Megamonas hypermegale (DSM 1672, ATCC 25560, DSM 20631)

Name: Megamonas hypermegale (DSM 1672, ATCC 25560, DSM 20631)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 17125

Type strain

Culture col. no. DSM 1672 ATCC 25560 DSM 20631 NCTC 10570 CCUG 5856 2 more

NCBI tax ID(s) 1122216 158847

Special Collections DSMZ CCUG

History DSMZ <- NCTC <- E.M. Barnes, EBF 61/42

Links

Megamonas hypermegale DSM 1672 is an anaerobe bacterium that was isolated from chicken caecum.

anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 3556

LMG 3890,ATCC 25560,CCUG 5856,DSM 1672,NCTC 10570,DSM 20631,VTT E-81135

@ref 20215

Last LPSN update 2026-05-29 08:28:56

Domain Bacteria

Phylum Bacillota

Class Negativicutes

Order Selenomonadales

Family Selenomonadaceae

Genus Megamonas

Species Megamonas hypermegale

Full scientific name Megamonas hypermegale corrig. (Harrison and Hansen 1963) Shah and Collins 1983

Synonyms (2)

Bacteroides hypermegas
Megamonas hypermegas

Morphology

Multimedia

@ref:	66793
multimedia content:	EM_DSM_1672_1.jpg
multimedia.multimedia content:	EM_DSM_1672_1.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

@ref:	66793
multimedia content:	EM_DSM_1672_2.jpg
multimedia.multimedia content:	EM_DSM_1672_2.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

@ref:	66793
multimedia content:	EM_DSM_1672_3.jpg
multimedia.multimedia content:	EM_DSM_1672_3.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

@ref:	66793
multimedia content:	EM_DSM_1672_4.jpg
multimedia.multimedia content:	EM_DSM_1672_4.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

@ref:	66793
multimedia content:	EM_DSM_1672_5.jpg
multimedia.multimedia content:	EM_DSM_1672_5.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
851	CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)		Medium recipe at MediaDive	Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water
851	CHOPPED MEAT MEDIUM (DSMZ Medium 78)		Medium recipe at MediaDive	Name: CHOPPED MEAT MEDIUM (DSMZ Medium 78) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l Ethanol 9.5 g/l (optional) K2HPO4 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl 0.5 g/l Haemin 0.005 g/l (optional) Resazurin 0.001 g/l Vitamin K3 0.0005 g/l (optional) Vitamin K1 (optional) NaOH (optional) Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
851	positive	growth	37
44862	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
851	anaerobe
44862	anaerobe
125438	anaerobe	91.387
125439	facultative anaerobe	92.054

Spore formation

@ref	Spore formation	Confidence
125439		93.876

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68380	16024 ChEBI	D-mannose	+	fermentation	from API rID32A
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68380	16634 ChEBI	raffinose	+	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68380	alpha-galactosidase	+	3.2.1.22	from API rID32A
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	ppGpp biosynthesis	100	4 of 4
66794	suberin monomers biosynthesis	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	biotin biosynthesis	100	4 of 4
66794	palmitate biosynthesis	95.45	21 of 22
66794	pentose phosphate pathway	90.91	10 of 11
66794	threonine metabolism	90	9 of 10
66794	starch degradation	90	9 of 10
66794	chorismate metabolism	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	87.5	7 of 8
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	propanol degradation	85.71	6 of 7
66794	vitamin B1 metabolism	84.62	11 of 13
66794	lipoate biosynthesis	80	4 of 5
66794	cellulose degradation	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	hydrogen production	80	4 of 5
66794	flavin biosynthesis	80	12 of 15
66794	glycogen metabolism	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	serine metabolism	77.78	7 of 9
66794	phenylalanine metabolism	76.92	10 of 13
66794	CMP-KDO biosynthesis	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	acetate fermentation	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	pyrimidine metabolism	73.33	33 of 45
66794	tetrahydrofolate metabolism	71.43	10 of 14
66794	citric acid cycle	71.43	10 of 14
66794	glycolysis	70.59	12 of 17
66794	vitamin B12 metabolism	70.59	24 of 34
66794	propionate fermentation	70	7 of 10
66794	purine metabolism	68.09	64 of 94
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	formaldehyde oxidation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	acetoin degradation	66.67	2 of 3
66794	molybdenum cofactor biosynthesis	66.67	6 of 9
66794	CO2 fixation in Crenarchaeota	66.67	6 of 9
66794	octane oxidation	66.67	2 of 3
66794	lipid A biosynthesis	66.67	6 of 9
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	heme metabolism	64.29	9 of 14
66794	d-xylose degradation	63.64	7 of 11
66794	isoleucine metabolism	62.5	5 of 8
66794	ketogluconate metabolism	62.5	5 of 8
66794	glutamate and glutamine metabolism	60.71	17 of 28
66794	factor 420 biosynthesis	60	3 of 5
66794	alanine metabolism	58.62	17 of 29
66794	non-pathway related	57.89	22 of 38
66794	methionine metabolism	57.69	15 of 26
66794	isoprenoid biosynthesis	57.69	15 of 26
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	degradation of hexoses	55.56	10 of 18
66794	histidine metabolism	55.17	16 of 29
66794	leucine metabolism	53.85	7 of 13
66794	urea cycle	53.85	7 of 13
66794	polyamine pathway	52.17	12 of 23
66794	oxidative phosphorylation	51.65	47 of 91
66794	adipate degradation	50	1 of 2
66794	Entner Doudoroff pathway	50	5 of 10
66794	glycine metabolism	50	5 of 10
66794	degradation of sugar alcohols	50	8 of 16
66794	1,4-dihydroxy-6-naphthoate biosynthesis	50	3 of 6
66794	pantothenate biosynthesis	50	3 of 6
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	ribulose monophosphate pathway	50	1 of 2
66794	degradation of pentoses	50	14 of 28
66794	ethanol fermentation	50	1 of 2
66794	cysteine metabolism	50	9 of 18
66794	arginine metabolism	50	12 of 24
66794	selenocysteine biosynthesis	50	3 of 6
66794	tryptophan metabolism	50	19 of 38
66794	tyrosine metabolism	50	7 of 14
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	metabolism of disaccharids	45.45	5 of 11
66794	proline metabolism	45.45	5 of 11
66794	lysine metabolism	45.24	19 of 42
66794	lipid metabolism	45.16	14 of 31
66794	allantoin degradation	44.44	4 of 9
66794	d-mannose degradation	44.44	4 of 9
66794	cardiolipin biosynthesis	42.86	3 of 7
66794	glutathione metabolism	42.86	6 of 14
66794	O-antigen biosynthesis	40	2 of 5
66794	methylglyoxal degradation	40	2 of 5
66794	vitamin B6 metabolism	36.36	4 of 11
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	sulfoquinovose degradation	33.33	1 of 3
66794	nitrate assimilation	33.33	3 of 9
66794	sphingosine metabolism	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	cyanate degradation	33.33	1 of 3
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	sulfate reduction	30.77	4 of 13
66794	coenzyme M biosynthesis	30	3 of 10
66794	ascorbate metabolism	27.27	6 of 22
66794	dTDPLrhamnose biosynthesis	25	2 of 8
66794	carnitine metabolism	25	2 of 8
66794	lactate fermentation	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	butanoate fermentation	25	1 of 4
66794	catecholamine biosynthesis	25	1 of 4
66794	4-hydroxymandelate degradation	22.22	2 of 9

