Burkholderia multivorans (CCUG 37245, ATCC 17616, LMG 17588)

Name: Burkholderia multivorans (CCUG 37245, ATCC 17616, LMG 17588)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 149192

Type strain

Culture col. no. CCUG 37245 ATCC 17616 LMG 17588

NCBI tax ID(s) 395019 87883

Special Collections CCUG

Links

Burkholderia multivorans CCUG 37245 is a prokaryote that was isolated from Soil enriched with anthranilate at 41°C.

genome sequence 16S sequence

Name and taxonomic classification

SI-ID 10077

LMG 17588,ATCC 17616,LMD 70.83,NCCB 70083,CCUG 37245

@ref 20215

Last LPSN update 2025-12-16 10:05:47

Domain Pseudomonadati

Phylum Pseudomonadota

Class Betaproteobacteria

Order Burkholderiales

Family Burkholderiaceae

Genus Burkholderia

Species Burkholderia multivorans

Full scientific name Burkholderia multivorans Vandamme et al. 1997

BacDive ID	Other strains from **Burkholderia multivorans** (59)	Type strain
1941	B. multivorans Cepa 002, DSM 13243, CIP 105495, LMG 13010, ... (type strain)
143845	B. multivorans CCUG 21496
147066	B. multivorans CCUG 32783
147752	B. multivorans CCUG 34167, LMG 14293
147874	B. multivorans CCUG 34415, LMG 16229
147895	B. multivorans CCUG 34449, LMG 16231
148354	B. multivorans CCUG 35274
148425	B. multivorans CCUG 35415
148766	B. multivorans CCUG 35916
148800	B. multivorans CCUG 35953
148896	B. multivorans CCUG 36562 B, LMG R-923
149163	B. multivorans CCUG 36978, LMG R1050
149188	B. multivorans CCUG 37240, LMG 16665
149189	B. multivorans CCUG 37242, LMG 16775
149190	B. multivorans CCUG 37243, LMG 17567
149191	B. multivorans CCUG 37244, LMG 17568
149903	B. multivorans CCUG 38651
150291	B. multivorans CCUG 39522
150446	B. multivorans CCUG 39953
150532	B. multivorans CCUG 41506
150716	B. multivorans CCUG 42036
150887	B. multivorans CCUG 42629
151040	B. multivorans CCUG 43127
151232	B. multivorans CCUG 43517
151265	B. multivorans CCUG 43584
151314	B. multivorans CCUG 43728
151774	B. multivorans CCUG 44838
151942	B. multivorans CCUG 45292
152017	B. multivorans CCUG 45557
152182	B. multivorans CCUG 45989
152236	B. multivorans CCUG 46187
152308	B. multivorans CCUG 46394
152396	B. multivorans CCUG 46669
152488	B. multivorans CCUG 46920
152547	B. multivorans CCUG 47036
152560	B. multivorans CCUG 47053
152629	B. multivorans CCUG 47232
152957	B. multivorans CCUG 48126
153398	B. multivorans CCUG 49473
153719	B. multivorans CCUG 50736
153953	B. multivorans CCUG 51751
154030	B. multivorans CCUG 52053
154337	B. multivorans CCUG 53168
154402	B. multivorans CCUG 53408
154741	B. multivorans CCUG 55067
154909	B. multivorans CCUG 55646
154910	B. multivorans CCUG 55647
155261	B. multivorans CCUG 57130
155343	B. multivorans CCUG 57397
155412	B. multivorans CCUG 57653
155727	B. multivorans CCUG 59151
156052	B. multivorans CCUG 60225
156055	B. multivorans CCUG 60232
156195	B. multivorans CCUG 60686
156278	B. multivorans CCUG 61010
156349	B. multivorans CCUG 61252
156391	B. multivorans CCUG 61527
156422	B. multivorans CCUG 61674
175055	B. multivorans 114287, DSM 114287

Morphology

Cell morphology

@ref	Gram stain	Confidence
125438	negative	97.5
125439	negative	97

Culture and growth conditions

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	aerobe	91.398
125439	obligate aerobe	99.4

