Bifidobacterium thermophilum (DSM 20210, ATCC 25525, CIP 105420)

Name: Bifidobacterium thermophilum (DSM 20210, ATCC 25525, CIP 105420)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 1721

Type strain

Strain Designation P2-91

Culture col. no. DSM 20210 ATCC 25525 CIP 105420 CCUG 34983 P2-91 10 more

NCBI tax ID(s) 1437596 33905

Special Collections DSMZ CCUG JCM KCTC CIP

History DSMZ <- T. Mitsuoka, P2-91 JCM <-- ATCC 25525 <-- T. Mitsuoka J18-P2-91. CIP <- 1998, DSM <- T. Mitsuoka: strain P2-91

Links

Bifidobacterium thermophilum P2-91 is an anaerobe, Gram-negative, rod-shaped bacterium that was isolated from pig faeces.

Gram-negative rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 217569

LMG 11573,ATCC 25525,CCUG 34983,DSM 20210,NCFB 2253,CIP 105420,JCM 1207,CCRC 14669,NCIMB 702253,NCDO2253,KCTC 3225,AS 1.2235,LMG 21813,BCRC 14669,HAMBI 111,CGMCC 1.2596,CGMCC 1.2235,AS 1.2596

@ref 20215

Last LPSN update 2026-05-29 08:25:19

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Bifidobacteriales

Family Bifidobacteriaceae

Genus Bifidobacterium

Species Bifidobacterium thermophilum

Full scientific name Bifidobacterium thermophilum corrig. Mitsuoka 1969 (Approved Lists 1980)

Synonyms (1)

Bifidobacterium thermophilium

BacDive ID	Other strains from **Bifidobacterium thermophilum** (8)	Type strain
1720	B. thermophilum C3/12, DSM 20209
1722	B. thermophilum RU 326, DSM 20212, ATCC 25866, JCM 1268, ...
158889	B. thermophilum BSM-130-P53-3C, DSM 102827
165461	B. thermophilum JCM 7031
165462	B. thermophilum JCM 7033
165463	B. thermophilum JCM 7034
165464	B. thermophilum JCM 7036
165480	B. thermophilum JCM 7088, ATCC 25867, LMG 18893

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
123507	negative	rod-shaped
125438				93

Colony morphology

123507

Hemolysis ability0

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
8479	BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)	Medium recipe at MediaDive	Name: BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58) Composition: Glucose 10.0 g/l Casein peptone 10.0 g/l Bacto Soytone 5.0 g/l Meat extract 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l MnSO4 x H2O 0.05 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Tween 80 Resazurin Distilled water
39289	MEDIUM 45 - for Columbia agar with sheep blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Sheepblood (100.000 ml)
123507	CIP Medium 45	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
8479	positive	growth	37
39289	positive	growth	37
52433	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
8479	anaerobe
52433	anaerobe

Spore formation

@ref	Spore formation	Confidence
125438		91.443
125439		97.507

Murein

@ref	Murein short key	Type
8479	A21.06	A4ß L-Orn(L-Lys)-D-Glu

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
123507	17057 ChEBI	cellobiose	-	degradation
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
123507	15824 ChEBI	D-fructose	+	degradation
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
123507	17634 ChEBI	D-glucose	+	degradation
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
123507	65327 ChEBI	D-xylose	-	degradation
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
123507	4853 ChEBI	esculin	-	hydrolysis
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
123507	17716 ChEBI	lactose	-	degradation
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
123507	17306 ChEBI	maltose	+	degradation
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	+	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
123507	17632 ChEBI	nitrate	-	reduction
123507	17632 ChEBI	nitrate	+	respiration
123507	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	+	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
123507	17814 ChEBI	salicin	-	degradation
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	+	builds acid from	from API 50CH acid
123507	17992 ChEBI	sucrose	+	degradation
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
123507	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
123507	amylase	+
68382	beta-galactosidase	+	3.2.1.23	from API zym
123507	beta-galactosidase	+	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
123507	caseinase	-	3.4.21.50
123507	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
123507	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
123507	gelatinase	-
123507	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
123507	lipase	-
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
123507	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
123507	tween esterase	-
123507	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

Fatty acid profile

Metadata FA analysis

@ref

52433

Fatty acid	Percentage	ECL
C16:0	23.2	16
C14:0	21.5	14
C18:1 ω9c	17.1	17.769
C16:1 ω9c	7.6	15.774
C18:2 ω6,9c/C18:0 ANTE	5.4	17.724
C19:0 CYCLO ω9c	3.7	18.87
C12:0	3.7	12
Unidentified	2.8	19.323
Unidentified	2.5	18.225
C18:0	2.4	18
C13:0 3OH/C15:1 i I/H	2.1	14.469
C10:0	1.3	10
Unidentified	1.1	18.179
C17:1 ω5c ISO	1	16.461
C18:1 ω6c	1	17.858
C17:1 ω9c	0.9	16.773
C13:1 at 12-13	0.6	12.931
Unidentified	0.5	13.772
Unidentified	0.5	16.238
C16:0 3OH	0.5	17.52
unknown 12.486	0.5	12.486

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
123507	-	-	+	+	-	+	-	-	-	-	-	+	+	+	-	+	-	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
8479	-	-	-	-	-	-	-	-	-	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	+	-	+	+	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Suidae (Pig,Swine)
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)

Isolation

@ref	Sample type
8479	pig faeces
52433	Pig feces
67770	Swine feces
123507	Animal, Pig, feces

Taxonmaps

69479

Global distribution of 16S sequence LC071798 (>99% sequence identity) for Bifidobacterium from Microbeatlas

Aquatic Samples	756
Soil Samples	263
Animal Samples	24173
Plant Samples	166
Total Samples	25358

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8479	1	Risk group (German classification) According to TRBA 466
123507	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	Bifthelum assembly for Bifidobacterium thermophilum JCM 1207	contig	GCA_000741495	33905.21	2600254976	33905	50.18
67770	DSM-20210 assembly for Bifidobacterium thermophilum DSM 20210	contig	GCA_000771265	1437596.3	2671180426	1437596	45.29

