Metallosphaera sedula (DSM 5348, ATCC 51363, TH2)

Name: Metallosphaera sedula (DSM 5348, ATCC 51363, TH2)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16645

Type strain

Strain Designation TH2

Culture col. no. DSM 5348 ATCC 51363 TH2

NCBI tax ID(s) 399549 43687

Special Collections DSMZ

Links

Metallosphaera sedula TH2 is a thermophilic prokaryote that was isolated from hot water pond.

thermophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 42950

ATCC 51363,DSM 5348,JCM 9185,IFO 15509,NBRC 15509

@ref 20215

Last LPSN update 2025-12-16 09:50:53

Domain Thermoproteati

Phylum Thermoproteota

Class Thermoprotei

Order Sulfolobales

Family Sulfolobaceae

Genus Metallosphaera

Species Metallosphaera sedula

Full scientific name Metallosphaera sedula Huber et al. 1989

BacDive ID	Other strains from **Metallosphaera sedula** (2)	Type strain
162678	M. sedula JCM 19967
165990	M. sedula JCM 9064, IFO 15160, NBRC 15160

Morphology

Colony morphology

1995

Incubation period3-7 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
1995	SULFOLOBUS MEDIUM (DSMZ Medium 88)		Medium recipe at MediaDive	Name: SULFOLOBUS MEDIUM (DSMZ Medium 88; with strain-specific modifications) Composition: None 19.802 g/l (NH4)2SO4 1.28713 g/l Sulfur powder 0.49505 g/l KH2PO4 0.277228 g/l MgSO4 x 7 H2O 0.247525 g/l CaCl2 x 2 H2O 0.0693069 g/l FeCl3 x 6 H2O 0.019802 g/l Na2B4O7 x 10 H2O 0.00445545 g/l MnCl2 x 4 H2O 0.00178218 g/l ZnSO4 x 7 H2O 0.000217822 g/l CuCl2 x 2 H2O 4.95049e-05 g/l Na2MoO4 x 2 H2O 2.9703e-05 g/l VOSO4 x 2 H2O 2.9703e-05 g/l CoSO4 x 7 H2O 9.90099e-06 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
1995	positive	growth	65	thermophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	anaerobe	99.5

