Adlercreutzia equolifaciens subsp. equolifaciens (DSM 19450, CCUG 54925, JCM 14793)

Name: Adlercreutzia equolifaciens subsp. equolifaciens (DSM 19450, CCUG 54925, JCM 14793)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 3073

Type strain

Strain Designation FJC-B9

Culture col. no. DSM 19450 CCUG 54925 JCM 14793 KCTC 15235 FJC-B9

NCBI tax ID(s) 446660 2864143

Special Collections DSMZ CCUG JCM KCTC Literature strains

History DSMZ <- Toshinari Maruo; FJC-B9 JCM <-- T. Maruo FJC-B9. KCTC <- CCUG <- Toshinari Maruo, FJC-B9

Links

Adlercreutzia equolifaciens subsp. equolifaciens FJC-B9 is an anaerobe, Gram-positive, ovoid-shaped bacterium that was isolated from human faeces.

Gram-positive ovoid-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 406541

JCM 14793,KCTC 15235,DSM 19450,CCUG 54925

@ref 20215

Last LPSN update 2026-05-29 08:25:37

Domain Bacteria

Phylum Actinomycetota

Class Coriobacteriia

Order Eggerthellales

Family Eggerthellaceae

Genus Adlercreutzia

Species Adlercreutzia equolifaciens subsp. equolifaciens

Full scientific name Adlercreutzia equolifaciens subsp. equolifaciens (Maruo et al. 2008) Nouioui et al. 2018

Morphology

Cell morphology

@ref	Gram stain	Cell length	Cell width	Cell shape	Confidence
32379	positive	2.1 µm	0.65 µm	ovoid-shaped
67771
67771	positive
125439	negative				93.298

Colony morphology

60388

Incubation period2-3 days

Pigmentation

32379

Productionyes

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
8024	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)		Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
8024	WILKINS-CHALGREN ANAEROBE BROTH (DSMZ Medium 339)		Medium recipe at MediaDive	Name: WILKINS-CHALGREN ANAEROBE BROTH (DSMZ Medium 339) Composition: dehydrated Wilkins-Chalgren medium 33.0 g/l L-Cysteine HCl 0.3 g/l Sodium resazurin 0.0005 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
8024	positive	growth	37
60388	positive	growth	37
67770	positive	growth	37
67771	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
8024	anaerobe
32379	anaerobe
60388	anaerobe
67771	anaerobe
125439	obligate anaerobe	97.696

Spore formation

@ref	Spore formation	Confidence
32379
67771
125439		99.811

Observation

@ref	Observation
67770	quinones: DMMK-6
67771	quinones: DMMK-6(70-96%), MMK-6(1-29%)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
32379	29016 ChEBI	arginine	+	carbon source
68380	29016 ChEBI	arginine	+	hydrolysis	from API rID32A
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68380	alpha-galactosidase	-	3.2.1.22	from API rID32A
68380	alpha-glucosidase	-	3.2.1.20	from API rID32A
68380	arginine dihydrolase	+	3.5.3.6	from API rID32A
68380	beta-galactosidase	-	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
8024	-	+	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
8024	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)

Isolation

@ref	Sample type	Host species	Sampling date	Country	Country ISO 3 Code	Continent
8024	human faeces	Homo sapiens		Japan	JPN	Asia
60388	Human feces,25-yr-old healthy woman	Homo sapiens	2006-06-01	Japan	JPN	Asia
67770	Human feces	Homo sapiens
67771	From human feces	Homo sapiens		Japan	JPN	Asia

Taxonmaps

69479

Global distribution of 16S sequence AB649147 (>99% sequence identity) for Adlercreutzia equolifaciens subclade from Microbeatlas

Aquatic Samples	2542
Soil Samples	562
Animal Samples	99975
Plant Samples	215
Total Samples	103294

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8024	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM47888v1 assembly for Adlercreutzia equolifaciens DSM 19450	complete	GCA_000478885	1384484.3	2597489914	1384484	97.14
66792	ASM342823v1 assembly for Adlercreutzia equolifaciens KCTC 15235	contig	GCA_003428235	446660.3		446660	9.8

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Adlercreutzia equolifaciens gene for 16S ribosomal RNA, partial sequence	AB649147	1469		446660
8024	Adlercreutzia equolifaciens gene for 16S ribosomal RNA, partial sequence, strain: FJC-B9	AB306661	1469		446660

GC content

@ref	GC-content (mol%)	Method
8024	64.1
32379	64
67770	64	high performance liquid chromatography (HPLC)
67771	64.0

