Treponema denticola (JCM 8152, ATCC 35404, CIP 103920)

Name: Treponema denticola (JCM 8152, ATCC 35404, CIP 103920)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 165755

Type strain

Culture col. no. JCM 8152 ATCC 35404 CIP 103920

NCBI tax ID(s) 999430 158

Special Collections JCM CIP

Links

Treponema denticola JCM 8152 is a mesophilic prokaryote that was isolated from Human oral cavity.

mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 46785

ATCC 35404,CIP 103920,JCM 8152

@ref 20215

Last LPSN update 2025-12-16 10:09:45

Domain Pseudomonadati

Phylum Spirochaetota

Class Spirochaetia

Order Spirochaetales

Family Treponemataceae

Genus Treponema

Species Treponema denticola

Full scientific name Treponema denticola (ex Flügge 1886) Chan et al. 1993

Synonyms (1)

"Treponema denticola"

BacDive ID	Other strains from **Treponema denticola** (4)	Type strain
14344	T. denticola DSM 14222, ATCC 35405, JCM 8153, CIP 103919, ... (type strain)
138912	T. denticola CIP 64.44
165774	T. denticola JCM 8225, ATCC 33520, CIP 103917
165775	T. denticola JCM 8226, ATCC 33521, CIP 103917

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	99.7

Culture and growth conditions

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	anaerobe	91.251

Spore formation

@ref	Spore formation	Confidence
125439		99.7

Isolation, sampling and environmental information

Isolation

67770

Sample typeHuman oral cavity

Taxonmaps

69479

Global distribution of 16S sequence LC037215 (>99% sequence identity) for Treponema denticola from Microbeatlas

Aquatic Samples	521
Soil Samples	517
Animal Samples	28134
Plant Samples	223
Total Samples	29395

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Trep_dent_ATCC_35404_V1 assembly for Treponema denticola ATCC 35404	chromosome	GCA_000340685	999430.5	2537561890	999430	66.89

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
67770	Treponema denticola gene for 16S ribosomal RNA, partial sequence, strain: JCM 8152	LC037215	1506		158
124043	Treponema denticola strain ATCC35404 16S ribosomal RNA gene, partial sequence.	AF139204	1450		999430

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Treponema denticola ATCC 35404
PATRIC: 999430.5

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	99.70	no
125439	motility	BacteriaNetⓘ	no	63.00	no
125439	gram_stain	BacteriaNetⓘ	negative	99.70	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	72.60	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Treponema denticola ATCC 35404
PATRIC: 999430.5

