Treponema denticola (DSM 14222, ATCC 35405, JCM 8153)

Name: Treponema denticola (DSM 14222, ATCC 35405, JCM 8153)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14344

Type strain

Culture col. no. DSM 14222 ATCC 35405 JCM 8153 CIP 103919 KCTC 15104

NCBI tax ID(s) 243275 158

Special Collections DSMZ JCM KCTC CIP

History DSMZ <- ATCC; ATCC 35405 <- E. C. S. Chan; JCM <-- ATCC 35405 <-- E. C. S. Chan strain a.

Links

Treponema denticola DSM 14222 is an anaerobe human pathogen that was isolated from human periodontal pocket.

anaerobe human pathogen genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 41060

ATCC 35405,CIP 103919,ATCC 51460,DSM 7334,DSM 14222,JCM 8153

@ref 20215

Last LPSN update 2026-05-29 08:28:16

Domain Bacteria

Phylum Spirochaetota

Class Spirochaetia

Order Spirochaetales

Family Treponemataceae

Genus Treponema

Species Treponema denticola

Full scientific name Treponema denticola (ex Flügge 1886) Chan et al. 1993

Synonyms (1)

"Treponema denticola"

BacDive ID	Other strains from **Treponema denticola** (4)	Type strain
138912	T. denticola CIP 64.44
165755	T. denticola JCM 8152, ATCC 35404, CIP 103920
165774	T. denticola JCM 8225, ATCC 33520, CIP 103917
165775	T. denticola JCM 8226, ATCC 33521, CIP 103917

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	90.712

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
5260	TREPONEMA DENTICOLA MEDIUM (DSMZ Medium 909)		Medium recipe at MediaDive	Name: TREPONEMA DENTICOLA MEDIUM (DSMZ Medium 909) Composition: Brain heart infusion broth 11.9617 g/l Trypticase 9.56938 g/l Agar 2.87081 g/l Yeast extract 2.39234 g/l Glucose 1.91388 g/l NaHCO3 1.91387 g/l L-Cysteine HCl 0.956938 g/l Na-thioglycolate 0.478469 g/l L-Asparagine 0.239234 g/l Thiamine pyrophosphate 0.00574161 g/l Valeric acid DL-2-Methylbutyric acid Isovaleric acid KOH Isobutyric acid Rabbit serum Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
5260	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
5260	anaerobe
125438	anaerobe	91.251
125439	facultative anaerobe	92.725

Spore formation

@ref	Spore formation	Confidence
125439		99.434

Compound production

5260

Compoundproline iminopeptidase

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	adipate degradation	100	2 of 2
66794	ethanol fermentation	100	2 of 2
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	dolichol and dolichyl phosphate biosynthesis	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	L-lactaldehyde degradation	100	3 of 3
66794	cardiolipin biosynthesis	100	7 of 7
66794	chorismate metabolism	88.89	8 of 9
66794	vitamin B12 metabolism	88.24	30 of 34
66794	lipoate biosynthesis	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	starch degradation	80	8 of 10
66794	peptidoglycan biosynthesis	80	12 of 15
66794	glycine betaine biosynthesis	80	4 of 5
66794	NAD metabolism	77.78	14 of 18
66794	phosphatidylethanolamine bioynthesis	76.92	10 of 13
66794	glycolysis	76.47	13 of 17
66794	glycogen biosynthesis	75	3 of 4
66794	ppGpp biosynthesis	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	acetate fermentation	75	3 of 4
66794	photosynthesis	71.43	10 of 14
66794	d-mannose degradation	66.67	6 of 9
66794	methane metabolism	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	selenocysteine biosynthesis	66.67	4 of 6
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	purine metabolism	65.96	62 of 94
66794	pyrimidine metabolism	64.44	29 of 45
66794	gluconeogenesis	62.5	5 of 8
66794	degradation of sugar alcohols	62.5	10 of 16
66794	methylglyoxal degradation	60	3 of 5
66794	hydrogen production	60	3 of 5
66794	methionine metabolism	57.69	15 of 26
66794	glutamate and glutamine metabolism	57.14	16 of 28
66794	propanol degradation	57.14	4 of 7
66794	ubiquinone biosynthesis	57.14	4 of 7
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	CO2 fixation in Crenarchaeota	55.56	5 of 9
66794	serine metabolism	55.56	5 of 9
66794	oxidative phosphorylation	53.85	49 of 91
66794	phenylalanine metabolism	53.85	7 of 13
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	Entner Doudoroff pathway	50	5 of 10
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	isoprenoid biosynthesis	50	13 of 26
66794	kanosamine biosynthesis II	50	1 of 2
66794	degradation of hexoses	50	9 of 18
66794	threonine metabolism	50	5 of 10
66794	CMP-KDO biosynthesis	50	2 of 4
66794	non-pathway related	50	19 of 38
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	biotin biosynthesis	50	2 of 4
66794	suberin monomers biosynthesis	50	1 of 2
66794	ketogluconate metabolism	50	4 of 8
66794	butanoate fermentation	50	2 of 4
66794	coenzyme A metabolism	50	2 of 4
66794	alanine metabolism	48.28	14 of 29
66794	vitamin B1 metabolism	46.15	6 of 13
66794	valine metabolism	44.44	4 of 9
66794	heme metabolism	42.86	6 of 14
66794	lipid metabolism	41.94	13 of 31
66794	histidine metabolism	41.38	12 of 29
66794	cellulose degradation	40	2 of 5
66794	ethylmalonyl-CoA pathway	40	2 of 5
66794	3-chlorocatechol degradation	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	O-antigen biosynthesis	40	2 of 5
66794	tryptophan metabolism	39.47	15 of 38
66794	leucine metabolism	38.46	5 of 13
66794	vitamin B6 metabolism	36.36	4 of 11
66794	degradation of sugar acids	36	9 of 25
66794	tetrahydrofolate metabolism	35.71	5 of 14
66794	citric acid cycle	35.71	5 of 14
66794	tyrosine metabolism	35.71	5 of 14
66794	UDP-GlcNAc biosynthesis	33.33	1 of 3
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	nitrate assimilation	33.33	3 of 9
66794	molybdenum cofactor biosynthesis	33.33	3 of 9
66794	degradation of pentoses	32.14	9 of 28
66794	sulfate reduction	30.77	4 of 13
66794	urea cycle	30.77	4 of 13
66794	coenzyme M biosynthesis	30	3 of 10
66794	propionate fermentation	30	3 of 10
66794	arginine metabolism	29.17	7 of 24
66794	glutathione metabolism	28.57	4 of 14
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	cysteine metabolism	27.78	5 of 18
66794	pentose phosphate pathway	27.27	3 of 11
66794	metabolism of disaccharids	27.27	3 of 11
66794	proline metabolism	27.27	3 of 11
66794	ascorbate metabolism	27.27	6 of 22
66794	flavin biosynthesis	26.67	4 of 15
66794	toluene degradation	25	1 of 4
66794	lactate fermentation	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	dTDPLrhamnose biosynthesis	25	2 of 8
66794	isoleucine metabolism	25	2 of 8
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	25	2 of 8
66794	phenylpropanoid biosynthesis	23.08	3 of 13
66794	lipid A biosynthesis	22.22	2 of 9
66794	4-hydroxymandelate degradation	22.22	2 of 9
66794	polyamine pathway	21.74	5 of 23
66794	lysine metabolism	21.43	9 of 42

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Periodontal pocket

Isolation

@ref	Sample type	Host species	Geographic location	Country	Country ISO 3 Code	Continent	Latitude	Longitude
5260	human periodontal pocket	Homo sapiens	Montreal	Canada	CAN	North America	45.5017	-73.5673 45.5017/-73.5673
67770	Human oral cavity	Homo sapiens

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Pathogenicity animal	Biosafety level	Biosafety level comment
5260			2	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM818v1 assembly for Treponema denticola ATCC 35405	complete	GCA_000008185	243275.19	637000327	243275	99.21
66792	Treponema denticola ATCC 35405	complete		243275.7		243275	54.1

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Treponema denticola strain ATCC35405 16S ribosomal RNA gene, partial sequence	AF139203	1518	158
20218	Treponema denticola strain 35405 16S ribosomal RNA gene, partial sequence; 16S-23S intergenic spacer region and tRNA-Ile gene, complete sequence; 23S ribosomal RNA and 16S ribosomal RNA genes, partial sequence; 16S-23S intergenic spacer region and tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequence	AH010026	424	158
20218	Treponema denticola gene for 16S ribosomal RNA, partial sequence, strain: JCM 8153	AB621358	1506	158

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM818v1 assembly for Treponema denticola ATCC 35405
NCBI: GCA_000008185

