Streptomyces griseoflavus (DSM 40456, ATCC 25456, CBS 409.52)

Cell morphology

Multimedia

• @ref:	9556
  multimedia content:	DSM_40456.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40456.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9556	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9556	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
18593	22599 ChEBI	arabinose	+
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
18593	28757 ChEBI	fructose	+
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
18593	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	-	degradation	from API 20E
18593	29864 ChEBI	mannitol	+
18593	17268 ChEBI	myo-inositol	+
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
18593	16634 ChEBI	raffinose	+
18593	26546 ChEBI	rhamnose	+
18593	17992 ChEBI	sucrose	+
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	-	hydrolysis	from API 20E
18593	18222 ChEBI	xylose	+

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	-		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68368	gelatinase	+		from API 20E
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
68368	tryptophan deaminase	+	4.1.99.1	from API 20E
68368	urease	-	3.5.1.5	from API 20E

API 20E

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence AB184274 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	0
Soil Samples	30
Animal Samples	18
Plant Samples	2
Total Samples	50

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM1464999v1 assembly for Streptomyces griseoflavus JCM 4479	scaffold	GCA_014649995	35619.5	2997579778	35619	49.33

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces griseoflavus strain JCM 4479 16S ribosomal RNA gene, partial sequence	AY999772	1413		35619
20218	Streptomyces griseoflavus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4479	D44174	121		35619
20218	Streptomyces griseoflavus 16S rRNA gene, type strain LMG 19344	AJ781322	1478		35619
20218	Streptomyces griseoflavus gene for 16S rRNA, partial sequence, strain: NBRC 12372	AB184086	1463		35619
20218	Streptomyces griseoflavus gene for 16S rRNA, partial sequence, strain: NBRC 13044	AB184274	1463		35619
124043	Streptomyces griseoflavus strain JCM 4479 16S ribosomal RNA gene, partial sequence.	MT760553	1371		35619
124043	Streptomyces griseoflavus strain NBRC 13044 16S ribosomal RNA gene, partial sequence.	KU720585	882		35619

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Analysis of the A549 cell line affected by anticancer bioactive compounds of Actinomycetes isolated from saline soils.	Khoshakhlagh A, Abroun S, Aghaei SS, Soleimani M, Zolfaghari MR.	Arch Microbiol	10.1007/s00203-022-03258-1	2022
Genetics	Comparative metagenomic analysis of the oral microbiome in COVID-19 patients and healthy individuals.	Bhanu P, Buchke S, Hemandhar-Kumar N, Varsha P, Kiran SKR, Vikneswaran G, Alva A, Basavaraj GS, Kumar J.	Sci Rep	10.1038/s41598-024-81864-3	2025
	The role of positive charged residue in the proton-transfer mechanism of two-domain laccase from Streptomyces griseoflavus Ac-993.	Gabdulkhakov A, Kolyadenko I, Oliveira P, Tamagnini P, Mikhaylina A, Tishchenko S.	J Biomol Struct Dyn	10.1080/07391102.2021.1911852	2022
	Impact of altitudinal variations on plant growth dynamics, nutritional composition, and free living rhizospheric N2 fixing bacterial community of Eruca sativa.	Kumar N, Kaur B, Sharma D, Korpole S, Shukla S, Bhardwaj P, Patel MK, Acharya S, Khatri M, Saxena S.	Sci Rep	10.1038/s41598-025-98242-2	2025