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	83.65	no
125438	anaerobic	anaerobicⓘ	yes	91.25	no
125438	aerobic	aerobicⓘ	no	96.88	no
125438	spore-forming	spore-formingⓘ	no	79.36	no
125438	thermophilic	thermophileⓘ	no	87.38	no
125438	flagellated	motile2+ⓘ	yes	59.04	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.	Yabuuchi S, Oiki S, Minami S, Takase R, Watanabe D, Hashimoto W.	Sci Rep	10.1038/s41598-022-14857-9	2022
	Microbial Coaggregation in the Oral Cavity: Molecular Interactions and Current Insights.	Oogai Y, Tanaka Y, Nakata M.	Int J Mol Sci	10.3390/ijms262110552	2025
	Role of Nitric Oxide and Nrf2 to Counteract Vascular Endothelial Dysfunction Induced by Periodontal Pathogens Using HUVECs.	Dhungana G, Sampath C, Sharma V, Korolkova O, Gangula PR.	Cells	10.3390/cells14221777	2025
Pathogenicity	Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection.	Jeepipalli S, Gurusamy P, Martins ARL, Colella E, Nadakuditi SR, Desaraju T, Yada A, Onime J, William JT, Bhattacharyya I, Chan EKL, Kesavalu L.	Microbiol Spectr	10.1128/spectrum.00160-25	2025
	Polybacterial Periodontal Infection Alters oxidative and Inflammatory Biomarkers in Primary Human Aortic Endothelial Cell (pHAECs).	Sampath C, Campbell M, Baptiste J, Carter J, Greene MS, Dhungana G, Chukkapalli S, Gangula PR.	J Pharm Pharmacol Res	10.26502/fjppr.0108	2025
Genetics	Integrative analysis of gene and protein expression in atherosclerosis-related pathways modulated by periodontal pathogens. Systematic review.	Marroquin TY, Guauque-Olarte S.	Jpn Dent Sci Rev	10.1016/j.jdsr.2022.12.001	2023
	Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes.	Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M.	PLoS One	10.1371/journal.pone.0270198	2022
Metabolism	Multiple enzymes can make hydrogen sulfide from cysteine in Treponema denticola.	Phillips L, Chu L, Kolodrubetz D.	Anaerobe	10.1016/j.anaerobe.2020.102231	2020
Metabolism	Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola.	Tanaka-Kumazawa K, Kikuchi Y, Sano-Kokubun Y, Shintani S, Yakushiji M, Kuramitsu HK, Ishihara K.	BMC Oral Health	10.1186/s12903-016-0243-7	2016
	Metabolic engineering of Escherichia coli for the production of butyric acid at high titer and productivity.	Wang L, Chauliac D, Moritz BE, Zhang G, Ingram LO, Shanmugam KT.	Biotechnol Biofuels	10.1186/s13068-019-1408-9	2019
	Investigation of the effects of Bipolar Radiofrequency Energy on the Structural Morphology of Dental Plaque.	Amaechi BT, Mohseni S, Dillow AM, Abdul Azees PA, Movaghari Pour F, Kataoka Y, Restrepo MC.	Eur J Dent	10.1055/s-0043-1764427	2024
	Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).	Michikawa C, Gopalakrishnan V, Harrandah AM, Karpinets TV, Garg RR, Chu RA, Park YP, Chukkapallia SS, Yadlapalli N, Erikson-Carter KC, Gleber-Netto FO, Sayour E, Progulske-Fox A, Chan EKL, Wu X, Zhang J, Jobin C, Wargo JA, Pickering CR, Myers JN, Silver N.	Neoplasia	10.1016/j.neo.2022.100813	2022
Phylogeny	Multilocus sequence analysis of Treponema denticola strains of diverse origin.	Mo S, You M, Su YC, Lacap-Bugler DC, Huo YB, Smith GJ, Leung WK, Leung WK, Leung WK, Watt RM.	BMC Microbiol	10.1186/1471-2180-13-24	2013
	Selective bacterial degradation of the extracellular matrix attaching the gingiva to the tooth.	Fouillen A, Grenier D, Barbeau J, Baron C, Moffatt P, Nanci A.	Eur J Oral Sci	10.1111/eos.12623	2019
Pathogenicity	Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice.	Chukkapalli SS, Easwaran M, Rivera-Kweh MF, Velsko IM, Ambadapadi S, Dai J, Larjava H, Lucas AR, Kesavalu L.	Pathog Dis	10.1093/femspd/ftx003	2017
Metabolism	The antibacterial activity of LL-37 against Treponema denticola is dentilisin protease independent and facilitated by the major outer sheath protein virulence factor.	Rosen G, Sela MN, Bachrach G.	Infect Immun	10.1128/iai.05903-11	2012
	Mixed red-complex bacterial infection in periodontitis.	Suzuki N, Yoneda M, Hirofuji T.	Int J Dent	10.1155/2013/587279	2013
