Streptomyces chromofuscus (DSM 40273, ATCC 23896, CBS 682.68)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	9424
  multimedia content:	DSM_40273.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40273.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9424	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
19429	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19429	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19429	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19429	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
9424	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Halophily

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
19429	22599 ChEBI	arabinose	-
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
19429	62968 ChEBI	cellulose	-
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
19429	28757 ChEBI	fructose	+
68368	5291 ChEBI	gelatin	-	hydrolysis	from API 20E
19429	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	-	degradation	from API 20E
19429	29864 ChEBI	mannitol	+
19429	17268 ChEBI	myo-inositol	+
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
19429	16634 ChEBI	raffinose	+
19429	26546 ChEBI	rhamnose	+
19429	17992 ChEBI	sucrose	-
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	-	hydrolysis	from API 20E
19429	18222 ChEBI	xylose	+

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68368	gelatinase	-		from API 20E
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	-	3.5.1.5	from API 20E

API 20E

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1516087v1 assembly for Streptomyces chromofuscus DSM 40273	complete	GCA_015160875	42881.4		42881	99.47
66792	ASM1464943v1 assembly for Streptomyces chromofuscus JCM 4354	scaffold	GCA_014649435	42881.3	8113515779	42881	41.43

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces chromofuscus gene for 16S rRNA, partial sequence	AB122731	564		42881
20218	Streptomyces chromofuscus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4354	D44072	120		42881
20218	Streptomyces chromofuscus gene for 16S rRNA, partial sequence, strain: NBRC 12851	AB184194	1469		42881
20218	Streptomyces chromofuscus strain NRRL B-12175 16S ribosomal RNA gene, partial sequence	AY999800	1457		42881
124043	Streptomyces chromofuscus strain JCM 4354 16S ribosomal RNA gene, partial sequence.	MT760518	1325		42881

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	First draft genome sequence data of TA4-1, the type strain of Gram-positive bacterium Streptomyces chiangmaiensis.	Yasawong M, Rosyidah A, Songngamsuk T, Phatcharaharikarn M, Ganta P, Chanthasena P, Chudapongse N, Santapan N, Srisakvarangkool W, Kerdtoob S, Nantapong N.	Data Brief	10.1016/j.dib.2024.110611	2024
	Endophytic actinobacteria of a halophytic desert plant Pteropyrum olivieri: promising growth enhancers of sunflower.	Zahra T, Hamedi J, Mahdigholi K.	3 Biotech	10.1007/s13205-020-02507-8	2020
	New natural products from Aspergillus candidus NRRL 5214 and their glycosylation by Streptomyces chromofuscus ATCC 49982.	Ren J, Jackson K, Barton CD, Sher H, Huang Y, Zhan J.	J Biosci Bioeng	10.1016/j.jbiosc.2025.03.002	2025
	Microbial glycosylation of antitubercular agent chlorflavonin.	Ren J, Zhan J.	J Biosci Bioeng	10.1016/j.jbiosc.2023.09.005	2023
	Enzymatic Modification of Lecithin for Improved Antioxidant Activity in Combination with Tocopherol in Emulsions and Bulk Oil.	Culler MD, Bayram I, Decker EA.	J Agric Food Chem	10.1021/acs.jafc.2c05182	2022
	Identification of a novel glucuronyltransferase from Streptomyces chromofuscus ATCC 49982 for natural product glucuronidation.	Ren J, Barton CD, Sorenson KE, Zhan J.	Appl Microbiol Biotechnol	10.1007/s00253-022-11789-2	2022
	Engineering regiospecific methylation of the pladienolides.	Smith ER, Al-Smadi DH, Dai Y, Khin M, Burdette JE, Duggan BM, La Clair JJ, Eustaquio AS, Burkart MD.	RSC Chem Biol	10.1039/d5cb00068h	2025
	High-level soluble expression of phospholipase D from Streptomyces chromofuscus in Escherichia coli by combinatorial optimization	Wu R, Cao J, Liu F, Yang M, Su E.	Electron J Biotechnol		2021
Metabolism	Establishing Conserved Biosynthetic Gene Clusters of the Phylum Myxococcota	Pokharel S, Shehata N, Ahearne A, Knehans T, Bailey C, Boudreau P, Stevens D.	bioRxiv		2025
	Protein scaffold optimizes arrangement of constituent enzymes in indigoidine synthetic pathway to improve the pigment production.	Wang L, Sun Y, Lv D, Liu B, Guan Y, Yu D.	Appl Microbiol Biotechnol	10.1007/s00253-020-10990-5	2020
Metabolism	C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A.	Hong H, Samborskyy M, Zhou Y, Leadlay PF.	Cell Chem Biol	10.1016/j.chembiol.2018.12.004	2019
	Production of a High-Phosphatidylserine Lecithin That Synergistically Inhibits Lipid Oxidation with alpha-Tocopherol in Oil-in-Water Emulsions.	Arora H, Culler MD, Decker EA.	Foods	10.3390/foods11071014	2022
Enzymology	Immobilization of Phospholipase D on Fe3O4@SiO2-Graphene Oxide Nanocomposites: A Strategy to Improve Catalytic Stability and Reusability in the Efficient Production of Phosphatidylserine.	Shang H, Wang J, Guo B, Zhu H, Li H.	Molecules	10.3390/molecules30040912	2025
	Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.	Ishii K, Hermans SJ, Georgopoulou ME, Nero TL, Hancock NC, Crespi GAN, Gorman MA, Gooi JH, Parker MW.	FEBS J	10.1111/febs.17277	2024
Biotechnology	Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants.	Diez BH, Torres CAV, Gaudencio SP.	Mar Drugs	10.3390/md23010039	2025
Metabolism	Enhancement of herboxidiene production in Streptomyces chromofuscus ATCC 49982.	Jha AK, Lamichhane J, Sohng JK.	J Microbiol Biotechnol	10.4014/jmb.1308.08063	2014
Metabolism	High-yield phosphatidylserine production via yeast surface display of phospholipase D from Streptomyces chromofuscus on Pichia pastoris.	Liu Y, Zhang T, Qiao J, Liu X, Bo J, Wang J, Lu F.	J Agric Food Chem	10.1021/jf405836x	2014
