Strain identifier
BacDive ID: 10474
Type strain:
Species: Neisseria meningitidis
Strain Designation: FAM18
Strain history: <- M. Achtman; FAM18 <- J. G. Cannon
NCBI tax ID(s): 487 (species)
General
@ref: 5939
BacDive-ID: 10474
DSM-Number: 15464
keywords: genome sequence, Bacteria, microaerophile, mesophilic
description: Neisseria meningitidis FAM18 is a microaerophile, mesophilic bacterium that was isolated from cerebrospinal fluid.
NCBI tax id
- NCBI tax id: 487
- Matching level: species
strain history
- @ref: 5939
- history: <- M. Achtman; FAM18 <- J. G. Cannon
doi: 10.13145/bacdive10474.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/pseudomonadota
- domain: Bacteria
- phylum: Pseudomonadota
- class: Betaproteobacteria
- order: Neisseriales
- family: Neisseriaceae
- genus: Neisseria
- species: Neisseria meningitidis
- full scientific name: Neisseria meningitidis (Albrecht and Ghon 1901) Murray 1929 (Approved Lists 1980)
synonyms
- @ref: 20215
- synonym: Micrococcus meningitidis
@ref: 5939
domain: Bacteria
phylum: Proteobacteria
class: Betaproteobacteria
order: Neisseriales
family: Neisseriaceae
genus: Neisseria
species: Neisseria meningitidis
full scientific name: Neisseria meningitidis (Albrecht and Ghon 1901) Murray 1929
strain designation: FAM18
type strain: no
Morphology
colony morphology
- @ref: 5939
- type of hemolysis: gamma
- incubation period: 1-2 days
Culture and growth conditions
culture medium
- @ref: 5939
- name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)
- growth: yes
- link: https://mediadive.dsmz.de/medium/693
- composition: Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
culture temp
- @ref: 5939
- growth: positive
- type: growth
- temperature: 37
- range: mesophilic
Physiology and metabolism
oxygen tolerance
- @ref: 5939
- oxygen tolerance: microaerophile
metabolite utilization
@ref | Chebi-ID | metabolite | utilization activity | kind of utilization tested |
---|---|---|---|---|
68377 | 17992 | sucrose | - | builds acid from |
68377 | 18257 | ornithine | - | degradation |
68377 | 16199 | urea | - | hydrolysis |
68377 | 27897 | tryptophan | - | energy source |
metabolite production
- @ref: 68377
- Chebi-ID: 35581
- metabolite: indole
- production: no
metabolite tests
- @ref: 68377
- Chebi-ID: 35581
- metabolite: indole
- indole test: -
enzymes
@ref | value | activity | ec |
---|---|---|---|
5939 | catalase | + | 1.11.1.6 |
5939 | cytochrome-c oxidase | + | 1.9.3.1 |
68377 | tryptophan deaminase | - | 4.1.99.1 |
68377 | alkaline phosphatase | - | 3.1.3.1 |
68377 | lipase | - | |
68377 | urease | - | 3.5.1.5 |
68377 | ornithine decarboxylase | - | 4.1.1.17 |
API NH
@ref | PEN | GLU | FRU | MAL | SAC | ODC | URE | LIP | PAL | beta GAL | ProA | GGT | IND |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5939 | + | - | +/- | - | - | - | - | - | - | +/- | +/- | - | - |
5939 | - | + | - | +/- | - | - | - | - | - | - | +/- | +/- | - |
Isolation, sampling and environmental information
isolation
- @ref: 5939
- sample type: cerebrospinal fluid
- geographic location: North Carolina
- country: USA
- origin.country: USA
- continent: North America
isolation source categories
Cat1 | Cat2 | Cat3 |
---|---|---|
#Host Body Product | #Fluids | #Cerebrospinal fluid |
#Infection | #Patient |
Safety information
risk assessment
- @ref: 5939
- biosafety level: 2
- biosafety level comment: Risk group (German classification)
Sequence information
Genome sequences
@ref | description | accession | assembly level | database | NCBI tax ID |
---|---|---|---|---|---|
66792 | Neisseria meningitidis FAM18 | GCA_000009465 | complete | ncbi | 272831 |