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	92.73	no
125439	gram_stain	BacteriaNetⓘ	negative	90.71	no
125439	spore_formation	BacteriaNetⓘ	no	99.43	no
125439	motility	BacteriaNetⓘ	no	76.39	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Treponema denticola ATCC 35405 ATCC 35405
NCBI: GCA_000008185.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	84.15	no
125438	anaerobic	anaerobicⓘ	yes	91.25	yes
125438	aerobic	aerobicⓘ	no	96.90	no
125438	spore-forming	spore-formingⓘ	no	79.43	no
125438	thermophilic	thermophileⓘ	no	88.88	yes
125438	flagellated	motile2+ⓘ	yes	58.54	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	The Presence of Treponema spp. in Equine Hoof Canker Biopsies and Skin Samples from Bovine Digital Dermatitis Lesions.	Marcekova P, Mad'ar M, Stykova E, Kacirova J, Sondorova M, Mudron P, Zert Z.	Microorganisms	10.3390/microorganisms9112190	2021
	Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases.	Giannini G, Ragusa I, Nardone GN, Soldi S, Elli M, Valenti P, Rosa L, Marra E, Stoppoloni D, Merlo Pich E.	Int J Dent	10.1155/2022/5007930	2022
	Non-Invasive Luciferase Imaging of Type I Interferon Induction in a Transgenic Mouse Model of Biomaterial Associated Bacterial Infections: Microbial Specificity and Inter-Bacterial Species Interactions.	Rahim MI, Winkel A, Lienenklaus S, Stumpp NS, Szafranski SP, Kommerein N, Willbold E, Reifenrath J, Mueller PP, Eisenburger M, Stiesch M.	Microorganisms	10.3390/microorganisms8101624	2020
	Bacterial-Specific Induction of Inflammatory Cytokines Significantly Decreases upon Dual Species Infections of Implant Materials with Periodontal Pathogens in a Mouse Model.	Rahim MI, Winkel A, Ingendoh-Tsakmakidis A, Lienenklaus S, Falk CS, Eisenburger M, Stiesch M.	Biomedicines	10.3390/biomedicines10020286	2022
	Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases.	Giannini G, Ragusa I, Nardone GN, Soldi S, Elli M, Valenti P, Rosa L.	Gels	10.3390/gels9080607	2023
Phylogeny	Multilocus Sequence Analysis of Phylogroup 1 and 2 Oral Treponeme Strains.	Huo YB, Chan Y, Lacap-Bugler DC, Mo S, Woo PCY, Leung WK, Watt RM.	Appl Environ Microbiol	10.1128/aem.02499-16	2017
	Rapid Multiplex Real-Time PCR Method for the Detection and Quantification of Selected Cariogenic and Periodontal Bacteria.	Lochman J, Zapletalova M, Poskerova H, Izakovicova Holla L, Borilova Linhartova P.	Diagnostics (Basel)	10.3390/diagnostics10010008	2019
	Evaluation of microbiota associated with Herpesviruses in active sites of generalized aggressive periodontitis.	Passariello C, Gigola P, Testarelli L, Puttini M, Schippa S, Petti S.	Ann Stomatol (Roma)	10.11138/ads/2017.8.2.071	2017
Metabolism	Phyloproteomic and functional analyses do not support a split in the genus Borrelia (phylum Spirochaetes).	Estrada-Pena A, Cabezas-Cruz A.	BMC Evol Biol	10.1186/s12862-019-1379-2	2019
	Quantitative molecular detection of putative periodontal pathogens in clinically healthy and periodontally diseased subjects.	Gohler A, Hetzer A, Holtfreter B, Geisel MH, Schmidt CO, Steinmetz I, Kocher T.	PLoS One	10.1371/journal.pone.0099244	2014
	Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola.	Nukaga T, Kokubu E, Okamoto-Shibayama K, Kikuchi Y, Furusawa M, Muramatsu T, Ishihara K.	Front Dent Med	10.3389/fdmed.2025.1543535	2025
	Microbial Coaggregation in the Oral Cavity: Molecular Interactions and Current Insights.	Oogai Y, Tanaka Y, Nakata M.	Int J Mol Sci	10.3390/ijms262110552	2025
	The unique histidine kinase, AtcS, regulates motility and pathogenicity of the periodontal pathobiont, Treponema denticola.	Abdallah DN, Hinson AN, Moylan AD, Patel DT, Zhu B, Marconi RT, Miller DP.	Infect Immun	10.1128/iai.00112-25	2025
	ComFB, a widespread family of c-di-NMP receptor proteins.	Samir S, Elshereef AA, Alva V, Hahn J, Eck F, Celma L, Lopes ES, Thormann K, Dubnau D, Galperin MY, Selim KA.	Proc Natl Acad Sci U S A	10.1073/pnas.2513041122	2025
	The transcriptomic response to cannabidiol of Treponema denticola, a phytocannabinoid-resistant periodontal pathogen.	Tan J, Lamont GJ, Sekula M, Hong H, Sloan L, Scott DA.	J Clin Periodontol	10.1111/jcpe.13892	2024
	Enhanced transformation efficiency in Treponema denticola enabled by SyngenicDNA-based plasmids lacking restriction-modification target motifs.	Johnston CD, Goetting-Minesky MP, Kennedy K, Godovikova V, Zayed SM, Roberts RJ, Fenno JC.	Mol Oral Microbiol	10.1111/omi.12441	2023
	Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola.	Moylan AD, Patel DT, O'Brien C, Schuler EJA, Hinson AN, Marconi RT, Miller DP.	Mol Oral Microbiol	10.1111/omi.12458	2024
	Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola.	Miyai-Murai Y, Okamoto-Shibayama K, Sato T, Kikuchi Y, Kokubu E, Potempa J, Ishihara K.	Mol Oral Microbiol	10.1111/omi.12406	2023
	A Systematic Review of In Vitro Studies Using Microchip Platforms for Identifying Periodontopathogens from the Red Complex.	Ardila CM, Jimenez-Arbelaez GA, Vivares-Builes AM.	Dent J (Basel)	10.3390/dj11110245	2023
	Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography.	Kamarajan P, Timm JC, Goetting-Minesky MP, Malone ET, Ganther S, Radaic A, Tafolla C, Fenno JC, Kapila YL.	Bio Protoc	10.21769/bioprotoc.4970	2024
	Evaluation of Antibacterial Activity against Nosocomial Pathogens of an Enzymatically Derived alpha-Aminophosphonates Possessing Coumarin Scaffold.	Kowalczyk P, Koszelewski D, Brodzka A, Kramkowski K, Ostaszewski R.	Int J Mol Sci	10.3390/ijms241914886	2023
	Real-Time PCR Method as Diagnostic Tool for Detection of Periodontal Pathogens in Patients with Periodontitis.	Kuret S, Kalajzic N, Ruzdjak M, Grahovac B, Jezina Buselic MA, Sardelic S, Delic A, Susak L, Sutlovic D.	Int J Mol Sci	10.3390/ijms25105097	2024
	Highly accurate measurement of the relative abundance of oral pathogenic bacteria using colony-forming unit-based qPCR.	Hwang J, Lee JH, Kim YJ, Hwang I, Kim YY, Kim HS, Park DY.	J Periodontal Implant Sci	10.5051/jpis.2304520226	2024
	Assessment of periodontitis vaccine using three different bacterial outer membrane vesicles in canine model.	Nakao R, Yamaguchi T, Shibasaki H, Saeki J, Takahashi A, Tominaga R, Abe K, Akeda Y, Nakagawa-Nakamura T, Nishino T, Ishihara K, Jinno-Oue A, Inoue S.	mSphere	10.1128/msphere.01033-24	2025
	Protein targets in red complex pathogens for catechin.	Cibikkarthik T, Smiline Girija AS, Vijayashree Priyadharsini J.	Bioinformation	10.6026/973206300171105	2021
	A bipartite bacterial virulence factor targets the complement system and neutrophil activation.	Kurniyati K, Clark ND, Wang H, Deng Y, Sze CW, Visser MB, Malkowski MG, Li C.	EMBO J	10.1038/s44318-024-00342-8	2025
	Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis.	Aravindraja C, Jeepipalli S, Vekariya KM, Botello-Escalante R, Chan EKL, Kesavalu L.	Int J Mol Sci	10.3390/ijms241512105	2023
	Injectable Platelet-Rich Fibrin and Advanced Platelet-Rich Fibrin Demonstrate Enhanced Anti-Biofilm Effect Compared to Enamel Matrix Derivatives on Decontaminated Titanium Surfaces.	Varghese J, Ramenzoni LL, Shenoy PA, Schmidlin PR, Mehrotra S, Kamath V.	Dent J (Basel)	10.3390/dj12060175	2024
	Novel Indigenous Probiotic Lactobacillus reuteri Strain Produces Anti-biofilm Reuterin against Pathogenic Periodontal Bacteria.	Widyarman AS, Theodorea CF.	Eur J Dent	10.1055/s-0041-1731591	2022
	Genetic Manipulations of Oral Spirochete Treponema denticola.	Kurniyati K, Li C.	Methods Mol Biol	10.1007/978-1-0716-0939-2_2	2021
	Mucispirillum schaedleri: Biofilm Architecture and Age-Dependent Pleomorphy.	Desjardins A, Zerfas P, Filion D, Palmer RJ, Falcone EL.	Microorganisms	10.3390/microorganisms11092200	2023
	Genistein binding protein targets in dental pathogens.	Vivek Babu B, Smiline Girija AS, Vijayashree Priyadharsini J.	Bioinformation	10.6026/973206300171109	2021
	Lysinoalanine cross-linking is a conserved post-translational modification in the spirochete flagellar hook.	Lynch MJ, Deshpande M, Kurniyati K, Zhang K, James M, Miller M, Zhang S, Passalia FJ, Wunder EA, Charon NW, Li C, Crane BR.	PNAS Nexus	10.1093/pnasnexus/pgad349	2023
	Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-beta Accumulation in Mice.	Wu L, Su X, Tang Z, Jian L, Zhu H, Cheng X, Wu H.	Pathogens	10.3390/pathogens11101150	2022
	Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in Treponema denticola.	Goetting-Minesky MP, Godovikova V, Fenno JC.	Front Cell Infect Microbiol	10.3389/fcimb.2021.668287	2021
Phenotype	High-Frequency Ultrasound for Detecting Periodontal Inflammation: A Preclinical Diagnostic Accuracy Study.	Samal A, Majzoub J, Rodriguez Betancourt A, Webber L, Mazzocco J, Wang HL, Castilho R, Fenno JC, Chan HL, Kripfgans OD.	J Periodontal Res	10.1111/jre.13376	2025
	Nisin, a Probiotic Bacteriocin, Modulates the Inflammatory and Microbiome Changes in Female Reproductive Organs Mediated by Polymicrobial Periodontal Infection.	Ye C, Zhao C, Kuraji R, Gao L, Range H, Kamarajan P, Radaic A, Kapila YL.	Microorganisms	10.3390/microorganisms12081647	2024
	A Multi-Skilled Mathematical Model of Bacterial Attachment in Initiation of Biofilms.	Chathoth K, Fostier L, Martin B, Baysse C, Mahe F.	Microorganisms	10.3390/microorganisms10040686	2022
	Sustainable synthesis of silver nanoparticles from Azadirachta indica: antimicrobial, antioxidant and in silico analysis for periodontal treatment.	Barik B, Satapathy BS, Pattnaik G, Bhavrao DV, Shetty KP.	Front Chem	10.3389/fchem.2024.1489253	2024
	Potential Antimicrobial Use of Cannabidiol in Dentistry: A Scoping Review.	Mederos M, Elizalde-Hernandez A, Francia A, Chisini LA, Isolan CP, Moraes RR, Lund RG, David C.	Dent J (Basel)	10.3390/dj13110519	2025
	The occurrence of Treponema spp. in gingival plaque from dogs with varying degree of periodontal disease.	Nises J, Rosander A, Pettersson A, Backhans A.	PLoS One	10.1371/journal.pone.0201888	2018
	Epithelial-derived interleukin-23 promotes oral mucosal immunopathology.	Kim TS, Ikeuchi T, Theofilou VI, Williams DW, Greenwell-Wild T, June A, Adade EE, Li L, Abusleme L, Dutzan N, Yuan Y, Brenchley L, Bouladoux N, Sakamachi Y, NIDCD/NIDCR Genomics and Computational Biology Core, Palmer RJ, Iglesias-Bartolome R, Trinchieri G, Garantziotis S, Belkaid Y, Valm AM, Diaz PI, Holland SM, Moutsopoulos NM.	Immunity	10.1016/j.immuni.2024.02.020	2024
	Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.	Staton GJ, Clegg SR, Ainsworth S, Armstrong S, Carter SD, Radford AD, Darby A, Wastling J, Hall N, Evans NJ.	PLoS Pathog	10.1371/journal.ppat.1009464	2021
	Identification of Periopathogens in Atheromatous Plaques Obtained from Carotid and Coronary Arteries.	Pavlic V, Peric D, Kalezic IS, Madi M, Bhat SG, Brkic Z, Staletovic D.	Biomed Res Int	10.1155/2021/9986375	2021
Phylogeny	Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis.	Zeng H, Chan Y, Gao W, Leung WK, Watt RM.	Microbiol Spectr	10.1128/spectrum.00701-21	2021
	Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression.	Aravindraja C, Kashef MR, Vekariya KM, Ghanta RK, Karanth S, Chan EKL, Kesavalu L.	Int J Mol Sci	10.3390/ijms23095107	2022
	Transcriptional and functional characterizations of multiple flagellin genes in spirochetes.	Kurniyati K, Chang Y, Liu J, Li C.	Mol Microbiol	10.1111/mmi.14959	2022
Pathogenicity	Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques.	Karhunen PJ, Pessi T, Horkko S, Karhunen V, Goebeler S, Louhelainen AM, Martiskainen M, Haapaniemi T, Lappetelainen J, Ijas T, Lyytikainen LP, Raitoharju E, Sioris T, Tuomisto S, Huhtala H, Wang C, Monaco C, Oksala N, Lehtimaki T, Laaksonen R.	J Am Heart Assoc	10.1161/jaha.125.041521	2025
