Clostridium tyrobutyricum (DSM 2637, ATCC 25755, NCIMB 10635)

Name: Clostridium tyrobutyricum (DSM 2637, ATCC 25755, NCIMB 10635)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 2738

Type strain

Culture col. no. DSM 2637 ATCC 25755 NCIMB 10635 CCUG 48315 CIP 105092 5 more

NCBI tax ID(s) 1121342 1519

Special Collections DSMZ CCUG JCM CIP

History <- ATCC; ATCC 25755 <- L. DS. Smith, Virginia Polytechnical Institute and State University, Blacksburg, V., USA; VPI 5392 <- NCIB; NCIMB 10635 <- G. Hobbs, Torry Research Station, Aberdeen, U.K. CIP 105092 <-- NCIMB 10635 <-- G. Hobbs. CIP <- 1997, NCIMB <- G. Hobbs

Links

Clostridium tyrobutyricum DSM 2637 is an anaerobe, spore-forming, mesophilic prokaryote of the family Clostridiaceae.

spore-forming Gram-positive rod-shaped anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 1993

LMG 1285,ATCC 25755,NCIB 10635,CIP 105092,NCIMB 10635,JCM 11008,CECT 4011,CCUG 48315,BCRC 14535,CCRC 14535,DSM 2637

@ref 20215

Last LPSN update 2025-12-16 09:47:23

Domain Bacillati

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Clostridiaceae

Genus Clostridium

Species Clostridium tyrobutyricum

Full scientific name Clostridium tyrobutyricum van Beynum and Pette 1935 (Approved Lists 1980)

BacDive ID	Other strains from **Clostridium tyrobutyricum** (5)	Type strain
2735	C. tyrobutyricum G33R, DSM 663
2736	C. tyrobutyricum W55, DSM 664
2737	C. tyrobutyricum La1, DSM 1460
135616	C. tyrobutyricum CIP 60.31
139499	C. tyrobutyricum CIP 60.51

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
123702	positive	rod-shaped

Colony morphology

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
1182	PY + X MEDIUM (N2/CO2) (DSMZ Medium 104c)	Medium recipe at MediaDive	Name: PY + X MEDIUM (N2/CO2) (DSMZ Medium 104c) Composition: Yeast extract 10.0 g/l D-Glucose 5.0 g/l Trypticase peptone 5.0 g/l Meat peptone 5.0 g/l Na2CO3 1.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Sodium resazurin 0.0005 g/l Distilled water
1182	CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)	Medium recipe at MediaDive	Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water
35775	MEDIUM 20 - for Anaerobic bacteria		Agar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)
123702	CIP Medium 20	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
1182	positive	growth	37	mesophilic
35775	positive	growth	37	mesophilic
58078	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
1182	anaerobe
58078	anaerobe
123702	anaerobe
125439	anaerobe	94.7

Spore formation

123702

Spore formationyes

Compound production

1182

Compoundenoate reductase

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
123702	17057 ChEBI	cellobiose	-	degradation
123702	17108 ChEBI	D-arabinose	-	degradation
123702	15824 ChEBI	D-fructose	+	degradation
123702	17634 ChEBI	D-glucose	+	degradation
123702	65327 ChEBI	D-xylose	-	degradation
123702	4853 ChEBI	esculin	-	hydrolysis
123702	17716 ChEBI	lactose	-	degradation
123702	17306 ChEBI	maltose	-	degradation
123702	17632 ChEBI	nitrate	+	reduction
123702	17632 ChEBI	nitrate	+	respiration
123702	16301 ChEBI	nitrite	-	reduction
123702	17814 ChEBI	salicin	-	degradation
123702	17992 ChEBI	sucrose	-	degradation

Metabolite production

@ref	Chebi-ID	Metabolite	Production
123702	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
123702	amylase	-
68382	beta-galactosidase	-	3.2.1.23	from API zym
123702	beta-galactosidase	-	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
123702	caseinase	-	3.4.21.50
123702	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
123702	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	-		from API zym
123702	gelatinase	-
123702	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
123702	lipase	-
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
123702	oxidase	-
123702	protease	-
68382	trypsin	+	3.4.21.4	from API zym
123702	tween esterase	-
123702	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
123702	-	-	+	-	-	+	-	-	+	-	+	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Taxonmaps

69479

Global distribution of 16S sequence LC037226 (>99% sequence identity) for Clostridium tyrobutyricum subclade from Microbeatlas

Aquatic Samples	1607
Soil Samples	2222
Animal Samples	2006
Plant Samples	573
Total Samples	6408

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
1182	1	Risk group (German classification) According to TRBA 466
123702	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM42980v1 assembly for Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008	scaffold	GCA_000429805	1121342.5	2523533604	1121342	70.37
66792	ATCC25755 assembly for Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008	contig	GCA_000359585	1121342.3	2554235038	1121342	64.17
66792	ASM39237v2 assembly for Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008	contig	GCA_000392375	1121342.4	2554235112	1121342	43.02
66792	ASM97430v1 assembly for Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008	contig	GCA_000974305	1121342.10	2740892193	1121342

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Clostridium tyrobutyricum strain ATCC 25755 16S ribosomal RNA gene, partial sequence	DQ911272	319	1519
1182	Clostridium tyrobutyricum strain ATCC 25755 16S ribosomal RNA gene, partial sequence	M59113	1456	1519
67770	Clostridium tyrobutyricum gene for 16S ribosomal RNA, partial sequence, strain: JCM 11008	LC037226	1470	1519

GC content

@ref	GC-content (mol%)	Method
1182	28.5
67770	28	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008
NCBI: GCA_000429805

