Name: Helicobacter hepaticus Hh-2
Creator: BacDive
License: https://creativecommons.org/licenses/by/4.0/

Strain identifier

BacDive ID: 6105

Type strain:

Species: Helicobacter hepaticus

Strain Designation: Hh-2, Hh2

Culture col. no.: DSM 22909, ATCC 51448, CCUG 33637, CIP 104100, LMG 16316

Strain history: CIP <- 1994, J.G. Fox, Technol. Inst., Cambridge, MA, USA: strain Hh2

NCBI tax ID(s): 32025 (species)

SI-ID 8880

LMG 16316, ATCC 51448, CCUG 33637, CIP 104100, BCRC 17336, CCRC 17336, DSM 22909

Special Collections

Other strains from Helicobacter hepaticus

Section

When using BacDive for research please cite our paper

Helicobacter hepaticus Hh-2 is a microaerophile, mesophilic, Gram-negative animal pathogen that was isolated from liver of a mouse with active, chronic hepatitis.

Gram-negative
motile
rod-shaped
animal pathogen
mesophilic
microaerophile
16S sequence
Bacteria

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	09-12-2024 (DD-MM-YYYY)
	Domain	*Bacteria*
	Phylum	*Pseudomonadota*
	Class	*Epsilonproteobacteria*
	Order	*Campylobacterales*
	Family	*Helicobacteraceae*
	Genus	*Helicobacter*
	Species	**Helicobacter hepaticus**
	Full Scientific Name (LPSN)	Helicobacter hepaticus Fox et al. 1994

Synonym

"Helicobacter hepaticus"

Information on morphological and physiological properties Morphology

[Ref.: #119878]	Gram stain	negative

[Ref.: #119878]	Cell shape	rod-shaped

[Ref.: #119878]	Motility	yes

[Ref.: #16616]

Incubation period

3-7 days

Information on culture and growth conditions Culture and growth conditions

[Ref.: #16616]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #16616]

Culture medium growth

[Ref.: #16616]

Culture medium link

Medium recipe at MediaDive

[Ref.: #16616]

Culture medium composition

expand / minimize

[Ref.: #119878]

Culture medium

CIP Medium 45

[Ref.: #119878]

Culture medium growth

[Ref.: #119878]

Culture medium link

Medium recipe provided by DSMZ

	Kind of temperature		Temperature
[Ref.: #16616]		growth	37 °C
[Ref.: #51649]		growth	37 °C
[Ref.: #119878]		growth	37 °C
[Ref.: #119878]	negative	growth	5 °C
[Ref.: #119878]	negative	growth	10 °C
[Ref.: #119878]	negative	growth	25 °C
[Ref.: #119878]	negative	growth	30 °C
[Ref.: #119878]	negative	growth	41 °C
[Ref.: #119878]	negative	growth	45 °C

Information on physiology and metabolism Physiology and metabolism

[Ref.: #51649]	Oxygen tolerance	microaerophile
[Ref.: #119878]	Oxygen tolerance	microaerophile

	Halophily	Salt	Tested relation		Salt conc.
[Ref.: #119878]		NaCl	no	growth	3.5	%

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68373]	citrate ChEBI	-	assimilation	* from API CAM
[Ref.: #119878]	nitrate ChEBI	+	reduction
[Ref.: #68373]	nitrate ChEBI	+	reduction	* from API CAM
[Ref.: #119878]	nitrite ChEBI	-	reduction
[Ref.: #68373]	propionate ChEBI	-	assimilation	* from API CAM
[Ref.: #68373]	urea ChEBI	+	hydrolysis	* from API CAM

	Antibiotica	Metabolite	Antibiotic sensitivity	Concentration		Antibiotic resistance
[Ref.: #119878]		0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)	no			yes
[Ref.: #68373]		nalidixic acid ChEBI	yes	84	µg		* from API CAM

	Metabolite production	Metabolite	Production
[Ref.: #119878]		indole ChEBI	no
[Ref.: #68373]		hydrogen sulfide ChEBI	no	* from API CAM