Metabolism	Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro.	Yoo HJ, Jwa SK, Kim DH, Ji YJ.	Clin Exp Dent Res	10.1002/cre2.269	2020
Pathogenicity	Spent culture supernatant of Streptococcus gordonii mitigates inflammation of human periodontal cells and inhibits proliferation of pathogenic oral microbes.	Shu Y, Upara C, Ding Q, Zhu M, Zeng E, Banas JA, Hong L.	J Periodontol	10.1002/jper.22-0333	2023
	Differential analysis of culturable and unculturable subgingival target microorganisms according to the stages of periodontitis.	Lafaurie GI, Castillo DM, Iniesta M, Sanz M, Gomez LA, Castillo Y, Pianeta R, Delgadillo NA, Neuta Y, Diaz-Baez D, Herrera D.	Clin Oral Investig	10.1007/s00784-023-04907-5	2023
	Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts.	Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL.	Front Cell Infect Microbiol	10.3389/fcimb.2021.671968	2021
	Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting.	Radaic A, Brody H, Contreras F, Hajfathalian M, Lucido L, Kamarajan P, Kapila YL.	Microorganisms	10.3390/microorganisms10071336	2022
	Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium.	Camargo SEA, Xia X, Fares C, Ren F, Hsu SM, Budei D, Aravindraja C, Kesavalu L, Esquivel-Upshaw JF.	Materials (Basel)	10.3390/ma14164357	2021
	Presence of Specific Periodontal Pathogens in Prostate Gland Diagnosed With Chronic Inflammation and Adenocarcinoma.	Alluri LSC, Paes Batista da Silva A, Verma S, Fu P, Shen DL, MacLennan G, Gupta S, Bissada NF.	Cureus	10.7759/cureus.17742	2021
	Prevalence of target anaerobes associated with chronic periodontitis.	Alazemi AM, Jamal W, Al Khabbaz A, Rotimi VO.	Access Microbiol	10.1099/acmi.0.000177	2020
	Effects of i-PRF, A-PRF+, and EMD on Osteogenic Potential of Osteoblasts on Titanium.	Ramenzoni LL, Varghese J, Schmidlin PR, Mehrotra S.	Clin Implant Dent Relat Res	10.1111/cid.13406	2025
	Quantitative Analysis of Candidate Endodontic Pathogens and Their Association with Cause and Symptoms of Apical Periodontitis in a Sudanese Population.	Abushouk S, Lundy F, Linden G, Abdel Hamid MM, Ibrahim Y, El Karim I.	Eur Endod J	10.14744/eej.2020.52297	2021
	Small regulatory RNAs of oral streptococci and periodontal bacteria.	Oogai Y, Nakata M.	Jpn Dent Sci Rev	10.1016/j.jdsr.2021.09.004	2021
	Oral Microbiota in Children with Cleft Lip and Palate: A Systematic Review.	Switala J, Sycinska-Dziarnowska M, Spagnuolo G, Wozniak K, Mankowska K, Szyszka-Sommerfeld L.	J Clin Med	10.3390/jcm12185867	2023
Phylogeny	Passive Filtration, Rapid Scanning Electron Microscopy, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Treponema Culture and Identification from the Oral Cavity.	Belkacemi S, Bou Khalil J, Ominami Y, Hisada A, Fontanini A, Caputo A, Levasseur A, Lagier JC, Khelaifia S, Raoult D.	J Clin Microbiol	10.1128/jcm.00517-19	2019
	Differential effects of periodontal microbiome on the rheumatoid factor induction during rheumatoid arthritis pathogenesis.	Kim JW, Jung H, Baek IP, Nam Y, Kang J, Chung MK, Park JB, Lee J, Kwok SK, Kim WU, Park SH, Ju JH.	Sci Rep	10.1038/s41598-022-21788-y	2022
	The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis.	Ng HM, Slakeski N, Butler CA, Veith PD, Chen YY, Liu SW, Hoffmann B, Dashper SG, Reynolds EC.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00432	2019
	Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola.	Kin LX, Butler CA, Slakeski N, Hoffmann B, Dashper SG, Reynolds EC.	J Oral Microbiol	10.1080/20002297.2020.1808750	2020
	Serine/Glycine Lipid Recovery in Lipid Extracts From Healthy and Diseased Dental Samples: Relationship to Chronic Periodontitis.	Nichols FC, Bhuse K, Clark RB, Provatas AA, Carrington E, Wang YH, Zhu Q, Davey ME, Dewhirst FE.	Front Oral Health	10.3389/froh.2021.698481	2021
Pathogenicity	In-vitro effects of different hyaluronic acids on periodontal biofilm-immune cell interaction.	Zhu X, Sculean A, Eick S.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1414861	2024
	A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis.	Muok AR, Kurniyati K, Cassidy CK, Olsthoorn FA, Ortega DR, Mabrouk AS, Li C, Briegel A.	mBio	10.1128/mbio.01598-23	2023
Pathogenicity	Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies.	Lasica A, Golec P, Laskus A, Zalewska M, Gedaj M, Popowska M.	Front Microbiol	10.3389/fmicb.2024.1469414	2024
Metabolism	Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.	Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL.	PLoS Pathog	10.1371/journal.ppat.1009311	2021
Pathogenicity	Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.	Kamarajan P, Ateia I, Shin JM, Fenno JC, Le C, Zhan L, Chang A, Darveau R, Kapila YL.	PLoS Pathog	10.1371/journal.ppat.1008881	2020
	Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in Treponema denticola.	Saraithong P, Goetting-Minesky MP, Durbin PM, Olson SW, Gherardini FC, Fenno JC.	J Bacteriol	10.1128/jb.00770-19	2020
Enzymology	Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery.	Ye C, Xia Z, Tang J, Khemwong T, Kapila Y, Kuraji R, Huang P, Wu Y, Kobayashi H.	Sci Rep	10.1038/s41598-020-72807-9	2020
Genetics	Paleogenomic insights into the red complex bacteria Tannerella forsythia in Pre-Hispanic and Colonial individuals from Mexico.	Bravo-Lopez M, Villa-Islas V, Rocha Arriaga C, Villasenor-Altamirano AB, Guzman-Solis A, Sandoval-Velasco M, Wesp JK, Alcantara K, Lopez-Corral A, Gomez-Valdes J, Mejia E, Herrera A, Meraz-Moreno A, Moreno-Cabrera ML, Moreno-Estrada A, Nieves-Colon MA, Olvera J, Perez-Perez J, Iversen KH, Rasmussen S, Sandoval K, Zepeda G, Avila-Arcos MC.	Philos Trans R Soc Lond B Biol Sci	10.1098/rstb.2019.0580	2020
	A novel ionic liquid-based approach for DNA and RNA extraction simplifies sample preparation for bacterial diagnostics.	Kreuter J, Bica-Schroder K, Palvolgyi AM, Krska R, Sommer R, Farnleitner AH, Kolm C, Reischer GH.	Anal Bioanal Chem	10.1007/s00216-024-05615-z	2024
	Detection of Novel Integrons in the Metagenome of Human Saliva.	Tansirichaiya S, Rahman MA, Antepowicz A, Mullany P, Roberts AP.	PLoS One	10.1371/journal.pone.0157605	2016
Enzymology	Treponema denticola enolase contributes to the production of antibodies against ENO1 but not to the progression of periodontitis.	Lee A, Kim YC, Baek K, Alam J, Choi YS, Rheu Y, Shin YJ, Kim S, Kim HD, Song YW, Choi Y.	Virulence	10.1080/21505594.2018.1496775	2018
Genetics	HOPS: automated detection and authentication of pathogen DNA in archaeological remains.	Hubler R, Key FM, Warinner C, Bos KI, Krause J, Herbig A.	Genome Biol	10.1186/s13059-019-1903-0	2019
	In vitro activity of hyaluronic acid and human serum on periodontal biofilm and periodontal ligament fibroblasts.	Zhu X, von Werdt L, Zappala G, Sculean A, Eick S, Stahli A.	Clin Oral Investig	10.1007/s00784-023-05121-z	2023
	Microbiological and biochemical findings in relation to clinical periodontal status in active smokers, non-smokers and passive smokers.	Kanmaz B, Lamont G, Danaci G, Gogeneni H, Buduneli N, Scott DA.	Tob Induc Dis	10.18332/tid/104492	2019
Phylogeny	Multilocus sequence analysis of Treponema denticola strains of diverse origin.	Mo S, You M, Su YC, Lacap-Bugler DC, Huo YB, Smith GJ, Leung WK, Leung WK, Leung WK, Watt RM.	BMC Microbiol	10.1186/1471-2180-13-24	2013
	An inventory of early branch points in microbial phosphonate biosynthesis.	Li S, Horsman GP.	Microb Genom	10.1099/mgen.0.000781	2022
Phylogeny	Genome-wide relatedness of Treponema pedis, from gingiva and necrotic skin lesions of pigs, with the human oral pathogen Treponema denticola.	Svartstrom O, Mushtaq M, Pringle M, Segerman B.	PLoS One	10.1371/journal.pone.0071281	2013
Metabolism	Fibronectin-binding protein TDE1579 affects cytotoxicity of Treponema denticola.	Xu X, Steffensen B, Robichaud TK, Mikhailova M, Lai V, Montgomery R, Chu L.	Anaerobe	10.1016/j.anaerobe.2015.09.010	2015
Metabolism	Major membrane protein TDE2508 regulates adhesive potency in Treponema denticola.	Abiko Y, Nagano K, Yoshida Y, Yoshimura F.	PLoS One	10.1371/journal.pone.0089051	2014
	Diterpenoid Constituents of Psiadia punctulata and Evaluation of Their Antimicrobial Activity.	Donadio G, Chini MG, Parisi V, Mensitieri F, Malafronte N, Bifulco G, Bisio A, De Tommasi N, Bader A.	J Nat Prod	10.1021/acs.jnatprod.1c01093	2022
Pathogenicity	Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2.	Ruby J, Martin M, Passineau MJ, Godovikova V, Fenno JC, Wu H.	Infect Immun	10.1128/iai.00573-17	2018
	The In-Vitro Activity of a Cold Atmospheric Plasma Device Utilizing Ambient Air against Bacteria and Biofilms Associated with Periodontal or Peri-Implant Diseases.	Jungbauer G, Favaro L, Muller S, Sculean A, Eick S.	Antibiotics (Basel)	10.3390/antibiotics11060752	2022
	Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox.	Jeyakumar J, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.a45437	2020
Metabolism	Studying bacterial chemosensory array with CryoEM.	Qin Z, Zhang P.	Biochem Soc Trans	10.1042/bst20210080	2021
	A pleiotropic role of FlaG in regulating the cell morphogenesis and flagellar homeostasis at the cell poles of Treponema denticola.	Kurniyati K, Liu J, Zhang JR, Min Y, Li C.	Cell Microbiol	10.1111/cmi.12886	2019
	Metagenomic analysis reveals presence of Treponema denticola in a tissue biopsy of the Iceman.	Maixner F, Thomma A, Cipollini G, Widder S, Rattei T, Zink A.	PLoS One	10.1371/journal.pone.0099994	2014
	Three-Dimensional In Vitro Oral Mucosa Models of Fungal and Bacterial Infections.	Tabatabaei F, Moharamzadeh K, Tayebi L.	Tissue Eng Part B Rev	10.1089/ten.teb.2020.0016	2020
	Specific Oral Microbial Differences in Proteobacteria and Bacteroidetes Are Associated with Distinct Sites When Moving from Healthy Mucosa to Oral Dysplasia-A Microbiome and Gene Profiling Study and Focused Review.	Radaic A, Shamir ER, Jones K, Villa A, Garud NR, Tward AD, Kamarajan P, Kapila YL.	Microorganisms	10.3390/microorganisms11092250	2023
	Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis.	Papantonopoulos G, Delatola C, Takahashi K, Laine ML, Loos BG.	PLoS One	10.1371/journal.pone.0224615	2019
Genetics	Exploring neighborhoods in large metagenome assembly graphs using spacegraphcats reveals hidden sequence diversity.	Brown CT, Moritz D, O'Brien MP, Reidl F, Reiter T, Sullivan BD.	Genome Biol	10.1186/s13059-020-02066-4	2020
Metabolism	The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola.	Puthenveetil R, Kumar S, Caimano MJ, Dey A, Anand A, Vinogradova O, Radolf JD.	Sci Rep	10.1038/s41598-017-13550-6	2017
	The central region of the msp gene of Treponema denticola has sequence heterogeneity among clinical samples, obtained from patients with periodontitis.	Gaibani P, Pellegrino MT, Rossini G, Alvisi G, Miragliotta L, Prati C, Sambri V.	BMC Infect Dis	10.1186/1471-2334-10-345	2010
Metabolism	Atypical chemoreceptor arrays accommodate high membrane curvature.	Muok AR, Ortega DR, Kurniyati K, Yang W, Maschmann ZA, Sidi Mabrouk A, Li C, Crane BR, Briegel A.	Nat Commun	10.1038/s41467-020-19628-6	2020
	pyrF as a Counterselectable Marker for Unmarked Genetic Manipulations in Treponema denticola.	Kurniyati K, Li C.	Appl Environ Microbiol	10.1128/aem.03704-15	2016
	In Vitro Activity of Propolis on Oral Microorganisms and Biofilms.	Stahli A, Schroter H, Bullitta S, Serralutzu F, Dore A, Nietzsche S, Milia E, Sculean A, Eick S.	Antibiotics (Basel)	10.3390/antibiotics10091045	2021