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	ribulose monophosphate pathway	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	adipate degradation	100	2 of 2
66794	valine metabolism	100	9 of 9
66794	ethanol fermentation	100	2 of 2
66794	flavin biosynthesis	93.33	14 of 15
66794	propionate fermentation	90	9 of 10
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	propanol degradation	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	phenylalanine metabolism	84.62	11 of 13
66794	leucine metabolism	84.62	11 of 13
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	gallate degradation	80	4 of 5
66794	Entner Doudoroff pathway	80	8 of 10
66794	methylglyoxal degradation	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	phenylacetate degradation (aerobic)	80	4 of 5
66794	vitamin B12 metabolism	79.41	27 of 34
66794	photosynthesis	78.57	11 of 14
66794	citric acid cycle	78.57	11 of 14
66794	chorismate metabolism	77.78	7 of 9
66794	palmitate biosynthesis	77.27	17 of 22
66794	coenzyme A metabolism	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	acetate fermentation	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	glutamate and glutamine metabolism	75	21 of 28
66794	isoleucine metabolism	75	6 of 8
66794	pentose phosphate pathway	72.73	8 of 11
66794	4-hydroxyphenylacetate degradation	70	7 of 10
66794	methionine metabolism	69.23	18 of 26
66794	vitamin B1 metabolism	69.23	9 of 13
66794	purine metabolism	69.15	65 of 94
66794	alanine metabolism	68.97	20 of 29
66794	serine metabolism	66.67	6 of 9
66794	acetoin degradation	66.67	2 of 3
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	octane oxidation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	pyrimidine metabolism	66.67	30 of 45
66794	formaldehyde oxidation	66.67	2 of 3
66794	arginine metabolism	66.67	16 of 24
66794	cyanate degradation	66.67	2 of 3
66794	glycolysis	64.71	11 of 17
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	NAD metabolism	61.11	11 of 18
66794	lipoate biosynthesis	60	3 of 5
66794	hydrogen production	60	3 of 5
66794	threonine metabolism	60	6 of 10
66794	mevalonate metabolism	57.14	4 of 7
66794	heme metabolism	57.14	8 of 14
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	glutathione metabolism	57.14	8 of 14
66794	cysteine metabolism	55.56	10 of 18
66794	d-mannose degradation	55.56	5 of 9
66794	d-xylose degradation	54.55	6 of 11
66794	isoprenoid biosynthesis	53.85	14 of 26
66794	urea cycle	53.85	7 of 13
66794	sulfate reduction	53.85	7 of 13
66794	non-pathway related	52.63	20 of 38
66794	tryptophan metabolism	52.63	20 of 38
66794	degradation of sugar acids	52	13 of 25
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	coenzyme M biosynthesis	50	5 of 10
66794	selenocysteine biosynthesis	50	3 of 6
66794	lysine metabolism	50	21 of 42
66794	glycine metabolism	50	5 of 10
66794	pantothenate biosynthesis	50	3 of 6
66794	glycogen biosynthesis	50	2 of 4
66794	dTDPLrhamnose biosynthesis	50	4 of 8
66794	butanoate fermentation	50	2 of 4
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	CDP-diacylglycerol biosynthesis	50	1 of 2
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	resorcinol degradation	50	1 of 2
66794	phenylmercury acetate degradation	50	1 of 2
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	lipid metabolism	48.39	15 of 31
66794	histidine metabolism	48.28	14 of 29
66794	polyamine pathway	47.83	11 of 23
66794	carotenoid biosynthesis	45.45	10 of 22
66794	dolichyl-diphosphooligosaccharide biosynthesis	45.45	5 of 11
66794	degradation of hexoses	44.44	8 of 18
66794	degradation of sugar alcohols	43.75	7 of 16
66794	tetrahydrofolate metabolism	42.86	6 of 14
66794	tyrosine metabolism	42.86	6 of 14
66794	ascorbate metabolism	40.91	9 of 22
66794	peptidoglycan biosynthesis	40	6 of 15
66794	3-chlorocatechol degradation	40	2 of 5
66794	degradation of pentoses	39.29	11 of 28
66794	oxidative phosphorylation	38.46	35 of 91
66794	ketogluconate metabolism	37.5	3 of 8
66794	carnitine metabolism	37.5	3 of 8
66794	proline metabolism	36.36	4 of 11
66794	IAA biosynthesis	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	4-hydroxymandelate degradation	33.33	3 of 9
66794	3-phenylpropionate degradation	33.33	5 of 15
66794	sphingosine metabolism	33.33	2 of 6
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	lipid A biosynthesis	33.33	3 of 9
66794	phosphatidylethanolamine bioynthesis	30.77	4 of 13
66794	starch degradation	30	3 of 10
66794	phenol degradation	30	6 of 20
66794	myo-inositol biosynthesis	30	3 of 10
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	cardiolipin biosynthesis	28.57	2 of 7
66794	vitamin B6 metabolism	27.27	3 of 11
66794	ppGpp biosynthesis	25	1 of 4
66794	lactate fermentation	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	biotin biosynthesis	25	1 of 4
66794	CMP-KDO biosynthesis	25	1 of 4
66794	phenylpropanoid biosynthesis	23.08	3 of 13
66794	nitrate assimilation	22.22	2 of 9

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Aquatic	#Pond (small)
#Condition	#Thermophilic (>45°C)	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
1995	hot water pond	Naples, Pisciarelli Solfatara	Italy	ITA	Europe

Taxonmaps

69479

Global distribution of 16S sequence D26491 (>99% sequence identity) for Metallosphaera from Microbeatlas

