Corynebacterium diphtheriae (CCUG 5865, NCTC 10356)
Corynebacterium diphtheriae CCUG 5865 is a bacterium that was isolated from Nose swab.
genome sequence 16S sequence BacteriaName and taxonomic classification
| @ref 20215 |
Last LPSN update
2026-05-29 08:40:01 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Mycobacteriales |
| Family Corynebacteriaceae |
| Genus Corynebacterium |
| Species Corynebacterium diphtheriae |
| Full scientific name Corynebacterium diphtheriae (Kruse 1886) Lehmann and Neumann 1896 (Approved Lists 1980) |
| Synonyms (1) |
Physiology and metabolism
Oxygen tolerance
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | facultative anaerobe | 94.013 |
Spore formation
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 99.344 |
Metabolite utilization
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68381 | 40585 ChEBI | alpha-cyclodextrin | - | builds acid from | from API rID32STR |
| 68381 | 29016 ChEBI | arginine | - | hydrolysis | from API rID32STR |
| 68381 | 18333 ChEBI | D-arabitol | - | builds acid from | from API rID32STR |
| 68379 | 17634 ChEBI | D-glucose | + | fermentation | from API Coryne |
| 68381 | 16899 ChEBI | D-mannitol | - | builds acid from | from API rID32STR |
| 68379 | 16899 ChEBI | D-mannitol | - | fermentation | from API Coryne |
| 68381 | 16988 ChEBI | D-ribose | - | builds acid from | from API rID32STR |
| 68379 | 16988 ChEBI | D-ribose | + | fermentation | from API Coryne |
| 68381 | 16443 ChEBI | D-tagatose | - | builds acid from | from API rID32STR |
| 68379 | 65327 ChEBI | D-xylose | - | fermentation | from API Coryne |
| 68379 | 4853 ChEBI | esculin | - | hydrolysis | from API Coryne |
| 68379 | 5291 ChEBI | gelatin | - | hydrolysis | from API Coryne |
| 68381 | 28087 ChEBI | glycogen | - | builds acid from | from API rID32STR |
| 68379 | 28087 ChEBI | glycogen | - | fermentation | from API Coryne |
| 68381 | 606565 ChEBI | hippurate | - | hydrolysis | from API rID32STR |
| 68381 | 30849 ChEBI | L-arabinose | - | builds acid from | from API rID32STR |
| 68381 | 17716 ChEBI | lactose | - | builds acid from | from API rID32STR |
| 68379 | 17716 ChEBI | lactose | - | fermentation | from API Coryne |
| 68381 | 17306 ChEBI | maltose | + | builds acid from | from API rID32STR |
| 68379 | 17306 ChEBI | maltose | + | fermentation | from API Coryne |
| 68381 | 6731 ChEBI | melezitose | - | builds acid from | from API rID32STR |
| 68381 | 28053 ChEBI | melibiose | - | builds acid from | from API rID32STR |
| 68381 | 320055 ChEBI | methyl beta-D-glucopyranoside | - | builds acid from | from API rID32STR |
| 68379 | 17632 ChEBI | nitrate | - | reduction | from API Coryne |
| 68381 | 27941 ChEBI | pullulan | - | builds acid from | from API rID32STR |
| 68381 | 16634 ChEBI | raffinose | - | builds acid from | from API rID32STR |
| 68381 | 30911 ChEBI | sorbitol | - | builds acid from | from API rID32STR |
| 68379 | 17992 ChEBI | sucrose | - | fermentation | from API Coryne |
| 68381 | 17992 ChEBI | sucrose | - | builds acid from | from API rID32STR |
| 68381 | 27082 ChEBI | trehalose | - | builds acid from | from API rID32STR |
| 68381 | 16199 ChEBI | urea | + | hydrolysis | from API rID32STR |
| 68379 | 16199 ChEBI | urea | - | hydrolysis | from API Coryne |
Metabolite production
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68381 | 15688 ChEBI | acetoin | from API rID32STR |
Metabolite tests
| @ref | Chebi-ID | Metabolite | Voges-proskauer-test | |