Metabolism	Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities.	Cogoni V, Morgan-Smith A, Fenno JC, Jenkinson HF, Dymock D.	Microbiology (Reading)	10.1099/mic.0.055939-0	2012
	Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.	Kuraji R, Ye C, Zhao C, Gao L, Martinez A, Miyashita Y, Radaic A, Kamarajan P, Le C, Zhan L, Range H, Sunohara M, Numabe Y, Kapila YL.	NPJ Biofilms Microbiomes	10.1038/s41522-024-00476-x	2024
	Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo.	Cecil JD, O'Brien-Simpson NM, Lenzo JC, Holden JA, Singleton W, Perez-Gonzalez A, Mansell A, Reynolds EC.	Front Immunol	10.3389/fimmu.2017.01017	2017
	A simplified erythromycin resistance cassette for Treponema denticola mutagenesis.	Goetting-Minesky MP, Fenno JC.	J Microbiol Methods	10.1016/j.mimet.2010.07.020	2010
Metabolism	Characterization of a novel family of fibronectin-binding proteins with M23 peptidase domains from Treponema denticola.	Bamford CV, Francescutti T, Cameron CE, Jenkinson HF, Dymock D.	Mol Oral Microbiol	10.1111/j.2041-1014.2010.00584.x	2010
Transcriptome	Worlds Apart - Transcriptome Profiles of Key Oral Microbes in the Periodontal Pocket Compared to Single Laboratory Culture Reflect Synergistic Interactions.	Deng ZL, Sztajer H, Jarek M, Bhuju S, Wagner-Dobler I.	Front Microbiol	10.3389/fmicb.2018.00124	2018
Metabolism	Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola.	Ishihara K, Wawrzonek K, Shaw LN, Inagaki S, Miyamoto M, Potempa J.	Biol Chem	10.1515/bc.2010.113	2010
Phylogeny	Polymicrobial periodontal disease triggers a wide radius of effect and unique virome.	Gao L, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Range H, Ho SP, Kapila YL.	NPJ Biofilms Microbiomes	10.1038/s41522-020-0120-7	2020
Metabolism	Evidence that TP_0144 of Treponema pallidum is a thiamine-binding protein.	Bian J, Tu Y, Wang SM, Wang XY, Li C.	J Bacteriol	10.1128/jb.02472-14	2015
Metabolism	Composition and localization of Treponema denticola outer membrane complexes.	Godovikova V, Goetting-Minesky MP, Fenno JC.	Infect Immun	10.1128/iai.05701-11	2011
Metabolism	Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola.	Bian J, Liu X, Cheng YQ, Li C.	J Bacteriol	10.1128/jb.00610-13	2013
	Discovery of Lacto-N-Biosidases and a Novel N-Acetyllactosaminidase Activity in the CAZy Family GH20: Functional Diversity and Structural Insights.	Vuillemin M, Muschiol J, Zhang Y, Holck J, Barrett K, Preben Morth J, Meyer AS, Zeuner B.	Chembiochem	10.1002/cbic.202400710	2025
Metabolism	1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.	Vences-Guzman MA, Paula Goetting-Minesky M, Guan Z, Castillo-Ramirez S, Cordoba-Castro LA, Lopez-Lara IM, Geiger O, Sohlenkamp C, Christopher Fenno J.	Mol Microbiol	10.1111/mmi.13596	2017
	Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development.	Zhu Y, Dashper SG, Chen YY, Crawford S, Slakeski N, Reynolds EC.	PLoS One	10.1371/journal.pone.0071727	2013
Pathogenicity	Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens.	Gu Z, Singh S, Niyogi RG, Lamont GJ, Wang H, Lamont RJ, Scott DA.	Front Immunol	10.3389/fimmu.2019.02288	2019
	Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.	Marttila E, Jarvensivu A, Sorsa T, Grenier D, Richardson M, Richardson M, Kari K, Tervahartiala T, Rautemaa R.	J Oral Microbiol	10.3402/jom.v6.24349	2014
Enzymology	Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications.	Ateia IM, Sutthiboonyapan P, Kamarajan P, Jin T, Godovikova V, Kapila YL, Fenno JC.	Cell Microbiol	10.1111/cmi.12815	2018
Genetics	Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease.	Endo A, Watanabe T, Ogata N, Nozawa T, Aikawa C, Arakawa S, Maruyama F, Izumi Y, Nakagawa I.	ISME J	10.1038/ismej.2014.155	2015
	Metabolic engineering of Escherichia coli for the production of butyric acid at high titer and productivity.	Wang L, Chauliac D, Moritz BE, Zhang G, Ingram LO, Shanmugam KT.	Biotechnol Biofuels	10.1186/s13068-019-1408-9	2019
	Characterization of Treponema denticola mutants defective in the major antigenic proteins, Msp and TmpC.	Abiko Y, Nagano K, Yoshida Y, Yoshimura F.	PLoS One	10.1371/journal.pone.0113565	2014
Transcriptome	Gene expression of bacterial collagenolytic proteases in root caries.	Dame-Teixeira N, Parolo CCF, Maltz M, Rup AG, Devine DA, Do T.	J Oral Microbiol	10.1080/20002297.2018.1424475	2018
	Binding properties of Treponema denticola lipooligosaccharide.	Grenier D.	J Oral Microbiol	10.3402/jom.v5i0.21517	2013
	Porphyromonas gingivalis Outer Membrane Vesicles Mediate Coaggregation and Piggybacking of Treponema denticola and Lachnoanaerobaculum saburreum.	Grenier D.	Int J Dent	10.1155/2013/305476	2013
	Increased infection with key periodontal pathogens during gestational diabetes mellitus.	Gogeneni H, Buduneli N, Ceyhan-Ozturk B, Gumus P, Akcali A, Zeller I, Renaud DE, Scott DA, Ozcaka O.	J Clin Periodontol	10.1111/jcpe.12418	2015
	Mixed red-complex bacterial infection in periodontitis.	Suzuki N, Yoneda M, Hirofuji T.	Int J Dent	10.1155/2013/587279	2013
	Development of a modified gentamicin resistance cassette for genetic manipulation of the oral spirochete Treponema denticola.	Bian J, Fenno JC, Li C.	Appl Environ Microbiol	10.1128/aem.07461-11	2012
	Putative periodontopathic bacteria and herpes viruses interactions in the subgingival plaque of patients with aggressive periodontitis and healthy controls.	Elamin A, Ali RW, Bakken V.	Clin Exp Dent Res	10.1002/cre2.80	2017
Genetics	The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.	Jaiswal AK, Tiwari S, Jamal SB, de Castro Oliveira L, Alves LG, Azevedo V, Ghosh P, Oliveira CJF, Soares SC.	BMC Genomics	10.1186/s12864-019-6430-6	2020
	The gain and loss of chromosomal integron systems in the Treponema species.	Wu YW, Doak TG, Ye Y.	BMC Evol Biol	10.1186/1471-2148-13-16	2013
Metabolism	Extracellular RNAs in Bacterial Infections: From Emerging Key Players on Host-Pathogen Interactions to Exploitable Biomarkers and Therapeutic Targets.	Pita T, Feliciano JR, Leitao JH.	Int J Mol Sci	10.3390/ijms21249634	2020
Metabolism	The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha.	Miyamoto M, Ishihara K, Okuda K.	Infect Immun	10.1128/iai.74.4.2462-2467.2006	2006
Phylogeny	Biochemical and molecular characterization of Treponema phagedenis-like spirochetes isolated from a bovine digital dermatitis lesion.	Wilson-Welder JH, Elliott MK, Zuerner RL, Bayles DO, Alt DP, Stanton TB.	BMC Microbiol	10.1186/1471-2180-13-280	2013
Genetics	Draft genome sequence of 'Treponema phagedenis' strain V1, isolated from bovine digital dermatitis.	Mushtaq M, Manzoor S, Pringle M, Rosander A, Bongcam-Rudloff E.	Stand Genomic Sci	10.1186/s40793-015-0059-0	2015
Enzymology	Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection.	Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC.	Arch Oral Biol	10.1016/j.archoralbio.2014.06.003	2014
	Is there a relationship between spondyloarthritis and periodontitis? A case-control study.	Bautista-Molano W, van der Heijde D, Landewe R, Lafaurie GI, de Avila J, Valle-Onate R, Romero-Sanchez C.	RMD Open	10.1136/rmdopen-2017-000547	2017
Enzymology	Optimization of quantitative polymerase chain reactions for detection and quantification of eight periodontal bacterial pathogens.	Decat E, Cosyn J, De Bruyn H, Miremadi R, Saerens B, Van Mechelen E, Vermeulen S, Vaneechoutte M, Deschaght P.	BMC Res Notes	10.1186/1756-0500-5-664	2012
Metabolism	Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses.	Tan KH, Seers CA, Dashper SG, Mitchell HL, Pyke JS, Meuric V, Slakeski N, Cleal SM, Chambers JL, McConville MJ, Reynolds EC.	PLoS Pathog	10.1371/journal.ppat.1003955	2014
Metabolism	Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation.	Bao K, Belibasakis GN, Thurnheer T, Aduse-Opoku J, Curtis MA, Bostanci N.	BMC Microbiol	10.1186/s12866-014-0258-7	2014
	Humoral immune responses to periodontal pathogens in the elderly.	Shet U, Oh HK, Chung HJ, Kim YJ, Kim OS, Lim HJ, Shin MH, Lee SW.	J Periodontal Implant Sci	10.5051/jpis.2015.45.5.178	2015
	Development of a transposon mutagenesis system in the oral spirochete Treponema denticola.	Yang Y, Stewart PE, Shi X, Li C.	Appl Environ Microbiol	10.1128/aem.01424-08	2008
Metabolism	Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook.	Lynch MJ, Miller M, James M, Zhang S, Zhang K, Li C, Charon NW, Crane BR.	Nat Chem Biol	10.1038/s41589-019-0341-3	2019
	Molecular signaling mechanisms of the periopathogen, Treponema denticola.	Frederick JR, Sarkar J, McDowell JV, Marconi RT.	J Dent Res	10.1177/0022034511402994	2011
Metabolism	Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.	McDowell JV, Lankford J, Stamm L, Sadlon T, Gordon DL, Marconi RT.	Infect Immun	10.1128/iai.73.11.7126-7132.2005	2005
Metabolism	Impact of aging on TREM-1 responses in the periodontium: a cross-sectional study in an elderly population.	Ozturk VO, Belibasakis GN, Emingil G, Bostanci N.	BMC Infect Dis	10.1186/s12879-016-1778-6	2016
Pathogenicity	Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis.	Visser MB, Sun CX, Koh A, Ellen RP, Glogauer M.	PLoS One	10.1371/journal.pone.0066209	2013
	Transcriptional responses of Treponema denticola to other oral bacterial species.	Sarkar J, McHardy IH, Simanian EJ, Shi W, Lux R.	PLoS One	10.1371/journal.pone.0088361	2014
Metabolism	A novel glycan modifies the flagellar filament proteins of the oral bacterium Treponema denticola.	Kurniyati K, Kelly JF, Vinogradov E, Robotham A, Tu Y, Wang J, Liu J, Logan SM, Li C.	Mol Microbiol	10.1111/mmi.13544	2017
Metabolism	A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola.	Kurniyati K, Zhang W, Zhang K, Li C.	Mol Microbiol	10.1111/mmi.12311	2013
Metabolism	Conservation of the Host-Interacting Proteins Tp0750 and Pallilysin among Treponemes and Restriction of Proteolytic Capacity to Treponema pallidum.	Houston S, Taylor JS, Denchev Y, Hof R, Zuerner RL, Cameron CE.	Infect Immun	10.1128/iai.00643-15	2015
	Impact of early colonizers on in vitro subgingival biofilm formation.	Ammann TW, Belibasakis GN, Thurnheer T.	PLoS One	10.1371/journal.pone.0083090	2013
Metabolism	Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex.	Godovikova V, Wang HT, Goetting-Minesky MP, Ning Y, Capone RF, Slater CK, Fenno JC.	J Bacteriol	10.1128/jb.00274-10	2010
Pathogenicity	Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola.	Brissette CA, Lukehart SA.	Infect Immun	10.1128/iai.01718-06	2007
Enzymology	Loop-mediated isothermal amplification method for rapid detection of the periodontopathic bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola.	Yoshida A, Nagashima S, Ansai T, Tachibana M, Kato H, Watari H, Notomi T, Takehara T.	J Clin Microbiol	10.1128/jcm.43.5.2418-2424.2005	2005
Metabolism	Dioxygen and nitric oxide scavenging by Treponema denticola flavodiiron protein: a mechanistic paradigm for catalysis.	Frederick RE, Caranto JD, Masitas CA, Gebhardt LL, MacGowan CE, Limberger RJ, Kurtz DM.	J Biol Inorg Chem	10.1007/s00775-015-1248-4	2015
	Integrated biomarker profiling of smokers with periodontitis.	Nagarajan R, Al-Sabbagh M, Dawson D, Ebersole JL.	J Clin Periodontol	10.1111/jcpe.12659	2017
Metabolism	Treponema denticola alters cell vitality and induces HO-1 and Hsp70 expression in porcine aortic endothelial cells.	Bernardini C, Gaibani P, Zannoni A, Vocale C, Bacci ML, Piana G, Forni M, Sambri V.	Cell Stress Chaperones	10.1007/s12192-009-0164-3	2010
Metabolism	The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells.	Miao D, Fenno JC, Timm JC, Joo NE, Kapila YL.	Infect Immun	10.1128/iai.01001-10	2011