	The prevention of benign prostatic hyperplasia (bph).	Roper WG.	Med Hypotheses	10.1016/j.mehy.2016.12.013	2017
	Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays.	Djakpa H, Kulkarni A, Barrows-Murphy S, Miller G, Zhou W, Cho H, Torok B, Stieglitz K.	Chem Biol Drug Des	10.1111/cbdd.12705	2016
Metabolism	A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of alpha,beta-Epoxyketone Proteasome Inhibitors.	Zabala D, Cartwright JW, Roberts DM, Law BJ, Song L, Samborskyy M, Leadlay PF, Micklefield J, Challis GL.	J Am Chem Soc	10.1021/jacs.6b01619	2016
	Analysis of Molecular Species Profiles of Ceramide-1-phosphate and Sphingomyelin Using MALDI-TOF Mass Spectrometry.	Yamashita R, Tabata Y, Iga E, Nakao M, Sano S, Kogure K, Tokumura A, Tanaka T.	Lipids	10.1007/s11745-015-4082-0	2016
Metabolism	Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide.	Pokhrel AR, Dhakal D, Jha AK, Sohng JK.	Appl Microbiol Biotechnol	10.1007/s00253-015-6860-2	2015
	Development of a Direct and Continuous Phospholipase D Assay Based on the Chelation-Enhanced Fluorescence Property of 8-Hydroxyquinoline.	Rahier R, Noiriel A, Abousalham A.	Anal Chem	10.1021/acs.analchem.5b02332	2016
Enzymology	Syncephalastrum racemosum amine oxidase with high catalytic efficiency toward ethanolamine and its application in ethanolamine determination.	Hirano Y, Chonan K, Murayama K, Sakasegawa SI, Matsumoto H, Sugimori D.	Appl Microbiol Biotechnol	10.1007/s00253-015-7198-5	2016
	Assay of Phospholipase D Activity by an Amperometric Choline Oxidase Biosensor.	Ciriello R, Guerrieri A.	Sensors (Basel)	10.3390/s20051304	2020
Metabolism	Efficient production of indigoidine in Escherichia coli.	Xu F, Gage D, Zhan J.	J Ind Microbiol Biotechnol	10.1007/s10295-015-1642-5	2015
	Application of Hosomi-Sakurai allylation reaction in total synthesis of biologically active natural products.	Akwensi J, Kumah RT, Osei-Safo D, Amewu RK.	Front Chem	10.3389/fchem.2025.1527387	2025
Metabolism	Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase.	Jha AK, Dhakal D, Van PT, Pokhrel AR, Yamaguchi T, Jung HJ, Yoon YJ, Sohng JK.	Appl Microbiol Biotechnol	10.1007/s00253-015-6431-6	2015
Metabolism	An indigoidine biosynthetic gene cluster from Streptomyces chromofuscus ATCC 49982 contains an unusual IndB homologue.	Yu D, Xu F, Valiente J, Wang S, Zhan J.	J Ind Microbiol Biotechnol	10.1007/s10295-012-1207-9	2013
	[An expedient synthesis of fluorescent labeled ceramide-1-phosphate analogues].	Boldyrev IA, Braun RE, Molotkovskii IuG.	Bioorg Khim	10.1134/s106816201305004x	2013
	GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts.	Granatosky EA, DiPrimio N, Pickering JRE, Stevens DC, Perlstein EO, Taylor RE.	J Nat Prod	10.1021/acs.jnatprod.8b00314	2018
Metabolism	Switching antibiotics production on and off in actinomycetes by an IclR family transcriptional regulator from Streptomyces peucetius ATCC 27952.	Chaudhary AK, Singh B, Maharjan S, Jha AK, Kim BG, Sohng JK.	J Microbiol Biotechnol	10.4014/jmb.1403.03026	2014
Metabolism	Characterization of a methyltransferase involved in herboxidiene biosynthesis.	Yu D, Xu F, Zhang S, Shao L, Wang S, Zhan J.	Bioorg Med Chem Lett	10.1016/j.bmcl.2013.08.023	2013
Metabolism	Direct determination of phospholipase D activity by infrared spectroscopy.	Do le D, Buchet R, Pikula S, Abousalham A, Mebarek S.	Anal Biochem	10.1016/j.ab.2012.07.017	2012
	Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood.	Guo J, Wang H, Hrinczenko B, Salomon RG.	Chem Res Toxicol	10.1021/acs.chemrestox.6b00152	2016
Enzymology	Influencing emulsifying properties of egg yolk by enzymatic modification by phospholipase D from Streptomyces chromofuscus Part 1: technological properties of incubated egg yolk.	Buxmann W, Bindrich U, Heinz V, Knorr D, Franke K.	Colloids Surf B Biointerfaces	10.1016/j.colsurfb.2009.10.032	2010
	V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid.	Wang Q, Wolf A, Ozkan S, Richert L, Mely Y, Chasserot-Golaz S, Ory S, Gasman S, Vitale N.	Front Mol Biosci	10.3389/fmolb.2023.1163545	2023
	Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D.	Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS.	J Biol Chem	10.1074/jbc.ra120.013362	2020
Metabolism	Continuous monitoring of phospholipid vesicle hydrolysis by phospholipase D (PLD) reveals differences in hydrolysis by PLDs from 2 Streptomyces species.	Hirano S, Sekine K, Handa T, Nakano M.	Colloids Surf B Biointerfaces	10.1016/j.colsurfb.2011.11.059	2012
	Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis.	Meyer J, Meyer LE, Kara S.	Eng Life Sci	10.1002/elsc.202100087	2022
Genetics	Genotype-Specific Activation of Autophagy during Heat Wave in Wheat.	Hickey K, Sahin Y, Turner G, Nazarov T, Jitkov V, Pumphrey M, Smertenko A.	Cells	10.3390/cells13141226	2024
	Potential of Aspergillus oryzae as a biosynthetic platform for indigoidine, a non-ribosomal peptide pigment with antioxidant activity.	Panchanawaporn S, Chutrakul C, Jeennor S, Anantayanon J, Rattanaphan N, Laoteng K.	PLoS One	10.1371/journal.pone.0270359	2022
Enzymology	Purification and characterisation of a protease inhibitor from Streptomyces chromofuscus 34-1 with an antiviral activity.	Angelova L, Dalgalarrondo M, Minkov I, Danova S, Kirilov N, Serkedjieva J, Chobert JM, Haertle T, Ivanova I.	Biochim Biophys Acta	10.1016/j.bbagen.2006.03.002	2006
Enzymology	Simple and rapid biochemical method to synthesize labeled or unlabeled phosphatidylinositol species.	Hanninen S, Batchu KC, Hokynar K, Somerharju P.	J Lipid Res	10.1194/jlr.d075960	2017
	Identification of new glutamate decarboxylases from Streptomyces for efficient production of gamma-aminobutyric acid in engineered Escherichia coli.	Yuan H, Wang H, Fidan O, Qin Y, Xiao G, Zhan J.	J Biol Eng	10.1186/s13036-019-0154-7	2019