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	94.70	no
125439	gram_stain	BacteriaNetⓘ	variable	71.10	no
125439	motility	BacteriaNetⓘ	yes	73.60	no
125439	spore_formation	BacteriaNetⓘ	yes	72.20	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Clostridium tyrobutyricum DSM 2637 = ATCC 25755 = JCM 11008 DSM 2637
NCBI: GCA_000429805.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	64.30	no
125438	anaerobic	anaerobicⓘ	yes	89.88	yes
125438	aerobic	aerobicⓘ	no	92.85	yes
125438	spore-forming	spore-formingⓘ	yes	77.95	no
125438	thermophilic	thermophileⓘ	no	88.70	no
125438	flagellated	motile2+ⓘ	yes	81.23	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Integrated co-cultivation and subsequent esterification: Harnessing Saccharomyces cerevisiae and Clostridium tyrobutyricum for streamlined ester production.	Oehlenschlager K, Lorenz M, Schepp E, Di Nonno S, Holtmann D, Ulber R.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02698-3	2025
	Clostridium strain FAM25158, a unique endospore-forming bacterium related to Clostridium tyrobutyricum and isolated from Emmental cheese shows low tolerance to salt.	Princic L, Burtscher J, Sacken P, Krajnc T, Domig KJ.	Front Microbiol	10.3389/fmicb.2024.1353321	2024
	Specificity of the AMP-6000 Method for Enumerating Clostridium Endospores in Milk.	Burtscher J, Rudavsky T, Zitz U, Domig KJ.	Foods	10.3390/foods13081192	2024
	Strain-Dependent Cheese Spoilage Potential of Clostridium tyrobutyricum.	Podrzaj L, Burtscher J, Kuller F, Domig KJ.	Microorganisms	10.3390/microorganisms8111836	2020
	Characterization of Clostridium tyrobutyricum Strains Using Three Different Typing Techniques.	Burtscher J, Kuller F, Dreier M, Arias-Roth E, Drissner D, Domig KJ.	Microorganisms	10.3390/microorganisms8071057	2020
	A Series of Efficient Umbrella Modeling Strategies to Track Irradiation-Mutation Strains Improving Butyric Acid Production From the Pre-development Earlier Stage Point of View.	Cao L, Gao Y, Wang XZ, Shu GY, Hu YN, Xie ZP, Cui W, Guo XP, Zhou X.	Front Bioeng Biotechnol	10.3389/fbioe.2021.609345	2021
	A metagenome-level analysis of a microbial community fermenting ultra-filtered milk permeate.	Walters KA, Mohan G, Myers KS, Ingle AT, Donohue TJ, Noguera DR.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1173656	2023
Pathogenicity	The gut-immune-brain axis in neurodevelopment and neurological disorders.	Park JC, Im SH.	Microbiome Res Rep	10.20517/mrr.2022.11	2022
	The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-beta-D-glucans.	Chang SC, Kao MR, Saldivar RK, Diaz-Moreno SM, Xing X, Furlanetto V, Yayo J, Divne C, Vilaplana F, Abbott DW, Hsieh YSY.	Nat Commun	10.1038/s41467-023-40214-z	2023
	The gut microbiota influences blood-brain barrier permeability in mice.	Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyas B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S.	Sci Transl Med	10.1126/scitranslmed.3009759	2014
Enzymology	Enhanced tolerance of Clostridium tyrobutyricum to lignin-derived phenolic acids by overexpressing native reductases.	Wei H, Wang Y, Zeng Y, Yang N, Jiang Y, Suo Y.	J Biotechnol	10.1016/j.jbiotec.2025.04.001	2025
	Enhanced tolerance of Clostridium tyrobutyricum to furan derivatives for efficient butyric acid production by overexpressing native transporter genes	Wan L, Qin S, Wei H, Luo L, Liu S, Suo Y.	Industrial crops and products.		2023
	Efficient production of butyric acid from lignocellulosic biomass by revealing the mechanisms of Clostridium tyrobutyricum tolerance to phenolic inhibitors.	Luo L, Wei H, Kong D, Wan L, Jiang Y, Qin S, Suo Y.	Bioresour Technol	10.1016/j.biortech.2024.130427	2024
	De novo biosynthesis of butyl butyrate in engineered Clostridium tyrobutyricum.	Guo X, Zhang H, Feng J, Yang L, Luo K, Fu H, Wang J.	Metab Eng	10.1016/j.ymben.2023.03.009	2023
	Microbial cell factory for butyl butyrate production: Knowledges and perspectives.	Guo X, Ding Y, Chen Y, Fu H, Wang J.	Microb Biotechnol	10.1111/1751-7915.14502	2024
	The Physiological Functions of AbrB on Sporulation, Biofilm Formation and Carbon Source Utilization in Clostridium tyrobutyricum.	Luo K, Guo X, Zhang H, Fu H, Wang J.	Bioengineering (Basel)	10.3390/bioengineering9100575	2022
Genetics	Production of a Bacteriocin Like Protein PEG 446 from Clostridium tyrobutyricum NRRL B-67062.	Liu S, Lu SY, Patel M, Qureshi N, Dunlap C, Hoecker E, Skory CD.	Probiotics Antimicrob Proteins	10.1007/s12602-023-10211-1	2024
Enzymology	Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum.	Feng J, Guo X, Cai F, Fu H, Wang J.	Biotechnol Biofuels Bioprod	10.1186/s13068-022-02169-z	2022
	Functional Characterization of Clostridium tyrobutyricum L319: A Promising Next-Generation Probiotic for Short-Chain Fatty Acid Production.	Yang Z, Amal FE, Yang L, Liu Y, Zhu L, Zhu Z, Jiang L.	Front Microbiol	10.3389/fmicb.2022.926710	2022
	Clostridium butyricum and Clostridium tyrobutyricum: angel or devil for necrotizing enterocolitis?	Tao R, Zong G, Pan Y, Li H, Cheng P, Deng R, Chen W, Wang A, Xia S, Tang W, Lu Y, Wei Z.	mSystems	10.1128/msystems.00732-23	2023
	Construction of Clostridium tyrobutyricum strain and ionic membrane technology combination pattern for refinery final molasses recovery and butyric acid production.	Wang B, Zhou X, Liu W, Liu MH, Mo D, Wu QF, Wang YJ, Zhang MM, Chen L, Yuan S, Zhou B, Li X, Lu D.	Front Microbiol	10.3389/fmicb.2023.1065953	2023
	Whole-Genome Sequencing and Annotation of Clostridium tyrobutyricum Strain Cirm BIA 2237, Isolated from Silage.	Munier E, Licandro-Seraut H, Achilleos C, Cachon R, Beuvier E.	Microbiol Resour Announc	10.1128/mra.00492-19	2019
	Loureirin A is a narrow-spectrum antimicrobial agent against Helicobacter pylori.	Tong Q, Yin C, Hang X, Bai Y, Zhang C, Xu J, Huang Y, Ge Y, Chen T, Zeng L, Jia J, Bi H.	Antimicrob Agents Chemother	10.1128/aac.00314-24	2024
	Impact of Nisin and Nisin-Producing Lactococcus lactis ssp. lactis on Clostridium tyrobutyricum and Bacterial Ecosystem of Cheese Matrices.	Hassan H, St-Gelais D, Gomaa A, Fliss I.	Foods	10.3390/foods10040898	2021
	Draft Genome Sequence of the Butyric Acid Producer Clostridium tyrobutyricum Strain CIP I-776 (IFP923).	Wasels F, Clement B, Lopes Ferreira N.	Genome Announc	10.1128/genomea.00048-16	2016
	Influence of Emulsifying Salts on the Growth of Bacillus thuringiensis CFBP 3476 and Clostridium perfringens ATCC 13124 in Processed Cheese.	Fusieger A, da Silva RR, Cavicchioli VQ, Rodrigues RDS, Honorato JA, de Jesus Silva SR, Pena ML, Caggia C, Nero LA, de Carvalho AF.	Foods	10.3390/foods11203217	2022
	RRNPP-type quorum-sensing systems regulate solvent formation, sporulation and cell motility in Clostridium saccharoperbutylacetonicum.	Feng J, Zong W, Wang P, Zhang ZT, Gu Y, Dougherty M, Borovok I, Wang Y.	Biotechnol Biofuels	10.1186/s13068-020-01723-x	2020
	Anaerobically Digesting Hazardous Waste Pichia pastoris Associated with Butyric Acid Cleaner Production.	Cheng W, Chen X, Gong L, Wei J, Ding J, Shi Z.	ACS Omega	10.1021/acsomega.1c05840	2022
	Advances in stress-tolerance elements for microbial cell factories.	Kuang Z, Yan X, Yuan Y, Wang R, Zhu H, Wang Y, Li J, Ye J, Yue H, Yang X.	Synth Syst Biotechnol	10.1016/j.synbio.2024.06.008	2024
	Rebalancing Redox to Improve Biobutanol Production by Clostridium tyrobutyricum.	Ma C, Ou J, Xu N, Fierst JL, Yang ST, Liu X, Liu X.	Bioengineering (Basel)	10.3390/bioengineering3010002	2015
	Enhanced extraction of butyric acid under high-pressure CO₂ conditions to integrate chemical catalysis for value-added chemicals and biofuels.	Chun J, Choi O, Sang BI.	Biotechnol Biofuels	10.1186/s13068-018-1120-1	2018
	Biodegradation of aromatic pollutants meets synthetic biology.	Xiang L, Li G, Wen L, Su C, Liu Y, Tang H, Dai J.	Synth Syst Biotechnol	10.1016/j.synbio.2021.06.001	2021
	Metabolic Engineering of Microorganisms to Produce Pyruvate and Derived Compounds.	Luo Q, Ding N, Liu Y, Zhang H, Fang Y, Yin L.	Molecules	10.3390/molecules28031418	2023
Genetics	Exploiting the Type I-B CRISPR Genome Editing System in Thermoanaerobacterium aotearoense SCUT27 and Engineering the Strain for Enhanced Ethanol Production.	Dai K, Fu H, Guo X, Qu C, Lan Y, Wang J.	Appl Environ Microbiol	10.1128/aem.00751-22	2022
	Improved assessments of bulk milk microbiota composition via sample preparation and DNA extraction methods.	Xue Z, Marco ML.	PLoS One	10.1371/journal.pone.0267992	2022
Metabolism	The acquisition of Clostridium tyrobutyricum mutants with improved bioproduction under acidic conditions after two rounds of heavy-ion beam irradiation.	Zhou X, Yang Z, Jiang TT, Wang SY, Liang JP, Lu XH, Wang L.	Sci Rep	10.1038/srep29968	2016
Metabolism	Butyric acid fermentation from pretreated and hydrolysed wheat straw by an adapted Clostridium tyrobutyricum strain.	Baroi GN, Baumann I, Westermann P, Gavala HN.	Microb Biotechnol	10.1111/1751-7915.12304	2015
	Tequila vinasses acidogenesis in a UASB reactor with Clostridium predominance.	Marino-Marmolejo EN, Corbala-Robles L, Cortez-Aguilar RC, Contreras-Ramos SM, Bolanos-Rosales RE, Davila-Vazquez G.	Springerplus	10.1186/s40064-015-1193-2	2015
	A consolidated review of commercial-scale high-value products from lignocellulosic biomass.	Zheng B, Yu S, Chen Z, Huo YX.	Front Microbiol	10.3389/fmicb.2022.933882	2022
Phylogeny	Sources of clostridia in raw milk on farms.	Julien MC, Dion P, Lafreniere C, Antoun H, Drouin P.	Appl Environ Microbiol	10.1128/aem.00913-08	2008
Phylogeny	Impact of DNA Sequencing and Analysis Methods on 16S rRNA Gene Bacterial Community Analysis of Dairy Products.	Xue Z, Kable ME, Marco ML.	mSphere	10.1128/msphere.00410-18	2018
	Developing a mesophilic co-culture for direct conversion of cellulose to butanol in consolidated bioprocess.	Wang Z, Cao G, Zheng J, Fu D, Song J, Zhang J, Zhao L, Yang Q.	Biotechnol Biofuels	10.1186/s13068-015-0266-3	2015
Metabolism	Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.	Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ.	Cell Host Microbe	10.1016/j.chom.2017.06.007	2017
Metabolism	Renewable fatty acid ester production in Clostridium.	Feng J, Zhang J, Ma Y, Feng Y, Wang S, Guo N, Wang H, Wang P, Jimenez-Bonilla P, Gu Y, Zhou J, Zhang ZT, Cao M, Jiang D, Wang S, Liu XW, Shao Z, Borovok I, Huang H, Wang Y.	Nat Commun	10.1038/s41467-021-24038-3	2021
Metabolism	Metabolic engineering of microorganisms for the production of higher alcohols.	Choi YJ, Lee J, Jang YS, Lee SY.	mBio	10.1128/mbio.01524-14	2014
Metabolism	The future of butyric acid in industry.	Dwidar M, Park JY, Mitchell RJ, Sang BI.	ScientificWorldJournal	10.1100/2012/471417	2012
Metabolism	Enhancing Butanol Production under the Stress Environments of Co-Culturing Clostridium acetobutylicum/Saccharomyces cerevisiae Integrated with Exogenous Butyrate Addition.	Luo H, Ge L, Zhang J, Zhao Y, Ding J, Li Z, He Z, Chen R, Shi Z.	PLoS One	10.1371/journal.pone.0141160	2015
	Bacteriocin-Producing Enterococcus faecium LCW 44: A High Potential Probiotic Candidate from Raw Camel Milk.	Vimont A, Fernandez B, Hammami R, Ababsa A, Daba H, Fliss I.	Front Microbiol	10.3389/fmicb.2017.00865	2017
	Spread of tetracycline resistance genes at a conventional dairy farm.	Kyselkova M, Jirout J, Vrchotova N, Schmitt H, Elhottova D.	Front Microbiol	10.3389/fmicb.2015.00536	2015
Metabolism	Identification of Clostridium tyrobutyricum as the causative agent of late blowing in cheese by species-specific PCR amplification.	Klijn N, Nieuwenhof FF, Hoolwerf JD, van der Waals CB, Weerkamp AH.	Appl Environ Microbiol	10.1128/aem.61.8.2919-2924.1995	1995
Biotechnology	Synergistic inactivation of spores of proteolytic Clostridium botulinum strains by high pressure and heat is strain and product dependent.	Bull MK, Olivier SA, van Diepenbeek RJ, Kormelink F, Chapman B.	Appl Environ Microbiol	10.1128/aem.01426-08	2009
Metabolism	Purification and amino acid sequences of piscicocins V1a and V1b, two class IIa bacteriocins secreted by Carnobacterium piscicola V1 that display significantly different levels of specific inhibitory activity.	Bhugaloo-Vial P, Dousset X, Metivier A, Sorokine O, Anglade P, Boyaval P, Marion D.	Appl Environ Microbiol	10.1128/aem.62.12.4410-4416.1996	1996
Pathogenicity	Antimicrobial activity of lysozyme against bacteria involved in food spoilage and food-borne disease.	Hughey VL, Johnson EA.	Appl Environ Microbiol	10.1128/aem.53.9.2165-2170.1987	1987
Metabolism	Nonradioactive colony hybridization assay for detection and enumeration of enterotoxigenic Clostridium perfringens in raw beef.	Baez LA, Juneja VK.	Appl Environ Microbiol	10.1128/aem.61.2.807-810.1995	1995
Enzymology	Genetic and biochemical characterization of the Lactobacillus delbrueckii subsp. lactis bacteriophage LL-H lysin.	Vasala A, Valkkila M, Caldentey J, Alatossava T.	Appl Environ Microbiol	10.1128/aem.61.11.4004-4011.1995	1995
	Simultaneous pretreatment and saccharification of bamboo for biobutanol production	Kumar S, Gujjala LKS, Banerjee R.	Industrial crops and products.	10.1016/j.indcrop.2017.02.028	2017
	Engineering circular bacteriocins: structural and functional effects of alpha-helix exchanges and disulfide introductions in circularin A.	Liu F, van Heel AJ, Kuipers OP.	Front Microbiol	10.3389/fmicb.2024.1337647	2024
	Promotion of Nitrogen Fixation of Diverse Heterotrophs by Solid-Phase Humin.	Dey S, Kasai T, Katayama A.	Front Microbiol	10.3389/fmicb.2022.853411	2022
Genetics	Complete genome sequences and comparative secretomic analysis for the industrially cultivated edible mushroom Lyophyllum decastes reveals insights on evolution and lignocellulose degradation potential.	Xu L, Yang W, Qiu T, Gao X, Zhang H, Zhang S, Cui H, Guo L, Yu H, Yu H.	Front Microbiol	10.3389/fmicb.2023.1137162	2023
	Lower termite (Coptotermes heimi) gut fibrolytic bacterial consortium: Isolation, phylogenetic characterization, fibre degradation potential and in vitro digestibility.	Kumawat PK, Sarkar S, Kumar S, Sahoo A.	PLoS One	10.1371/journal.pone.0318090	2025
	Comparative Genomic and Physiological Analysis against Clostridium scindens Reveals Eubacterium sp. c-25 as an Atypical Deoxycholic Acid Producer of the Human Gut Microbiota.	Song I, Gotoh Y, Ogura Y, Hayashi T, Fukiya S, Yokota A.	Microorganisms	10.3390/microorganisms9112254	2021
Metabolism	Metabolism of cinnamic acids by some Clostridiales and emendation of the descriptions of Clostridium aerotolerans, Clostridium celerecrescens and Clostridium xylanolyticum.	Chamkha M, Garcia JL, Labat M.	Int J Syst Evol Microbiol	10.1099/00207713-51-6-2105	2001
	Intestinal Bacteria as Powerful Trapping Lifeforms for the Elimination of Radioactive Cesium.	Saito K, Kuroda K, Suzuki R, Kino Y, Sekine T, Shinoda H, Yamashiro H, Fukuda T, Kobayashi J, Abe Y, Nishimura J, Urushihara Y, Yoneyama H, Fukumoto M, Isogai E.	Front Vet Sci	10.3389/fvets.2019.00070	2019
Metabolism	Identification and characterization of two novel clostridial bacteriocins, circularin A and closticin 574.	Kemperman R, Kuipers A, Karsens H, Nauta A, Kuipers O, Kok J.	Appl Environ Microbiol	10.1128/aem.69.3.1589-1597.2003	2003
Biotechnology	Simultaneous quantification of multiple food- and waterborne pathogens by use of microfluidic quantitative PCR.	Ishii S, Segawa T, Okabe S.	Appl Environ Microbiol	10.1128/aem.00205-13	2013
Metabolism	Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens.	Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CR, Goldfine H.	Biochim Biophys Acta	10.1016/j.bbalip.2010.12.010	2011
Metabolism	Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis.	Zhu L, Cheng J, Luo B, Feng S, Lin J, Wang S, Cronan JE, Wang H.	BMC Microbiol	10.1186/1471-2180-9-119	2009
Metabolism	Functional analysis of the gene cluster involved in production of the bacteriocin circularin A by Clostridium beijerinckii ATCC 25752.	Kemperman R, Jonker M, Nauta A, Kuipers OP, Kok J.	Appl Environ Microbiol	10.1128/aem.69.10.5839-5848.2003	2003
Enzymology	Degradation of cyanophycin by Sedimentibacter hongkongensis strain KI and Citrobacter amalonaticus strain G Isolated from an anaerobic bacterial consortium.	Obst M, Krug A, Luftmann H, Steinbuchel A.	Appl Environ Microbiol	10.1128/aem.71.7.3642-3652.2005	2005
	Amberlite resin-mediated lactate removal from whey permeate enhances butanol production by Clostridium beijerinckii.	Duduyemi A, Okereke O, Ujor VC.	Bioresour Technol	10.1016/j.biortech.2025.133727	2025
Genetics	Clostridium tyrobutyricum strains exhibit high genetic diversity and differ in their ability to cause late blowing defect in washed-curd cheese.	Trmcic A, Princic L, Pajor M, Kalenak AP, Reichler SJ, Orsi RH, Martin NH, Wiedmann M.	J Dairy Sci	10.3168/jds.2025-26686	2025
Enzymology	Metabolic Engineering of Clostridium tyrobutyricum for High-Yield n-Butanol Production by Increasing Intracellular Reducing Equivalent with NADPH-Dependent 3-Hydroxybutyryl-CoA Dehydrogenase.	Feng J, Wang Q, Guo X, Hu J, Wang G, Lu L, Qin Z, Fu H, Wang J, Yang ST.	ACS Synth Biol	10.1021/acssynbio.5c00218	2025
	Mesophilic fermentation explorations for anaerobic carboxylates production from commercial bioplastic products: PHA-based cups & PLA-based lids.	Jin Y, van den Enden R, Castrikum E, de Leeuw KD, Strik DPBTB.	Bioresour Technol	10.1016/j.biortech.2025.133512	2026
	Systems Metabolic Engineering of Clostridium tyrobutyricum for 1,3-Propanediol Production From Crude Glycerol.	Mo Y, Guo X, Lan Y, Wang J, Fu H.	Biotechnol Bioeng	10.1002/bit.29010	2025
Enzymology	In-Silico Analysis and Engineering of an Aldehyde/Alcohol Dehydrogenase for Alternative Cofactor Utilization and Selective Butanol Production.	Moore CD, Wang Q, Wang G, Feng J, Qin Z, Yang ST.	ACS Synth Biol	10.1021/acssynbio.5c00003	2025
	Effect of Saccharomyces cerevisiae inoculation on the co-fermentation of Clostridium kluyveri and Clostridium tyrobutyricum: A strategy for controlling acidity and enhancing aroma in strong-flavor Baijiu.	Qiu F, Li W, Zhang Y, Li H, Chen X, Niu J, Li X, Sun B.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2025.111172	2025
