SUT | NAL | CFZ | ACE | PROP | MLT | CIT | Erythromycin resistance (+) sensitivity (-)ERO | CAT | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16616 | + | + | - | + | - | + | - | - | - | + | - | - | - | - | - | - | - | - | - | - | + | |
| 16616 | + | + | - | - | - | - | - | - | - | +/- | - | - | - | - | - | + | - | - | - | - | + | |
| 16616 | + | + | - | - | - | - | - | - | - | + | - | + | + | - | + | - | - | + | - | + | + | |
| 16616 | + | + | + | + | - | + | - | +/- | - | + | - | - | - | - | - | - | - | - | - | - | + |
| Cat1 | Cat2 | Cat3 | |
|---|---|---|---|
| #Infection | #Inflammation | - | |
| #Host | #Mammals | #Muridae (Mouse/Rat) | |
| #Host Body-Site | #Organ | #Liver |
| @ref | Sample type | Geographic location | Country | Country ISO 3 Code | Continent | Isolation date | |
|---|---|---|---|---|---|---|---|
| 16616 | liver of a mouse with active, chronic hepatitis | Massachusetts | USA | USA | North America | ||
| 51649 | Mouse liver | Massachusetts | USA | USA | North America | ||
| 119878 | Animal, Mouse, liver | Cambridge, Massachusetts | United States of America | USA | North America | 1993 |
Global distribution of 16S sequence U07574 (>99% sequence identity) for Helicobacter hepaticus subclade from Microbeatlas 
 Aquatic Samples |
139 |
 Soil Samples |
127 |
 Animal Samples |
11680 |
 Plant Samples |
36 |
| Total Samples | 11982 |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. | Friedrich V, Forne I, Matzek D, Ring D, Popper B, Jochum L, Spriewald S, Straub T, Imhof A, Krug A, Stecher B, Brocker T. | Gut Microbes | 10.1080/19490976.2021.1882928 | 2021 | | |
| Cytokines derived from innate lymphoid cells assist Helicobacter hepaticus to aggravate hepatocellular tumorigenesis in viral transgenic mice. | Han X, Huang T, Han J. | Gut Pathog | 10.1186/s13099-019-0302-0 | 2019 | | |
| Pathogenicity | Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis. | Barron MR, Sovacool KL, Abernathy-Close L, Vendrov KC, Standke AK, Bergin IL, Schloss PD, Young VB. | mBio | 10.1128/mbio.01904-22 | 2022 | |
| Metabolism | Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease. | Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T. | Cell Rep Med | 10.1016/j.xcrm.2021.100381 | 2021 | |
| Phylogeny | Diagnosis of Genus Helicobacter through a hemi-nested PCR assay of 16S rRNA. | Qin H, Tang G, Yi P, Pan X, Huang H, Chang R, Shi Z, Ashraf MA. | Saudi Pharm J | 10.1016/j.jsps.2016.04.015 | 2016 | |
| Enzymology | Evaluation of a Novel Stool Antigen Rapid Test Kit for Detection of Helicobacter pylori Infection. | Kakiuchi T, Okuda M, Hashiguchi K, Imamura I, Nakayama A, Matsuo M. | J Clin Microbiol | 10.1128/jcm.01825-18 | 2019 | |
| Enzymology | Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease. | Hamada T, Yokota K, Ayada K, Hirai K, Kamada T, Haruma K, Chayama K, Oguma K. | Helicobacter | 10.1111/j.1523-5378.2009.00729.x | 2009 | |
| Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. | Ge Z, Sterzenbach T, Whary MT, Rickman BH, Rogers AB, Shen Z, Taylor NS, Schauer DB, Josenhans C, Suerbaum S, Fox JG. | Microbes Infect | 10.1016/j.micinf.2008.03.011 | 2008 | | |
| Enzymology | Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus. | Ge Z, White DA, Whary MT, Fox JG. | J Clin Microbiol | 10.1128/jcm.39.7.2598-2602.2001 | 2001 | |