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
851	-	-	+	+	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Birds	#Chicken
#Host Body-Site	#Gastrointestinal tract	#Large intestine

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
851	chicken caecum
44862	Chicken caecum	Norwich ?	United Kingdom	GBR	Europe

Taxonmaps

69479

Global distribution of 16S sequence AJ420107 (>99% sequence identity) for Megamonas hypermegale subclade from Microbeatlas

Aquatic Samples	452
Soil Samples	192
Animal Samples	4092
Plant Samples	27
Total Samples	4763

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
851	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	50279_G02 assembly for Megamonas hypermegale NCTC10570	complete	GCA_900187035	158847.8	2773858049	158847	99.07
66792	ASM42338v1 assembly for Megamonas hypermegale DSM 1672	scaffold	GCA_000423385	1122216.3	2523533610	1122216	67.59

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Megamonas hypermegale 16S rRNA gene, strain DSM 1672T	AJ420107	1518		158847

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: 50279_G02 assembly for Megamonas hypermegale NCTC10570
BV-BRC: 158847.8

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	92.05	no
125439	motility	BacteriaNetⓘ	no	79.09	no
125439	gram_stain	BacteriaNetⓘ	positive	71.83	no
125439	spore_formation	BacteriaNetⓘ	no	93.88	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Megamonas hypermegale NCTC10570
NCBI: GCA_900187035.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	88.00	no
125438	anaerobic	anaerobicⓘ	yes	91.39	yes
125438	aerobic	aerobicⓘ	no	93.56	yes
125438	spore-forming	spore-formingⓘ	no	81.80	no
125438	thermophilic	thermophileⓘ	no	90.19	yes
125438	flagellated	motile2+ⓘ	no	82.60	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.	Sharma A, Sharma G, Im SH.	Gut Microbes	10.1080/19490976.2025.2516702	2025
	Antibiotic manipulation of intestinal microbiota to identify microbes associated with Campylobacter jejuni exclusion in poultry.	Scupham AJ, Jones JA, Rettedal EA, Weber TE.	Appl Environ Microbiol	10.1128/aem.00678-10	2010
Phylogeny	Megamonas rupellensis sp. nov., an anaerobe isolated from the caecum of a duck.	Chevrot R, Carlotti A, Sopena V, Marchand P, Rosenfeld E	Int J Syst Evol Microbiol	10.1099/ijs.0.2008/001297-0	2008

References

#851	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 1672
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#44862	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 5856
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66793	Mukherjee et al.: GEBA: 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life. 35: 676 - 683 2017 ( DOI 10.1038/nbt.3886 , PubMed 28604660 )
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#68380	Automatically annotated from API rID32A .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

Content

About us

Megamonas hypermegale (DSM 1672, ATCC 25560, DSM 20631)

Name and taxonomic classification

Morphology

Multimedia

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

Pathway annotation

API rID32A

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900187035

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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