	Clostridium tyrobutyricum in Combination with Chito-oligosaccharides Modulate Inflammation and Gut Microbiota for Inflammatory Bowel Disease Treatment.	Liu Z, Bai P, Wang L, Zhu L, Zhu Z, Jiang L.	J Agric Food Chem	10.1021/acs.jafc.4c03486	2024
	Targeted microbial collaboration to enhance key flavor metabolites by inoculating Clostridium tyrobutyricum and Saccharomyces cerevisiae in the strong-flavor Baijiu simulated fermentation system.	Qiu F, Li W, Chen X, Du B, Li X, Sun B.	Food Res Int	10.1016/j.foodres.2024.114647	2024
	Targeted microbial collaboration to enhance key flavor metabolites by inoculating Clostridium tyrobutyricum and Saccharomyces cerevisiae in the strong-flavor Baijiu simulated fermentation system	Qiu F, Li W, Chen X, Du B, Li X, Sun B.	Food Research International.		2024
	Integration of food raw materials, food microbiology, and food additives: systematic research and comprehensive insights into sweet sorghum juice, Clostridium tyrobutyricum TGL-A236 and bio-butyric acid.	Liu MH, Zhou X, Zhang MM, Wang YJ, Zhou B, Ding N, Wu QF, Lei CR, Dong ZY, Ren JL, Zhao JR, Jia CL, Liu J, Lu D, Zhong HY.	Front Microbiol	10.3389/fmicb.2024.1410968	2024
	Development of inducible promoters for regulating gene expression in Clostridium tyrobutyricum for biobutanol production.	Feng J, Wang Q, Qin Z, Guo X, Fu H, Yang ST, Wang J.	Biotechnol Bioeng	10.1002/bit.28701	2024
	Identification, activity and delivery of new LysFA67 endolysin to target cheese spoilage Clostridium tyrobutyricum	Sanchez C, Garde S, Landete JM, Calzada J, Baker DJ, Evans R, Narbad A, Mayer MJ, Avila M.	Food Microbiology.		2024
	Engineering of Clostridium tyrobutyricum for butyric acid and butyl butyrate production from cassava starch.	Guo X, Li X, Feng J, Yue Z, Fu H, Wang J.	Bioresour Technol	10.1016/j.biortech.2023.129914	2024
	Isolation and characterization of new bacteriophages active against Clostridium tyrobutyricum and their role in preventing the late blowing defect of cheese	Avila M, Sanchez C, Calzada J, Mayer MJ, Berruga MI, Lopez-Diaz TM, Narbad A, Garde S.	Food Research International.		2024
	Integrating in vitro digestion and peptidomics into novel food allergenicity assessment: A study on Clostridium tyrobutyricum biomass.	Fytsilis VD, Ji R, Reiding KR, Heck AJR, van Schooten FJ, de Boer A, Vrolijk MF.	Curr Res Food Sci	10.1016/j.crfs.2025.101237	2025
Genetics	Identification, activity and delivery of new LysFA67 endolysin to target cheese spoilage Clostridium tyrobutyricum.	Sanchez C, Garde S, Landete JM, Calzada J, Baker DJ, Evans R, Narbad A, Mayer MJ, Avila M.	Food Microbiol	10.1016/j.fm.2023.104401	2024
	Hyperspectral imaging through vacuum packaging for monitoring cheese biochemical transformation caused by Clostridium metabolism	Reis MM, Dixit Y, Carr A, Tu C, Palevich F, Gupta T, Reis MG.	Food Research International.		2024
	Analysis of the formation mechanism and regulation pathway of oat silage off-flavor based on microbial-metabolite interaction network.	Jiajie Z, Xiaochen D, Junfeng H, Mingjiu W, Gentu G.	BMC Microbiol	10.1186/s12866-025-04166-2	2025
	Multiplex-PCR Detection of Clostridium tyrobutyricum, Clostridium butyricum, and Clostridium sporogenes in Raw Milk for Cheesemaking.	Floris I, Martucci F, Romano A, Marello G, Ligotti C, Bianchi DM.	Life (Basel)	10.3390/life14091093	2024
	Biodiversity and identification of spore-forming bacteria in raw milk from Korean dairy farm environment using the culturomics approach.	Park WS, Yoo J, Mun D, Choi HW, Oh S, Ham JS, Kim Y.	J Anim Sci Technol	10.5187/jast.2024.e59	2025
Genetics	Metagenomic and physicochemical profiling reveal microbial functions in pit mud for Jiang-Nong Jianxiang Baijiu fermentation.	Cao L, Sun H, Xu Z, Xu X, Shi G, Zhang J, Liang C, Li T, Liu C, Wang M, Tian S, Li E.	BMC Microbiol	10.1186/s12866-025-03884-x	2025
Metabolism	Hyperspectral imaging through vacuum packaging for monitoring cheese biochemical transformation caused by Clostridium metabolism.	Reis MM, Dixit Y, Carr A, Tu C, Palevich F, Gupta T, Reis MG.	Food Res Int	10.1016/j.foodres.2023.112866	2023
	Isolation and characterization of new bacteriophages active against Clostridium tyrobutyricum and their role in preventing the late blowing defect of cheese.	Avila M, Sanchez C, Calzada J, Mayer MJ, Berruga MI, Lopez-Diaz TM, Narbad A, Garde S.	Food Res Int	10.1016/j.foodres.2022.112222	2023
Pathogenicity	Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response.	Xie S, Fang L, Deng N, Shen J, Tan Z, Peng X.	Med Sci Monit	10.12659/msm.944185	2024
	Effect of NaCl and ripening time on spore germination by measuring the hydrogen production of Clostridium tyrobutyricum UC7086 in a hard cheese model	Bellassi P, Cappa F, Bassi D, Morelli L.	Int Dairy J		2022
Stress	Composition and fate of heat-resistant anaerobic spore-formers in the milk powder production line.	Porcellato D, Kristiansen H, Finton MD, Leanti La Rosa S, da Silva Duarte V, Skeie SB.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2023.110281	2023
	Development of a new multiplex quantitative real-time polymerase chain reaction method for Clostridium butyricum, Clostridium sporogenes and Clostridium tyrobutyricum detection in cheese	Sahiner A, Caliskan S, Halat E.	Lebensm Wiss Technol		2022
	Inhibitory activity of aromatic plant extracts against dairy-related Clostridium species and their use to prevent the late blowing defect of cheese.	Avila M, Calzada J, Munoz-Tebar N, Sanchez C, Ortiz de Elguea-Culebras G, Carmona M, Molina A, Berruga MI, Garde S.	Food Microbiol	10.1016/j.fm.2022.104185	2023
	Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of ethyl crotonate	Zhang G, Kang X, Xie M, Wei M, Zhang Y, Li Q, Guo X, Wu X, Chen Y.	Lebensm Wiss Technol		2022
Enzymology	Biosorption of lead ions from aqueous solution by Clostridium tyrobutyricum immobilized in macroporous Ca-alginate-lignin beads.	Zheng W, Zhao Q, Malkmes MJ, Gao G, He J, Zheng L, Jiang L.	J Appl Microbiol	10.1111/jam.15387	2022
	Feedstock variability impacts the bioconversion of sugar and lignin streams derived from corn stover by Clostridium tyrobutyricum and engineered Pseudomonas putida.	Ruhl IA, Nelson RS, Katahira R, Kruger JS, Chen X, Haugen SJ, Ingraham MA, Woodworth SP, Alt H, Ramirez KJ, Peterson DJ, Ding L, Laible PD, Linger JG, Salvachua D.	Microb Biotechnol	10.1111/1751-7915.70006	2024
	Construction of a Microbial Consortium for the De Novo Synthesis of Butyl Butyrate from Renewable Resources.	Lu J, Jiang W, Dong W, Zhou J, Zhang W, Jiang Y, Xin F, Jiang M.	J Agric Food Chem	10.1021/acs.jafc.2c07650	2023
	Metabolic and Bioprocess Engineering of Clostridium tyrobutyricum for Butyl Butyrate Production on Xylose and Shrimp Shell Waste.	Wang H, Chen Y, Yang Z, Deng H, Liu Y, Wei P, Zhu Z, Jiang L.	Foods	10.3390/foods13071009	2024
	Improved Antimicrobial Properties of White Wastewater Protein Hydrolysate Through Electrodialysis with an Ultrafiltration Membrane (EDUF).	Damen D, Thibodeau J, Gaaloul S, Labrie S, Hamoudi S, Bazinet L.	Membranes (Basel)	10.3390/membranes15080238	2025
	Development of a risk assessment model to predict the occurrence of late blowing defect in Gouda cheese and evaluate potential intervention strategies.	Qian C, Martin NH, Wiedmann M, Trmcic A.	J Dairy Sci	10.3168/jds.2021-21206	2022
	Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: The effects of pretreatment method and heat shock protein overexpression.	Fu H, Hu J, Guo X, Feng J, Yang ST, Wang J.	Bioresour Technol	10.1016/j.biortech.2021.125290	2021
	Clostridium tyrobutyricum occurrence in silages and cattle feed: Use of molecular and simulation data to optimize predictive models.	Mosconi M, Fontana A, Daza MVB, Bassi D, Gallo A.	Front Microbiol	10.3389/fmicb.2023.1118646	2023
	Microbiome dysbiosis in patients with chronic endometritis and Clostridium tyrobutyricum ameliorates chronic endometritis in mice.	Liu J, Tang X, Chen L, Zhang Y, Gao J, Wang A.	Sci Rep	10.1038/s41598-024-63382-4	2024
	New insights into microbial interactions and putative competitive mechanisms during the hydrogen production from tequila vinasses.	Toledo-Cervantes A, Mendez-Acosta HO, Arreola-Vargas J, Gabriel-Barajas JE, Aguilar-Mota MN, Snell-Castro R.	Appl Microbiol Biotechnol	10.1007/s00253-022-12143-2	2022
Metabolism	Effects of Clostridium tyrobutyricum on Lipid Metabolism, Intestinal Barrier Function, and Gut Microbiota in Obese Mice Induced by High-Fat Diet.	Luo Y, Jin Y, Wang H, Wang G, Lin Y, Chen H, Li X, Wang M.	Nutrients	10.3390/nu16040493	2024
	The effect of Clostridium tyrobutyricum Spo0A overexpression in the intestine of mice.	Liang Q, Liu J, Wei J, Jia J, Shen H, Chen W, Liang W, Gao B, Xu Z, Zhang L.	Benef Microbes	10.3920/bm2019.0131	2020
	Draft Genome Sequences of 12 Clostridium tyrobutyricum Strains Isolated from Raw Milk and Cheese.	Podrzaj L, Burtscher J, Domig KJ.	Microbiol Resour Announc	10.1128/mra.00735-21	2021
Metabolism	Effects of benzyl viologen on increasing NADH availability, acetate assimilation, and butyric acid production by Clostridium tyrobutyricum.	Fu H, Lin M, Tang IC, Wang J, Yang ST.	Biotechnol Bioeng	10.1002/bit.27602	2021
Enzymology	Comparative transcriptome analysis of Clostridium tyrobutyricum expressing a heterologous uptake hydrogenase.	Li W, Cheng C, Cao G, Yang ST, Ren N.	Sci Total Environ	10.1016/j.scitotenv.2020.142022	2020
Metabolism	Recent advances in n-butanol and butyrate production using engineered Clostridium tyrobutyricum.	Bao T, Feng J, Jiang W, Fu H, Wang J, Yang ST.	World J Microbiol Biotechnol	10.1007/s11274-020-02914-2	2020
	Genome Sequence Analysis of Clostridium tyrobutyricum, a Promising Microbial Host for Human Health and Industrial Applications.	Liu T, Zhu L, Zhu Z, Jiang L.	Curr Microbiol	10.1007/s00284-020-02175-0	2020
	Exploring the aerobic stability, antioxidant and microbial community of Broussonetia papyrifera ensiled with ferulic acid esterase-producing Lactiplantibacillus plantarum in combination with cellulase and/or xylanase.	Long Y, Li M, Su Y, Yu Q, Rong Y, Xi Y, Sun H, Xie Y, Hao J, Chen C, Zheng Y, Yang F.	BMC Microbiol	10.1186/s12866-025-04185-z	2025
	Prokaryotic population dynamics and interactions in an AnSBBR using tequila vinasses as substrate in co-digestion with acid hydrolysates of Agave tequilana var. azul bagasse for hydrogen production.	Gabriel-Barajas JE, Arreola-Vargas J, Toledo-Cervantes A, Mendez-Acosta HO, Rivera-Gonzalez JC, Snell-Castro R.	J Appl Microbiol	10.1111/jam.15196	2022
Stress	Biofilm formation by heat-resistant dairy bacteria: multispecies biofilm model under static and dynamic conditions.	Diarra C, Goetz C, Gagnon M, Roy D, Jean J.	Appl Environ Microbiol	10.1128/aem.00713-23	2023
	Influences of food contaminants and additives on gut microbiota as well as protective effects of dietary bioactive compounds	Luo M, Zhou DD, Shang A, Gan RY, Li HB.	Trends in food science & technology.		2021
	Bioinformatics and metabolic flux analysis highlight a new mechanism involved in lactate oxidation in Clostridium tyrobutyricum.	Munier E, Licandro H, Beuvier E, Cachon R.	Int Microbiol	10.1007/s10123-022-00316-y	2023
	Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 19: Suitability of taxonomic units notified to EFSA until September 2023.	EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis K, Allende A, Alvarez-Ordonez A, Bolton D, Bover-Cid S, Chemaly M, De Cesare A, Hilbert F, Lindqvist R, Nauta M, Nonno R, Peixe L, Ru G, Simmons M, Skandamis P, Suffredini E, Cocconcelli PS, Fernandez Escamez PS, Prieto Maradona M, Querol A, Sijtsma L, Suarez JE, Sundh I, Barizzone F, Correia S, Herman L.	EFSA J	10.2903/j.efsa.2024.8517	2024
	Effect of acid based additive treatment of low dry matter grass crops on losses and silage quality in bunker silos	Randby AT, Bakken AK.	Anim Feed Sci Technol		2021
Genetics	Comparative Genomics Provides Insights Into Genetic Diversity of Clostridium tyrobutyricum and Potential Implications for Late Blowing Defects in Cheese.	Podrzaj L, Burtscher J, Domig KJ.	Front Microbiol	10.3389/fmicb.2022.889551	2022
Pathogenicity	Effect of Lactococcus lactis expressing phage endolysin on the late blowing defect of cheese caused by Clostridium tyrobutyricum.	Garde S, Calzada J, Sanchez C, Gaya P, Narbad A, Meijers R, Mayer MJ, Avila M.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2020.108686	2020
	Integrating chemical and biological catalysis for simultaneous production of polyphenolics and butyric acid from waste pomegranate peels.	Wang T, Zhao Q, Li C, He F, Jiang L, Aisa HA.	Sci Total Environ	10.1016/j.scitotenv.2021.146095	2021
	Evaluation of methods for DNA extraction from Clostridium tyrobutyricum spores and its detection by qPCR.	Esteban M, Marcos P, Horna C, Galan-Malo P, Mata L, Perez MD, Calvo M, Sanchez L.	J Microbiol Methods	10.1016/j.mimet.2019.105818	2020
Metabolism	Production of isopropyl and butyl esters by Clostridium mono-culture and co-culture.	Cui Y, He J, Yang KL, Zhou K.	J Ind Microbiol Biotechnol	10.1007/s10295-020-02279-3	2020
Metabolism	A heterogeneous microbial consortium producing short-chain fatty acids from lignocellulose.	Shahab RL, Brethauer S, Davey MP, Smith AG, Vignolini S, Luterbacher JS, Studer MH.	Science	10.1126/science.abb1214	2020
	Production of n-butanol from cassava bagasse hydrolysate by engineered Clostridium tyrobutyricum overexpressing adhE2: Kinetics and cost analysis.	Huang J, Du Y, Bao T, Lin M, Wang J, Yang ST.	Bioresour Technol	10.1016/j.biortech.2019.121969	2019
Metabolism	Development of an in vivo fluorescence based gene expression reporter system for Clostridium tyrobutyricum.	Cheng C, Lin M, Jiang W, Zhao J, Li W, Yang ST.	J Biotechnol	10.1016/j.jbiotec.2019.08.019	2019
	Correction to: Butanol and butyric acid production from Saccharina japonica by Clostridium acetobutylicum and Clostridium tyrobutyricum with adaptive evolution.	Ra CH, Sunwoo IY, Nguyen TH, Sukwong P, Sirisuk P, Jeong GT, Kim SK.	Bioprocess Biosyst Eng	10.1007/s00449-019-02145-2	2019
Enzymology	Colorimetric Point-of-Care Detection of Clostridium tyrobutyricum Spores in Milk Samples.	Cecere P, Gatto F, Cortimiglia C, Bassi D, Lucchini F, Cocconcelli PS, Pompa PP.	Biosensors (Basel)	10.3390/bios11090293	2021
Metabolism	Clostridium tyrobutyricum alleviates Staphylococcus aureus-induced endometritis in mice by inhibiting endometrial barrier disruption and inflammatory response.	Hu X, Guo J, Xu M, Jiang P, Yuan X, Zhao C, Maimai T, Cao Y, Zhang N, Fu Y.	Food Funct	10.1039/c9fo00654k	2019
Enzymology	Abatement of the clostridial load in the teats of lactating cows with lysozyme derived from donkey milk.	Adduci F, Elshafie HS, Labella C, Musto M, Freschi P, Paolino R, Ragni M, Cosentino C.	J Dairy Sci	10.3168/jds.2019-16311	2019
	Utilisation of Lactiplantibacillus plantarum and propionic acid to improve silage quality of amaranth before and after wilting: fermentation quality, microbial communities, and their metabolic pathway.	Zhao M, Bao J, Wang Z, Sun P, Liu J, Yan Y, Ge G.	Front Microbiol	10.3389/fmicb.2024.1415290	2024
	Lactobacillus plantarum and propionic acid improve the fermentation quality of high-moisture amaranth silage by altering the microbial community composition.	Zhao M, Wang Z, Du S, Sun L, Bao J, Hao J, Ge G.	Front Microbiol	10.3389/fmicb.2022.1066641	2022
	Fermentation Characteristics, Nutrient Content, and Microbial Population of Silphium perfoliatum L. Silage Produced with Different Lactic Acid Bacteria Additives.	Jin Y, Yuan B, Li F, Du J, Yu M, Tang H, Zhang L, Wang P.	Animals (Basel)	10.3390/ani15131955	2025
Metabolism	Butanol and butyric acid production from Saccharina japonica by Clostridium acetobutylicum and Clostridium tyrobutyricum with adaptive evolution.	Ra CH, Sunwoo IY, Nguyen TH, Sukwong P, Sirisuk P, Jeong GT, Kim SK.	Bioprocess Biosyst Eng	10.1007/s00449-018-02063-9	2019
Genetics	Characterizing microbial diversity and metabolic pathways in yak milk and fermented yak milk based on metagenomics: A study from Ganzi Tibetan autonomous prefecture.	Zhang J, Jiao Y, Liu K, Situ W, Menghe B, Chen Y, Zha M.	Food Chem X	10.1016/j.fochx.2025.102198	2025
Pathogenicity	Gut flora-derived succinate exacerbates Allergic Airway Inflammation by promoting protein succinylation.	Wang C, Yu X, Yu X, Xiao H, Song Y, Wang X, Zheng H, Chen K, An Y, Zhou Z, Guo X, Wang F.	Redox Biol	10.1016/j.redox.2025.103623	2025
	Losses and grass silage quality in bunker silos compacted by tractor versus wheel loader	Randby AT, Halvorsen HN, Bakken AK.	Anim Feed Sci Technol	10.1016/j.anifeedsci.2020.114523	2020
Enzymology	Dairy farm management practices and the risk of contamination of tank milk from Clostridium spp. and Paenibacillus spp. spores in silage, total mixed ration, dairy cow feces, and raw milk.	Borreani G, Ferrero F, Nucera D, Casale M, Piano S, Tabacco E.	J Dairy Sci	10.3168/jds.2019-16462	2019
Enzymology	One year investigation of the prevalence and diversity of clostridial spores in raw milk from the Tokachi area of Hokkaido.	Komori K, Ohkubo Y, Katano N, Motoshima H.	Anim Sci J	10.1111/asj.13135	2019
	Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice.	Jin X, Liu Y, Vallee I, Karadjian G, Liu M, Liu X.	Front Immunol	10.3389/fimmu.2022.926765	2022
Metabolism	Biosynthesis of butyric acid by Clostridium tyrobutyricum.	Huang J, Tang W, Zhu S, Du M.	Prep Biochem Biotechnol	10.1080/10826068.2018.1452257	2018
Metabolism	Use of fluorescent CTP1L endolysin cell wall-binding domain to study the evolution of Clostridium tyrobutyricum during cheese ripening.	Gomez-Torres N, Avila M, Narbad A, Mayer MJ, Garde S.	Food Microbiol	10.1016/j.fm.2018.09.018	2019
Metabolism	Clostridium Tyrobutyricum Protect Intestinal Barrier Function from LPS-Induced Apoptosis via P38/JNK Signaling Pathway in IPEC-J2 Cells.	Xiao Z, Liu L, Tao W, Pei X, Wang G, Wang M.	Cell Physiol Biochem	10.1159/000489364	2018
	Microbial valorization of solid wastes from a recirculating aquaculture system and the relevant microbial functions	Lee J, Kim IS, Emmanuel A, Koh SC.	Aquacultural engineering.	10.1016/j.aquaeng.2019.102016	2019
