Cutibacterium acnes (DSM 16379, KPA 171202)

Name: Cutibacterium acnes (DSM 16379, KPA 171202)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 12637

Type strain

Culture col. no. DSM 16379 KPA 171202

NCBI tax ID(s) 1747

Special Collections DSMZ

Links

Cutibacterium acnes DSM 16379 is an anaerobe, mesophilic prokaryote that was isolated from contamination of an anaerobic culture.

anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 215483

DSM 16379

@ref 20215

Last LPSN update 2025-12-16 09:49:54

Domain Bacillati

Phylum Actinomycetota

Class Actinomycetes

Order Propionibacteriales

Family Propionibacteriaceae

Genus Cutibacterium

Species Cutibacterium acnes

Full scientific name Cutibacterium acnes (Gilchrist 1900) Scholz and Kilian 2016

Synonyms (2)

Propionibacterium acnes
"Bacillus acnes"

BacDive ID	Other strains from **Cutibacterium acnes** (83)	Type strain
12638	C. acnes FR1-165P, DSM 30738
12639	C. acnes FR2-MS23, DSM 30753
12640	C. acnes K2-18, DSM 30919
100658	C. acnes STI07542(IMET), IMET 7542
100659	C. acnes STI07254(IMET), BU57.1,
100660	C. acnes STI07552(IMET), IMET 7552
134424	C. acnes CIP 110517
134720	C. acnes CIP 110513
135376	C. acnes CIP 110518
135568	C. acnes CIP 110526
135569	C. acnes CIP 110527
137097	C. acnes CIP 110506
137098	C. acnes CIP 110509
137399	C. acnes CIP 110530
137400	C. acnes CIP 110531
138963	C. acnes CIP 110525
139597	C. acnes CIP 110519
139636	C. acnes CIP 53.119
139637	C. acnes CIP 54.158
139638	C. acnes CIP 54.166
139639	C. acnes CIP 60.42
139640	C. acnes CIP A179
139641	C. acnes CIP 110371
139642	C. acnes CIP 110503
139643	C. acnes CIP 110504
139644	C. acnes CIP 110505
139645	C. acnes CIP 110510
139646	C. acnes CIP 110511
139647	C. acnes CIP 110512
139648	C. acnes CIP 110514
139649	C. acnes CIP 110515
139650	C. acnes CIP 110516
139651	C. acnes CIP 110520
139652	C. acnes CIP 110521
139653	C. acnes CIP 110523
139654	C. acnes CIP 110529
139655	C. acnes CIP 110533
141766	C. acnes CCUG 6528
141767	C. acnes CCUG 6529
142058	C. acnes CCUG 10171
147123	C. acnes CCUG 32901, LMG 16730
147248	C. acnes CCUG 33192
147253	C. acnes CCUG 33206
147648	C. acnes CCUG 33950
147650	C. acnes CCUG 33951 B
148159	C. acnes CCUG 34938
148493	C. acnes CCUG 35547
148635	C. acnes CCUG 35749
148753	C. acnes CCUG 35900
148938	C. acnes CCUG 36609
148971	C. acnes CCUG 36661
149168	C. acnes CCUG 36986
149215	C. acnes CCUG 37286 B
149692	C. acnes CCUG 38203
149733	C. acnes CCUG 38293
149807	C. acnes CCUG 38453
149870	C. acnes CCUG 38584, ATCC 6922, NCTC 556
151988	C. acnes CCUG 45436
152217	C. acnes CCUG 46136
152639	C. acnes CCUG 47251
152733	C. acnes CCUG 47502
152961	C. acnes CCUG 48138
153010	C. acnes CCUG 48264
153042	C. acnes CCUG 48370
153284	C. acnes CCUG 48996
153647	C. acnes CCUG 50480
153689	C. acnes CCUG 50655
153755	C. acnes CCUG 50865
153995	C. acnes CCUG 51883
154183	C. acnes CCUG 52676
154207	C. acnes CCUG 52753
154208	C. acnes CCUG 52754
154231	C. acnes CCUG 52854
154930	C. acnes CCUG 55746
155481	C. acnes CCUG 57837
157794	C. acnes Z140, DSM 108415
170961	C. acnes CIMB 05-1526, CRBIP17.133
170962	C. acnes CIP 110507
170963	C. acnes CIP 110508
170964	C. acnes CIP 110522
170965	C. acnes CIP 110528
174546	C. acnes AP1, DSM 117891
176486	C. acnes CA02, DSM 117854