Spore formation

@ref	Spore formation	Confidence
125439		96.7

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	acetate fermentation	100	4 of 4
66794	denitrification	100	2 of 2
66794	starch degradation	100	10 of 10
66794	ppGpp biosynthesis	100	4 of 4
66794	lactate fermentation	100	4 of 4
66794	suberin monomers biosynthesis	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	ceramide biosynthesis	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	biotin biosynthesis	100	4 of 4
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	adipate degradation	100	2 of 2
66794	gallate degradation	100	5 of 5
66794	L-lactaldehyde degradation	100	3 of 3
66794	octane oxidation	100	3 of 3
66794	cardiolipin biosynthesis	100	7 of 7
66794	vitamin B6 metabolism	100	11 of 11
66794	valine metabolism	100	9 of 9
66794	folate polyglutamylation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	Entner Doudoroff pathway	100	10 of 10
66794	formaldehyde oxidation	100	3 of 3
66794	resorcinol degradation	100	2 of 2
66794	butanoate fermentation	100	4 of 4
66794	ubiquinone biosynthesis	100	7 of 7
66794	coenzyme A metabolism	100	4 of 4
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	methylglyoxal degradation	100	5 of 5
66794	sulfopterin metabolism	100	4 of 4
66794	4-hydroxymandelate degradation	100	9 of 9
66794	aerobactin biosynthesis	100	1 of 1
66794	tetrahydrofolate metabolism	92.86	13 of 14
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	vitamin B12 metabolism	91.18	31 of 34
66794	pentose phosphate pathway	90.91	10 of 11
66794	proline metabolism	90.91	10 of 11
66794	4-hydroxyphenylacetate degradation	90	9 of 10
66794	alanine metabolism	89.66	26 of 29
66794	allantoin degradation	88.89	8 of 9
66794	lipid A biosynthesis	88.89	8 of 9
66794	serine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	NAD metabolism	88.89	16 of 18
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	heme metabolism	85.71	12 of 14
66794	glutamate and glutamine metabolism	85.71	24 of 28
66794	photosynthesis	85.71	12 of 14
66794	citric acid cycle	85.71	12 of 14
66794	propanol degradation	85.71	6 of 7
66794	phenol degradation	85	17 of 20
66794	vitamin B1 metabolism	84.62	11 of 13
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	tryptophan metabolism	81.58	31 of 38
66794	myo-inositol biosynthesis	80	8 of 10
66794	3-chlorocatechol degradation	80	4 of 5
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	3-phenylpropionate degradation	80	12 of 15
66794	hydrogen production	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	arginine metabolism	79.17	19 of 24
66794	glutathione metabolism	78.57	11 of 14
66794	d-mannose degradation	77.78	7 of 9
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	purine metabolism	77.66	73 of 94
66794	urea cycle	76.92	10 of 13
66794	glycolysis	76.47	13 of 17
66794	lysine metabolism	76.19	32 of 42
66794	degradation of sugar acids	76	19 of 25
66794	cyclohexanol degradation	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	glycogen biosynthesis	75	3 of 4
66794	CMP-KDO biosynthesis	75	3 of 4
66794	toluene degradation	75	3 of 4
66794	ketogluconate metabolism	75	6 of 8
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	pyrimidine metabolism	73.33	33 of 45
66794	histidine metabolism	72.41	21 of 29
66794	cysteine metabolism	72.22	13 of 18
66794	tyrosine metabolism	71.43	10 of 14
66794	degradation of pentoses	71.43	20 of 28
66794	oxidative phosphorylation	70.33	64 of 91
66794	propionate fermentation	70	7 of 10
66794	methionine metabolism	69.23	18 of 26
66794	androgen and estrogen metabolism	68.75	11 of 16
66794	non-pathway related	68.42	26 of 38
66794	lipid metabolism	67.74	21 of 31
66794	glycolate and glyoxylate degradation	66.67	4 of 6
66794	acetoin degradation	66.67	2 of 3
66794	flavin biosynthesis	66.67	10 of 15
66794	methane metabolism	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
66794	cyanate degradation	66.67	2 of 3
66794	polyamine pathway	65.22	15 of 23
66794	metabolism of disaccharids	63.64	7 of 11
66794	dTDPLrhamnose biosynthesis	62.5	5 of 8
66794	degradation of sugar alcohols	62.5	10 of 16
66794	isoprenoid biosynthesis	61.54	16 of 26
66794	sulfate reduction	61.54	8 of 13
66794	cellulose degradation	60	3 of 5
66794	vitamin K metabolism	60	3 of 5
66794	lipoate biosynthesis	60	3 of 5
66794	nitrate assimilation	55.56	5 of 9
66794	chlorophyll metabolism	55.56	10 of 18
66794	bile acid biosynthesis, neutral pathway	52.94	9 of 17
66794	degradation of hexoses	50	9 of 18
66794	coenzyme M biosynthesis	50	5 of 10
66794	glycine metabolism	50	5 of 10
66794	phenylmercury acetate degradation	50	1 of 2
66794	quinate degradation	50	1 of 2
66794	ribulose monophosphate pathway	50	1 of 2
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	phenylpropanoid biosynthesis	46.15	6 of 13
66794	d-xylose degradation	45.45	5 of 11
66794	carotenoid biosynthesis	45.45	10 of 22
66794	cholesterol biosynthesis	45.45	5 of 11
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	metabolism of amino sugars and derivatives	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	glycine betaine biosynthesis	40	2 of 5
66794	creatinine degradation	40	2 of 5
66794	factor 420 biosynthesis	40	2 of 5
66794	arachidonic acid metabolism	38.89	7 of 18
66794	carnitine metabolism	37.5	3 of 8
66794	sphingosine metabolism	33.33	2 of 6
66794	sulfoquinovose degradation	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	ascorbate metabolism	31.82	7 of 22
66794	aclacinomycin biosynthesis	28.57	2 of 7
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	vitamin E metabolism	25	1 of 4
66794	alginate biosynthesis	25	1 of 4
66794	phosphatidylethanolamine bioynthesis	23.08	3 of 13
66794	daunorubicin biosynthesis	22.22	2 of 9

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Laboratory	#Lab enrichment
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
53550	Soil enriched with anthranilate at 41°C	California,Berkeley	USA	USA	North America

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1054v1 assembly for Burkholderia multivorans ATCC 17616	complete	GCA_000010545	395019.7	642555111	395019	98.44
66792	ASM1850v1 assembly for Burkholderia multivorans ATCC 17616	complete	GCA_000018505	395019.8	641228482	395019	98.42

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Burkholderia multivorans gene for 16S rRNA, partial sequence.	AB092606	1485		395019

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Burkholderia multivorans ATCC 17616
NCBI: GCA_000010545

