Corynebacterium diphtheriae 5159 is a bacterium that produces toxins.
toxin production genome sequence Bacteria
SI-ID 35897
| @ref 20215 |
Last LPSN update
2026-05-29 08:25:38 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Mycobacteriales |
| Family Corynebacteriaceae |
| Genus Corynebacterium |
| Species Corynebacterium diphtheriae |
| Full scientific name Corynebacterium diphtheriae (Kruse 1886) Lehmann and Neumann 1896 (Approved Lists 1980) |
| Synonyms (1) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 11439 | TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) | Medium recipe at MediaDive  | Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water | ||
| 11439 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base |
| @ref | Growth | Type | Temperature (°C) | |
|---|---|---|---|---|
| 11439 | positive | growth | 37 |
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | facultative anaerobe | 92.989 |
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 98.831 |
| 11439 | Compoundtoxin |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68379 | 17634 ChEBI | D-glucose | + | fermentation | from API Coryne |
| 68379 | 16899 ChEBI | D-mannitol | - | fermentation | from API Coryne |
| 68379 | 16988 ChEBI | D-ribose | + | fermentation | from API Coryne |
| 68379 | 65327 ChEBI | D-xylose | - | fermentation | from API Coryne |
| 68379 | 4853 ChEBI | esculin | - | hydrolysis | from API Coryne |
| 68379 | 5291 ChEBI | gelatin | - | hydrolysis | from API Coryne |
| 68379 | 28087 ChEBI | glycogen | - | fermentation | from API Coryne |
| 68379 | 17716 ChEBI | lactose | - | fermentation | from API Coryne |
| 68379 | 17306 ChEBI | maltose | + | fermentation | from API Coryne |
| 68379 | 17632 ChEBI | nitrate | + | reduction | from API Coryne |
| 68379 | 17992 ChEBI | sucrose | - | fermentation | from API Coryne |
| 68379 | 16199 ChEBI | urea | - | hydrolysis | from API Coryne |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68379 | alkaline phosphatase | - | 3.1.3.1 | from API Coryne |
| 68379 | alpha-glucosidase | - | 3.2.1.20 | from API Coryne |
| 68379 | beta-galactosidase | - | 3.2.1.23 | from API Coryne |
| 68379 | beta-glucosidase | - | 3.2.1.21 | from API Coryne |
| 68379 | beta-glucuronidase | - | 3.2.1.31 | from API Coryne |
| 68379 | catalase | + | 1.11.1.6 | from API Coryne |
| 68379 | gelatinase | - | from API Coryne | |
| 68379 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API Coryne |
| 68379 | pyrazinamidase | - | 3.5.1.B15 | from API Coryne |
| 68379 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API Coryne |
| 68379 | urease | - | 3.5.1.5 | from API Coryne |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | Corynebacterium diphtheriae strain FDAARGOS_1553 | complete | 1717.765  | 1717 | 99.51 | | ||
| 124043 | ASM2073610v1 assembly for Corynebacterium diphtheriae FDAARGOS_1553 | complete | GCA_020736105  | 1717.761 | 1717 | 97.83 | | |
| 66792 | CdipDSM43989 assembly for Corynebacterium diphtheriae DSM 43989 | contig | GCA_001913255 | 1717.286 | 8005185762  | 1717 | 69.63 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Metabolism | Human antibodies neutralizing diphtheria toxin in vitro and in vivo. | Wenzel EV, Bosnak M, Tierney R, Schubert M, Brown J, Dubel S, Efstratiou A, Sesardic D, Stickings P, Hust M. | Sci Rep | 10.1038/s41598-019-57103-5 | 2020 | |
| Effects of Antimicrobial Flavonoids Against Representative Bacteria and Fungi: A Review of the Literature. | Hamid ME, Alamri F, Abdelrahim IM, Joseph M, Elamin MM, Alraih AM. | Cureus | 10.7759/cureus.62765 | 2024 | | |
| Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR. | Rosana Y, Prilandari LI, Ajisman R, Hartono TS, Yasmon A. | Iran J Microbiol | 10.18502/ijm.v12i6.5024 | 2020 | | |
