Strain identifier

BacDive ID: 6105

Type strain: Yes

Species: Helicobacter hepaticus

Strain Designation: Hh-2, Hh2

Strain history: CIP <- 1994, J.G. Fox, Technol. Inst., Cambridge, MA, USA: strain Hh2

NCBI tax ID(s): 32025 (species)

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General

@ref: 16616

BacDive-ID: 6105

DSM-Number: 22909

keywords: 16S sequence, Bacteria, microaerophile, mesophilic, Gram-negative, motile, rod-shaped, animal pathogen

description: Helicobacter hepaticus Hh-2 is a microaerophile, mesophilic, Gram-negative animal pathogen that was isolated from liver of a mouse with active, chronic hepatitis.

NCBI tax id

  • NCBI tax id: 32025
  • Matching level: species

strain history

@refhistory
16616<- CCUG <- ATCC <- J. G. Fox, Massachusetts Inst. Technology, Cambridge, USA; Hh-2 <- L. Yan
119878CIP <- 1994, J.G. Fox, Technol. Inst., Cambridge, MA, USA: strain Hh2

doi: 10.13145/bacdive6105.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/pseudomonadota
  • domain: Bacteria
  • phylum: Pseudomonadota
  • class: Epsilonproteobacteria
  • order: Campylobacterales
  • family: Helicobacteraceae
  • genus: Helicobacter
  • species: Helicobacter hepaticus
  • full scientific name: Helicobacter hepaticus Fox et al. 1994

  • synonyms

    • @ref: 20215
    • synonym: Helicobacter hepaticus

@ref: 16616

domain: Bacteria

phylum: Proteobacteria

class: Epsilonproteobacteria

order: Campylobacterales

family: Helicobacteraceae

genus: Helicobacter

species: Helicobacter hepaticus

full scientific name: Helicobacter hepaticus Fox et al. 1994

strain designation: Hh-2, Hh2

type strain: yes

Morphology

cell morphology

  • @ref: 119878
  • gram stain: negative
  • cell shape: rod-shaped
  • motility: yes

colony morphology

@refincubation period
166163-7 days
119878

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
16616COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yeshttps://mediadive.dsmz.de/medium/693Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
119878CIP Medium 45yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=45

culture temp

@refgrowthtypetemperaturerange
16616positivegrowth37mesophilic
51649positivegrowth37mesophilic
119878positivegrowth37mesophilic
119878nogrowth5psychrophilic
119878nogrowth10psychrophilic
119878nogrowth25mesophilic
119878nogrowth30mesophilic
119878nogrowth41thermophilic
119878nogrowth45thermophilic

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
51649microaerophile
119878microaerophile

halophily

  • @ref: 119878
  • salt: NaCl
  • growth: no
  • tested relation: growth
  • concentration: 3.5 %

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
11987817632nitrate+reduction
11987816301nitrite-reduction
6837316199urea+hydrolysis
6837317632nitrate+reduction
6837317272propionate-assimilation
6837316947citrate-assimilation

antibiotic resistance

@refChEBImetaboliteis antibioticis sensitivesensitivity conc.is resistant
68373100147nalidixic acidyesyes84 µg
1198780129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)yesnoyes

metabolite production

@refChebi-IDmetaboliteproduction
6837316136hydrogen sulfideno
11987835581indoleno

enzymes

@refvalueactivityec
68382alpha-fucosidase-3.2.1.51
68382alpha-mannosidase-3.2.1.24
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382beta-glucosidase-3.2.1.21
68382alpha-glucosidase-3.2.1.20
68382beta-glucuronidase-3.2.1.31
68382beta-galactosidase-3.2.1.23
68382alpha-galactosidase-3.2.1.22
68382naphthol-AS-BI-phosphohydrolase+
68382acid phosphatase-3.1.3.2
68382alpha-chymotrypsin-3.4.21.1
68382trypsin-3.4.21.4
68382cystine arylamidase-3.4.11.3
68382valine arylamidase-
68382leucine arylamidase+3.4.11.1
68382lipase (C 14)-
68382esterase lipase (C 8)+
68382esterase (C 4)+
68382alkaline phosphatase-3.1.3.1
68373catalase+1.11.1.6
68373L-aspartate arylamidase-3.4.11.21
68373pyrrolidonyl arylamidase-3.4.19.3
68373gamma-glutamyltransferase-2.3.2.2
68373urease+3.5.1.5
119878oxidase+
119878gelatinase-
119878DNase-
119878catalase+1.11.1.6
119878gamma-glutamyltransferase-2.3.2.2
119878urease+3.5.1.5

