Name: Aggregatibacter aphrophilus CIP 70.73
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 135780

Type strain:

Species: Aggregatibacter aphrophilus

Culture col. no.: CIP 70.73, ATCC 33389, CCUG 3715, NCTC 5906

Strain history: CIP <- 1970, NCTC <- 1939, O. Khairat, London, UK: strain 320, Haemophilus aphrophilus

NCBI tax ID(s): 985008 (strain), 732 (species)

SI-ID 40472

ATCC 33389, NCTC 5906, CCUG 3715, CCM 3581, CIP 70.73, CNCTC 7358, LMG 25821

Other strains from Aggregatibacter aphrophilus

Section

Aggregatibacter aphrophilus CIP 70.73 is a microaerophile, mesophilic, Gram-negative bacterium that was isolated from Blood.

Gram-negative
mesophilic
microaerophile
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Pseudomonadota*
	Class	*Gammaproteobacteria*
	Order	*Pasteurellales*
	Family	*Pasteurellaceae*
	Genus	*Aggregatibacter*
	Species	**Aggregatibacter aphrophilus**
	Full Scientific Name (LPSN)	Aggregatibacter aphrophilus (Khairat 1940) Nørskov-Lauritsen and Kilian 2006

	Synonym	Haemophilus paraphrophilus
	Synonym	Haemophilus aphrophilus

Information on morphological and physiological properties Morphology

[Ref.: #35024]	Gram stain	negative
[Ref.: #69480]	Gram stain	negative Confidence in %99.909

[Ref.: #35024]	Cell shape	oval-shaped

[Ref.: #35024]	Motility	no

[Ref.: #35024]

Hemolysis ability

Information on culture and growth conditions Culture and growth conditions

[Ref.: #35024]

Culture medium

MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria

[Ref.: #35024]

Culture medium growth

[Ref.: #35024]

Culture medium composition

expand / minimize

[Ref.: #35024]

Culture medium

CIP Medium 10

[Ref.: #35024]

Culture medium growth

[Ref.: #35024]

Culture medium link

Medium recipe provided by DSMZ

	Temperatures	Kind of temperature		Temperature
[Ref.: #35024]			growth	37 °C
[Ref.: #44685]			growth	37 °C

[Ref.: #35024]	Temperature range	mesophilic
[Ref.: #44685]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #44685]	Oxygen tolerance	microaerophile
[Ref.: #35024]	Oxygen tolerance	facultative anaerobe

[Ref.: #69481]	Ability of spore formation	no Confidence in %100
[Ref.: #69480]	Ability of spore formation	no Confidence in %99.994

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68381]	alpha-cyclodextrin ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68371]	amygdalin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	arbutin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68381]	arginine ChEBI	-	hydrolysis	* from API rID32STR
[Ref.: #68371]	cellobiose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-arabinose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-arabitol ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	D-fructose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-fucose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-galactose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-glucose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-lyxose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-mannitol ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	D-mannose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-ribose ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	D-sorbitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-tagatose ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	D-xylose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	erythritol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	esculin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	galactitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	gentiobiose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	gluconate ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	glycerol ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	glycogen ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68381]	glycogen ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]	hippurate ChEBI	-	hydrolysis	* from API rID32STR
[Ref.: #68371]	inulin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-arabinose ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	L-arabitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-fucose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-rhamnose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-sorbose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-xylose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	lactose ChEBI	+	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	maltose ChEBI	+	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	melezitose ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	melibiose ChEBI	-	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	methyl alpha-D-glucopyranoside ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	methyl alpha-D-mannoside ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68381]	methyl beta-D-glucopyranoside ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68371]	methyl beta-D-xylopyranoside ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	myo-inositol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	N-acetylglucosamine ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #35024]	nitrate ChEBI	+	reduction
[Ref.: #35024]	nitrite ChEBI	-	reduction
[Ref.: #68371]	Potassium 2-ketogluconate ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	Potassium 5-ketogluconate ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68381]	pullulan ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68371]	raffinose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68381]	raffinose ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68371]	ribitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	salicin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68381]	sorbitol ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68371]	starch ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	sucrose ChEBI	+	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	trehalose ChEBI	+	builds acid from	* from API 50CH acid, API rID32STR
[Ref.: #68371]	turanose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68381]	urea ChEBI	-	hydrolysis	* from API rID32STR
[Ref.: #68371]	xylitol ChEBI	-	builds acid from	* from API 50CH acid
	Only first 10 entries are displayed. Click here to see all.