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	96.70	no
125439	motility	BacteriaNetⓘ	yes	73.40	no
125439	gram_stain	BacteriaNetⓘ	negative	97.00	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Burkholderia multivorans ATCC 17616 ATCC 17616
NCBI: GCA_000010545.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	97.50	no
125438	anaerobic	anaerobicⓘ	no	97.13	no
125438	aerobic	aerobicⓘ	yes	91.40	no
125438	spore-forming	spore-formingⓘ	no	87.81	no
125438	thermophilic	thermophileⓘ	no	97.50	no
125438	flagellated	motile2+ⓘ	yes	81.33	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Pulmonary microbial spectrum of Burkholderia multivorans infection identified by metagenomic sequencing.	Xu H, Zhang R, Zhang X, Zhang Z, Feng Y, Lin L.	Front Med (Lausanne)	10.3389/fmed.2025.1577363	2025
	Frameshift Mutations in Genes Encoding PBP3 and PBP4 Trigger an Unusual, Extreme beta-Lactam Resistance Phenotype in Burkholderia multivorans.	Mojica MF, Nukaga M, Becka SA, Zeiser ET, Hoshino T, LiPuma JJ, Papp-Wallace KM.	ACS Infect Dis	10.1021/acsinfecdis.4c00330	2024
Genetics	Genomic editing in Burkholderia multivorans by CRISPR/Cas9.	Ferreira MR, Queiroga V, Moreira LM.	Appl Environ Microbiol	10.1128/aem.02250-23	2024
	A CRISPR-Cas-associated transposon system for genome editing in Burkholderia cepacia complex species.	Yap ZL, Rahman ASMZ, Hogan AM, Levin DB, Cardona ST.	Appl Environ Microbiol	10.1128/aem.00699-24	2024
	Disparate properties of Burkholderia multivorans and Pseudomonas aeruginosa regarding outer membrane chemical permeabilization to the hydrophobic substances novobiocin and triclosan.	Ruskoski SA, McDonald AA, Bleichner JJ, Aga SS, Boyina K, Champlin FR.	PLoS One	10.1371/journal.pone.0284855	2023
Phenotype	Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogen Burkholderia multivorans.	Parfitt KM, Green AE, Connor TR, Neill DR, Mahenthiralingam E.	Microbiology (Reading)	10.1099/mic.0.001366	2023
	Activity of ETX0462 toward Some Burkholderia spp.	Zeiser ET, Becka SA, LiPuma JJ, Papp-Wallace KM.	Antimicrob Agents Chemother	10.1128/aac.01352-22	2023
Biotechnology	Mechanisms of Arsenic Interaction in Bacillus subtilis and Related Species with Biotechnological Potential.	Valenzuela-Garcia LI, Alarcon-Herrera MT, Cisneros-Lozano E, Pedraza-Reyes M, Ayala-Garcia VM.	Int J Mol Sci	10.3390/ijms262110277	2025
Genetics	Distribution, characterization, and evolution of heavy metal resistance genes and Tn7-like associated heavy metal resistance Gene Island of Burkholderia.	Lan Y, Liu M, Song Y, Cao Y, Li F, Luo D, Qiao D.	Front Microbiol	10.3389/fmicb.2023.1252127	2023
	Activity of Imipenem-Relebactam against Multidrug- and Extensively Drug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli.	Becka SA, Zeiser ET, LiPuma JJ, Papp-Wallace KM.	Antimicrob Agents Chemother	10.1128/aac.01332-21	2021
	Examining the activity of cefepime-taniborbactam against Burkholderia cepacia complex and Burkholderia gladioli isolated from cystic fibrosis patients in the United States.	Mojica MF, Zeiser ET, Becka SA, LiPuma JJ, Six DA, Moeck G, Papp-Wallace KM.	Antimicrob Agents Chemother	10.1128/aac.00498-23	2023
	The phytopathogen Xanthomonas campestris senses and effluxes salicylic acid via a sensor HepR and an RND family efflux pump to promote virulence in host plants.	Song K, Li R, Cui Y, Chen B, Zhou L, Han W, Jiang BL, He YW.	mLife	10.1002/mlf2.12140	2024
Genetics	Bacterial genome-encoded ParMs.	Ali S, Koh A, Popp D, Tanaka K, Kitaoku Y, Miyazaki N, Iwasaki K, Mitsuoka K, Robinson RC, Narita A.	J Biol Chem	10.1016/j.jbc.2025.110351	2025
	Subtractive sequence analysis aided druggable targets mining in Burkholderia cepacia complex and finding inhibitors through bioinformatics approach.	Hassan SS, Shams R, Camps I, Basharat Z, Sohail S, Khan Y, Ullah A, Irfan M, Ali J, Bilal M, Morel CM.	Mol Divers	10.1007/s11030-022-10584-5	2023
	Sequence heterogeneity of the PenA carbapenemase in clinical isolates of Burkholderia multivorans.	Becka SA, Zeiser ET, Marshall SH, Gatta JA, Nguyen K, Singh I, Greco C, Sutton GG, Fouts DE, LiPuma JJ, Papp-Wallace KM.	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2018.06.005	2018
	The Small RNA NcS25 Regulates Biological Amine-Transporting Outer Membrane Porin BCAL3473 in Burkholderia cenocepacia.	Sass AM, Coenye T.	mSphere	10.1128/msphere.00083-23	2023
	A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.	Diaz Caballero J, Clark ST, Wang PW, Donaldson SL, Coburn B, Tullis DE, Yau YCW, Waters VJ, Hwang DM, Guttman DS.	PLoS Pathog	10.1371/journal.ppat.1007453	2018
	Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity.	Lood C, Peeters C, Lamy-Besnier Q, Wagemans J, De Vos D, Proesmans M, Pirnay JP, Echahidi F, Pierard D, Thimmesch M, Boeras A, Lagrou K, De Canck E, De Wachter E, van Noort V, Lavigne R, Vandamme P.	PLoS Pathog	10.1371/journal.ppat.1009418	2021
Enzymology	Regulator LdhR and d-Lactate Dehydrogenase LdhA of Burkholderia multivorans Play Roles in Carbon Overflow and in Planktonic Cellular Aggregate Formation.	Silva IN, Ramires MJ, Azevedo LA, Guerreiro AR, Tavares AC, Becker JD, Moreira LM.	Appl Environ Microbiol	10.1128/aem.01343-17	2017
	The Isolation and Characterization of a Broad Host Range Bcep22-like Podovirus JC1.	Davis CM, Ruest MK, Cole JH, Dennis JJ.	Viruses	10.3390/v14050938	2022
	Phenazines and toxoflavin act as interspecies modulators of resilience to diverse antibiotics.	Meirelles LA, Newman DK.	Mol Microbiol	10.1111/mmi.14915	2022
	Characterization and optimization of schizophyllan production from date syrup.	Jamshidian H, Shojaosadati SA, Vilaplana F, Mousavi SM, Soudi MR.	Int J Biol Macromol	10.1016/j.ijbiomac.2016.07.059	2016
Metabolism	Role and Function of Class III LitR, a Photosensor Homolog from Burkholderia multivorans.	Sumi S, Shiratori-Takano H, Ueda K, Takano H.	J Bacteriol	10.1128/jb.00285-18	2018
	Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure.	Peeters C, Cooper VS, Hatcher PJ, Verheyde B, Carlier A, Vandamme P.	PLoS One	10.1371/journal.pone.0176191	2017
	Identification and characterization of Burkholderia multivorans CCA53.	Akita H, Kimura ZI, Yusoff MZM, Nakashima N, Hoshino T.	BMC Res Notes	10.1186/s13104-017-2565-1	2017
Pathogenicity	Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.	Cheung-Lee WL, Parry ME, Zong C, Cartagena AJ, Darst SA, Connell ND, Russo R, Link AJ.	Chembiochem	10.1002/cbic.201900707	2020
