Streptomyces cinnabarinus DSM 40467 is a mesophilic prokaryote that builds an aerial mycelium and was isolated from soil of hot climate area.
mesophilic genome sequence 16S sequence| @ref 20215 |
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| Domain Bacillati |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Kitasatosporales |
| Family Streptomycetaceae |
| Genus Streptomyces |
| Species Streptomyces cinnabarinus |
| Full scientific name Streptomyces cinnabarinus (Ryabova and Preobrazhenskaya 1957) Pridham et al. 1958 (Approved Lists 1980) |
| Synonyms (1) |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 9562 | GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) | Medium recipe at MediaDive | Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water | ||
| 19459 | ISP 2 | Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes | |||
| 19459 | ISP 3 | Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms: | |||
| 19459 | ISP 4 | Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml | |||
| 19459 | ISP 5 | Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes | |||
| 19459 | ISP 6 | Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes | |||
| 19459 | ISP 7 | Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes | |||
| 9562 | ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) | Medium recipe at MediaDive | Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water |
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | obligate aerobe | 98.3 |
| @ref | Chebi-ID | Metabolite | Utilization activity | |
|---|---|---|---|---|
| 19459 | 22599 ChEBI | arabinose | + | |
| 68368 | 29016 ChEBI | arginine | + | from API 20E |
| 19459 | 62968 ChEBI | cellulose | + | |
| 68368 | 16947 ChEBI | citrate | + | from API 20E |
| 19459 | 28757 ChEBI | fructose | + | |
| 68368 | 5291 ChEBI | gelatin | + | from API 20E |
| 19459 | 17234 ChEBI | glucose | + | |
| 68368 | 25094 ChEBI | lysine | - | from API 20E |
| 19459 | 29864 ChEBI | mannitol | + | |
| 19459 | 17268 ChEBI | myo-inositol | + | |
| 68368 | 18257 ChEBI | ornithine | - | from API 20E |
| 19459 | 16634 ChEBI | raffinose | + | |
| 19459 | 26546 ChEBI | rhamnose | + | |
| 19459 | 17992 ChEBI | sucrose | + | |
| 68368 | 27897 ChEBI | tryptophan | - | from API 20E |
| 68368 | 16199 ChEBI | urea | - | from API 20E |
| 19459 | 18222 ChEBI | xylose | - |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | + | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | + | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | + | 3.2.1.24 | from API zym |
| 68368 | arginine dihydrolase | + | 3.5.3.6 | from API 20E |
| 68382 | beta-galactosidase | + | 3.2.1.23 | from API zym |
| 68368 | beta-galactosidase | - | 3.2.1.23 | from API 20E |
| 68382 | beta-glucosidase | + | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 68382 | cystine arylamidase | + | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 68368 | gelatinase | + | from API 20E | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | + | from API zym | |
| 68368 | lysine decarboxylase | - | 4.1.1.18 | from API 20E |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 68368 | ornithine decarboxylase | - | 4.1.1.17 | from API 20E |
| 68382 | trypsin | + | 3.4.21.4 | from API zym |
| 68368 | tryptophan deaminase | - | 4.1.99.1 | from API 20E |
| 68368 | urease | - | 3.5.1.5 | from API 20E |
| 68382 | valine arylamidase | + | from API zym |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM2727031v1 assembly for Streptomyces cinnabarinus DSM 40467 | complete | 67287 | 99.43 | ||||
| 67770 | ASM71561v1 assembly for Streptomyces cinnabarinus NRRL B-12382 | scaffold | 67287 |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 20218 | Streptomyces cinnabarinus partial 16S rRNA gene, strain ISP 5467 | AJ399487 | 1448 | 67287 | ||
| 20218 | Streptomyces cinnabarinus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4463 | D44159 | 120 | 67287 | ||