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Bifidobacterium thermophilum ATCC25525 16S-23S intergenic spacer	U09528	478	33905
20218	Bifidobacterium thermophilum ATCC 25525 16S ribosomal RNA	U10151	1453	33905
20218	Bifidobacterium thermophilum strain DSM 20210 16S ribosomal RNA gene, partial sequence	GQ487648	138	33905
20218	Bifidobacterium thermophilum gene for 16S rRNA, partial sequence, strain: JCM 1207	AB507158	666	33905
20218	Bifidobacterium thermophilum strain JCM 1207 16S ribosomal RNA gene, partial sequence	GQ227712	322	33905
20218	Bifidobacterium thermophilum strain KCTC 3225 16S ribosomal RNA gene, partial sequence	GU361834	1483	33905
20218	Bifidobacterium thermophilum strain LMG 11573 16S ribosomal RNA gene, partial sequence	JX986965	1451	33905
67770	Bifidobacterium thermophilum gene for 16S ribosomal RNA, partial sequence	AB437364	1513	33905
67770	Bifidobacterium thermophilum gene for 16S ribosomal RNA, partial sequence, strain: JCM 1207	LC071798	1377	33905

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Bifthelum assembly for Bifidobacterium thermophilum JCM 1207
BV-BRC: 33905.21