	Enzyme	Enzyme activity	EC number
[Ref.: #68382]	acid phosphatase	-	3.1.3.2	* from API zym
[Ref.: #68382]	alkaline phosphatase	-	3.1.3.1	* from API zym
[Ref.: #68382]	alpha-chymotrypsin	-	3.4.21.1	* from API zym
[Ref.: #68382]	alpha-fucosidase	-	3.2.1.51	* from API zym
[Ref.: #68382]	alpha-galactosidase	-	3.2.1.22	* from API zym
[Ref.: #68382]	alpha-glucosidase	-	3.2.1.20	* from API zym
[Ref.: #68382]	alpha-mannosidase	-	3.2.1.24	* from API zym
[Ref.: #68382]	beta-galactosidase	-	3.2.1.23	* from API zym
[Ref.: #68382]	beta-glucosidase	-	3.2.1.21	* from API zym
[Ref.: #68382]	beta-glucuronidase	-	3.2.1.31	* from API zym
[Ref.: #119878]	catalase	+	1.11.1.6
[Ref.: #68373]	catalase	+	1.11.1.6	* from API CAM
[Ref.: #68382]	cystine arylamidase	-	3.4.11.3	* from API zym
[Ref.: #119878]	DNase	-
[Ref.: #68382]	esterase (C 4)	+		* from API zym
[Ref.: #68382]	esterase lipase (C 8)	+		* from API zym
[Ref.: #119878]	gamma-glutamyltransferase	-	2.3.2.2
[Ref.: #68373]	gamma-glutamyltransferase	-	2.3.2.2	* from API CAM
[Ref.: #119878]	gelatinase	-
[Ref.: #68373]	L-aspartate arylamidase	-	3.4.11.21	* from API CAM
[Ref.: #68382]	leucine arylamidase	+	3.4.11.1	* from API zym
[Ref.: #68382]	lipase (C 14)	-		* from API zym
[Ref.: #68382]	N-acetyl-beta-glucosaminidase	-	3.2.1.52	* from API zym
[Ref.: #68382]	naphthol-AS-BI-phosphohydrolase	+		* from API zym
[Ref.: #119878]	oxidase	+
[Ref.: #68373]	pyrrolidonyl arylamidase	-	3.4.19.3	* from API CAM
[Ref.: #68382]	trypsin	-	3.4.21.4	* from API zym
[Ref.: #119878]	urease	+	3.5.1.5
[Ref.: #68373]	urease	+	3.5.1.5	* from API CAM
[Ref.: #68382]	valine arylamidase	-		* from API zym
	Only first 10 entries are displayed. Click here to see all.

Fatty acid profile

Metadata FA analysis

Reference

[Ref.: #51649]

Fatty acid	Percentage	ECL
C16:0	22	16
C18:1 ω7c /12t/9t	18.8	17.824
C16:0 3OH	13.5	17.52
C12:0	9.7	12
C14:0	8.8	14
C17:1 ω5c ISO	7.7	16.461
C12:0 3OH	3.7	13.455
unknown 14.966	2.6	14.966
C18:2 ω6,9c/C18:0 ANTE	2.1	17.724
C13:1 at 12-13	1.3	12.931
C15:0	1.2	15
unknown 12.486	1.2	12.486
C18:0	0.8	18
C13:0	0.7	13
Unidentified	0.7	17.257
C16:1 ω7c	0.7	15.819
C17:0	0.6	17
Unidentified	0.6	18.282
Unidentified	0.5	18.225
C18:1 ω9c	0.5	17.769
C14:0 3OH/C16:1 ISO I	0.5	15.485
C13:0 3OH/C15:1 i I/H	0.5	14.469
C16:1 ω7c alcohol	0.4	15.386
Unidentified	0.3	15.946
C17:1 ω6c	0.3	16.862
C17:1 ω7c	0.3	16.818
C17:0 iso 3OH	0.2	18.161

API® CAM:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Urease/urea hydrolysisURE	Reduction of nitrateNIT	EsteraseEST	Hippuric acidHIP	gamma-Glutamyl transferaseGGT	Reduction of Triphenyl tetrazolium chlorideTTC	Pyrrolidonyl arylamidasePYRA	L-arginine arylamidaseArgA	L-aspartic acid arylamidaseAspA	Alkaline phosphatasePAL	H2S productionH2S	Assimilation of D-glucoseGLU	Assimilation of succinateSUT	Growth inhibitionNAL	Growth inhibitionCFZ	Assimilation of acetateACE	Assimilation of propionic acidPROP	Assimilation of malic acidMLT	Assimilation of citric acidCIT	Erythromycin resistance (+) sensitivity (-)ERO	CatalaseCAT
[Ref.: #16616]	4251	+	+	-	+	-	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
[Ref.: #16616]	4129	+	+	-	-	-	-	-	-	-	+/-	-	-	-	-	-	+	-	-	-	-	+
[Ref.: #16616]	4128	+	+	-	-	-	-	-	-	-	+	-	+	+	-	+	-	-	+	-	+	+
[Ref.: #16616]	4308	+	+	+	+	-	+	-	+/-	-	+	-	-	-	-	-	-	-	-	-	-	+

