Name: Neisseria meningitidis Z2491
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 10475

Type strain:

Species: Neisseria meningitidis

Strain Designation: Z2491

Culture col. no.: DSM 15465

Strain history: <- M. Achtman; Z2491 <- R. A. Wall

NCBI tax ID(s): 487 (species)

SI-ID 113596

DSM 15465

Other strains from Neisseria meningitidis

Section

Neisseria meningitidis Z2491 is a microaerophile, mesophilic bacterium that was isolated from cerebrospinal fluid.

mesophilic
microaerophile
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Pseudomonadota*
	Class	*Betaproteobacteria*
	Order	*Neisseriales*
	Family	*Neisseriaceae*
	Genus	*Neisseria*
	Species	**Neisseria meningitidis**
	Full Scientific Name (LPSN)	Neisseria meningitidis (Albrecht and Ghon 1901) Murray 1929 (Approved Lists 1980)

Synonym

"Micrococcus meningitidis"

Information on culture and growth conditions Culture and growth conditions

[Ref.: #5940]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #5940]

Culture medium growth

[Ref.: #5940]

Culture medium link

Medium recipe at MediaDive

[Ref.: #5940]

Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #5940]			growth	37 °C

[Ref.: #5940]

Temperature range

mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #5940]

Oxygen tolerance

microaerophile

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68377]	ornithine ChEBI	-	degradation	* from API NH
[Ref.: #68377]	sucrose ChEBI	-	builds acid from	* from API NH
[Ref.: #68377]	tryptophan ChEBI	-	energy source	* from API NH
[Ref.: #68377]	urea ChEBI	-	hydrolysis	* from API NH

	Metabolite production	Metabolite	Production
[Ref.: #68377]		indole ChEBI	no	* from API NH

	Physiological tests	Metabolite	Indole test
[Ref.: #68377]		indole ChEBI	-	* from API NH

	Enzyme	Enzyme activity	EC number
[Ref.: #68377]	alkaline phosphatase	-	3.1.3.1	* from API NH
[Ref.: #68377]	beta-galactosidase	-	3.2.1.23	* from API NH
[Ref.: #68377]	lipase	-		* from API NH
[Ref.: #68377]	ornithine decarboxylase	-	4.1.1.17	* from API NH
[Ref.: #68377]	tryptophan deaminase	-	4.1.99.1	* from API NH
[Ref.: #68377]	urease	-	3.5.1.5	* from API NH

API® NH:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Penicillinase productionPEN	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from maltoseMAL	Acid from sucroseSAC	Ornithine decarboxylaseODC	Urease/urea hydrolysisURE	LipaseLIP	Alkaline phosphatasePAL	beta-Galactosidasebeta GAL	Proline arylamidaseProA	gamma-Glutamyl transferaseGGT	Indole productionIND
[Ref.: #5940]	6078	+	-	+	-	-	-	-	-	-	-	+	-	-
[Ref.: #5940]	5925	-	+	-	+/-	-	-	-	-	-	-	-	+	-
[Ref.: #5940]	5794	-	+	-	+	-	-	-	-	-	-	-	+	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #5940]	Sample type/isolated from	cerebrospinal fluid
[Ref.: #5940]	Country	Gambia
[Ref.: #5940]	Country ISO 3 Code	GMB
[Ref.: #5940]	Continent	Africa
* marker position based on {}

Isolation sources categories

#Host Body Product	#Fluids	#Cerebrospinal fluid
#Infection	#Patient	-

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #5940]

Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Neisseria meningitidis Z2491	GCA_000009105	complete	GenBank	122587 tax ID	*
[Ref.: #66792]	Neisseria meningitidis Z2491	122587.5	complete	PATRIC	122587 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Neisseria meningitidis Z2491 Z2491 NCBI: GCA_000009105.1
[Ref.: #69480]	motile	no	84.355	no
[Ref.: #69480]	flagellated	no	91.17	no
[Ref.: #69480]	gram-positive	no	98.401	no
[Ref.: #69480]	anaerobic	no	97.768	yes
[Ref.: #69480]	halophile	no	62.353	no
[Ref.: #69480]	spore-forming	no	97.348	no
[Ref.: #69480]	thermophile	no	98.948	yes
[Ref.: #69480]	glucose-util	yes	64.547	no
[Ref.: #69480]	aerobic	no	93.494	yes
[Ref.: #69480]	glucose-ferment	no	89.987	no

Availability in culture collections External links

[Ref.: #5940]

Culture collection no.