	Preparation of Phosphatidylated Terpenes via Phospholipase D-Mediated Transphosphatidylation	Yamamoto Y, Hosokawa M, Kurihara H, Miyashita K.	J Am Oil Chem Soc	10.1007/s11746-008-1206-1	2008
	Cryptic Phosphorylation-Mediated Divergent Biosynthesis of High-Carbon Sugar Nucleoside Antifungals.	Draelos MM, Thanapipatsiri A, Du Y, Yokoyama K.	ACS Chem Biol	10.1021/acschembio.1c00971	2022
	Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression.	Sellin M, Mack R, Rhodes MC, Zhang L, Berg S, Joshi K, Liu S, Wei W, S J PB, Larsen P, Taylor RE, Zhang J.	Br J Cancer	10.1038/s41416-022-01796-5	2022
Enzymology	Characterisitics and gene cloning of phospholipase D of the psychrophile, Shewanella sp.	Tsuruta H, Hayashi R, Ohkawa H, Ohkatsu N, Morimoto M, Nishimoto K, Santou S, Aizono Y.	Biosci Biotechnol Biochem	10.1271/bbb.70325	2007
Metabolism	Evaluation of the Impact of Esterases and Lipases from the Circulatory System against Substrates of Different Lipophilicity.	Lam L, Ilies MA.	Int J Mol Sci	10.3390/ijms23031262	2022
Metabolism	Blistering of supported lipid membranes induced by Phospholipase D, as observed by real-time atomic force microscopy.	El Kirat K, Dupres V, Dufrene YF.	Biochim Biophys Acta	10.1016/j.bbamem.2007.09.029	2008
Metabolism	Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.	Shao L, Zi J, Zeng J, Zhan J.	Appl Environ Microbiol	10.1128/aem.06904-11	2012
	Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin.	Billon-Denis E, Tanfin Z, Robin P.	J Lipid Res	10.1194/jlr.m700171-jlr200	2008
Metabolism	Streptomyces chromofuscus phospholipase D interaction with lipidic activators at the air-water interface.	El Kirat K, Chauvet JP, Roux B, Besson F.	Biochim Biophys Acta	10.1016/j.bbamem.2003.12.010	2004
Enzymology	Expression and characterization of a heterodimer of Streptomyces chromofuscus phospholipase D.	Yang H, Roberts MF.	Biochim Biophys Acta	10.1016/j.bbapap.2004.09.014	2004
	Conversion of Phosphatidylcholine to Phosphatidylglycerol with Phospholipase D and Glycerol	Piazza GJ, Marmer WN.	J Am Oil Chem Soc	10.1007/s11746-007-1081-1	2007
	Splicing modulators: on the way from nature to clinic.	Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M.	J Antibiot (Tokyo)	10.1038/s41429-021-00450-1	2021
Metabolism	Measurement of dietary choline-phospholipid content by a novel phospholipase D-triiodide method.	Ueda A, Hanada A, Ishinaga M.	J Nutr Sci Vitaminol (Tokyo)	10.3177/jnsv.52.79	2006
Metabolism	Transphosphatidylation activity of Streptomyces chromofuscus phospholipase D in biomimetic membranes.	El Kirat K, Prigent AF, Chauvet JP, Roux B, Besson F.	Eur J Biochem	10.1046/j.1432-1033.2003.03841.x	2003
Enzymology	Inhibition of Streptomyces chromofuscus phospholipase D activity by dichloro-(2,2':6',2''-terpyridine)-platinum (II) dihydrate.	Kubota-Akizawa M, Negishi T, Mori K, Hatanaka T.	J Enzyme Inhib Med Chem	10.1080/1475636021000033252	2002
	Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.	Liebov BK, Arroyo AD, Rubtsova NI, Osharovich SA, Delikatny EJ, Popov AV.	ACS Omega	10.1021/acsomega.8b00635	2018
Metabolism	Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions.	Apel AK, Sola-Landa A, Rodriguez-Garcia A, Martin JF.	Microbiology (Reading)	10.1099/mic.0.2007/007070-0	2007
Enzymology	Mutagenesis of putative catalytic and regulatory residues of Streptomyces chromofuscus phospholipase D differentially modifies phosphatase and phosphodiesterase activities.	Zambonelli C, Casali M, Roberts MF.	J Biol Chem	10.1074/jbc.m310252200	2003
	Coupling Lipid Nanoparticle Structure and Automated Single-Particle Composition Analysis to Design Phospholipase-Responsive Nanocarriers.	Barriga HMG, Pence IJ, Holme MN, Doutch JJ, Penders J, Nele V, Thomas MR, Carroni M, Stevens MM, Stevens MM.	Adv Mater	10.1002/adma.202200839	2022
	Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.	Qu XY, Ren JW, Peng AH, Lin SQ, Lu DD, Du QQ, Liu L, Li X, Li EW, Xie WD.	Mar Drugs	10.3390/md17050277	2019
Metabolism	Streptomyces sp. VN1, a producer of diverse metabolites including non-natural furan-type anticancer compound.	Nguyen HT, Pokhrel AR, Nguyen CT, Pham VTT, Dhakal D, Lim HN, Jung HJ, Kim TS, Yamaguchi T, Sohng JK.	Sci Rep	10.1038/s41598-020-58623-1	2020
Metabolism	Binding of proteolytically processed phospholipase D from Streptomyces chromofuscus to phosphatidylcholine membranes facilitates vesicle aggregation and fusion.	Stieglitz KA, Seaton BA, Roberts MF.	Biochemistry	10.1021/bi011338o	2001
Metabolism	Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells.	Peng A, Qu X, Liu F, Li X, Li E, Xie W.	Mar Drugs	10.3390/md16120470	2018
Enzymology	Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay.	Martin SF, DeBlanc RL, Hergenrother PJ.	Anal Biochem	10.1006/abio.1999.4420	2000
Pathogenicity	Antimicrobial agent triclosan suppresses mast cell signaling via phospholipase D inhibition.	Shim JK, Caron MA, Weatherly LM, Gerchman LB, Sangroula S, Hattab S, Baez AY, Briana TJ, Gosse JA.	J Appl Toxicol	10.1002/jat.3884	2019
Metabolism	Anti-apoptotic mechanism and reduced expression of phospholipase D in spontaneous and Fas-stimulated apoptosis of human neutrophils.	Lee SY, Oh JY, Lee MJ, Jang MJ, Park HY, Kim JW, Min DS, Park YM, Chang YC, Bae YS, Kwak JY.	Eur J Immunol	10.1002/eji.200425117	2004
	Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery.	Shamikh YI, El Shamy AA, Gaber Y, Abdelmohsen UR, Madkour HA, Madkour HA, Horn H, Hassan HM, Elmaidomy AH, Alkhalifah DHM, Hozzein WN.	Microorganisms	10.3390/microorganisms8050783	2020
Metabolism	The role of interfacial binding in the activation of Streptomyces chromofuscus phospholipase D by phosphatidic acid.	Stieglitz K, Seaton B, Roberts MF.	J Biol Chem	10.1074/jbc.274.50.35367	1999