Metabolism	The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers.	Anand A, Luthra A, Edmond ME, Ledoyt M, Caimano MJ, Radolf JD.	J Bacteriol	10.1128/jb.00078-13	2013
Metabolism	Behavior of two Tannerella forsythia strains and their cell surface mutants in multispecies oral biofilms.	Bloch S, Thurnheer T, Murakami Y, Belibasakis GN, Schaffer C.	Mol Oral Microbiol	10.1111/omi.12182	2017
	Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components.	Nussbaum G, Ben-Adi S, Genzler T, Sela M, Rosen G.	Infect Immun	10.1128/iai.00488-09	2009
Pathogenicity	The oralome and its dysbiosis: New insights into oral microbiome-host interactions.	Radaic A, Kapila YL.	Comput Struct Biotechnol J	10.1016/j.csbj.2021.02.010	2021
	Quantitative analysis of periodontal pathogens present in the saliva of geriatric subjects.	Shet UK, Oh HK, Kim HJ, Chung HJ, Kim YJ, Kim OS, Choi HR, Kim OJ, Lim HJ, Lee SW.	J Periodontal Implant Sci	10.5051/jpis.2013.43.4.183	2013
	A Biofilm Pocket Model to Evaluate Different Non-Surgical Periodontal Treatment Modalities in Terms of Biofilm Removal and Reformation, Surface Alterations and Attachment of Periodontal Ligament Fibroblasts.	Hagi TT, Klemensberger S, Bereiter R, Nietzsche S, Cosgarea R, Flury S, Lussi A, Sculean A, Eick S.	PLoS One	10.1371/journal.pone.0131056	2015
	Teth137, a Conserved Factor of Unknown Function from Thermoanaerobacter ethanolicus JW200, Represses the Transcription of the adhE Gene In Vitro.	Jing Q, Wang J, Wu G.	Indian J Microbiol	10.1007/s12088-012-0339-y	2013
Metabolism	Treponema denticola superoxide reductase: in vivo role, in vitro reactivities, and a novel [Fe(Cys)(4)] site.	Caranto JD, Gebhardt LL, MacGowan CE, Limberger RJ, Kurtz DM.	Biochemistry	10.1021/bi300667s	2012
Metabolism	The antibacterial activity of LL-37 against Treponema denticola is dentilisin protease independent and facilitated by the major outer sheath protein virulence factor.	Rosen G, Sela MN, Bachrach G.	Infect Immun	10.1128/iai.05903-11	2012
Metabolism	Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor.	Brett PJ, Burtnick MN, Fenno JC, Gherardini FC.	Mol Microbiol	10.1111/j.1365-2958.2008.06418.x	2008
Metabolism	Spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility.	Miller MR, Miller KA, Bian J, James ME, Zhang S, Lynch MJ, Callery PS, Hettick JM, Cockburn A, Liu J, Li C, Crane BR, Charon NW.	Nat Microbiol	10.1038/nmicrobiol.2016.134	2016
	Immune response and alveolar bone resorption in a mouse model of Treponema denticola infection.	Lee SF, Andrian E, Rowland E, Marquez IC.	Infect Immun	10.1128/iai.01004-08	2009
Pathogenicity	Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein.	Puthengady Thomas B, Sun CX, Bajenova E, Ellen RP, Glogauer M.	Infect Immun	10.1128/iai.74.3.1954-1957.2006	2006
Enzymology	The opdB locus encodes the trypsin-like peptidase activity of Treponema denticola.	Fenno JC, Lee SY, Bayer CH, Ning Y.	Infect Immun	10.1128/iai.69.10.6193-6200.2001	2001
	Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults.	Collins JR, Arredondo A, Roa A, Valdez Y, Leon R, Blanc V.	Clin Oral Investig	10.1007/s00784-015-1516-2	2016
	A computational method to predict genetically encoded rare amino acids in proteins.	Chaudhuri BN, Yeates TO.	Genome Biol	10.1186/gb-2005-6-9-r79	2005
Pathogenicity	Treponema denticola is resistant to human beta-defensins.	Brissette CA, Lukehart SA.	Infect Immun	10.1128/iai.70.7.3982-3984.2002	2002
Metabolism	The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola.	Bian J, Shen H, Tu Y, Yu A, Li C.	J Bacteriol	10.1128/jb.00386-11	2011
Pathogenicity	Smoking-related cotinine levels and host responses in chronic periodontitis.	Ebersole JL, Steffen MJ, Thomas MV, Al-Sabbagh M.	J Periodontal Res	10.1111/jre.12146	2014
Enzymology	Construction and characterization of a cheA mutant of Treponema denticola.	Lux R, Sim JH, Tsai JP, Shi W.	J Bacteriol	10.1128/jb.184.11.3130-3134.2002	2002
	Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells.	Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, Kapila YL.	Front Microbiol	10.3389/fmicb.2015.00617	2015
	Identification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola.	McDowell JV, Frederick J, Miller DP, Goetting-Minesky MP, Goodman H, Fenno JC, Marconi RT.	Mol Oral Microbiol	10.1111/j.2041-1014.2010.00598.x	2011
Proteome	Proteomic shifts in multi-species oral biofilms caused by Anaeroglobus geminatus.	Bao K, Bostanci N, Thurnheer T, Belibasakis GN.	Sci Rep	10.1038/s41598-017-04594-9	2017
Metabolism	Dentilisin activity affects the organization of the outer sheath of Treponema denticola.	Ishihara K, Kuramitsu HK, Miura T, Okuda K.	J Bacteriol	10.1128/jb.180.15.3837-3844.1998	1998
Phylogeny	Targeting the treponemal microbiome of digital dermatitis infections by high-resolution phylogenetic analyses and comparison with fluorescent in situ hybridization.	Klitgaard K, Foix Breto A, Boye M, Jensen TK.	J Clin Microbiol	10.1128/jcm.00320-13	2013
Pathogenicity	Oxantel disrupts polymicrobial biofilm development of periodontal pathogens.	Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, Walsh K, D'Cruze T, Hoffmann B, Catmull D, Zhu Y, Reynolds E.	Antimicrob Agents Chemother	10.1128/aac.01375-13	2014
Metabolism	Treponema denticola major outer sheath protein induces actin assembly at free barbed ends by a PIP2-dependent uncapping mechanism in fibroblasts.	Visser MB, Koh A, Glogauer M, Ellen RP.	PLoS One	10.1371/journal.pone.0023736	2011
	Comparative analysis of oral treponemes associated with periodontal health and disease.	You M, Mo S, Leung WK, Watt RM.	BMC Infect Dis	10.1186/1471-2334-13-174	2013
	Treponema denticola in disseminating endodontic infections.	Foschi F, Izard J, Sasaki H, Sambri V, Prati C, Muller R, Stashenko P.	J Dent Res	10.1177/154405910608500814	2006
	Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease.	Sparks Stein P, Steffen MJ, Smith C, Jicha G, Ebersole JL, Abner E, Dawson D.	Alzheimers Dement	10.1016/j.jalz.2011.04.006	2012
Enzymology	Treponema denticola activates mitogen-activated protein kinase signal pathways through Toll-like receptor 2.	Ruby J, Rehani K, Martin M.	Infect Immun	10.1128/iai.01117-07	2007
	Characterization of aid1, a novel gene involved in Fusobacterium nucleatum interspecies interactions.	Kaplan A, Kaplan CW, He X, McHardy I, Shi W, Lux R.	Microb Ecol	10.1007/s00248-014-0400-y	2014
	Transcriptional profiles of Treponema denticola in response to environmental conditions.	McHardy I, Keegan C, Sim JH, Shi W, Lux R.	PLoS One	10.1371/journal.pone.0013655	2010
	Modulation of pathogenic oral biofilms towards health with nisin probiotic.	Radaic A, Ye C, Parks B, Gao L, Kuraji R, Malone E, Kamarajan P, Zhan L, Kapila YL.	J Oral Microbiol	10.1080/20002297.2020.1809302	2020
	In Vitro-Activity of Er:YAG Laser in Comparison with other Treatment Modalities on Biofilm Ablation from Implant and Tooth Surfaces.	Eick S, Meier I, Spoerle F, Bender P, Aoki A, Izumi Y, Salvi GE, Sculean A.	PLoS One	10.1371/journal.pone.0171086	2017
	Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses.	Akcali A, Bostanci N, Ozcaka O, Ozturk-Ceyhan B, Gumus P, Buduneli N, Belibasakis GN.	PLoS One	10.1371/journal.pone.0108074	2014
Metabolism	A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.	Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.	J Biol Chem	10.1074/jbc.m801034200	2008
Metabolism	Lyme disease spirochaete Borrelia burgdorferi does not require thiamin.	Zhang K, Bian J, Deng Y, Smith A, Nunez RE, Li MB, Pal U, Yu AM, Qiu W, Ealick SE, Li C.	Nat Microbiol	10.1038/nmicrobiol.2016.213	2016
	Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.	Mesa F, Lanza E, Garcia L, Marfil-Alvarez R, Magan-Fernandez A.	PLoS One	10.1371/journal.pone.0186366	2017
Metabolism	The Fusobacterium nucleatum outer membrane protein RadD is an arginine-inhibitable adhesin required for inter-species adherence and the structured architecture of multispecies biofilm.	Kaplan CW, Lux R, Haake SK, Shi W.	Mol Microbiol	10.1111/j.1365-2958.2008.06503.x	2009
Pathogenicity	In vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts.	Eick S, Strugar T, Miron RJ, Sculean A.	BMC Oral Health	10.1186/1472-6831-14-9	2014
	Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.	Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS.	J Med Chem	10.1021/acs.jmedchem.1c02045	2022
Metabolism	Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola.	Lai Y, Chu L.	Appl Environ Microbiol	10.1128/aem.01972-07	2008
Metabolism	Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression.	Chu L, Dong Z, Xu X, Cochran DL, Ebersole JL.	Infect Immun	10.1128/iai.70.3.1113-1120.2002	2002
	Antagonistic effect of oral bacteria towards Treponema denticola.	Grenier D.	J Clin Microbiol	10.1128/jcm.34.5.1249-1252.1996	1996
	Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study.	Ebersole JL, Novak MJ, Michalowicz BS, Hodges JS, Steffen MJ, Ferguson JE, Diangelis A, Buchanan W, Mitchell DA, Papapanou PN.	J Periodontol	10.1902/jop.2009.080464	2009
Metabolism	Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein.	Amin M, Ho AC, Lin JY, Batista da Silva AP, Glogauer M, Ellen RP.	Infect Immun	10.1128/iai.72.6.3650-3654.2004	2004
Metabolism	Role for recombinant gamma-glutamyltransferase from Treponema denticola in glutathione metabolism.	Chu L, Xu X, Dong Z, Cappelli D, Ebersole JL.	Infect Immun	10.1128/iai.71.1.335-342.2003	2003
	Virulence factors of the oral spirochete Treponema denticola.	Dashper SG, Seers CA, Tan KH, Reynolds EC.	J Dent Res	10.1177/0022034510385242	2011
	Complementation of a Treponema denticola flgE mutant with a novel coumermycin A1-resistant T. denticola shuttle vector system.	Chi B, Limberger RJ, Kuramitsu HK.	Infect Immun	10.1128/iai.70.4.2233-2237.2002	2002
Metabolism	The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis.	Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP.	Nat Commun	10.1038/s41467-019-11627-6	2019
	Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome.	Gao L, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Range H, Sailani MR, Kapila YL.	NPJ Biofilms Microbiomes	10.1038/s41522-022-00307-x	2022
Enzymology	Cleavage of Treponema denticola PrcA polypeptide to yield protease complex-associated proteins Prca1 and Prca2 is dependent on PrtP.	Lee SY, Bian XL, Wong GW, Hannam PM, McBride BC, Fenno JC.	J Bacteriol	10.1128/jb.184.14.3864-3870.2002	2002
	Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola.	Egli C, Leung WK, Leung WK, Muller KH, Hancock RE, McBride BC.	Infect Immun	10.1128/iai.61.5.1694-1699.1993	1993
Phylogeny	Comparative genomics of the transportome of Ten Treponema species.	Buyuktimkin B, Zafar H, Saier MH.	Microb Pathog	10.1016/j.micpath.2019.04.034	2019
Enzymology	Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitis.	Kaman WE, Galassi F, de Soet JJ, Bizzarro S, Loos BG, Veerman EC, van Belkum A, Hays JP, Bikker FJ.	J Clin Microbiol	10.1128/jcm.05313-11	2012
Metabolism	Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells.	Nokhbehsaim M, Eick S, Nogueira AV, Hoffmann P, Herms S, Frohlich H, Jepsen S, Jager A, Cirelli JA, Deschner J.	Mediators Inflamm	10.1155/2013/437123	2013
Metabolism	Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease.	Anders C, Niewoehner O, Duerst A, Jinek M.	Nature	10.1038/nature13579	2014
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Metabolism	Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.	Wang J, Qi J, Zhao H, He S, Zhang Y, Wei S, Zhao F.	Sci Rep	10.1038/srep01843	2013