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM47888v1 assembly for Adlercreutzia equolifaciens DSM 19450
BV-BRC: 1384484.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate anaerobe	97.70	no
125439	gram_stain	BacteriaNetⓘ	negative	93.30	no
125439	motility	BacteriaNetⓘ	yes	68.09	no
125439	spore_formation	BacteriaNetⓘ	no	99.81	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Adlercreutzia equolifaciens DSM 19450 DSM 19450
NCBI: GCA_000478885.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	83.77	yes
125438	anaerobic	anaerobicⓘ	yes	89.91	yes
125438	aerobic	aerobicⓘ	no	95.58	no
125438	spore-forming	spore-formingⓘ	no	85.68	yes
125438	thermophilic	thermophileⓘ	no	89.15	no
125438	flagellated	motile2+ⓘ	no	88.53	yes

Literature

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme.	Bae M, Le C, Mehta RS, Dong X, Pieper LM, Ramirez L, Alexander M, Kiamehr S, Turnbaugh PJ, Huttenhower C, Chan AT, Balskus EP.	Cell Host Microbe	10.1016/j.chom.2024.10.002	2024
Pathogenicity	Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease.	Onate FP, Chamignon C, Burz SD, Lapaque N, Monnoye M, Philippe C, Bredel M, Chene L, Farin W, Paillarse JM, Boursier J, Ratziu V, Mousset PY, Dore J, Gerard P, Blottiere HM.	Int J Mol Sci	10.3390/ijms241512232	2023
Pathogenicity	Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis.	Gupta VK, Janda GS, Pump HK, Lele N, Cruz I, Cohen I, Ruff WE, Hafler DA, Sung J, Longbrake EE.	Neurol Neuroimmunol Neuroinflamm	10.1212/nxi.0000000000200355	2025
	A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein.	Leonard LM, Simpson AMR, Li S, Reddivari L, Cross TL.	Nutrients	10.3390/nu16071079	2024
Phylogeny	Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD.	Larsen JS, Miller M, Oakley AJ, Dixon NE, Lewis PJ.	Microbiologyopen	10.1002/mbo3.1251	2021
	Maximizing the Estrogenic Potential of Soy Isoflavones through the Gut Microbiome: Implication for Cardiometabolic Health in Postmenopausal Women.	Leonard LM, Choi MS, Cross TL.	Nutrients	10.3390/nu14030553	2022
Metabolism	Microbial transformation of dietary xenobiotics shapes gut microbiome composition.	Culp EJ, Nelson NT, Verdegaal AA, Goodman AL.	Cell	10.1016/j.cell.2024.08.038	2024
	Complete Genome Sequence of Coriobacteriaceae Strain 68-1-3, a Novel Mucus-Degrading Isolate from the Swine Intestinal Tract.	Looft T, Bayles DO, Alt DP, Stanton TB.	Genome Announc	10.1128/genomea.01143-15	2015
Pathogenicity	Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice.	Rodriguez-Daza MC, Daoust L, Boutkrabt L, Pilon G, Varin T, Dudonne S, Levy E, Marette A, Roy D, Desjardins Y.	Sci Rep	10.1038/s41598-020-58863-1	2020
Genetics	Novel Microorganisms Contribute to Biosulfidogenesis in the Deep Layer of an Acidic Pit Lake.	Ayala-Munoz D, Burgos WD, Sanchez-Espana J, Falagan C, Couradeau E, Macalady JL.	Front Bioeng Biotechnol	10.3389/fbioe.2022.867321	2022
Pathogenicity	Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior.	Lukic I, Getselter D, Ziv O, Oron O, Reuveni E, Koren O, Elliott E.	Transl Psychiatry	10.1038/s41398-019-0466-x	2019
	The Chemistry of Gut Microbial Metabolism of Polyphenols.	Stevens JF, Maier CS.	Phytochem Rev	10.1007/s11101-016-9459-z	2016
	Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis.	Jensen SN, Cady NM, Shahi SK, Peterson SR, Gupta A, Gibson-Corley KN, Mangalam AK.	Sci Adv	10.1126/sciadv.abd4595	2021
	Design, construction, and in vivo augmentation of a complex gut microbiome.	Cheng AG, Ho PY, Aranda-Diaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA.	Cell	10.1016/j.cell.2022.08.003	2022
Genetics	A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.	Bisanz JE, Soto-Perez P, Noecker C, Aksenov AA, Lam KN, Kenney GE, Bess EN, Haiser HJ, Kyaw TS, Yu FB, Rekdal VM, Ha CWY, Devkota S, Balskus EP, Dorrestein PC, Allen-Vercoe E, Turnbaugh PJ.	Cell Host Microbe	10.1016/j.chom.2020.04.006	2020
	Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India.	Singh H, Kaur M, Jangra M, Mishra S, Nandanwar H, Pinnaka AK.	Sci Rep	10.1038/s41598-019-47879-x	2019