| 20218 | Streptomyces cinnabarinus gene for 16S rRNA, partial sequence, strain: NBRC 13028 | AB184266 | 1476 | 67287 | ||
| 20218 | Streptomyces cinnabarinus strain NRRL B-12382 16S ribosomal RNA gene, partial sequence | DQ026640 | 1493 | 67287 |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125439 | spore_formation | BacteriaNetⓘ | yes | 90.90 | no |
| 125439 | motility | BacteriaNetⓘ | no | 90.40 | no |
| 125439 | gram_stain | BacteriaNetⓘ | positive | 99.80 | no |
| 125439 | oxygen_tolerance | BacteriaNetⓘ | obligate aerobe | 98.30 | no |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125438 | gram-positive | gram-positiveⓘ | yes | 88.04 | no |
| 125438 | anaerobic | anaerobicⓘ | no | 96.82 | no |
| 125438 | aerobic | aerobicⓘ | yes | 87.92 | no |
| 125438 | spore-forming | spore-formingⓘ | yes | 91.24 | no |
| 125438 | thermophilic | thermophileⓘ | no | 96.50 | yes |
| 125438 | flagellated | motile2+ⓘ | no | 86.50 | no |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Genetics | Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and heterologous production of the unique antibiotic roseoflavin. | Jankowitsch F, Schwarz J, Ruckert C, Gust B, Szczepanowski R, Blom J, Pelzer S, Kalinowski J, Mack M. | J Bacteriol | 10.1128/jb.01592-12 | 2012 | |
| Mechanistic Insights into Roseoflavin Synthesis by N,N-8-Demethyl-8-aminoriboflavin Dimethyltransferase (RosA): Molecular Dynamics Simulations and Residue Conservation Analysis. | Charoenwongpaiboon T, Klaewkla M, Chaiyen P, Tongsook C. | J Chem Inf Model | 10.1021/acs.jcim.3c00655 | 2023 | ||
| Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum. | Brito LF, Aas AB, Rudberg RJ, Brautaset T, Perez-Garcia F. | Microb Biotechnol | 10.1111/1751-7915.70246 | 2025 | ||
| Metabolism | Effects of Magnaporthe oryzae cell-free filtrate on the secondary metabolism of Streptomyces bikiniensis HD-087: a non-targeted metabolomics analysis. | Gang J, Tian Q, Du C. | Microb Cell Fact | 10.1186/s12934-025-02711-2 | 2025 | |
| Efficient production of bacterial antibiotics aminoriboflavin and roseoflavin in eukaryotic microorganisms, yeasts. | Dmytruk KV, Ruchala J, Fayura LR, Chrzanowski G, Dmytruk OV, Tsyrulnyk AO, Andreieva YA, Fedorovych DV, Motyka OI, Mattanovich D, Marx H, Sibirny AA. | Microb Cell Fact | 10.1186/s12934-023-02129-8 | 2023 | ||
| Metabolism | OPTIMIZATION OF THE CULTIVATION CONDITIONS AND THE BASIC MOLECULAR TOOLS FOR ROSEOFLAVIN PRODUCER STREPTOMYCES DAVAWENSIS. | Tsyrulnyk AO, Kordiaka R, Dmytruk KV, Fedorovych DV, Sybirny AA. | Mikrobiol Z | 10.15407/microbiolj78.04.002 | 2016 | |
| Dual-functionality of Nocardiopsis alba B57 in biocontrol and plant growth: a metabolomic approach to agricultural sustainability. | Abdalla Abdelshafy Mohamad O, Liu YH, Elsamahy T, Li S, Govindan R, Kuchkarova N, Hatab S, Zhang Y, Li WJ. | NPJ Biofilms Microbiomes | 10.1038/s41522-025-00796-6 | 2025 | ||
| Metabolism | Identification of the Key Enzyme of Roseoflavin Biosynthesis. | Schwarz J, Konjik V, Jankowitsch F, Sandhoff R, Mack M. | Angew Chem Int Ed Engl | 10.1002/anie.201600581 | 2016 | |
| Metabolism | Induction of antifouling diterpene production by Streptomyces cinnabarinus PK209 in co-culture with marine-derived Alteromonas sp. KNS-16. | Cho JY, Kim MS. | Biosci Biotechnol Biochem | 10.1271/bbb.120221 | 2012 | |
| Regulation of Riboflavin Biosynthesis in Microorganisms and Construction of the Advanced Overproducers of This Vitamin. | Ruchala J, Najdecka A, Wojdyla D, Liu W, Sibirny A. | Int J Mol Sci | 10.3390/ijms26136243 | 2025 | ||
| Natural riboflavin analogs. | Pedrolli DB, Jankowitsch F, Schwarz J, Langer S, Nakanishi S, Mack M. | Methods Mol Biol | 10.1007/978-1-4939-0452-5_3 | 2014 | ||
| Biotechnology | Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents. | Wissner JL, Almeida JR, Grilo IR, Oliveira JF, Brizida C, Escobedo-Hinojosa W, Pissaridou P, Vasquez MI, Cunha I, Sobral RG, Vasconcelos V, Gaudencio SP. | Front Chem | 10.3389/fchem.2024.1425953 | 2024 | |
