Lentilactobacillus senioris (DSM 24302, JCM 17472, YIT 12364)

Name: Lentilactobacillus senioris (DSM 24302, JCM 17472, YIT 12364)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6702

Type strain

Culture col. no. DSM 24302 JCM 17472 YIT 12364

NCBI tax ID(s) 931534

Special Collections DSMZ JCM Literature strains

History <- K. Oki, Yakult Central Inst. Microbiol. Res., Kunitachi, Japan; YIT 12364 <- K. Watanabe K. Oki YIT 12364.

Links

Lentilactobacillus senioris DSM 24302 is a microaerophile, mesophilic, Gram-positive prokaryote that was isolated from feces of a healthy 100-year-old Japanese female.

Gram-positive rod-shaped microaerophile mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 405210

JCM 17472,DSM 24302

@ref 20215

Last LPSN update 2026-02-09 11:19:17

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lentilactobacillus

Species Lentilactobacillus senioris

Full scientific name Lentilactobacillus senioris (Oki et al. 2012) Zheng et al. 2020

Synonyms (1)

Lactobacillus senioris

Morphology

Cell morphology

@ref	Gram stain	Cell length	Cell width	Cell shape	Confidence
30248	positive	01-10 µm	0.7 µm	rod-shaped
125438					90.5
125438	positive				93.683

Pigmentation

30248

Productionyes

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
17627	MRS MEDIUM (DSMZ Medium 11)		Medium recipe at MediaDive	Name: MRS MEDIUM (DSMZ Medium 11) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
17627	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
17627	microaerophile
30248	facultative anaerobe
125439	obligate aerobe	99.5

Spore formation

@ref	Spore formation	Confidence
30248
125438		91.953

Murein

@ref	Murein short key	Type
17627	A11.31	A4alpha L-Lys-D-Asp

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	+	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	+	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
30248	28757 ChEBI	fructose	+	carbon source
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
30248	24265 ChEBI	gluconate	+	carbon source
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	+	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
30248	506227 ChEBI	N-acetylglucosamine	+	carbon source
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	teichoic acid biosynthesis	100	1 of 1
66794	acetate fermentation	100	4 of 4
66794	ppGpp biosynthesis	100	4 of 4
66794	folate polyglutamylation	100	1 of 1
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	coenzyme A metabolism	100	4 of 4
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	vitamin B1 metabolism	84.62	11 of 13
66794	palmitate biosynthesis	81.82	18 of 22
66794	glycogen metabolism	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	ketogluconate metabolism	75	6 of 8
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	flavin biosynthesis	73.33	11 of 15
66794	cardiolipin biosynthesis	71.43	5 of 7
66794	photosynthesis	71.43	10 of 14
66794	degradation of sugar alcohols	68.75	11 of 16
66794	valine metabolism	66.67	6 of 9
66794	acetoin degradation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	formaldehyde oxidation	66.67	2 of 3
66794	glycolysis	64.71	11 of 17
66794	d-xylose degradation	63.64	7 of 11
66794	pentose phosphate pathway	63.64	7 of 11
66794	pyrimidine metabolism	62.22	28 of 45
66794	propanol degradation	57.14	4 of 7
66794	purine metabolism	56.38	53 of 94
66794	serine metabolism	55.56	5 of 9
66794	alanine metabolism	55.17	16 of 29
66794	phenylalanine metabolism	53.85	7 of 13
66794	ethanol fermentation	50	1 of 2
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	sulfopterin metabolism	50	2 of 4
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	phenylmercury acetate degradation	50	1 of 2
66794	gluconeogenesis	50	4 of 8
66794	adipate degradation	50	1 of 2
66794	degradation of pentoses	50	14 of 28
66794	non-pathway related	47.37	18 of 38
66794	oxidative phosphorylation	47.25	43 of 91
66794	d-mannose degradation	44.44	4 of 9
66794	reductive acetyl coenzyme A pathway	42.86	3 of 7
66794	glutamate and glutamine metabolism	42.86	12 of 28
66794	tetrahydrofolate metabolism	42.86	6 of 14
66794	mevalonate metabolism	42.86	3 of 7
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	arachidonate biosynthesis	40	2 of 5
66794	metabolism of amino sugars and derivatives	40	2 of 5
66794	threonine metabolism	40	4 of 10
66794	lipoate biosynthesis	40	2 of 5
66794	Entner Doudoroff pathway	40	4 of 10
66794	lipid metabolism	38.71	12 of 31
66794	urea cycle	38.46	5 of 13
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	37.5	3 of 8
66794	isoleucine metabolism	37.5	3 of 8
66794	cyanate degradation	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	octane oxidation	33.33	1 of 3
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	glycolate and glyoxylate degradation	33.33	2 of 6
66794	sphingosine metabolism	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	methionine metabolism	30.77	8 of 26
66794	leucine metabolism	30.77	4 of 13
66794	starch degradation	30	3 of 10
66794	glycine metabolism	30	3 of 10
66794	arginine metabolism	29.17	7 of 24
66794	ubiquinone biosynthesis	28.57	2 of 7
66794	tyrosine metabolism	28.57	4 of 14
66794	degradation of hexoses	27.78	5 of 18
66794	histidine metabolism	27.59	8 of 29
66794	metabolism of disaccharids	27.27	3 of 11
66794	proline metabolism	27.27	3 of 11
66794	vitamin B6 metabolism	27.27	3 of 11
66794	isoprenoid biosynthesis	26.92	7 of 26
66794	carnitine metabolism	25	2 of 8
66794	glycogen biosynthesis	25	1 of 4
66794	lactate fermentation	25	1 of 4
66794	butanoate fermentation	25	1 of 4
66794	CMP-KDO biosynthesis	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	tryptophan metabolism	23.68	9 of 38
66794	ascorbate metabolism	22.73	5 of 22
66794	nitrate assimilation	22.22	2 of 9
66794	cysteine metabolism	22.22	4 of 18
66794	CO2 fixation in Crenarchaeota	22.22	2 of 9
66794	lipid A biosynthesis	22.22	2 of 9
66794	chorismate metabolism	22.22	2 of 9
66794	glutathione metabolism	21.43	3 of 14
66794	lysine metabolism	21.43	9 of 42