	Preassembled Fluorescent Multivalent Probes for the Imaging of Anionic Membranes.	Roland FM, Peck EM, Rice DR, Smith BD.	Bioconjug Chem	10.1021/acs.bioconjchem.7b00012	2017
Enzymology	Chromogenic assay for phospholipase D from Streptomyces chromofuscus: application to the evaluation of substrate analogs.	Hergenrother PJ, Haas MK, Martin SF.	Lipids	10.1007/s11745-997-0101-5	1997
Enzymology	A 20-kDa domain is required for phosphatidic acid-induced allosteric activation of phospholipase D from Streptomyces chromofuscus.	Geng D, Baker DP, Foley SF, Zhou C, Stieglitz K, Roberts MF.	Biochim Biophys Acta	10.1016/s0167-4838(99)00005-9	1999
Metabolism	Using O-(n-alkyl)-N-(N,N'-dimethylethyl)phosphoramidates to investigate the role of Ca2+ and interfacial binding in a bacterial phospholipase D.	Oh MK, Yang H, Roberts MF.	Biochim Biophys Acta	10.1016/s1570-9639(03)00166-3	2003
Metabolism	An iron-dependent bacterial phospholipase D reminiscent of purple acid phosphatases.	Zambonelli C, Roberts MF.	J Biol Chem	10.1074/jbc.m210363200	2003
	Inhibition of phospholipase D alpha by N-acylethanolamines.	Austin-Brown SL, Chapman KD.	Plant Physiol	10.1104/pp.001974	2002
Metabolism	Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin.	Shimada Y, Li YT, Li SC.	J Lipid Res	10.1194/jlr.m200234-jlr200	2003
	Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.	Gross R, Ressin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preusser C, Seehafer K, Pohlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Munch J, Muller JA.	Nat Microbiol	10.1038/s41564-024-01637-6	2024
	Assessment and optimization of xylanase production using co-cultures of Bacillus subtilis and Kluyveromyces marxianus.	Yardimci GO, Cekmecelioglu D.	3 Biotech	10.1007/s13205-018-1315-y	2018
Metabolism	Role of calcium and membrane organization on phospholipase D localization and activity. Competition between a soluble and insoluble substrate.	El Kirat K, Besson F, Prigent AF, Chauvet JP, Roux B.	J Biol Chem	10.1074/jbc.m106449200	2002
Metabolism	A spectrophotometric assay for the transphosphatidylation activity of phospholipase D enzyme.	Hagishita T, Nishikawa M, Hatanaka T.	Anal Biochem	10.1006/abio.1999.4353	1999
Metabolism	Rhamnose Links Moonlighting Proteins to Membrane Phospholipid in Mycoplasmas.	Daubenspeck JM, Liu R, Dybvig K.	PLoS One	10.1371/journal.pone.0162505	2016
	Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria.	Morita SY, Terada T.	Sci Rep	10.1038/srep11737	2015
Enzymology	Purification and N-terminal sequence analysis of Streptomyces chromofuscus phospholipase D.	Dinh TT, McClure GD, Kennerly DA.	Int Arch Allergy Immunol	10.1159/000236934	1995
Metabolism	Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.	Banno Y, Takuwa Y, Akao Y, Okamoto H, Osawa Y, Naganawa T, Nakashima S, Suh PG, Nozawa Y.	J Biol Chem	10.1074/jbc.m105673200	2001
Enzymology	Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site.	Rodriguez F, Lillington J, Johnson S, Timmel CR, Lea SM, Berks BC.	J Biol Chem	10.1074/jbc.m114.604892	2014
Metabolism	The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.	Freeman EJ.	Arch Biochem Biophys	10.1006/abbi.1999.1608	2000
Metabolism	Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module.	Fortinez CM, Bloudoff K, Harrigan C, Sharon I, Strauss M, Schmeing TM.	Nat Commun	10.1038/s41467-022-28221-y	2022
Enzymology	Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties.	Miller-Wideman M, Makkar N, Tran M, Isaac B, Biest N, Stonard R.	J Antibiot (Tokyo)	10.7164/antibiotics.45.914	1992
Enzymology	Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells: role of phospholipase D in CD16-triggered degranulation.	Milella M, Gismondi A, Roncaioli P, Palmieri G, Morrone S, Piccoli M, Frati L, Cifone MG, Santoni A.	J Immunol		1999
Metabolism	Tyrosine phosphorylation of 100-115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes.	Ohguchi K, Kasai T, Nozawa Y.	Biochim Biophys Acta	10.1016/s0005-2760(97)00043-x	1997
	Hydrogen peroxide mediates spermidine-induced autophagy to alleviate salt stress in cucumber.	Zhang Y, Wang Y, Wen W, Shi Z, Gu Q, Ahammed GJ, Cao K, Shah Jahan M, Shu S, Wang J, Sun J, Guo S.	Autophagy	10.1080/15548627.2020.1847797	2021
Metabolism	Phospholipase D activity facilitates Ca2+-induced aggregation and fusion of complex liposomes.	Blackwood RA, Smolen JE, Transue A, Hessler RJ, Harsh DM, Brower RC, French S.	Am J Physiol	10.1152/ajpcell.1997.272.4.c1279	1997
Metabolism	Conversion of lysophospholipids to cyclic lysophosphatidic acid by phospholipase D.	Friedman P, Haimovitz R, Markman O, Roberts MF, Shinitzky M.	J Biol Chem	10.1074/jbc.271.2.953	1996
Metabolism	Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways.	van Dijk MC, Postma F, Hilkmann H, Jalink K, van Blitterswijk WJ, Moolenaar WH.	Curr Biol	10.1016/s0960-9822(98)70157-5	1998
	Biomolecular condensates create phospholipid-enriched microenvironments.	Dumelie JG, Chen Q, Miller D, Attarwala N, Gross SS, Jaffrey SR.	Nat Chem Biol	10.1038/s41589-023-01474-4	2024
	Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement.	Holme MN, Rashid MH, Thomas MR, Barriga HMG, Herpoldt KL, Heenan RK, Dreiss CA, Banuelos JL, Xie HN, Yarovsky I, Stevens MM.	ACS Cent Sci	10.1021/acscentsci.8b00286	2018
Metabolism	A Molecular Target for an Alcohol Chain-Length Cutoff.	Chung HW, Petersen EN, Cabanos C, Murphy KR, Pavel MA, Hansen AS, Ja WW, Hansen SB.	J Mol Biol	10.1016/j.jmb.2018.11.028	2019
Metabolism	Regulation of phospholipase D activity by neutral lipids in egg-yolk phosphatidylcholine small unilamellar vesicles and by calcium ion in aqueous medium.	Yamamoto I, Konto A, Handa T, Miyajima K.	Biochim Biophys Acta	10.1016/0005-2736(94)00220-j	1995
Metabolism	Isoketals form cytotoxic phosphatidylethanolamine adducts in cells.	Sullivan CB, Matafonova E, Roberts LJ, Amarnath V, Davies SS.	J Lipid Res	10.1194/jlr.m001040	2010