API® zym:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Control	2-naphthyl phosphateAlkaline phosphatase	2-naphthyl butyrateEsterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	2-naphthyl myristateLipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	N-benzoyl-DL-arginine-2-naphthylamideTrypsin	N-glutaryl-phenylalanine-2-naphthylamidealpha- Chymotrypsin	2-naphthyl phosphateAcid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	6-Br-2-naphthyl-alphaD-galactpyranosidealpha- Galactosidase	2-naphthyl-betaD-galactpyranosidebeta- Galactosidase	Naphthol-AS-BI-betaD-glucuronidebeta- Glucuronidase	2-naphthyl-alphaD-glucopyranosidealpha- Glucosidase	6-Br-2-naphthyl-betaD-glucopyranosidebeta- Glucosidase	1-naphthyl-N-acetyl-betaD-glucosaminideN-acetyl-beta- glucosaminidase	6-Br-2-naphthyl-alphaD-mannopyranosidealpha- Mannosidase	2-naphthyl-alphaL-fucopyranosidealpha- Fucosidase
[Ref.: #119878]	7794	-	-	+	+	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #16616]	Sample type/isolated from	liver of a mouse with active, chronic hepatitis
[Ref.: #16616]	Geographic location (country and/or sea, region)	Massachusetts
[Ref.: #16616]	Country	USA
[Ref.: #16616]	Country ISO 3 Code	USA
[Ref.: #16616]	Continent	North America

[Ref.: #51649]	Sample type/isolated from	Mouse liver
[Ref.: #51649]	Geographic location (country and/or sea, region)	Massachusetts
[Ref.: #51649]	Country	USA
[Ref.: #51649]	Country ISO 3 Code	USA
[Ref.: #51649]	Continent	North America

[Ref.: #119878]	Sample type/isolated from	Animal, Mouse, liver
[Ref.: #119878]	Geographic location (country and/or sea, region)	Cambridge, Massachusetts
[Ref.: #119878]	Country	United States of America
[Ref.: #119878]	Country ISO 3 Code	USA
[Ref.: #119878]	Continent	North America
[Ref.: #119878]	Isolation date	1993
* marker position based on {}

Isolation sources categories

#Infection	#Inflammation	-
#Host	#Mammals	#Muridae (Mouse/Rat)
#Host Body-Site	#Organ	#Liver

What are isolation sources categories?

[Ref.: #69479]

Global distribution of 16S sequence U07574 (>99% sequence identity) for Helicobacter hepaticus subclade from Microbeatlas

Aquatic Samples	139
Soil Samples	127
Animal Samples	11680
Plant Samples	36
Total Samples	11982

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #16616]	Pathogenicity (animal)	yes
[Ref.: #16616]	Biosafety level	2	Risk group (German classification) According to TRBA 466
[Ref.: #119878]	Biosafety level	2	Risk group (French classification)

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #16616]	Helicobacter hepaticus strain Hh-2 16S ribosomal RNA gene, partial sequence	U07574	1470	GenBank ENA	32025 tax ID
[Ref.: #20218]	Helicobacter hepaticus 16S ribosomal RNA gene, partial sequence	AF302103	1445	GenBank ENA	32025 tax ID	*

Availability in culture collections External links

[Ref.: #16616]

Culture collection no.

DSM 22909, ATCC 51448, CCUG 33637, CIP 104100, LMG 16316

[Ref.: #75593]

SI-ID 8880

Literature:

	Title	Authors	Journal	DOI	Year
Pathogenicity	Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease.	Nilsson I, Lindgren S, Eriksson S, Wadstrom T	Gut	10.1136/gut.46.3.410	2000	*
	Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice.	Dieleman LA, Arends A, Tonkonogy SL, Goerres MS, Craft DW, Grenther W, Sellon RK, Balish E, Sartor RB	Infect Immun	10.1128/IAI.68.9.5107-5113.2000	2000	*

References

#16616

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 22909

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#51649 Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 33637

#68373

Automatically annotated from API CAM .

#68382

Automatically annotated from API zym .

#69479

João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .

#75593

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID8880.1 )

#119878 Collection of Institut Pasteur ; Curators of the CIP; CIP 104100
* These data were automatically processed and therefore are not curated

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