Metabolism	Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease.	Nayar G, Gauna A, Chukkapalli S, Velsko I, Kesavalu L, Cha S.	Anaerobe	10.1016/j.anaerobe.2015.10.005	2016
Phylogeny	Multilocus Sequence Analysis of Phylogroup 1 and 2 Oral Treponeme Strains.	Huo YB, Chan Y, Lacap-Bugler DC, Mo S, Woo PCY, Leung WK, Watt RM.	Appl Environ Microbiol	10.1128/aem.02499-16	2017
Pathogenicity	Treponema denticola is resistant to human beta-defensins.	Brissette CA, Lukehart SA.	Infect Immun	10.1128/iai.70.7.3982-3984.2002	2002
Metabolism	A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.	Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.	J Biol Chem	10.1074/jbc.m801034200	2008
Metabolism	Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles.	Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Verma RK, Wallet SM, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L.	Mol Oral Microbiol	10.1111/j.2041-1014.2010.00575.x	2010
	Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study.	Demmer RT, Jacobs DR, Singh R, Zuk A, Rosenbaum M, Papapanou PN, Desvarieux M.	J Dent Res	10.1177/0022034515590369	2015
Metabolism	Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.	Oktay S, Chukkapalli SS, Rivera-Kweh MF, Velsko IM, Holliday LS, Kesavalu L.	J Periodontol	10.1902/jop.2014.140302	2015
Enzymology	Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex.	Goetting-Minesky MP, Godovikova V, Li JJ, Seshadrinathan S, Timm JC, Kamodia SS, Fenno JC.	Mol Oral Microbiol	10.1111/omi.12013	2013
Metabolism	Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression.	Gangula P, Ravella K, Chukkapalli S, Rivera M, Srinivasan S, Hale A, Channon K, Southerland J, Kesavalu L.	PLoS One	10.1371/journal.pone.0129885	2015
	Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.	Chukkapalli SS, Ambadapadi S, Varkoly K, Jiron J, Aguirre JI, Bhattacharyya I, Morel LM, Lucas AR, Kesavalu L.	Pathog Dis	10.1093/femspd/fty076	2018
	Leaky Gum: The Revisited Origin of Systemic Diseases.	Park DY, Park JY, Lee D, Hwang I, Kim HS.	Cells	10.3390/cells11071079	2022
	Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components.	Nussbaum G, Ben-Adi S, Genzler T, Sela M, Rosen G.	Infect Immun	10.1128/iai.00488-09	2009
Metabolism	Treponema denticola alters cell vitality and induces HO-1 and Hsp70 expression in porcine aortic endothelial cells.	Bernardini C, Gaibani P, Zannoni A, Vocale C, Bacci ML, Piana G, Forni M, Sambri V.	Cell Stress Chaperones	10.1007/s12192-009-0164-3	2010
Pathogenicity	Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection.	Chukkapalli SS, Velsko IM, Rivera-Kweh MF, Larjava H, Lucas AR, Kesavalu L.	Mol Oral Microbiol	10.1111/omi.12165	2017
	The gain and loss of chromosomal integron systems in the Treponema species.	Wu YW, Doak TG, Ye Y.	BMC Evol Biol	10.1186/1471-2148-13-16	2013
Metabolism	Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities.	Cogoni V, Morgan-Smith A, Fenno JC, Jenkinson HF, Dymock D.	Microbiology (Reading)	10.1099/mic.0.055939-0	2012
Enzymology	Loop-mediated isothermal amplification method for rapid detection of the periodontopathic bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola.	Yoshida A, Nagashima S, Ansai T, Tachibana M, Kato H, Watari H, Notomi T, Takehara T.	J Clin Microbiol	10.1128/jcm.43.5.2418-2424.2005	2005
	Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease.	Kesavalu L, Sathishkumar S, Bakthavatchalu V, Matthews C, Dawson D, Steffen M, Ebersole JL.	Infect Immun	10.1128/iai.00733-06	2007
Genetics	Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease.	Endo A, Watanabe T, Ogata N, Nozawa T, Aikawa C, Arakawa S, Maruyama F, Izumi Y, Nakagawa I.	ISME J	10.1038/ismej.2014.155	2015
	Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease.	Verma RK, Rajapakse S, Meka A, Hamrick C, Pola S, Bhattacharyya I, Nair M, Wallet SM, Aukhil I, Kesavalu L.	Interdiscip Perspect Infect Dis	10.1155/2010/605125	2010