	Complete Genome Sequence of a Phenanthrene Degrader, Burkholderia sp. HB-1 (NBRC 110738).	Ohtsubo Y, Moriya A, Kato H, Ogawa N, Nagata Y, Tsuda M.	Genome Announc	10.1128/genomea.01283-15	2015
	Phenotypic and Genetic Characterization of Temperature-Induced Mutagenesis and Mortality in Cupriavidus metallidurans.	Van Houdt R, Vandecraen J, Heylen W, Leys N, Monsieurs P, Provoost A, Aertsen A.	Front Microbiol	10.3389/fmicb.2021.698330	2021
Enzymology	PCR detection of Burkholderia multivorans in water and soil samples.	Peeters C, Daenekindt S, Vandamme P.	BMC Microbiol	10.1186/s12866-016-0801-9	2016
	Burkholderia cepacia Complex Contact-Dependent Growth Inhibition Systems Mediate Interbacterial Competition.	Myers-Morales T, Oates AE, Byrd MS, Garcia EC.	J Bacteriol	10.1128/jb.00012-19	2019
Pathogenicity	Resurrecting Old beta-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States.	Zeiser ET, Becka SA, Barnes MD, Taracila MA, LiPuma JJ, Papp-Wallace KM.	Antimicrob Agents Chemother	10.1128/aac.02315-18	2019
	In-Silico Analysis Highlights the Existence in Members of Burkholderia cepacia Complex of a New Class of Adhesins Possessing Collagen-like Domains.	Estevens R, Mil-Homens D, Fialho AM.	Microorganisms	10.3390/microorganisms11051118	2023
	Improved Dynamic Range of a Rhamnose-Inducible Promoter for Gene Expression in Burkholderia spp.	Hogan AM, Jeffers KR, Palacios A, Cardona ST.	Appl Environ Microbiol	10.1128/aem.00647-21	2021
	Draft genome sequences of four Achromobacter ruhlandii strains isolated from cystic fibrosis patients.	Rodrigues ER, Rocha GA, Ferreira AG, Leao RS, Albano RM, Marques EA.	Mem Inst Oswaldo Cruz	10.1590/0074-02760160130	2016
	In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species.	Papp-Wallace KM, Shapiro AB, Becka SA, Zeiser ET, LiPuma JJ, Lane DJ, Panchal RG, Mueller JP, O'Donnell JP, Miller AA.	Antimicrob Agents Chemother	10.1128/aac.01930-20	2021
	Identification of a self-sufficient cytochrome P450 monooxygenase from Cupriavidus pinatubonensis JMP134 involved in 2-hydroxyphenylacetic acid catabolism, via homogentisate pathway.	Donoso RA, Ruiz D, Garate-Castro C, Villegas P, Gonzalez-Pastor JE, de Lorenzo V, Gonzalez B, Perez-Pantoja D.	Microb Biotechnol	10.1111/1751-7915.13865	2021
Phylogeny	Draft genome sequence determination for cystic fibrosis and chronic granulomatous disease Burkholderia multivorans isolates.	Varga JJ, Losada L, Zelazny AM, Brinkac L, Harkins D, Radune D, Hostetler J, Sampaio EP, Ronning CM, Nierman WC, Greenberg DE, Holland SM, Goldberg JB.	J Bacteriol	10.1128/jb.01306-12	2012
Phylogeny	Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complex.	Lynch KH, Stothard P, Dennis JJ, Dennis JJ.	BMC Genomics	10.1186/1471-2164-11-599	2010
	Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient.	Hassan AA, Maldonado RF, Dos Santos SC, Di Lorenzo F, Silipo A, Coutinho CP, Cooper VS, Molinaro A, Valvano MA, Sa-Correia I.	Front Microbiol	10.3389/fmicb.2017.01027	2017
Pathogenicity	Rocket-miR, a translational launchpad for miRNA-based antimicrobial drug development.	Neff SL, Hampton TH, Koeppen K, Sarkar S, Latario CJ, Ross BD, Stanton BA.	mSystems	10.1128/msystems.00653-23	2023
Pathogenicity	Pseudomonas aeruginosa-Derived Rhamnolipids and Other Detergents Modulate Colony Morphotype and Motility in the Burkholderia cepacia Complex.	Bernier SP, Hum C, Li X, O'Toole GA, Magarvey NA, Surette MG.	J Bacteriol	10.1128/jb.00171-17	2017
Metabolism	Burkholderia contaminans Biofilm Regulating Operon and Its Distribution in Bacterial Genomes.	Voronina OL, Kunda MS, Ryzhova NN, Aksenova EI, Semenov AN, Romanova YM, Gintsburg AL.	Biomed Res Int	10.1155/2016/6560534	2016
Genetics	Unravelling the antibiotic and heavy metal resistome of a chronically polluted soil.	Salam LB.	3 Biotech	10.1007/s13205-020-02219-z	2020
	Stress conditions triggering mucoid morphotype variation in Burkholderia species and effect on virulence in Galleria mellonella and biofilm formation in vitro.	Silva IN, Tavares AC, Ferreira AS, Moreira LM.	PLoS One	10.1371/journal.pone.0082522	2013
Pathogenicity	Fosmidomycin decreases membrane hopanoids and potentiates the effects of colistin on Burkholderia multivorans clinical isolates.	Malott RJ, Wu CH, Lee TD, Hird TJ, Dalleska NF, Zlosnik JE, Newman DK, Speert DP.	Antimicrob Agents Chemother	10.1128/aac.02705-14	2014
Metabolism	The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111.	Aguilar C, Schmid N, Lardi M, Pessi G, Eberl L.	PLoS One	10.1371/journal.pone.0092920	2014
Enzymology	Accurate identification and epidemiological characterization of Burkholderia cepacia complex: an update.	Devanga Ragupathi NK, Veeraraghavan B.	Ann Clin Microbiol Antimicrob	10.1186/s12941-019-0306-0	2019
	The OmpR Regulator of Burkholderia multivorans Controls Mucoid-to-Nonmucoid Transition and Other Cell Envelope Properties Associated with Persistence in the Cystic Fibrosis Lung.	Silva IN, Pessoa FD, Ramires MJ, Santos MR, Becker JD, Cooper VS, Moreira LM.	J Bacteriol	10.1128/jb.00216-18	2018
Phylogeny	Identification of potential diagnostic markers among Burkholderia cenocepacia and B. multivorans supernatants.	Mott T, Soler M, Grigsby S, Medley R, Whitlock GC.	J Clin Microbiol	10.1128/jcm.00577-10	2010
Metabolism	Involvement of two transport systems and a specific porin in the uptake of phthalate by Burkholderia spp.	Chang HK, Dennis JJ, Dennis JJ, Zylstra GJ.	J Bacteriol	10.1128/jb.00377-09	2009
Pathogenicity	Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection.	Silva IN, Santos PM, Santos MR, Zlosnik JE, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, Moreira LM.	mSystems	10.1128/msystems.00029-16	2016
	Knockout of a highly GC-rich gene in Burkholderia pyrrocinia by recombineering with freeze-thawing transformation.	Chen F, Ye J, Liu W, Chio C, Wang W, Qin W.	Mol Plant Pathol	10.1111/mpp.13058	2021
Metabolism	Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.	Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM.	Biochemistry	10.1021/bi3015554	2013
Metabolism	ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in Burkholderia thailandensis.	Le Guillouzer S, Groleau MC, Mauffrey F, Deziel E.	J Bacteriol	10.1128/jb.00776-19	2020