	The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol.	Rafii F.	Metabolites	10.3390/metabo5010056	2015
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Metabolism	Gut microbial carbohydrate metabolism contributes to insulin resistance.	Takeuchi T, Kubota T, Nakanishi Y, Tsugawa H, Suda W, Kwon AT, Yazaki J, Ikeda K, Nemoto S, Mochizuki Y, Kitami T, Yugi K, Mizuno Y, Yamamichi N, Yamazaki T, Takamoto I, Kubota N, Kadowaki T, Arner E, Carninci P, Ohara O, Arita M, Hattori M, Koyasu S, Ohno H.	Nature	10.1038/s41586-023-06466-x	2023
	Microbial Flavonoid Metabolism: A Cardiometabolic Disease Perspective.	Osborn LJ, Claesen J, Brown JM.	Annu Rev Nutr	10.1146/annurev-nutr-120420-030424	2021
	Bidirectional Interactions between Green Tea (GT) Polyphenols and Human Gut Bacteria.	Choi SR, Lee H, Singh D, Singh D, Cho D, Chung JO, Roh JH, Kim WG, Lee CH.	J Microbiol Biotechnol	10.4014/jmb.2306.06014	2023
Metabolism	Heterologous expression of equol biosynthesis genes from Adlercreutzia equolifaciens.	Vazquez L, Florez AB, Rodriguez J, Mayo B	FEMS Microbiol Lett	10.1093/femsle/fnab082	2021
Metabolism	Metabolism of Soy Isoflavones by Intestinal Bacteria: Genome Analysis of an Adlercreutzia Equolifaciens Strain That Does Not Produce Equol.	Vazquez L, Florez AB, Redruello B, Mayo B	Biomolecules	10.3390/biom10060950	2020
Metabolism	Transcriptional Regulation of the Equol Biosynthesis Gene Cluster in Adlercreutzia equolifaciens DSM19450(T).	Florez AB, Vazquez L, Rodriguez J, Redruello B, Mayo B	Nutrients	10.3390/nu11050993	2019
Metabolism	Biotransformation of (-)-epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism.	Takagaki A, Nanjo F	Biol Pharm Bull	10.1248/bpb.b14-00646	2015
Genetics	Complete Genome Sequence of the Equol-Producing Bacterium Adlercreutzia equolifaciens DSM 19450T.	Toh H, Oshima K, Suzuki T, Hattori M, Morita H	Genome Announc	10.1128/genomeA.00742-13	2013
Phylogeny	Azospirillum fermentarium sp. nov., a nitrogen-fixing species isolated from a fermenter.	Lin SY, Liu YC, Hameed A, Hsu YH, Lai WA, Shen FT, Young CC.	Int J Syst Evol Microbiol	10.1099/ijs.0.050872-0	2013
Phylogeny	Adlercreutzia hattorii sp. nov., an equol non-producing bacterium isolated from human faeces.	Sakamoto M, Ikeyama N, Yuki M, Murakami T, Mori H, Iino T, Ohkuma M	Int J Syst Evol Microbiol	10.1099/ijsem.0.005121	2021
Phylogeny	Ellagibacter isourolithinifaciens gen. nov., sp. nov., a new member of the family Eggerthellaceae, isolated from human gut.	Beltran D, Romo-Vaquero M, Espin JC, Tomas-Barberan FA, Selma MV	Int J Syst Evol Microbiol	10.1099/ijsem.0.002735	2018
Phylogeny	Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella.	Maruo T, Sakamoto M, Ito C, Toda T, Benno Y	Int J Syst Evol Microbiol	10.1099/ijs.0.65404-0	2008

References

#8024	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 19450
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#28606	IJSEM 1221 2008 ( DOI 10.1099/ijs.0.65404-0 , PubMed 18450717 )
#32379	Barberan A, Caceres Velazquez H, Jones S, Fierer N.: Hiding in Plain Sight: Mining Bacterial Species Records for Phenotypic Trait Information. mSphere 2: 2017 ( DOI 10.1128/mSphere.00237-17 , PubMed 28776041 ) - originally annotated from #28606
#60388	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 54925
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#67771	Korean Collection for Type Cultures (KCTC) ; Curators of the KCTC;
#68380	Automatically annotated from API rID32A .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Adlercreutzia equolifaciens subsp. equolifaciens (DSM 19450, CCUG 54925, JCM 14793)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Pigmentation

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Observation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API rID32A

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000478885

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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