| Phylogeny | Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015. | du Plessis M, Wolter N, Allam M, de Gouveia L, Moosa F, Ntshoe G, Blumberg L, Cohen C, Smith M, Mutevedzi P, Thomas J, Horne V, Moodley P, Archary M, Mahabeer Y, Mahomed S, Kuhn W, Mlisana K, McCarthy K, von Gottberg A. | Emerg Infect Dis | 10.3201/eid2308.162039 | 2017 | |
| Genetics | Genome-wide comparison of Corynebacterium diphtheriae isolates from Australia identifies differences in the Pan-genomes between respiratory and cutaneous strains. | Timms VJ, Nguyen T, Crighton T, Yuen M, Sintchenko V. | BMC Genomics | 10.1186/s12864-018-5147-2 | 2018 | |
| Analysis of Corynebacterium diphtheriae macrophage interaction: Dispensability of corynomycolic acids for inhibition of phagolysosome maturation and identification of a new gene involved in synthesis of the corynomycolic acid layer. | Ott L, Hacker E, Kunert T, Karrington I, Etschel P, Lang R, Wiesmann V, Wittenberg T, Singh A, Varela C, Bhatt A, Sangal V, Burkovski A. | PLoS One | 10.1371/journal.pone.0180105 | 2017 | | |
| Enzymology | Characterization of Corynebacterium diphtheriae isolates from infected skin lesions in the Northern Territory of Australia. | Gordon CL, Fagan P, Hennessy J, Baird R. | J Clin Microbiol | 10.1128/jcm.05038-11 | 2011 | |
| Asclepain cI, a proteolytic enzyme from Asclepias curassavica L., a south American plant, against Helicobacter pylori. | Salinas Ibanez AG, Origone AL, Liggieri CS, Barberis SE, Vega AE. | Front Microbiol | 10.3389/fmicb.2022.961958 | 2022 | | |
| Enzymology | DNA nanodevices map enzymatic activity in organelles. | Dan K, Veetil AT, Chakraborty K, Krishnan Y. | Nat Nanotechnol | 10.1038/s41565-019-0365-6 | 2019 | |
| Phylogeny | Diphtheria in the Republic of Georgia: use of molecular typing techniques for characterization of Corynebacterium diphtheriae strains. | Sulakvelidze A, Kekelidze M, Gomelauri T, Deng Y, Khetsuriani N, Kobaidze K, De Zoysa A, Efstratiou A, Morris JG, Imnadze P. | J Clin Microbiol | 10.1128/jcm.37.10.3265-3270.1999 | 1999 | |
| Evaluation of antidiphtheria toxin nanobodies. | Shaker GH. | Nanotechnol Sci Appl | 10.2147/nsa.s9591 | 2010 | | |
| Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120. | Botello-Morte L, Pellicer S, Sein-Echaluce VC, Contreras LM, Neira JL, Abian O, Velazquez-Campoy A, Peleato ML, Fillat MF, Bes MT. | Antioxid Redox Signal | 10.1089/ars.2014.6175 | 2016 | | |
| Heterogeneity of diphtheria toxin gene, tox, and its regulatory element, dtxR, in Corynebacterium diphtheriae strains causing epidemic diphtheria in Russia and Ukraine. | Nakao H, Pruckler JM, Mazurova IK, Narvskaia OV, Glushkevich T, Marijevski VF, Kravetz AN, Fields BS, Wachsmuth IK, Popovic T. | J Clin Microbiol | 10.1128/jcm.34.7.1711-1716.1996 | 1996 | | |
| Metabolism | Rapid determination of Corynebacterium diphtheriae toxigenicity by counterimmunoelectrophoresis. | Thompson NL, Ellner PD. | J Clin Microbiol | 10.1128/jcm.7.5.493-494.1978 | 1978 | |
| Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals. | Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, Boshoff HI, Ulrich RL, Barry CE, Bartlett DH, Kravchenko VV, Kaufmann GF, Janda KD. | J Am Chem Soc | 10.1021/ja9056079 | 2009 | | |
| Pathogenicity | Of mice and men: Interaction of Corynebacterium diphtheriae strains with murine and human phagocytes. | Weerasekera D, Fastner T, Lang R, Burkovski A, Ott L | Virulence | 10.1080/21505594.2019.1614384 | 2019 | |
| Enzymology | The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress. | Hillion M, Imber M, Pedre B, Bernhardt J, Saleh M, Loi VV, Maass S, Becher D, Astolfi Rosado L, Adrian L, Weise C, Hell R, Wirtz M, Messens J, Antelmann H | Sci Rep | 10.1038/s41598-017-05206-2 | 2017 | |
| Metabolism | Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids. | Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R | Infect Immun | 10.1128/IAI.00075-17 | 2017 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive3152.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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