	The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth.	Van Acker H, Crabbe A, Jurenas D, Ostyn L, Sass A, Daled S, Dhaenens M, Deforce D, Teirlinck E, De Keersmaecker H, Braeckmans K, Van Melderen L, Coenye T.	Biofilm	10.1016/j.bioflm.2019.100001	2019
	Identification of acquired antimicrobial resistance genes.	Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, Aarestrup FM, Larsen MV.	J Antimicrob Chemother	10.1093/jac/dks261	2012
Genetics	Genomic characterization of JG068, a novel virulent podovirus active against Burkholderia cenocepacia.	Lynch KH, Abdu AH, Schobert M, Dennis JJ, Dennis JJ.	BMC Genomics	10.1186/1471-2164-14-574	2013
	GenomeMatcher: a graphical user interface for DNA sequence comparison.	Ohtsubo Y, Ikeda-Ohtsubo W, Nagata Y, Tsuda M.	BMC Bioinformatics	10.1186/1471-2105-9-376	2008
Metabolism	Characterization of the poly-beta-1,6-N-acetylglucosamine polysaccharide component of Burkholderia biofilms.	Yakandawala N, Gawande PV, LoVetri K, Cardona ST, Romeo T, Nitz M, Madhyastha S.	Appl Environ Microbiol	10.1128/aem.05814-11	2011
	Bacterial community and arsenic functional genes diversity in arsenic contaminated soils from different geographic locations.	Gu Y, D Van Nostrand J, Wu L, He Z, Qin Y, Zhao FJ, Zhou J.	PLoS One	10.1371/journal.pone.0176696	2017
	Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.	Ferreira AS, Leitao JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM.	Appl Environ Microbiol	10.1128/aem.01828-09	2010
Metabolism	The Siderophore Product Ornibactin Is Required for the Bactericidal Activity of Burkholderia contaminans MS14.	Deng P, Foxfire A, Xu J, Baird SM, Jia J, Delgado KH, Shin R, Smith L, Lu SE.	Appl Environ Microbiol	10.1128/aem.00051-17	2017
Pathogenicity	Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient Lung.	Hassan AA, Dos Santos SC, Cooper VS, Sa-Correia I.	Front Microbiol	10.3389/fmicb.2020.574626	2020
Phylogeny	Phylogeny of replication initiator protein TrfA reveals a highly divergent clade of incompatibility group P1 plasmids.	Stenger DC, Lee MW.	Appl Environ Microbiol	10.1128/aem.02789-10	2011
Enzymology	Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance.	Fan F, Ghanem M, Gadda G.	Arch Biochem Biophys	10.1016/j.abb.2003.10.003	2004
	Specific gene responses of Rhodococcus jostii RHA1 during growth in soil.	Iino T, Wang Y, Miyauchi K, Kasai D, Masai E, Fujii T, Ogawa N, Fukuda M.	Appl Environ Microbiol	10.1128/aem.00164-12	2012
	Purification and characterization of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3.	Kolvenbach BA, Lenz M, Benndorf D, Rapp E, Fousek J, Vlcek C, Schaffer A, Gabriel FL, Kohler HP, Corvini PF.	AMB Express	10.1186/2191-0855-1-8	2011
Pathogenicity	Virulence and cellular interactions of Burkholderia multivorans in chronic granulomatous disease.	Zelazny AM, Ding L, Elloumi HZ, Brinster LR, Benedetti F, Czapiga M, Ulrich RL, Ballentine SJ, Goldberg JB, Sampaio EP, Holland SM.	Infect Immun	10.1128/iai.00259-09	2009
Pathogenicity	Biocide susceptibility of the Burkholderia cepacia complex.	Rose H, Baldwin A, Dowson CG, Mahenthiralingam E.	J Antimicrob Chemother	10.1093/jac/dkn540	2009
Metabolism	Conjugal transfer of polychlorinated biphenyl/biphenyl degradation genes in Acidovorax sp. strain KKS102, which are located on an integrative and conjugative element.	Ohtsubo Y, Ishibashi Y, Naganawa H, Hirokawa S, Atobe S, Nagata Y, Tsuda M.	J Bacteriol	10.1128/jb.00352-12	2012
Pathogenicity	Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex.	Lauman P, Dennis JJ.	Viruses	10.3390/v13071331	2021
Genetics	Proteogenomic Analysis of Burkholderia Species Strains 25 and 46 Isolated from Uraniferous Soils Reveals Multiple Mechanisms to Cope with Uranium Stress.	Agarwal M, Pathak A, Rathore RS, Prakash O, Singh R, Jaswal R, Seaman J, Chauhan A.	Cells	10.3390/cells7120269	2018
Pathogenicity	In vitro activities of a novel nanoemulsion against Burkholderia and other multidrug-resistant cystic fibrosis-associated bacterial species.	LiPuma JJ, Rathinavelu S, Foster BK, Keoleian JC, Makidon PE, Kalikin LM, Baker JR.	Antimicrob Agents Chemother	10.1128/aac.00691-08	2009
	Xanthomonas hortorum - beyond gardens: Current taxonomy, genomics, and virulence repertoires.	Dia NC, Moriniere L, Cottyn B, Bernal E, Jacobs JM, Koebnik R, Osdaghi E, Potnis N, Pothier JF.	Mol Plant Pathol	10.1111/mpp.13185	2022
Pathogenicity	Genomic evidence reveals the extreme diversity and wide distribution of the arsenic-related genes in Burkholderiales.	Li X, Zhang L, Wang G.	PLoS One	10.1371/journal.pone.0092236	2014
Pathogenicity	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.	Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, Zhang LH, Verma C, Tan P.	Antimicrob Agents Chemother	10.1128/aac.02327-12	2013
Metabolism	Regulation and evolution of malonate and propionate catabolism in proteobacteria.	Suvorova IA, Ravcheev DA, Gelfand MS.	J Bacteriol	10.1128/jb.00163-12	2012
	Diagnostically and experimentally useful panel of strains from the Burkholderia cepacia complex.	Mahenthiralingam E, Coenye T, Chung JW, Speert DP, Govan JR, Taylor P, Vandamme P.	J Clin Microbiol	10.1128/jcm.38.2.910-913.2000	2000
Phylogeny	Microbiota analysis optimization for human bronchoalveolar lavage fluid.	Schneeberger PHH, Prescod J, Levy L, Hwang D, Martinu T, Coburn B.	Microbiome	10.1186/s40168-019-0755-x	2019
	Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics.	Meirelles LA, Perry EK, Bergkessel M, Newman DK.	PLoS Biol	10.1371/journal.pbio.3001093	2021
Transcriptome	Comparative transcriptome analysis of a toxin-producing dinoflagellate Alexandrium catenella and its non-toxic mutant.	Zhang Y, Zhang SF, Lin L, Wang DZ.	Mar Drugs	10.3390/md12115698	2014
Metabolism	Complete nucleotide sequence of an exogenously isolated plasmid, pLB1, involved in gamma-hexachlorocyclohexane degradation.	Miyazaki R, Sato Y, Ito M, Ohtsubo Y, Nagata Y, Tsuda M.	Appl Environ Microbiol	10.1128/aem.01531-06	2006
Enzymology	Comparison of DNA extraction methods for microbial community profiling with an application to pediatric bronchoalveolar lavage samples.	Willner D, Daly J, Whiley D, Grimwood K, Wainwright CE, Hugenholtz P.	PLoS One	10.1371/journal.pone.0034605	2012
Phylogeny	DNA-Based diagnostic approaches for identification of Burkholderia cepacia complex, Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III.	Mahenthiralingam E, Bischof J, Byrne SK, Radomski C, Davies JE, Av-Gay Y, Vandamme P.	J Clin Microbiol	10.1128/jcm.38.9.3165-3173.2000	2000