Metabolism	Conductimetric assays for the hydrolase and transferase activities of phospholipase D enzymes.	Mezna M, Lawrence AJ.	Anal Biochem	10.1006/abio.1994.1194	1994
Metabolism	Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture.	Hansen HS, Lauritzen L, Strand AM, Moesgaard B, Frandsen A.	Biochim Biophys Acta	10.1016/0005-2760(95)00134-x	1995
	Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).	Wang H, Guo J, West XZ, Bid HK, Lu L, Hong L, Jang GF, Zhang L, Crabb JW, Clinical Genomic and Proteomic AMD Study Group, Linetsky M, Salomon RG.	Chem Res Toxicol	10.1021/tx500216a	2014
Enzymology	Reduced kidney levels of lysophosphatidic acids in rats after chronic administration of aristolochic acid: Its possible protective role in renal fibrosis.	Tsutsumi T, Yamakawa S, Ishihara A, Yamamoto A, Tanaka T, Tokumura A.	Toxicol Rep	10.1016/j.toxrep.2015.02.012	2015
	In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives.	Kato S, Kawasaki T, Urata T, Mochizuki J.	J Antibiot (Tokyo)	10.7164/antibiotics.46.1859	1993
	Antioxidant activities of natural and synthetic carbazoles.	Iwatsuki M, Niki E, Kato S.	Biofactors		1993
Enzymology	Stimulation of rat liver microsomal cGMP-inhibited cAMP phosphodiesterase (PDE III) by phospholipase C and D.	Carpenedo F, Floreani M.	Biochem Biophys Res Commun	10.1006/bbrc.1993.1092	1993
Metabolism	Chloramphenicol oxamylethanolamine as an end product of chloramphenicol metabolism in rat and humans: evidence for the formation of a phospholipid adduct.	Cravedi JP, Perdu-Durand E, Baradat M, Alary J, Debrauwer L, Bories G.	Chem Res Toxicol	10.1021/tx00047a003	1995
Metabolism	PLD1 participates in BDNF-induced signalling in cortical neurons.	Ammar MR, Thahouly T, Hanauer A, Stegner D, Nieswandt B, Vitale N.	Sci Rep	10.1038/srep14778	2015
Metabolism	Arachidonic acid liberation induced by phosphatidic acid endogenously generated from membrane phospholipids in rabbit platelets.	Hashizume T, Taniguchi M, Sato T, Fujii T.	Biochim Biophys Acta	10.1016/0167-4889(94)90011-6	1994
Metabolism	Enzymatic fluorometric assays for quantifying all major phospholipid classes in cells and intracellular organelles.	Tsuji T, Morita SY, Ikeda Y, Terada T.	Sci Rep	10.1038/s41598-019-45185-0	2019
Pathogenicity	Fusion of phospholipid vesicles induced by phospholipase D in the presence of calcium ion.	Park JB, Lee TH, Kim H.	Biochem Int		1992
Metabolism	Structure elucidation of A58365A and A58365B, angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus.	Hunt AH, Mynderse JS, Samlaska SK, Fukuda DS, Maciak GM, Kirst HA, Occolowitz JL, Swartzendruber JK, Jones ND.	J Antibiot (Tokyo)	10.7164/antibiotics.41.771	1988
Metabolism	Phosphatidylcholine hydrolysis and DNA synthesis in cultured retinal capillary pericytes.	Li W, Liu X, Yanoff M.	Microvasc Res	10.1006/mvre.1995.1030	1995
Metabolism	Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo.	Levy BD, Hickey L, Morris AJ, Larvie M, Keledjian R, Petasis NA, Bannenberg G, Serhan CN.	Br J Pharmacol	10.1038/sj.bjp.0706338	2005
	Effects of 1,2-diacylglycerol and cholesterol on the hydrolysis activity of phospholipase D in egg-yolk phosphatidylcholine bilayers.	Yamamoto I, Mazumi T, Handa T, Miyajima K.	Biochim Biophys Acta	10.1016/0005-2736(93)90302-g	1993
Enzymology	Synthesis and biological evaluation of radioiodinated phospholipid ether stereoisomers.	Rampy MA, Pinchuk AN, Weichert JP, Skinner RW, Fisher SJ, Wahl RL, Gross MD, Counsell RE.	J Med Chem	10.1021/jm00016a019	1995
	Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass.	Sun G, Wase N, Shu S, Jenkins J, Zhou B, Torres-Rodriguez JV, Chen C, Sandor L, Plott C, Yoshinga Y, Daum C, Qi P, Barry K, Lipzen A, Berry L, Pedersen C, Gottilla T, Foltz A, Yu H, O'Malley R, Zhang C, Devos KM, Sigmon B, Yu B, Obata T, Schmutz J, Schnable JC.	Nat Commun	10.1038/s41467-022-35507-8	2022
Metabolism	Phospholipase D-catalyzed hydrolysis of phosphatidylcholine occurs with P-O bond cleavage.	Holbrook PG, Pannell LK, Daly JW.	Biochim Biophys Acta	10.1016/0005-2760(91)90214-3	1991
Metabolism	Isolation of A58365A and A58365B, angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus.	Mynderse JS, Samlaska SK, Fukuda DS, Du Bus RH, Baker PJ.	J Antibiot (Tokyo)	10.7164/antibiotics.38.1003	1985
Metabolism	Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells.	Kondo T, Inui H, Konishi F, Inagami T.	J Biol Chem	10.1016/s0021-9258(18)35882-4	1992
Metabolism	Angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus. Discovery, taxonomy and fermentation.	Nakatsukasa WM, Wilgus RM, Thomas DN, Mertz FP, Boeck LD.	J Antibiot (Tokyo)	10.7164/antibiotics.38.997	1985
Metabolism	The phosphatase inhibitor 2,3-diphosphoglycerate interferes with phospholipase D activation in rabbit peritoneal neutrophils.	Kanaho Y, Nakai Y, Katoh M, Nozawa Y.	J Biol Chem	10.1016/s0021-9258(18)31415-7	1993
	Semi-synthetic approach for the preparation of homogeneous plasmenylethanolamine utilizing phospholipase D from Streptomyces chromofuscus.	Wolf RA, Gross RW.	J Lipid Res	10.1016/s0022-2275(20)34351-0	1985
Metabolism	Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine.	Aridor-Piterman O, Lavie Y, Liscovitch M.	Eur J Biochem	10.1111/j.1432-1033.1992.tb16668.x	1992
Metabolism	Use of [1-14C]oleate labelled autoclaved Escherichia coli as a membranous substrate for measurement of in vitro phospholipase D activity.	Ghosh SS, Franson RC.	Biochem Cell Biol	10.1139/o92-006	1992
Metabolism	Studies on peroxidation processes of model membranes and synaptosomes: role of phosphatidic acid.	Viani P, Cervato G, Fiorilli A, Rigamonti E, Cestaro B.	Chem Phys Lipids	10.1016/0009-3084(90)90006-d	1990