	High Performance of Biohydrogen Production in Packed-Filter Bioreactor via Optimizing Packed-Filter Position.	Chu CY, Zheng JL, Chen TH, Bhuyar P.	Int J Environ Res Public Health	10.3390/ijerph18147462	2021
	Spore-Forming Clostridia in Raw Cow Milk from Northern Italy: A Trend Analysis over the Past 20 Years.	Guaita A, Gambi L, Baresi P, Paterlini F, Bolzoni G, Zanardi G, Daminelli P.	Foods	10.3390/foods13223638	2024
	Dried Herbs as an Easy-to-Use and Cost-Effective Alternative to Essential Oils to Extend the Shelf Life of Sheep Lump Cheese.	Kunova S, Taglieri I, Hascik P, Ben Hsouna A, Mnif W, Venturi F, Sanmartin C, Cmikova N, Kluz MI, Kacaniova M.	Foods	10.3390/foods12244487	2023
Enzymology	Effect of hot season on blood parameters, fecal fermentative parameters, and occurrence of Clostridium tyrobutyricum spores in feces of lactating dairy cows.	Calamari L, Morera P, Bani P, Minuti A, Basirico L, Vitali A, Bernabucci U.	J Dairy Sci	10.3168/jds.2017-13693	2018
	One year investigation of the prevalence and diversity of clostridial spores in raw milk from the Tokachi area of Hokkaido	Komori K, Ohkubo Y, Katano N, Motoshima H.	Animal Science Journal.		2019
Metabolism	Exploiting endogenous CRISPR-Cas system for multiplex genome editing in Clostridium tyrobutyricum and engineer the strain for high-level butanol production.	Zhang J, Zong W, Hong W, Zhang ZT, Wang Y.	Metab Eng	10.1016/j.ymben.2018.03.007	2018
	Composition and distribution characteristics of acetic acid-related bacteria during the fermentation process of strong-flavor baijiu.	Mandlaa M, Liu M, Ren G, Qu H, Wang H, Ma F, Zhang M, Guo J, Chen Z, Sun Z.	Front Microbiol	10.3389/fmicb.2025.1603412	2025
	Cracking spoilage in jar cream cheese: Introducing, modeling and preventing.	Yolmeh M, Jafari SM.	Heliyon	10.1016/j.heliyon.2024.e25259	2024
Metabolism	Pretreatment with gamma-Valerolactone/[Mmim]DMP and Enzymatic Hydrolysis on Corncob and Its Application in Immobilized Butyric Acid Fermentation.	Zheng W, Liu X, Zhu L, Huang H, Wang T, Jiang L.	J Agric Food Chem	10.1021/acs.jafc.8b04323	2018
Enzymology	Improving sustainable hydrogen production from green waste: [FeFe]-hydrogenases quantitative gene expression RT-qPCR analysis in presence of autochthonous consortia.	Arizzi M, Morra S, Gilardi G, Pugliese M, Gullino ML, Valetti F.	Biotechnol Biofuels	10.1186/s13068-021-02028-3	2021
Genetics	Implementation of a Clostridium luticellarii genome-scale model for upgrading syngas fermentations.	Scott WT, Rockx S, Marien Q, Regueira A, Candry P, Ganigue R, Koehorst JJ, Schaap PJ.	Comput Struct Biotechnol J	10.1016/j.csbj.2025.01.013	2025
Metabolism	Effect of temperature on the microstructure of fat globules and the immunoglobulin-mediated interactions between fat and bacteria in natural raw milk creaming.	D'Incecco P, Ong L, Pellegrino L, Faoro F, Barbiroli A, Gras S.	J Dairy Sci	10.3168/jds.2017-13580	2018
	The late blowing defect of hard cheeses: Behaviour of cells and spores of Clostridium tyrobutyricum throughout the cheese manufacturing and ripening	D'Incecco P, Pellegrino L, Hogenboom JA, Cocconcelli PS, Bassi D.	Lebensm Wiss Technol	10.1016/j.lwt.2017.08.083	2018
	Study on the Effect of Key Genes ME2 and adhE during Luzhou-Flavor Baijiu Brewing.	Zhou W, Xia Y, Zhao Y, Wang Y, Wu Z, Suyama T, Zhang W.	Foods	10.3390/foods11050700	2022
Metabolism	Acetone-Butanol-Ethanol Production from Waste Seaweed Collected from Gwangalli Beach, Busan, Korea, Based on pH-Controlled and Sequential Fermentation Using Two Strains.	Sunwoo IY, Hau NT, Ra CH, Jeong GT, Kim SK.	Appl Biochem Biotechnol	10.1007/s12010-018-2711-9	2018
	Industrial-scale application of Lactobacillus reuteri coupled with glycerol as a biopreservation system for inhibiting Clostridium tyrobutyricum in semi-hard ewe milk cheese.	Avila M, Gomez-Torres N, Delgado D, Gaya P, Garde S.	Food Microbiol	10.1016/j.fm.2017.04.010	2017
Metabolism	n-Butanol production from sucrose and sugarcane juice by engineered Clostridium tyrobutyricum overexpressing sucrose catabolism genes and adhE2.	Zhang J, Yu L, Lin M, Yan Q, Yang ST.	Bioresour Technol	10.1016/j.biortech.2017.02.079	2017
Metabolism	Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization.	Fu H, Yang ST, Wang M, Wang J, Tang IC.	Bioresour Technol	10.1016/j.biortech.2017.03.073	2017
	The effect of autochthonous caproic acid-producing consortia inoculation on the multi-dimensional prokaryotic succession of bottom pitmud used for the Chinese strong-flavor Baijiu fermentation.	Zhang H, Zhen L, Chang Q, Liu Y, Xu K, Wang X, Cui L, Wu Z, Xue Z.	Curr Res Microb Sci	10.1016/j.crmicr.2025.100490	2025
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice.	Zhang J, Yu L, Xu M, Yang ST, Yan Q, Lin M, Tang IC.	Appl Microbiol Biotechnol	10.1007/s00253-017-8200-1	2017
Pathogenicity	Periodontitis associated with Porphyromonas gingivalis infection is a risk factor for infertility through uterine hypertrophy.	Kamei-Nagata C, Omori K, Sako H, Sakaida K, Nakayama MA, Ohara T, Mandai H, Kubota-Takamori M, Kiyama F, Ishii T, Hirai K, Ikeda A, Takeuchi-Hatanaka K, Shinoda-Ito Y, Tai-Tokuzen M, Sakamoto A, Kiyokawa M, Yamanishi T, Oda T, Takigawa M, Yamamoto T, Miyake T, Takashiba S.	Sci Rep	10.1038/s41598-025-18992-x	2025
Genetics	Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications.	Wu Q, Liu T, Zhu L, Huang H, Jiang L.	J Ind Microbiol Biotechnol	10.1007/s10295-017-1956-6	2017
Enzymology	Proteomics Parameters for Assessing Authenticity of Grated Grana Padano PDO Cheese: Results from a Three-Year Survey.	Pellegrino L, Rosi V, Sindaco M, D'Incecco P.	Foods	10.3390/foods13030355	2024
Pathogenicity	Human gut microbes are susceptible to antimicrobial food additives in vitro.	Hrncirova L, Hudcovic T, Sukova E, Machova V, Trckova E, Krejsek J, Hrncir T.	Folia Microbiol (Praha)	10.1007/s12223-018-00674-z	2019
Metabolism	The study of the relationship between food additives and the childhood asthma based on metabolome analysis.	Chen M, Xu X, Jiang X, Hui J, Tao X, Bao Y, Cao S, Wu Q.	Front Immunol	10.3389/fimmu.2025.1671022	2025
Metabolism	A Potential Probiotic for Diarrhea: Clostridium tyrobutyricum Protects Against LPS-Induced Epithelial Dysfunction via IL-22 Produced By Th17 Cells in the Ileum.	Xiao Z, Liu L, Pei X, Sun W, Jin Y, Yang ST, Wang M.	Front Immunol	10.3389/fimmu.2021.758227	2021
	Concurrence of spores of Clostridium tyrobutyricum, Clostridium beijerinckii and Paenibacillus polymyxa in silage, dairy cow faeces and raw milk	Driehuis F, Hoolwerf J, Rademaker JLW.	Int Dairy J	10.1016/j.idairyj.2016.08.004	2016
Metabolism	Carbon material distribution and flux analysis under varying glucose concentrations in hydrogen-producing Clostridium tyrobutyricum JM1.	Jo JH, Kim W.	J Biotechnol	10.1016/j.jbiotec.2016.04.051	2016
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose.	Fu H, Yu L, Lin M, Wang J, Xiu Z, Yang ST.	Metab Eng	10.1016/j.ymben.2016.12.014	2017
	Application of high pressure processing for controlling Clostridium tyrobutyricum and late blowing defect on semi-hard cheese.	Avila M, Gomez-Torres N, Delgado D, Gaya P, Garde S.	Food Microbiol	10.1016/j.fm.2016.07.008	2016
Metabolism	Clostridium tyrobutyricum Protects against LPS-Induced Colonic Inflammation via IL-22 Signaling in Mice.	Xiao Z, Liu L, Jin Y, Pei X, Sun W, Wang M.	Nutrients	10.3390/nu13010215	2021
Enzymology	Enhancing Bacillus cereus antibacterial ability through improved cofactor supply.	Xu Y, Wu J, Yuan T, Chen Z, Feng D, Yang P, Han L, Geng L, Hu J, Wang G.	Microb Cell Fact	10.1186/s12934-025-02666-4	2025
Metabolism	Adaptability of a Caproate-Producing Bacterium Contributes to Its Dominance in an Anaerobic Fermentation System.	Wang H, Gu Y, Zhou W, Zhao D, Qiao Z, Zheng J, Gao J, Chen X, Ren C, Xu Y.	Appl Environ Microbiol	10.1128/aem.01203-21	2021
	Enhanced production of butyric acid through immobilization of Clostridium tyrobutyricum in a novel inner disc-shaped matrix bioreactor	Huang J, Dai H, Ma S, Wang P.	Ann Microbiol	10.1007/s13213-015-1088-z	2016
	Kinetic study of the thermal inactivation of Weizmannia coagulans during food thermal processing.	Peng S, Guo C, Zhang X, Bu X, Li X, Cui H, Duan Z.	Heliyon	10.1016/j.heliyon.2024.e36977	2024
	Low-Level Clostridial Spores' Milk to Limit the Onset of Late Blowing Defect in Lysozyme-Free, Grana-Type Cheese.	Carminati D, Bonvini B, Francolino S, Ghiglietti R, Locci F, Tidona F, Mariut M, Abeni F, Zago M, Giraffa G.	Foods	10.3390/foods12091880	2023
Biotechnology	Genomic approach to studying nutritional requirements of Clostridium tyrobutyricum and other Clostridia causing late blowing defects.	Storari M, Kulli S, Wuthrich D, Bruggmann R, Berthoud H, Arias-Roth E.	Food Microbiol	10.1016/j.fm.2016.05.013	2016
	Production of butyric acid by Clostridium tyrobutyricum (ATCC25755) using sweet sorghum stalks and beet molasses	Sjoblom M, Matsakas L, Christakopoulos P, Rova U.	Industrial crops and products.	10.1016/j.indcrop.2015.05.041	2015
	Microbiome profiling of Grana Padano and Parmigiano Reggiano cheeses reveals cheese-specific biomarkers, psychobiotic potential, and bioprotective activities.	Valentino V, Magliulo R, Balivo A, Krysmann AM, Calvanese CM, Esposito A, Sequino G, Genovese A, Porcellato D, Ercolini D, De Filippis F.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00815-6	2025
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production through co-utilization of glucose and xylose.	Yu L, Xu M, Tang IC, Yang ST.	Biotechnol Bioeng	10.1002/bit.25613	2015
Biotechnology	A Systematic Review on Microbial Profiling Techniques in Goat Milk: Implications for Probiotics and Shelf-Life.	Monareng NJ, Ncube KT, van Rooi C, Modiba MC, Mtileni B.	Int J Mol Sci	10.3390/ijms26125551	2025
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from maltose and soluble starch by overexpressing alpha-glucosidase.	Yu L, Xu M, Tang IC, Yang ST.	Appl Microbiol Biotechnol	10.1007/s00253-015-6680-4	2015
Metabolism	Exploring the microbial origins of p-cresol and its co-occurrence pattern in the Chinese liquor-making process.	Du H, Liu B, Wang X, Xu Y.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2017.08.016	2017
	Microbial community dynamics during alfalfa silage with or without clostridial fermentation.	Li R, Jiang D, Zheng M, Tian P, Zheng M, Xu C.	Sci Rep	10.1038/s41598-020-74958-1	2020
Phylogeny	Development of a triplex real-time PCR assay for the simultaneous detection of Clostridium beijerinckii, Clostridium sporogenes and Clostridium tyrobutyricum in milk.	Morandi S, Cremonesi P, Silvetti T, Castiglioni B, Brasca M.	Anaerobe	10.1016/j.anaerobe.2015.04.005	2015
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production: effects of CoA transferase.	Yu L, Zhao J, Xu M, Dong J, Varghese S, Yu M, Tang IC, Yang ST.	Appl Microbiol Biotechnol	10.1007/s00253-015-6566-5	2015
Metabolism	Mechanisms of Clostridium tyrobutyricum removal through natural creaming of milk: A microscopy study.	D'Incecco P, Faoro F, Silvetti T, Schrader K, Pellegrino L.	J Dairy Sci	10.3168/jds.2015-9526	2015
	CRISPR-Cas-Based Engineering of Probiotics.	Liu L, Helal SE, Peng N.	Biodes Res	10.34133/bdr.0017	2023
Metabolism	Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis.	Yang Q, Guo S, Lu Q, Tao Y, Zheng D, Zhou Q, Liu J.	Biosci Rep	10.1042/bsr20211135	2021
Enzymology	Seasonal occurrence and molecular diversity of clostridia species spores along cheesemaking streams of 5 commercial dairy plants.	Bermudez J, Gonzalez MJ, Olivera JA, Burgueno JA, Juliano P, Fox EM, Reginensi SM.	J Dairy Sci	10.3168/jds.2015-10079	2016
	Pathogenicity and Antibiotic Resistance Diversity in Clostridium perfringens Isolates from Poultry Affected by Necrotic Enteritis in Canada.	Garcia-Vela S, Martinez-Sancho A, Said LB, Torres C, Fliss I.	Pathogens	10.3390/pathogens12070905	2023
Metabolism	High-efficient n-butanol production by co-culturing Clostridium acetobutylicum and Saccharomyces cerevisiae integrated with butyrate fermentative supernatant addition.	Luo H, Zeng Q, Han S, Wang Z, Dong Q, Bi Y, Zhao Y.	World J Microbiol Biotechnol	10.1007/s11274-017-2246-1	2017
Metabolism	Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum.	Ma C, Kojima K, Xu N, Mobley J, Zhou L, Yang ST, Liu XM.	J Biotechnol	10.1016/j.jbiotec.2014.10.036	2015
	Effect of high-pressure treatments on proteolysis, volatile compounds, texture, colour, and sensory characteristics of semi-hard raw ewe milk cheese.	Avila M, Gomez-Torres N, Delgado D, Gaya P, Garde S.	Food Res Int	10.1016/j.foodres.2017.07.043	2017
	Dynamics of microbial community during ensiling direct-cut alfalfa with and without LAB inoculant and sugar.	Zheng ML, Niu DZ, Jiang D, Zuo SS, Xu CC.	J Appl Microbiol	10.1111/jam.13456	2017
	Microbial Community Affects Daqu Quality and the Production of Ethanol and Flavor Compounds in Baijiu Fermentation.	Han PJ, Luo LJ, Han Y, Song L, Zhen P, Han DY, Wei YH, Zhou X, Wen Z, Qiu JZ, Bai FY.	Foods	10.3390/foods12152936	2023
	Co-ensiling pomegranate (Punica granatum L.) peels and molasses with berseem (Trifolium alexandrinum L.) alters fermentation quality, nutrient composition, ruminal fermentation and methane production in buffalo bulls in-vitro.	Ahmed MG, El-Zarkouny SZ, Al-Sagheer AA, Elwakeel EA.	Trop Anim Health Prod	10.1007/s11250-024-04259-6	2025
Phylogeny	Detection of the Microbial Composition of Some Commercial Fermented Liquid Products via Metagenomic Analysis.	Celik Dogan C, Yuksel Dolgun HT, Ikiz S, Kirkan S, Parin U.	Foods	10.3390/foods12193538	2023
	Effects of different heat treatments on lysozyme quantity and antimicrobial activity of jenny milk.	Cosentino C, Labella C, Elshafie HS, Camele I, Musto M, Paolino R, D'Adamo C, Freschi P.	J Dairy Sci	10.3168/jds.2015-10702	2016
Metabolism	Comparison of the effects of high energy carbon heavy ion irradiation and Eucommia ulmoides Oliv. on biosynthesis butyric acid efficiency in Clostridium tyrobutyricum.	Zhou X, Wang SY, Lu XH, Liang JP.	Bioresour Technol	10.1016/j.biortech.2014.03.039	2014
	Draft Genome Sequence of Clostridium tyrobutyricum Strain DIVETGP, Isolated from Cow's Milk for Grana Padano Production.	Soggiu A, Piras C, Gaiarsa S, Bendixen E, Panitz F, Bendixen C, Sassera D, Brasca M, Bonizzi L, Roncada P.	Genome Announc	10.1128/genomea.00213-15	2015
	Application of exogenous electron mediator in fermentation to enhance the production of value-added products.	Yu Y, Shi Z, Li W, Bian M, Cheng C, Xi Y, Yao S, Zeng X, Jia Y.	Appl Environ Microbiol	10.1128/aem.00495-25	2025
	TaqMan real time-quantitative PCR targeting the phosphotransacetylase gene for Clostridium tyrobutyricum quantification in animal feed, faeces, milk and cheese	Bassi D, Fontana C, Zucchelli S, Gazzola S, Cocconcelli PS.	Int Dairy J	10.1016/j.idairyj.2013.06.008	2013
Pathogenicity	New Antibacterial Peptides from the Freshwater Mollusk Pomacea poeyana (Pilsbry, 1927).	Gonzalez Garcia M, Rodriguez A, Alba A, Vazquez AA, Morales Vicente FE, Perez-Erviti J, Spellerberg B, Stenger S, Grieshober M, Conzelmann C, Munch J, Raber H, Kubiczek D, Rosenau F, Wiese S, Standker L, Otero-Gonzalez A.	Biomolecules	10.3390/biom10111473	2020
Genetics	Hi-TARGET: a fast, efficient and versatile CRISPR type I-B genome editing tool for the thermophilic acetogen Thermoanaerobacter kivui.	Sitara A, Hocq R, Lu AJ, Pflugl S.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02647-0	2025
	The gut microbiota is important for the maintenance of blood-cerebrospinal fluid barrier integrity.	Knox EG, Lynch CMK, Lee YS, O'Driscoll CM, Clarke G, Cryan JF, Aburto MR.	Eur J Neurosci	10.1111/ejn.15878	2023
Biotechnology	Detection of Clostridium tyrobutyricum in milk to prevent late blowing in cheese by automated ribosomal intergenic spacer analysis.	Panelli S, Brambati E, Bonacina C, Feligini M.	J Food Sci	10.1111/1750-3841.12229	2013
Metabolism	Lysozyme affects the microbial catabolism of free arginine in raw-milk hard cheeses.	D'Incecco P, Gatti M, Hogenboom JA, Bottari B, Rosi V, Neviani E, Pellegrino L.	Food Microbiol	10.1016/j.fm.2015.11.020	2016
	Draft Genome Sequences of Clostridium tyrobutyricum Strains FAM22552 and FAM22553, Isolated from Swiss Semihard Red-Smear Cheese.	Storari M, Wuthrich D, Bruggmann R, Berthoud H, Arias-Roth E.	Genome Announc	10.1128/genomea.00078-15	2015
Metabolism	Enhanced isopropanol and n-butanol production by supplying exogenous acetic acid via co-culturing two clostridium strains from cassava bagasse hydrolysate.	Zhang S, Qu C, Huang X, Suo Y, Liao Z, Wang J.	J Ind Microbiol Biotechnol	10.1007/s10295-016-1775-1	2016
	Histological and electroencephalographic demonstration of probiotic effect for reduce of oxidative stress and apoptosis in experimental traumatic brain injury.	Karakayali EM, Kocamaz E, Alpay S, Onal T, Oztatlici M, Durusma R, Ozel HF, Mete M, Barutcuoglu M, Kutlu N, Tuglu MI.	Ulus Travma Acil Cerrahi Derg	10.14744/tjtes.2023.80743	2023
	Carboxylic Acid Concentration in Downstream Bioprocessing Using High-Pressure Reverse Osmosis.	Chen Y, Olcay H, Tan ECD, Woodworth SP, Miscall J, Aromolaran A, Saboe PO, Linger JG, Beckham GT.	ACS Sustain Chem Eng	10.1021/acssuschemeng.4c10709	2025
	Pretreatment of Corn Stover by Low Moisture Anhydrous Ammonia (LMAA) in a Pilot-Scale Reactor and Bioconversion to Fuel Ethanol and Industrial Chemicals.	Nghiem NP, Senske GE, Kim TH.	Appl Biochem Biotechnol	10.1007/s12010-016-1982-2	2016
Genetics	Multi-omics analysis reveals the core microbiome and biomarker for nutrition degradation in alfalfa silage fermentation.	Wang Y, Sun Y, Huang K, Gao Y, Lin Y, Yuan B, Wang X, Xu G, Nussio LG, Yang F, Ni K.	mSystems	10.1128/msystems.00682-24	2024
Metabolism	Metabolic flux network analysis of fermentative hydrogen production: using Clostridium tyrobutyricum as an example.	Cheng HH, Whang LM, Lin CA, Liu IC, Wu CW.	Bioresour Technol	10.1016/j.biortech.2013.03.141	2013
Metabolism	Demonstration of in situ product recovery of butyric acid via CO2 -facilitated pH swings and medium development in two-phase partitioning bioreactors.	Peterson EC, Daugulis AJ.	Biotechnol Bioeng	10.1002/bit.25106	2014