| Phylogeny | Use of pulsed-field gel electrophoresis to determine genomic diversity in strains of Helicobacter hepaticus from geographically distant locations. | Saunders KE, McGovern KJ, Fox JG. | J Clin Microbiol | 10.1128/jcm.35.11.2859-2863.1997 | 1997 | |
| Natural history of Helicobacter hepaticus infection in conventional A/J mice, with special reference to liver involvement. | Avenaud P, Le Bail B, Mayo K, Marais A, Fawaz R, Bioulac-Sage P, Megraud F. | Infect Immun | 10.1128/iai.71.6.3667-3672.2003 | 2003 | | |
| In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. | Young VB, Knox KA, Pratt JS, Cortez JS, Mansfield LS, Rogers AB, Fox JG, Schauer DB. | Infect Immun | 10.1128/iai.72.5.2521-2527.2004 | 2004 | | |
| Enzymology | Detection of Helicobacter colonization of the murine lower bowel by genus-specific PCR-denaturing gradient gel electrophoresis. | Grehan M, Tamotia G, Robertson B, Mitchell H. | Appl Environ Microbiol | 10.1128/aem.68.10.5164-5166.2002 | 2002 | |
| Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. | Cahill RJ, Foltz CJ, Fox JG, Dangler CA, Powrie F, Schauer DB. | Infect Immun | 10.1128/iai.65.8.3126-3131.1997 | 1997 | | |
| Production and application of new monoclonal antibodies specific for a fecal Helicobacter pylori antigen. | Suzuki N, Wakasugi M, Nakaya S, Okada K, Mochida R, Sato M, Kajiyama H, Takahashi R, Hirata H, Ezure Y, Koga Y, Fukuda Y, Shimoyama T. | Clin Diagn Lab Immunol | 10.1128/cdli.9.1.75-78.2002 | 2002 | | |
| Enzymology | Catalase, a specific antigen in the feces of human subjects infected with Helicobacter pylori. | Suzuki N, Wakasugi M, Nakaya S, Kokubo N, Sato M, Kajiyama H, Takahashi R, Hirata H, Ezure Y, Fukuda Y, Shimoyama T. | Clin Diagn Lab Immunol | 10.1128/cdli.9.4.784-788.2002 | 2002 | |
| Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. | Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani BM, Zeng W, Nicks A, Tsang M, Shows D, Morrissey P, Viney JL. | Am J Pathol | 10.1016/s0002-9440(10)62489-3 | 2005 | | |
| Chronic active hepatitis induced by Helicobacter hepaticus in the A/JCr mouse is associated with a Th1 cell-mediated immune response. | Whary MT, Morgan TJ, Dangler CA, Gaudes KJ, Taylor NS, Fox JG. | Infect Immun | 10.1128/iai.66.7.3142-3148.1998 | 1998 | | |
| Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. | Fox JG, Yan L, Shames B, Campbell J, Murphy JC, Li X. | Infect Immun | 10.1128/iai.64.9.3673-3681.1996 | 1996 | | |
| Phylogeny | Detection of Helicobacter pylori in gastric mucosa of patients with gastroduodenal diseases by PCR-restriction analysis using the RNA polymerase gene (rpoB). | Lim CY, Lee KH, Cho MJ, Chang MW, Kim SY, Myong NH, Lee WK, Rhee KH, Kook YH. | J Clin Microbiol | 10.1128/jcm.41.7.3387-3391.2003 | 2003 | |
| Phylogeny | Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. | Rocha M, Avenaud P, Menard A, Le Bail B, Balabaud C, Bioulac-Sage P, de Magalhaes Queiroz DM, Megraud F. | Gut | 10.1136/gut.2004.042168 | 2005 | |
| Recombinant Helicobacter bilis protein P167 for mouse serodiagnosis in a multiplex microbead assay. | Feng S, Kendall LV, Hodzic E, Wong S, Lorenzana E, Freet K, Ku KS, Luciw PA, Barthold SW, Khan IH. | Clin Diagn Lab Immunol | 10.1128/cdli.11.6.1094-1099.2004 | 2004 | | |