Enzymology	Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates.	Gonyar LA, Fankhauser SC, Goldberg JB.	Environ Microbiol Rep	10.1111/1758-2229.12217	2015
	The promise of bacteriophage therapy for Burkholderia cepacia complex respiratory infections.	Semler DD, Lynch KH, Dennis JJ, Dennis JJ.	Front Cell Infect Microbiol	10.3389/fcimb.2011.00027	2011
Enzymology	A new species of Burkholderia isolated from sugarcane roots promotes plant growth.	Paungfoo-Lonhienne C, Lonhienne TG, Yeoh YK, Webb RI, Lakshmanan P, Chan CX, Lim PE, Ragan MA, Schmidt S, Hugenholtz P.	Microb Biotechnol	10.1111/1751-7915.12105	2014
	TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog.	Zhang Q, Zmasek CM, Cai X, Godzik A.	Dev Comp Immunol	10.1016/j.dci.2010.11.013	2011
Metabolism	Host Range of the Conjugative Transfer System of IncP-9 Naphthalene-Catabolic Plasmid NAH7 and Characterization of Its oriT Region and Relaxase.	Kishida K, Inoue K, Ohtsubo Y, Nagata Y, Tsuda M.	Appl Environ Microbiol	10.1128/aem.02359-16	2017
Genetics	Genome Sequence of the Thermotolerant Foodborne Pathogen Salmonella enterica Serovar Senftenberg ATCC 43845 and Phylogenetic Analysis of Loci Encoding Increased Protein Quality Control Mechanisms.	Nguyen SV, Harhay GP, Bono JL, Smith TP, Harhay DM.	mSystems	10.1128/msystems.00190-16	2017
Metabolism	Structural and functional characterization of diffusible signal factor family quorum-sensing signals produced by members of the Burkholderia cepacia complex.	Deng Y, Wu J, Eberl L, Zhang LH.	Appl Environ Microbiol	10.1128/aem.00480-10	2010
Phylogeny	Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia cepacia complex species: a proof-of-concept study.	Ho CC, Lau CC, Martelli P, Chan SY, Tse CW, Wu AK, Yuen KY, Lau SK, Woo PC.	J Clin Microbiol	10.1128/jcm.01702-10	2011
	Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors.	Bernier SP, Workentine ML, Li X, Magarvey NA, O'Toole GA, Surette MG.	Front Microbiol	10.3389/fmicb.2016.00725	2016
	In silico analysis of human Telomerase Reverse Transcriptase (hTERT) gene: identification of a distant homolog of Melanoma Antigen Family Gene (MAGE).	Amin R, Jesmin, Jamil H, Hossain MA.	Cancer Inform	10.4137/cin.s3392	2009
Phylogeny	Biofilm formation and acyl homoserine lactone production in the Burkholderia cepacia complex.	Conway BA, Venu V, Speert DP.	J Bacteriol	10.1128/jb.184.20.5678-5685.2002	2002
Metabolism	Comparison of the complete genome sequences of four gamma-hexachlorocyclohexane-degrading bacterial strains: insights into the evolution of bacteria able to degrade a recalcitrant man-made pesticide.	Tabata M, Ohhata S, Nikawadori Y, Kishida K, Sato T, Kawasumi T, Kato H, Ohtsubo Y, Tsuda M, Nagata Y.	DNA Res	10.1093/dnares/dsw041	2016
Genetics	The quest for biofuels fuels genome sequencing.	Galperin MY.	Environ Microbiol	10.1111/j.1462-2920.2008.01754.x	2008
	Correlation between an in vitro invasion assay and a murine model of Burkholderia cepacia lung infection.	Cieri MV, Mayer-Hamblett N, Griffith A, Burns JL.	Infect Immun	10.1128/iai.70.3.1081-1086.2002	2002
Metabolism	Catalytic mechanism of short ethoxy chain nonylphenol dehydrogenase belonging to a polyethylene glycol dehydrogenase group in the GMC oxidoreductase family.	Liu X, Ohta T, Kawabata T, Kawai F.	Int J Mol Sci	10.3390/ijms14011218	2013
Pathogenicity	Antibiotic resistance in Burkholderia species.	Rhodes KA, Schweizer HP.	Drug Resist Updat	10.1016/j.drup.2016.07.003	2016
Metabolism	Mycobacterium tuberculosis Rv0899 defines a family of membrane proteins widespread in nitrogen-fixing bacteria.	Marassi FM.	Proteins	10.1002/prot.23151	2011
	Comparative analysis of plant and animal models for characterization of Burkholderia cepacia virulence.	Bernier SP, Silo-Suh L, Woods DE, Ohman DE, Sokol PA.	Infect Immun	10.1128/iai.71.9.5306-5313.2003	2003
Metabolism	Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection.	McClean S, Healy ME, Collins C, Carberry S, O'Shaughnessy L, Dennehy R, Adams A, Kennelly H, Corbett JM, Carty F, Cahill LA, Callaghan M, English K, Mahon BP, Doyle S, Shinoy M.	Infect Immun	10.1128/iai.01248-15	2016
	CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.	Musson JA, Reynolds CJ, Rinchai D, Nithichanon A, Khaenam P, Favry E, Spink N, Chu KK, De Soyza A, Bancroft GJ, Lertmemongkolchai G, Maillere B, Boyton RJ, Altmann DM, Robinson JH.	J Immunol	10.4049/jimmunol.1402273	2014
	Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis.	Nunvar J, Kalferstova L, Bloodworth RA, Kolar M, Degrossi J, Lubovich S, Cardona ST, Drevinek P.	PLoS One	10.1371/journal.pone.0160975	2016
Metabolism	Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.	Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA.	J Bacteriol	10.1128/jb.00431-18	2019
	Identification of quorum sensing-controlled genes in Burkholderia ambifaria.	Chapalain A, Vial L, Laprade N, Dekimpe V, Perreault J, Deziel E.	Microbiologyopen	10.1002/mbo3.67	2013
Phylogeny	PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients.	McDowell A, Mahenthiralingam E, Moore JE, Dunbar KE, Webb AK, Dodd ME, Martin SL, Millar BC, Scott CJ, Crowe M, Elborn JS.	J Clin Microbiol	10.1128/jcm.39.12.4247-4255.2001	2001
	Nasal immunization with Burkholderia multivorans outer membrane proteins and the mucosal adjuvant adamantylamide dipeptide confers efficient protection against experimental lung infections with B. multivorans and B. cenocepacia.	Bertot GM, Restelli MA, Galanternik L, Aranibar Urey RC, Valvano MA, Grinstein S.	Infect Immun	10.1128/iai.01668-06	2007
Metabolism	Pathway and evolutionary implications of diphenylamine biodegradation by Burkholderia sp. strain JS667.	Shin KA, Spain JC.	Appl Environ Microbiol	10.1128/aem.02198-08	2009
Metabolism	Distribution and properties of the genes encoding the biosynthesis of the bacterial cofactor, pyrroloquinoline quinone.	Shen YQ, Bonnot F, Imsand EM, RoseFigura JM, Sjolander K, Klinman JP.	Biochemistry	10.1021/bi201763d	2012
Metabolism	Genomes and characterization of phages Bcep22 and BcepIL02, founders of a novel phage type in Burkholderia cenocepacia.	Gill JJ, Summer EJ, Russell WK, Cologna SM, Carlile TM, Fuller AC, Kitsopoulos K, Mebane LM, Parkinson BN, Sullivan D, Carmody LA, Gonzalez CF, LiPuma JJ, Young R.	J Bacteriol	10.1128/jb.05287-11	2011