	Antibiotica	Metabolite	Antibiotic sensitivity	Antibiotic resistance
[Ref.: #35024]		0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)	yes	no

	Metabolite production	Metabolite	Production
[Ref.: #35024]		indole ChEBI	no
[Ref.: #68381]		acetoin ChEBI	no	* from API rID32STR

	Physiological tests	Metabolite	Voges-Proskauer-test
[Ref.: #68381]		acetoin ChEBI	-	* from API rID32STR

	Enzyme	Enzyme activity	EC number
[Ref.: #68381]	Alanyl-Phenylalanyl-Proline arylamidase	-		* from API rID32STR
[Ref.: #35024]	alcohol dehydrogenase	-	1.1.1.1
[Ref.: #68381]	alkaline phosphatase	+	3.1.3.1	* from API rID32STR
[Ref.: #68381]	alpha-galactosidase	-	3.2.1.22	* from API rID32STR
[Ref.: #68381]	arginine dihydrolase	-	3.5.3.6	* from API rID32STR
[Ref.: #35024]	beta-galactosidase	+	3.2.1.23
[Ref.: #68381]	beta-galactosidase	+	3.2.1.23	* from API rID32STR
[Ref.: #68381]	beta-glucosidase	-	3.2.1.21	* from API rID32STR
[Ref.: #68381]	beta-glucuronidase	-	3.2.1.31	* from API rID32STR
[Ref.: #68381]	beta-mannosidase	-	3.2.1.25	* from API rID32STR
[Ref.: #35024]	catalase	-	1.11.1.6
[Ref.: #68381]	glycyl tryptophan arylamidase	-		* from API rID32STR
[Ref.: #35024]	lysine decarboxylase	-	4.1.1.18
[Ref.: #68381]	N-acetyl-beta-glucosaminidase	-	3.2.1.52	* from API rID32STR
[Ref.: #35024]	ornithine decarboxylase	-	4.1.1.17
[Ref.: #35024]	oxidase	-
[Ref.: #68381]	pyrrolidonyl arylamidase	-	3.4.19.3	* from API rID32STR
[Ref.: #35024]	urease	-	3.5.1.5
[Ref.: #68381]	urease	-	3.5.1.5	* from API rID32STR
	Only first 10 entries are displayed. Click here to see all.

API® 50CH acid:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	ControlQ	Acid from glycerolGLY	Acid from erythritolERY	Acid from D-arabinoseDARA	Acid from L-arabinoseLARA	Acid from D-riboseRIB	Acid from D-xyloseDXYL	Acid from L-xyloseLXYL	Acid from D-adonitolADO	Acid from methyl beta-D-xylopyranosideMDX	Acid from D-galactoseGAL	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from D-mannoseMNE	Acid from L-sorboseSBE	Acid from L-rhamnoseRHA	Acid from dulcitolDUL	Acid from inositolINO	Acid from D-mannitolMAN	Acid from D-sorbitolSOR	Acid from methyl alpha-D-mannopyranosideMDM	Acid from methyl alpha-D-glucopyranosideMDG	Acid from N-acetyl-glucosamineNAG	Acid from amygdalinAMY	Acid from arbutinARB	Acid from esculinESC	Acid from salicinSAL	Acid from cellobioseCEL	Acid from maltoseMAL	Acid from lactoseLAC	Acid from melibioseMEL	Acid from sucroseSAC	Acid from trehaloseTRE	Acid from inulinINU	Acid from melezitoseMLZ	Acid from raffinoseRAF	Acid from starchAMD	Acid from glycogenGLYG	Acid from xylitolXLT	Acid from gentiobioseGEN	Acid from turanoseTUR	Acid from D-lyxoseLYX	Acid from D-tagatoseTAG	Acid from D-fucoseDFUC	Acid from L-fucoseLFUC	Acid from D-arabitolDARL	Acid from L-arabitolLARL	Acid from gluconateGNT	Acid from 2-Ketogluconate2KG	Acid from 5-Ketogluconate5KG
[Ref.: #35024]	12094	not determinedn.d.	+	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	+	+	-	+	+	-	-	+	+	+	-	-	+	-	-	-	-	-	-	+	-	+