fatty acid profile

  • fatty acids

    @reffatty acidpercentageECL
    51649C12:09.712
    51649C13:00.713
    51649C14:08.814
    51649C15:01.215
    51649C16:02216
    51649C17:00.617
    51649C18:00.818
    51649C12:0 3OH3.713.455
    51649C13:0 3OH/C15:1 i I/H0.514.469
    51649C13:1 at 12-131.312.931
    51649C14:0 3OH/C16:1 ISO I0.515.485
    51649C16:0 3OH13.517.52
    51649C16:1 ω7c0.715.819
    51649C16:1 ω7c alcohol0.415.386
    51649C17:0 iso 3OH0.218.161
    51649C17:1 ω5c ISO7.716.461
    51649C17:1 ω6c0.316.862
    51649C17:1 ω7c0.316.818
    51649C18:1 ω7c /12t/9t18.817.824
    51649C18:1 ω9c0.517.769
    51649C18:2 ω6,9c/C18:0 ANTE2.117.724
    51649Unidentified0.315.946
    51649Unidentified0.717.257
    51649Unidentified0.518.225
    51649Unidentified0.618.282
    51649unknown 12.4861.212.486
    51649unknown 14.9662.614.966
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
119878--++-+-----+--------

API CAM

@refURENITESTHIPGGTTTCPYRAArgAAspAPALH2SGLUSUTNALCFZACEPROPMLTCITEROCAT
16616++-+-+---+----------+
16616++-------+/------+----+
16616++-------+-++-+--+-++
16616++++-+-+/--+----------+

Isolation, sampling and environmental information

isolation

@refsample typegeographic locationcountryorigin.countrycontinentisolation date
16616liver of a mouse with active, chronic hepatitisMassachusettsUSAUSANorth America
51649Mouse liverMassachusettsUSAUSANorth America
119878Animal, Mouse, liverCambridge, MassachusettsUnited States of AmericaUSANorth America1993

isolation source categories

Cat1Cat2Cat3
#Infection#Inflammation
#Host#Mammals#Muridae (Mouse/Rat)
#Host Body-Site#Organ#Liver

taxonmaps

  • @ref: 69479
  • File name: preview.99_5841.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_36;96_946;97_1292;98_4342;99_5841&stattab=map
  • Last taxonomy: Helicobacter hepaticus subclade
  • 16S sequence: U07574
  • Sequence Identity:
  • Total samples: 11982
  • soil counts: 127
  • aquatic counts: 139
  • animal counts: 11680
  • plant counts: 36

Safety information

risk assessment

@refpathogenicity animalbiosafety levelbiosafety level comment
16616yes2Risk group (German classification)
1198782Risk group (French classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Helicobacter hepaticus 16S ribosomal RNA gene, partial sequenceAF3021031445ena32025
16616Helicobacter hepaticus strain Hh-2 16S ribosomal RNA gene, partial sequenceU075741470ena32025

External links

@ref: 16616

culture collection no.: DSM 22909, ATCC 51448, CCUG 33637, CIP 104100, LMG 16316

straininfo link

  • @ref: 75593
  • straininfo: 8880

literature

topicPubmed-IDtitleauthorsjournalDOIyearmesh
Pathogenicity10673306Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease.Nilsson I, Lindgren S, Eriksson S, Wadstrom TGut10.1136/gut.46.3.4102000Adult, Aged, Aged, 80 and over, Antibodies, Bacterial/*blood, Case-Control Studies, Chronic Disease, Female, Helicobacter/*immunology, Helicobacter Infections/complications/*immunology, Helicobacter pylori/immunology, Humans, Immunoenzyme Techniques, Immunoglobulin E/blood, Immunoglobulin G/blood, Liver Diseases/immunology/*microbiology, Male, Middle Aged
10948132Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice.Dieleman LA, Arends A, Tonkonogy SL, Goerres MS, Craft DW, Grenther W, Sellon RK, Balish E, Sartor RBInfect Immun10.1128/IAI.68.9.5107-5113.20002000Animals, CD4-Positive T-Lymphocytes/immunology, Colitis/*etiology, Germ-Free Life, Helicobacter/*pathogenicity, Interleukin-10/deficiency/*physiology, Lymphocyte Activation, Mice, Mice, Inbred C57BL

Reference

@idauthorscataloguedoi/urltitlejournalpubmed
16616Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 22909)https://www.dsmz.de/collection/catalogue/details/culture/DSM-22909
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
20218Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.10.1016/j.syapm.2013.11.002StrainInfo introduces electronic passports for microorganisms.Syst Appl Microbiol. 37: 42-50 201424321274
51649Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 33637)https://www.ccug.se/strain?id=33637
68373Automatically annotated from API CAM
68382Automatically annotated from API zym
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
75593Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.10.60712/SI-ID8880.1StrainInfo: A central database for resolving microbial strain identifiers
119878Curators of the CIPCollection of Institut Pasteur (CIP 104100)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20104100