	Supernatants from oral epithelial cells and gingival fibroblasts modulate human immunodeficiency virus type 1 promoter activation induced by periodontopathogens in monocytes/macrophages.	Gonzalez OA, Ebersole JL, Huang CB.	Mol Oral Microbiol	10.1111/j.2041-1014.2009.00552.x	2010
	Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.	Chukkapalli SS, Velsko IM, Rivera-Kweh MF, Zheng D, Lucas AR, Kesavalu L.	PLoS One	10.1371/journal.pone.0143291	2015
Enzymology	Characterization of fibrinolytic activities of Treponema denticola.	Rosen G, Naor R, Kutner S, Sela MN.	Infect Immun	10.1128/iai.62.5.1749-1754.1994	1994
	Cloning and expression of two novel hemin binding protein genes from Treponema denticola.	Xu X, Holt SC, Kolodrubetz D.	Infect Immun	10.1128/iai.69.7.4465-4472.2001	2001
Pathogenicity	Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases.	Hao L, Chen J, Zhu Z, Reddy MS, Mountz JD, Chen W, Li YP.	J Periodontol	10.1902/jop.2015.140643	2015
	Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in alphavbeta6 integrin-deficient mice.	Velsko IM, Chukkapalli SS, Rivera-Kweh MF, Zheng D, Aukhil I, Lucas AR, Larjava H, Kesavalu L.	Infect Immun	10.1128/iai.01077-15	2015
Metabolism	Dentilisin activity affects the organization of the outer sheath of Treponema denticola.	Ishihara K, Kuramitsu HK, Miura T, Okuda K.	J Bacteriol	10.1128/jb.180.15.3837-3844.1998	1998
Metabolism	Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola.	Lai Y, Chu L.	Appl Environ Microbiol	10.1128/aem.01972-07	2008
	Virulence characteristics of oral treponemes in a murine model.	Kesavalu L, Walker SG, Holt SC, Crawley RR, Ebersole JL.	Infect Immun	10.1128/iai.65.12.5096-5102.1997	1997
	Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis.	Rivera MF, Chukkapalli SS, Velsko IM, Lee JY, Bhattacharyya I, Dolce C, Toro EJ, Holliday LS, Kesavalu L.	PLoS One	10.1371/journal.pone.0092119	2014
Metabolism	Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment.	Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC.	Infect Immun	10.1128/iai.68.4.1884-1892.2000	2000
Metabolism	Environmental modulation of oral treponeme virulence in a murine model.	Kesavalu L, Holt SC, Ebersole JL.	Infect Immun	10.1128/iai.67.6.2783-2789.1999	1999
	Lack of humoral immune protection against Treponema denticola virulence in a murine model.	Kesavalu L, Holt SC, Ebersole JL.	Infect Immun	10.1128/iai.67.11.5736-5746.1999	1999
	Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease.	Nahid MA, Rivera M, Lucas A, Chan EK, Kesavalu L.	Infect Immun	10.1128/iai.01062-10	2011
	Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice.	Rivera MF, Lee JY, Aneja M, Goswami V, Liu L, Velsko IM, Chukkapalli SS, Bhattacharyya I, Chen H, Lucas AR, Kesavalu LN.	PLoS One	10.1371/journal.pone.0057178	2013
Pathogenicity	Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola.	Roberts MC, Chung WO, Roe DE.	Antimicrob Agents Chemother	10.1128/aac.40.7.1690	1996
Metabolism	Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression.	Chu L, Dong Z, Xu X, Cochran DL, Ebersole JL.	Infect Immun	10.1128/iai.70.3.1113-1120.2002	2002
Pathogenicity	Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial.	Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Zaitsu T, Ohnuki M, Wright FA, Kawaguchi Y.	Trials	10.1186/1745-6215-11-14	2010
Enzymology	A major antigen on the outer envelope of a human oral spirochete, Treponema denticola.	Umemoto T, Namikawa I, Suido H, Asai S.	Infect Immun	10.1128/iai.57.8.2470-2474.1989	1989
Enzymology	Use of the genomic subtractive hybridization technique to develop a real-time PCR assay for quantitative detection of Prevotella spp. in oral biofilm samples.	Nagashima S, Yoshida A, Suzuki N, Ansai T, Takehara T.	J Clin Microbiol	10.1128/jcm.43.6.2948-2951.2005	2005