|---|---|---|---|---|
| 68381 | 15688 ChEBI | acetoin | - | from API rID32STR |
Enzymes
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68381 | Alanyl-Phenylalanyl-Proline arylamidase | + | from API rID32STR | |
| 68381 | alkaline phosphatase | - | 3.1.3.1 | from API rID32STR |
| 68379 | alkaline phosphatase | - | 3.1.3.1 | from API Coryne |
| 68381 | alpha-galactosidase | - | 3.2.1.22 | from API rID32STR |
| 68381 | arginine dihydrolase | - | 3.5.3.6 | from API rID32STR |
| 68381 | beta-galactosidase | - | 3.2.1.23 | from API rID32STR |
| 68379 | beta-galactosidase | - | 3.2.1.23 | from API Coryne |
| 68381 | beta-glucosidase | - | 3.2.1.21 | from API rID32STR |
| 68379 | beta-glucosidase | - | 3.2.1.21 | from API Coryne |
| 68381 | beta-glucuronidase | - | 3.2.1.31 | from API rID32STR |
| 68379 | beta-glucuronidase | - | 3.2.1.31 | from API Coryne |
| 68381 | beta-mannosidase | - | 3.2.1.25 | from API rID32STR |
| 68379 | catalase | + | 1.11.1.6 | from API Coryne |
| 68379 | gelatinase | - | from API Coryne | |
| 68381 | glycyl tryptophan arylamidase | - | from API rID32STR | |
| 68381 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API rID32STR |
| 68379 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API Coryne |
| 68379 | pyrazinamidase | - | 3.5.1.B15 | from API Coryne |
| 68379 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API Coryne |
| 68381 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API rID32STR |
| 68381 | urease | + | 3.5.1.5 | from API rID32STR |
| 68379 | urease | - | 3.5.1.5 | from API Coryne |
Fatty acid profile
Metadata FA analysis  | |||||||||||||||||||||||||||||||
| @ref | 44867 | ||||||||||||||||||||||||||||||
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API rID32STR
| @ref | ADH (Arg) | beta GLU | beta GAR | beta GUR | alpha GAL | PAL | RIB | MAN | SOR | LAC | TRE | RAF | SAC | LARA | DARL | Acid from alpha-cyclodextrinCDEX | Acetoin production (Voges Proskauer test)VP | Alanyl-Phenylalanyl-Proline arylamidaseAPPA | beta GAL | Pyrrolidonyl arylamidasePyrA | N-Acetyl-glucosaminidasebeta NAG | Glycyl-tryptophan arylamidaseGTA | HIP | GLYG | PUL | MAL | MEL | MLZ | Acidification of methyl beta-D-glucopyranosideMbeta DG | TAG | beta MAN | URE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 44867 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | + | - | - | - | - | - | - | - | + | - | - | - | - | - | + |
Sequence information
Genome sequences
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 124043 | ASM220097v1 assembly for Corynebacterium diphtheriae subsp. lausannense CCUG 5865 | scaffold | GCA_002200975   | 2014537.3  | 2315254 | 25.9 | |
Genome browser: GCA_002200975
16S sequences
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 124043 | Corynebacterium diphtheriae strain CD002 16S ribosomal RNA gene, partial sequence. | GQ118340 | 1441 | | 1717 | |
Literature
Literature 
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Genetics | Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s. | Grosse-Kock S, Kolodkina V, Schwalbe EC, Blom J, Burkovski A, Hoskisson PA, Brisse S, Smith D, Sutcliffe IC, Titov L, Sangal V. | BMC Genomics | 10.1186/s12864-017-4276-3 | 2017 | |
| Genetics | Phylogenomic Characterization of a Novel Corynebacterium Species Associated with Fatal Diphtheritic Stomatitis in Endangered Yellow-Eyed Penguins. | Saunderson SC, Nouioui I, Midwinter AC, Wilkinson DA, Young MJ, McInnes KM, Watts J, Sangal V. | mSystems | 10.1128/msystems.00320-21 | 2021 | |