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	74.33	no
125439	gram_stain	BacteriaNetⓘ	positive	72.67	no
125439	motility	BacteriaNetⓘ	no	75.02	no
125439	spore_formation	BacteriaNetⓘ	no	97.51	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Bifidobacterium thermophilum DSM 20210
PATRIC: 1437596.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	86.77	no
125438	anaerobic	anaerobicⓘ	yes	84.82	yes
125438	spore-forming	spore-formingⓘ	no	91.44	no
125438	aerobic	aerobicⓘ	no	95.80	yes
125438	thermophilic	thermophileⓘ	no	92.95	no
125438	flagellated	motile2+ⓘ	no	93.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	The Tetracycline Resistance Gene, tet(W) in Bifidobacterium animalis subsp. lactis Follows Phylogeny and Differs From tet(W) in Other Species.	Nohr-Meldgaard K, Struve C, Ingmer H, Agerso Y.	Front Microbiol	10.3389/fmicb.2021.658943	2021
	Texture promoting capacity and EPS formation by lactic acid bacteria in three different oat-based non-dairy media	Martensson O, Oste R, Holst O.	Eur Food Res Technol		2002
Genetics	Tracking the Taxonomy of the Genus Bifidobacterium Based on a Phylogenomic Approach.	Lugli GA, Milani C, Duranti S, Mancabelli L, Mangifesta M, Turroni F, Viappiani A, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02249-17	2018
	Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase.	Seo DH, Yoo SH, Choi SJ, Kim YR, Park CS.	Food Sci Biotechnol	10.1007/s10068-019-00686-6	2020
Phylogeny	Identification of species belonging to the Bifidobacterium genus by PCR-RFLP analysis of a hsp60 gene fragment.	Baffoni L, Stenico V, Strahsburger E, Gaggia F, Di Gioia D, Modesto M, Mattarelli P, Biavati B.	BMC Microbiol	10.1186/1471-2180-13-149	2013
Metabolism	Diversity, ecology and intestinal function of bifidobacteria.	Bottacini F, Ventura M, van Sinderen D, O'Connell Motherway M.	Microb Cell Fact	10.1186/1475-2859-13-s1-s4	2014
Enzymology	Species-specific oligonucleotide probes for five Bifidobacterium species detected in human intestinal microflora.	Yamamoto T, Morotomi M, Tanaka R.	Appl Environ Microbiol	10.1128/aem.58.12.4076-4079.1992	1992
Genetics	Draft genome sequence of Bifidobacterium thermophilum CCRC isolated from chicken faeces.	Mani S, Mamphogoro TP.	Microbiol Resour Announc	10.1128/mra.00845-25	2025
	Characterization of a novel Glutaminase-free L-asparaginase from Bifidobacterium thermophilum.	Ge J, Huang X, Zhang Z.	Prep Biochem Biotechnol	10.1080/10826068.2025.2559284	2025
Enzymology	Enhanced production of turanose using a mutant amylosucrase from Bifidobacterium thermophilum immobilized on silica carriers.	Choi BY, Seo DH, Hamaker BR, Yoo SH.	Int J Biol Macromol	10.1016/j.ijbiomac.2024.136981	2024
	Dynamics of microbial communities during inulin fermentation associated with the temporal response in SCFA production	Wei S, Wang C, Zhang Q, Yang H, Deehan EC, Zong X, Wang Y, Jin M.	Carbohydrate polymers.		2023
	Production of branched glucan polymer by a novel thermostable branching enzyme of Bifidobacterium thermophilum via one-pot biosynthesis containing a dual enzyme system	Jin SH, Kwon TE, Kang JU, Yoo SH, Chang PS, Yoo SH.	Carbohydrate polymers.		2023
	Production of branched glucan polymer by a novel thermostable branching enzyme of Bifidobacterium thermophilum via one-pot biosynthesis containing a dual enzyme system.	Jin SH, Kwon TE, Kang JU, Yoo SH, Chang PS, Yoo SH.	Carbohydr Polym	10.1016/j.carbpol.2023.120646	2023
	Gut microbiota-derived short-chain fatty acids promote follicular maturation via gWAT-ovary axis in mammals.	Xu B, Qin W, Chen Y, Yan Z, Tang Y, Zhou S, Huang J, Ma L, Yan X.	Microbiome	10.1186/s40168-025-02174-y	2025
	A GH42 beta-galactosidase from Bifidobacterium thermophilum: Biochemical characterization and synthesis of galactosyl glycerol by reverse hydrolysis.	Duan J, Jia X, Cao K, Gao Z.	Biotechnol Appl Biochem	10.1002/bab.2408	2023
	Study on Fermentation Preparation, Stability, and Angiotensin-Converting Enzyme Inhibitory Activity of Tomato Pomace Peptide.	Mu Y, Maimaitiyiming R, Hong J, Wang Y, Zhao Y, Liu R, Wang L, Chen K, Aihaiti A.	Foods	10.3390/foods14020145	2025
	Dynamics of microbial communities during inulin fermentation associated with the temporal response in SCFA production.	Wei S, Wang C, Zhang Q, Yang H, Deehan EC, Zong X, Wang Y, Jin M.	Carbohydr Polym	10.1016/j.carbpol.2022.120057	2022
	Site-Directed Mutagenic Engineering of a Bifidobacterium Amylosucrase toward Greater Efficiency of Turanose Synthesis.	Jun SJ, Lee JA, Kim YW, Yoo SH.	J Agric Food Chem	10.1021/acs.jafc.1c06126	2022
Metabolism	Interactions between probiotic and oral pathogenic strains.	Gonczi NN, Strang O, Bagi Z, Rakhely G, Kovacs KL.	Biol Futur	10.1007/s42977-021-00091-3	2021
	Synergistic Engineering of the Twin-Arginine Translocation (Tat) Pathway and Membrane Capacity Enhances Extracellular Production of Amylosucrase in Bacillus licheniformis.	Wang C, Niu D, Zhou Y, Liu H, Mchunu NP, Zhang M, Singh S, Wang Z.	Microorganisms	10.3390/microorganisms13061179	2025
	Genome analysis of the temperate bacteriophage PMBT6 residing in the genome of Bifidobacterium thermophilum MBT94004.	Sprotte S, Bockelmann W, Brinks E, Schleifenbaum P, Cho GS, Fiedler G, Heller KJ, Franz CMAP, Neve H.	Arch Virol	10.1007/s00705-019-04448-x	2020
Pathogenicity	Evaluation of the in vitro effects of the increasing inclusion levels of yeast beta-glucan, a casein hydrolysate and its 5 kDa retentate on selected bacterial populations and strains commonly found in the gastrointestinal tract of pigs.	Venardou B, O'Doherty JV, McDonnell MJ, Mukhopadhya A, Kiely C, Ryan MT, Sweeney T.	Food Funct	10.1039/d0fo02269a	2021
	Sucrose-based biosynthetic process for chain-length-defined alpha-glucan and functional sweetener by Bifidobacterium amylosucrase.	Choi SW, Lee JA, Yoo SH.	Carbohydr Polym	10.1016/j.carbpol.2018.10.064	2019
	Probiotic supplementation in sustainable sheep production: impacts on health, performance, and methane mitigation.	Saleem ASA, Abdelnour S, Bassiony SM, Abdel-Monem UM, Elaref MY, Al-Marakby KM.	Trop Anim Health Prod	10.1007/s11250-025-04439-y	2025