	Propionic Acid and Sodium Benzoate Affected Biogenic Amine Formation, Microbial Community, and Quality of Oat Silage.	Jia T, Yun Y, Yu Z.	Front Microbiol	10.3389/fmicb.2021.750920	2021
	Development of a Magnetic Bead-Based Method for Specific Detection of Enterococcus faecalis Using C-Terminal Domain of ECP3 Phage Endolysin.	Choi YJ, Kim S, Kim J.	J Microbiol Biotechnol	10.4014/jmb.2302.02033	2023
Metabolism	Enhanced butanol production by coculture of Clostridium beijerinckii and Clostridium tyrobutyricum.	Li L, Ai H, Zhang S, Li S, Liang Z, Wu ZQ, Yang ST, Wang JF.	Bioresour Technol	10.1016/j.biortech.2013.06.023	2013
Enzymology	Understanding the bacterial communities of hard cheese with blowing defect.	Bassi D, Puglisi E, Cocconcelli PS.	Food Microbiol	10.1016/j.fm.2015.07.004	2015
Enzymology	Heterologous expression and purification of the phage lysin-like bacteriocin LysL from Lactococcus lactis LAC460.	Mokhtari S, Saris PEJ, Takala TM.	FEMS Microbiol Lett	10.1093/femsle/fnae065	2024
Metabolism	Engineered strains of Streptococcus macedonicus towards an osmotic stress resistant phenotype retain their ability to produce the bacteriocin macedocin under hyperosmotic conditions.	Anastasiou R, Driessche GV, Boutou E, Kazou M, Alexandraki V, Vorgias CE, Devreese B, Tsakalidou E, Papadimitriou K.	J Biotechnol	10.1016/j.jbiotec.2015.08.018	2015
Metabolism	Butyric acid production from sugarcane bagasse hydrolysate by Clostridium tyrobutyricum immobilized in a fibrous-bed bioreactor.	Wei D, Liu X, Yang ST.	Bioresour Technol	10.1016/j.biortech.2012.11.065	2013
	Clostridium tyrobutyricum strains show wide variation in growth at different NaCl, pH, and temperature conditions.	Ruusunen M, Surakka A, Korkeala H, Lindstrom M.	J Food Prot	10.4315/0362-028x.jfp-12-109	2012
Genetics	Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota.	Xi M, Yan Y, Duan S, Li T, Szeto IM, Zhao A.	Front Microbiol	10.3389/fmicb.2024.1356462	2024
	Volatile Transference and Antimicrobial Activity of Cheeses Made with Ewes' Milk Fortified with Essential Oils.	Licon CC, Moro A, Libran CM, Molina AM, Zalacain A, Berruga MI, Carmona M.	Foods	10.3390/foods9010035	2020
	Effects of xylanase, protease, and xylo-oligosaccharides on growth performance, nutrient utilization, short chain fatty acids, and microbiota in Eimeria-challenged broiler chickens fed high fiber diet.	Lin Y, Lourenco JM, Olukosi OA.	Anim Nutr	10.1016/j.aninu.2023.08.009	2023
	Dynamic Changes in Fermentation Quality and Structure and Function of the Microbiome during Mixed Silage of Sesbania cannabina and Sweet Sorghum Grown on Saline-Alkaline Land.	Wang T, Zhang J, Shi W, Sun J, Xia T, Huang F, Liu Y, Li H, Teng K, Zhong J.	Microbiol Spectr	10.1128/spectrum.02483-22	2022
	Illuminating the Characteristics and Assembly of Prokaryotic Communities across a pH Gradient in Pit Muds for the Production of Chinese Strong-Flavor Baijiu.	Deng M, Hu X, Zhang Y, Zhang X, Ni H, Fu D, Chi L.	Foods	10.3390/foods13081196	2024
Metabolism	Butyrate production enhancement by Clostridium tyrobutyricum using electron mediators and a cathodic electron donor.	Choi O, Um Y, Sang BI.	Biotechnol Bioeng	10.1002/bit.24520	2012
	Investigating Structural Defects in Extra Hard Cheese Produced from Low-Temperature Centrifugation of Milk.	Bettera L, Alinovi M, D'Incecco P, Gatti M, Carini E, Pellegrino L, Bancalari E.	Foods	10.3390/foods12173302	2023
Metabolism	Electrochemical detoxification of phenolic compounds in lignocellulosic hydrolysate for Clostridium fermentation.	Lee KM, Min K, Choi O, Kim KY, Woo HM, Kim Y, Han SO, Um Y.	Bioresour Technol	10.1016/j.biortech.2015.03.129	2015
Metabolism	ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways.	Korecka A, de Wouters T, Cultrone A, Lapaque N, Pettersson S, Dore J, Blottiere HM, Arulampalam V.	Am J Physiol Gastrointest Liver Physiol	10.1152/ajpgi.00293.2012	2013
Pathogenicity	Potential application of aromatic plant extracts to prevent cheese blowing.	Libran CM, Moro A, Zalacain A, Molina A, Carmona M, Berruga MI.	World J Microbiol Biotechnol	10.1007/s11274-013-1280-x	2013
	Mixotrophic chain elongation with syngas and lactate as electron donors.	Baleeiro FCF, Raab J, Kleinsteuber S, Neumann A, Strauber H.	Microb Biotechnol	10.1111/1751-7915.14163	2023
Metabolism	Metabolic engineering of Clostridium acetobutylicum for enhanced production of butyric acid.	Jang YS, Woo HM, Im JA, Kim IH, Lee SY.	Appl Microbiol Biotechnol	10.1007/s00253-013-5161-x	2013
Biotechnology	Development of a High-Throughput Microfluidic qPCR System for the Quantitative Determination of Quality-Relevant Bacteria in Cheese.	Dreier M, Berthoud H, Shani N, Wechsler D, Junier P.	Front Microbiol	10.3389/fmicb.2020.619166	2020
Enzymology	Incidence, diversity and characteristics of spores of psychrotolerant spore formers in various REPFEDS produced in Belgium.	Samapundo S, Devlieghere F, Xhaferi R, Heyndrickx M.	Food Microbiol	10.1016/j.fm.2014.06.020	2014
	Effect of invasive slug populations (Arion vulgaris) on grass silage. II: Microbiological quality and feed safety	Gismervik K, Randby AT, Rorvik LM, Bruheim T, Andersen A, Hernandez M, Skaar I.	Anim Feed Sci Technol	10.1016/j.anifeedsci.2014.09.024	2015
Pathogenicity	Endometrial responses to bacterial and viral infection: a scoping review.	Lindsay CV, Potter JA, Grimshaw AA, Abrahams VM, Tong M.	Hum Reprod Update	10.1093/humupd/dmad013	2023
Metabolism	Adaptive evolution for fast growth on glucose and the effects on the regulation of glucose transport system in Clostridium tyrobutyricum.	Jiang L, Li S, Hu Y, Xu Q, Huang H.	Biotechnol Bioeng	10.1002/bit.23346	2012
Enzymology	Enumeration of clostridia in goat milk using an optimized membrane filtration technique.	Reindl A, Dzieciol M, Hein I, Wagner M, Zangerl P.	J Dairy Sci	10.3168/jds.2014-8218	2014
Pathogenicity	New possibilities for egg white lysozyme: heat-denatured lysozyme partially inactivates select foot-and-mouth disease virus strains.	Fukai K, Inoue K, Takeuchi A, Yamakawa M.	Sci Rep	10.1038/s41598-020-80239-8	2021
Enzymology	Specific peptides as alternative to antibody ligands for biomagnetic separation of Clostridium tyrobutyricum spores.	Lavilla M, Moros M, Puertas S, Grazu V, Perez MD, Calvo M, de la Fuente JM, Sanchez L.	Anal Bioanal Chem	10.1007/s00216-011-5621-z	2012
	Production of Tetramethylpyrazine from Cane Molasses by Bacillus sp. TTMP20.	Li Y, Luo L, Ding X, Zhang X, Gan S, Shang C.	Molecules	10.3390/molecules28062640	2023
	Production of butyric acid from acid hydrolysate of corn husk in fermentation by Clostridium tyrobutyricum: kinetics and process economic analysis.	Xiao Z, Cheng C, Bao T, Liu L, Wang B, Tao W, Pei X, Yang ST, Wang M.	Biotechnol Biofuels	10.1186/s13068-018-1165-1	2018
Biotechnology	Management practices and forage quality affecting the contamination of milk with anaerobic spore-forming bacteria.	Zucali M, Bava L, Colombini S, Brasca M, Decimo M, Morandi S, Tamburini A, Crovetto GM.	J Sci Food Agric	10.1002/jsfa.6822	2015
	Production of biological hydrogen from Quinoa residue using dark fermentation and estimation of its microbial diversity.	Dursun N.	Heliyon	10.1016/j.heliyon.2024.e25018	2024
	A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia.	Asare PT, Lee CH, Hurlimann V, Teo Y, Cuenod A, Akduman N, Gekeler C, Afrizal A, Corthesy M, Kohout C, Thomas V, de Wouters T, Greub G, Clavel T, Pamer EG, Egli A, Maier L, Vonaesch P.	Front Microbiol	10.3389/fmicb.2023.1104707	2023
Metabolism	Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-alpha and interleukin-18 in BALB/c and severe combined immunodeficiency mice.	Hudcovic T, Kolinska J, Klepetar J, Stepankova R, Rezanka T, Srutkova D, Schwarzer M, Erban V, Du Z, Wells JM, Hrncir T, Tlaskalova-Hogenova H, Kozakova H.	Clin Exp Immunol	10.1111/j.1365-2249.2011.04498.x	2012
	Engineering the Marine Pseudoalteromonas haloplanktis TAC125 via the pMEGA Plasmid Targeted Curing Using PTasRNA Technology.	Severino A, Lauro C, Calvanese M, Riccardi C, Colarusso A, Fondi M, Parrilli E, Tutino ML.	Microorganisms	10.3390/microorganisms13020324	2025
	Immunological response in egg-sensitive adults challenged with cheese containing or not containing lysozyme.	Rossi F, Iaconelli A, Fiorentini L, Zito F, Donati MB, De Cristofaro ML, Piva G, Mingrone G.	J Am Coll Nutr	10.1080/07315724.2012.10720463	2012
Pathogenicity	Lactobacillus plantarum KAD protects against high-fat diet-induced hepatic complications in Swiss albino mice: Role of inflammation and gut integrity.	Ghosh S, Ghosh AJ, Islam R, Sarkar S, Saha T.	PLoS One	10.1371/journal.pone.0313548	2024
Pathogenicity	Metabolic and energetic aspects of biohydrogen production of Clostridium tyrobutyricum: The effects of hydraulic retention time and peptone addition.	Whang LM, Lin CA, Liu IC, Wu CW, Cheng HH.	Bioresour Technol	10.1016/j.biortech.2011.03.101	2011
Metabolism	Effects of dairy slurry on silage fermentation characteristics and nutritive value of alfalfa.	Coblentz WK, Muck RE, Borchardt MA, Spencer SK, Jokela WE, Bertram MG, Coffey KP.	J Dairy Sci	10.3168/jds.2014-8582	2014
	Nanomechanical analysis of Clostridium tyrobutyricum spores.	Andreeva N, Bassi D, Cappa F, Cocconcelli PS, Parmigiani F, Ferrini G.	Micron	10.1016/j.micron.2010.07.006	2010
	Microbial network and fermentation modulation of Napier grass and sugarcane top silage in southern Africa.	Du Z, Yamasaki S, Oya T, Nguluve D, Euridse D, Tinga B, Macome F, Cai Y.	Microbiol Spectr	10.1128/spectrum.03032-23	2024
Metabolism	Enhanced butyric acid tolerance and bioproduction by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor.	Jiang L, Wang J, Liang S, Cai J, Xu Z, Cen P, Yang S, Li S.	Biotechnol Bioeng	10.1002/bit.22927	2011
	Responses of microbial community dynamics, co-occurrences, functional shifts, and natural fermentation profiles of Elymus nutans silage to altitudinal gradients.	Su R, Li F, Liang Y, Sheoran N, Bai J, Hao L, Ke W, Hu C, Jia M, Usman S, Chen M, Guo X.	Microbiol Spectr	10.1128/spectrum.02516-23	2024
Metabolism	Efficient production of butyric acid from Jerusalem artichoke by immobilized Clostridium tyrobutyricum in a fibrous-bed bioreactor.	Huang J, Cai J, Wang J, Zhu X, Huang L, Yang ST, Xu Z.	Bioresour Technol	10.1016/j.biortech.2010.11.112	2011
Genetics	Genomic Characterization of Sulphite Reducing Bacteria Isolated From the Dairy Production Chain.	Doyle CJ, O'Toole PW, Cotter PD.	Front Microbiol	10.3389/fmicb.2018.01507	2018
Metabolism	Effects of copper on germination, growth and sporulation of Clostridium tyrobutyricum.	Mato Rodriguez L, Alatossava T.	Food Microbiol	10.1016/j.fm.2010.01.003	2010
Metabolism	[Engineering and metabolic characteristics of a Clostridium tyrobutyricum strain].	Yang G, Liu G, Yang C.	Sheng Wu Gong Cheng Xue Bao		2010
Enzymology	Selection of high affine peptide ligands for detection of Clostridium Tyrobutyricum spores.	Lavilla M, De Luis R, Perez MD, Calvo M, Sanchez L.	J Microbiol Methods	10.1016/j.mimet.2009.09.008	2009
Metabolism	nZVI Impacts Substrate Conversion and Microbiome Composition in Chain Elongation From D- and L-Lactate Substrates.	Contreras-Davila CA, Esveld J, Buisman CJN, Strik DPBTB.	Front Bioeng Biotechnol	10.3389/fbioe.2021.666582	2021
Enzymology	Biotechnological and safety characterization of Enterococcus lactis, a recently described species of dairy origin.	Morandi S, Silvetti T, Brasca M.	Antonie Van Leeuwenhoek	10.1007/s10482-012-9806-z	2013
	Energy-efficient recovery of fermented butyric acid using octyl acetate extraction.	Oh HW, Lee SC, Woo HC, Kim YH.	Biotechnol Biofuels Bioprod	10.1186/s13068-022-02146-6	2022
	Exploring the microbiota-gut-brain axis: impact on brain structure and function.	Yassin LK, Nakhal MM, Alderei A, Almehairbi A, Mydeen AB, Akour A, Hamad MIK.	Front Neuroanat	10.3389/fnana.2025.1504065	2025
	Microbiome mapping in dairy industry reveals new species and genes for probiotic and bioprotective activities.	De Filippis F, Valentino V, Yap M, Cabrera-Rubio R, Barcenilla C, Carlino N, Cobo-Diaz JF, Quijada NM, Calvete-Torre I, Ruas-Madiedo P, Sabater C, Sequino G, Pasolli E, Wagner M, Margolles A, Segata N, Alvarez-Ordonez A, Cotter PD, Ercolini D.	NPJ Biofilms Microbiomes	10.1038/s41522-024-00541-5	2024
Enzymology	A (S)-3-Hydroxybutyrate Dehydrogenase Belonging to the 3-Hydroxyacyl-CoA Dehydrogenase Family Facilitates Hydroxyacid Degradation in Anaerobic Bacteria.	Zhou Y, Wei Y, Jiang L, Zhang Y, Jiao X.	Appl Environ Microbiol	10.1128/aem.00366-23	2023
	Effect of in situ acids removal on mixed glucose and xylose fermentation by Clostridium tyrobutyricum.	Baroi GN, Skiadas IV, Westermann P, Gavala HN.	AMB Express	10.1186/s13568-015-0153-0	2015
Biotechnology	Detection of Clostridium tyrobutyricum spores using polyclonal antibodies and flow cytometry.	Lavilla M, Marzo I, de Luis R, Perez MD, Calvo M, Sanchez L.	J Appl Microbiol	10.1111/j.1365-2672.2009.04435.x	2010
Metabolism	Fermentative biohydrogen production from lactate and acetate.	Wu CW, Whang LM, Cheng HH, Chan KC.	Bioresour Technol	10.1016/j.biortech.2011.12.130	2012
Metabolism	A two-stage bioprocess for hydrogen and methane production from rice straw bioethanol residues.	Cheng HH, Whang LM, Wu CW, Chung MC.	Bioresour Technol	10.1016/j.biortech.2011.12.103	2012
Phylogeny	Microbiological Characterization of Actinotignum schaalii Strains Causing Invasive Infections during a Multiyear Period in a Large Canadian Health Care Region.	Lieu A, Mah J, Peirano G, Somayaji R, Church D.	Microbiol Spectr	10.1128/spectrum.03442-22	2022
	A combination of a SEM technique and X-ray microanalysis for studying the spore germination process of Clostridium tyrobutyricum.	Bassi D, Cappa F, Cocconcelli PS.	Res Microbiol	10.1016/j.resmic.2009.04.003	2009
	Inhibition of Clostridium tyrobutyricum by Streptococcus macedonicus ACA-DC 198 under conditions mimicking Kasseri cheese production and ripening	Anastasiou R, Aktypis A, Georgalaki M, Papadelli M, Vuyst Ld, Tsakalidou E.	Int Dairy J	10.1016/j.idairyj.2008.12.001	2009
Metabolism	Butyric acid fermentation in a fibrous bed bioreactor with immobilized Clostridium tyrobutyricum from cane molasses.	Jiang L, Wang J, Liang S, Wang X, Cen P, Xu Z.	Bioresour Technol	10.1016/j.biortech.2009.02.032	2009
	Inhibitory Effect of Lactiplantibacillusplantarum and Lactococcus lactis Autochtonous Strains against Listeria monocytogenes in a Laboratory Cheese Model.	Pisano MB, Fadda ME, Viale S, Deplano M, Mereu F, Blazic M, Cosentino S.	Foods	10.3390/foods11050715	2022
	Use of the E-beam radiation to diminish the late blowing of cheese	Velasco R, Ordonez JA, Cabeza MC, de la Hoz L, Cambero MI.	Int Dairy J	10.1016/j.idairyj.2011.01.011	2011
Biotechnology	Effect of temperature on microbial population and performance of an aerobic thermophilic reactor treating cattle slurry and waste food.	Mohaibes M, Vuorinen H, Heinonen-Tanski H.	Environ Technol	10.1080/09593330.2010.533198	2011
Metabolism	Exploring the relationship between gut microbiota and exercise: short-chain fatty acids and their role in metabolism.	Carey RA, Montag D.	BMJ Open Sport Exerc Med	10.1136/bmjsem-2020-000930	2021
	Occurrence of Clostridium spp. in ovine milk and Manchego cheese with late blowing defect: Identification and characterization of isolates	Garde S, Arias Mendoza R, Gaya P, Nunez M.	Int Dairy J	10.1016/j.idairyj.2010.11.003	2011
Genetics	CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids.	Sun X, Zhang H, Jia Y, Li J, Jia M.	Eng Microbiol	10.1016/j.engmic.2024.100154	2024
	Importance of Pre-Milking Udder Hygiene to Reduce Transfer of Clostridial Spores from Teat Skin to Raw Milk.	Burtscher J, Rudavsky T, Zitz U, Neubauer V, Domig KJ.	Microorganisms	10.3390/microorganisms11051337	2023
Phylogeny	Molecular identification of a Bacillus cereus strain from Murrah buffalo milk showed in vitro bioremediation properties on selective heavy metals.	Azad SA, Farjana M, Mazumder B, Abdullah-Al-Mamun M, Haque ABMI.	J Adv Vet Anim Res	10.5455/javar.2020.g394	2020
Transcriptome	Metabolite-Based Mutualistic Interaction between Two Novel Clostridial Species from Pit Mud Enhances Butyrate and Caproate Production.	Sun H, Chai LJ, Fang GY, Lu ZM, Zhang XJ, Wang ST, Shen CH, Shi JS, Xu ZH.	Appl Environ Microbiol	10.1128/aem.00484-22	2022
	Effect of tea polyphenols on the fermentation quality, protein preservation, antioxidant capacity and bacterial community of stylo silage.	Huang Y, Qiu C, Wang Y, Zhang W, He L.	Front Microbiol	10.3389/fmicb.2022.993750	2022
	The Effect of Supplementation Using a Mixture of Fish Oil and Linseed on the Level of Immunomodulatory Components in Bovine Colostrum.	Grodkowska K, Golebiewski M, Slosarz J, Sakowski T, Puppel K.	Molecules	10.3390/molecules28052154	2023
Pathogenicity	Bactericidal effect of bovicin HC5 and nisin against Clostridium tyrobutyricum isolated from spoiled mango pulp.	de Carvalho AA, Mantovani HC, Vanetti MC.	Lett Appl Microbiol	10.1111/j.1472-765x.2007.02150.x	2007
	Cleaner anaerobic fermentation and greenhouse gas reduction of crop straw.	Du Z, Nakagawa A, Fang J, Ridwan R, Astuti WD, Sarwono KA, Sofyan A, Widyastuti Y, Cai Y.	Microbiol Spectr	10.1128/spectrum.00520-24	2024
	Sequence analysis of a bacteriocinogenic plasmid of Clostridium butyricum and expression of the bacteriocin gene in Escherichia coli.	Nakanishi S, Tanaka M.	Anaerobe	10.1016/j.anaerobe.2009.10.002	2010
	Inhibition of Clostridium tyrobutyricum in cheese by Lactobacillus gasseri	Bogovic Matijasic B, Koman Rajsp M, Perko B, Rogelj I.	Int Dairy J	10.1016/j.idairyj.2006.01.011	2007
Metabolism	Preliminary study on the isolation of Clostridium butyricum strains from natural sources in the UK and screening the isolates for presence of the type E botulinal toxin gene.	Ghoddusi HB, Sherburn R.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2010.06.028	2010
	Food Preservatives Induce Proteobacteria Dysbiosis in Human-Microbiota Associated Nod2-Deficient Mice.	Hrncirova L, Machova V, Trckova E, Krejsek J, Hrncir T.	Microorganisms	10.3390/microorganisms7100383	2019
