Haemophilus haemoglobinophilus (DSM 21241, ATCC 19416, CCUG 3714)

Name: Haemophilus haemoglobinophilus (DSM 21241, ATCC 19416, CCUG 3714)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 11712

Type strain

Strain Designation 375, XII

Culture col. no. DSM 21241 ATCC 19416 CCUG 3714 CIP 53.88 NCTC 1659 2 more

NCBI tax ID(s) 733

Special Collections DSMZ CCUG CIP

History <- CIP CIP <- 1953, NCTC, Haemophilus canis <- 1923, P. Fildes, London, UK <- 1922, M. Kristensen, Copenhagen, Denmark <- E. Friedberger: strain XII <- H.K. Killian: strain 375

Links

Haemophilus haemoglobinophilus 375 is a microaerophile, mesophilic prokaryote that was isolated from dog, prepuce.

microaerophile mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 389262

ATCC 19416,NCTC 1659,CCUG 3714,CIP 53.88,CNCTC 5400,DSM 21241

@ref 20215

Last LPSN update 2026-02-09 11:20:38

Domain Bacteria

Phylum Pseudomonadota

Class Gammaproteobacteria

Order Pasteurellales

Family Pasteurellaceae

Genus Haemophilus

Species Haemophilus haemoglobinophilus

Full scientific name Haemophilus haemoglobinophilus (Lehmann and Neumann 1907) Murray 1939 (Approved Lists 1980)

Synonyms (2)

"Bacterium haemoglobinophilus"
Canicola haemoglobinophilus

BacDive ID	Other strains from **Haemophilus haemoglobinophilus** (1)	Type strain
143683	H. haemoglobinophilus CCUG 20967

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	99.3
125438		94.863
125438	negative	97.603

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
15589	CHOCOLATE AGAR (DSMZ Medium 429b)	Medium recipe at MediaDive	Name: CHOCOLATE AGAR (DSMZ Medium 429b) Composition: Horse blood 100.0 g/l Sheep blood 100.0 g/l Columbia agar base
37738	MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and Neisseria		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml);PolyVitex mischung (10.000 ml)
119763	CIP Medium 10	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
15589	positive	growth	37	mesophilic
37738	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
15589	microaerophile
125439	obligate aerobe	93.4

Spore formation

@ref	Spore formation	Confidence
125439		99.6
125438		93.457

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68377	17634 ChEBI	D-glucose	+	builds acid from	from API NH
68377	18257 ChEBI	ornithine	-	degradation	from API NH
68377	16199 ChEBI	urea	-	hydrolysis	from API NH

Enzymes

@ref	Value	Activity	Ec
68377	alkaline phosphatase	-	3.1.3.1	from API NH
68377	beta-galactosidase	-	3.2.1.23	from API NH
68377	lipase	-		from API NH
68377	ornithine decarboxylase	-	4.1.1.17	from API NH
68377	proline-arylamidase	-	3.4.11.5	from API NH
68377	urease	-	3.5.1.5	from API NH

API NH

@ref	PEN	GLU	FRU	MAL	SAC	ODC	URE	LIP	PAL	beta GAL	ProA	GGT	IND
15589	+	+	-	+	-	-	-	-	-	-	-	+	-
15589	-	+	+	-	+	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Canidae (Dog)
#Host Body-Site	#Urogenital tract	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
15589	dog, prepuce		Denmark	DNK	Europe
44684	Dog prepuce	Copenhagen ?	Denmark	DNK	Europe
119763	Animal, Dog, prepuce

Taxonmaps

69479

Global distribution of 16S sequence M75064 (>99% sequence identity) for Haemophilus haemoglobinophilus subclade from Microbeatlas

Aquatic Samples	47
Soil Samples	9
Animal Samples	785
Plant Samples	5
Total Samples	846

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
15589	2	Risk group (German classification) According to TRBA 466
119763	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	49595_B01 assembly for Canicola haemoglobinophilus NCTC1659	contig	GCA_900450725	733.4	2906570301	733	78.01
66792	ASM201507v1 assembly for Canicola haemoglobinophilus CCUG 3714	scaffold	GCA_002015075	733.3	2916265895	733	60.61

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Haemophilus haemoglobinophilus strain NCTC 1659 16S ribosomal RNA gene, partial sequence	M75064	1476		733
15589	Canicola haemoglobinophilus strain CCUG 3714 16S ribosomal RNA gene, partial sequence	AY362907	1360		733

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Canicola haemoglobinophilus CCUG 3714
NCBI: GCA_002015075

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	99.60	no
125439	motility	BacteriaNetⓘ	no	62.70	no
125439	gram_stain	BacteriaNetⓘ	negative	99.30	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	93.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Canicola haemoglobinophilus CCUG 3714
NCBI: GCA_002015075.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	97.60	no
125438	anaerobic	anaerobicⓘ	no	94.23	yes
125438	aerobic	aerobicⓘ	no	78.92	no
125438	spore-forming	spore-formingⓘ	no	93.46	no
125438	thermophilic	thermophileⓘ	no	99.00	no
125438	flagellated	motile2+ⓘ	no	94.86	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	The effect of the oral administration of lactic-acid probiotic bacteria on the vaginal microflora of bitches.	Andrzej Socha P, Zdunczyk S.	J Vet Res	10.2478/jvetres-2025-0041	2025
	Double semen collection at a 1-h interval in dogs decreases the bacterial contamination of canine ejaculates.	Lechner D, Aurich J, Spergser J, Aurich C.	Theriogenology	10.1016/j.theriogenology.2023.06.002	2023
	The Cultivable Bacteria Colonizing Canine Vagina During Proestrus and Estrus: A Large-Scale Retrospective Study of Influencing Factors.	Schafer-Somi S, Lechner D, Tichy A, Spergser J.	Animals (Basel)	10.3390/ani14233460	2024
	The Impact of a Multi-Strain Probiotic Supplementation on Puppies Manifesting Diarrhoeic Symptoms During the Initial Seven Days of Life.	Socha PA, Socha BM.	Animals (Basel)	10.3390/ani15121700	2025
	The Impact of Microorganisms on Canine Semen Quality.	Domrazek K, Konieczny P, Majka M, Czopowicz M, Jurka P.	Animals (Basel)	10.3390/ani14091267	2024
	Composition of the fecal, vaginal and colostrum microbiotas of dams at parturition and their relationship with neonatal outcomes in dogs.	Garrigues Q, Apper E, Mercier F, Rodiles A, Rovere N, Chastant S, Mila H.	Anim Microbiome	10.1186/s42523-025-00384-1	2025
Phylogeny	Reclassification of [Haemophilus] haemoglobinophilus as Canicola haemoglobinophilus gen. nov., comb. nov. including Bisgaard taxon 35.	Christensen H, Kuhnert P, Foster G, Bisgaard M	Int J Syst Evol Microbiol	10.1099/ijsem.0.004881	2021

References

#15589	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 21241
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#37738	; Curators of the CIP;
#44684	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 3714
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68377	Automatically annotated from API NH .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#119763	Collection of Institut Pasteur ; Curators of the CIP; CIP 53.88
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Haemophilus haemoglobinophilus (DSM 21241, ATCC 19416, CCUG 3714)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Enzymes

API NH

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900450725

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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