Metabolism	Biologically active ether lipids. Biotransformation of rac-1(3)-O-alkylglycerols in cell suspension cultures of rape and semisynthesis of 1-O-alkyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamines, potent antitumor agents.	Apte SS, Weber N, Mangold HK.	FEBS Lett	10.1016/0014-5793(90)80894-o	1990
Metabolism	Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines.	Diep TA, Madsen AN, Krogh-Hansen S, Al-Shahwani M, Al-Sabagh L, Holst B, Hansen HS.	PLoS One	10.1371/journal.pone.0100365	2014
Metabolism	A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.	Van Veldhoven PP, Foglesong RJ, Bell RM.	J Lipid Res	10.1016/s0022-2275(20)38352-8	1989
Metabolism	Novel bisretinoids of human retina are lyso alkyl ether glycerophosphoethanolamine-bearing A2PE species.	Kim HJ, Sparrow JR.	J Lipid Res	10.1194/jlr.m084459	2018
	Phospholipase D activity is regulated by product segregation and the structure formation of phosphatidic acid within model membranes.	Wagner K, Brezesinski G.	Biophys J	10.1529/biophysj.107.108787	2007
Metabolism	N-acylphosphatidylethanolamine synthesis in plants: occurrence, molecular composition, and phospholipid origin.	Chapman KD, Moore TS.	Arch Biochem Biophys	10.1006/abbi.1993.1110	1993
Metabolism	A sensitive and specific radioenzymatic assay for the simultaneous determination of choline and phosphatidylcholine.	Muma NA, Rowell PP.	J Neurosci Methods	10.1016/0165-0270(85)90008-1	1985
	Cycad Coralloid Roots Contain Bacterial Communities Including Cyanobacteria and Caulobacter spp. That Encode Niche-Specific Biosynthetic Gene Clusters.	Gutierrez-Garcia K, Bustos-Diaz ED, Corona-Gomez JA, Ramos-Aboites HE, Selem-Mojica N, Cruz-Morales P, Perez-Farrera MA, Barona-Gomez F, Cibrian-Jaramillo A.	Genome Biol Evol	10.1093/gbe/evy266	2019
Metabolism	Membrane interaction of Pasteurella multocida toxin involves sphingomyelin.	Brothers MC, Ho M, Maharjan R, Clemons NC, Bannai Y, Waites MA, Faulkner MJ, Kuhlenschmidt TB, Kuhlenschmidt MS, Blanke SR, Rienstra CM, Wilson BA.	FEBS J	10.1111/j.1742-4658.2011.08365.x	2011
Metabolism	Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics.	Sosio M, Gaspari E, Iorio M, Pessina S, Medema MH, Bernasconi A, Simone M, Maffioli SI, Ebright RH, Donadio S.	Cell Chem Biol	10.1016/j.chembiol.2018.02.008	2018
Pathogenicity	Pseudomonas aeruginosa cytotoxin: the influence of sphingomyelin on binding and cation permeability increase in mammalian erythrocytes.	Crowell KM, Lutz F.	Toxicon	10.1016/0041-0101(89)90114-1	1989
	Mixed-chain phosphatidylcholine analogues modified in the choline moiety: preparation of isomerically pure phospholipids with bulky head groups and one acyl chain twice as long as the other.	Ali S, Bittman R.	Chem Phys Lipids	10.1016/0009-3084(89)90022-4	1989
Metabolism	Evidence for a protein kinase C-directed mechanism in the phorbol diester-induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine.	Cabot MC, Welsh CJ, Zhang ZC, Cao HT.	FEBS Lett	10.1016/0014-5793(89)80197-8	1989
Metabolism	Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells. Possible role in signal transduction.	Liscovitch M, Amsterdam A.	J Biol Chem	10.1016/s0021-9258(18)80131-4	1989
Pathogenicity	The role of phospholipase D in osteoblast response to titanium surface microstructure.	Fang M, Olivares-Navarrete R, Wieland M, Cochran DL, Boyan BD, Schwartz Z.	J Biomed Mater Res A	10.1002/jbm.a.32596	2010
Metabolism	The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.	Chidley C, Trauger SA, Birsoy K, O'Shea EK.	Elife	10.7554/elife.14601	2016
Metabolism	Trehalose Accumulation Triggers Autophagy during Plant Desiccation.	Williams B, Njaci I, Moghaddam L, Long H, Dickman MB, Zhang X, Mundree S.	PLoS Genet	10.1371/journal.pgen.1005705	2015
Pathogenicity	Phospholipase D produces increased contractile force in rabbit ventricular muscle.	Langer GA, Rich TL.	Circ Res	10.1161/01.res.56.1.146	1985
	Characterization of mutant serine palmitoyltransferase 1 in LY-B cells.	Momin AA, Park H, Allegood JC, Leipelt M, Kelly SL, Merrill AH, Hanada K.	Lipids	10.1007/s11745-009-3316-4	2009
	Enzymatic measurement of phosphatidylserine in cultured cells.	Morita SY, Shirakawa S, Kobayashi Y, Nakamura K, Teraoka R, Kitagawa S, Terada T.	J Lipid Res	10.1194/jlr.d021808	2012
Metabolism	Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.	Frondorf K, Henkels KM, Frohman MA, Gomez-Cambronero J.	J Biol Chem	10.1074/jbc.m109.070524	2010
Metabolism	Hydrolysis of N-acylated glycerophospholipids by phospholipases A2 and D: a method of identification and analysis.	Schmid PC, Natarajan V, Weis BK, Schmid HH.	Chem Phys Lipids	10.1016/0009-3084(86)90022-8	1986
Pathogenicity	Miltefosine affects lipid metabolism in Leishmania donovani promastigotes.	Rakotomanga M, Blanc S, Gaudin K, Chaminade P, Loiseau PM.	Antimicrob Agents Chemother	10.1128/aac.01123-06	2007
Metabolism	Dipalmitoyl-phosphatidylcholine/phospholipase D interactions investigated with polarization-modulated infrared reflection absorption spectroscopy.	Estrela-Lopis I, Brezesinski G, Mohwald H.	Biophys J	10.1016/s0006-3495(01)76054-7	2001
Enzymology	Purification of Streptomyces chromofuscus phospholipase D by hydrophobic affinity chromatography on palmitoyl cellulose.	Imamura S, Horiuti Y.	J Biochem	10.1093/oxfordjournals.jbchem.a132334	1979
Metabolism	Experimental approaches to the study of A2E, a bisretinoid lipofuscin chromophore of retinal pigment epithelium.	Sparrow JR, Kim SR, Wu Y.	Methods Mol Biol	10.1007/978-1-60327-325-1_18	2010
	Asymmetric manipulation of the membrane lipid bilayer of intact human erythrocytes with phospholipase A, C, or D induces a change in cell shape.	Fujii T, Tamura A.	J Biochem	10.1093/oxfordjournals.jbchem.a132651	1979
	Topological location and biological significance of phospholipids in the membrane of Newcastle disease virus. Hydrolysis of phospholipids in intact virion with pure phospholipases A2, C, and D.	Suzuki Y, Maeda A, Matsumoto M.	J Biochem	10.1093/oxfordjournals.jbchem.a133966	1982