Metabolism	Development of a specific fluorescent phage endolysin for in situ detection of Clostridium species associated with cheese spoilage.	Gomez-Torres N, Dunne M, Garde S, Meijers R, Narbad A, Avila M, Mayer MJ.	Microb Biotechnol	10.1111/1751-7915.12883	2018
	Analysis of lysozyme in cheese by immunocapture mass spectrometry.	Schneider N, Becker CM, Pischetsrieder M.	J Chromatogr B Analyt Technol Biomed Life Sci	10.1016/j.jchromb.2009.07.040	2010
	Functional production of clostridial circularin A in Lactococcus lactis NZ9000 and mutational analysis of its aromatic and cationic residues.	Liu F, van Heel AJ, Chen J, Kuipers OP.	Front Microbiol	10.3389/fmicb.2022.1026290	2022
	Top-down and bottom-up microbiome engineering approaches to enable biomanufacturing from waste biomass.	Lyu X, Nuhu M, Candry P, Wolfanger J, Betenbaugh M, Saldivar A, Zuniga C, Wang Y, Shrestha S.	J Ind Microbiol Biotechnol	10.1093/jimb/kuae025	2024
	Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria.	Ambat A, Antony L, Maji A, Ghimire S, Mattiello S, Kashyap PC, More S, Sebastian V, Scaria J.	Gut Microbes	10.1080/19490976.2024.2382324	2024
	Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications.	Wang X, Liang Z, Wang S, Ma D, Zhu M, Feng J.	Curr Neuropharmacol	10.2174/1570159x19666210629145351	2022
	Continuous Fermentation of Wheat Straw Hydrolysate by Clostridium tyrobutyricum with In-Situ Acids Removal.	Baroi GN, Skiadas IV, Westermann P, Gavala HN.	Waste Biomass Valorization	10.1007/s12649-015-9348-5	2015
Metabolism	Construction and characterization of ack deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid and hydrogen production.	Liu X, Zhu Y, Yang ST.	Biotechnol Prog	10.1021/bp060082g	2006
Stress	Monitoring biochemical changes in bacterial spore during thermal and pressure-assisted thermal processing using FT-IR spectroscopy.	Subramanian A, Ahn J, Balasubramaniam VM, Rodriguez-Saona L.	J Agric Food Chem	10.1021/jf0708241	2007
Genetics	Decarboxylase activity of the non-starter lactic acid bacterium Loigolactobacillus rennini gives crack defects in Gouda cheese through the production of gamma-aminobutyric acid.	Decadt H, Vermote L, Diaz-Munoz C, Weckx S, De Vuyst L.	Appl Environ Microbiol	10.1128/aem.01655-23	2024
Genetics	Metagenomic and Culture-Based Analyses of Microbial Communities from Petroleum Reservoirs with High-Salinity Formation Water, and Their Biotechnological Potential.	Kadnikov VV, Ravin NV, Sokolova DS, Semenova EM, Bidzhieva SK, Beletsky AV, Ershov AP, Babich TL, Khisametdinov MR, Mardanov AV, Nazina TN.	Biology (Basel)	10.3390/biology12101300	2023
Enzymology	Effect of different premilking manual teat-cleaning methods on bacterial spores in milk.	Magnusson M, Christiansson A, Svensson B, Kolstrup C.	J Dairy Sci	10.3168/jds.s0022-0302(06)72429-8	2006
Metabolism	Effect of pH on metabolic pathway shift in fermentation of xylose by Clostridium tyrobutyricum.	Zhu Y, Yang ST.	J Biotechnol	10.1016/j.jbiotec.2004.02.006	2004
	The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice.	Hu X, Guo J, Zhao C, Jiang P, Maimai T, Yanyi L, Cao Y, Fu Y, Zhang N.	ISME J	10.1038/s41396-020-0651-1	2020
	The Improvement of Semen Quality by Dietary Fiber Intake Is Positively Related With Gut Microbiota and SCFA in a Boar Model.	Lin Y, Wang K, Che L, Fang Z, Xu S, Feng B, Zhuo Y, Li J, Wu C, Zhang J, Xiong H, Yu C, Wu.	Front Microbiol	10.3389/fmicb.2022.863315	2022
	Cellulase-lactic acid bacteria synergy action regulates silage fermentation of woody plant.	Du Z, Yamasaki S, Oya T, Cai Y.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02368-2	2023
	Homologous recombination with linear DNA to insert antigenic protein in the flagellin: improvement of the Th1 immune response.	Le Moigne V, Robreau G, Mahana W.	Microbiol Immunol	10.1111/j.1348-0421.2006.tb03768.x	2006
	Cellulase Immobilization on Nanostructured Supports for Biomass Waste Processing.	Sulman AM, Matveeva VG, Bronstein LM.	Nanomaterials (Basel)	10.3390/nano12213796	2022
	The survival of blown pack spoilage associated Clostridium estertheticum and Clostridium gasigenes spores during the ensiling of grass.	Esteves E, Whyte P, Gupta TB, Bolton D.	FEMS Microbes	10.1093/femsmc/xtab013	2021
	Enterococcus spp. as a Producer and Target of Bacteriocins: A Double-Edged Sword in the Antimicrobial Resistance Crisis Context.	Almeida-Santos AC, Novais C, Peixe L, Freitas AR.	Antibiotics (Basel)	10.3390/antibiotics10101215	2021
Pathogenicity	Streptococcus thermophilus 580 produces a bacteriocin potentially suitable for inhibition of Clostridium tyrobutyricum in hard cheese.	Mathot AG, Beliard E, Thuault D.	J Dairy Sci	10.3168/jds.s0022-0302(03)73906-x	2003
Enzymology	Quality of silages from Italian farms as attested by number and identity of microbial indicators.	Rossi F, Dellaglio F.	J Appl Microbiol	10.1111/j.1365-2672.2007.03416.x	2007
Pathogenicity	Extracts containing CLPs of Bacillus amyloliquefaciens JN68 isolated from chicken intestines exert antimicrobial effects, particularly on methicillin-resistant Staphylococcus aureus and Listeria monocytogenes.	Chen JN, Wei CW, Liu HC, Chen SY, Chen C, Juang YM, Lai CC, Yiang GT.	Mol Med Rep	10.3892/mmr.2016.5900	2016
	Evaluating the Quality of Cheese Slices Packaged with Na-Alginate Edible Films Supplemented with Functional Lactic Acid Bacteria Cultures after High-Pressure Processing.	Papadopoulou OS, Argyri AA, Bikouli VC, Lambrinea E, Chorianopoulos N.	Foods	10.3390/foods11182855	2022
Metabolism	Production and Sensing of Butyrate in a Probiotic Escherichia coli Strain.	Bai Y, Mansell TJ.	Int J Mol Sci	10.3390/ijms21103615	2020
	Effects of processing, moisture, and storage length on the fermentation profile, particle size, and ruminal disappearance of reconstituted corn grain.	Gomes ALM, Bueno AVI, Jacovaci FA, Donadel G, Ferraretto LF, Nussio LG, Jobim CC, Daniel JLP.	J Anim Sci	10.1093/jas/skaa332	2020
	Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine.	Yang L, Ding W, Dong Y, Chen C, Zeng Y, Jiang Z, Gan S, You Z, Zhao Y, Zhang Y, Ren X, Wang S, Dai J, Chen Z, Zhu S, Chen L, Shen S, Mao J, Xie Z.	Front Immunol	10.3389/fimmu.2022.955581	2022
Pathogenicity	Treatment with the Probiotic Product Aviguard^® Alleviates Inflammatory Responses during Campylobacter jejuni-Induced Acute Enterocolitis in Mice.	Heimesaat MM, Weschka D, Mousavi S, Bereswill S.	Int J Mol Sci	10.3390/ijms22136683	2021
	Reactor microbiome enriches vegetable oil with n-caproate and n-caprylate for potential functionalized feed additive production via extractive lactate-based chain elongation.	Contreras-Davila CA, Zuidema N, Buisman CJN, Strik DPBTB.	Biotechnol Biofuels	10.1186/s13068-021-02084-9	2021
Genetics	Identification of gut metabolites associated with Parkinson's disease using bioinformatic analyses.	Yan J, Feng X, Zhou X, Zhao M, Xiao H, Li R, Shen H.	Front Aging Neurosci	10.3389/fnagi.2022.927625	2022
Metabolism	Butyrate Treatment of DSS-Induced Ulcerative Colitis Affects the Hepatic Drug Metabolism in Mice.	Jourova L, Satka S, Frybortova V, Zapletalova I, Anzenbacher P, Anzenbacherova E, Hermanova PP, Drabonova B, Srutkova D, Kozakova H, Hudcovic T.	Front Pharmacol	10.3389/fphar.2022.936013	2022
Phylogeny	Characterization of Clostridium spp. isolated from spoiled processed cheese products.	Lycken L, Borch E.	J Food Prot	10.4315/0362-028x-69.8.1887	2006
	Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage.	Zhou B, Zhen X, Zhou H, Zhao F, Fan C, Perculija V, Tong Y, Mi Z, Ouyang S.	PLoS Pathog	10.1371/journal.ppat.1008394	2020
	Using PacBio SMRT Sequencing Technology and Metabolomics to Explore the Microbiota-Metabolome Interaction Related to Silage Fermentation of Woody Plant.	Du Z, Sun L, Lin Y, Yang F, Cai Y.	Front Microbiol	10.3389/fmicb.2022.857431	2022
Metabolism	Extractive fermentation for butyric acid production from glucose by Clostridium tyrobutyricum.	Wu Z, Yang ST.	Biotechnol Bioeng	10.1002/bit.10542	2003
Metabolism	Insight into the Lytic Functions of the Lactococcal Prophage TP712.	Escobedo S, Campelo AB, Wegmann U, Garcia P, Rodriguez A, Martinez B.	Viruses	10.3390/v11100881	2019
Metabolism	Phage lysin that specifically eliminates Clostridium botulinum Group I cells.	Zhang Z, Lahti M, Douillard FP, Korkeala H, Lindstrom M.	Sci Rep	10.1038/s41598-020-78622-6	2020
	Efficient lactic acid production from dilute acid-pretreated lignocellulosic biomass by a synthetic consortium of engineered Pseudomonas putida and Bacillus coagulans.	Zou L, Ouyang S, Hu Y, Zheng Z, Ouyang J.	Biotechnol Biofuels	10.1186/s13068-021-02078-7	2021
Metabolism	Acetate promotes microbial reductive debromination of tetrabromobisphenol A during the startup phase of anaerobic wastewater sludge bioreactors.	Lefevre E, Redfern L, Cooper EM, Stapleton HM, Gunsch CK.	Sci Total Environ	10.1016/j.scitotenv.2018.11.403	2019
Pathogenicity	Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood-brain barrier.	Wang Y, Chen R, Shi G, Huang X, Li K, Wang R, Cao X, Yang Z, Zhao N, Yan J.	Neural Regen Res	10.4103/nrr.nrr-d-23-01511	2026
Metabolism	Adaptation of Clostridium tyrobutyricum for enhanced tolerance to butyric acid in a fibrous-bed bioreactor.	Zhu Y, Yang ST.	Biotechnol Prog	10.1021/bp025647x	2003
	beta-Lytic Protease of Lysobacter capsici VKM B-2533^T.	Afoshin AS, Konstantinov MA, Toropygin IY, Kudryakova IV, Vasilyeva NV.	Antibiotics (Basel)	10.3390/antibiotics9110744	2020
Genetics	Dissecting the Arginine and Lysine Biosynthetic Pathways and Their Relationship in Haloarchaeon Natrinema gari J7-2 via Endogenous CRISPR-Cas System-Based Genome Editing.	Wu Y, Zhang J, Wang B, Zhang Y, Li H, Liu Y, Yin J, He D, Luo H, Gan F, Tang B, Tang XF.	Microbiol Spectr	10.1128/spectrum.00288-23	2023
	Developing a genetic engineering method for Acetobacterium wieringae to expand one-carbon valorization pathways.	Moreira JPC, Heap JT, Alves JI, Domingues L.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02259-6	2023
	Structural Transformation and Creativity Induced by Biological Agents during Fermentation of Edible Nuts from Terminalia catappa.	Odutayo OE, Adegboye BE, Omonigbehin EA, Olawole TD, Ogunlana OO, Afolabi IS.	Molecules	10.3390/molecules26195874	2021
Pathogenicity	Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572.	Diez-Echave P, Martin-Cabrejas I, Garrido-Mesa J, Langa S, Vezza T, Landete JM, Hidalgo-Garcia L, Algieri F, Mayer MJ, Narbad A, Garcia-Lafuente A, Medina M, Rodriguez-Nogales A, Rodriguez-Cabezas ME, Galvez J, Arques JL.	Nutrients	10.3390/nu13061860	2021
Genetics	Comparative genomics of the proteostasis network in extreme acidophiles.	Izquierdo-Fiallo K, Munoz-Villagran C, Orellana O, Sjoberg R, Levican G.	PLoS One	10.1371/journal.pone.0291164	2023
Metabolism	Characterization of a 3944 Da bacteriocin, produced by Enterococcus mundtii ST15, with activity against Gram-positive and Gram-negative bacteria.	De Kwaadsteniet M, Todorov SD, Knoetze H, Dicks LM.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2005.03.021	2005
	Dynamics of dark fermentation microbial communities in the light of lactate and butyrate production.	Detman A, Laubitz D, Chojnacka A, Kiela PR, Salamon A, Barberan A, Chen Y, Yang F, Blaszczyk MK, Sikora A.	Microbiome	10.1186/s40168-021-01105-x	2021
	LAMP-Based Point-of-Care Biosensors for Rapid Pathogen Detection.	Das D, Lin CW, Chuang HS.	Biosensors (Basel)	10.3390/bios12121068	2022
	Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood-Air Barrier Hyperpermeability.	Wang T, Liu C, Pan LH, Liu Z, Li CL, Lin JY, He Y, Xiao JY, Wu S, Qin Y, Li Z, Lin F.	Front Pharmacol	10.3389/fphar.2020.569251	2020
	Potential risks when spreading anaerobic digestion residues on grass silage crops survival of bacteria, moulds and viruses	Johansson M, Emmoth E, Salomonsson AC, Albihn A.	Grass and forage science.	10.1111/j.1365-2494.2005.00466.x	2005
Genetics	Alleviation of Metabolic Disturbance by Substituting Kanjang High in Bacillus for Salt through Modulation of Gut Microbiota in Estrogen-Deficient Rats.	Park S, Zhang T, Yue Y, Jeong SJ, Ryu MS, Wu X, Yang HJ, Jeong DY.	Foods	10.3390/foods11131951	2022
	Little Impact of NaCl Reduction in Swiss-Type Cheese.	Gagnaire V, Lecomte X, Richoux R, Genay M, Jardin J, Briard-Bion V, Kerjean JR, Thierry A.	Front Nutr	10.3389/fnut.2022.888179	2022
	Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.	Rack JGM, Zorzini V, Zhu Z, Schuller M, Ahel D, Ahel I.	Open Biol	10.1098/rsob.200237	2020
	Heat-induced modifications in casein dispersions affecting their rennetability	Schreiber R.	Int Dairy J	10.1016/s0958-6946(01)00083-8	2001
Phylogeny	Bacterial Populations in International Artisanal Kefirs.	Sindi A, Badsha MB, Unlu G.	Microorganisms	10.3390/microorganisms8091318	2020
Metabolism	A mutation of Aspergillus niger for hyper-production of citric acid from corn meal hydrolysate in a bioreactor.	Hu W, Liu J, Chen JH, Wang SY, Lu D, Wu QH, Li WJ.	J Zhejiang Univ Sci B	10.1631/jzus.b1400132	2014
Enzymology	Reporter Phage-Based Detection of Bacterial Pathogens: Design Guidelines and Recent Developments.	Meile S, Kilcher S, Loessner MJ, Dunne M.	Viruses	10.3390/v12090944	2020
	Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats.	Lv WJ, Liu C, Yu LZ, Zhou JH, Li Y, Xiong Y, Guo A, Chao LM, Qu Q, Wei GW, Tang XG, Yin YL, Guo SN.	Oxid Med Cell Longev	10.1155/2020/1241894	2020
	Cheeses Made from Raw and Pasteurized Cow's Milk Analysed by an Electronic Nose and an Electronic Tongue.	Valente NIP, Rudnitskaya A, Oliveira JABP, Gomes MTSR, Gaspar EMM.	Sensors (Basel)	10.3390/s18082415	2018
Metabolism	Genomic sequence and characterization of the virulent bacteriophage phiCTP1 from Clostridium tyrobutyricum and heterologous expression of its endolysin.	Mayer MJ, Payne J, Gasson MJ, Narbad A.	Appl Environ Microbiol	10.1128/aem.00989-10	2010
	Gouda cheese spoilage prevention: Biodegradable coating induced by Bunium persicum essential oil and lactoperoxidase system.	Saravani M, Ehsani A, Aliakbarlu J, Ghasempour Z.	Food Sci Nutr	10.1002/fsn3.888	2019
Phylogeny	Identification of Clostridium spp. derived from a sheep and cattle slaughterhouse by matrix-assisted laser desorption and ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S rDNA sequencing.	Bakhtiary F, Sayevand HR, Remely M, Hippe B, Indra A, Hosseini H, Haslberger AG.	J Food Sci Technol	10.1007/s13197-018-3255-2	2018
Metabolism	LPS Inhibits Fatty Acid Absorption in Enterocytes through TNF-alpha Secreted by Macrophages.	Liu H, Kai L, Du H, Wang X, Wang Y.	Cells	10.3390/cells8121626	2019
	High-throughput qPCR and 16S rRNA gene amplicon sequencing as complementary methods for the investigation of the cheese microbiota.	Dreier M, Meola M, Berthoud H, Shani N, Wechsler D, Junier P.	BMC Microbiol	10.1186/s12866-022-02451-y	2022
	A paradigm shift towards production of sustainable bioenergy and advanced products from Cannabis/hemp biomass in Canada.	Brar KK, Raheja Y, Chadha BS, Magdouli S, Brar SK, Yang YH, Bhatia SK, Koubaa A.	Biomass Convers Biorefin	10.1007/s13399-022-02570-6	2022
	Effect of pasteurization and seasonal variations in the microflora of ewe's milk for cheesemaking	Salmeron J, Vega Cd, Perez-Elortondo FJ, Albisu M, Barron LJR.	Food Microbiol	10.1006/fmic.2001.0475	2002
Phylogeny	Bacterial community in naturally fermented milk products of Arunachal Pradesh and Sikkim of India analysed by high-throughput amplicon sequencing.	Shangpliang HNJ, Rai R, Keisam S, Jeyaram K, Tamang JP.	Sci Rep	10.1038/s41598-018-19524-6	2018
	The stereoselectivity of the use of lactic acid by Clostridium tyrobutyricum	Huchet V, Thuault D, Bourgeois CM.	Food Microbiol	10.1006/fmic.1996.0072	1997
	Metabolic modeling of bacterial co-culture systems predicts enhanced carbon monoxide-to-butyrate conversion compared to monoculture systems.	Li X, Henson MA.	Biochem Eng J	10.1016/j.bej.2019.107338	2019
	Ropiness in Bread-A Re-Emerging Spoilage Phenomenon.	Pacher N, Burtscher J, Johler S, Etter D, Bender D, Fieseler L, Domig KJ.	Foods	10.3390/foods11193021	2022
Enzymology	Enoate reductases of Clostridia. Cloning, sequencing, and expression.	Rohdich F, Wiese A, Feicht R, Simon H, Bacher A.	J Biol Chem	10.1074/jbc.m008656200	2001
Pathogenicity	Microbial Immuno-Communication in Neurodegenerative Diseases.	Main BS, Minter MR.	Front Neurosci	10.3389/fnins.2017.00151	2017
	Partial analysis of the flagellar antigenic determinant recognized by a monoclonal antibody to Clostridium tyrobutyricum.	Bedouet L, Arnold F, Robreau G, Batina P, Talbot F, Malcoste R.	Microbiol Immunol	10.1111/j.1348-0421.1998.tb02256.x	1998
	The gut microbiota and developmental programming of the testis in mice.	Al-Asmakh M, Stukenborg JB, Reda A, Anuar F, Strand ML, Hedin L, Pettersson S, Soder O.	PLoS One	10.1371/journal.pone.0103809	2014
	Microbiome, Immunomodulation, and the Neuronal System.	Marietta E, Horwath I, Taneja V.	Neurotherapeutics	10.1007/s13311-017-0601-4	2018
Phylogeny	Nanopore Long-Read Guided Complete Genome Assembly of Hydrogenophaga intermedia, and Genomic Insights into 4-Aminobenzenesulfonate, p-Aminobenzoic Acid and Hydrogen Metabolism in the Genus Hydrogenophaga.	Gan HM, Lee YP, Austin CM.	Front Microbiol	10.3389/fmicb.2017.01880	2017
Enzymology	Unraveling the Genotypic and Phenotypic Diversity of the Psychrophilic Clostridium estertheticum Complex, a Meat Spoilage Agent.	Wambui J, Stevens MJA, Cernela N, Stephan R.	Front Microbiol	10.3389/fmicb.2022.856810	2022
	Hydrogen as a Co-electron Donor for Chain Elongation With Complex Communities.	Baleeiro FCF, Kleinsteuber S, Strauber H.	Front Bioeng Biotechnol	10.3389/fbioe.2021.650631	2021
Transcriptome	Increased Butyrate Production in Clostridium saccharoperbutylacetonicum from Lignocellulose-Derived Sugars.	Baur ST, Markussen S, Di Bartolomeo F, Poehlein A, Baker A, Jenkinson ER, Daniel R, Wentzel A, Durre P.	Appl Environ Microbiol	10.1128/aem.02419-21	2022