| Complete genome sequences of four representative Corynebacterium belfantii strains. | Peng Y, Fueston H, Irfan M, Hammond J, Morales D, Ju H, Bentz ML, Heuser J, Burroughs M, Tondella ML, Weigand MR. | Microbiol Resour Announc | 10.1128/mra.00755-24 | 2024 | | |
| Case Report: Bloodstream Infection with Toxigenic Corynebacterium diphtheriae and Gram-Negative Sepsis in a Child with Burns. | Jamir I, Ketan P, Anguraj S, Jahan L, Parameswaran N, Divakarjose RR, Sastry AS. | Am J Trop Med Hyg | 10.4269/ajtmh.21-1233 | 2022 | | |
| Pathogenicity | Detection of diphtheria toxin production by toxigenic corynebacteria using an optimized Elek test. | Melnikov VG, Berger A, Sing A. | Infection | 10.1007/s15010-022-01903-x | 2022 | |
| Lateral flow immunoassay-based laboratory algorithm for rapid diagnosis of diphtheria. | Melnikov VG, Berger A, Dangel A, Sing A. | Open Res Eur | 10.12688/openreseurope.15038.1 | 2023 | | |
| Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants. | Worachartcheewan A, Pingaew R, Prachayasittikul V, Apiraksattayakul S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. | EXCLI J | 10.17179/excli2024-7855 | 2025 | | |
| Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR. | Rosana Y, Prilandari LI, Ajisman R, Hartono TS, Yasmon A. | Iran J Microbiol | 10.18502/ijm.v12i6.5024 | 2020 | | |
| Application of loop-mediated isothermal amplification combined with colorimetric and lateral flow dipstick visualization as the potential point-of-care testing for Corynebacterium diphtheriae. | Zasada AA, Wiatrzyk A, Czajka U, Brodzik K, Forminska K, Mosiej E, Prygiel M, Krysztopa-Grzybowska K, Wdowiak K. | BMC Infect Dis | 10.1186/s12879-020-05037-z | 2020 | | |
| Phylogeny | Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals. | Moller J, Musella L, Melnikov V, Geissdorfer W, Burkovski A, Sangal V. | Antonie Van Leeuwenhoek | 10.1007/s10482-020-01430-5 | 2020 | |
| Phylogeny | Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015. | du Plessis M, Wolter N, Allam M, de Gouveia L, Moosa F, Ntshoe G, Blumberg L, Cohen C, Smith M, Mutevedzi P, Thomas J, Horne V, Moodley P, Archary M, Mahabeer Y, Mahomed S, Kuhn W, Mlisana K, McCarthy K, von Gottberg A. | Emerg Infect Dis | 10.3201/eid2308.162039 | 2017 | |
| Synthesis of acetamidosulfonamide derivatives with antioxidative and QSAR studies. | Worachartcheewan A, Pisutjaroenpong S, Pingaew R, Prachayasittikul S, Siriwong S, Ruchirawat S, Prachayasittikul V. | EXCLI J | 10.17179/excli2021-4590 | 2022 | | |
| Enzymology | Novel Corynebacterium diphtheriae in domestic cats. | Hall AJ, Cassiday PK, Bernard KA, Bolt F, Steigerwalt AG, Bixler D, Pawloski LC, Whitney AM, Iwaki M, Baldwin A, Dowson CG, Komiya T, Takahashi M, Hinrikson HP, Tondella ML. | Emerg Infect Dis | 10.3201/eid1604.091107 | 2010 | |
| Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep. | Prachayasittikul S, Manam P, Chinworrungsee M, Isarankura-Na-Ayudhya C, Ruchirawat S, Prachayasittikul V. | Molecules | 10.3390/molecules14114414 | 2009 | | |
| Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities. | Cherdtrakulkiat R, Boonpangrak S, Sinthupoom N, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. | Biochem Biophys Rep | 10.1016/j.bbrep.2016.03.014 | 2016 | | |
| Phylogeny | Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR. | Sing A, Berger A, Schneider-Brachert W, Holzmann T, Reischl U. | J Clin Microbiol | 10.1128/jcm.00452-11 | 2011 | |