Enzymology	Population-based study of salivary carriage of periodontal pathogens in adults.	Kononen E, Paju S, Pussinen PJ, Hyvonen M, Di Tella P, Suominen-Taipale L, Knuuttila M.	J Clin Microbiol	10.1128/jcm.02560-06	2007
	Oral spirochetes implicated in dental diseases are widespread in normal human subjects and carry extremely diverse integron gene cassettes.	Wu YW, Rho M, Doak TG, Ye Y.	Appl Environ Microbiol	10.1128/aem.00564-12	2012
	Optimizing qPCR for the Quantification of Periodontal Pathogens in a Complex Plaque Biofilm.	Kirakodu SS, Govindaswami M, Novak MJ, Ebersole JL, Novak KF.	Open Dent J	10.2174/1874210600802010049	2008
Phylogeny	16S rRNA amplicon sequencing reveals a polymicrobial nature of complicated claw horn disruption lesions and interdigital phlegmon in dairy cattle.	Bay V, Griffiths B, Carter S, Evans NJ, Lenzi L, Bicalho RC, Oikonomou G.	Sci Rep	10.1038/s41598-018-33993-9	2018
Pathogenicity	Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola.	Roberts MC, Chung WO, Roe DE.	Antimicrob Agents Chemother	10.1128/aac.40.7.1690	1996
	A variable gene in a conserved region of the Helicobacter pylori genome: isotopic gene replacement or rapid evolution?	Menard A, Danchin A, Dupouy S, Megraud F, Lehours P.	DNA Res	10.1093/dnares/dsn006	2008
Enzymology	A major antigen on the outer envelope of a human oral spirochete, Treponema denticola.	Umemoto T, Namikawa I, Suido H, Asai S.	Infect Immun	10.1128/iai.57.8.2470-2474.1989	1989
	Cloning and expression of two novel hemin binding protein genes from Treponema denticola.	Xu X, Holt SC, Kolodrubetz D.	Infect Immun	10.1128/iai.69.7.4465-4472.2001	2001
Enzymology	Use of the genomic subtractive hybridization technique to develop a real-time PCR assay for quantitative detection of Prevotella spp. in oral biofilm samples.	Nagashima S, Yoshida A, Suzuki N, Ansai T, Takehara T.	J Clin Microbiol	10.1128/jcm.43.6.2948-2951.2005	2005
	Genomes of the most dangerous epidemic bacteria have a virulence repertoire characterized by fewer genes but more toxin-antitoxin modules.	Georgiades K, Raoult D.	PLoS One	10.1371/journal.pone.0017962	2011
Genetics	Comparative genomics evidence that only protein toxins are tagging bad bugs.	Georgiades K, Raoult D.	Front Cell Infect Microbiol	10.3389/fcimb.2011.00007	2011
Pathogenicity	Cross-talk between clinical and host-response parameters of periodontitis in smokers.	Nagarajan R, Miller CS, Dawson D, Al-Sabbagh M, Ebersole JL.	J Periodontal Res	10.1111/jre.12397	2017
	An in vitro biofilm model of subgingival plaque.	Walker C, Sedlacek MJ.	Oral Microbiol Immunol	10.1111/j.1399-302x.2007.00336.x	2007
Genetics	The bioinformatics resource for oral pathogens.	Chen T, Abbey K, Deng WJ, Cheng MC.	Nucleic Acids Res	10.1093/nar/gki361	2005
Metabolism	A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.	Coumes-Florens S, Brochier-Armanet C, Guiseppi A, Denizot F, Foglino M.	PLoS One	10.1371/journal.pone.0015951	2011
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	Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine.	Hawley KL, Montezuma-Rusca JM, Delgado KN, Singh N, Uversky VN, Caimano MJ, Radolf JD, Luthra A.	J Bacteriol	10.1128/jb.00082-21	2021
Enzymology	Proteases of Treponema denticola outer sheath and extracellular vesicles.	Rosen G, Naor R, Rahamim E, Yishai R, Sela MN.	Infect Immun	10.1128/iai.63.10.3973-3979.1995	1995
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Phylogeny	Identification of seven Treponema species in health- and disease-associated dental plaque by nested PCR.	Willis SG, Smith KS, Dunn VL, Gapter LA, Riviere KH, Riviere GR.	J Clin Microbiol	10.1128/jcm.37.3.867-869.1999	1999
Pathogenicity	Beneficial effects of adiponectin on periodontal ligament cells under normal and regenerative conditions.	Nokhbehsaim M, Keser S, Nogueira AV, Cirelli JA, Jepsen S, Jager A, Eick S, Deschner J.	J Diabetes Res	10.1155/2014/796565	2014
	Cytopathic effects of the major surface protein and the chymotrypsinlike protease of Treponema denticola.	Fenno JC, Hannam PM, Leung WK, Leung WK, Tamura M, Uitto VJ, McBride BC.	Infect Immun	10.1128/iai.66.5.1869-1877.1998	1998
	Quantitative and qualitative analysis of microorganisms in root-filled teeth with persistent infection: Monitoring of the endodontic retreatment.	Endo MS, Ferraz CCR, Zaia AA, Almeida JFA, Gomes BPFA.	Eur J Dent	10.4103/1305-7456.115414	2013
Metabolism	Activation of the interleukin-1beta precursor by Treponema denticola: a potential role in chronic inflammatory periodontal diseases.	Beausejour A, Deslauriers N, Grenier D.	Infect Immun	10.1128/iai.65.8.3199-3202.1997	1997
Enzymology	Development of a 5' fluorogenic nuclease-based real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.	Yoshida A, Suzuki N, Nakano Y, Oho T, Kawada M, Koga T.	J Clin Microbiol	10.1128/jcm.41.2.863-866.2003	2003
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Metabolism	Degradation of endogenous plasma membrane fibronectin concomitant with Treponema denticola 35405 adhesion to gingival fibroblasts.	Ellen RP, Song M, McCulloch CA.	Infect Immun	10.1128/iai.62.7.3033-3037.1994	1994
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Enzymology	Cloning and expression of the aspartate carbamoyltransferase gene from Treponema denticola.	Ishihara K, Ishihara M, Takazoe I, Okuda K.	Appl Environ Microbiol	10.1128/aem.58.10.3399-3403.1992	1992
Enzymology	Characterization of fibrinolytic activities of Treponema denticola.	Rosen G, Naor R, Kutner S, Sela MN.	Infect Immun	10.1128/iai.62.5.1749-1754.1994	1994
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Enzymology	Characterization, distribution, and expression of novel genes among eight clinical isolates of Streptococcus pneumoniae.	Shen K, Gladitz J, Antalis P, Dice B, Janto B, Keefe R, Hayes J, Ahmed A, Dopico R, Ehrlich N, Jocz J, Kropp L, Yu S, Nistico L, Greenberg DP, Barbadora K, Preston RA, Post JC, Ehrlich GD, Hu FZ.	Infect Immun	10.1128/iai.74.1.321-330.2006	2006
Enzymology	Molecular evolution of urea amidolyase and urea carboxylase in fungi.	Strope PK, Nickerson KW, Harris SD, Moriyama EN.	BMC Evol Biol	10.1186/1471-2148-11-80	2011
Pathogenicity	Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells.	Uitto VJ, Pan YM, Leung WK, Leung WK, Larjava H, Ellen RP, Finlay BB, McBride BC.	Infect Immun	10.1128/iai.63.9.3401-3410.1995	1995
Enzymology	Cellular location of a Treponema denticola chymotrypsinlike protease and importance of the protease in migration through the basement membrane.	Grenier D, Uitto VJ, McBride BC.	Infect Immun	10.1128/iai.58.2.347-351.1990	1990
	Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.	Dhaliwal JS, Abd Rahman NA, Ming LC, Dhaliwal SKS, Knights J, Albuquerque Junior RF.	Front Cell Infect Microbiol	10.3389/fcimb.2021.736186	2021
	Leptin effects on the regenerative capacity of human periodontal cells.	Nokhbehsaim M, Keser S, Nogueira AV, Jager A, Jepsen S, Cirelli JA, Bourauel C, Eick S, Deschner J.	Int J Endocrinol	10.1155/2014/180304	2014
Enzymology	Development of a 5' nuclease-based real-time PCR assay for quantitative detection of cariogenic dental pathogens Streptococcus mutans and Streptococcus sobrinus.	Yoshida A, Suzuki N, Nakano Y, Kawada M, Oho T, Koga T.	J Clin Microbiol	10.1128/jcm.41.9.4438-4441.2003	2003
	Comparative in silico analysis of ftsZ gene from different bacteria reveals the preference for core set of codons in coding sequence structuring and secondary structural elements determination.	Pal A, Saha BK, Saha J.	PLoS One	10.1371/journal.pone.0219231	2019
Phylogeny	Phylogenetic characterization and prevalence of "Spirobacillus cienkowskii," a red-pigmented, spiral-shaped bacterial pathogen of freshwater Daphnia species.	Rodrigues JL, Duffy MA, Tessier AJ, Ebert D, Mouton L, Schmidt TM.	Appl Environ Microbiol	10.1128/aem.02438-07	2008
	Artificial neural networks for the diagnosis of aggressive periodontitis trained by immunologic parameters.	Papantonopoulos G, Takahashi K, Bountis T, Loos BG.	PLoS One	10.1371/journal.pone.0089757	2014
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Enzymology	Synthesis and secretion of phospholipase C by oral spirochetes.	Siboo R, al-Joburi W, Gornitsky M, Chan EC.	J Clin Microbiol	10.1128/jcm.27.3.568-570.1989	1989
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Metabolism	Molecular Evolution of the Oxygen-Binding Hemerythrin Domain.	Alvarez-Carreno C, Becerra A, Lazcano A.	PLoS One	10.1371/journal.pone.0157904	2016
	Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.	Simonson LG, Rouse RF, Bockowski SW.	Infect Immun	10.1128/iai.56.1.60-63.1988	1988
	In search of RNase P RNA from microbial genomes.	Li Y, Altman S.	RNA	10.1261/rna.7970404	2004
Metabolism	Treponema denticola outer membrane inhibits calcium flux in gingival fibroblasts.	Ko KS, Glogauer M, McCulloch CA, Ellen RP.	Infect Immun	10.1128/iai.66.2.703-709.1998	1998
	Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible.	Harper KN, Fyumagwa RD, Hoare R, Wambura PN, Coppenhaver DH, Sapolsky RM, Alberts SC, Tung J, Rogers J, Kilewo M, Batamuzi EK, Leendertz FH, Armelagos GJ, Knauf S.	PLoS One	10.1371/journal.pone.0050882	2012
	Monitoring the prevalence of viable and dead cariogenic bacteria in oral specimens and in vitro biofilms by qPCR combined with propidium monoazide.	Yasunaga A, Yoshida A, Morikawa K, Maki K, Nakamura S, Soh I, Awano S, Ansai T.	BMC Microbiol	10.1186/1471-2180-13-157	2013
	Lesion formation and antibody response induced by papillomatous digital dermatitis-associated spirochetes in a murine abscess model.	Elliott MK, Alt DP, Zuerner RL.	Infect Immun	10.1128/iai.00019-07	2007
Enzymology	Insights into the virulence of oral biofilms: discoveries from proteomics.	Kuboniwa M, Tribble GD, Hendrickson EL, Amano A, Lamont RJ, Hackett M.	Expert Rev Proteomics	10.1586/epr.12.16	2012
	Cloning and characterization of a gene (mspA) encoding the major sheath protein of Treponema maltophilum ATCC 51939(T).	Heuner K, Choi BK, Schade R, Moter A, Otto A, Gobel UB.	J Bacteriol	10.1128/jb.181.3.1025-1029.1999	1999
Enzymology	BactQuant: an enhanced broad-coverage bacterial quantitative real-time PCR assay.	Liu CM, Aziz M, Kachur S, Hsueh PR, Huang YT, Keim P, Price LB.	BMC Microbiol	10.1186/1471-2180-12-56	2012
Enzymology	Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis.	Riviere GR, Weisz KS, Simonson LG, Lukehart SA.	Infect Immun	10.1128/iai.59.8.2653-2657.1991	1991
	Transcriptional regulatory network discovery via multiple method integration: application to e. coli K12.	Sun J, Tuncay K, Haidar AA, Ensman L, Stanley F, Trelinski M, Ortoleva P.	Algorithms Mol Biol	10.1186/1748-7188-2-2	2007
Phylogeny	Comparative genomic analyses of the bacterial phosphotransferase system.	Barabote RD, Saier MH.	Microbiol Mol Biol Rev	10.1128/mmbr.69.4.608-634.2005	2005
Enzymology	Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences.	Bourhy P, Bremont S, Zinini F, Giry C, Picardeau M.	J Clin Microbiol	10.1128/jcm.02452-10	2011
	Biochemical properties of the outer membrane of Treponema denticola.	Yotis WW, Sharma VK, Gopalsami C, Chegini S, McNulty J, Hoerman K, Keene J, Simonson LG.	J Clin Microbiol	10.1128/jcm.29.7.1397-1406.1991	1991
Enzymology	Comparison of the benzoyl-DL-arginine-naphthylamide (BANA) test, DNA probes, and immunological reagents for ability to detect anaerobic periodontal infections due to Porphyromonas gingivalis, Treponema denticola, and Bacteroides forsythus.	Loesche WJ, Lopatin DE, Giordano J, Alcoforado G, Hujoel P.	J Clin Microbiol	10.1128/jcm.30.2.427-433.1992	1992