	Effective use of nisin to control Bacillus and Clostridium spoilage of a pasteurized mashed potato product.	Thomas LV, Ingram RE, Bevis HE, Davies EA, Milne CF, Delves-Broughton J.	J Food Prot	10.4315/0362-028x-65.10.1580	2002
Metabolism	Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.	Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J.	Front Immunol	10.3389/fimmu.2021.715098	2021
	One-pot production of butyl butyrate from glucose using a cognate "diamond-shaped" E. coli consortium.	Sinumvayo JP, Zhao C, Liu G, Li Y, Zhang Y.	Bioresour Bioprocess	10.1186/s40643-021-00372-8	2021
Metabolism	Novel Lytic Enzyme of Prophage Origin from Clostridium botulinum E3 Strain Alaska E43 with Bactericidal Activity against Clostridial Cells.	Morzywolek A, Plotka M, Kaczorowska AK, Szadkowska M, Kozlowski LP, Wyrzykowski D, Makowska J, Waters JJ, Swift SM, Donovan DM, Kaczorowski T.	Int J Mol Sci	10.3390/ijms22179536	2021
Metabolism	The impact of the quality of silage on animal health and food safety: a review.	Driehuis F, Oude Elferink SJ.	Vet Q	10.1080/01652176.2000.9695061	2000
Pathogenicity	Proteomic Adaptation of Clostridioides difficile to Treatment with the Antimicrobial Peptide Nisin.	Maass S, Bartel J, Mucke PA, Schluter R, Sura T, Zaschke-Kriesche J, Smits SHJ, Becher D.	Cells	10.3390/cells10020372	2021
	Oxygen radical based on non-thermal atmospheric pressure plasma alleviates lignin-derived phenolic toxicity in yeast.	Ito S, Sakai K, Gamaleev V, Ito M, Hori M, Kato M, Shimizu M.	Biotechnol Biofuels	10.1186/s13068-020-1655-9	2020
	Production, Characterization, and Antimicrobial Activity of Mycocin Produced by Debaryomyces hansenii DSMZ70238.	Al-Qaysi SAS, Al-Haideri H, Thabit ZA, Al-Kubaisy WHAA, Ibrahim JAA.	Int J Microbiol	10.1155/2017/2605382	2017
Enzymology	Quantitative detection of Clostridium tyrobutyricum in milk by real-time PCR.	Lopez-Enriquez L, Rodriguez-Lazaro D, Hernandez M.	Appl Environ Microbiol	10.1128/aem.02642-06	2007
	The Use of Bacteriophages in Biotechnology and Recent Insights into Proteomics.	Abril AG, Carrera M, Notario V, Sanchez-Perez A, Villa TG.	Antibiotics (Basel)	10.3390/antibiotics11050653	2022
	Altered Gut Microbiome in Parkinson's Disease and the Influence of Lipopolysaccharide in a Human alpha-Synuclein Over-Expressing Mouse Model.	Gorecki AM, Preskey L, Bakeberg MC, Kenna JE, Gildenhuys C, MacDougall G, Dunlop SA, Mastaglia FL, Akkari PA, Koengten F, Anderton RS.	Front Neurosci	10.3389/fnins.2019.00839	2019
Enzymology	Optimization of alkaline protease production by rational deletion of sporulation related genes in Bacillus licheniformis.	Zhou C, Zhou H, Zhang H, Lu F.	Microb Cell Fact	10.1186/s12934-019-1174-1	2019
Metabolism	A Multibacteriocin Cheese Starter System, Comprising Nisin and Lacticin 3147 in Lactococcus lactis, in Combination with Plantaricin from Lactobacillus plantarum.	Mills S, Griffin C, O'Connor PM, Serrano LM, Meijer WC, Hill C, Ross RP.	Appl Environ Microbiol	10.1128/aem.00799-17	2017
Metabolism	Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets.	Nguyen TD, Hallenius FF, Lin X, Nyman M, Prykhodko O.	Nutrients	10.3390/nu12041202	2020
	A sensitive HPLC method to detect hen's egg white lysozyme in milk and dairy products	Pellegrino L, Tirelli A.	Int Dairy J	10.1016/s0958-6946(00)00065-0	2000
	The gut microbiome and Alzheimer's disease: Complex and bidirectional interactions.	Tarawneh R, Penhos E.	Neurosci Biobehav Rev	10.1016/j.neubiorev.2022.104814	2022
Enzymology	Purification and characterization of the NADH-dependent (S)-specific 3-oxobutyryl-CoA reductase from Clostridium tyrobutyricum.	Bayer M, Gunther H, Simon H.	Arch Microbiol	10.1007/bf00393386	1995
Enzymology	Biochemical properties of Streptococcus macedonicus strains isolated from Greek Kasseri cheese.	Georgalaki MD, Sarantinopoulos P, Ferreira ES, De Vuyst L, Kalantzopoulos G, Tsakalidou E.	J Appl Microbiol	10.1046/j.1365-2672.2000.01055.x	2000
	Brining time effect on physicochemical and microbiological parameters in Idiazábal cheese.	Perez Elortondo FJ, Albisu M, Barcina Y.	Int J Food Microbiol	10.1016/s0168-1605(99)00068-9	1999
	Assessment of sensory properties of cheese by near-infrared spectroscopy	Sorensen LK, Jepsen R.	Int Dairy J	10.1016/s0958-6946(98)00130-7	1998
	An Overview of Antimicrobial Activity of Lysozyme and Its Functionality in Cheese.	Khorshidian N, Khanniri E, Koushki MR, Sohrabvandi S, Yousefi M.	Front Nutr	10.3389/fnut.2022.833618	2022
Enzymology	Purification and characterization of an (S)-3-hydroxycarboxylate oxidoreductase from Clostridium tyrobutyricum.	Bayer M, Gunther H, Simon H.	Appl Microbiol Biotechnol	10.1007/bf00170222	1994
	Crystal Structure of the CTP1L Endolysin Reveals How Its Activity Is Regulated by a Secondary Translation Product.	Dunne M, Leicht S, Krichel B, Mertens HD, Thompson A, Krijgsveld J, Svergun DI, Gomez-Torres N, Garde S, Uetrecht C, Narbad A, Mayer MJ, Meijers R.	J Biol Chem	10.1074/jbc.m115.671172	2016
	Influence of farmyard manure on the quality of grass silage	Rammer C, Lingvall P.	J Sci Food Agric	10.1002/(sici)1097-0010(199709)75:1<133::aid-jsfa856>3.0.co;2-2	1997
	Reprogramming microbial populations using a programmed lysis system to improve chemical production.	Diao W, Guo L, Ding Q, Gao C, Hu G, Chen X, Li Y, Zhang L, Chen W, Chen J, Liu L.	Nat Commun	10.1038/s41467-021-27226-3	2021
	Ensiling of manured crops--does repeated spreading of slurry increase the hygienic risk?	Rammer C, Lingvall P, Salomon E.	J Sci Food Agric	10.1002/(sici)1097-0010(199703)73:3<329::aid-jsfa734>3.0.co;2-q	1997
	Anodic electro-fermentation of 3-hydroxypropionic acid from glycerol by recombinant Klebsiella pneumoniae L17 in a bioelectrochemical system.	Kim C, Kim MY, Michie I, Jeon BH, Premier GC, Park S, Kim JR.	Biotechnol Biofuels	10.1186/s13068-017-0886-x	2017
	Production of the biocommodities butanol and acetone from methanol with fluorescent FAST-tagged proteins using metabolically engineered strains of Eubacterium limosum.	Flaiz M, Ludwig G, Bengelsdorf FR, Durre P.	Biotechnol Biofuels	10.1186/s13068-021-01966-2	2021
Metabolism	Inhibition of Clostridium tyrobutyricum by bacteriocin-like substances produced by lactic acid bacteria.	Thuault D, Beliard E, Le Guern J, Bourgeois CM.	J Dairy Sci	10.3168/jds.s0022-0302(91)78266-0	1991
Enzymology	Genomic sequence of bacteriophage ATCC 8074-B1 and activity of its endolysin and engineered variants against Clostridium sporogenes.	Mayer MJ, Gasson MJ, Narbad A.	Appl Environ Microbiol	10.1128/aem.07884-11	2012
	Growth of Clostridium tyrobutyricum during fermentation and aerobic deterioration of grass silage	Jonsson A.	J Sci Food Agric	10.1002/jsfa.2740540407	1991
	Efficacy and safety assessment of two enterococci phages in an in vitro biofilm wound model.	Melo LDR, Ferreira R, Costa AR, Oliveira H, Azeredo J.	Sci Rep	10.1038/s41598-019-43115-8	2019
	Selection in chemostat culture of a mutant strain of Clostridium tyrobutyricum improved in its reduction of ketones.	Tidswell EC, Thompson AN, Gareth Morris J.	Appl Microbiol Biotechnol	10.1007/bf00172719	1991
Metabolism	Biohydrogen production beyond the Thauer limit by precision design of artificial microbial consortia.	Ergal I, Graf O, Hasibar B, Steiner M, Vukotic S, Bochmann G, Fuchs W, Rittmann SKR.	Commun Biol	10.1038/s42003-020-01159-x	2020
	Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota.	Li H, Zhang L, Li J, Wu Q, Qian L, He J, Ni Y, Kovatcheva-Datchary P, Yuan R, Liu S, Shen L, Zhang M, Sheng B, Li P, Kang K, Wu L, Fang Q, Long X, Wang X, Li Y, Ye Y, Ye J, Bao Y, Zhao Y, Xu G, Liu X, Panagiotou G, Xu A, Jia W.	Nat Metab	10.1038/s42255-024-00988-y	2024
	Probiotic Properties of Enterococcus Isolated From Artisanal Dairy Products.	Nami Y, Vaseghi Bakhshayesh R, Mohammadzadeh Jalaly H, Lotfi H, Lotfi H, Eslami S, Hejazi MA.	Front Microbiol	10.3389/fmicb.2019.00300	2019
	Growth Limiting pH, Water Activity, and Temperature for Neurotoxigenic Strains of Clostridium butyricum.	Ghoddusi HB, Sherburn RE, Aboaba OO.	ISRN Microbiol	10.1155/2013/731430	2013
Metabolism	Regulation of common neurological disorders by gut microbial metabolites.	Park J, Kim CH.	Exp Mol Med	10.1038/s12276-021-00703-x	2021
Enzymology	EPR and Mössbauer spectroscopic studies on enoate reductase.	Caldeira J, Feicht R, White H, Teixeira M, Moura JJ, Simon H, Moura I.	J Biol Chem	10.1074/jbc.271.31.18743	1996
	Anaerobic Process for Bioenergy Recovery From Dairy Waste: Meta-Analysis and Enumeration of Microbial Community Related to Intermediates Production.	Pagliano G, Ventorino V, Panico A, Romano I, Pirozzi F, Pepe O.	Front Microbiol	10.3389/fmicb.2018.03229	2018
	[Efficiency of microbank systems for the conservation of microorganisms relevant to veterinary medicine and others which are not easy to cultivate].	Seidel KE, Gareis M.	Berl Munch Tierarztl Wochenschr		1995
Biotechnology	Enumeration and confirmation of Clostridium tyrobutyricum in silages using neutral red, D-cycloserine, and lactate dehydrogenase activity.	Jonsson A.	J Dairy Sci	10.3168/jds.s0022-0302(90)78725-5	1990
Enzymology	Iron removal from milk and other nutrient media with a chelating resin.	Feng M, van der Does L, Bantjes A, de Groote JM.	J Dairy Sci	10.3168/jds.s0022-0302(95)76615-2	1995
	Demonstration of a surface antigen of Clostridium tyrobutyricum by use of immunoblotting with a monoclonal antibody.	Gueguen F, Robreau G, Talbot F, Malcoste R.	Microbiol Immunol	10.1111/j.1348-0421.1990.tb00991.x	1990
Pathogenicity	Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system.	Lee HU, McPherson ZE, Tan B, Korecka A, Pettersson S.	J Mol Med (Berl)	10.1007/s00109-016-1486-0	2017
	Production of bacteriocins active against Listeria monocytogenes and Listeria innocua from dairy enterococci	Tarelli GT, Carminati D, Giraffa G.	Food Microbiol	10.1006/fmic.1994.1027	1994
Genetics	Challenges and Advances in Genome Editing Technologies in Streptomyces.	Zhao Y, Li G, Chen Y, Lu Y.	Biomolecules	10.3390/biom10050734	2020
	Antimicrobial compounds from Lactobacillus casei and Lactobacillus helveticus.	Vescovo M, Scolari GL, Caravaggi L, Bottazzi V.	New Microbiol		1993
	Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid.	Joo JC, Khusnutdinova AN, Flick R, Kim T, Bornscheuer UT, Yakunin AF, Mahadevan R.	Chem Sci	10.1039/c6sc02842j	2017
Genetics	Complete genome sequence of Leuconostoc gelidum subsp. gasicomitatum KG16-1, isolated from vacuum-packaged vegetable sausages.	Andreevskaya M, Hultman J, Johansson P, Laine P, Paulin L, Auvinen P, Bjorkroth J.	Stand Genomic Sci	10.1186/s40793-016-0164-8	2016
	Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains.	Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A, Bullough PA.	Food Microbiol	10.1016/j.fm.2016.06.003	2016
	Advances in the development and application of microbial consortia for metabolic engineering.	Jawed K, Yazdani SS, Koffas MA.	Metab Eng Commun	10.1016/j.mec.2019.e00095	2019
Metabolism	Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.	Kang DJ, Ridlon JM, Moore DR, Barnes S, Hylemon PB.	Biochim Biophys Acta	10.1016/j.bbalip.2007.10.008	2008
Biotechnology	Detection of propionic acid bacteria in cheese.	Drinan FD, Cogan TM.	J Dairy Res	10.1017/s0022029900030259	1992
Enzymology	LysPBC2, a Novel Endolysin Harboring a Bacillus cereus Spore Binding Domain.	Kong M, Na H, Ha NC, Ryu S.	Appl Environ Microbiol	10.1128/aem.02462-18	2019
	Bacteriocins From LAB and Other Alternative Approaches for the Control of Clostridium and Clostridiodes Related Gastrointestinal Colitis.	Todorov SD, Kang HJ, Ivanova IV, Holzapfel WH.	Front Bioeng Biotechnol	10.3389/fbioe.2020.581778	2020
	Major protein components in the cell envelope of Clostridium tyrobutyricum.	Bergere JL, Hayes H, Commissaire J.	Ann Inst Pasteur Microbiol	10.1016/s0769-2609(86)80117-x	1986
	[Demonstration of 2 main serological groups in Clostridium tyrobutyricum].	Bergere JL.	Ann Inst Pasteur Microbiol (1985)	10.1016/s0769-2609(85)80008-9	1985
	Advantages and limitations of experimental autoimmune encephalomyelitis in breaking down the role of the gut microbiome in multiple sclerosis.	Melamed E, Palmer JL, Fonken C.	Front Mol Neurosci	10.3389/fnmol.2022.1019877	2022
Stress	A high-molecular-mass cell wall protein released from Clostridium tyrobutyricum by heat treatment.	Hayes H, Commissaire J, Bergere JL.	FEBS Lett	10.1016/0014-5793(84)81174-6	1984
	The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental Factors and Gene Interactions via Mobile Genetic Elements.	Smith TJ, Williamson CHD, Hill KK, Johnson SL, Xie G, Anniballi F, Auricchio B, Fernandez RA, Caballero PA, Keim P, Sahl JW.	Front Microbiol	10.3389/fmicb.2021.566908	2021
	Microbiota Assessments for the Identification and Confirmation of Slit Defect-Causing Bacteria in Milk and Cheddar Cheese.	Xue Z, Brooks JT, Quart Z, Stevens ET, Kable ME, Heidenreich J, McLeod J, Marco ML.	mSystems	10.1128/msystems.01114-20	2021
	Influence of Lysozyme on Selected Bacteria Associated with Gouda Cheese.	Bester BH, Lombard SH.	J Food Prot	10.4315/0362-028x-53.4.306	1990
	Volatile Fatty Acids as Carbon Sources for Polyhydroxyalkanoates Production.	Szacherska K, Oleskowicz-Popiel P, Ciesielski S, Mozejko-Ciesielska J.	Polymers (Basel)	10.3390/polym13030321	2021
	Dynamics and Complexity of Dark Fermentation Microbial Communities Producing Hydrogen From Sugar Beet Molasses in Continuously Operating Packed Bed Reactors.	Detman A, Laubitz D, Chojnacka A, Wiktorowska-Sowa E, Piotrowski J, Salamon A, Kazmierczak W, Blaszczyk MK, Barberan A, Chen Y, Lupikasza E, Yang F, Sikora A.	Front Microbiol	10.3389/fmicb.2020.612344	2020
	Revealing the Characteristics of Glucose- and Lactate-Based Chain Elongation for Caproate Production by Caproicibacterium lactatifermentans through Transcriptomic, Bioenergetic, and Regulatory Analyses.	Wang H, Zhou W, Gao J, Ren C, Xu Y.	mSystems	10.1128/msystems.00534-22	2022
Biotechnology	Antagonistic activity of Debaryomyces hansenii towards Clostridium tyrobutyricum and Cl. butyricum.	Fatichenti F, Bergere JL, Deiana P, Farris GA.	J Dairy Res	10.1017/s0022029900032684	1983
Genetics	Cas9 Nickase-Assisted RNA Repression Enables Stable and Efficient Manipulation of Essential Metabolic Genes in Clostridium cellulolyticum.	Xu T, Li Y, He Z, Van Nostrand JD, Zhou J.	Front Microbiol	10.3389/fmicb.2017.01744	2017
Metabolism	Improved n-Butanol Production from Clostridium cellulovorans by Integrated Metabolic and Evolutionary Engineering.	Wen Z, Ledesma-Amaro R, Lin J, Jiang Y, Yang S.	Appl Environ Microbiol	10.1128/aem.02560-18	2019
Enzymology	Structure of enoate reductase from a Clostridium tyrobutyricum (C. spec. La1).	Kuno S, Bacher A, Simon H.	Biol Chem Hoppe Seyler	10.1515/bchm3.1985.366.1.463	1985
	Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof.	Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E.	Sci Rep	10.1038/s41598-018-27225-3	2018
Enzymology	Design and applications of sensitive enzyme immunoassays specific for clostridial enoate reductases.	Krause G, Simon H.	Z Naturforsch C J Biosci	10.1515/znc-1989-5-602	1989
Enzymology	A direct PCR detection method for Clostridium tyrobutyricum spores in up to 100 milliliters of raw milk.	Herman LM, De Block JH, Waes GM.	Appl Environ Microbiol	10.1128/aem.61.12.4141-4146.1995	1995
Pathogenicity	Improving isopropanol tolerance and production of Clostridium beijerinckii DSM 6423 by random mutagenesis and genome shuffling.	Gerando HM, Fayolle-Guichard F, Rudant L, Millah SK, Monot F, Lopes Ferreira N, Lopez-Contreras AM.	Appl Microbiol Biotechnol	10.1007/s00253-016-7302-5	2016
	Reduction of Nitrite in Meat Products through the Application of Various Plant-Based Ingredients.	Ferysiuk K, Wojciak KM.	Antioxidants (Basel)	10.3390/antiox9080711	2020
Enzymology	Reductions of 2-enals, dehydrogenation of saturated aldehydes and their racemisation.	Thanos I, Deffner A, Simon H.	Biol Chem Hoppe Seyler	10.1515/bchm3.1988.369.1.451	1988
	Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats.	Malago JJ, Sangu CL.	J Zhejiang Univ Sci B	10.1631/jzus.b1400191	2015
Enzymology	Recombinant expression and characterisation of the oxygen-sensitive 2-enoate reductase from Clostridium sporogenes.	Mordaka PM, Hall SJ, Minton N, Stephens G.	Microbiology (Reading)	10.1099/mic.0.000568	2018
Enzymology	Menadione reductase from Clostridium tyrobutyricum.	Petitdemange H, Marczak R, Raval G, Gay R.	Can J Microbiol	10.1139/m80-053	1980
	n-Butanol derived from biochemical and chemical routes: A review.	Ndaba B, Chiyanzu I, Marx S.	Biotechnol Rep (Amst)	10.1016/j.btre.2015.08.001	2015
Phylogeny	[Taxonomic characters of "Clostridium tyrobutyricum" (author's transl)].	Roux C, Bergere JL.	Ann Microbiol (Paris)		1977
	Selection and characterization of DNA aptamers for egg white lysozyme.	Tran DT, Janssen KP, Pollet J, Lammertyn E, Anne J, Van Schepdael A, Lammertyn J.	Molecules	10.3390/molecules15031127	2010
Metabolism	Chiral products from non-pyridine nucleotide-dependent reductases and methods for NAD(P)H regeneration.	Simon H, Gunther H, Bader J, Neumann S.	Ciba Found Symp	10.1002/9780470720929.ch8	1985
	The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders.	Ganci M, Suleyman E, Butt H, Ball M.	Brain Behav	10.1002/brb3.1408	2019
Metabolism	Unravelling the Reduction Pathway as an Alternative Metabolic Route to Hydroxycinnamate Decarboxylation in Lactobacillus plantarum.	Santamaria L, Reveron I, Lopez de Felipe F, de Las Rivas B, Munoz R.	Appl Environ Microbiol	10.1128/aem.01123-18	2018
Enzymology	Isolation and identification of anaerobic contaminants from a machine for producing processed cheese.	Savoy de Giori G, Font de Valdez G, Pesce de Ruiz Holgado A, Oliver G.	Rev Argent Microbiol		1982
Metabolism	Adaptation and transcriptome analysis of Aureobasidium pullulans in corncob hydrolysate for increased inhibitor tolerance to malic acid production.	Zou X, Wang Y, Tu G, Zan Z, Wu X.	PLoS One	10.1371/journal.pone.0121416	2015
Metabolism	Flagellin glycosylation in Paenibacillus alvei CCM 2051T.	Janesch B, Schirmeister F, Maresch D, Altmann F, Messner P, Kolarich D, Schaffer C.	Glycobiology	10.1093/glycob/cwv087	2016