| A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity. | Prachayasittikul S, Pingaew R, Worachartcheewan A, Ruchirawat S, Prachayasittikul V. | EXCLI J | 2010 | | ||
| Phylogeny | Diphtheria in the Republic of Georgia: use of molecular typing techniques for characterization of Corynebacterium diphtheriae strains. | Sulakvelidze A, Kekelidze M, Gomelauri T, Deng Y, Khetsuriani N, Kobaidze K, De Zoysa A, Efstratiou A, Morris JG, Imnadze P. | J Clin Microbiol | 10.1128/jcm.37.10.3265-3270.1999 | 1999 | |
| Nontoxigenic tox-bearing Corynebacterium ulcerans infection among game animals, Germany. | Eisenberg T, Kutzer P, Peters M, Sing A, Contzen M, Rau J. | Emerg Infect Dis | 10.3201/eid2003.130423 | 2014 | | |
| Phylogeny | Characterization of Corynebacterium species in macaques. | Venezia J, Cassiday PK, Marini RP, Shen Z, Buckley EM, Peters Y, Taylor N, Dewhirst FE, Tondella ML, Fox JG. | J Med Microbiol | 10.1099/jmm.0.045377-0 | 2012 | |
| Development of a real-time fluorescence PCR assay for rapid detection of the diphtheria toxin gene. | Mothershed EA, Cassiday PK, Pierson K, Mayer LW, Popovic T. | J Clin Microbiol | 10.1128/jcm.40.12.4713-4719.2002 | 2002 | | |
| The genus spilanthes ethnopharmacology, phytochemistry, and pharmacological properties: a review. | Paulraj J, Govindarajan R, Palpu P. | Adv Pharmacol Sci | 10.1155/2013/510298 | 2013 | | |
| Enzymology | A modified Elek test for detection of toxigenic corynebacteria in the diagnostic laboratory. | Engler KH, Glushkevich T, Mazurova IK, George RC, Efstratiou A. | J Clin Microbiol | 10.1128/jcm.35.2.495-498.1997 | 1997 | |
| Heterogeneity of diphtheria toxin gene, tox, and its regulatory element, dtxR, in Corynebacterium diphtheriae strains causing epidemic diphtheria in Russia and Ukraine. | Nakao H, Pruckler JM, Mazurova IK, Narvskaia OV, Glushkevich T, Marijevski VF, Kravetz AN, Fields BS, Wachsmuth IK, Popovic T. | J Clin Microbiol | 10.1128/jcm.34.7.1711-1716.1996 | 1996 | | |
| Phylogeny | Rapid screening for toxigenic Corynebacterium diphtheriae by the polymerase chain reaction. | Pallen MJ. | J Clin Pathol | 10.1136/jcp.44.12.1025 | 1991 | |
| Metabolism | Double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of toxin-producing Corynebacterium diphtheriae. | Nielsen PB, Koch C, Friis H, Heron I, Prag J, Schmidt J. | J Clin Microbiol | 10.1128/jcm.25.7.1280-1284.1987 | 1987 | |
| Immunochromatographic strip test for rapid detection of diphtheria toxin: description and multicenter evaluation in areas of low and high prevalence of diphtheria. | Engler KH, Efstratiou A, Norn D, Kozlov RS, Selga I, Glushkevich TG, Tam M, Melnikov VG, Mazurova IK, Kim VE, Tseneva GY, Titov LP, George RC. | J Clin Microbiol | 10.1128/jcm.40.1.80-83.2002 | 2002 | | |
| High therapeutic potential of Spilanthes acmella: A review. | Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. | EXCLI J | 2013 | | ||
| Comparison of phenotypic and genotypic methods for detection of diphtheria toxin among isolates of pathogenic corynebacteria. | Efstratiou A, Engler KH, Dawes CS, Sesardic D. | J Clin Microbiol | 10.1128/jcm.36.11.3173-3177.1998 | 1998 | | |
| Metabolism | Rapid enzyme immunoassay for determination of toxigenicity among clinical isolates of corynebacteria. | Engler KH, Efstratiou A. | J Clin Microbiol | 10.1128/jcm.38.4.1385-1389.2000 | 2000 | |