DSM 15465

[Ref.: #79752]

SI-ID 113596

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Comparative sequence- and structure-inspired drug design for PilF protein of Neisseria meningitidis.	Mehta AS, Snigdha K, Potukuchi MS, Tsonis PA	Hum Genomics	10.1186/s40246-015-0027-1	2015	*
Metabolism	Novel non-specific DNA adenine methyltransferases.	Drozdz M, Piekarowicz A, Bujnicki JM, Radlinska M	Nucleic Acids Res	10.1093/nar/gkr1039	2011	*
Genetics	Genotypic and phenotypic modifications of Neisseria meningitidis after an accidental human passage.	Omer H, Rose G, Jolley KA, Frapy E, Zahar JR, Maiden MC, Bentley SD, Tinsley CR, Nassif X, Bille E	PLoS One	10.1371/journal.pone.0017145	2011	*
Genetics	A novel interpretation of structural dot plots of genomes derived from the analysis of two strains of Neisseria meningitidis.	Cuff WR, Duvvuri VR, Liang B, Duvvuri B, Wu GE, Wu J, Tsang RS	Genomics Proteomics Bioinformatics	10.1016/S1672-0229(10)60018-6	2010	*
Enzymology	The structure of the L9 immunotype lipooligosaccharide from Neisseria meningitidis NMA Z2491.	Choudhury B, Kahler CM, Datta A, Stephens DS, Carlson RW	Carbohydr Res	10.1016/j.carres.2008.08.026	2008	*
Enzymology	Cloning, gene expression and characterization of a novel bacterial NAD-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Neisseria meningitidis strain Z2491.	Fourrat L, Iddar A, Valverde F, Serrano A, Soukri A	Mol Cell Biochem	10.1007/s11010-007-9545-z	2007	*
Genetics	Bacterial repetitive extragenic palindromic sequences are DNA targets for Insertion Sequence elements.	Tobes R, Pareja E	BMC Genomics	10.1186/1471-2164-7-62	2006	*
Genetics	An in vitro strategy for the selective isolation of anomalous DNA from prokaryotic genomes.	van Passel MW, Bart A, Waaijer RJ, Luyf AC, van Kampen AH, van der Ende A	Nucleic Acids Res	10.1093/nar/gnh115	2004	*
Pathogenicity	The REP2 repeats of the genome of Neisseria meningitidis are associated with genes coordinately regulated during bacterial cell interaction.	Morelle S, Carbonnelle E, Nassif X	J Bacteriol	10.1128/JB.185.8.2618-2627.2003	2003	*
Genetics	Genome analysis and strain comparison of correia repeats and correia repeat-enclosed elements in pathogenic Neisseria.	Liu SV, Saunders NJ, Jeffries A, Rest RF	J Bacteriol	10.1128/JB.184.22.6163-6173.2002	2002	*
Metabolism	In vivo expression of Neisseria meningitidis proteins homologous to the Haemophilus influenzae Hap and Hia autotransporters.	van Ulsen P, van Alphen L, Hopman CT, van der Ende A, Tommassen J	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.2001.tb00534.x	2001	*
Genetics	Whole-genome organization and functional properties of miniature DNA insertion sequences conserved in pathogenic Neisseriae.	Mazzone M, De Gregorio E, Lavitola A, Pagliarulo C, Alifano P, Di Nocera PP	Gene	10.1016/s0378-1119(01)00725-9	2001	*
Genetics	Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp.	Snyder LAS, Butcher SA, Saunders NJ	Microbiology (Reading)	10.1099/00221287-147-8-2321	2001	*
Genetics	Short interrupted palindromes on the extragenic DNA of Escherichia coli K-12, Haemophilus influenzae and Neisseria meningitidis.	Vasconcelos AT, Maia MA, de Almeida DF	Bioinformatics	10.1093/bioinformatics/16.11.968	2000	*
Genetics	Finding pathogenicity islands and gene transfer events in genome data.	Lio P, Vannucci M	Bioinformatics	10.1093/bioinformatics/16.10.932	2000	*
Enzymology	Genomic rearrangements in neisseria meningitidis strains of the ET-5 complex.	Froholm LO, Kolsto AB, Berner JM, Caugant DA	Curr Microbiol	10.1007/s002840010073	2000	*
