Name: Neisseria meningitidis FAM18
Creator: BacDive
License: https://creativecommons.org/licenses/by/4.0/

Strain identifier

BacDive ID: 10474

Type strain:

Species: Neisseria meningitidis

Strain Designation: FAM18

Culture col. no.: DSM 15464

Strain history: <- M. Achtman; FAM18 <- J. G. Cannon

NCBI tax ID(s): 487 (species)

SI-ID 113595

DSM 15464

Special Collections

DSMZ

Other strains from Neisseria meningitidis

Section

Neisseria meningitidis FAM18 is a microaerophile, Gram-negative bacterium that was isolated from cerebrospinal fluid.

Gram-negative
microaerophile
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Pseudomonadota*
	Class	*Betaproteobacteria*
	Order	*Neisseriales*
	Family	*Neisseriaceae*
	Genus	*Neisseria*
	Species	**Neisseria meningitidis**
	Full Scientific Name (LPSN)	Neisseria meningitidis (Albrecht and Ghon 1901) Murray 1929 (Approved Lists 1980)

Synonym

"Micrococcus meningitidis"

Information on morphological and physiological properties Morphology

[Ref.: #69480]	Gram stain	negative Confidence in %99.5

[Ref.: #5939]	Type of hemolysis	gamma
[Ref.: #5939]	Incubation period	1-2 days

Information on culture and growth conditions Culture and growth conditions

[Ref.: #5939]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #5939]

Culture medium growth

[Ref.: #5939]

Culture medium link

Medium recipe at MediaDive

[Ref.: #5939]

Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #5939]			growth	37 °C

Information on physiology and metabolism Physiology and metabolism

[Ref.: #5939]

Oxygen tolerance

microaerophile

[Ref.: #69480]

Ability of spore formation

no Confidence in %92.95

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68377]	ornithine ChEBI	-	degradation	* from API NH
[Ref.: #68377]	sucrose ChEBI	-	builds acid from	* from API NH
[Ref.: #68377]	tryptophan ChEBI	-	energy source	* from API NH
[Ref.: #68377]	urea ChEBI	-	hydrolysis	* from API NH

	Metabolite production	Metabolite	Production
[Ref.: #68377]		indole ChEBI	no	* from API NH

	Physiological tests	Metabolite	Indole test
[Ref.: #68377]		indole ChEBI	-	* from API NH

	Enzyme	Enzyme activity	EC number
[Ref.: #68377]	alkaline phosphatase	-	3.1.3.1	* from API NH
[Ref.: #5939]	catalase	+	1.11.1.6
[Ref.: #5939]	cytochrome-c oxidase	+	1.9.3.1
[Ref.: #68377]	lipase	-		* from API NH
[Ref.: #68377]	ornithine decarboxylase	-	4.1.1.17	* from API NH
[Ref.: #68377]	tryptophan deaminase	-	4.1.99.1	* from API NH
[Ref.: #68377]	urease	-	3.5.1.5	* from API NH

API® NH:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Penicillinase productionPEN	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from maltoseMAL	Acid from sucroseSAC	Ornithine decarboxylaseODC	Urease/urea hydrolysisURE	LipaseLIP	Alkaline phosphatasePAL	beta-Galactosidasebeta GAL	Proline arylamidaseProA	gamma-Glutamyl transferaseGGT	Indole productionIND
[Ref.: #5939]	6079	+	-	+/-	-	-	-	-	-	-	+/-	+/-	-	-
[Ref.: #5939]	5795	-	+	-	+/-	-	-	-	-	-	-	+/-	+/-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #5939]	Sample type/isolated from	cerebrospinal fluid
[Ref.: #5939]	Geographic location (country and/or sea, region)	North Carolina
[Ref.: #5939]	Country	USA
[Ref.: #5939]	Country ISO 3 Code	USA
[Ref.: #5939]	Continent	North America
* marker position based on {}

Isolation sources categories

#Host Body Product	#Fluids	#Cerebrospinal fluid
#Infection	#Patient	-

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #5939]

Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Neisseria meningitidis FAM18	GCA_000009465	complete	GenBank ENA	272831 tax ID	*
[Ref.: #66792]	Neisseria meningitidis FAM18	272831.7	complete	PATRIC	272831 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Model	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Neisseria meningitidis FAM18 FAM18 NCBI: GCA_000009465.1
[Ref.: #69480]	gram-positive	gram-positiveⓘ	no	99.5	no
[Ref.: #69480]	anaerobic	anaerobicⓘ	no	95.417	yes
[Ref.: #69480]	aerobic	aerobicⓘ	no	62.06	yes
[Ref.: #69480]	spore-forming	spore-formingⓘ	no	92.95	no
[Ref.: #69480]	thermophilic	thermophileⓘ	no	98	yes
[Ref.: #69480]	flagellated	motile2+ⓘ	no	86.416	no

Availability in culture collections External links

[Ref.: #5939]

Culture collection no.