Metabolism	Enhancing oxidative stress resistance in Bifidobacterium thermophilum using a novel overexpression vector and transformation protocol.	Stevens MJA, Venturini A, Lacroix C, Meile L.	Plasmid	10.1016/j.plasmid.2017.06.002	2017
	Comparison of single- and multi-strain probiotics effects on broiler breeder performance, egg production, egg quality and hatchability.	Aalaei M, Khatibjoo A, Zaghari M, Taherpour K, Akbari Gharaei M, Soltani M.	Br Poult Sci	10.1080/00071668.2018.1496400	2018
	Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial.	Younan S, Sakita GZ, Coluna JGY, Rufino MN, Keller R, Bremer-Neto H.	J Sci Food Agric	10.1002/jsfa.9159	2019
	The relationship between prebiotic intake and allergic rhinitis.	Chang C, Wang Q, Wang Q, Li X, Tan H, Huang G.	Laryngoscope Investig Otolaryngol	10.1002/lio2.1158	2023
	Multi-omic profiling reveals distinct gut microbial and metabolic landscapes in golden snub-nosed monkeys under contrasting conservation strategies.	Zhang D, Hu Q, Zhou Y, Yu H, Cong W, Cheng M, Wang J, Liu X, Zou K, Long S, Zhao C, Jiang J, Zhang Y.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00836-1	2025
Enzymology	Developing a procedure to extract chenodeoxycholic acid and synthesize ursodeoxycholic acid from pig by-products.	Kim OY, Lee SY, Lee DY, Hur SJ.	Heliyon	10.1016/j.heliyon.2023.e18313	2023
Genetics	Commercial farmed swine harbour a variety of pathogenic bacteria and antimicrobial resistance genes.	Eiamsam-Ang T, Tadee P, Buddhasiri S, Chuammitri P, Kittiwan N, Pascoe B, Patchanee P.	J Med Microbiol	10.1099/jmm.0.001787	2024
	Secretory expression of amylosucrase in Bacillus licheniformis through twin-arginine translocation pathway.	Wang C, Niu D, Mchunu NP, Zhang M, Singh S, Wang Z.	J Ind Microbiol Biotechnol	10.1093/jimb/kuae004	2024
Metabolism	Differences in Bacterial Small RNAs in Stool Samples from Hypercholesterolemic and Normocholesterolemic Subjects.	Morales C, Arias-Carrasco R, Maracaja-Coutinho V, Seron P, Lanas F, Salazar LA, Saavedra N.	Int J Mol Sci	10.3390/ijms24087213	2023
	In Vitro Evaluation of Brown Seaweed Laminaria spp. as a Source of Antibacterial and Prebiotic Extracts That Could Modulate the Gastrointestinal Microbiota of Weaned Pigs.	Venardou B, O'Doherty JV, Garcia-Vaquero M, Kiely C, Rajauria G, McDonnell MJ, Ryan MT, Sweeney T.	Animals (Basel)	10.3390/ani13050823	2023
	Hydrolyzation of snail (Achatina fulica) meat with rice water as novel probiotic supplements for animal feed.	Suryadi U, Hertamawati RT, Imam AS.	Vet World	10.14202/vetworld.2022.937-942	2022
	Effects of probiotic (Lactobacillus plantarum and Bacillus subtilis) supplementation on mortality, growth performance, and carcass characteristics of native Vietnamese broilers challenged with Salmonella Typhimurium.	Nam TVB, Anh LH, Loc HT, Trang CTH, Thiet N, Lan LTT, Diep TH, Xuan NH, Ngu NT.	Vet World	10.14202/vetworld.2022.2302-2308	2022
	The Recent Trend in the Use of Multistrain Probiotics in Livestock Production: An Overview.	Lambo MT, Chang X, Liu D.	Animals (Basel)	10.3390/ani11102805	2021
	The impact of wild-boar-derived microbiota transplantation on piglet microbiota, metabolite profile, and gut proinflammatory cytokine production differs from sow-derived microbiota.	Rahman R, Fouhse JM, Ju T, Fan Y, Bhardwaj T, Brook RK, Nosach R, Harding J, Willing BP.	Appl Environ Microbiol	10.1128/aem.02265-24	2025
	Probiotics in miRNA-Mediated Regulation of Intestinal Immune Homeostasis in Pigs: A Physiological Narrative.	Barcenas-Preciado V, Mata-Haro V.	Microorganisms	10.3390/microorganisms12081606	2024
	Biosynthesis of glyceride glycoside (nonionic surfactant) by amylosucrase, a powerful glycosyltransferase.	Kim YJ, Siziya IN, Hong S, Lee GY, Seo MJ, Kim YR, Yoo SH, Park CS, Seo DH.	Food Sci Biotechnol	10.1007/s10068-020-00861-0	2021
	An In Vitro Colonic Fermentation Study of the Effects of Human Milk Oligosaccharides on Gut Microbiota and Short-Chain Fatty Acid Production in Infants Aged 0-6 Months.	Li M, Lu H, Xue Y, Ning Y, Yuan Q, Li H, He Y, Jia X, Wang S.	Foods	10.3390/foods13060921	2024
	Impact of Global Warming on the Severity of Viral Diseases: A Potentially Alarming Threat to Sustainable Aquaculture Worldwide.	Combe M, Reverter M, Caruso D, Pepey E, Gozlan RE.	Microorganisms	10.3390/microorganisms11041049	2023
Metabolism	The Impact of Multispecies Probiotics on Calcium and Magnesium Status in Healthy Male Rats.	Suliburska J, Harahap IA, Skrypnik K, Bogdanski P.	Nutrients	10.3390/nu13103513	2021
	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study.	Yang KT, Juang SE, Hung YM, Wei JC, Yip HT, Chang R.	Sci Rep	10.1038/s41598-021-81224-5	2021
	Effects of intrinsic and extrinsic growth factors on virulence gene expression of foodborne pathogens in vitro and in food model systems; a review.	Hosseini H, Mahmoudi R, Pakbin B, Manafi L, Hosseini S, Pilevar Z, Bruck WM.	Food Sci Nutr	10.1002/fsn3.4281	2024
	Characterization of the Effects of a Novel Probiotic on Salmonella Colonization of a Piglet-Derived Intestinal Microbiota Using Improved Bioreactor.	Grandmont A, Rhouma M, Letourneau-Montminy MP, Theriault W, Mainville I, Arcand Y, Leduc R, Demers B, Thibodeau A.	Animals (Basel)	10.3390/ani14050787	2024
	Metagenomic and Transcriptomic Analyses Reveal the Differences and Associations Between the Gut Microbiome and Muscular Genes in Angus and Chinese Simmental Cattle.	Zheng Y, Chen J, Wang X, Han L, Yang Y, Wang Q, Yu Q.	Front Microbiol	10.3389/fmicb.2022.815915	2022
	Cross-feeding interactions between human gut commensals belonging to the Bacteroides and Bifidobacterium genera when grown on dietary glycans.	Fernandez-Julia P, Commane DM, van Sinderen D, Munoz-Munoz J.	Microbiome Res Rep	10.20517/mrr.2021.05	2022
	Effects of Hogweed (Heracleum persicum) Powder, Flavophospholipol, and Probiotics as Feed Supplements on the Performance, Carcass and Blood Characteristics, Intestinal Microflora, and Immune Response in Broilers.	Javandel F, Nosrati M, van den Hoven R, Seidavi A, Laudadio V, Tufarelli V.	J Poult Sci	10.2141/jpsa.0180081	2019
Genetics	Host-Diet Effect on the Metabolism of Bifidobacterium.	Satti M, Modesto M, Endo A, Kawashima T, Mattarelli P, Arita M.	Genes (Basel)	10.3390/genes12040609	2021