Genetics	Genomic and Metabolomic Insights into Metabolites of a Streptomyces Isolate Associated with Chromodoris quadricolor, a Red Sea Nudibranch.	Abdelrahman SM, Pratte ZA, El Samak M, Dosoky NS, Hanora AMS, Stewart FJ, Lopanik NB.	Mar Drugs	10.3390/md23100404	2025
	Investigation of diverse biosynthetic secondary metabolites gene clusters using genome mining of indigenous Streptomyces strains isolated from saline soils in Iran.	Khoshakhlagh A, Aghaei SS, Abroun S, Soleimani M, Zolfaghari MR.	Iran J Microbiol	10.18502/ijm.v14i6.11263	2022
	Structural Insight into the Amino Acid Environment of the Two-Domain Laccase's Trinuclear Copper Cluster.	Kolyadenko I, Tishchenko S, Gabdulkhakov A.	Int J Mol Sci	10.3390/ijms241511909	2023
	[Incorporation of Copper Ions into T2/T3 Centers of Two-Domain Laccases].	Gabdulkhakov AG, Kostareva OS, Kolyadenko IA, Mikhaylina AO, Trubitsina LI, Tishchenko SV.	Mol Biol (Mosk)	10.7868/s0026898418010056	2018
Metabolism	Engineering the Catalytic Properties of Two-Domain Laccase from Streptomyces griseoflavus Ac-993.	Kolyadenko I, Scherbakova A, Kovalev K, Gabdulkhakov A, Tishchenko S.	Int J Mol Sci	10.3390/ijms23010065	2021
	Tunicamycins from Marine-Derived Streptomyces bacillaris Inhibit MurNAc-Pentapeptide Translocase in Staphylococcus aureus.	Lee J, Hwang JY, Oh D, Oh DC, Park HG, Shin J, Oh KB.	Mar Drugs	10.3390/md22070293	2024
	Impact of antagonistic endophytic bacteria on productivity of some economically important legumes.	Badawy AM, Badawy AM.	Braz J Microbiol	10.1007/s42770-023-01204-x	2024
Genetics	Whole-genome sequencing-based characterization of Streptomyces sp. 6(4): focus on natural product.	Borba MP, Witusk JP, Cunha DM, de Lima-Morales D, Martins AF, Van Der Sand S.	Access Microbiol	10.1099/acmi.0.000466.v3	2023
Enzymology	Crystallization and X-ray diffraction studies of a two-domain laccase from Streptomyces griseoflavus.	Tishchenko S, Gabdulkhakov A, Trubitsina L, Lisov A, Zakharova M, Leontievsky A.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x15014375	2015
	iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments.	Dos Santos JDN, Joao SA, Martin J, Vicente F, Reyes F, Lage OM.	Microorganisms	10.3390/microorganisms10071471	2022
	Streptomycetaceae and Promicromonosporaceae: Two Actinomycetes Families from Moroccan Oat Soils Enhancing Solubilization of Natural Phosphate.	Bousselham M, Lemriss S, Dhiba D, Aallam Y, Souiri A, Abbas Y, Saidi N, Boukcim H, Hamdali H.	Microorganisms	10.3390/microorganisms10061116	2022
Metabolism	Investigations of Accessibility of T2/T3 Copper Center of Two-Domain Laccase from Streptomyces griseoflavus Ac-993.	Gabdulkhakov A, Kolyadenko I, Kostareva O, Mikhaylina A, Oliveira P, Tamagnini P, Lisov A, Tishchenko S.	Int J Mol Sci	10.3390/ijms20133184	2019
	Improvement of aflatoxin B1 degradation ability by Bacillus licheniformis CotA-laccase Q441A mutant.	Liu Y, Guo Y, Liu L, Tang Y, Wang Y, Ma Q, Zhao L.	Heliyon	10.1016/j.heliyon.2023.e22388	2023
Enzymology	Kinetics of alkaline protease production by Streptomyces griseoflavus PTCC1130.	Hosseini SV, Saffari Z, Farhanghi A, Atyabi SM, Norouzian D.	Iran J Microbiol		2016