Aquatic Samples	29
Soil Samples
Animal Samples	1
Plant Samples
Total Samples	30

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
1995	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM1660v1 assembly for Metallosphaera sedula DSM 5348	complete	GCA_000016605	399549.15	640427120	399549	99.35
124043	ASM3561055v1 assembly for Metallosphaera sedula DSM 5348	complete	GCA_035610555			399549	98.29

Genome browser: GCA_000016605

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Metallosphaera sedula 16S rRNA gene complete sequence and 23S rRNA gene 5' region	D26491	2849		399549
20218	M.sedula DNA for 16S ribosomal RNA gene	X90481	1416		399549

GC content

1995

GC-content (mol%)45.0

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Metallosphaera sedula DSM 5348
PATRIC: 399549.15

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	80.00	no
125439	motility	BacteriaNetⓘ	yes	64.70	no
125439	gram_stain	BacteriaNetⓘ	variable	78.70	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.50	no

Literature

Title	Authors	Journal	DOI	Year
Complete genome sequence for the thermoacidophilic archaeon Metallosphaera sedula (DSM:5348).	Manesh MJH, Bing RG, Willard DJ, Kelly RM.	Microbiol Resour Announc	10.1128/mra.01228-23	2024
Improved protocol for metabolite extraction and identification of respiratory quinones in extremophilic Archaea grown on mineral materials.	Gfellner SV, Colas C, Gabant G, Groninga J, Cadene M, Milojevic T.	Front Microbiol	10.3389/fmicb.2024.1473270	2024
Development of a defined medium for the heterotrophic cultivation of Metallosphaera sedula.	Sedlmayr VL, Luger M, Pittenauer E, Marchetti-Deschmann M, Kronlachner L, Limbeck A, Raunjak P, Quehenberger J, Spadiut O.	Extremophiles	10.1007/s00792-024-01348-0	2024
Control of the archaeal DNA damage-responsive pathway by phosphorylation of Orc1-2, the global regulator in Saccharolobus islandicus.	Liu X, Feng X, Yuan G, Wang F, Huang Q, Xu J, Shen Y, She Q.	Nucleic Acids Res	10.1093/nar/gkaf927	2025
Chalcopyrite bioleaching efficacy by extremely thermoacidophilic archaea leverages balanced iron and sulfur biooxidation.	Manesh MJH, Willard DJ, John KM, Kelly RM.	Bioresour Technol	10.1016/j.biortech.2024.131198	2024
Isolation of Thermophilic Bacteria and Investigation of Their Microplastic Degradation Ability Using Polyethylene Polymers.	Ozdemir S, Akarsu C, Acer O, Fouillaud M, Dufosse L, Dizge N.	Microorganisms	10.3390/microorganisms10122441	2022
Two enzymes contribute to citrate production in the mitochondrion of Toxoplasma gondii.	Lyu C, Meng Y, Zhang X, Yang J, Shen B.	J Biol Chem	10.1016/j.jbc.2024.107565	2024
Complete Genome Sequences of Evolved Arsenate-Resistant Metallosphaera sedula Strains.	Ai C, McCarthy S, Schackwitz W, Martin J, Lipzen A, Blum P.	Genome Announc	10.1128/genomea.01142-15	2015
Comparative Genomic Analysis Reveals the Metabolism and Evolution of the Thermophilic Archaeal Genus Metallosphaera.	Wang P, Li LZ, Qin YL, Liang ZL, Li XT, Yin HQ, Liu LJ, Liu SJ, Jiang CY.	Front Microbiol	10.3389/fmicb.2020.01192	2020
New virus isolates from Italian hydrothermal environments underscore the biogeographic pattern in archaeal virus communities.	Baquero DP, Contursi P, Piochi M, Bartolucci S, Liu Y, Cvirkaite-Krupovic V, Prangishvili D, Krupovic M.	ISME J	10.1038/s41396-020-0653-z	2020
Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO₂ Fixation in Metallosphaera sedula.	Liu L, Huber H, Berg IA.	Front Microbiol	10.3389/fmicb.2020.00354	2020
Convergent Evolution of a Promiscuous 3-Hydroxypropionyl-CoA Dehydratase/Crotonyl-CoA Hydratase in Crenarchaeota and Thaumarchaeota.	Liu L, Brown PC, Konneke M, Huber H, Konig S, Berg IA.	mSphere	10.1128/msphere.01079-20	2021
(S)-3-Hydroxybutyryl-CoA Dehydrogenase From the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Nitrosopumilus maritimus.	Liu L, Schubert DM, Konneke M, Berg IA.	Front Microbiol	10.3389/fmicb.2021.712030	2021
Phenotype-driven assessment of the ancestral trajectory of sulfur biooxidation in the thermoacidophilic archaea Sulfolobaceae.	Willard DJ, H Manesh MJ, Bing RG, Alexander BH, Kelly RM.	mBio	10.1128/mbio.01033-24	2024
Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula.	Ye Z, Li X, Cheng Y, Liu Z, Tan G, Zhu F, Fu S, Deng Z, Liu T.	J Ind Microbiol Biotechnol	10.1007/s10295-016-1793-z	2016
Role of an archaeal PitA transporter in the copper and arsenic resistance of Metallosphaera sedula, an extreme thermoacidophile.	McCarthy S, Ai C, Wheaton G, Tevatia R, Eckrich V, Kelly R, Blum P.	J Bacteriol	10.1128/jb.01707-14	2014
Epimerase (Msed_0639) and mutase (Msed_0638 and Msed_2055) convert (S)-methylmalonyl-coenzyme A (CoA) to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle.	Han Y, Hawkins AS, Adams MW, Adams MW, Kelly RM.	Appl Environ Microbiol	10.1128/aem.01312-12	2012
Biochemical and Structural Properties of a Thermostable Mercuric Ion Reductase from Metallosphaera sedula.	Artz JH, White SN, Zadvornyy OA, Fugate CJ, Hicks D, Gauss GH, Posewitz MC, Boyd ES, Peters JW.	Front Bioeng Biotechnol	10.3389/fbioe.2015.00097	2015
A Novel Gene Cluster Is Involved in the Degradation of Lignin-Derived Monoaromatics in Thermus oshimai JL-2.	Chakraborty J, Suzuki-Minakuchi C, Tomita T, Okada K, Nojiri H.	Appl Environ Microbiol	10.1128/aem.01589-20	2021
Candidatus Nitrosocaldus cavascurensis, an Ammonia Oxidizing, Extremely Thermophilic Archaeon with a Highly Mobile Genome.	Abby SS, Melcher M, Kerou M, Krupovic M, Stieglmeier M, Rossel C, Pfeifer K, Schleper C.	Front Microbiol	10.3389/fmicb.2018.00028	2018
Exploring short k-mer profiles in cells and mobile elements from Archaea highlights the major influence of both the ecological niche and evolutionary history.	Bize A, Midoux C, Mariadassou M, Schbath S, Forterre P, Da Cunha V.	BMC Genomics	10.1186/s12864-021-07471-y	2021
Genome Sequencing of Sulfolobus sp. A20 from Costa Rica and Comparative Analyses of the Putative Pathways of Carbon, Nitrogen, and Sulfur Metabolism in Various Sulfolobus Strains.	Dai X, Wang H, Zhang Z, Li K, Zhang X, Mora-Lopez M, Jiang C, Liu C, Wang L, Zhu Y, Hernandez-Ascencio W, Dong Z, Huang L.	Front Microbiol	10.3389/fmicb.2016.01902	2016
Evidence of carbon fixation pathway in a bacterium from candidate phylum SBR1093 revealed with genomic analysis.	Wang Z, Guo F, Liu L, Zhang T.	PLoS One	10.1371/journal.pone.0109571	2014
The Comparatively Proteomic Analysis in Response to Cold Stress in Cassava Plantlets.	An F, Li G, Li QX, Li K, Carvalho LJ, Ou W, Chen S.	Plant Mol Biol Report	10.1007/s11105-016-0987-x	2016
Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO₂ fixation cycle in extremely thermoacidophilic archaea.	Loder AJ, Han Y, Hawkins AB, Lian H, Lipscomb GL, Schut GJ, Keller MW, Adams MWW, Kelly RM.	Metab Eng	10.1016/j.ymben.2016.10.009	2016
Metabolic characteristics of dominant microbes and key rare species from an acidic hot spring in Taiwan revealed by metagenomics.	Lin KH, Liao BY, Chang HW, Huang SW, Chang TY, Yang CY, Wang YB, Lin YT, Wu YW, Tang SL, Yu HT.	BMC Genomics	10.1186/s12864-015-2230-9	2015
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.	Alber BE, Kung JW, Fuchs G.	J Bacteriol	10.1128/jb.01593-07	2008
Labeling and enzyme studies of the central carbon metabolism in Metallosphaera sedula.	Estelmann S, Hugler M, Eisenreich W, Werner K, Berg IA, Ramos-Vera WH, Say RF, Kockelkorn D, Gad'on N, Fuchs G.	J Bacteriol	10.1128/jb.01155-10	2011
Metagenomic sequencing of marine periphyton: taxonomic and functional insights into biofilm communities.	Sanli K, Bengtsson-Palme J, Nilsson RH, Kristiansson E, Alm Rosenblad M, Blanck H, Eriksson KM.	Front Microbiol	10.3389/fmicb.2015.01192	2015
Thiosulfate transfer mediated by DsrE/TusA homologs from acidothermophilic sulfur-oxidizing archaeon Metallosphaera cuprina.	Liu LJ, Stockdreher Y, Koch T, Sun ST, Fan Z, Josten M, Sahl HG, Wang Q, Luo YM, Liu SJ, Dahl C, Jiang CY.	J Biol Chem	10.1074/jbc.m114.591669	2014
Exploiting microbial hyperthermophilicity to produce an industrial chemical, using hydrogen and carbon dioxide.	Keller MW, Schut GJ, Lipscomb GL, Menon AL, Iwuchukwu IJ, Leuko TT, Thorgersen MP, Nixon WJ, Hawkins AS, Kelly RM, Adams MW, Adams MW.	Proc Natl Acad Sci U S A	10.1073/pnas.1222607110	2013
Sulfur Metabolism Pathways in Sulfobacillus acidophilus TPY, A Gram-Positive Moderate Thermoacidophile from a Hydrothermal Vent.	Guo W, Zhang H, Zhou W, Wang Y, Zhou H, Chen X.	Front Microbiol	10.3389/fmicb.2016.01861	2016
Novel Transcriptional Regulons for Autotrophic Cycle Genes in Crenarchaeota.	Leyn SA, Rodionova IA, Li X, Rodionov DA.	J Bacteriol	10.1128/jb.00249-15	2015
Phylogeny and Taxonomy of Archaea: A Comparison of the Whole-Genome-Based CVTree Approach with 16S rRNA Sequence Analysis.	Zuo G, Xu Z, Hao B.	Life (Basel)	10.3390/life5010949	2015
Acidianus Tailed Spindle Virus: a New Archaeal Large Tailed Spindle Virus Discovered by Culture-Independent Methods.	Hochstein RA, Amenabar MJ, Munson-McGee JH, Boyd ES, Young MJ.	J Virol	10.1128/jvi.03098-15	2016
Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales.	Kockelkorn D, Fuchs G.	J Bacteriol	10.1128/jb.00794-09	2009
Sequence evidence in the archaeal genomes that tRNAs emerged through the combination of ancestral genes as 5' and 3' tRNA halves.	Fujishima K, Sugahara J, Tomita M, Kanai A.	PLoS One	10.1371/journal.pone.0001622	2008
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.	Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G.	J Bacteriol	10.1128/jb.01156-10	2011
Genomics against flatulence.	Galperin MY.	Environ Microbiol	10.1111/j.1462-2920.2007.01400.x	2007
Dark matter in archaeal genomes: a rich source of novel mobile elements, defense systems and secretory complexes.	Makarova KS, Wolf YI, Forterre P, Prangishvili D, Krupovic M, Koonin EV.	Extremophiles	10.1007/s00792-014-0672-7	2014