	Effect of Lactobacillus Species Probiotics on Growth Performance of Dual-Purpose Chicken.	Fesseha H, Demlie T, Mathewos M, Eshetu E.	Vet Med (Auckl)	10.2147/vmrr.s300881	2021
	Biotransformation of hydroquinone into alpha-arbutin by transglucosylation activity of a metagenomic amylosucrase.	Agarwal N, Rai AK, Singh SP.	3 Biotech	10.1007/s13205-021-02909-2	2021
	Effect of Dietary Ginger (Zingiber officinale Roscoe) and Multi-Strain Probiotic on Growth and Carcass Traits, Blood Biochemistry, Immune Responses and Intestinal Microflora in Broiler Chickens.	Qorbanpour M, Fahim T, Javandel F, Nosrati M, Paz E, Seidavi A, Ragni M, Laudadio V, Tufarelli V.	Animals (Basel)	10.3390/ani8070117	2018
	Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.	Aleksandrova EV, Ma CX, Klepacki D, Alizadeh F, Vazquez-Laslop N, Liang JH, Polikanov YS, Mankin AS.	Nat Chem Biol	10.1038/s41589-024-01685-3	2024
	Phylogenetic diversity of core rumen microbiota as described by cryo-ET.	Wimmer BH, Morais S, Zalk R, Mizrahi I, Medalia O.	Microlife	10.1093/femsml/uqad010	2023
	Resistance determinant erm(X) is borne by transposon Tn5432 in Bifidobacterium thermophilum and Bifidobacterium animalis subsp. lactis.	van Hoek AH, Mayrhofer S, Domig KJ, Aarts HJ.	Int J Antimicrob Agents	10.1016/j.ijantimicag.2008.01.025	2008
	Effects of Dietary Chicory (Chicorium intybus L.) and Probiotic Blend as Natural Feed Additives on Performance Traits, Blood Biochemistry, and Gut Microbiota of Broiler Chickens.	Khoobani M, Hasheminezhad SH, Javandel F, Nosrati M, Seidavi A, Kadim IT, Laudadio V, Tufarelli V.	Antibiotics (Basel)	10.3390/antibiotics9010005	2019
	Alteration of fatty acid profile of milk in Holstein cows fed Bacillus coagulans as probiotic: a field study.	Izadi B, Mohebbi-Fani M, Hosseinzadeh S, Shekarforoush SS, Nazifi S, Rasooli A.	Iran J Vet Res	10.22099/ijvr.2021.38159.5558	2021
Phylogeny	The gut microbiota in the common kestrel (Falco tinnunculus): a report from the Beijing Raptor Rescue Center.	Guan Y, Wang H, Gong Y, Ge J, Bao L.	PeerJ	10.7717/peerj.9970	2020
	Effect of Immune Stress on Growth Performance and Immune Functions of Livestock: Mechanisms and Prevention.	Niu X, Ding Y, Chen S, Gooneratne R, Ju X.	Animals (Basel)	10.3390/ani12070909	2022
Genetics	Early microbial intervention reshapes phenotypes of newborn Bos taurus through metabolic regulations.	Shen Y, Li Y, Wu T, Dong Q, Deng Q, Liu L, Guo Y, Cao Y, Li Q, Shi J, Zou H, Jiao Y, Ding L, Li J, Gao Y, Hu S, Wang Y, Chen L.	Gigascience	10.1093/gigascience/giad118	2024
Pathogenicity	Antibiotic susceptibility testing of Bifidobacterium thermophilum and Bifidobacterium pseudolongum strains: broth microdilution vs. agar disc diffusion assay.	Domig KJ, Mayrhofer S, Zitz U, Mair C, Petersson A, Amtmann E, Mayer HK, Kneifel W.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2007.07.064	2007
Phylogeny	In vitro antagonistic activities of animal intestinal strains against swine-associated pathogens.	Klose V, Bayer K, Bruckbeck R, Schatzmayr G, Loibner AP.	Vet Microbiol	10.1016/j.vetmic.2010.02.025	2010
	The Effect of Enterococcus faecium AL41 on the Acute Phase Proteins and Selected Mucosal Immune Molecules in Broiler Chickens.	Karaffova V, Tothova C, Szaboova R, Revajova V, Laukova A, Sevcikova Z, Herich R, Zitnan R, Levkut M, Levkut M, Faixova Z, Nagy O.	Life (Basel)	10.3390/life12040598	2022
	Modulation of the porcine intestinal microbiota in the course of Ascaris suum infection.	Springer A, Wagner L, Koehler S, Klinger S, Breves G, Bruggemann DA, Strube C.	Parasit Vectors	10.1186/s13071-022-05535-w	2022
Pathogenicity	Identification and antimicrobial susceptibility of porcine bacteria that inhibit the growth of Brachyspira hyodysenteriae in vitro.	Klose V, Bruckbeck R, Henikl S, Schatzmayr G, Loibner AP.	J Appl Microbiol	10.1111/j.1365-2672.2009.04521.x	2010
Genetics	Direct Conversion of Food Waste Extract into Caproate: Metagenomics Assessment of Chain Elongation Process.	Crognale S, Braguglia CM, Gallipoli A, Gianico A, Rossetti S, Montecchio D.	Microorganisms	10.3390/microorganisms9020327	2021
Pathogenicity	Antibiotic susceptibility of Bifidobacterium thermophilum and Bifidobacterium pseudolongum isolates from animal sources.	Mayrhofer S, Domig KJ, Amtmann E, Van Hoek AH, Petersson A, Mair C, Mayer HK, Kneifel W.	J Food Prot	10.4315/0362-028x-70.1.119	2007
	Bifidobacterium thermophilum RBL67 impacts on growth and virulence gene expression of Salmonella enterica subsp. enterica serovar Typhimurium.	Tanner SA, Chassard C, Rigozzi E, Lacroix C, Stevens MJ.	BMC Microbiol	10.1186/s12866-016-0659-x	2016
Metabolism	Hydrogen production by anaerobic microbial communities exposed to repeated heat treatments.	Duangmanee T, Padmasiri SI, Simmons JJ, Raskin L, Sung S.	Water Environ Res	10.2175/106143007x175762	2007
Genetics	Characterization of Bifidobacterium asteroides Isolates.	Pino A, Benkaddour B, Inturri R, Amico P, Vaccaro SC, Russo N, Vaccalluzzo A, Agolino G, Caggia C, Miloud H, Randazzo CL.	Microorganisms	10.3390/microorganisms10030655	2022
	The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets.	Yang H, Fan X, Mao X, Yu B, He J, Yan H, Wang J.	J Anim Sci Biotechnol	10.1186/s40104-024-01018-3	2024
Genetics	Development of Real-Time PCR Assay to Specifically Detect 22 Bifidobacterium Species and Subspecies Using Comparative Genomics.	Kim HB, Kim E, Yang SM, Lee S, Kim MJ, Kim HY.	Front Microbiol	10.3389/fmicb.2020.02087	2020
	Swine enteric colibacillosis: Current treatment avenues and future directions.	Castro J, Barros MM, Araujo D, Campos AM, Oliveira R, Silva S, Almeida C.	Front Vet Sci	10.3389/fvets.2022.981207	2022
	No Guts About It: Captivity, But Not Neophobia Phenotype, Influences the Cloacal Microbiome of House Sparrows (Passer domesticus).	Kelly TR, Vinson AE, King GM, Lattin CR.	Integr Org Biol	10.1093/iob/obac010	2022
Pathogenicity	Class I/Class IIa bacteriocin cross-resistance phenomenon in Listeria monocytogenes.	Naghmouchi K, Kheadr E, Lacroix C, Fliss I.	Food Microbiol	10.1016/j.fm.2007.03.012	2007