66792 | Neisseria meningitidis FAM18 | 272831.7 | complete | patric | 272831 |
Genome-based predictions
predictions
trait | prediction | confidence | training_data |
---|---|---|---|
motile | no | 84.307 | no |
flagellated | no | 89.949 | no |
gram-positive | no | 98.497 | no |
anaerobic | no | 98.189 | yes |
halophile | no | 62.501 | no |
spore-forming | no | 97.262 | no |
thermophile | no | 99.074 | no |
glucose-util | yes | 64.696 | no |
aerobic | no | 94.074 | yes |
glucose-ferment | no | 89.497 | no |
External links
@ref: 5939
culture collection no.: DSM 15464
straininfo link
- @ref: 79751
- straininfo: 113595
literature
topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
---|---|---|---|---|---|---|---|---|
Enzymology | 1787795 | Characterization of the opa (class 5) gene family of Neisseria meningitidis. | Aho EL, Dempsey JA, Hobbs MM, Klapper DG, Cannon JG | Mol Microbiol | 10.1111/j.1365-2958.1991.tb00789.x | 1991 | Amino Acid Sequence, Antigenic Variation/genetics, Antigens, Bacterial/*genetics, Bacterial Outer Membrane Proteins/*genetics/immunology, Base Sequence, Blotting, Southern, Cloning, Molecular, Electrophoresis, Gel, Pulsed-Field, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data, Multigene Family/*genetics, Neisseria meningitidis/*genetics | Genetics |
Genetics | 3123389 | Reversible phase variation of expression of Neisseria meningitidis class 5 outer membrane proteins and their relationship to gonococcal proteins II. | Kawula TH, Aho EL, Barritt DS, Klapper DG, Cannon JG | Infect Immun | 10.1128/iai.56.2.380-386.1988 | 1988 | Amino Acid Sequence, Antibodies, Bacterial/immunology, Antibodies, Monoclonal, Antigenic Variation, Antigens, Bacterial/genetics, Bacterial Outer Membrane Proteins/genetics/*immunology, Base Sequence, DNA, Bacterial/genetics, Gene Expression Regulation, Genes, Bacterial, Molecular Sequence Data, Neisseria gonorrhoeae/genetics/*immunology, Neisseria meningitidis/genetics/*immunology | |
Enzymology | 3148818 | Characterization of a silent pilin gene locus from Neisseria meningitidis strain FAM18. | Aho EL, Cannon JG | Microb Pathog | 10.1016/0882-4010(88)90039-3 | 1988 | Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics, Base Sequence, Blotting, Southern, Chromosome Mapping, Chromosomes, Bacterial, Cloning, Molecular, DNA, Bacterial/genetics/isolation & purification, Fimbriae Proteins, *Genes, *Genes, Bacterial, Genetic Variation, Molecular Sequence Data, Neisseria meningitidis/*genetics, Restriction Mapping | Genetics |
Genetics | 9199428 | Characterization of a class II pilin expression locus from Neisseria meningitidis: evidence for increased diversity among pilin genes in pathogenic Neisseria species. | Aho EL, Botten JW, Hall RJ, Larson MK, Ness JK | Infect Immun | 10.1128/iai.65.7.2613-2620.1997 | 1997 | Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics, Base Sequence, Fimbriae Proteins, Genetic Variation, Molecular Sequence Data, Neisseria meningitidis/*genetics | |
Enzymology | 9467908 | Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical origins. | Hobbs MM, Malorny B, Prasad P, Morelli G, Kusecek B, Heckels JE, Cannon JG, Achtman M | Microbiology (Reading) | 10.1099/00221287-144-1-157 | 1998 | Amino Acid Sequence, Antigens, Bacterial/biosynthesis/chemistry/*genetics, Bacterial Outer Membrane Proteins/genetics, Cloning, Molecular, Genes, Bacterial, Geography, Humans, Mali, Molecular Sequence Data, Neisseria meningitidis/classification/*genetics/isolation & purification, Recombinant Proteins/biosynthesis/chemistry, *Recombination, Genetic, Sequence Alignment, Sequence Homology, Amino Acid, Serotyping, United States | Pathogenicity |
