Name: Streptomyces hygroscopicus SF-1293
Creator: BacDive
License: https://creativecommons.org/licenses/by/4.0/

Strain identifier

BacDive ID: 15315

Type strain:

Species: Streptomyces hygroscopicus

Strain Designation: SF-1293

Culture col. no.: DSM 41527, ATCC 21705, CIP 107674, KCTC 9030

Strain history: CIP <- 2002, ATCC <- Meiji Seika Kaisha Ltd: strain SF-1293

NCBI tax ID(s): 1912 (species)

SI-ID 37682

ATCC 21705, KCTC 9030, CIP 107674, KACC 20080, DSM 41527

Special Collections

Other strains from Streptomyces hygroscopicus

Section

Streptomyces hygroscopicus SF-1293 is an obligate aerobe, Gram-positive, rod-shaped bacterium of the family Streptomycetaceae.

Gram-positive
rod-shaped
obligate aerobe
Bacteria

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Kitasatosporales*
	Family	*Streptomycetaceae*
	Genus	*Streptomyces*
	Species	**Streptomyces hygroscopicus**
	Full Scientific Name (LPSN)	Streptomyces hygroscopicus (Jensen 1931) Yüntsen et al. 1956 (Approved Lists 1980)

	Synonym	"Actinomyces* hygroscopicus"*
	Synonym	Streptomyces hygroscopicus subsp. sporocinereus
	Synonym	Streptomyces sporocinereus
	Synonym	Streptomyces endus

Information on morphological and physiological properties Morphology

[Ref.: #120014]	Gram stain	positive

[Ref.: #120014]	Cell shape	rod-shaped

[Ref.: #120014]	Motility	no

Multimedia content

[Ref.: #10376]

Caption:

Medium 84 28°C

[Ref.: #10376]

Intellectual property rights:

Information on culture and growth conditions Culture and growth conditions

[Ref.: #34660]

Culture medium

MEDIUM 128 - for Nocardia brevicatena, Nocardia flavorosea subsp. fusca and Streptomyces ambofaciens

[Ref.: #34660]

Culture medium growth

[Ref.: #34660]

Culture medium composition

expand / minimize

[Ref.: #120014]

Culture medium

CIP Medium 129

[Ref.: #120014]

Culture medium growth

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Culture medium link

Medium recipe provided by DSMZ

	Kind of temperature		Temperature
[Ref.: #34660]		growth	25 °C
[Ref.: #120014]		growth	25-37 °C
[Ref.: #120014]	no	growth	10 °C
[Ref.: #120014]	no	growth	41 °C
[Ref.: #120014]	no	growth	45 °C

Information on physiology and metabolism Physiology and metabolism

[Ref.: #120014]

Oxygen tolerance

obligate aerobe

[Ref.: #10376]

Name of produced compound

antifungal antibiotic SF-1293

	Salt	Tested relation		Salt conc.
[Ref.: #120014]	NaCl		growth	0	%
[Ref.: #120014]	NaCl	no	growth	2	%
[Ref.: #120014]	NaCl	no	growth	4	%
[Ref.: #120014]	NaCl	no	growth	6	%
[Ref.: #120014]	NaCl	no	growth	8	%
[Ref.: #120014]	NaCl	no	growth	10	%

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #120014]	citrate ChEBI	-	carbon source
[Ref.: #120014]	esculin ChEBI	-	hydrolysis
[Ref.: #120014]	hippurate ChEBI	+	hydrolysis
[Ref.: #120014]	nitrate ChEBI	-	reduction
[Ref.: #120014]	nitrate ChEBI	-	respiration
[Ref.: #120014]	nitrite ChEBI	-	reduction

	Antibiotica	Metabolite	Antibiotic sensitivity	Antibiotic resistance
[Ref.: #120014]		0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)	yes	no

	Metabolite production	Metabolite	Production
[Ref.: #120014]		indole ChEBI	no

	Physiological tests	Metabolite	Voges-Proskauer-test	Methylred-test
[Ref.: #120014]		acetoin ChEBI	-
[Ref.: #120014]		glucose ChEBI		+