| Phylogeny | Development of a real-time fluorescence resonance energy transfer PCR to detect arcobacter species. | Abdelbaqi K, Buissonniere A, Prouzet-Mauleon V, Gresser J, Wesley I, Megraud F, Menard A. | J Clin Microbiol | 10.1128/jcm.00256-07 | 2007 | |
| Nod2 is required for the regulation of commensal microbiota in the intestine. | Petnicki-Ocwieja T, Hrncir T, Liu YJ, Biswas A, Hudcovic T, Tlaskalova-Hogenova H, Kobayashi KS. | Proc Natl Acad Sci U S A | 10.1073/pnas.0907722106 | 2009 | | |
| Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma. | Kruttgen A, Horz HP, Weber-Heynemann J, Vucur M, Trautwein C, Haase G, Luedde T, Roderburg C. | Gut Microbes | 10.4161/gmic.19922 | 2012 | | |
| Metabolism | Glycoconjugate binding of gastric and enterohepatic Helicobacter spp. | Hynes SO, Teneberg S, Roche N, Wadstrom T. | Infect Immun | 10.1128/iai.71.5.2976-2980.2003 | 2003 | |
| Immune responses to bile-tolerant helicobacter species in patients with chronic liver diseases, a randomized population group, and healthy blood donors. | Ananieva O, Nilsson I, Vorobjova T, Uibo R, Wadstrom T. | Clin Diagn Lab Immunol | 10.1128/cdli.9.6.1160-1164.2002 | 2002 | | |
| Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients. | Nilsson HO, Stenram U, Ihse I, Wadstrom T. | World J Gastroenterol | 10.3748/wjg.v12.i19.3038 | 2006 | | |
| Enzymology | Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis. | Nilsson HO, Taneera J, Castedal M, Glatz E, Olsson R, Wadstrom T. | J Clin Microbiol | 10.1128/jcm.38.3.1072-1076.2000 | 2000 | |
| Pathogenicity | Simultaneous identification of campylobacters and prediction of quinolone resistance by comparative sequence analysis. | Husmann M, Feddersen A, Steitz A, Freytag C, Bhakdi S. | J Clin Microbiol | 10.1128/jcm.35.9.2398-2400.1997 | 1997 | |
| Pathogenicity | Evaluation of antibiotic treatment against "Candidatus Helicobacter suis" in a mouse model. | Hellemans A, Decostere A, Haesebrouck F, Ducatelle R. | Antimicrob Agents Chemother | 10.1128/aac.49.11.4530-4535.2005 | 2005 | |
| Identification of the major antigenic protein of Helicobacter cinaedi and its immunogenicity in humans with H. cinaedi infections. | Iwashita H, Fujii S, Kawamura Y, Okamoto T, Sawa T, Masaki T, Nishizono A, Higashi S, Kitamura T, Tamura F, Sasaki Y, Akaike T. | Clin Vaccine Immunol | 10.1128/cvi.00439-07 | 2008 | | |
| Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. | Dieleman LA, Arends A, Tonkonogy SL, Goerres MS, Craft DW, Grenther W, Sellon RK, Balish E, Sartor RB | Infect Immun | 10.1128/IAI.68.9.5107-5113.2000 | 2000 | | |
| Pathogenicity | Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease. | Nilsson I, Lindgren S, Eriksson S, Wadstrom T | Gut | 10.1136/gut.46.3.410 | 2000 | |
| Enzymology | Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. | Fox JG, Dewhirst FE, Tully JG, Paster BJ, Yan L, Taylor NS, Collins MJ, Gorelick PL, Ward JM. | J Clin Microbiol | 10.1128/jcm.32.5.1238-1245.1994 | 1994 | |
| Phylogeny | Helicobacter mesocricetorum sp. nov., A novel Helicobacter isolated from the feces of Syrian hamsters. | Simmons JH, Riley LK, Besch-Williford CL, Franklin CL. | J Clin Microbiol | 10.1128/jcm.38.5.1811-1817.2000 | 2000 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive6105.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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