	Accessing the specialized metabolome of actinobacteria from the bulk soil of Paullinia cupana Mart. on the Brazilian Amazon: a promising source of bioactive compounds against soybean phytopathogens.	Maimone NM, Apaza-Castillo GA, Quecine MC, de Lira SP.	Braz J Microbiol	10.1007/s42770-024-01286-1	2024
	In silico evaluation of potential intervention against SARS-CoV-2 RNA-dependent RNA polymerase.	Kapoor S, Singh A, Gupta V.	Phys Chem Earth (2002)	10.1016/j.pce.2022.103350	2023
	Bioaugmentation failed to enhance oil bioremediation in three soil samples from three different continents.	Radwan SS, Al-Mailem DM, Kansour MK.	Sci Rep	10.1038/s41598-019-56099-2	2019
Metabolism	Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.	Cai X, Teta R, Kohlhaas C, Crusemann M, Ueoka R, Mangoni A, Freeman MF, Piel J.	Chem Biol	10.1016/j.chembiol.2013.04.018	2013
Genetics	Genomic Investigation of Desert Streptomyces huasconensis D23 Reveals Its Environmental Adaptability and Antimicrobial Activity.	Wen Y, Zhang G, Bahadur A, Xu Y, Liu Y, Tian M, Ding W, Chen T, Zhang W, Liu G.	Microorganisms	10.3390/microorganisms10122408	2022
Phylogeny	Marine Actinobacteria: Screening for Predation Leads to the Discovery of Potential New Drugs against Multidrug-Resistant Bacteria.	Ibrahimi M, Korichi W, Hafidi M, Lemee L, Ouhdouch Y, Loqman S.	Antibiotics (Basel)	10.3390/antibiotics9020091	2020
	Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite.	Hofer I, Crusemann M, Radzom M, Geers B, Flachshaar D, Cai X, Zeeck A, Piel J.	Chem Biol	10.1016/j.chembiol.2010.12.018	2011
Metabolism	Mutation of Streptomyces griseoflavus in order to obtain high yield desferrioxamine producing fused cells.	Akbarzadeh A, Norouzian D, Farhangi A, Mehrabi MR, Shafiei M, Zare D, Saffari Z, Mortazavi M, Mardaneh M, Nemati Z.	Pak J Biol Sci	10.3923/pjbs.2007.4527.4530	2007
	Mzabimycins A and B, novel intracellular angucycline antibiotics produced by Streptomyces sp. PAL114 in synthetic medium containing L-tryptophan.	Tata S, Aouiche A, Bijani C, Bouras N, Pont F, Mathieu F, Sabaou N.	Saudi Pharm J	10.1016/j.jsps.2019.06.004	2019
	Coinoculation of soybean plants with Bradyrhizobium japonicum and Trichoderma harzianum: Coexistence of both microbes and relief of nitrate inhibition of nodulation.	Iturralde ET, Stocco MC, Faura A, Monaco CI, Cordo C, Perez-Gimenez J, Lodeiro AR.	Biotechnol Rep (Amst)	10.1016/j.btre.2020.e00461	2020
	Cross-Bioaugmentation Among Four Remote Soil Samples Contaminated With Oil Exerted Just Inconsistent Effects on Oil-Bioremediation.	Al-Mailem DM, Kansour MK, Radwan SS.	Front Microbiol	10.3389/fmicb.2019.02827	2019
Phylogeny	Genome guided investigation of antibiotics producing actinomycetales strain isolated from a Macau mangrove ecosystem.	Hu D, Chen Y, Sun C, Jin T, Fan G, Liao Q, Mok KM, Lee MS.	Sci Rep	10.1038/s41598-018-32076-z	2018
Metabolism	Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties.	Heide L, Westrich L, Anderle C, Gust B, Kammerer B, Piel J.	Chembiochem	10.1002/cbic.200800186	2008
Metabolism	Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily.	Bonitz T, Zubeil F, Grond S, Heide L.	PLoS One	10.1371/journal.pone.0085707	2013
	Bacterial Consortium for Improved Maize (Zea mays L.) Production.	Olanrewaju OS, Babalola OO.	Microorganisms	10.3390/microorganisms7110519	2019
	Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study.	Desouky SE, Abu-Elghait M, Fayed EA, Selim S, Yousuf B, Igarashi Y, Abdel-Wahab BA, Mohammed Alsuhaibani A, Sonomoto K, Nakayama J.	Metabolites	10.3390/metabo12030246	2022
	The structure of hormaomycin and one of its all-peptide aza-analogues in solution: syntheses and biological activities of new hormaomycin analogues.	Reinscheid UM, Zlatopolskiy BD, Griesinger C, Zeeck A, de Meijere A.	Chemistry	10.1002/chem.200400977	2005
	First total synthesis of hormaomycin, a naturally occurring depsipeptide with interesting biological activities.	Zlatopolskiy BD, de Meijere A.	Chemistry	10.1002/chem.200400249	2004
Pathogenicity	A novel neuronal cell protecting substance mescengricin produced by Streptomyces griseoflavus.	Shin-Ya K, Kim JS, Furihata K, Hayakawa Y, Seto H.	J Asian Nat Prod Res	10.1080/10286020008039901	2000
	Solonamides, a Group of Cyclodepsipeptides, Influence Motility in the Native Producer Photobacterium galatheae S2753.	Zhang SD, Lindqvist LL, Isbrandt T, Borre IL, Wibowo M, Nielsen MW, Ding L, Larsen TO, Gram L.	Appl Environ Microbiol	10.1128/aem.01105-22	2022
Enzymology	Characterization of Two VAO-Type Flavoprotein Oxidases from Myceliophthora thermophila.	Ferrari AR, Rozeboom HJ, Vugts ASC, Koetsier MJ, Floor R, Fraaije MW.	Molecules	10.3390/molecules23010111	2018
Phylogeny	[A new subspecies of Streptomyces griseoflavus].	Feng Q.	Wei Sheng Wu Xue Bao		1995
Metabolism	Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.	Bae M, Chung B, Oh KB, Shin J, Oh DC.	Mar Drugs	10.3390/md13085187	2015
	The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines.	Fan K, Zhang Q.	Synth Syst Biotechnol	10.1016/j.synbio.2018.11.001	2018
Metabolism	Influence of increased dissolved oxygen concentration on productivity and selectivity in cultures of a colabomycin-producing strain of Streptomyces griseoflavus.	Dick O, Onken U, Sattler I, Zeeck A.	Appl Microbiol Biotechnol	10.1007/bf00939022	1994
Metabolism	New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.	Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A.	Chembiochem	10.1002/cbic.201700428	2018
	PlasmidMaker is a versatile, automated, and high throughput end-to-end platform for plasmid construction.	Enghiad B, Xue P, Singh N, Boob AG, Shi C, Petrov VA, Liu R, Peri SS, Lane ST, Gaither ED, Zhao H.	Nat Commun	10.1038/s41467-022-30355-y	2022
	Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide.	Nouioui I, Boldt J, Zimmermann A, Makitrynskyy R, Potter G, Jando M, Doppner M, Kirstein S, Neumann-Schaal M, Gomez-Escribano JP, Nubel U, Mast Y.	Curr Res Microb Sci	10.1016/j.crmicr.2024.100290	2024
Enzymology	Metabolic products of microorganisms. 244. Colabomycins, new antibiotics of the manumycin group from Streptomyces griseoflavus. I. Isolation, characterization and biological properties.	Grote R, Zeeck A, Drautz H, Zahner H.	J Antibiot (Tokyo)	10.7164/antibiotics.41.1178	1988
Metabolism	Physiological analysis of bicozamycin high-producing Streptomyces griseoflavus used at industrial level.	Ochi K, Tsurumi Y, Shigematsu N, Iwami M, Umehara K, Okuhara M.	J Antibiot (Tokyo)	10.7164/antibiotics.41.1106	1988
Enzymology	Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site.	Xu Q, Grant J, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.	Proteins	10.1002/prot.24362	2014