Metabolism	Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.	Hao L, Zhu G, Lu Y, Wang M, Jules J, Zhou X, Chen W.	FEBS Lett	10.1016/j.febslet.2015.04.008	2015
Enzymology	Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen.	Haapasalo M, Muller KH, Uitto VJ, Leung WK, Leung WK, McBride BC.	Infect Immun	10.1128/iai.60.5.2058-2065.1992	1992
	Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.	Chukkapalli S, Rivera-Kweh M, Gehlot P, Velsko I, Bhattacharyya I, Calise SJ, Satoh M, Chan EK, Holoshitz J, Kesavalu L.	Arthritis Res Ther	10.1186/s13075-016-1056-4	2016
Enzymology	Real-time TaqMan PCR for quantifying oral bacteria during biofilm formation.	Suzuki N, Nakano Y, Yoshida A, Yamashita Y, Kiyoura Y.	J Clin Microbiol	10.1128/jcm.42.8.3827-3830.2004	2004
Enzymology	Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST).	Boillot A, Demmer RT, Mallat Z, Sacco RL, Jacobs DR, Benessiano J, Tedgui A, Rundek T, Papapanou PN, Desvarieux M.	Atherosclerosis	10.1016/j.atherosclerosis.2015.07.039	2015
	Genome-wide association study of periodontal pathogen colonization.	Divaris K, Monda KL, North KE, Olshan AF, Lange EM, Moss K, Barros SP, Beck JD, Offenbacher S.	J Dent Res	10.1177/0022034512447951	2012
Enzymology	Development of a 5' fluorogenic nuclease-based real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.	Yoshida A, Suzuki N, Nakano Y, Oho T, Kawada M, Koga T.	J Clin Microbiol	10.1128/jcm.41.2.863-866.2003	2003
Enzymology	Identification, isolation, and characterization of the 42-kilodalton major outer membrane protein (MompA) from Treponema pectinovorum ATCC 33768.	Walker SG, Ebersole JL, Holt SC.	J Bacteriol	10.1128/jb.179.20.6441-6447.1997	1997
Phylogeny	Identification of seven Treponema species in health- and disease-associated dental plaque by nested PCR.	Willis SG, Smith KS, Dunn VL, Gapter LA, Riviere KH, Riviere GR.	J Clin Microbiol	10.1128/jcm.37.3.867-869.1999	1999
Metabolism	Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2.	Asai Y, Jinno T, Ogawa T.	Infect Immun	10.1128/iai.71.2.717-725.2003	2003
	Hemagglutination activity of Treponema denticola grown in serum-free medium in continuous culture.	Mikx FH, Keulers RA.	Infect Immun	10.1128/iai.60.5.1761-1766.1992	1992
	Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue.	Bakthavatchalu V, Meka A, Mans JJ, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Baker HV, Lamont RJ, Ebersole JL, Kesavalu L.	Mol Oral Microbiol	10.1111/j.2041-1014.2011.00619.x	2011
	Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola.	Egli C, Leung WK, Leung WK, Muller KH, Hancock RE, McBride BC.	Infect Immun	10.1128/iai.61.5.1694-1699.1993	1993
Enzymology	Cloning and expression of the aspartate carbamoyltransferase gene from Treponema denticola.	Ishihara K, Ishihara M, Takazoe I, Okuda K.	Appl Environ Microbiol	10.1128/aem.58.10.3399-3403.1992	1992
Metabolism	Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola.	Yang PF, Song M, Grove DA, Ellen RP.	Infect Immun	10.1128/iai.66.2.696-702.1998	1998
	Ceruloplasmin can substitute for rabbit serum in stimulating the growth of Treponema denticola.	Suzuki M, Loesche WJ.	Infect Immun	10.1128/iai.57.2.643-644.1989	1989
Pathogenicity	Changes in clinical and microbiological periodontal profiles relate to progression of carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology study.	Desvarieux M, Demmer RT, Jacobs DR, Papapanou PN, Sacco RL, Rundek T.	J Am Heart Assoc	10.1161/jaha.113.000254	2013
Enzymology	Detection and quantification of oral treponemes in subgingival plaque by real-time PCR.	Asai Y, Jinno T, Igarashi H, Ohyama Y, Ogawa T.	J Clin Microbiol	10.1128/jcm.40.9.3334-3340.2002	2002
Enzymology	Development of a 5' nuclease-based real-time PCR assay for quantitative detection of cariogenic dental pathogens Streptococcus mutans and Streptococcus sobrinus.	Yoshida A, Suzuki N, Nakano Y, Kawada M, Oho T, Koga T.	J Clin Microbiol	10.1128/jcm.41.9.4438-4441.2003	2003
