Treponema denticola (JCM 8226, ATCC 33521, CIP 103917)

Name: Treponema denticola (JCM 8226, ATCC 33521, CIP 103917)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 165775

Type strain

Culture col. no. JCM 8226 ATCC 33521 CIP 103917

NCBI tax ID(s) 999429 158

Special Collections JCM CIP

Links

Treponema denticola JCM 8226 is a mesophilic prokaryote that was isolated from Human oral cavity.

mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 92964

ATCC 33521,JCM 8226

@ref 20215

Last LPSN update 2025-12-16 10:09:45

Domain Pseudomonadati

Phylum Spirochaetota

Class Spirochaetia

Order Spirochaetales

Family Treponemataceae

Genus Treponema

Species Treponema denticola

Full scientific name Treponema denticola (ex Flügge 1886) Chan et al. 1993

Synonyms (1)

"Treponema denticola"

BacDive ID	Other strains from **Treponema denticola** (4)	Type strain
14344	T. denticola DSM 14222, ATCC 35405, JCM 8153, CIP 103919, ... (type strain)
138912	T. denticola CIP 64.44
165755	T. denticola JCM 8152, ATCC 35404, CIP 103920
165774	T. denticola JCM 8225, ATCC 33520, CIP 103917

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	96.5

Culture and growth conditions

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	anaerobe	91.251

Spore formation

@ref	Spore formation	Confidence
125439		99.5

Isolation, sampling and environmental information

Isolation

67770

Sample typeHuman oral cavity

Taxonmaps

69479

Global distribution of 16S sequence LC007112 (>99% sequence identity) for Treponema denticola from Microbeatlas

Aquatic Samples	521
Soil Samples	517
Animal Samples	28134
Plant Samples	223
Total Samples	29395

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	Trep_dent_ATCC_33521_V1 assembly for Treponema denticola ATCC 33521	scaffold	GCA_000338595	999429.3	2558860187	999429	58.16

Genome browser: GCA_000338595

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
67770	Treponema denticola gene for 16S ribosomal RNA, partial sequence, strain: JCM 8226	LC007112	1506		158
124043	Treponema denticola ATCC 33521 16S ribosomal RNA gene, partial sequence.	JF700256	1497		999429

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Treponema denticola ATCC 33521
NCBI: GCA_000338595

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	99.50	no
125439	motility	BacteriaNetⓘ	no	66.50	no
125439	gram_stain	BacteriaNetⓘ	negative	96.50	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	75.20	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Treponema denticola ATCC 33521
PATRIC: 999429.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	84.53	no
125438	anaerobic	anaerobicⓘ	yes	91.25	no
125438	aerobic	aerobicⓘ	no	96.88	no
125438	spore-forming	spore-formingⓘ	no	79.36	no
125438	thermophilic	thermophileⓘ	no	87.39	yes
125438	flagellated	motile2+ⓘ	yes	58.54	no