| Metabolism | Metabolic engineering of roseoflavin-overproducing microorganisms. | Mora-Lugo R, Stegmuller J, Mack M. | Microb Cell Fact | 10.1186/s12934-019-1181-2 | 2019 | |
| Metabolism | Uptake and Metabolism of Antibiotics Roseoflavin and 8-Demethyl-8-Aminoriboflavin in Riboflavin-Auxotrophic Listeria monocytogenes. | Matern A, Pedrolli D, Grosshennig S, Johansson J, Mack M. | J Bacteriol | 10.1128/jb.00388-16 | 2016 | |
| Bioinformatics and Genomic Analyses of the Suitability of Eight Riboswitches for Antibacterial Drug Targets. | Pavlova N, Penchovsky R. | Antibiotics (Basel) | 10.3390/antibiotics11091177 | 2022 | ||
| A single change in the aptamer of the Lactiplantibacillus plantarum rib operon riboswitch severely impairs its regulatory activity and leads to a vitamin B2 - overproducing phenotype. | Ripa I, Ruiz-Maso JA, De Simone N, Russo P, Spano G, Del Solar G. | Microb Biotechnol | 10.1111/1751-7915.13919 | 2022 | ||
| Evolution of secondary metabolite genes in three closely related marine actinomycete species. | Freel KC, Nam SJ, Fenical W, Jensen PR. | Appl Environ Microbiol | 10.1128/aem.05943-11 | 2011 | ||
| Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus. | Pereira F, Almeida JR, Paulino M, Grilo IR, Macedo H, Cunha I, Sobral RG, Vasconcelos V, Gaudencio SP. | Mar Drugs | 10.3390/md18010063 | 2020 | ||
| Enzymology | Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin. | Tongsook C, Uhl MK, Jankowitsch F, Mack M, Gruber K, Macheroux P. | FEBS J | 10.1111/febs.13690 | 2016 | |
| Genetics | Genome-Based Taxonomic Classification of the Phylum Actinobacteria. | Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M. | Front Microbiol | 10.3389/fmicb.2018.02007 | 2018 | |
| Streptomyces fuscus sp. nov., a brown-black pigment producing actinomycete isolated from dry mudflat sand. | Xie J, Zhang H, Xu X, Yang K, Ou J, Yang D, Jiang Y, Jiang M, Shen N. | Int J Syst Evol Microbiol | 10.1099/ijsem.0.006047 | 2023 | ||
| Phylogeny | Isolation, characterisation and description of the roseoflavin producer Streptomyces berlinensis sp. nov. | Liunardo JJ, Messerli S, Gregotsch AK, Lang S, Schlosser K, Ruckert-Reed C, Busche T, Kalinowski J, Zischka M, Weller P, Nouioui I, Neumann-Schaal M, Risdian C, Wink J, Mack M. | Environ Microbiol Rep | 10.1111/1758-2229.13266 | 2024 | |
| Metabolism | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | Kim SB, Goodfellow M. | Int J Syst Evol Microbiol | 10.1099/00207713-52-6-2011 | 2002 | |
| Phylogeny | Streptomyces fractus sp. nov., a novel streptomycete isolated from the gut of a South African termite. | Rohland J, Meyers PR | Antonie Van Leeuwenhoek | 10.1007/s10482-015-0404-8 | 2015 | |
| Phylogeny | Taxonomic analyses of members of the Streptomyces cinnabarinus cluster, description of Streptomyces cinnabarigriseus sp. nov. and Streptomyces davaonensis sp. nov. | Landwehr W, Kampfer P, Glaeser SP, Ruckert C, Kalinowski J, Blom J, Goesmann A, Mack M, Schumann P, Atasayar E, Hahnke RL, Rohde M, Martin K, Stadler M, Wink J | Int J Syst Evol Microbiol | 10.1099/ijsem.0.002519 | 2017 |
| #9562 | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40467 |
| #19459 | Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig . |
| #20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 ) |
| #20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 ) |
| #66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) . |
| #67770 | Japan Collection of Microorganism (JCM) ; Curators of the JCM; |
| #68368 | Automatically annotated from API 20E . |
| #68382 | Automatically annotated from API zym . |
| #125438 | Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 ) |
| #125439 | Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 . |
| #126262 | A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 ) |
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