	Pathogen-related oral spirochetes from dental plaque are invasive.	Riviere GR, Weisz KS, Adams DF, Thomas DD.	Infect Immun	10.1128/iai.59.10.3377-3380.1991	1991
	Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts.	Nixon CS, Steffen MJ, Ebersole JL.	Infect Immun	10.1128/iai.68.9.5284-5292.2000	2000
Enzymology	Quantitative immunoassay of Treponema denticola serovar C in adult periodontitis.	Simonson LG, Goodman CH, Morton HE.	J Clin Microbiol	10.1128/jcm.28.7.1493-1496.1990	1990
	Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium spp.	Kolenbrander PE, Parrish KD, Andersen RN, Greenberg EP.	Infect Immun	10.1128/iai.63.12.4584-4588.1995	1995
	Analysis of the IgG immune response to Treponema phagedenis-like spirochetes in individual dairy cattle with papillomatous digital dermatitis.	Moe KK, Yano T, Misumi K, Kubota C, Yamazaki W, Muguruma M, Misawa N.	Clin Vaccine Immunol	10.1128/cvi.00464-09	2010
Phylogeny	Phylogenetic characterization and prevalence of "Spirobacillus cienkowskii," a red-pigmented, spiral-shaped bacterial pathogen of freshwater Daphnia species.	Rodrigues JL, Duffy MA, Tessier AJ, Ebert D, Mouton L, Schmidt TM.	Appl Environ Microbiol	10.1128/aem.02438-07	2008
	Molecular cloning and sequence analysis of antigen gene tdpA of Treponema denticola.	Miyamoto M, Noji S, Kokeguchi S, Kato K, Kurihara H, Murayama Y, Taniguchi S.	Infect Immun	10.1128/iai.59.6.1941-1947.1991	1991
	Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.	Simonson LG, Rouse RF, Bockowski SW.	Infect Immun	10.1128/iai.56.1.60-63.1988	1988
	Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin).	Ishihara K, Miura T, Kuramitsu HK, Okuda K.	Infect Immun	10.1128/iai.64.12.5178-5186.1996	1996
Enzymology	Synthesis and secretion of phospholipase C by oral spirochetes.	Siboo R, al-Joburi W, Gornitsky M, Chan EC.	J Clin Microbiol	10.1128/jcm.27.3.568-570.1989	1989
Enzymology	Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis.	Riviere GR, Weisz KS, Simonson LG, Lukehart SA.	Infect Immun	10.1128/iai.59.8.2653-2657.1991	1991
Enzymology	Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis.	Gutner M, Chaushu S, Balter D, Bachrach G.	Infect Immun	10.1128/iai.00648-09	2009
Metabolism	Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola.	Fenno JC, Muller KH, McBride BC.	J Bacteriol	10.1128/jb.178.9.2489-2497.1996	1996
	Biochemical properties of the outer membrane of Treponema denticola.	Yotis WW, Sharma VK, Gopalsami C, Chegini S, McNulty J, Hoerman K, Keene J, Simonson LG.	J Clin Microbiol	10.1128/jcm.29.7.1397-1406.1991	1991
	Interaction of Treponema denticola TD-4, GM-1, and MS25 with human gingival fibroblasts.	Weinberg A, Holt SC.	Infect Immun	10.1128/iai.58.6.1720-1729.1990	1990
Metabolism	Subgingival bacterial colonization profiles correlate with gingival tissue gene expression.	Papapanou PN, Behle JH, Kebschull M, Celenti R, Wolf DL, Handfield M, Pavlidis P, Demmer RT.	BMC Microbiol	10.1186/1471-2180-9-221	2009
Phylogeny	Discrimination of Streptococcus pneumoniae from viridans group streptococci by genomic subtractive hybridization.	Suzuki N, Seki M, Nakano Y, Kiyoura Y, Maeno M, Yamashita Y.	J Clin Microbiol	10.1128/jcm.43.9.4528-4534.2005	2005
	Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.	Nahid MA, Yao B, Dominguez-Gutierrez PR, Kesavalu L, Satoh M, Chan EK.	J Immunol	10.4049/jimmunol.1103060	2013
	Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST).	Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR, Sacco RL, Papapanou PN.	Circulation	10.1161/01.cir.0000154582.37101.15	2005
Metabolism	Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.	Chukkapalli SS, Rivera MF, Velsko IM, Lee JY, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L	Infect Immun	10.1128/IAI.01511-14	2014
Pathogenicity	Salivary IgA subclasses and bacteria-reactive IgA in patients with aggressive periodontitis.	Hagewald S, Bernimoulin JP, Kottgen E, Kage A	J Periodontal Res	10.1034/j.1600-0765.2002.00337.x	2002