Literature

Title	Authors	Journal	DOI	Year
Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola.	Nukaga T, Kokubu E, Okamoto-Shibayama K, Kikuchi Y, Furusawa M, Muramatsu T, Ishihara K.	Front Dent Med	10.3389/fdmed.2025.1543535	2025
Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes.	Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M.	PLoS One	10.1371/journal.pone.0270198	2022
Comparative analysis of motility and other properties of Treponema denticola strains.	Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F.	Microb Pathog	10.1016/j.micpath.2016.11.021	2017
Multiple enzymes can make hydrogen sulfide from cysteine in Treponema denticola.	Phillips L, Chu L, Kolodrubetz D.	Anaerobe	10.1016/j.anaerobe.2020.102231	2020
Dentilisin involvement in coaggregation between Treponema denticola and Tannerella forsythia.	Sano Y, Okamoto-Shibayama K, Tanaka K, Ito R, Shintani S, Yakushiji M, Ishihara K.	Anaerobe	10.1016/j.anaerobe.2014.08.008	2014
Multiplex real-time PCR detection and relative quantification of periodontal pathogens.	Coffey J, Choudhry M, Shlossman M, Makin IRS, Singh VK.	Clin Exp Dent Res	10.1002/cre2.37	2016
Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola.	Tanaka-Kumazawa K, Kikuchi Y, Sano-Kokubun Y, Shintani S, Yakushiji M, Kuramitsu HK, Ishihara K.	BMC Oral Health	10.1186/s12903-016-0243-7	2016
Multilocus sequence analysis of Treponema denticola strains of diverse origin.	Mo S, You M, Su YC, Lacap-Bugler DC, Huo YB, Smith GJ, Leung WK, Leung WK, Leung WK, Watt RM.	BMC Microbiol	10.1186/1471-2180-13-24	2013
Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine.	Kim MJ, Lee BC, Hwang KY, Gladyshev VN, Kim HY.	Biochem Biophys Res Commun	10.1016/j.bbrc.2015.04.082	2015
Multilocus Sequence Analysis of Phylogroup 1 and 2 Oral Treponeme Strains.	Huo YB, Chan Y, Lacap-Bugler DC, Mo S, Woo PCY, Leung WK, Watt RM.	Appl Environ Microbiol	10.1128/aem.02499-16	2017
Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex.	Goetting-Minesky MP, Godovikova V, Li JJ, Seshadrinathan S, Timm JC, Kamodia SS, Fenno JC.	Mol Oral Microbiol	10.1111/omi.12013	2013
The gain and loss of chromosomal integron systems in the Treponema species.	Wu YW, Doak TG, Ye Y.	BMC Evol Biol	10.1186/1471-2148-13-16	2013
Treponema denticola suppresses expression of human {beta}-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis.	Shin JE, Kim YS, Oh JE, Min BM, Choi Y.	Infect Immun	10.1128/iai.00808-09	2010
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.	Jun HK, Jung YJ, Ji S, An SJ, Choi BK.	Cell Death Differ	10.1038/cdd.2017.167	2018
Treponema denticola is resistant to human beta-defensins.	Brissette CA, Lukehart SA.	Infect Immun	10.1128/iai.70.7.3982-3984.2002	2002
Mitogenic activity of the outer membrane of Treponema denticola.	Schade SZ, Yotis WW, Gopalsami C, Simonson LG.	Microbios		1998
Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.	McDowell JV, Lankford J, Stamm L, Sadlon T, Gordon DL, Marconi RT.	Infect Immun	10.1128/iai.73.11.7126-7132.2005	2005
Two paralogous families of a two-gene subtilisin operon are widely distributed in oral treponemes.	Correia FF, Plummer AR, Ellen RP, Wyss C, Boches SK, Galvin JL, Paster BJ, Dewhirst FE.	J Bacteriol	10.1128/jb.185.23.6860-6869.2003	2003
N-acetylcysteine and the human serum components that inhibit bacterial invasion of gingival epithelial cells prevent experimental periodontitis in mice.	Alam J, Baek KJ, Choi YS, Kim YC, Choi Y.	J Periodontal Implant Sci	10.5051/jpis.2014.44.6.266	2014
Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.	Simonson LG, Rouse RF, Bockowski SW.	Infect Immun	10.1128/iai.56.1.60-63.1988	1988
Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola.	Roberts MC, Chung WO, Roe DE.	Antimicrob Agents Chemother	10.1128/aac.40.7.1690	1996
Identification of seven Treponema species in health- and disease-associated dental plaque by nested PCR.	Willis SG, Smith KS, Dunn VL, Gapter LA, Riviere KH, Riviere GR.	J Clin Microbiol	10.1128/jcm.37.3.867-869.1999	1999
A major antigen on the outer envelope of a human oral spirochete, Treponema denticola.	Umemoto T, Namikawa I, Suido H, Asai S.	Infect Immun	10.1128/iai.57.8.2470-2474.1989	1989
Induction of osteoclastogenesis and matrix metalloproteinase expression by the lipooligosaccharide of Treponema denticola.	Choi BK, Lee HJ, Kang JH, Jeong GJ, Min CK, Yoo YJ.	Infect Immun	10.1128/iai.71.1.226-233.2003	2003
Enzyme profiles of oral spirochetes in RapID-ANA system.	Syed SA, Salvador SL, Loesche WJ.	J Clin Microbiol	10.1128/jcm.26.10.2226-2228.1988	1988