Identification and genomic analysis of transcription factors in archaeal genomes exemplifies their functional architecture and evolutionary origin.	Perez-Rueda E, Janga SC.	Mol Biol Evol	10.1093/molbev/msq033	2010
Archaeal ubiquitin-like proteins: functional versatility and putative ancestral involvement in tRNA modification revealed by comparative genomic analysis.	Makarova KS, Koonin EV.	Archaea	10.1155/2010/710303	2010
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.	Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G.	J Bacteriol	10.1128/jb.00987-06	2006
The archaeal Ced system imports DNA.	van Wolferen M, Wagner A, van der Does C, Albers SV.	Proc Natl Acad Sci U S A	10.1073/pnas.1513740113	2016
Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function.	Inskeep WP, Rusch DB, Jay ZJ, Herrgard MJ, Kozubal MA, Richardson TH, Macur RE, Hamamura N, Jennings Rd, Fouke BW, Reysenbach AL, Roberto F, Young M, Schwartz A, Boyd ES, Badger JH, Mathur EJ, Ortmann AC, Bateson M, Geesey G, Frazier M.	PLoS One	10.1371/journal.pone.0009773	2010
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.	Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G.	J Bacteriol	10.1128/jb.00068-09	2009
Heavily Armed Ancestors: CRISPR Immunity and Applications in Archaea with a Comparative Analysis of CRISPR Types in Sulfolobales.	Zink IA, Wimmer E, Schleper C.	Biomolecules	10.3390/biom10111523	2020
A study in entire chromosomes of violations of the intra-strand parity of complementary nucleotides (Chargaff's second parity rule).	Powdel BR, Satapathy SS, Kumar A, Jha PK, Buragohain AK, Borah M, Ray SK.	DNA Res	10.1093/dnares/dsp021	2009
Whole-genome based Archaea phylogeny and taxonomy: A composition vector approach.	Sun J, Xu Z, Hao B.	Chin Sci Bull	10.1007/s11434-010-3008-8	2010
An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea.	Atkinson GC, Hauryliuk V, Tenson T.	BMC Evol Biol	10.1186/1471-2148-11-22	2011
Proteomic analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus infection.	Maaty WS, Selvig K, Ryder S, Tarlykov P, Hilmer JK, Heinemann J, Steffens J, Snyder JC, Ortmann AC, Movahed N, Spicka K, Chetia L, Grieco PA, Dratz EA, Douglas T, Young MJ, Bothner B.	J Proteome Res	10.1021/pr201087v	2012
Functional promiscuity of the COG0720 family.	Phillips G, Grochowski LL, Bonnett S, Xu H, Bailly M, Blaby-Haas C, El Yacoubi B, Iwata-Reuyl D, White RH, de Crecy-Lagard V.	ACS Chem Biol	10.1021/cb200329f	2012
Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities.	Toesch M, Schober M, Faber K.	Appl Microbiol Biotechnol	10.1007/s00253-013-5438-0	2014
Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system.	Vestergaard G, Shah SA, Bize A, Reitberger W, Reuter M, Phan H, Briegel A, Rachel R, Garrett RA, Prangishvili D.	J Bacteriol	10.1128/jb.00795-08	2008
Bioenergetic Response of the Extreme Thermoacidophile Metallosphaera sedula to Thermal and Nutritional Stresses.	Peeples TL, Kelly RM.	Appl Environ Microbiol	10.1128/aem.61.6.2314-2321.1995	1995
Archaeal RNA polymerase and transcription regulation.	Jun SH, Reichlen MJ, Tajiri M, Murakami KS.	Crit Rev Biochem Mol Biol	10.3109/10409238.2010.538662	2011
Algorithms of ancestral gene length reconstruction.	Bolshoy A, Kirzhner VM.	Biomed Res Int	10.1155/2013/472163	2013