	Xylooligosaccharides Increase Bifidobacteria and Lachnospiraceae in Mice on a High-Fat Diet, with a Concomitant Increase in Short-Chain Fatty Acids, Especially Butyric Acid.	Berger K, Burleigh S, Lindahl M, Bhattacharya A, Patil P, Stalbrand H, Nordberg Karlsson E, Hallenius F, Nyman M, Adlercreutz P.	J Agric Food Chem	10.1021/acs.jafc.0c06279	2021
	Positive Influence of a Probiotic Mixture on the Intestinal Morphology and Microbiota of Farmed Guinea Fowls (Numida meleagris).	Galosi L, Desantis S, Roncarati A, Robino P, Bellato A, Nebbia P, Ferrocino I, Santamaria N, Biagini L, Filoni L, Attili AR, Rossi G.	Front Vet Sci	10.3389/fvets.2021.743899	2021
	Evaluation of the Antibacterial and Prebiotic Potential of Ascophyllum nodosum and Its Extracts Using Selected Bacterial Members of the Pig Gastrointestinal Microbiota.	Venardou B, O'Doherty JV, Garcia-Vaquero M, Kiely C, Rajauria G, McDonnell MJ, Ryan MT, Sweeney T.	Mar Drugs	10.3390/md20010041	2021
	Colonization of Supplemented Bifidobacterium breve M-16V in Low Birth Weight Infants and Its Effects on Their Gut Microbiota Weeks Post-administration.	Horigome A, Hisata K, Odamaki T, Iwabuchi N, Xiao JZ, Shimizu T.	Front Microbiol	10.3389/fmicb.2021.610080	2021
	Donated Human Milk as a Determinant Factor for the Gut Bifidobacterial Ecology in Premature Babies.	Arboleya S, Saturio S, Suarez M, Fernandez N, Mancabelli L, de Los Reyes-Gavilan CG, Ventura M, Solis G, Gueimonde M.	Microorganisms	10.3390/microorganisms8050760	2020
	Dietary inclusion of multispecies probiotics to reduce the severity of post-weaning diarrhea caused by Escherichia coli F18⁺ in pigs.	Sun Y, Duarte ME, Kim SW.	Anim Nutr	10.1016/j.aninu.2020.08.012	2021
	Enhancement of chicken resistance against Escherichia coli infection by oral administration of Bifidobacterium thermophilum preparations.	Kobayashi C, Yokoyama H, Nguyen SV, Hashi T, Kuroki M, Kodama Y.	Avian Dis	10.1637/0005-2086(2002)046[0542:eocrae]2.0.co;2	2002
Pathogenicity	Effect of Al(III) on surface properties of Bifidobacterium thermophilum as a function of temperature.	Kot E, Bezkorovainy A.	Biol Trace Elem Res	10.1385/bter:86:2:159	2002
Enzymology	Bifidobacterium species isolated from animal feces and from beef and pork meat.	Gavini F, Delcenserie V, Kopeinig K, Pollinger S, Beerens H, Bonaparte C, Upmann M.	J Food Prot	10.4315/0362-028x-69.4.871	2006
Pathogenicity	Eliminating the carriage of Salmonella enterica serovar Enteritidis in domestic fowls by feeding activated charcoal from bark containing wood vinegar liquid (Nekka-Rich).	Watarai S, Tana.	Poult Sci	10.1093/ps/84.4.515	2005
	Chemotaxis Assay for Marsupenaeus japonicas Hemocytes and Application for the Development of an Oral Immunostimulant Against White Spot Syndrome Virus.	Imai T, Takahashi Y.	Front Cell Dev Biol	10.3389/fcell.2020.00046	2020
Metabolism	The effect of nisin on the physiology of Bifidobacterium thermophilum.	Kot E, Murad Y, Bezkorovainy A.	J Food Prot	10.4315/0362-028x-64.8.1206	2001
	The binding of H2O2 -generated Fe(III) to Bifidobacterium thermophilum depends on the method of its production	Kot E, Bezkorovainy A.	J Food Sci	10.1111/j.1365-2621.2000.tb09411.x	2000
	Effect of Dietary Supplementation of Lactobacillus Casei YYL3 and L. Plantarum YYL5 on Growth, Immune Response and Intestinal Microbiota in Channel Catfish.	Zhang H, Wang H, Hu K, Jiao L, Zhao M, Yang X, Xia L.	Animals (Basel)	10.3390/ani9121005	2019
Metabolism	Plasma from patients with anti-glomerular basement membrane disease could recognize microbial peptides.	Li JN, Jia X, Wang Y, Xie C, Jiang T, Cui Z, Zhao MH.	PLoS One	10.1371/journal.pone.0174553	2017
Metabolism	Binding of ferric iron to the cell walls and membranes of Bifidobacterium thermophilum: effect of free radicals.	Kot E, Bezkorovainy A.	J Agric Food Chem	10.1021/jf990474l	1999
	Effect of hydrogen peroxide on the physiology of Bifidobacterium thermophilum.	Kot E, Bezkorovainy A.	J Agric Food Chem	10.1021/jf971041q	1998
	The Efficiency of Probiotics Administrated via Different Routes and Doses in Enhancing Production Performance, Meat Quality, Gut Morphology, and Microbial Profile of Broiler Chickens.	Soumeh EA, Cedeno ADRC, Niknafs S, Bromfield J, Hoffman LC.	Animals (Basel)	10.3390/ani11123607	2021
	Enhancement of disease resistance of kuruma shrimp, Penaeus japonicus, after oral administration of peptidoglycan derived from Bifidobacterium thermophilum	Itami T, Asano M, Tokushige K, Kubono K, Nakagawa A, Takeno N, Nishimura H, Maeda M, Kondo M, Takahashi Y.	Aquaculture	10.1016/s0044-8486(98)00193-8	1998
Metabolism	Adsorption effect of activated charcoal on enterohemorrhagic Escherichia coli.	Naka K, Watarai S, Tana, Inoue K, Kodama Y, Oguma K, Yasuda T, Kodama H.	J Vet Med Sci	10.1292/jvms.63.281	2001
Pathogenicity	Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella.	Venardou B, O'Doherty JV, Maher S, Ryan MT, Gath V, Ravindran R, Kiely C, Rajauria G, Garcia-Vaquero M, Sweeney T.	J Anim Sci Biotechnol	10.1186/s40104-022-00685-4	2022
	Analysis of the Productivity, Immunity, and Health Performance of Nile Tilapia (Oreochromis niloticus) Broodstock-fed Dietary Fermented Extracts Sourced from Saccharomyces cerevisiae (Hilyses): A Field Trial.	Abu-Elala NM, Ali TE, Ragaa NM, Ali SE, Abd-Elsalam RM, Younis NA, Abdel-Moneam DA, Hamdien AH, Bonato M, Dawood MAO.	Animals (Basel)	10.3390/ani11030815	2021
	Mosaic tetracycline resistance genes and their flanking regions in Bifidobacterium thermophilum and Lactobacillus johnsonii.	van Hoek AH, Mayrhofer S, Domig KJ, Florez AB, Ammor MS, Mayo B, Aarts HJ.	Antimicrob Agents Chemother	10.1128/aac.00714-07	2008
	PCR and real-time PCR primers developed for detection and identification of Bifidobacterium thermophilum in faeces.	Mathys S, Lacroix C, Mini R, Meile L.	BMC Microbiol	10.1186/1471-2180-8-179	2008
Metabolism	Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.	Svetlov MS, Syroegin EA, Aleksandrova EV, Atkinson GC, Gregory ST, Mankin AS, Polikanov YS.	Nat Chem Biol	10.1038/s41589-020-00715-0	2021
Metabolism	Phagocytosis of splenetic neutrophils of mice enhanced by orally administered peptidoglycan from Bifidobacterium thermophilum.	Sasaki T, Samegai Y, Namioka S.	J Vet Med Sci	10.1292/jvms.58.85	1996