	Metabolic products of microorganisms. 245. Colabomycins, new antibiotics of the manumycin group from Streptomyces griseoflavus. II. Structure of colabomycin A.	Grote R, Zeeck A, Beale JM.	J Antibiot (Tokyo)	10.7164/antibiotics.41.1186	1988
Enzymology	Characterization of cytochrome P450 monooxygenase CYP154H1 from the thermophilic soil bacterium Thermobifida fusca.	Schallmey A, den Besten G, Teune IG, Kembaren RF, Janssen DB.	Appl Microbiol Biotechnol	10.1007/s00253-010-2965-9	2011
Enzymology	Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent.	Chen JM, Shepherd MD, Horn J, Leggas M, Rohr J.	Chembiochem	10.1002/cbic.201402426	2014
Genetics	Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.	Braesel J, Crnkovic CM, Kunstman KJ, Green SJ, Maienschein-Cline M, Orjala J, Murphy BT, Eustaquio AS.	J Nat Prod	10.1021/acs.jnatprod.8b00394	2018
Metabolism	Restoration of aerial mycelium and antibiotic production in a Streptomyces griseoflavus arginine auxotroph.	Ochi K, Saito Y, Umehara K, Ueda I, Kohsaka M.	J Gen Microbiol	10.1099/00221287-130-8-2007	1984
	(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues.	de Meijere A, Kozhushkov SI, Yufit DS, Grosse C, Kaiser M, Raev VA.	Beilstein J Org Chem	10.3762/bjoc.10.302	2014
Biotechnology	Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus.	Unsaldi E, Kurt-Kizildogan A, Voigt B, Becher D, Ozcengiz G.	Synth Syst Biotechnol	10.1016/j.synbio.2016.10.003	2017
	Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated.	Liu T, Kharel MK, Fischer C, McCormick A, Rohr J.	Chembiochem	10.1002/cbic.200600031	2006
	Residual Dipolar Couplings in Structure Determination of Natural Products.	Li GW, Liu H, Qiu F, Wang XJ, Lei XX.	Nat Prod Bioprospect	10.1007/s13659-018-0174-x	2018
Metabolism	It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity.	Nordvang RT, Nyffenegger C, Holck J, Jers C, Zeuner B, Sundekilde UK, Meyer AS, Mikkelsen JD.	PLoS One	10.1371/journal.pone.0158434	2016
Metabolism	Translational Control of the SigR-Directed Oxidative Stress Response in Streptomyces via IF3-Mediated Repression of a Noncanonical GTC Start Codon.	Feeney MA, Chandra G, Findlay KC, Paget MSB, Buttner MJ.	mBio	10.1128/mbio.00815-17	2017
Metabolism	New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a gamma-Glutamyltransferase Cleave the C-C Bond?	Jiraskova P, Gazak R, Kamenik Z, Steiningerova L, Najmanova L, Kadlcik S, Novotna J, Kuzma M, Janata J.	Front Microbiol	10.3389/fmicb.2016.00276	2016
	An intramolecular inverse electron demand Diels-Alder approach to annulated alpha-carbolines.	Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK.	Beilstein J Org Chem	10.3762/bjoc.8.93	2012
Metabolism	The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis.	Hou B, Lin Y, Wu H, Guo M, Petkovic H, Tao L, Zhu X, Ye J, Zhang H.	J Bacteriol	10.1128/jb.00447-17	2018
Pathogenicity	Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.	Bihlmaier C, Welle E, Hofmann C, Welzel K, Vente A, Breitling E, Muller M, Glaser S, Bechthold A.	Antimicrob Agents Chemother	10.1128/aac.00007-06	2006
Metabolism	Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase.	Ewing TA, Nguyen QT, Allan RC, Gygli G, Romero E, Binda C, Fraaije MW, Mattevi A, van Berkel WJH.	J Biol Chem	10.1074/jbc.m117.778449	2017
Phylogeny	A novel taxonomic marker that discriminates between morphologically complex actinomycetes.	Girard G, Traag BA, Sangal V, Mascini N, Hoskisson PA, Goodfellow M, van Wezel GP.	Open Biol	10.1098/rsob.130073	2013