Metabolism	Acinetobacter baumannii Virulence Is Mediated by the Concerted Action of Three Phospholipases D.	Stahl J, Bergmann H, Gottig S, Ebersberger I, Averhoff B.	PLoS One	10.1371/journal.pone.0138360	2015
Pathogenicity	A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension.	Saga H, Ohhata A, Hayashi A, Katoh M, Maeda T, Mizuno H, Takada Y, Komichi Y, Ota H, Matsumura N, Shibaya M, Sugiyama T, Nakade S, Kishikawa K.	PLoS One	10.1371/journal.pone.0093230	2014
	Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound.	Karthik L, Kumar G, Keswani T, Bhattacharyya A, Chandar SS, Bhaskara Rao KV.	PLoS One	10.1371/journal.pone.0090972	2014
Enzymology	In vivo detection of phospholipase C by enzyme-activated near-infrared probes.	Mawn TM, Popov AV, Beardsley NJ, Stefflova K, Milkevitch M, Zheng G, Delikatny EJ.	Bioconjug Chem	10.1021/bc200242v	2011
Enzymology	Phosphohydrolase and transphosphatidylation reactions of two Streptomyces phospholipase D enzymes: covalent versus noncovalent catalysis.	Yang H, Roberts MF.	Protein Sci	10.1110/ps.03192503	2003
Metabolism	New pathway for degradation of sulfonated azo dyes by microbial peroxidases of Phanerochaete chrysosporium and Streptomyces chromofuscus.	Goszczynski S, Paszczynski A, Pasti-Grigsby MB, Crawford RL, Crawford DL.	J Bacteriol	10.1128/jb.176.5.1339-1347.1994	1994
	Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis.	Tokumura A, Carbone LD, Yoshioka Y, Morishige J, Kikuchi M, Postlethwaite A, Watsky MA.	Int J Med Sci	10.7150/ijms.6.168	2009
Metabolism	Mineralization of sulfonated azo dyes and sulfanilic acid by Phanerochaete chrysosporium and Streptomyces chromofuscus.	Paszczynski A, Pasti-Grigsby MB, Goszczynski S, Crawford RL, Crawford DL.	Appl Environ Microbiol	10.1128/aem.58.11.3598-3604.1992	1992
Enzymology	Molecular cloning, heterologous expression, and enzymatic characterization of lysoplasmalogen-specific phospholipase D from Thermocrispum sp.	Matsumoto Y, Kashiwabara N, Oyama T, Murayama K, Matsumoto H, Sakasegawa SI, Sugimori D.	FEBS Open Bio	10.1002/2211-5463.12131	2016
	A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification.	Saulnier-Blache JS, Girard A, Simon MF, Lafontan M, Valet P.	J Lipid Res	10.1016/s0022-2275(20)32355-5	2000
Metabolism	Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells.	Qin H, Frohman MA, Bollag WB.	Endocrinology	10.1210/en.2009-1159	2010
Metabolism	Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.	Ha KS, Exton JH.	J Cell Biol	10.1083/jcb.123.6.1789	1993
Metabolism	Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells.	Kaszkin M, Richards J, Kinzel V.	Biochem J	10.1042/bj3140129	1996
Metabolism	Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.	Agrotis A, Pengo N, Burden JJ, Ketteler R.	Autophagy	10.1080/15548627.2019.1569925	2019
Metabolism	Electrospray ionization mass spectrometry analysis of changes in phospholipids in RBL-2H3 mastocytoma cells during degranulation.	Ivanova PT, Cerda BA, Horn DM, Cohen JS, McLafferty FW, Brown HA.	Proc Natl Acad Sci U S A	10.1073/pnas.131195098	2001
Enzymology	Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.	Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, Kuijpers ME, Boesl M, Chen Q, Heemskerk JW, Stoll G, Frohman MA, Nieswandt B.	Sci Signal	10.1126/scisignal.2000551	2010
Metabolism	On the importance of the phosphocholine methyl groups for sphingomyelin/cholesterol interactions in membranes: a study with ceramide phosphoethanolamine.	Terova B, Heczko R, Slotte JP.	Biophys J	10.1529/biophysj.104.058149	2005
Metabolism	Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells.	Li J, Yao K, Yu X, Dong X, Gan L, Luo C, Wu Y.	J Biol Chem	10.1074/jbc.m113.511386	2013
Metabolism	Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity.	Mazereeuw-Hautier J, Gres S, Fanguin M, Cariven C, Fauvel J, Perret B, Chap H, Salles JP, Saulnier-Blache JS.	J Invest Dermatol	10.1111/j.0022-202x.2005.23855.x	2005
Metabolism	Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis.	Gesta S, Simon MF, Rey A, Sibrac D, Girard A, Lafontan M, Valet P, Saulnier-Blache JS.	J Lipid Res	10.1016/s0022-2275(20)30464-8	2002
	Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules.	Ghosh AK, Brindisi M.	RSC Adv	10.1039/c6ra22611f	2016
Metabolism	Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis.	Kuzuyama T, Seto H.	Proc Jpn Acad Ser B Phys Biol Sci	10.2183/pjab.88.41	2012
	A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines.	Guo L, Amarnath V, Davies SS.	Anal Biochem	10.1016/j.ab.2010.06.027	2010
Enzymology	Discovery and characterization of an Arabidopsis thaliana N-acylphosphatidylethanolamine synthase.	Faure L, Coulon D, Laroche-Traineau J, Le Guedard M, Schmitter JM, Testet E, Lessire R, Bessoule JJ.	J Biol Chem	10.1074/jbc.m109.005744	2009
Metabolism	Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.	Haynes CA, Allegood JC, Wang EW, Kelly SL, Sullards MC, Merrill AH.	J Lipid Res	10.1194/jlr.d015586	2011
Metabolism	Cloning, overexpression, and characterization of a bacterial Ca2+-dependent phospholipase D.	Yang H, Roberts MF.	Protein Sci	10.1110/ps.0225302	2002
Metabolism	Phosphatidylethanolamines modified by gamma-ketoaldehyde (gammaKA) induce endoplasmic reticulum stress and endothelial activation.	Guo L, Chen Z, Cox BE, Amarnath V, Epand RF, Epand RM, Davies SS.	J Biol Chem	10.1074/jbc.m110.213470	2011
Metabolism	Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.	Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV.	J Virol	10.1128/jvi.01087-15	2015
Metabolism	A biosynthetic pathway for anandamide.	Liu J, Wang L, Harvey-White J, Osei-Hyiaman D, Razdan R, Gong Q, Chan AC, Zhou Z, Huang BX, Kim HY, Kunos G.	Proc Natl Acad Sci U S A	10.1073/pnas.0601832103	2006