Ceruloplasmin can substitute for rabbit serum in stimulating the growth of Treponema denticola.	Suzuki M, Loesche WJ.	Infect Immun	10.1128/iai.57.2.643-644.1989	1989
Quantitative immunoassay of Treponema denticola serovar C in adult periodontitis.	Simonson LG, Goodman CH, Morton HE.	J Clin Microbiol	10.1128/jcm.28.7.1493-1496.1990	1990
Effect of fluoride on Treponema denticola.	Hughes CA, Yotis WW.	Infect Immun	10.1128/iai.52.3.914-915.1986	1986
Cloning and expression of the aspartate carbamoyltransferase gene from Treponema denticola.	Ishihara K, Ishihara M, Takazoe I, Okuda K.	Appl Environ Microbiol	10.1128/aem.58.10.3399-3403.1992	1992
Pathogen-related oral spirochetes from dental plaque are invasive.	Riviere GR, Weisz KS, Adams DF, Thomas DD.	Infect Immun	10.1128/iai.59.10.3377-3380.1991	1991
Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium spp.	Kolenbrander PE, Parrish KD, Andersen RN, Greenberg EP.	Infect Immun	10.1128/iai.63.12.4584-4588.1995	1995
Highly conserved surface proteins of oral spirochetes as adhesins and potent inducers of proinflammatory and osteoclastogenic factors.	Jun HK, Kang YM, Lee HR, Lee SH, Choi BK.	Infect Immun	10.1128/iai.01128-07	2008
Quantitative relationship of Treponema denticola to severity of periodontal disease.	Simonson LG, Goodman CH, Bial JJ, Morton HE.	Infect Immun	10.1128/iai.56.4.726-728.1988	1988
A rapid method for extraction and purification of DNA from dental plaque.	Parrish KD, Greenberg EP.	Appl Environ Microbiol	10.1128/aem.61.11.4120-4123.1995	1995
Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis.	Riviere GR, Weisz KS, Simonson LG, Lukehart SA.	Infect Immun	10.1128/iai.59.8.2653-2657.1991	1991
Biochemical properties of the outer membrane of Treponema denticola.	Yotis WW, Sharma VK, Gopalsami C, Chegini S, McNulty J, Hoerman K, Keene J, Simonson LG.	J Clin Microbiol	10.1128/jcm.29.7.1397-1406.1991	1991
Cloning and characterization of a gene (mspA) encoding the major sheath protein of Treponema maltophilum ATCC 51939(T).	Heuner K, Choi BK, Schade R, Moter A, Otto A, Gobel UB.	J Bacteriol	10.1128/jb.181.3.1025-1029.1999	1999
Rapid and accurate diagnosis of human intestinal spirochetosis by fluorescence in situ hybridization.	Schmiedel D, Epple HJ, Loddenkemper C, Ignatius R, Wagner J, Hammer B, Petrich A, Stein H, Gobel UB, Schneider T, Moter A.	J Clin Microbiol	10.1128/jcm.02469-08	2009
Common antigens of Treponema denticola: chemical, physical, and serological characterization.	Jacob E, Nauman RK.	Infect Immun	10.1128/iai.37.2.474-480.1982	1982
Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections.	Lee SH, Kim KK, Choi BK.	Infect Immun	10.1128/iai.73.1.268-276.2005	2005
Phylogenetic analysis of pathogen-related oral spirochetes.	Choi BK, Wyss C, Gobel UB.	J Clin Microbiol	10.1128/jcm.34.8.1922-1925.1996	1996
Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum.	Jewett A, Hume WR, Le H, Huynh TN, Han YW, Cheng G, Shi W.	Infect Immun	10.1128/iai.68.4.1893-1898.2000	2000
Detection of Borrelia burgdorferi sensu lato in lesional skin of patients with erythema migrans and acrodermatitis chronica atrophicans by ospA-specific PCR.	Moter SE, Hofmann H, Wallich R, Simon MM, Kramer MD.	J Clin Microbiol	10.1128/jcm.32.12.2980-2988.1994	1994
Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides.	Schultz CP, Wolf V, Lange R, Mertens E, Wecke J, Naumann D, Zahringer U	J Biol Chem	10.1074/jbc.273.25.15661	1998
Characterization of antisera raised against Treponema denticola (ATCC 33521) whole cell, outer sheath, protoplasmic cylinder, and axial flagella.	Wolf V, Lange R	Zentralbl Bakteriol	10.1016/s0934-8840(11)80594-3	1994
Characterization of monoclonal antibodies to two Treponema denticola serotypes by the indirect fluorescent-antibody assay.	Kearns EA, Simonson LG, Schutt RW, Johnson MJ, Neil LC	Microbios		1991
Activation of bone marrow-derived dendritic cells and CD4(+) T cell differentiation by outer membrane vesicles of periodontal pathogens.	Lim Y, Kim HY, An SJ, Choi BK	J Oral Microbiol	10.1080/20002297.2022.2123550	2022

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Treponema denticola (JCM 8226, ATCC 33521, CIP 103917)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Isolation, sampling and environmental information

Isolation

Taxonmaps

Interaction and safety

Sequence information

Genome sequences

Genome browser: GCA_000338595

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

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