Metabolism | 12864863 | Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis. | Power PM, Roddam LF, Rutter K, Fitzpatrick SZ, Srikhanta YN, Jennings MP | Mol Microbiol | 10.1046/j.1365-2958.2003.03602.x | 2003 | Amino Acid Sequence, Bacterial Proteins/*genetics/physiology, Base Sequence, Carbohydrate Sequence, Fimbriae Proteins/*metabolism, Fimbriae, Bacterial/*metabolism, *Genes, Bacterial, Molecular Sequence Data, Neisseria meningitidis/*genetics/metabolism/pathogenicity, Oligosaccharides/metabolism, Open Reading Frames/genetics, Phosphorylation, Polymorphism, Genetic, *Protein Processing, Post-Translational, Sequence Alignment, Sequence Homology, Virulence | Genetics |
Genetics | 16151203 | Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. | Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J | Microbiology (Reading) | 10.1099/mic.0.28099-0 | 2005 | Antigens, Bacterial/*genetics, *Genome, Bacterial, Neisseria/classification/*genetics/pathogenicity, *Oligonucleotide Array Sequence Analysis, Virulence/genetics | Phylogeny |
Pathogenicity | 16622234 | Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis. | Turner DP, Marietou AG, Johnston L, Ho KK, Rogers AJ, Wooldridge KG, Ala'Aldeen DA | Infect Immun | 10.1128/IAI.74.5.2957-2964.2006 | 2006 | Animals, Antibodies, Bacterial/immunology, *Bacterial Adhesion, Bacterial Proteins/*physiology, Blood Bactericidal Activity, Endothelial Cells/*microbiology, Epithelial Cells/microbiology, Escherichia coli/physiology, Humans, Membrane Proteins/genetics/immunology/*physiology, Neisseria meningitidis/*physiology, Rabbits | |
Phylogeny | 16686962 | Use of a multilocus variable-number tandem repeat analysis method for molecular subtyping and phylogenetic analysis of Neisseria meningitidis isolates. | Liao JC, Li CC, Chiou CS | BMC Microbiol | 10.1186/1471-2180-6-44 | 2006 | *Bacterial Typing Techniques, DNA, Bacterial/chemistry, Genotype, Humans, Neisseria meningitidis/*classification/genetics/isolation & purification, *Phylogeny, Tandem Repeat Sequences | Genetics |
Genetics | 17159225 | Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes. | Hotopp JCD, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H | Microbiology (Reading) | 10.1099/mic.0.29261-0 | 2006 | Bacterial Capsules/genetics, Biological Transport/genetics, Cluster Analysis, DNA Transposable Elements, *Gene Transfer, Horizontal, *Genome, Bacterial, Genomic Islands, *Genomics, Interspersed Repetitive Sequences, Neisseria cinerea/genetics, Neisseria gonorrhoeae/genetics, Neisseria lactamica/genetics, Neisseria meningitidis/*genetics/pathogenicity, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis, Prophages/genetics, Synteny, Virulence/genetics | Phylogeny |
Pathogenicity | 17305430 | Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18. | Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ, Parkhill J | PLoS Genet | 10.1371/journal.pgen.0030023 | 2006 | Bacterial Proteins/genetics, Base Composition/genetics, Gene Rearrangement, Genes, Bacterial, *Genetic Variation, Humans, Neisseria meningitidis, Serogroup C/*genetics, Oligonucleotide Array Sequence Analysis, Open Reading Frames/genetics, Repetitive Sequences, Nucleic Acid/genetics, Sequence Homology, Nucleic Acid, Synteny/genetics | Transcriptome |
Phylogeny | 18430216 | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species. | Harrison OB, Maiden MC, Rokbi B | BMC Microbiol | 10.1186/1471-2180-8-66 | 2008 | Bacterial Proteins/chemistry/genetics, Biodiversity, Gonorrhea/microbiology, Humans, Molecular Sequence Data, *Multigene Family, Neisseria/classification/*genetics, Neisseriaceae Infections/microbiology, Phylogeny, Protein Isoforms/chemistry/genetics, Recombination, Genetic, Sequence Analysis, DNA, Transferrin-Binding Protein B/chemistry/*genetics | Pathogenicity |