	The Vacuolar Protein Sorting-38 Subunit of the Arabidopsis Phosphatidylinositol-3-Kinase Complex Plays Critical Roles in Autophagy, Endosome Sorting, and Gravitropism.	Liu F, Hu W, Vierstra RD.	Front Plant Sci	10.3389/fpls.2018.00781	2018
	A kinetic model for chain length modulation of Streptococcus pneumoniae cellubiuronan capsular polysaccharide by nucleotide sugar donor concentrations.	Forsee WT, Cartee RT, Yother J.	J Biol Chem	10.1074/jbc.m900379200	2009
Metabolism	Activation of phospholipase D is tightly coupled to the phagocytosis of Mycobacterium tuberculosis or opsonized zymosan by human macrophages.	Kusner DJ, Hall CF, Schlesinger LS.	J Exp Med	10.1084/jem.184.2.585	1996
Metabolism	Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines.	Okamoto Y, Morishita J, Wang J, Schmid PC, Krebsbach RJ, Schmid HH, Ueda N.	Biochem J	10.1042/bj20041790	2005
Metabolism	Phosphatidic acid modulation of Kv channel voltage sensor function.	Hite RK, Butterwick JA, MacKinnon R.	Elife	10.7554/elife.04366	2014
Metabolism	Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion.	Vicogne J, Vollenweider D, Smith JR, Huang P, Frohman MA, Pessin JE.	Proc Natl Acad Sci U S A	10.1073/pnas.0606881103	2006
Metabolism	Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.	Tsukahara T, Tsukahara R, Fujiwara Y, Yue J, Cheng Y, Guo H, Bolen A, Zhang C, Balazs L, Re F, Du G, Frohman MA, Baker DL, Parrill AL, Uchiyama A, Kobayashi T, Murakami-Murofushi K, Tigyi G.	Mol Cell	10.1016/j.molcel.2010.07.022	2010
Enzymology	Putative N-acylphosphatidylethanolamine synthase from Arabidopsis thaliana is a lysoglycerophospholipid acyltransferase.	Bulat E, Garrett TA.	J Biol Chem	10.1074/jbc.m111.269779	2011
Metabolism	Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function.	Metz SA, Dunlop M.	Biochem J	10.1042/bj2700427	1990
Metabolism	The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells.	Ljubicic S, Bezzi P, Vitale N, Regazzi R.	PLoS One	10.1371/journal.pone.0007770	2009
Metabolism	Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease.	Wu Y, Fishkin NE, Pande A, Pande J, Sparrow JR.	J Biol Chem	10.1074/jbc.m109.021345	2009
	Characterization of the lipid linkage region and chain length of the cellubiuronic acid capsule of Streptococcus pneumoniae.	Forsee WT, Cartee RT, Yother J.	J Biol Chem	10.1074/jbc.m900386200	2009
	Packing and electrostatic behavior of sn-2-docosahexaenoyl and -arachidonoyl phosphoglycerides.	Brockman HL, Applegate KR, Momsen MM, King WC, Glomset JA.	Biophys J	10.1016/s0006-3495(03)74662-1	2003
Metabolism	ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.	Pelletan LE, Suhaiman L, Vaquer CC, Bustos MA, De Blas GA, Vitale N, Mayorga LS, Belmonte SA.	J Biol Chem	10.1074/jbc.m114.629006	2015
Metabolism	Endocannabinoids link feeding state and auditory perception-related gene expression.	Soderstrom K, Tian Q, Valenti M, Di Marzo V.	J Neurosci	10.1523/jneurosci.3298-04.2004	2004
Metabolism	Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation.	Schmid PC, Paria BC, Krebsbach RJ, Schmid HH, Dey SK.	Proc Natl Acad Sci U S A	10.1073/pnas.94.8.4188	1997
Metabolism	CpsE from type 2 Streptococcus pneumoniae catalyzes the reversible addition of glucose-1-phosphate to a polyprenyl phosphate acceptor, initiating type 2 capsule repeat unit formation.	Cartee RT, Forsee WT, Bender MH, Ambrose KD, Yother J.	J Bacteriol	10.1128/jb.187.21.7425-7433.2005	2005
Metabolism	Initiation and synthesis of the Streptococcus pneumoniae type 3 capsule on a phosphatidylglycerol membrane anchor.	Cartee RT, Forsee WT, Yother J.	J Bacteriol	10.1128/jb.187.13.4470-4479.2005	2005
Enzymology	Gonococcal phospholipase d modulates the expression and function of complement receptor 3 in primary cervical epithelial cells.	Edwards JL, Entz DD, Apicella MA.	Infect Immun	10.1128/iai.71.11.6381-6391.2003	2003
Metabolism	Translocation and surface expression of lipidated serogroup B capsular Polysaccharide in Neisseria meningitidis.	Tzeng YL, Datta AK, Strole CA, Lobritz MA, Carlson RW, Stephens DS.	Infect Immun	10.1128/iai.73.3.1491-1505.2005	2005
Metabolism	Effect of tricyclodecan-9-yl potassium xanthate (D609) on phospholipid metabolism and cell death during oxygen-glucose deprivation in PC12 cells.	Larsen EC, Hatcher JF, Adibhatla RM.	Neuroscience	10.1016/j.neuroscience.2007.02.022	2007
Metabolism	Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network.	Chen YG, Siddhanta A, Austin CD, Hammond SM, Sung TC, Frohman MA, Morris AJ, Shields D.	J Cell Biol	10.1083/jcb.138.3.495	1997
Metabolism	Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.	Cadas H, di Tomaso E, Piomelli D.	J Neurosci	10.1523/jneurosci.17-04-01226.1997	1997
	Streptomyces flavusporus sp. nov., a Novel Actinomycete Isolated from Naidong, Xizang (Tibet), China.	Tang D, Zhou X, Qian H, Jiao Y, Wang Y.	Microorganisms	10.3390/microorganisms13051001	2025
Phylogeny	Streptomyces bullii sp. nov., isolated from a hyper-arid Atacama Desert soil.	Santhanam R, Rong X, Huang Y, Andrews BA, Asenjo JA, Goodfellow M.	Antonie Van Leeuwenhoek	10.1007/s10482-012-9816-x	2013
Phylogeny	Streptomyces gossypiisoli sp. nov., isolated from cotton soil in Xinjiang, PR China.	Zhang QY, Qin S, Luo XX, Xia ZF	Int J Syst Evol Microbiol	10.1099/ijsem.0.004561	2020
Phylogeny	Streptomyces ferrugineus sp. nov., isolated from mangrove soil in Thailand.	Ruan CY, Zhang L, Ye WW, Xie XC, Srivibool R, Duangmal K, Pathom-aree W, Deng ZX, Hong K	Antonie Van Leeuwenhoek	10.1007/s10482-014-0301-6	2014
Phylogeny	Streptomyces chiangmaiensis sp. nov. and Streptomyces lannensis sp. nov., isolated from the South-East Asian stingless bee (Tetragonilla collina).	Promnuan Y, Kudo T, Ohkuma M, Chantawannakul P	Int J Syst Evol Microbiol	10.1099/ijs.0.045930-0	2012