Metabolism	Angicin, a novel bacteriocin of Streptococcus anginosus.	Vogel V, Bauer R, Mauerer S, Schiffelholz N, Haupt C, Seibold GM, Fandrich M, Walther P, Spellerberg B.	Sci Rep	10.1038/s41598-021-03797-5	2021
Pathogenicity	Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.	Kadlec K, Brenner Michael G, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Watts JL, Schwarz S.	Antimicrob Agents Chemother	10.1128/aac.00092-11	2011
Phylogeny	Classification of a moderately oxygen-tolerant isolate from baby faeces as Bifidobacterium thermophilum.	von Ah U, Mozzetti V, Lacroix C, Kheadr EE, Fliss I, Meile L.	BMC Microbiol	10.1186/1471-2180-7-79	2007
Metabolism	A Gene Homologous to rRNA Methylase Genes Confers Erythromycin and Clindamycin Resistance in Bifidobacterium breve.	Martinez N, Luque R, Milani C, Ventura M, Banuelos O, Margolles A.	Appl Environ Microbiol	10.1128/aem.02888-17	2018
	Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.	Zhu DK, Luo HY, Liu MF, Zhao XX, Jia RY, Chen S, Sun KF, Yang Q, Wu Y, Chen XY, Cheng AC, Wang MS.	Front Microbiol	10.3389/fmicb.2018.00585	2018
Pathogenicity	Enhancement of cytotoxic activity of lymphocytes in mice by oral administration of peptidoglycan (PG) derived from Bifidobacterium thermophilum.	Sasaki T, Fukami S, Namioka S.	J Vet Med Sci	10.1292/jvms.56.1129	1994
	Effects of a blend of Saccharomyces cerevisiae-based direct-fed microbial and fermentation products in the diet of newly weaned beef steers: growth performance, whole-blood immune gene expression, serum biochemistry, and plasma metabolome1.	Adeyemi JA, Harmon DL, Compart DMP, Ogunade IM.	J Anim Sci	10.1093/jas/skz308	2019
	Enhanced resistance of mice to Escherichia coli infection induced by administration of peptidoglycan derived from Bifidobacterium thermophilum.	Sasaki T, Fukami S, Namioka S.	J Vet Med Sci	10.1292/jvms.56.433	1994
	Productive performance, fertility and hatchability, blood indices and gut microbial load in laying quails as affected by two types of probiotic bacteria.	Nour MA, El-Hindawy MM, Abou-Kassem DE, Ashour EA, Abd El-Hack ME, Mahgoub S, Aboelenin SM, Soliman MM, El-Tarabily KA, Abdel-Moneim AE.	Saudi J Biol Sci	10.1016/j.sjbs.2021.07.030	2021
Metabolism	Effects of Mg2+ and Ca2+ on Fe2+ uptake by Bifidobacterium thermophilum.	Kot E, Bezkorovainy A.	Int J Biochem	10.1016/0020-711x(93)90117-w	1993
	Digoxigenin-labeled deoxyribonucleic acid probes for the enumeration of bifidobacteria in fecal samples.	Kaneko T, Kurihara H.	J Dairy Sci	10.3168/jds.s0022-0302(97)76054-5	1997
	Feed supplementation with biochar may reduce poultry pathogens, including Campylobacter hepaticus, the causative agent of Spotty Liver Disease.	Willson NL, Van TTH, Bhattarai SP, Courtice JM, McIntyre JR, Prasai TP, Moore RJ, Walsh K, Stanley D.	PLoS One	10.1371/journal.pone.0214471	2019
	Effect of Selenium Sources on Laying Performance, Egg Quality Characteristics, Intestinal Morphology, Microbial Population and Digesta Volatile Fatty Acids in Laying Hens.	Muhammad AI, Mohamed DA, Chwen LT, Akit H, Samsudin AA.	Animals (Basel)	10.3390/ani11061681	2021
	Longitudinal Analysis of the Intestinal Microbiota in the Obese Mangalica Pig Reveals Alterations in Bacteria and Bacteriophage Populations Associated With Changes in Body Composition and Diet.	Hallowell HA, Higgins KV, Roberts M, Johnson RM, Bayne J, Maxwell HS, Brandebourg T, Hiltbold Schwartz E.	Front Cell Infect Microbiol	10.3389/fcimb.2021.698657	2021
	Distribution of accumulated iron in Bifidobacterium thermophilum.	Kot E, Bezkorovainy A.	J Agric Food Chem	10.1021/jf00026a005	1993
Metabolism	Iron uptake by Bifidobacterium thermophilum protoplasts.	Kot E, Miller-Catchpole R, Bezkorovainy A.	Biol Trace Elem Res	10.1007/bf02783977	1993
	Sex, Age, and Bacteria: How the Intestinal Microbiota Is Modulated in a Protandrous Hermaphrodite Fish.	Piazzon MC, Naya-Catala F, Simo-Mirabet P, Picard-Sanchez A, Roig FJ, Calduch-Giner JA, Sitja-Bobadilla A, Perez-Sanchez J.	Front Microbiol	10.3389/fmicb.2019.02512	2019
Genetics	Metagenomic Analysis of Chicken Gut Microbiota for Improving Metabolism and Health of Chickens - A Review.	Choi KY, Lee TK, Sul WJ.	Asian-Australas J Anim Sci	10.5713/ajas.15.0026	2015
	Bovine Immunology: Implications for Dairy Cattle.	Vlasova AN, Saif LJ.	Front Immunol	10.3389/fimmu.2021.643206	2021
	Electron microscopic, biochemical and physiological studies of Bifidobacterium pseudolongum SS-24 and Bifidobacterium thermophilum SS-19.	Kudo H, Kimura N, Suzuki M, Cheng KJ, Costerton JW, Mitsuoka T.	Zentralbl Bakteriol	10.1016/s0934-8840(89)80024-6	1989
Metabolism	Differences in the digestive enzyme activity, intestinal mucosa and microbial community in loach cultivated in two separate environments.	Yang S, Du J, Duan YL, Xiao Q, Li NQ, Lin Q, Zhao LL, Du ZJ, Zhou J, Du J.	BMC Microbiol	10.1186/s12866-018-1237-1	2018
Metabolism	Increase of mannose residues, as Salmonella typhimurium-adhering factor, on the cecal mucosa of germ-free chickens infected with Eimeria tenella.	Baba E, Tsukamoto Y, Fukata T, Sasai K, Arakawa A.	Am J Vet Res	10.2460/ajvr.1993.54.09.1471	1993
	Adhesion of bacteria to the cecal mucosal surface of conventional and germ-free chickens infected with Eimeria tenella.	Baba E, Wakeshima H, Fukui K, Fukata T, Arakawa A.	Am J Vet Res	10.2460/ajvr.1992.53.02.194	1992
	Detection of the pediocin gene pedA in strains from human faeces by real-time PCR and characterization of Pediococcus acidilactici UVA1.	Mathys S, von Ah U, Lacroix C, Staub E, Mini R, Cereghetti T, Meile L.	BMC Biotechnol	10.1186/1472-6750-7-55	2007
	Population of Salmonella serovar typhimurium in the cecum of gnotobiotic chickens with Escherichia coli and intestinal bacteria.	Fukata T, Tsutsui H, Baba E, Arakawa A.	J Vet Med Sci	10.1292/jvms.53.229	1991
Pathogenicity	The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity.	Kang JK, Hwang JS, Nam HJ, Ahn KJ, Seok H, Kim SK, Yun EY, Pothoulakis C, Lamont JT, Kim H.	Antimicrob Agents Chemother	10.1128/aac.00177-11	2011
	Population of Salmonella typhimurium in the cecum of gnotobiotic chickens.	Fukata T, Baba E, Arakawa A.	Poult Sci	10.3382/ps.0680311	1989
