Name: Corynebacterium diphtheriae 5159
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 3152

Type strain:

Species: Corynebacterium diphtheriae

Strain Designation: 5159

Culture col. no.: DSM 43989, ATCC 13812

Strain history: <- ATCC <- J.M. Coffey, 5159 <- Mass. Antitoxin Lab., strain Park-Williams

NCBI tax ID(s): 1717 (species)

SI-ID 35897

ATCC 13812, DSM 43989, BCRC 10655, CCRC 10655

Other strains from Corynebacterium diphtheriae

Section

Corynebacterium diphtheriae 5159 is a mesophilic bacterium that produces toxins.

toxin production
mesophilic
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Mycobacteriales*
	Family	*Corynebacteriaceae*
	Genus	*Corynebacterium*
	Species	**Corynebacterium diphtheriae**
	Full Scientific Name (LPSN)	Corynebacterium diphtheriae (Kruse 1886) Lehmann and Neumann 1896 (Approved Lists 1980)

Synonym

"Bacillus diphtheriae"

Information on morphological and physiological properties Morphology

[Ref.: #69480]	Gram stain	positive Confidence in %100

[Ref.: #69480]	Motility	no Confidence in %95.329

Information on culture and growth conditions Culture and growth conditions

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Culture medium

TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

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Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #11439]			growth	37 °C

[Ref.: #11439]

Temperature range

mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #69481]	Ability of spore formation	no Confidence in %100
[Ref.: #69480]	Ability of spore formation	no Confidence in %99.975

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Name of produced compound

toxin

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68379]	D-glucose ChEBI	+	fermentation	* from API Coryne
[Ref.: #68379]	D-mannitol ChEBI	-	fermentation	* from API Coryne
[Ref.: #68379]	D-ribose ChEBI	+	fermentation	* from API Coryne
[Ref.: #68379]	D-xylose ChEBI	-	fermentation	* from API Coryne
[Ref.: #68379]	esculin ChEBI	-	hydrolysis	* from API Coryne
[Ref.: #68379]	gelatin ChEBI	-	hydrolysis	* from API Coryne
[Ref.: #68379]	glycogen ChEBI	-	fermentation	* from API Coryne
[Ref.: #68379]	lactose ChEBI	-	fermentation	* from API Coryne
[Ref.: #68379]	maltose ChEBI	+	fermentation	* from API Coryne
[Ref.: #68379]	nitrate ChEBI	+	reduction	* from API Coryne
[Ref.: #68379]	sucrose ChEBI	-	fermentation	* from API Coryne
[Ref.: #68379]	urea ChEBI	-	hydrolysis	* from API Coryne
	Only first 10 entries are displayed. Click here to see all.

	Enzyme	Enzyme activity	EC number
[Ref.: #68379]	alkaline phosphatase	-	3.1.3.1	* from API Coryne
[Ref.: #68379]	alpha-glucosidase	-	3.2.1.20	* from API Coryne
[Ref.: #68379]	beta-galactosidase	-	3.2.1.23	* from API Coryne
[Ref.: #68379]	beta-glucosidase	-	3.2.1.21	* from API Coryne
[Ref.: #68379]	beta-glucuronidase	-	3.2.1.31	* from API Coryne
[Ref.: #68379]	catalase	+	1.11.1.6	* from API Coryne
[Ref.: #68379]	gelatinase	-		* from API Coryne
[Ref.: #68379]	N-acetyl-beta-glucosaminidase	-	3.2.1.52	* from API Coryne
[Ref.: #68379]	pyrazinamidase	-	3.5.1.B15	* from API Coryne
[Ref.: #68379]	pyrrolidonyl arylamidase	-	3.4.19.3	* from API Coryne
[Ref.: #68379]	urease	-	3.5.1.5	* from API Coryne
	Only first 10 entries are displayed. Click here to see all.

API® Coryne:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Reduction of nitrateNIT	PyrazinamidasePYZ	Pyrrolidonyl arylamidasePYRA	Alkaline phosphatasePAL	beta-Glucuronidasebeta GUR	beta-Galactosidasebeta GAL	alpha-Glucosidasealpha GLU	N-Acetyl-beta-Glucosidasebeta NAG	Esculin hydrolysis/beta-GlucosidaseESC	Urease/urea hydrolysisURE	Gelatinase/gelatin hydrolysisGEL	Control fermentationControl	Fermentation of D-glucoseGLU	Fermentation of D-riboseRIB	Fermentation of D-xyloseXYL	Fermentation of D-mannitolMAN	Fermentation of maltoseMAL	Fermentation of lactoseLAC	Fermentation of sucroseSAC	Fermentation of glycogenGLYG	CatalaseCAT
[Ref.: #11439]	4255	+	-	-	-	-	-	-	-	-	-	-	-	+	+	-	-	+	-	-	-	+

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

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Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Corynebacterium diphtheriae DSM 43989	GCA_001913255	contig	GenBank	1717 tax ID	*
[Ref.: #66792]	Corynebacterium diphtheriae strain DSM 43989	1717.286	wgs	PATRIC	1717 tax ID	*
[Ref.: #66792]	Corynebacterium diphtheriae strain FDAARGOS_1553	1717.765	complete	PATRIC	1717 tax ID	*
[Ref.: #66792]	Corynebacterium diphtheriae strain FDAARGOS_1553	1717.761	complete	PATRIC	1717 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Corynebacterium diphtheriae strain DSM 43989 PATRIC: 1717.286
[Ref.: #69481]	spore-forming	no	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Corynebacterium diphtheriae strain FDAARGOS_1553 PATRIC: 1717.765
[Ref.: #69480]	motile	no	95.411	no
[Ref.: #69480]	gram-positive	yes	93.173	no
[Ref.: #69480]	anaerobic	no	97.222	no
[Ref.: #69480]	aerobic	no	83.48	no
[Ref.: #69480]	halophile	yes	65.531	no
[Ref.: #69480]	spore-forming	no	93.77	no
[Ref.: #69480]	glucose-util	yes	87.958	no
[Ref.: #69480]	flagellated	no	97.459	no
[Ref.: #69480]	thermophile	no	93.407	yes
[Ref.: #69480]	glucose-ferment	yes	78.541	no

Availability in culture collections External links

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Culture collection no.

DSM 43989, ATCC 13812

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SI-ID 35897

Literature:

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Of mice and men: Interaction of Corynebacterium diphtheriae strains with murine and human phagocytes.	Weerasekera D, Fastner T, Lang R, Burkovski A, Ott L	Virulence	10.1080/21505594.2019.1614384	2019	*
Enzymology	The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress.	Hillion M, Imber M, Pedre B, Bernhardt J, Saleh M, Loi VV, Maass S, Becher D, Astolfi Rosado L, Adrian L, Weise C, Hell R, Wirtz M, Messens J, Antelmann H	Sci Rep	10.1038/s41598-017-05206-2	2017	*
Metabolism	Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.	Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R	Infect Immun	10.1128/IAI.00075-17	2017	*

References

#11439

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 43989

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68379

Automatically annotated from API Coryne .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#72668

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID35897.1 )

* These data were automatically processed and therefore are not curated

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Corynebacterium diphtheriae strain DSM 43989

Corynebacterium diphtheriae strain FDAARGOS_1553

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