Genetics	Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.	Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, Morelli G, Basham D, Brown D, Chillingworth T, Davies RM, Davis P, Devlin K, Feltwell T, Hamlin N, Holroyd S, Jagels K, Leather S, Moule S, Mungall K, Quail MA, Rajandream MA, Rutherford KM, Simmonds M, Skelton J, Whitehead S, Spratt BG, Barrell BG	Nature	10.1038/35006655	2000	*
Metabolism	Phosphorylcholine decoration of lipopolysaccharide differentiates commensal Neisseriae from pathogenic strains: identification of licA-type genes in commensal Neisseriae.	Serino L, Virji M	Mol Microbiol	10.1046/j.1365-2958.2000.01825.x	2000	*
Enzymology	Analysis of the genetic differences between Neisseria meningitidis and Neisseria gonorrhoeae: two closely related bacteria expressing two different pathogenicities.	Tinsley CR, Nassif X	Proc Natl Acad Sci U S A	10.1073/pnas.93.20.11109	1996	*
Enzymology	The physical map of the chromosome of a serogroup A strain of Neisseria meningitidis shows complex rearrangements relative to the chromosomes of the two mapped strains of the closely related species N. gonorrhoeae.	Dempsey JA, Wallace AB, Cannon JG	J Bacteriol	10.1128/jb.177.22.6390-6400.1995	1995	*
Pathogenicity	Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.	Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ, Parkhill J	PLoS Genet	10.1371/journal.pgen.0030023	2006	*
Genetics	Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.	Hotopp JCD, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H	Microbiology (Reading)	10.1099/mic.0.29261-0	2006	*
Phylogeny	Use of a multilocus variable-number tandem repeat analysis method for molecular subtyping and phylogenetic analysis of Neisseria meningitidis isolates.	Liao JC, Li CC, Chiou CS	BMC Microbiol	10.1186/1471-2180-6-44	2006	*
Pathogenicity	Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.	Turner DP, Marietou AG, Johnston L, Ho KK, Rogers AJ, Wooldridge KG, Ala'Aldeen DA	Infect Immun	10.1128/IAI.74.5.2957-2964.2006	2006	*
Genetics	Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.	Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J	Microbiology (Reading)	10.1099/mic.0.28099-0	2005	*
Metabolism	Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis.	Power PM, Roddam LF, Rutter K, Fitzpatrick SZ, Srikhanta YN, Jennings MP	Mol Microbiol	10.1046/j.1365-2958.2003.03602.x	2003	*
	Direct detection and serogroup characterization of Neisseria meningitidis from outbreak of meningococcal meningitis in Delhi.	Negi S, Grover S, Rautela S, Rawat D, Gupta S, Khare S, Lal S, Rai A	Iran J Microbiol		2010	*
	Genome sequencing and annotation.	Jeffries AC, Saunders NJ, Hood DW	Methods Mol Med	10.1385/1-59259-149-3:215	2001	*
	Identification of regions of the chromosome of Neisseria meningitidis and Neisseria gonorrhoeae which are specific to the pathogenic Neisseria species.	Perrin A, Nassif X, Tinsley C	Infect Immun	10.1128/IAI.67.11.6119-6129.1999	1999	*

References

#5940

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 15465

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68377

Automatically annotated from API NH .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#79752

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID113596.1 )

* These data were automatically processed and therefore are not curated

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Neisseria meningitidis Z2491 Z2491

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