Metabolism	Development of a diagnostic test for anaerobic periodontal infections based on plaque hydrolysis of benzoyl-DL-arginine-naphthylamide.	Loesche WJ, Bretz WA, Kerschensteiner D, Stoll J, Socransky SS, Hujoel P, Lopatin DE.	J Clin Microbiol	10.1128/jcm.28.7.1551-1559.1990	1990
Metabolism	A machine learning approach to identify hydrogenosomal proteins in Trichomonas vaginalis.	Burstein D, Gould SB, Zimorski V, Kloesges T, Kiosse F, Major P, Martin WF, Pupko T, Dagan T.	Eukaryot Cell	10.1128/ec.05225-11	2012
	The vaginal microflora in relation to gingivitis.	Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D.	BMC Infect Dis	10.1186/1471-2334-9-6	2009
	Interaction of Treponema denticola TD-4, GM-1, and MS25 with human gingival fibroblasts.	Weinberg A, Holt SC.	Infect Immun	10.1128/iai.58.6.1720-1729.1990	1990
Metabolism	Eubacterial SpoVG homologs constitute a new family of site-specific DNA-binding proteins.	Jutras BL, Chenail AM, Rowland CL, Carroll D, Miller MC, Bykowski T, Stevenson B.	PLoS One	10.1371/journal.pone.0066683	2013
Enzymology	Identification of a new Borrelia species among small mammals in areas of northern Spain where Lyme disease is endemic.	Gil H, Barral M, Escudero R, Garcia-Perez AL, Anda P.	Appl Environ Microbiol	10.1128/aem.71.3.1336-1345.2005	2005
Phylogeny	Characterization of novel bovine gastrointestinal tract Treponema isolates and comparison with bovine digital dermatitis treponemes.	Evans NJ, Brown JM, Murray RD, Getty B, Birtles RJ, Hart CA, Carter SD.	Appl Environ Microbiol	10.1128/aem.00993-10	2011
	Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections.	Lee SH, Kim KK, Choi BK.	Infect Immun	10.1128/iai.73.1.268-276.2005	2005
Metabolism	Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.	Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N.	Am J Pathol	10.2353/ajpath.2006.050658	2006
Enzymology	Comparison of various detection methods for periodontopathic bacteria: can culture be considered the primary reference standard?	Loesche WJ, Lopatin DE, Stoll J, van Poperin N, Hujoel PP.	J Clin Microbiol	10.1128/jcm.30.2.418-426.1992	1992
Genetics	A comprehensive benchmarking study of protocols and sequencing platforms for 16S rRNA community profiling.	D'Amore R, Ijaz UZ, Schirmer M, Kenny JG, Gregory R, Darby AC, Shakya M, Podar M, Quince C, Hall N.	BMC Genomics	10.1186/s12864-015-2194-9	2016
Phylogeny	Phage_Finder: automated identification and classification of prophage regions in complete bacterial genome sequences.	Fouts DE.	Nucleic Acids Res	10.1093/nar/gkl732	2006
	A database of bacterial lipoproteins (DOLOP) with functional assignments to predicted lipoproteins.	Babu MM, Priya ML, Selvan AT, Madera M, Gough J, Aravind L, Sankaran K.	J Bacteriol	10.1128/jb.188.8.2761-2773.2006	2006
Metabolism	Identification of prophages in bacterial genomes by dinucleotide relative abundance difference.	Srividhya KV, Alaguraj V, Poornima G, Kumar D, Singh GP, Raghavenderan L, Katta AV, Mehta P, Krishnaswamy S.	PLoS One	10.1371/journal.pone.0001193	2007
Metabolism	Identification of surprisingly diverse type IV pili, across a broad range of gram-positive bacteria.	Imam S, Chen Z, Roos DS, Pohlschroder M.	PLoS One	10.1371/journal.pone.0028919	2011
	Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice.	Benoit VM, Petrich A, Alugupalli KR, Marty-Roix R, Moter A, Leong JM, Boyartchuk VL.	Infect Immun	10.1128/iai.01216-09	2010
	Evaluation of gel-pad oligonucleotide microarray technology by using artificial neural networks.	Pozhitkov A, Chernov B, Yershov G, Noble PA.	Appl Environ Microbiol	10.1128/aem.71.12.8663-8676.2005	2005
Genetics	Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics.	Noel CJ, Diaz N, Sicheritz-Ponten T, Safarikova L, Tachezy J, Tang P, Fiori PL, Hirt RP.	BMC Genomics	10.1186/1471-2164-11-99	2010
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Genetics	Minimum contradiction matrices in whole genome phylogenies.	Thuillard M.	Evol Bioinform Online	10.4137/ebo.s909	2008
Transcriptome	Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile.	Brouwer MS, Warburton PJ, Roberts AP, Mullany P, Allan E.	PLoS One	10.1371/journal.pone.0023014	2011
Phylogeny	Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins.	Shlykov MA, Zheng WH, Chen JS, Saier MH.	Biochim Biophys Acta	10.1016/j.bbamem.2011.12.005	2012
Metabolism	Proteolytic activation of the interleukin-1beta precursor by Candida albicans.	Beausejour A, Grenier D, Goulet JP, Deslauriers N.	Infect Immun	10.1128/iai.66.2.676-681.1998	1998
Metabolism	Evolutionary primacy of sodium bioenergetics.	Mulkidjanian AY, Galperin MY, Makarova KS, Wolf YI, Koonin EV.	Biol Direct	10.1186/1745-6150-3-13	2008
	Identification of SmtB/ArsR cis elements and proteins in archaea using the Prokaryotic InterGenic Exploration Database (PIGED).	Bose M, Slick D, Sarto MJ, Murphy P, Roberts D, Roberts J, Barber RD.	Archaea	10.1155/2006/837139	2006
Enzymology	Application of monoclonal antibodies to the detection of black-pigmented Bacteroides spp. in subgingival plaques by immunoslot blot assay.	Hanazawa S, Tanaka S, Kin M, Amano S, Nakada K, Masuda T, Kitano S.	J Clin Microbiol	10.1128/jcm.28.10.2248-2252.1990	1990
Metabolism	Synthesis of autoinducer 2 by the lyme disease spirochete, Borrelia burgdorferi.	Babb K, von Lackum K, Wattier RL, Riley SP, Stevenson B.	J Bacteriol	10.1128/jb.187.9.3079-3087.2005	2005
Enzymology	Comparison of randomly cloned and whole genomic DNA probes for the detection of Porphyromonas gingivalis and Bacteroides forsythus.	Wong M, DiRienzo JM, Lai CH, Listgarten MA.	J Periodontal Res	10.1111/j.1600-0765.1996.tb00460.x	1996
Metabolism	Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease.	Ghannad F, Nica D, Fulle MI, Grenier D, Putnins EE, Johnston S, Eslami A, Koivisto L, Jiang G, McKee MD, Hakkinen L, Larjava H.	Am J Pathol	10.2353/ajpath.2008.071068	2008
Metabolism	Binding and utilization of human transferrin by Prevotella nigrescens.	Duchesne P, Grenier D, Mayrand D.	Infect Immun	10.1128/iai.67.2.576-580.1999	1999
	Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.	Pieper U, Chiang R, Seffernick JJ, Brown SD, Glasner ME, Kelly L, Eswar N, Sauder JM, Bonanno JB, Swaminathan S, Burley SK, Zheng X, Chance MR, Almo SC, Gerlt JA, Raushel FM, Jacobson MP, Babbitt PC, Sali A.	J Struct Funct Genomics	10.1007/s10969-008-9056-5	2009
Enzymology	Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis.	Masuda K, Yoshioka M, Hinode D, Nakamura R.	Infect Immun	10.1128/iai.70.4.1807-1815.2002	2002
	Slot immunoblot assay for detection and quantitation of periodontal disease-associated microorganisms in dental plaque.	van Poperin N, Lopatin DE.	J Clin Microbiol	10.1128/jcm.29.11.2554-2558.1991	1991
	Metabolic network model of a human oral pathogen.	Mazumdar V, Snitkin ES, Amar S, Segre D.	J Bacteriol	10.1128/jb.01123-08	2009
Enzymology	Regulation of sucrose-6-phosphate hydrolase activity in Streptococcus mutans: characterization of the scrR gene.	Hiratsuka K, Wang B, Sato Y, Kuramitsu H.	Infect Immun	10.1128/iai.66.8.3736-3743.1998	1998
	The TetR family of transcriptional repressors.	Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R.	Microbiol Mol Biol Rev	10.1128/mmbr.69.2.326-356.2005	2005
Metabolism	Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life.	Gillespie JJ, Williams K, Shukla M, Snyder EE, Nordberg EK, Ceraul SM, Dharmanolla C, Rainey D, Soneja J, Shallom JM, Vishnubhat ND, Wattam R, Purkayastha A, Czar M, Crasta O, Setubal JC, Azad AF, Sobral BS.	PLoS One	10.1371/journal.pone.0002018	2008
Pathogenicity	The effects of different restorative materials on periodontopathogens in combined restorative-periodontal treatment.	Isler SC, Ozcan G, Akca G, Kocabas Z.	J Appl Oral Sci	10.1590/1678-7757-2017-0154	2018
	Oral Probiotics, Streptococcus salivarius K12 and M18, Suppress the Release of Volatile Sulfur Compounds and a Virulent Protease from Oral Bacteria: An In-Vitro Study.	Park JA, Lee GR, Lee JY, Jin BH.	Oral Health Prev Dent	10.3290/j.ohpd.b4328987	2023
	Antiperiodontitis Effects of Siegesbeckia glabrescens In Vitro.	Bellere AD, Yu D, Oh S, Kim M, Jung J, Fang M, Zheng S, Yi TH.	Antioxidants (Basel)	10.3390/antiox12020471	2023
	Prevalence and abundance of 9 periodontal pathogens in the saliva of periodontally healthy adults and patients undergoing supportive periodontal therapy.	Jung WR, Joo JY, Lee JY, Kim HJ.	J Periodontal Implant Sci	10.5051/jpis.2006640332	2021
	Real-time PCR quantification of 9 periodontal pathogens in saliva samples from periodontally healthy Korean young adults.	Choi H, Kim E, Kang J, Kim HJ, Lee JY, Choi J, Joo JY.	J Periodontal Implant Sci	10.5051/jpis.2018.48.4.261	2018
Enzymology	Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva.	Kim EH, Joo JY, Lee YJ, Koh JK, Choi JH, Shin Y, Cho J, Park E, Kang J, Lee K, Bhak J, Kim BC, Lee JY.	PLoS One	10.1371/journal.pone.0200900	2018
	Identification of protein targets in red complex organisms binding with resveratrol.	Pothapur KK, Vishnu Priya V, Rengasamy G, Jayaseelan VP	Bioinformation	10.6026/97320630016837	2020
	Protein targets in the red complex organisms binding with an herbal compound silymarin.	Faiz N, Pothapur KK, Vishnupriya V, Gayathri R, Priyadharsini JV	Bioinformation	10.6026/97320630016759	2020
	Identification of aspirin and diclofenac binding proteins in the red complex pathogens.	Babu G, Priya VV, Krishnaa PK, Gayathri R, Priyadharsini JV	Bioinformation	10.6026/97320630017192	2021
	Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in Treponema denticola.	Arai Y, Kikuchi Y, Okamoto-Shibayama K, Kokubu E, Shintani S, Ishihara K	J Oral Microbiol	10.1080/20002297.2020.1829404	2020
Enzymology	Immunotopological Analysis of the Treponema denticola Major Surface Protein (Msp).	Godovikova V, Goetting-Minesky MP, Timm JC, Fenno JC	J Bacteriol	10.1128/JB.00528-18	2018
Pathogenicity	Treponema denticola Induces Epithelial Barrier Dysfunction in Polarized Epithelial Cells.	Kikuchi Y, Kimizuka R, Kato T, Okuda K, Kokubu E, Ishihara K	Bull Tokyo Dent Coll	10.2209/tdcpublication.2017-0052	2018
	Effect of azithromycin on a red complex polymicrobial biofilm.	Ong HS, Oettinger-Barak O, Dashper SG, Darby IB, Tan KH, Reynolds EC	J Oral Microbiol	10.1080/20002297.2017.1339579	2017
Phylogeny	Oral treponeme major surface protein: Sequence diversity and distributions within periodontal niches.	You M, Chan Y, Lacap-Bugler DC, Huo YB, Gao W, Leung WK, Watt RM	Mol Oral Microbiol	10.1111/omi.12185	2017
Metabolism	Comparative analysis of motility and other properties of Treponema denticola strains.	Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F	Microb Pathog	10.1016/j.micpath.2016.11.021	2016
Enzymology	Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola.	Tanaka-Kumazawa K, Kikuchi Y, Sano-Kokubun Y, Shintani S, Yakushiji M, Kuramitsu HK, Ishihara K	BMC Oral Health	10.1186/s12903-016-0243-7	2016
	Genomic and Metagenomic Analysis of Diversity-Generating Retroelements Associated with Treponema denticola.	Nimkulrat S, Lee H, Doak TG, Ye Y	Front Microbiol	10.3389/fmicb.2016.00852	2016
Pathogenicity	A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405.	Godovikova V, Goetting-Minesky MP, Shin JM, Kapila YL, Rickard AH, Fenno JC	Appl Environ Microbiol	10.1128/AEM.01541-15	2015
	Kanamycin Resistance Cassette for Genetic Manipulation of Treponema denticola.	Li Y, Ruby J, Wu H	Appl Environ Microbiol	10.1128/AEM.00478-15	2015