Enzymology	Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.	Poirel L, Rodriguez-Martinez JM, Plesiat P, Nordmann P.	Antimicrob Agents Chemother	10.1128/aac.00946-08	2009
	Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements.	Ronning CM, Losada L, Brinkac L, Inman J, Ulrich RL, Schell M, Nierman WC, Deshazer D.	BMC Microbiol	10.1186/1471-2180-10-202	2010
Phylogeny	Development of a species-specific fur gene-based method for identification of the Burkholderia cepacia complex.	Lynch KH, Dennis JJ, Dennis JJ.	J Clin Microbiol	10.1128/jcm.01460-07	2008
Genetics	Genome-Wide Metabolic Reconstruction of the Synthesis of Polyhydroxyalkanoates from Sugars and Fatty Acids by Burkholderia Sensu Lato Species.	Alvarez-Santullano N, Villegas P, Mardones MS, Duran RE, Donoso R, Gonzalez A, Sanhueza C, Navia R, Acevedo F, Perez-Pantoja D, Seeger M.	Microorganisms	10.3390/microorganisms9061290	2021
Metabolism	STING mediates immune responses in the closest living relatives of animals.	Woznica A, Kumar A, Sturge CR, Xing C, King N, Pfeiffer JK.	Elife	10.7554/elife.70436	2021
Genetics	The complete multipartite genome sequence of Cupriavidus necator JMP134, a versatile pollutant degrader.	Lykidis A, Perez-Pantoja D, Ledger T, Mavromatis K, Anderson IJ, Ivanova NN, Hooper SD, Lapidus A, Lucas S, Gonzalez B, Kyrpides NC.	PLoS One	10.1371/journal.pone.0009729	2010
	Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia.	Bernier SP, Sokol PA.	J Bacteriol	10.1128/jb.187.15.5278-5291.2005	2005
Pathogenicity	Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria.	Rushton L, Sass A, Baldwin A, Dowson CG, Donoghue D, Mahenthiralingam E.	Antimicrob Agents Chemother	10.1128/aac.00140-13	2013
Metabolism	Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species.	Van Acker H, Sass A, Bazzini S, De Roy K, Udine C, Messiaen T, Riccardi G, Boon N, Nelis HJ, Mahenthiralingam E, Coenye T.	PLoS One	10.1371/journal.pone.0058943	2013
Genetics	Selection Is a Significant Driver of Gene Gain and Loss in the Pangenome of the Bacterial Genus Sulfurovum in Geographically Distinct Deep-Sea Hydrothermal Vents.	Moulana A, Anderson RE, Fortunato CS, Huber JA.	mSystems	10.1128/msystems.00673-19	2020
Metabolism	Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species.	Butt AT, Thomas MS.	Front Cell Infect Microbiol	10.3389/fcimb.2017.00460	2017
	Molecular signatures and phylogenomic analysis of the genus Burkholderia: proposal for division of this genus into the emended genus Burkholderia containing pathogenic organisms and a new genus Paraburkholderia gen. nov. harboring environmental species.	Sawana A, Adeolu M, Gupta RS.	Front Genet	10.3389/fgene.2014.00429	2014
	In vitro analysis of ISEcp1B-mediated mobilization of naturally occurring beta-lactamase gene blaCTX-M of Kluyvera ascorbata.	Lartigue MF, Poirel L, Aubert D, Nordmann P.	Antimicrob Agents Chemother	10.1128/aac.50.4.1282-1286.2006	2006
Genetics	An evidence of laccases in archaea.	Sharma KK, Kuhad RC.	Indian J Microbiol	10.1007/s12088-009-0039-4	2009
Enzymology	Insights into beta-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.	Papp-Wallace KM, Taracila MA, Gatta JA, Ohuchi N, Bonomo RA, Nukaga M.	J Biol Chem	10.1074/jbc.m113.458315	2013
	Transcriptional response of Burkholderia cenocepacia J2315 sessile cells to treatments with high doses of hydrogen peroxide and sodium hypochlorite.	Peeters E, Sass A, Mahenthiralingam E, Nelis H, Coenye T.	BMC Genomics	10.1186/1471-2164-11-90	2010
Metabolism	Complete nucleotide sequence of TOL plasmid pDK1 provides evidence for evolutionary history of IncP-7 catabolic plasmids.	Yano H, Miyakoshi M, Ohshima K, Tabata M, Nagata Y, Hattori M, Tsuda M.	J Bacteriol	10.1128/jb.00359-10	2010
Metabolism	Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology.	Puchalka J, Oberhardt MA, Godinho M, Bielecka A, Regenhardt D, Timmis KN, Papin JA, Martins dos Santos VA.	PLoS Comput Biol	10.1371/journal.pcbi.1000210	2008
Phylogeny	Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex.	Baldwin A, Mahenthiralingam E, Thickett KM, Honeybourne D, Maiden MC, Govan JR, Speert DP, Lipuma JJ, Vandamme P, Dowson CG.	J Clin Microbiol	10.1128/jcm.43.9.4665-4673.2005	2005
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
	Xenobiotic efflux in bacteria and fungi: a genomics update.	Barabote RD, Thekkiniath J, Strauss RE, Vediyappan G, Fralick JA, San Francisco MJ.	Adv Enzymol Relat Areas Mol Biol	10.1002/9780470920541.ch6	2011
	Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase.	Orville AM, Lountos GT, Finnegan S, Gadda G, Prabhakar R.	Biochemistry	10.1021/bi801918u	2009
Genetics	Genomic characterization of the intron-containing T7-like phage phiL7 of Xanthomonas campestris.	Lee CN, Lin JW, Weng SF, Tseng YH.	Appl Environ Microbiol	10.1128/aem.01214-09	2009
	Population-specific gene expression in the plant pathogenic nematode Heterodera glycines exists prior to infection and during the onset of a resistant or susceptible reaction in the roots of the Glycine max genotype Peking.	Klink VP, Hosseini P, MacDonald MH, Alkharouf NW, Matthews BF.	BMC Genomics	10.1186/1471-2164-10-111	2009
Metabolism	Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases.	Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ.	J Bacteriol	10.1128/jb.01945-07	2008
	Inactivation of Burkholderia cepacia complex phage KS9 gp41 identifies the phage repressor and generates lytic virions.	Lynch KH, Seed KD, Stothard P, Dennis JJ, Dennis JJ.	J Virol	10.1128/jvi.01843-09	2010
	Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa.	Domenech CE, Otero LH, Beassoni PR, Lisa AT.	Enzyme Res	10.4061/2011/561841	2011
Enzymology	An exocellular protein from the oil-degrading microbe Acinetobacter venetianus RAG-1 enhances the emulsifying activity of the polymeric bioemulsifier emulsan.	Bach H, Berdichevsky Y, Gutnick D.	Appl Environ Microbiol	10.1128/aem.69.5.2608-2615.2003	2003
Metabolism	The Vein Patterning 1 (VEP1) gene family laterally spread through an ecological network.	Tarrio R, Ayala FJ, Rodriguez-Trelles F.	PLoS One	10.1371/journal.pone.0022279	2011
Genetics	Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex.	Goudie AD, Lynch KH, Seed KD, Stothard P, Shrivastava S, Wishart DS, Dennis JJ, Dennis JJ.	BMC Genomics	10.1186/1471-2164-9-615	2008