Metabolism	Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling.	Yan S, Khambu B, Chen X, Dong Z, Guo G, Yin XM.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2020.10.011	2021
	Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium.	Briner AE, Lugli GA, Milani C, Duranti S, Turroni F, Gueimonde M, Margolles A, van Sinderen D, Ventura M, Barrangou R.	PLoS One	10.1371/journal.pone.0133661	2015
Phylogeny	Holobionts and ecological speciation: the intestinal microbiota of lake whitefish species pairs.	Sevellec M, Derome N, Bernatchez L.	Microbiome	10.1186/s40168-018-0427-2	2018
	The Bacillus subtilis and Lactic Acid Bacteria Probiotics Influences Intestinal Mucin Gene Expression, Histomorphology and Growth Performance in Broilers.	Aliakbarpour HR, Chamani M, Rahimi G, Sadeghi AA, Qujeq D.	Asian-Australas J Anim Sci	10.5713/ajas.2012.12110	2012
	The influence of various bacteria on the cecal mucosa of monoflora chickens infected with Eimeria tenella. A scanning electron microscopic study.	Kageyama A, Fukata T, Baba E, Arakawa A.	Zentralbl Bakteriol Mikrobiol Hyg A	10.1016/s0176-6724(87)80253-5	1987
	Effect of infection with Eimeria tenella upon the cecal bacterial population in monoflora chickens.	Fukata T, Kageyama A, Baba E, Arakawa A.	Poult Sci	10.3382/ps.0660841	1987
Metabolism	Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation.	Sakanaka M, Gotoh A, Yoshida K, Odamaki T, Koguchi H, Xiao JZ, Kitaoka M, Katayama T.	Nutrients	10.3390/nu12010071	2019
	Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors.	Kawahara T, Makizaki Y, Oikawa Y, Tanaka Y, Maeda A, Shimakawa M, Komoto S, Moriguchi K, Ohno H, Taniguchi K.	PLoS One	10.1371/journal.pone.0173979	2017
Enzymology	Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR.	Martin R, Jimenez E, Heilig H, Fernandez L, Marin ML, Zoetendal EG, Rodriguez JM.	Appl Environ Microbiol	10.1128/aem.02063-08	2009
Phylogeny	Immunological relationships among transaldolases in the genus Bifidobacterium.	Sgorbati B, Scardovi V.	Antonie Van Leeuwenhoek	10.1007/bf00400786	1979
	Dynamics of bacterial communities during the ripening process of different Croatian cheese types derived from raw ewe's milk cheeses.	Fuka MM, Wallisch S, Engel M, Welzl G, Havranek J, Schloter M.	PLoS One	10.1371/journal.pone.0080734	2013
Metabolism	Genomic characterization and transcriptional studies of the starch-utilizing strain Bifidobacterium adolescentis 22L.	Duranti S, Turroni F, Lugli GA, Milani C, Viappiani A, Mangifesta M, Gioiosa L, Palanza P, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.01993-14	2014
Metabolism	Characterization of two novel alpha-glucosidases from Bifidobacterium breve UCC2003.	Pokusaeva K, O'Connell-Motherway M, Zomer A, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.02391-08	2009
Pathogenicity	The use of biochar in animal feeding.	Schmidt HP, Hagemann N, Draper K, Kammann C.	PeerJ	10.7717/peerj.7373	2019
Metabolism	In vitro fermentation of linear and alpha-1,2-branched dextrans by the human fecal microbiota.	Sarbini SR, Kolida S, Naeye T, Einerhand A, Brison Y, Remaud-Simeon M, Monsan P, Gibson GR, Rastall RA.	Appl Environ Microbiol	10.1128/aem.02568-10	2011
	Genomic diversity and relatedness of bifidobacteria isolated from a porcine cecum.	Simpson PJ, Stanton C, Fitzgerald GF, Ross RP.	J Bacteriol	10.1128/jb.185.8.2571-2581.2003	2003
	Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer.	Wei D, Heus P, van de Wetering FT, van Tienhoven G, Verleye L, Scholten RJ.	Cochrane Database Syst Rev	10.1002/14651858.cd008831.pub3	2018
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
	Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius.	Lai CH, Wu SR, Pang JC, Ramireddy L, Chiang YC, Lin CK, Tsen HY.	J Food Drug Anal	10.1016/j.jfda.2016.10.004	2017
Phylogeny	Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics.	Lugli GA, Milani C, Turroni F, Duranti S, Ferrario C, Viappiani A, Mancabelli L, Mangifesta M, Taminiau B, Delcenserie V, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02004-14	2014
Genetics	Genomic Characteristics of Bifidobacterium thermacidophilum Pig Isolates and Wild Boar Isolates Reveal the Unique Presence of a Putative Mobile Genetic Element with tetW for Pig Farm Isolates.	Tsuchida S, Maruyama F, Ogura Y, Toyoda A, Hayashi T, Okuma M, Ushida K.	Front Microbiol	10.3389/fmicb.2017.01540	2017
	Gene structure and transcriptional organization of the dnaK operon of Bifidobacterium breve UCC 2003 and application of the operon in bifidobacterial tracing.	Ventura M, Zink R, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.71.1.487-500.2005	2005
	Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses.	Ventura M, Canchaya C, Zink R, Fitzgerald GF, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.70.10.6197-6209.2004	2004
	Glycan cross-feeding activities between bifidobacteria under in vitro conditions.	Turroni F, Ozcan E, Milani C, Mancabelli L, Viappiani A, van Sinderen D, Sela DA, Ventura M	Front Microbiol	10.3389/fmicb.2015.01030	2015
Phylogeny	Bifidobacterium apri sp. nov., a thermophilic actinobacterium isolated from the digestive tract of wild pigs (Sus scrofa).	Pechar R, Killer J, Salmonova H, Geigerova M, Svejstil R, Svec P, Sedlacek I, Rada V, Benada O	Int J Syst Evol Microbiol	10.1099/ijsem.0.001956	2017
Phylogeny	Species identification of genus Bifidobacterium based on partial HSP60 gene sequences and proposal of Bifidobacterium thermacidophilum subsp. porcinum subsp. nov.	Zhu L, Li W, Dong X	Int J Syst Evol Microbiol	10.1099/ijs.0.02617-0	2003

References

#8479	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20210
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#39289	; Curators of the CIP;
#52433	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 34983
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#123507	Collection of Institut Pasteur ; Curators of the CIP; CIP 105420
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Bifidobacterium thermophilum (DSM 20210, ATCC 25525, CIP 105420)

Name and taxonomic classification

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