Phylogeny | 18452423 | Bacteriocins (meningocins) in Norwegian isolates of Neisseria meningitidis: possible role in the course of a meningococcal epidemic. | Allunans J, Kristiansen KI, Assalkhou R, Bjoras M | APMIS | 10.1111/j.1600-0463.2008.00850.x | 2008 | Adult, Bacteriocins/*biosynthesis/classification/genetics, Base Sequence, *Disease Outbreaks, Humans, Meningococcal Infections/*epidemiology/*microbiology/transmission, Molecular Sequence Data, Neisseria meningitidis/classification/genetics/*isolation & purification, Norway/epidemiology, Serotyping | Pathogenicity |
20472803 | Frequency and rate of pilin antigenic variation of Neisseria meningitidis. | Helm RA, Seifert HS | J Bacteriol | 10.1128/JB.00280-10 | 2010 | *Antigenic Variation, Antigens, Bacterial/genetics/*immunology, Fimbriae Proteins/genetics/*immunology, Gene Expression Regulation, Bacterial/physiology, Neisseria gonorrhoeae/genetics/immunology, Neisseria meningitidis/genetics/*immunology | ||
Genetics | 20675487 | Draft genome sequences of two Neisseria meningitidis serogroup C clinical isolates. | Lavezzo E, Toppo S, Barzon L, Cobelli C, Di Camillo B, Finotello F, Franchin E, Peruzzo D, Toffolo GM, Trevisan M, Palu G | J Bacteriol | 10.1128/JB.00789-10 | 2010 | Genome, Bacterial/*genetics, Humans, Molecular Sequence Data, Neisseria meningitidis, Serogroup C/*genetics/isolation & purification | Pathogenicity |
Phylogeny | 24466206 | The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species. | Davies JK, Harrison PF, Lin YH, Bartley S, Khoo CA, Seemann T, Ryan CS, Kahler CM, Hill SA | PLoS One | 10.1371/journal.pone.0086704 | 2014 | *Antigenic Variation, Antigens, Bacterial/*genetics/immunology, Computational Biology, Fimbriae Proteins/genetics/immunology, High-Throughput Nucleotide Sequencing, Neisseria/classification/*genetics/immunology | |
Genetics | 25846515 | Insight into proteomic investigations of Neisseria meningitidis serogroup C strain L91543 from analysis of its genome sequence. | Karlyshev AV, Snyder LA, McFadden J, Griffin R | FEMS Microbiol Lett | 10.1093/femsle/fnv055 | 2015 | Adhesins, Bacterial/genetics, Amino Acid Sequence, Antigens, Bacterial/chemistry/genetics/metabolism, Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, *Genome, Bacterial, Meningococcal Vaccines, Molecular Sequence Data, Neisseria meningitidis, Serogroup C/*genetics, Proteomics, Repressor Proteins/genetics/metabolism, Sequence Alignment | Metabolism |
Metabolism | 28699876 | Characterization of Vsr endonucleases from Neisseria meningitidis. | Bazlekowa M, Adamczyk-Poplawska M, Kwiatek A | Microbiology (Reading) | 10.1099/mic.0.000492 | 2017 | Amino Acid Sequence, Bacterial Proteins/*chemistry/genetics/*metabolism, DNA Methylation, DNA, Bacterial/genetics/metabolism, DNA-Cytosine Methylases/chemistry/genetics/metabolism, Endodeoxyribonucleases/*chemistry/genetics/*metabolism, Kinetics, Mutagenesis, Neisseria meningitidis/chemistry/*enzymology/genetics, Substrate Specificity | Enzymology |
Reference
@id | authors | catalogue | doi/url | title |
---|---|---|---|---|
5939 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 15464) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-15464 | |
20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |
66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |
68377 | Automatically annotated from API NH | |||
79751 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID113595.1 | StrainInfo: A central database for resolving microbial strain identifiers |