Enzymology	Evolution of bacterial phosphoglycerate mutases: non-homologous isofunctional enzymes undergoing gene losses, gains and lateral transfers.	Foster JM, Davis PJ, Raverdy S, Sibley MH, Raleigh EA, Kumar S, Carlow CK.	PLoS One	10.1371/journal.pone.0013576	2010
Phylogeny	New degenerate Cytophaga-Flexibacter-Bacteroides-specific 16S ribosomal DNA-targeted oligonucleotide probes reveal high bacterial diversity in River Taff epilithon.	O'Sullivan LA, Weightman AJ, Fry JC.	Appl Environ Microbiol	10.1128/aem.68.1.201-210.2002	2002
	Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding L-ornithine N(5)-oxygenase.	Sokol PA, Darling P, Woods DE, Mahenthiralingam E, Kooi C.	Infect Immun	10.1128/iai.67.9.4443-4455.1999	1999
Cultivation	Evaluation of Three Culture Media for Isolation of Burkholderia cepacia Complex from Respiratory Samples of Patients with Cystic Fibrosis.	Marrs ECL, Perry A, Perry JD.	Microorganisms	10.3390/microorganisms9122604	2021
	Effect of beta-Lactamase inhibitors on in vitro activity of beta-Lactam antibiotics against Burkholderia cepacia complex species.	Everaert A, Coenye T.	Antimicrob Resist Infect Control	10.1186/s13756-016-0142-3	2016
Pathogenicity	Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.	Brackman G, Cos P, Maes L, Nelis HJ, Coenye T.	Antimicrob Agents Chemother	10.1128/aac.00045-11	2011
Pathogenicity	Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of Caenorhabditis elegans.	Huber B, Feldmann F, Kothe M, Vandamme P, Wopperer J, Riedel K, Eberl L.	Infect Immun	10.1128/iai.72.12.7220-7230.2004	2004
	The Class A beta-Lactamase Produced by Burkholderia Species Compromises the Potency of Tebipenem against a Panel of Isolates from the United States.	Becka SA, Zeiser ET, LiPuma JJ, Papp-Wallace KM	Antibiotics (Basel)	10.3390/antibiotics11050674	2022
Genetics	A Histone-Like Nucleoid Structuring Protein Regulates Several Virulence Traits in Burkholderia multivorans.	Gomes SC, Ferreira MR, Tavares AF, Silva IN, Becker JD, Moreira LM	Appl Environ Microbiol	10.1128/AEM.00369-21	2021
Metabolism	A transcriptional regulator, IscR, of Burkholderia multivorans acts as both repressor and activator for transcription of iron-sulfur cluster-biosynthetic isc operon.	Nonoyama S, Kishida K, Sakai K, Nagata Y, Ohtsubo Y, Tsuda M	Res Microbiol	10.1016/j.resmic.2020.06.005	2020
Pathogenicity	"Switching Partners": Piperacillin-Avibactam Is a Highly Potent Combination against Multidrug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli Cystic Fibrosis Isolates.	Zeiser ET, Becka SA, Wilson BM, Barnes MD, LiPuma JJ, Papp-Wallace KM	J Clin Microbiol	10.1128/JCM.00181-19	2019
Metabolism	Characterization of the AmpC beta-Lactamase from Burkholderia multivorans.	Becka SA, Zeiser ET, Barnes MD, Taracila MA, Nguyen K, Singh I, Sutton GG, LiPuma JJ, Fouts DE, Papp-Wallace KM	Antimicrob Agents Chemother	10.1128/AAC.01140-18	2018
Metabolism	The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616.	Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M	Appl Environ Microbiol	10.1128/AEM.00479-17	2017
	Identification of Burkholderia multivorans ATCC 17616 genetic determinants for fitness in soil by using signature-tagged mutagenesis.	Nagata Y, Senbongi J, Ishibashi Y, Sudo R, Miyakoshi M, Ohtsubo Y, Tsuda M	Microbiology (Reading)	10.1099/mic.0.077057-0	2014
Pathogenicity	Growth on mannitol-rich media elicits a genome-wide transcriptional response in Burkholderia multivorans that impacts on multiple virulence traits in an exopolysaccharide-independent manner.	Denman CC, Robinson MT, Sass AM, Mahenthiralingam E, Brown AR	Microbiology (Reading)	10.1099/mic.0.072975-0	2013
Pathogenicity	Comparative metabolic systems analysis of pathogenic Burkholderia.	Bartell JA, Yen P, Varga JJ, Goldberg JB, Papin JA	J Bacteriol	10.1128/JB.00997-13	2013
Pathogenicity	Burkholderia multivorans survival and trafficking within macrophages.	Schmerk CL, Valvano MA	J Med Microbiol	10.1099/jmm.0.051243-0	2012
Metabolism	Suppression of pleiotropic phenotypes of a Burkholderia multivorans fur mutant by oxyR mutation.	Kimura A, Yuhara S, Ohtsubo Y, Nagata Y, Tsuda M	Microbiology (Reading)	10.1099/mic.0.057372-0	2012
Metabolism	Pivotal role of anthranilate dioxygenase genes in the adaptation of Burkholderia multivorans ATCC 17616 in soil.	Nishiyama E, Ohtsubo Y, Yamamoto Y, Nagata Y, Tsuda M	FEMS Microbiol Lett	10.1111/j.1574-6968.2012.02532.x	2012
Metabolism	Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.	Malott RJ, Steen-Kinnaird BR, Lee TD, Speert DP	Antimicrob Agents Chemother	10.1128/AAC.00602-11	2011
Genetics	Identification of Burkholderia multivorans ATCC 17616 genes induced in soil environment by in vivo expression technology.	Nishiyama E, Ohtsubo Y, Nagata Y, Tsuda M	Environ Microbiol	10.1111/j.1462-2920.2010.02227.x	2010
Metabolism	Pleiotropic roles of iron-responsive transcriptional regulator Fur in Burkholderia multivorans.	Yuhara S, Komatsu H, Goto H, Ohtsubo Y, Nagata Y, Tsuda M	Microbiology (Reading)	10.1099/mic.0.2007/015537-0	2008
Phylogeny	Organization and localization of the dnaA and dnaK gene regions on the multichromosomal genome of Burkholderia multivorans ATCC 17616.	Nagata Y, Matsuda M, Komatsu H, Imura Y, Sawada H, Ohtsubo Y, Tsuda M	J Biosci Bioeng	10.1263/jbb.99.603	2005
Stress	High-temperature-induced transposition of insertion elements in burkholderia multivorans ATCC 17616.	Ohtsubo Y, Genka H, Komatsu H, Nagata Y, Tsuda M	Appl Environ Microbiol	10.1128/AEM.71.4.1822-1828.2005	2005
Genetics	Distribution and organization of auxotrophic genes on the multichromosomal genome of Burkholderia multivorans ATCC 17616.	Komatsu H, Imura Y, Ohori A, Nagata Y, Tsuda M	J Bacteriol	10.1128/JB.185.11.3333-3343.2003	2003
Genetics	Characterization of N-acyl homoserine lactone overproducing mutants of Burkholderia multivorans ATCC 17616.	Yao F, Zhou H, Lessie TG	FEMS Microbiol Lett	10.1111/j.1574-6968.2002.tb11010.x	2002
Phylogeny	Chryseobacterium aquaticum sp. nov., isolated from a water reservoir.	Kim KK, Lee KC, Oh HM, Lee JS.	Int J Syst Evol Microbiol	10.1099/ijs.0.65491-0	2008

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#53550	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 37245
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Burkholderia multivorans (CCUG 37245, ATCC 17616, LMG 17588)

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