DSM 15464

[Ref.: #79751]

SI-ID 113595

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Characterization of Vsr endonucleases from Neisseria meningitidis.	Bazlekowa M, Adamczyk-Poplawska M, Kwiatek A	Microbiology (Reading)	10.1099/mic.0.000492	2017	*
Genetics	Insight into proteomic investigations of Neisseria meningitidis serogroup C strain L91543 from analysis of its genome sequence.	Karlyshev AV, Snyder LA, McFadden J, Griffin R	FEMS Microbiol Lett	10.1093/femsle/fnv055	2015	*
Phylogeny	The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species.	Davies JK, Harrison PF, Lin YH, Bartley S, Khoo CA, Seemann T, Ryan CS, Kahler CM, Hill SA	PLoS One	10.1371/journal.pone.0086704	2014	*
Genetics	Draft genome sequences of two Neisseria meningitidis serogroup C clinical isolates.	Lavezzo E, Toppo S, Barzon L, Cobelli C, Di Camillo B, Finotello F, Franchin E, Peruzzo D, Toffolo GM, Trevisan M, Palu G	J Bacteriol	10.1128/JB.00789-10	2010	*
Phylogeny	Bacteriocins (meningocins) in Norwegian isolates of Neisseria meningitidis: possible role in the course of a meningococcal epidemic.	Allunans J, Kristiansen KI, Assalkhou R, Bjoras M	APMIS	10.1111/j.1600-0463.2008.00850.x	2008	*
Phylogeny	Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species.	Harrison OB, Maiden MC, Rokbi B	BMC Microbiol	10.1186/1471-2180-8-66	2008	*
Pathogenicity	Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.	Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ, Parkhill J	PLoS Genet	10.1371/journal.pgen.0030023	2006	*
Genetics	Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.	Hotopp JCD, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H	Microbiology (Reading)	10.1099/mic.0.29261-0	2006	*
Phylogeny	Use of a multilocus variable-number tandem repeat analysis method for molecular subtyping and phylogenetic analysis of Neisseria meningitidis isolates.	Liao JC, Li CC, Chiou CS	BMC Microbiol	10.1186/1471-2180-6-44	2006	*
Pathogenicity	Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.	Turner DP, Marietou AG, Johnston L, Ho KK, Rogers AJ, Wooldridge KG, Ala'Aldeen DA	Infect Immun	10.1128/IAI.74.5.2957-2964.2006	2006	*
Genetics	Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.	Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J	Microbiology (Reading)	10.1099/mic.0.28099-0	2005	*
Metabolism	Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis.	Power PM, Roddam LF, Rutter K, Fitzpatrick SZ, Srikhanta YN, Jennings MP	Mol Microbiol	10.1046/j.1365-2958.2003.03602.x	2003	*
Enzymology	Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical origins.	Hobbs MM, Malorny B, Prasad P, Morelli G, Kusecek B, Heckels JE, Cannon JG, Achtman M	Microbiology (Reading)	10.1099/00221287-144-1-157	1998	*
Genetics	Characterization of a class II pilin expression locus from Neisseria meningitidis: evidence for increased diversity among pilin genes in pathogenic Neisseria species.	Aho EL, Botten JW, Hall RJ, Larson MK, Ness JK	Infect Immun	10.1128/iai.65.7.2613-2620.1997	1997	*
Enzymology	Characterization of the opa (class 5) gene family of Neisseria meningitidis.	Aho EL, Dempsey JA, Hobbs MM, Klapper DG, Cannon JG	Mol Microbiol	10.1111/j.1365-2958.1991.tb00789.x	1991	*
Enzymology	Characterization of a silent pilin gene locus from Neisseria meningitidis strain FAM18.	Aho EL, Cannon JG	Microb Pathog	10.1016/0882-4010(88)90039-3	1988	*
Genetics	Reversible phase variation of expression of Neisseria meningitidis class 5 outer membrane proteins and their relationship to gonococcal proteins II.	Kawula TH, Aho EL, Barritt DS, Klapper DG, Cannon JG	Infect Immun	10.1128/iai.56.2.380-386.1988	1988	*
	Frequency and rate of pilin antigenic variation of Neisseria meningitidis.	Helm RA, Seifert HS	J Bacteriol	10.1128/JB.00280-10	2010	*

References

#5939

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 15464

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68377

Automatically annotated from API NH .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#79751

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID113595.1 )

* These data were automatically processed and therefore are not curated

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