Morphology

Cell morphology

@ref	Confidence	Gram stain
125438	94
125439	95.9	positive
125439	91.1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
6416	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)		Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
6416	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)		Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
6416	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

6416

Oxygen toleranceanaerobe

Spore formation

@ref	Spore formation	Confidence
125439		96

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68380	17632 ChEBI	nitrate	+	reduction	from API rID32A
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68380	alpha-galactosidase	-	3.2.1.22	from API rID32A
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	+	3.4.11.5	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
6416	-	-	-	+/-	-	+	-	-	-	+	+	-	-	-	+	+	-	+/-	+	-	-	-	+/-	-	+	+	-	-	+
6416	-	+	-	+/-	-	+	-	-	-	+/-	+	-	-	-	+	+	-	-	+	-	-	-	-	-	+	+	-	-	+
6416	-	+	-	-	-	+	-	-	-	+	+	-	-	-	+	+	-	-	+	-	-	-	-	-	+	+	-	-	+
6416	-	+	-	+	-	+	-	-	-	+	+	-	-	-	+	+/-	-	+	+	-	-	-	-	-	+	+	-	-	+
6416	-	+	-	+	-	+	-	-	+/-	+/-	-	-	-	-	+	-	-	+	+	+/-	-	-	-	-	+	+	-	-	+
6416	-	-	-	+/-	-	+	-	-	+	+	+	-	-	-	+	-	-	+/-	+	-	-	-	-	-	+/-	+/-	-	-	+/-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Contamination	-
#Engineered	#Laboratory	#Lab enrichment
#Condition	#Anoxic (anaerobic)	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent	Latitude	Longitude
6416	contamination of an anaerobic culture	Ulm	Germany	DEU	Europe	48.4011	9.9876 48.4011/9.9876

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
6416	2	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM413621v1 assembly for Cutibacterium acnes KPA171202	complete	GCA_004136215	267747.46	8003656449	267747	98.66

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Propionibacterium acnes 16S ribosomal RNA gene, partial sequence.	KF906603	1486		1747

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Cutibacterium acnes KPA171202
PATRIC: 267747.46

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	96.00	no
125439	motility	BacteriaNetⓘ	no	91.10	no
125439	gram_stain	BacteriaNetⓘ	positive	95.90	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	80.90	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Cutibacterium acnes KPA171202
PATRIC: 267747.46