Metabolism	Dentilisin involvement in coaggregation between Treponema denticola and Tannerella forsythia.	Sano Y, Okamoto-Shibayama K, Tanaka K, Ito R, Shintani S, Yakushiji M, Ishihara K	Anaerobe	10.1016/j.anaerobe.2014.08.008	2014
Enzymology	Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex.	Goetting-Minesky MP, Godovikova V, Li JJ, Seshadrinathan S, Timm JC, Kamodia SS, Fenno JC	Mol Oral Microbiol	10.1111/omi.12013	2012
Enzymology	Disruption of a type II endonuclease (TDE0911) enables Treponema denticola ATCC 35405 to accept an unmethylated shuttle vector.	Bian J, Li C	Appl Environ Microbiol	10.1128/AEM.00417-11	2011
Pathogenicity	Mixture of periodontopathogenic bacteria influences interaction with KB cells.	Kirschbaum M, Schultze-Mosgau S, Pfister W, Eick S	Anaerobe	10.1016/j.anaerobe.2010.03.009	2010
Enzymology	Human serum antibodies recognize Treponema denticola Msp and PrtP protease complex proteins.	Capone R, Wang HT, Ning Y, Sweier DG, Lopatin DE, Fenno JC	Oral Microbiol Immunol	10.1111/j.1399-302X.2007.00404.x	2008
Metabolism	Steroid 5alpha-reductase activity of Treponema denticola.	Clark DT, Soory M	Oral Microbiol Immunol	10.1111/j.1399-302X.2007.00364.x	2007
Metabolism	The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation.	Bamford CV, Fenno JC, Jenkinson HF, Dymock D	Infect Immun	10.1128/IAI.00258-07	2007
Pathogenicity	Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells.	Okuda T, Kimizuka R, Miyamoto M, Kato T, Yamada S, Okuda K, Ishihara K	Microbes Infect	10.1016/j.micinf.2007.03.009	2007
Metabolism	Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.	Capone RF, Ning Y, Pakulis N, Alhazzazi T, Fenno JC	FEMS Microbiol Lett	10.1111/j.1574-6968.2006.00589.x	2006
Metabolism	Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes.	Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K	Microbes Infect	10.1016/j.micinf.2006.02.013	2006
Metabolism	Binding properties and adhesion-mediating regions of the major sheath protein of Treponema denticola ATCC 35405.	Edwards AM, Jenkinson HF, Woodward MJ, Dymock D	Infect Immun	10.1128/IAI.73.5.2891-2898.2005	2005
Metabolism	Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola.	Ikegami A, Honma K, Sharma A, Kuramitsu HK	Infect Immun	10.1128/IAI.72.8.4619-4627.2004	2004
Metabolism	Genetic analysis of Treponema denticola ATCC 35405 biofilm formation.	Vesey PM, Kuramitsu HK	Microbiology (Reading)	10.1099/mic.0.26816-0	2004
Metabolism	Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.	Seshadri R, Myers GS, Tettelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT	Proc Natl Acad Sci U S A	10.1073/pnas.0307639101	2004
Phylogeny	Genetic relatedness and phenotypic characteristics of Treponema associated with human periodontal tissues and ruminant foot disease.	Edwards AM, Dymock D, Woodward MJ, Jenkinson HF	Microbiology (Reading)	10.1099/mic.0.26111-0	2003
Pathogenicity	Treponema denticola may stimulate both epithelial proliferation and apoptosis through MAP kinase signal pathways.	Leung WK, Wu Q, Hannam PM, McBride BC, Uitto VJ	J Periodontal Res	10.1034/j.1600-0765.2002.01007.x	2002
Pathogenicity	Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola.	Lux R, Miller JN, Park NH, Shi W	Infect Immun	10.1128/IAI.69.10.6276-6283.2001	2001
Pathogenicity	Insertional inactivation of the prtP gene of Treponema denticola confirms dentilisin's disruption of epithelial junctions.	Ellen RP, Ko KS, Lo CM, Grove DA, Ishihara K	J Mol Microbiol Biotechnol		2000
Metabolism	Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment.	Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC	Infect Immun	10.1128/IAI.68.4.1884-1892.2000	2000
Pathogenicity	Molecular characterization of a flagellar (fla) operon in the oral spirochete Treponema denticola ATCC 35405.	Stamm LV, Bergen HL	FEMS Microbiol Lett	10.1111/j.1574-6968.1999.tb08703.x	1999
Phylogeny	Mitogenic activity of the outer membrane of Treponema denticola.	Schade SZ, Yotis WW, Gopalsami C, Simonson LG	Microbios		1998
Metabolism	Oxygen metabolism by Treponema denticola.	Caldwell CE, Marquis RE	Oral Microbiol Immunol	10.1034/j.1399-302x.1999.140109.x	1999
Metabolism	Treponema denticola outer membrane enhances the phagocytosis of collagen-coated beads by gingival fibroblasts.	Battikhi T, Lee W, McCulloch CA, Ellen RP	Infect Immun	10.1128/IAI.67.3.1220-1226.1999	1999
Pathogenicity	Characterization of a novel methyl-accepting chemotaxis gene, dmcB, from the oral spirochete Treponema denticola.	Li H, Arakawa S, Deng QD, Kuramitsu H	Infect Immun	10.1128/IAI.67.2.694-699.1999	1999
Enzymology	Mutagenesis of outer membrane virulence determinants of the oral spirochete Treponema denticola.	Fenno JC, Wong GW, Hannam PM, McBride BC	FEMS Microbiol Lett	10.1111/j.1574-6968.1998.tb13047.x	1998
Metabolism	Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola.	Yang PF, Song M, Grove DA, Ellen RP	Infect Immun	10.1128/IAI.66.2.696-702.1998	1998
Enzymology	Identification, isolation, and characterization of the 42-kilodalton major outer membrane protein (MompA) from Treponema pectinovorum ATCC 33768.	Walker SG, Ebersole JL, Holt SC	J Bacteriol	10.1128/jb.179.20.6441-6447.1997	1997
Genetics	Characterization of a methyl-accepting chemotaxis protein gene, dmcA, from the oral spirochete Treponema denticola.	Kataoka M, Li H, Arakawa S, Kuramitsu H	Infect Immun	10.1128/iai.65.10.4011-4016.1997	1997
Pathogenicity	Genetic and transcriptional analysis of flgB flagellar operon constituents in the oral spirochete Treponema denticola and their heterologous expression in enteric bacteria.	Heinzerling HF, Olivares M, Burne RA	Infect Immun	10.1128/iai.65.6.2041-2051.1997	1997
Metabolism	Visualization of an extracellular mucoid layer of Treponema denticola ATCC 35405 and surface sugar lectin analysis of some Treponema species.	Scott D, Klitorinos A, Chan EC, Siboo R	Oral Microbiol Immunol	10.1111/j.1399-302x.1997.tb00628.x	1997
Genetics	Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.	Fenno JC, Wong GW, Hannam PM, Muller KH, Leung WK, McBride BC	J Bacteriol	10.1128/jb.179.4.1082-1089.1997	1997
Enzymology	gamma-Glutamyltransferase from the outer cell envelope of Treponema denticola ATCC 35405.	Makinen PL, Makinen KK	Infect Immun	10.1128/iai.65.2.685-691.1997	1997
Enzymology	Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin).	Ishihara K, Miura T, Kuramitsu HK, Okuda K	Infect Immun	10.1128/iai.64.12.5178-5186.1996	1996
Enzymology	Iron acquisition by oral hemolytic spirochetes: isolation of a hemin-binding protein and identification of iron reductase activity.	Scott D, Chan EC, Siboo R	Can J Microbiol	10.1139/m96-137	1996
Metabolism	The major surface protein complex of Treponema denticola depolarizes and induces ion channels in HeLa cell membranes.	Mathers DA, Leung WK, Fenno JC, Hong Y, McBride BC	Infect Immun	10.1128/iai.64.8.2904-2910.1996	1996
Metabolism	Hyaluronan, a possible ligand mediating Treponema denticola binding to periodontal tissue.	Haapasalo M, Hannam P, McBride BC, Uitto VJ	Oral Microbiol Immunol	10.1111/j.1399-302x.1996.tb00351.x	1996
Genetics	Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant.	Li H, Ruby J, Charon N, Kuramitsu H	J Bacteriol	10.1128/jb.178.12.3664-3667.1996	1996
Metabolism	Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola.	Fenno JC, Muller KH, McBride BC	J Bacteriol	10.1128/jb.178.9.2489-2497.1996	1996
Enzymology	Proline iminopeptidase from the outer cell envelope of the human oral spirochete Treponema denticola ATCC 35405.	Makinen KK, Chen CY, Makinen PL	Infect Immun	10.1128/iai.64.3.702-708.1996	1996
Metabolism	Role of the chymotrypsin-like membrane-associated proteinase from Treponema denticola ATCC 35405 in inactivation of bioactive peptides.	Makinen PL, Makinen KK, Syed SA	Infect Immun	10.1128/iai.63.9.3567-3575.1995	1995
Pathogenicity	Identification of a fliG homologue in Treponema denticola.	Heinzerling HF, Penders JE, Burne RA	Gene	10.1016/0378-1119(95)00257-7	1995
Phenotype	Evidence for two distinct locomotory phenotypes of Treponema denticola ATCC 35405.	Chan EC, Qiu YS, Siboo R, Noble P	Oral Microbiol Immunol	10.1111/j.1399-302x.1995.tb00131.x	1995
Enzymology	Cloning and expression of a neutral phosphatase gene from Treponema denticola.	Ishihara K, Kuramitsu HK	Infect Immun	10.1128/iai.63.4.1147-1152.1995	1995
Pathogenicity	Induction of cytoskeletal rearrangements and loss of volume regulation in epithelial cells by Treponema denticola.	De Filippo AB, Ellen RP, McCulloch CA	Arch Oral Biol	10.1016/0003-9969(95)98809-d	1995
Enzymology	Purification and general properties of an oligopeptidase from Treponema denticola ATCC 35405--a human oral spirochete.	Makinen KK, Makinen PL, Loesche WJ, Syed SA	Arch Biochem Biophys	10.1006/abbi.1995.1092	1995
Metabolism	An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides.	Makinen PL, Makinen KK, Syed SA	Infect Immun	10.1128/iai.62.11.4938-4947.1994	1994
Enzymology	Cloning and sequence analysis of a chymotrypsinlike protease from Treponema denticola.	Arakawa S, Kuramitsu HK	Infect Immun	10.1128/iai.62.8.3424-3433.1994	1994
Enzymology	Isolation and characterization of a 53 kDa major cell envelope protein antigen from Treponema denticola ATCC 35405.	Kokeguchi S, Miyamoto M, Kato K, Tanimoto I, Kurihara H, Murayama Y	J Periodontal Res	10.1111/j.1600-0765.1994.tb01093.x	1994
Metabolism	Proteolytic and oxidoreductase activity of Treponema denticola ATCC 35405 grown in an aerobic and anaerobic gaseous environment.	Syed SA, Makinen KK, Makinen PL, Chen CY, Muhammad Z	Res Microbiol	10.1016/0923-2508(93)90016-u	1993
Pathogenicity	Treponema denticola induces actin rearrangement and detachment of human gingival fibroblasts.	Baehni PC, Song M, McCulloch CA, Ellen RP	Infect Immun	10.1128/iai.60.8.3360-3368.1992	1992
Enzymology	Purification and substrate specificity of an endopeptidase from the human oral spirochete Treponema denticola ATCC 35405, active on furylacryloyl-Leu-Gly-Pro-Ala and bradykinin.	Makinen KK, Makinen PL, Syed SA	J Biol Chem	S0021-9258(19)49710-X	1992
Enzymology	Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen.	Haapasalo M, Muller KH, Uitto VJ, Leung WK, McBride BC	Infect Immun	10.1128/iai.60.5.2058-2065.1992	1992
Metabolism	Sulfhydryl-dependent attachment of Treponema denticola to laminin and other proteins.	Haapasalo M, Singh U, McBride BC, Uitto VJ	Infect Immun	10.1128/iai.59.11.4230-4237.1991	1991
Enzymology	Isolation and characterization of the Treponema denticola prtA gene coding for chymotrypsinlike protease activity and detection of a closely linked gene encoding PZ-PLGPA-hydrolyzing activity.	Que XC, Kuramitsu HK	Infect Immun	10.1128/iai.58.12.4099-4105.1990	1990
Enzymology	Enzyme profiles of oral spirochetes in RapID-ANA system.	Syed SA, Salvador SL, Loesche WJ	J Clin Microbiol	10.1128/jcm.26.10.2226-2228.1988	1988
Enzymology	Isolation of a chymotrypsinlike enzyme from Treponema denticola.	Uitto VJ, Grenier D, Chan EC, McBride BC	Infect Immun	10.1128/iai.56.10.2717-2722.1988	1988
	Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes.	Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M	PLoS One	10.1371/journal.pone.0270198	2022
Phylogeny	Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets.	Chan EC, Siboo R, Keng T, Psarra N, Hurley R, Cheng SL, Iugovaz I	Int J Syst Bacteriol	10.1099/00207713-43-2-196	1993

References

#5260	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 14222
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Treponema denticola (DSM 14222, ATCC 35405, JCM 8153)

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