API® rID32STR:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Arginine dihydrolaseADH (Arg)	beta-Glucosidasebeta GLU	beta-Galactosidasebeta GAR	beta-Glucuronidasebeta GUR	alpha-Galactosidasealpha GAL	Alkaline PhosphatasePAL	Acid from D-riboseRIB	Acid from D-mannitolMAN	Acid from sorbitolSOR	Acid from lactoseLAC	Acid from trehaloseTRE	Acid from raffinoseRAF	Acid from sucroseSAC	Acid from L-arabinoseLARA	Acid from D-arabitolDARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta-Galactosidasebeta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	Hydrolysis of hippuric acidHIP	Acid from glycogenGLYG	Acid from pullulanPUL	Acid from maltoseMAL	Acid from melibioseMEL	Acid from melezitoseMLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	Acid from D-tagatoseTAG	beta-Mannosidasebeta MAN	Urease/urea hydrolysisURE
[Ref.: #44685]	4166	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	-	+	-	-	-	-	-	-	+	-	-	-	-	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #35024]	Sample type/isolated from	Blood
[Ref.: #35024]	Isolation date	1939
* marker position based on {}

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #35024]

Biosafety level

Risk group (French classification)

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Aggregatibacter aphrophilus ATCC 33389 NCTC 5906	GCA_900636915	complete	GenBank	985008 tax ID	*
[Ref.: #66792]	Aggregatibacter aphrophilus ATCC 33389	GCA_000226495	contig	GenBank	985008 tax ID	*
[Ref.: #66792]	Aggregatibacter aphrophilus ATCC 33389	985008.3	wgs	PATRIC	985008 tax ID	*
[Ref.: #66792]	Aggregatibacter aphrophilus ATCC 33389 strain NCTC5906 strain NCTC 5906	985008.4	complete	PATRIC	985008 tax ID	*
[Ref.: #66792]	Aggregatibacter aphrophilus ATCC 33389 NCTC 5906	2841352428	complete	JGI IMG/M	985008 tax ID	*
[Ref.: #66792]	Aggregatibacter aphrophilus 320, ATCC 33389	2537561844	draft	JGI IMG/M	985008 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Aggregatibacter aphrophilus ATCC 33389 NCTC5906 NCBI: GCA_900636915.1
[Ref.: #69481]	spore-forming	no	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Aggregatibacter aphrophilus ATCC 33389 NCTC5906 NCBI: GCA_900636915.1
[Ref.: #69480]	flagellated	no	95.083	no
[Ref.: #69480]	gram-positive	no	98.45	no
[Ref.: #69480]	anaerobic	no	95.441	yes
[Ref.: #69480]	aerobic	no	94.334	yes
[Ref.: #69480]	halophile	no	56.368	no
[Ref.: #69480]	spore-forming	no	98.472	no
[Ref.: #69480]	thermophile	no	96.502	yes
[Ref.: #69480]	glucose-util	yes	53.84	no
[Ref.: #69480]	motile	no	89.209	no
[Ref.: #69480]	glucose-ferment	yes	58.324	no

Availability in culture collections External links

[Ref.: #35024]

Culture collection no.

CIP 70.73, ATCC 33389, CCUG 3715, NCTC 5906

[Ref.: #93069]

SI-ID 40472

Literature:

Topic	Title	Authors	Journal	DOI	Year
Phylogeny	Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates.	Norskov-Lauritsen N, Kilian M	Int J Syst Evol Microbiol	10.1099/ijs.0.64207-0	2006	*
Phylogeny	Differentiation among closely related organisms of the Actinobacillus-Haemophilus-Pasteurella group by means of lysozyme and EDTA.	Olsen I, Brondz I	J Clin Microbiol	10.1128/jcm.22.4.629-636.1985	1985	*
Pathogenicity	Use of a nonradioactive genetic probe identified, synthesized, and labeled in the polymerase chain reaction.	Preus HR, Russell DT	Scand J Dent Res	10.1111/j.1600-0722.1994.tb01173.x	1994	*

References

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#35024 Collection of Institut Pasteur ; Curators of the CIP; CIP 70.73
#44685 Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 3715

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68371

Automatically annotated from API 50CH acid .

#68381

Automatically annotated from API rID32STR .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#93069

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID40472.1 )

* These data were automatically processed and therefore are not curated

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Aggregatibacter aphrophilus ATCC 33389 NCTC5906

Aggregatibacter aphrophilus ATCC 33389 NCTC5906

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