Pathogenicity	Chemotaxis of oral treponemes toward sera and albumin of rabbit.	Umemoto T, Jinno T, Taiji Y, Ogawa T	Microbiol Immunol	10.1111/j.1348-0421.2001.tb01288.x	2001
Enzymology	Multiple forms of the major phenylalanine specific protease in Treponema denticola.	Rosen G, Naor R, Sela MN	J Periodontal Res	10.1111/j.1600-0765.1999.tb02253.x	1999
Pathogenicity	Studies on the binding of Treponema pectinovorum to HEp-2 epithelial cells.	Walker SG, Ebersole JL, Holt SC	Oral Microbiol Immunol	10.1034/j.1399-302x.1999.140304.x	1999
Enzymology	Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization.	Chu L, Ebersole JL, Kurzban GP, Holt SC	Clin Infect Dis	10.1086/515164	1999
Pathogenicity	Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola.	Rosen G, Sela MN, Naor R, Halabi A, Barak V, Shapira L	Infect Immun	10.1128/IAI.67.3.1180-1186.1999	1999
Enzymology	Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola, with hemolytic and hemoxidative activities.	Chu L, Ebersole JL, Kurzban GP, Holt SC	Infect Immun	10.1128/iai.65.8.3231-3238.1997	1997
Pathogenicity	Lipoproteins of Treponema denticola: their effect on human polymorphonuclear neutrophils.	Sela MN, Bolotin A, Naor R, Weinberg A, Rosen G	J Periodontal Res	10.1111/j.1600-0765.1997.tb00558.x	1997
Pathogenicity	Proteases of Treponema denticola outer sheath and extracellular vesicles.	Rosen G, Naor R, Rahamim E, Yishai R, Sela MN	Infect Immun	10.1128/iai.63.10.3973-3979.1995	1995
Pathogenicity	Coaggregation between Porphyromonas gingivalis and Treponema denticola.	Onagawa M, Ishihara K, Okuda K	Bull Tokyo Dent Coll		1994
Enzymology	Cloning and expression of hemolysin genes from Treponema denticola strains ATCC 35404 (TD-4) and human clinical isolate GM-1 in Escherichia coli.	Karunakaran T, Holt SC	Microb Pathog	10.1006/mpat.1994.1034	1994
Enzymology	Purification and characterization of a 45 kDa hemolysin from Treponema denticola ATCC 35404.	Chu L, Holt SC	Microb Pathog	10.1006/mpat.1994.1020	1994
Pathogenicity	Characterization of hemolysis and hemoxidation activities by Treponema denticola.	Chu L, Kennell W, Holt SC	Microb Pathog	10.1006/mpat.1994.1019	1994
Pathogenicity	Common and specific antigens of several treponemes detected by polyclonal antisera against major cellular proteins.	Nakamura Y, Umemoto T, Nakatani Y, Namikawa I, Wadood A	Oral Microbiol Immunol	10.1111/j.1399-302x.1993.tb00576.x	1993
Enzymology	Antigenic behaviors of two axial flagellar proteins detected in Treponema denticola.	Umemoto T, Wadood A, Nakamura Y, Nakatani Y, Namikawa I	Microbiol Immunol	10.1111/j.1348-0421.1993.tb03194.x	1993
Metabolism	Chemical and biological activities of a 64-kilodalton outer sheath protein from Treponema denticola strains.	Weinberg A, Holt SC	J Bacteriol	10.1128/jb.173.21.6935-6947.1991	1991
Metabolism	Comparative analysis of motility and other properties of Treponema denticola strains.	Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F	Microb Pathog	10.1016/j.micpath.2016.11.021	2016
Phylogeny	Mitogenic activity of the outer membrane of Treponema denticola.	Schade SZ, Yotis WW, Gopalsami C, Simonson LG	Microbios		1998
Genetics	Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.	Fenno JC, Wong GW, Hannam PM, Muller KH, Leung WK, McBride BC	J Bacteriol	10.1128/jb.179.4.1082-1089.1997	1997
Enzymology	Enzyme profiles of oral spirochetes in RapID-ANA system.	Syed SA, Salvador SL, Loesche WJ	J Clin Microbiol	10.1128/jcm.26.10.2226-2228.1988	1988
Phylogeny	Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets.	Chan EC, Siboo R, Keng T, Psarra N, Hurley R, Cheng SL, Iugovaz I	Int J Syst Bacteriol	10.1099/00207713-43-2-196	1993

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Treponema denticola (JCM 8152, ATCC 35404, CIP 103920)

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