	Characterization of hemicellulase and cellulase from the extremely thermophilic bacterium Caldicellulosiruptor owensensis and their potential application for bioconversion of lignocellulosic biomass without pretreatment.	Peng X, Qiao W, Mi S, Jia X, Su H, Han Y.	Biotechnol Biofuels	10.1186/s13068-015-0313-0	2015
Phylogeny	The Core and Seasonal Microbiota of Raw Bovine Milk in Tanker Trucks and the Impact of Transfer to a Milk Processing Facility.	Kable ME, Srisengfa Y, Laird M, Zaragoza J, McLeod J, Heidenreich J, Marco ML.	mBio	10.1128/mbio.00836-16	2016
Metabolism	Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z.	Piper C, Hill C, Cotter PD, Ross RP.	Microb Biotechnol	10.1111/j.1751-7915.2010.00207.x	2011
Metabolism	Macedocin, a food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198.	Georgalaki MD, Van Den Berghe E, Kritikos D, Devreese B, Van Beeumen J, Kalantzopoulos G, De Vuyst L, Tsakalidou E.	Appl Environ Microbiol	10.1128/aem.68.12.5891-5903.2002	2002
Metabolism	Engineered Production of Short Chain Fatty Acid in Escherichia coli Using Fatty Acid Synthesis Pathway.	Jawed K, Mattam AJ, Fatma Z, Wajid S, Abdin MZ, Yazdani SS.	PLoS One	10.1371/journal.pone.0160035	2016
	[The spore germination of "Clostridium tyrobutyricum" III.--An hypothesis on the mechanism of initiation (author's transl)].	Bergere JL, Zevaco C, Cherrier C, Petitdemange H.	Ann Microbiol (Paris)		1975
	Escherichia coli ATCC 8739 Adapts to the Presence of Sodium Chloride, Monosodium Glutamate, and Benzoic Acid after Extended Culture.	Lee CH, Oon JS, Lee KC, Ling MH.	ISRN Microbiol	10.5402/2012/965356	2012
	Advanced Electroanalysis for Electrosynthesis.	Brachi M, El Housseini W, Beaver K, Jadhav R, Dantanarayana A, Boucher DG, Minteer SD.	ACS Org Inorg Au	10.1021/acsorginorgau.3c00051	2024
	Antimicrobial Activity of Copper Alone and in Combination with Lactic Acid against Escherichia coli O157:H7 in Laboratory Medium and on the Surface of Lettuce and Tomatoes.	Gyawali R, Ibrahim SA, Abu Hasfa SH, Smqadri SQ, Haik Y.	J Pathog	10.4061/2011/650968	2011
Pathogenicity	Action of egg white lysozyme on Clostridium tyrobutyricum.	Wasserfall F, Teuber M.	Appl Environ Microbiol	10.1128/aem.38.2.197-199.1979	1979
Metabolism	Clostridium ljungdahlii represents a microbial production platform based on syngas.	Kopke M, Held C, Hujer S, Liesegang H, Wiezer A, Wollherr A, Ehrenreich A, Liebl W, Gottschalk G, Durre P.	Proc Natl Acad Sci U S A	10.1073/pnas.1004716107	2010
Genetics	Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.	Rodionov DA, Arzamasov AA, Khoroshkin MS, Iablokov SN, Leyn SA, Peterson SN, Novichkov PS, Osterman AL.	Front Microbiol	10.3389/fmicb.2019.01316	2019
	Immune response to Chlamydophila abortus POMP91B protein in the context of different Pathogen Associated Molecular Patterns (PAMP); role of antigen in the orientation of immune response.	Le Moigne V, Robreau G, Mahana W.	Toxins (Basel)	10.3390/toxins1020059	2009
Enzymology	Characterization of a fourth tungsten-containing enzyme from the hyperthermophilic archaeon Pyrococcus furiosus.	Roy R, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.184.24.6952-6956.2002	2002
Metabolism	Disruption of the acetate kinase (ack) gene of Clostridium acetobutylicum results in delayed acetate production.	Kuit W, Minton NP, Lopez-Contreras AM, Eggink G.	Appl Microbiol Biotechnol	10.1007/s00253-011-3848-4	2012
Metabolism	Assessment of heterologous butyrate and butanol pathway activity by measurement of intracellular pathway intermediates in recombinant Escherichia coli.	Fischer CR, Tseng HC, Tai M, Prather KL, Stephanopoulos G.	Appl Microbiol Biotechnol	10.1007/s00253-010-2749-2	2010
Metabolism	Flagellin from Listeria monocytogenes is glycosylated with beta-O-linked N-acetylglucosamine.	Schirm M, Kalmokoff M, Aubry A, Thibault P, Sandoz M, Logan SM.	J Bacteriol	10.1128/jb.186.20.6721-6727.2004	2004
	The Use of Copper as an Antimicrobial Agent in Health Care, Including Obstetrics and Gynecology.	Arendsen LP, Thakar R, Sultan AH.	Clin Microbiol Rev	10.1128/cmr.00125-18	2019
Metabolism	A genomic island in Pseudomonas aeruginosa carries the determinants of flagellin glycosylation.	Arora SK, Bangera M, Lory S, Ramphal R.	Proc Natl Acad Sci U S A	10.1073/pnas.161249198	2001
	Food applications of natural antimicrobial compounds.	Lucera A, Costa C, Conte A, Del Nobile MA.	Front Microbiol	10.3389/fmicb.2012.00287	2012
Metabolism	Parallel processing of substrate correlates with greater functional stability in methanogenic bioreactor communities perturbed by glucose.	Hashsham SA, Fernandez AS, Dollhopf SL, Dazzo FB, Hickey RF, Tiedje JM, Criddle CS.	Appl Environ Microbiol	10.1128/aem.66.9.4050-4057.2000	2000
	Streptococcus salivarius fimbriae are composed of a glycoprotein containing a repeated motif assembled into a filamentous nondissociable structure.	Levesque C, Vadeboncoeur C, Chandad F, Frenette M.	J Bacteriol	10.1128/jb.183.9.2724-2732.2001	2001
Genetics	Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes.	Sebaihia M, Peck MW, Minton NP, Thomson NR, Holden MT, Mitchell WJ, Carter AT, Bentley SD, Mason DR, Crossman L, Paul CJ, Ivens A, Wells-Bennik MH, Davis IJ, Cerdeno-Tarraga AM, Churcher C, Quail MA, Chillingworth T, Feltwell T, Fraser A, Goodhead I, Hance Z, Jagels K, Larke N, Maddison M, Moule S, Mungall K, Norbertczak H, Rabbinowitsch E, Sanders M, Simmonds M, White B, Whithead S, Parkhill J.	Genome Res	10.1101/gr.6282807	2007
	Bacteriocins - exploring alternatives to antibiotics in mastitis treatment.	Pieterse R, Todorov SD.	Braz J Microbiol	10.1590/s1517-83822010000300003	2010
Phylogeny	Analysis of the unexplored features of rrs (16S rDNA) of the Genus Clostridium.	Kalia VC, Mukherjee T, Bhushan A, Joshi J, Shankar P, Huma N.	BMC Genomics	10.1186/1471-2164-12-18	2011
Enzymology	Immobilization with metal hydroxides as a means to concentrate food-borne bacteria for detection by cultural and molecular methods.	Lucore LA, Cullison MA, Jaykus LA.	Appl Environ Microbiol	10.1128/aem.66.5.1769-1776.2000	2000
Enzymology	Purification and molecular characterization of the tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus: the third of a putative five-member tungstoenzyme family.	Roy R, Mukund S, Schut GJ, Dunn DM, Weiss R, Adams MW.	J Bacteriol	10.1128/jb.181.4.1171-1180.1999	1999
Genetics	Characterization of a Ligilactobacillus salivarius Strain Isolated from a Cheese Seal Which Was Last Used in 1936.	Alba C, Arroyo R, Fernandez L, Narbad A, Rodriguez JM.	Foods	10.3390/foods13132005	2024
	Ocins for Food Safety.	Choyam S, Srivastava AK, Shin JH, Kammara R.	Front Microbiol	10.3389/fmicb.2019.01736	2019
Metabolism	Elimination of carbon catabolite repression in Clostridium tyrobutyricum for enhanced butyric acid production from lignocellulosic hydrolysates.	Fu H, Zhang H, Guo X, Yang L, Wang J	Bioresour Technol	10.1016/j.biortech.2022.127320	2022
Pathogenicity	A Potential Prophylactic Probiotic for Inflammatory Bowel Disease: The Overall Investigation of Clostridium tyrobutyricum ATCC25755 Attenuates LPS-Induced Inflammation via Regulating Intestinal Immune Cells.	Xiao Z, Liu L, Jin Y, Pei X, Sun W, Wang M	Mol Nutr Food Res	10.1002/mnfr.202001213	2021
Metabolism	Butyric Acid Generation by Clostridium tyrobutyricum from Low-Moisture Anhydrous Ammonia (LMAA) Pretreated Sweet Sorghum Bagasse.	Stoklosa RJ, Moore C, Latona RJ, Nghiem NP	Appl Biochem Biotechnol	10.1007/s12010-020-03449-w	2020
Biotechnology	Fe3O4@chitosan Microspheres Coating as Cytoprotective Exoskeletons for the Enhanced Production of Butyric Acid With Clostridium tyrobutyricum Under Acid Stress.	Liu T, Jiang C, Zhu L, Jiang L, Huang H	Front Bioeng Biotechnol	10.3389/fbioe.2020.00449	2020
Metabolism	Enhancing plasmid transformation efficiency and enabling CRISPR-Cas9/Cpf1-based genome editing in Clostridium tyrobutyricum.	Zhang J, Hong W, Guo L, Wang Y, Wang Y	Biotechnol Bioeng	10.1002/bit.27435	2020
Metabolism	Butyric acid production from spent coffee grounds by engineered Clostridium tyrobutyricum overexpressing galactose catabolism genes.	He F, Qin S, Yang Z, Bai X, Suo Y, Wang J	Bioresour Technol	10.1016/j.biortech.2020.122977	2020
	Direct conversion of untreated cane molasses into butyric acid by engineered Clostridium tyrobutyricum.	Guo X, Fu H, Feng J, Hu J, Wang J	Bioresour Technol	10.1016/j.biortech.2020.122764	2020
Metabolism	Enhanced butyric acid production using mixed biomass of brown algae and rice straw by Clostridium tyrobutyricum ATCC25755.	Oh HJ, Kim KY, Lee KM, Lee SM, Gong G, Oh MK, Um Y	Bioresour Technol	10.1016/j.biortech.2018.11.037	2018
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from undetoxified corncob acid hydrolysate.	Suo Y, Liao Z, Qu C, Fu H, Wang J	Bioresour Technol	10.1016/j.biortech.2018.09.095	2018
Biotechnology	Bioaugmentation with Clostridium tyrobutyricum to improve butyric acid production through direct rice straw bioconversion.	Chi X, Li J, Wang X, Zhang Y, Leu SY, Wang Y	Bioresour Technol	10.1016/j.biortech.2018.04.120	2018
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio.	Suo Y, Ren M, Yang X, Liao Z, Fu H, Wang J	Appl Microbiol Biotechnol	10.1007/s00253-018-8954-0	2018
Biotechnology	Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL.	Suo Y, Fu H, Ren M, Yang X, Liao Z, Wang J	Bioresour Technol	10.1016/j.biortech.2017.11.059	2017
Metabolism	Fermentative hydrogen production from Jerusalem artichoke by Clostridium tyrobutyricum expressing exo-inulinase gene.	Jiang L, Wu Q, Xu Q, Zhu L, Huang H	Sci Rep	10.1038/s41598-017-07207-7	2017
Metabolism	Enhanced butyric acid tolerance and production by Class I heat shock protein-overproducing Clostridium tyrobutyricum ATCC 25755.	Suo Y, Luo S, Zhang Y, Liao Z, Wang J	J Ind Microbiol Biotechnol	10.1007/s10295-017-1939-7	2017
Metabolism	In situ esterification and extractive fermentation for butyl butyrate production with Clostridium tyrobutyricum.	Zhang ZT, Taylor S, Wang Y	Biotechnol Bioeng	10.1002/bit.26289	2017
Metabolism	Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses.	Lee J, Jang YS, Han MJ, Kim JY, Lee SY	mBio	10.1128/mBio.00743-16	2016
Biotechnology	Multilocus variable-number of tandem repeat analysis (MLVA) for Clostridium tyrobutyricum strains isolated from cheese production environment.	Nishihara M, Takahashi H, Sudo T, Kyoi D, Kawahara T, Ikeuchi Y, Fujita T, Kuda T, Kimura B, Yanahira S	Int J Food Microbiol	10.1016/j.ijfoodmicro.2014.08.022	2014
Metabolism	Prevention of late blowing defect by reuterin produced in cheese by a Lactobacillus reuteri adjunct.	Gomez-Torres N, Avila M, Gaya P, Garde S	Food Microbiol	10.1016/j.fm.2014.02.018	2014
Metabolism	The use of high pressure CO2 -facilitated pH swings to enhance in situ product recovery of butyric acid in a two-phase partitioning bioreactor.	Peterson EC, Daugulis AJ	Biotechnol Bioeng	10.1002/bit.25285	2014
Biotechnology	Radiation induces acid tolerance of Clostridium tyrobutyricum and enhances bioproduction of butyric acid through a metabolic switch.	Zhou X, Lu XH, Li XH, Xin ZJ, Xie JR, Zhao MR, Wang L, Du WY, Liang JP	Biotechnol Biofuels	10.1186/1754-6834-7-22	2014
Genetics	Draft Genome Sequence of Clostridium tyrobutyricum Strain UC7086, Isolated from Grana Padano Cheese with Late-Blowing Defect.	Bassi D, Fontana C, Gazzola S, Pietta E, Puglisi E, Cappa F, Cocconcelli PS	Genome Announc	10.1128/genomeA.00614-13	2013
Genetics	Genome Sequence of Clostridium tyrobutyricum ATCC 25755, a Butyric Acid-Overproducing Strain.	Jiang L, Zhu L, Xu X, Li Y, Li S, Huang H	Genome Announc	10.1128/genomeA.00308-13	2013
Biotechnology	Diversity of Streptococcus thermophilus in bacteriocin production; inhibitory spectrum and occurrence of thermophilin genes.	Rossi F, Marzotto M, Cremonese S, Rizzotti L, Torriani S	Food Microbiol	10.1016/j.fm.2013.02.006	2013
Biotechnology	Acetate adaptation of clostridia tyrobutyricum for improved fermentation production of butyrate.	Jaros AM, Rova U, Berglund KA	Springerplus	10.1186/2193-1801-2-47	2013
	Co-culturing a novel Bacillus strain with Clostridium tyrobutyricum ATCC 25755 to produce butyric acid from sucrose.	Dwidar M, Kim S, Jeon BS, Um Y, Mitchell RJ, Sang BI	Biotechnol Biofuels	10.1186/1754-6834-6-35	2013
Metabolism	Effects of different replicons in conjugative plasmids on transformation efficiency, plasmid stability, gene expression and n-butanol biosynthesis in Clostridium tyrobutyricum.	Yu M, Du Y, Jiang W, Chang WL, Yang ST, Tang IC	Appl Microbiol Biotechnol	10.1007/s00253-011-3736-y	2011
Metabolism	Effects of ptb knockout on butyric acid fermentation by Clostridium tyrobutyricum.	Zhang Y, Yu M, Yang ST	Biotechnol Prog	10.1002/btpr.730	2011
Metabolism	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production.	Yu M, Zhang Y, Tang IC, Yang ST	Metab Eng	10.1016/j.ymben.2011.04.002	2011
	Control and optimization of Clostridium tyrobutyricum ATCC 25755 adhesion into fibrous matrix in a fibrous bed bioreactor.	Jiang L, Wang J, Liang S, Cai J, Xu Z	Appl Biochem Biotechnol	10.1007/s12010-011-9236-9	2011
Pathogenicity	Continuous hydrogen and butyric acid fermentation by immobilized Clostridium tyrobutyricum ATCC 25755: effects of the glucose concentration and hydraulic retention time.	Mitchell RJ, Kim JS, Jeon BS, Sang BI	Bioresour Technol	10.1016/j.biortech.2009.05.046	2009
Metabolism	Production of butyric acid from glucose and xylose with immobilized cells of Clostridium tyrobutyricum in a fibrous-bed bioreactor.	Jiang L, Wang J, Liang S, Wang X, Cen P, Xu Z	Appl Biochem Biotechnol	10.1007/s12010-008-8305-1	2008
Biotechnology	Determination of spore inactivation during thermal and pressure-assisted thermal processing using FT-IR spectroscopy.	Subramanian A, Ahn J, Balasubramaniam VM, Rodriguez-Saona L	J Agric Food Chem	10.1021/jf0622174	2006
Enzymology	Construction and characterization of pta gene-deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid fermentation.	Zhu Y, Liu X, Yang ST	Biotechnol Bioeng	10.1002/bit.20354	2005
Biotechnology	Inhibition of Clostridium tyrobutyricum in Vidiago cheese by Lactococcus lactis ssp. lactis IPLA 729, a nisin Z producer.	Rilla N, Martinez B, Delgado T, Rodriguez A	Int J Food Microbiol	10.1016/s0168-1605(02)00478-6	2003
Enzymology	Cloning and sequencing of the central region of the flagellin gene from the Gram-positive bacterium Clostridium tyrobutyricum ATCC 25755.	Arnold F, Bedouet L, Batina P, Robreau G	Microbiol Immunol	10.1111/j.1348-0421.1999.tb02365.x	1999
Metabolism	Evidence for an heterogeneous glycosylation of the Clostridium tyrobutyricum ATCC 25755 flagellin.	Bedouet L, Arnold F, Robreau G, Batina P, Talbot F, Binet A	Microbios		1998
Enzymology	Biochemical and immunological analyses of the flagellin of Clostridium tyrobutyricum ATCC 25755.	Arnold F, Bedouet L, Batina P, Robreau G, Talbot F, Lecher P, Malcoste R	Microbiol Immunol	10.1111/j.1348-0421.1998.tb01965.x	1998
	Long-Chain Polyphosphates Inhibit Growth of Clostridium tyrobutyricum in Processed Cheese Spreads.	Loessner MJ, Maier SK, Schiwek P, Scherer S	J Food Prot	10.4315/0362-028X-60.5.493	1997
Enzymology	Production of monoclonal antibodies against the outer cell wall of Clostridium tyrobutyricum.	Talbot F, Robreau G, Gueguen F, Malcoste R	Hybridoma	10.1089/hyb.1994.13.45	1994
Transcriptome	Transcriptome analysis reveals reasons for the low tolerance of Clostridium tyrobutyricum to furan derivatives.	Suo Y, Li W, Wan L, Luo L, Liu S, Qin S, Wang J	Appl Microbiol Biotechnol	10.1007/s00253-022-12281-7	2022
Transcriptome	Deciphering of the Mannitol Metabolism Pathway in Clostridium tyrobutyricum ATCC 25755 by Comparative Transcriptome Analysis.	Fu H, Yang L, Zhang H, Wang J	Appl Biochem Biotechnol	10.1007/s12010-022-04209-8	2022
Phylogeny	Wukongibacter baidiensis gen. nov., sp. nov., an anaerobic bacterium isolated from hydrothermal sulfides, and proposal for the reclassification of the closely related Clostridium halophilum and Clostridium caminithermale within Maledivibacter gen. nov. and Paramaledivibacter gen. nov., respectively.	Li G, Zeng X, Liu X, Zhang X, Shao Z.	Int J Syst Evol Microbiol	10.1099/ijsem.0.001355	2016
Phylogeny	Description of Christensenella minuta gen. nov., sp. nov., isolated from human faeces, which forms a distinct branch in the order Clostridiales, and proposal of Christensenellaceae fam. nov.	Morotomi M, Nagai F, Watanabe Y.	Int J Syst Evol Microbiol	10.1099/ijs.0.026989-0	2012
Biotechnology	Clostridium caseinilyticum sp. nov., a close relative of Clostridium tepidum and Clostridium sporogenes, isolated from spoiled cheese and silage.	Shani N, Zago M, Berthoud H, Marzohl D, Michellod E, Gindro K, Giraffa G, Arias-Roth E.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006875	2025
Phylogeny	Clostridium algifaecis sp. nov., an anaerobic bacterial species from decomposing algal scum.	Wu YF, Zheng H, Wu QL, Yang H, Liu SJ.	Int J Syst Evol Microbiol	10.1099/ijs.0.064345-0	2014
Phylogeny	Clostridium pabulibutyricum sp. nov., a butyric-acid-producing organism isolated from high-moisture grass silage.	Kobayashi H, Nakasato T, Sakamoto M, Ohtani Y, Terada F, Sakai K, Ohkuma M, Tohno M	Int J Syst Evol Microbiol	10.1099/ijsem.0.002387	2017

References

#1182	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 2637
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#35775	; Curators of the CIP;
#58078	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 48315
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#123702	Collection of Institut Pasteur ; Curators of the CIP; CIP 105092
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

Rate our new design

Content

About us

Clostridium tyrobutyricum (DSM 2637, ATCC 25755, NCIMB 10635)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Metabolite utilization

Metabolite production

Enzymes

API zym

Isolation, sampling and environmental information

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000429805

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

Help

Social Media