Enzymology	Streptovirudins, new antibiotics with antibacterial and antiviral activity. I. Culture taxonomy, fermentation and production of streptovirudin complex.	Thrum H, Eckardt K, Bradler G, Fugner R, Tonew E, Tonew M.	J Antibiot (Tokyo)	10.7164/antibiotics.28.514	1975
Enzymology	Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.	Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT.	PLoS One	10.1371/journal.pone.0167763	2016
	Evolution of the total synthesis of (-)-okilactomycin exploiting a tandem oxy-cope rearrangement/oxidation, a Petasis-Ferrier union/rearrangement, and ring-closing metathesis.	Smith AB, Bosanac T, Basu K.	J Am Chem Soc	10.1021/ja8084669	2009
Pathogenicity	Streptovirudins -- new antibiotics with antiviral activity. The antiviral spectrum and inhibition of Newcastle disease virus in cell cultures.	Tonew E, Tonew M, Eckardt K, Thrum H, Gumpert B.	Acta Virol		1975
Phylogeny	Comparative genomic and phylogenetic approaches to characterize the role of genetic recombination in mycobacterial evolution.	Smith SE, Showers-Corneli P, Dardenne CN, Harpending HH, Martin DP, Beiko RG.	PLoS One	10.1371/journal.pone.0050070	2012
Metabolism	The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size.	Tojo S, Kim JY, Tanaka Y, Inaoka T, Hiraga Y, Ochi K.	J Bacteriol	10.1128/jb.01441-13	2014
Metabolism	Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation.	Vecchione JJ, Sello JK.	J Bacteriol	10.1128/jb.00290-10	2010
Enzymology	Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis.	Kadlcik S, Kucera T, Chalupska D, Gazak R, Koberska M, Ulanova D, Kopecky J, Kutejova E, Najmanova L, Janata J.	PLoS One	10.1371/journal.pone.0084902	2013
Metabolism	SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.	Kirm B, Magdevska V, Tome M, Horvat M, Karnicar K, Petek M, Vidmar R, Baebler S, Jamnik P, Fujs S, Horvat J, Fonovic M, Turk B, Gruden K, Petkovic H, Kosec G.	Microb Cell Fact	10.1186/1475-2859-12-126	2013
	Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity.	Liu T, Kharel MK, Zhu L, Bright SA, Mattingly C, Adams VR, Rohr J.	Chembiochem	10.1002/cbic.200800348	2009
Metabolism	Biotrophy-specific downregulation of siderophore biosynthesis in Colletotrichum graminicola is required for modulation of immune responses of maize.	Albarouki E, Schafferer L, Ye F, von Wiren N, Haas H, Deising HB.	Mol Microbiol	10.1111/mmi.12561	2014
Metabolism	Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2).	Okamoto S, Lezhava A, Hosaka T, Okamoto-Hosoya Y, Ochi K.	J Bacteriol	10.1128/jb.185.2.601-609.2003	2003
	A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.	Zhang D, Iyer LM, Aravind L.	Nucleic Acids Res	10.1093/nar/gkr036	2011
Phylogeny	Polyphasic taxonomic description of Streptomyces okerensis sp. nov. and Streptomyces stoeckheimensis sp. nov. and their biotechnological potential.	Nouioui I, Derr E, Zimmermann A, Jando M, Potter G, Kirstein S, Neumann-Schaal M, Sproer C, Bunk B, Mast Y.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006716	2025
	New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.	Duangupama T, Pratuangdejkul J, Chongruchiroj S, Pittayakhajonwut P, Intaraudom C, Tadtong S, Nunthanavanit P, Samee W, He YW, Tanasupawat S, Thawai C.	Sci Rep	10.1038/s41598-023-32043-3	2023