A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.	Storbeck S, Rolfes S, Raux-Deery E, Warren MJ, Jahn D, Layer G.	Archaea	10.1155/2010/175050	2010
Reverse gyrase, a hallmark of the hyperthermophilic archaebacteria.	Bouthier de la Tour C, Portemer C, Nadal M, Stetter KO, Forterre P, Duguet M.	J Bacteriol	10.1128/jb.172.12.6803-6808.1990	1990
Information theoretic perspective on genome clustering.	Veluchamy A, Mehta P, Srividhya KV, Vikram H, Govind MK, Gupta R, Aziz Bin Dukhyil A, Abdullah Alharbi R, Abdullah Aloyuni S, Hassan MM, Krishnaswamy S.	Saudi J Biol Sci	10.1016/j.sjbs.2020.12.039	2021
Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation.	Menendez C, Bauer Z, Huber H, Gad'on N, Stetter KO, Fuchs G.	J Bacteriol	10.1128/jb.181.4.1088-1098.1999	1999
Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Organic solutes in hyperthermophilic archaea.	Martins LO, Huber R, Huber H, Stetter KO, Da Costa MS, Santos H.	Appl Environ Microbiol	10.1128/aem.63.3.896-902.1997	1997
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.	Reher M, Fuhrer T, Bott M, Schonheit P.	J Bacteriol	10.1128/jb.01281-09	2010
Diversity, abundance, and activity of archaeal populations in oil-contaminated groundwater accumulated at the bottom of an underground crude oil storage cavity.	Watanabe K, Kodama Y, Hamamura N, Kaku N.	Appl Environ Microbiol	10.1128/aem.68.8.3899-3907.2002	2002
Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family.	Silverio AL, Saier MH.	J Membr Biol	10.1007/s00232-011-9364-8	2011
Cohesion group approach for evolutionary analysis of aspartokinase, an enzyme that feeds a branched network of many biochemical pathways.	Lo CC, Bonner CA, Xie G, D'Souza M, Jensen RA.	Microbiol Mol Biol Rev	10.1128/mmbr.00024-09	2009
Bioleaching genomics.	Siezen RJ, Wilson G.	Microb Biotechnol	10.1111/j.1751-7915.2009.00108.x	2009
Identified Hybrid tRNA Structure Genes in Archaeal Genome.	Mandal UR, Das SS, Chattopadhyay B, Sahoo S	Iran J Biotechnol	10.29252/ijb.2254	2019
The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism.	Auernik KS, Maezato Y, Blum PH, Kelly RM	Appl Environ Microbiol	10.1128/AEM.02019-07	2007
Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like Transporters May Be Involved in Copper Resistance in Metallosphaera sedula DSM 5348(T).	Rivero M, Torres-Paris C, Munoz R, Cabrera R, Navarro CA, Jerez CA	Archaea	10.1155/2018/5251061	2018
Metallosphaera sedula TA-2, a calditoglycerocaldarchaeol deletion strain of a thermoacidophilic archaeon.	Itoh YH, Kurosawa N, Uda I, Sugai A, Tanoue S, Itoh T, Horiuchi T, Itoh T	Extremophiles	10.1007/s007920100195	2001
Intestinibaculum porci gen. nov., sp. nov., a new member of the family Erysipelotrichaceae isolated from the small intestine of a swine.	Kim JS, Choe H, Lee YR, Kim KM, Park DS.	J Microbiol	10.1007/s12275-019-8631-8	2019
Metallosphaera cuprina sp. nov., an acidothermophilic, metal-mobilizing archaeon.	Liu LJ, You XY, Guo X, Liu SJ, Jiang CY	Int J Syst Evol Microbiol	10.1099/ijs.0.026591-0	2010

References

#1995	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 5348
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Metallosphaera sedula (DSM 5348, ATCC 51363, TH2)

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