| Enzymology | ACP Broadsheet no 125: July 1990. Bacteriological diagnosis of diphtheria. | Brooks R, Joynson DH. | J Clin Pathol | 10.1136/jcp.43.7.576 | 1990 | |
| Development of a direct PCR assay for detection of the diphtheria toxin gene. | Nakao H, Popovic T. | J Clin Microbiol | 10.1128/jcm.35.7.1651-1655.1997 | 1997 | | |
| Enzymology | Screening tests for pathogenic corynebacteria. | Colman G, Weaver E, Efstratiou A. | J Clin Pathol | 10.1136/jcp.45.1.46 | 1992 | |
| Metabolism | Detection of toxin production by Corynebacterium diphtheriae: results of a trial organised as part of the United Kingdom National External Microbiological Quality Assessment Scheme. | Snell JJ, Demello JV, Gardner PS, Kwantes W, Brooks R. | J Clin Pathol | 10.1136/jcp.37.7.796 | 1984 | |
| Metabolism | Copper complexes of nicotinic-aromatic carboxylic acids as superoxide dismutase mimetics. | Suksrichavalit T, Prachayasittikul S, Piacham T, Isarankura-Na-Ayudhya C, Nantasenamat C, Prachayasittikul V. | Molecules | 10.3390/molecules13123040 | 2008 | |
| Use of quantitative 16S ribosomal DNA detection for diagnosis of central vascular catheter-associated bacterial infection. | Warwick S, Wilks M, Hennessy E, Powell-Tuck J, Small M, Sharp J, Millar MR. | J Clin Microbiol | 10.1128/jcm.42.4.1402-1408.2004 | 2004 | | |
| Pathogenicity | [Micro technologies in express diagnostics of toxigenic Corynebacterium diphtheriae strains]. | Kraeva LA, Zimina TM, Tseneva GIa, Solov'ev AV | Zh Mikrobiol Epidemiol Immunobiol | 2011 | | |
| Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides. | Treeratanapiboon L, Worachartcheewan A, Suksrichavalit T, Kiatfuengfoo R, Prachayasittikul S, Ruchirawat S, Prachayasittikul V | EXCLI J | 2011 | | ||
| New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. | Prachayasittikul S, Saraban P, Cherdtrakulkiat R, Ruchirawat S, Prachayasittikul V | EXCLI J | 2010 | | ||
| Pathogenicity | Bioactive metabolites from Spilanthes acmella Murr. | Prachayasittikul S, Suphapong S, Worachartcheewan A, Lawung R, Ruchirawat S, Prachayasittikul V | Molecules | 10.3390/molecules14020850 | 2009 | |
| Enzymology | Antimicrobial and antioxidative activities of bioactive constituents from Hydnophytum formicarum Jack. | Prachayasittikul S, Buraparuangsang P, Worachartcheewan A, Isarankura-Na-Ayudhya C, Ruchirawat S, Prachayasittikul V | Molecules | 10.3390/molecules13040904 | 2008 | |
| Phylogeny | Corynebacterium imitans sp. nov. isolated from patients with suspected diphtheria. | Funke G, Efstratiou A, Kuklinska D, Hutson RA, De Zoysa A, Engler KH, Collins MD. | J Clin Microbiol | 10.1128/jcm.35.8.1978-1983.1997 | 1997 | |
| Phylogeny | Distinct Genomic Features Characterize Two Clades of Corynebacterium diphtheriae: Proposal of Corynebacterium diphtheriae Subsp. diphtheriae Subsp. nov. and Corynebacterium diphtheriae Subsp. lausannense Subsp. nov. | Tagini F, Pillonel T, Croxatto A, Bertelli C, Koutsokera A, Lovis A, Greub G | Front Microbiol | 10.3389/fmicb.2018.01743 | 2018 | |
How to cite
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive141738.20260601.11
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain dataIsabel Schober, Julia Koblitz, Joaquim Sardà Carbasse, Christian Ebeling, Marvin Leon Schmidt, Adam Podstawka, Rohit Gupta, Vinodh Ilangovan, Javad Chamanara, Jörg Overmann, Lorenz Christian Reimer
Nucleic Acids Research; database issue 2025.
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