	Enzyme	Enzyme activity	EC number
[Ref.: #68382]	acid phosphatase	+	3.1.3.2	* from API zym
[Ref.: #120014]	alcohol dehydrogenase	-	1.1.1.1
[Ref.: #68382]	alkaline phosphatase	+	3.1.3.1	* from API zym
[Ref.: #68382]	alpha-chymotrypsin	-	3.4.21.1	* from API zym
[Ref.: #68382]	alpha-fucosidase	-	3.2.1.51	* from API zym
[Ref.: #68382]	alpha-galactosidase	-	3.2.1.22	* from API zym
[Ref.: #68382]	alpha-glucosidase	-	3.2.1.20	* from API zym
[Ref.: #68382]	alpha-mannosidase	-	3.2.1.24	* from API zym
[Ref.: #120014]	amylase	+
[Ref.: #120014]	beta-galactosidase	+	3.2.1.23
[Ref.: #68382]	beta-galactosidase	-	3.2.1.23	* from API zym
[Ref.: #68382]	beta-glucosidase	-	3.2.1.21	* from API zym
[Ref.: #68382]	beta-glucuronidase	-	3.2.1.31	* from API zym
[Ref.: #120014]	caseinase	-	3.4.21.50
[Ref.: #120014]	catalase	+	1.11.1.6
[Ref.: #68382]	cystine arylamidase	-	3.4.11.3	* from API zym
[Ref.: #120014]	DNase	+
[Ref.: #68382]	esterase (C 4)	-		* from API zym
[Ref.: #68382]	esterase lipase (C 8)	-		* from API zym
[Ref.: #120014]	gamma-glutamyltransferase	+	2.3.2.2
[Ref.: #120014]	gelatinase	-
[Ref.: #120014]	lecithinase	+
[Ref.: #68382]	leucine arylamidase	+	3.4.11.1	* from API zym
[Ref.: #120014]	lipase	+
[Ref.: #68382]	lipase (C 14)	-		* from API zym
[Ref.: #120014]	lysine decarboxylase	-	4.1.1.18
[Ref.: #68382]	N-acetyl-beta-glucosaminidase	+	3.2.1.52	* from API zym
[Ref.: #68382]	naphthol-AS-BI-phosphohydrolase	+		* from API zym
[Ref.: #120014]	ornithine decarboxylase	-	4.1.1.17
[Ref.: #120014]	oxidase	-
[Ref.: #120014]	phenylalanine ammonia-lyase	-	4.3.1.24
[Ref.: #120014]	protease	+
[Ref.: #68382]	trypsin	-	3.4.21.4	* from API zym
[Ref.: #120014]	tryptophan deaminase	-
[Ref.: #120014]	tween esterase	+
[Ref.: #120014]	urease	-	3.5.1.5
[Ref.: #68382]	valine arylamidase	-		* from API zym
	Only first 10 entries are displayed. Click here to see all.

API® Biotype100:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
[Ref.: #120014]	2371	not determinedn.d.	+	-	+	+	+	-	+	-	+	+	+	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	+	-	-	-	-	+	-	-	-	+	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	+	-	+	-	-	-	+	+	-	-	-	+	-	-	-	+	+	+	+	+	+	+	-	-	+	-

API® zym:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Control	2-naphthyl phosphateAlkaline phosphatase	2-naphthyl butyrateEsterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	2-naphthyl myristateLipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	N-benzoyl-DL-arginine-2-naphthylamideTrypsin	N-glutaryl-phenylalanine-2-naphthylamidealpha- Chymotrypsin	2-naphthyl phosphateAcid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	6-Br-2-naphthyl-alphaD-galactpyranosidealpha- Galactosidase	2-naphthyl-betaD-galactpyranosidebeta- Galactosidase	Naphthol-AS-BI-betaD-glucuronidebeta- Glucuronidase	2-naphthyl-alphaD-glucopyranosidealpha- Glucosidase	6-Br-2-naphthyl-betaD-glucopyranosidebeta- Glucosidase	1-naphthyl-N-acetyl-betaD-glucosaminideN-acetyl-beta- glucosaminidase	6-Br-2-naphthyl-alphaD-mannopyranosidealpha- Mannosidase	2-naphthyl-alphaL-fucopyranosidealpha- Fucosidase
[Ref.: #120014]	10555	-	+	-	-	-	+	-	-	-	-	+	+	-	-	-	-	-	+	-	-

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #10376]	Biosafety level	1	Risk group (German classification) According to TRBA 466
[Ref.: #120014]	Biosafety level	1	Risk group (French classification)

Availability in culture collections External links

[Ref.: #10376]

Culture collection no.

DSM 41527, ATCC 21705, CIP 107674, KCTC 9030

[Ref.: #84407]

SI-ID 37682

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Genetics	Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.	Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW	Nat Chem Biol	10.1038/nchembio.2007.9	2007	*
Metabolism	[Molecular-genetic study of the functional role of the regulatory gene brpB of the bialaphos producer Streptomyces hygroscopicus ATCC21705].	Tabakov VIu, Tokmakova IL, Voeikova TA	Genetika		1994	*
Enzymology	[Chromosomal determinant of Streptomyces hygroscopicus with positive influence on resistance to bialaphos controlled by the bar gene].	Tabakov VIu, Tokmakova IL, Sezonov GV	Antibiot Khimioter		1992	*
Metabolism	Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme.	Kamigiri K, Hidaka T, Imai S, Murakami T, Seto H	J Antibiot (Tokyo)	10.7164/antibiotics.45.781	1992	*
Enzymology	Purification and characterization of citrate synthase from Streptomyces hygroscopicus SF-1293 and comparison of its properties with those of 2-phosphinomethylmalic acid synthase.	Shimotohno KW, Imai S, Murakami T, Seto H	Agric Biol Chem		1990	*
Enzymology	Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293.	Shimotohno KW, Seto H, Otake N, Imai S, Murakami T	J Antibiot (Tokyo)	10.7164/antibiotics.41.1057	1988	*
Biotechnology	Studies on the biosynthesis of bialaphos (SF-1293) Part 3. Production of phosphinic acid derivatives, MP-103, MP-104 and MP-105, by a blocked mutant of Streptomyces hygroscopicus SF-1293 and their roles in the biosynthesis of bialaphos.	Seto H, Imai S, Tsuruoka T, Ogawa H, Satoh A, Sasaki T, Otake N	Biochem Biophys Res Commun	10.1016/0006-291x(83)91400-6	1983	*

References

#10376

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 41527

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#34660 ; Curators of the CIP;

#68382

Automatically annotated from API zym .

#84407

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID37682.1 )

#120014 Collection of Institut Pasteur ; Curators of the CIP; CIP 107674
* These data were automatically processed and therefore are not curated

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