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.60	no
125438	anaerobic	anaerobicⓘ	no	63.23	yes
125438	spore-forming	spore-formingⓘ	no	78.98	no
125438	aerobic	aerobicⓘ	no	68.81	yes
125438	thermophilic	thermophileⓘ	no	93.98	yes
125438	flagellated	motile2+ⓘ	no	94.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	The Role of Cutibacterium acnes in the Etiopathogenesis of Sarcoidosis: Current Insights and Future Study Directions.	Di Francesco AM, Pasciuto G, Verrecchia E, Sicignano LL, Gerardino L, Rigante D, Manna R.	Int J Mol Sci	10.3390/ijms26146652	2025
	Comprehensive lipidomic analysis of the genus Cutibacterium.	Chudzik A, Bromke MA, Gamian A, Pasciak M.	mSphere	10.1128/msphere.00054-24	2024
	Different Cutibacterium acnes Phylotypes Release Distinct Extracellular Vesicles.	Chudzik A, Migdal P, Pasciak M.	Int J Mol Sci	10.3390/ijms23105797	2022
	Identification and Characterization of Corynaridin, a Novel Linaridin from Corynebacterium lactis.	Pashou E, Reich SJ, Reiter A, Weixler D, Eikmanns BJ, Oldiges M, Riedel CU, Goldbeck O.	Microbiol Spectr	10.1128/spectrum.01756-22	2023
	Establishing a Cell-Free Transcription-Translation Platform for Cutibacterium acnes to Prototype Engineered Metabolic and Synthetic Biology.	Fabrega MJ, Knodlseder N, Nevot G, Sanvicente M, Toloza L, Santos-Moreno J, Guell M.	ACS Biomater Sci Eng	10.1021/acsbiomaterials.1c00894	2023
Pathogenicity	Acne and Stress: Impact of Catecholamines on Cutibacterium acnes.	Borrel V, Thomas P, Catovic C, Racine PJ, Konto-Ghiorghi Y, Lefeuvre L, Duclairoir-Poc C, Zouboulis CC, Feuilloley MGJ.	Front Med (Lausanne)	10.3389/fmed.2019.00155	2019
	Bacteria Modify Their Sensitivity to Chemerin-Derived Peptides by Hindering Peptide Association With the Cell Surface and Peptide Oxidation.	Godlewska U, Bilska B, Majewski P, Pyza E, Zabel BA, Cichy J.	Front Microbiol	10.3389/fmicb.2020.01819	2020
Genetics	Red-Brown Pigmentation of Acidipropionibacterium jensenii Is Tied to Haemolytic Activity and cyl-Like Gene Cluster.	Deptula P, Loivamaa I, Smolander OP, Laine P, Roberts RJ, Piironen V, Paulin L, Savijoki K, Auvinen P, Varmanen P.	Microorganisms	10.3390/microorganisms7110512	2019
	Detailed protocol for germ-free Drosophila melanogaster colonization with Propionibacterium spp. biofilms.	Bronnec V, Alexeyev OA.	STAR Protoc	10.1016/j.xpro.2022.101342	2022
	STITCH and Molecular Docking Analysis of Selected Wood Apple (Limonia acidissima) Constituents as Anti-Dandruff and Anti-Acne Agents.	Vishnupriya N, Sankar MM, Vimal S, Radhakrishnan N.	J Pharm Bioallied Sci	10.4103/jpbs.jpbs_508_23	2024
Pathogenicity	Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting.	Knodlseder N, Nevot G, Fabrega MJ, Mir-Pedrol J, Sanvicente-Garcia M, Campama-Sanz N, Paetzold B, Lood R, Guell M	PLoS Pathog	10.1371/journal.ppat.1010420	2022
Genetics	In vitro emergence of fluoroquinolone resistance in Cutibacterium (formerly Propionibacterium) acnes and molecular characterization of mutations in the gyrA gene.	Takoudju EM, Guillouzouic A, Kambarev S, Pecorari F, Corvec S	Anaerobe	10.1016/j.anaerobe.2017.06.005	2017
	In silico prediction and qPCR validation of novel sRNAs in Propionibacterium acnes KPA171202.	Balgir PP, Dhiman SR, Kaur P	J Genet Eng Biotechnol	10.1016/j.jgeb.2016.03.002	2016
Genetics	Analysis of complete genomes of Propionibacterium acnes reveals a novel plasmid and increased pseudogenes in an acne associated strain.	Kasimatis G, Fitz-Gibbon S, Tomida S, Wong M, Li H	Biomed Res Int	10.1155/2013/918320	2013
Genetics	Comparative genomics and transcriptomics of Propionibacterium acnes.	Brzuszkiewicz E, Weiner J, Wollherr A, Thurmer A, Hupeden J, Lomholt HB, Kilian M, Gottschalk G, Daniel R, Mollenkopf HJ, Meyer TF, Bruggemann H	PLoS One	10.1371/journal.pone.0021581	2011
Enzymology	Expression, purification, crystallization and preliminary X-ray diffraction analysis of the soluble domain of PPA0092, a putative nitrite reductase from Propionibacterium acnes.	Nojiri M, Shirota F, Hira D, Suzuki S	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/S1744309108040207	2009
Genetics	Complete Genome Sequences and Methylome Analyses of Cutibacterium acnes subsp. acnes Strains DSM 16379 and DSM 1897(T).	Deptula P, Laine P, Paulin L, Auvinen P, Roberts RJ, Johnston CD, Varmanen P	Microbiol Resour Announc	10.1128/MRA.00705-20	2020
Enzymology	Characterization of beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Propionibacterium acnes.	Nakajima M, Nishimoto M, Kitaoka M	Appl Microbiol Biotechnol	10.1007/s00253-008-1838-y	2009
Phylogeny	A new phylogenetic group of Propionibacterium acnes.	McDowell A, Perry AL, Lambert PA, Patrick S	J Med Microbiol	10.1099/jmm.0.47489-0	2008

References

#6416	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 16379
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68380	Automatically annotated from API rID32A .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Cutibacterium acnes (DSM 16379, KPA 171202)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Enzymes

API rID32A

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_004136215

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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