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
17627	-	-	-	-	+	+	+	-	-	-	-	+	+	+/-	-	-	-	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+/-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Patient	-
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)
#Host	#Human	#Female

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
17627	feces of a healthy 100-year-old Japanese female	Okinawa	Japan	JPN	Asia
67770	Feces of a 100-year-old Japanese

Taxonmaps

69479

Global distribution of 16S sequence LC519995 (>99% sequence identity) for Lentilactobacillus senioris subclade from Microbeatlas

Aquatic Samples	115
Soil Samples	17
Animal Samples	717
Plant Samples	55
Total Samples	904

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
17627	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM143655v1 assembly for Lentilactobacillus senioris DSM 24302 = JCM 17472	scaffold	GCA_001436555	1423802.4	2660237942	1423802	75.62
67770	ASM131206v1 assembly for Lentilactobacillus senioris DSM 24302 = JCM 17472	contig	GCA_001312065	1423802.3	2728369707	1423802	45.03

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
17627	Lactobacillus senioris gene for 16S rRNA, partial sequence	AB602570	1562		1423802
67770	Lactobacillus senioris JCM 17472 gene for 16S rRNA, partial sequence	LC519995	1501		931534

GC content

@ref	GC-content (mol%)	Method
17627	37.9	high performance liquid chromatography (HPLC)
30248	39.8
67770	39.9	genome sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Lentilactobacillus senioris DSM 24302 = JCM 17472
NCBI: GCA_001436555

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	62.80	no
125439	motility	BacteriaNetⓘ	yes	70.00	no
125439	gram_stain	BacteriaNetⓘ	positive	73.50	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Lactobacillus senioris DSM 24302 = JCM 17472
PATRIC: 1423802.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	93.68	yes
125438	anaerobic	anaerobicⓘ	no	85.84	yes
125438	spore-forming	spore-formingⓘ	no	91.95	yes
125438	aerobic	aerobicⓘ	no	96.67	yes
125438	thermophilic	thermophileⓘ	no	95.50	yes
125438	flagellated	motile2+ⓘ	no	90.50	yes

Literature

Topic	Title	Authors	Journal	DOI	Year
	Effects of fermented soymilk with Lacticaseibacillus paracasei YIT 9029 on gut microbiota and defecation habits: a randomised, double-blind, placebo-controlled study.	Kaga C, Nagino T, Gomi A, Takagi A, Miyazaki K, Yoshida Y, Shida K.	Benef Microbes	10.1163/18762891-bja00003	2024
	Structural determination of the cell wall polysaccharide LCPS-1 in Lacticaseibacillus paracasei strain Shirota YIT 9029.	Mizukoshi H, Kimura K, Ikemura H, Mori Y, Nagaoka M.	Carbohydr Res	10.1016/j.carres.2022.108670	2022
	Evaluation of the cariogenic potential of a probiotic candidate strain Lactobacillus gasseri YIT 12321.	Okada A, Imai S, Kikuchi T, Matin K, Otsuka R, Terai T, Okumura T, Yamamoto T, Hanada N.	Arch Oral Biol	10.1016/j.archoralbio.2022.105364	2022
Genetics	Safety assessment of the candidate oral probiotic Lactobacillus crispatus YIT 12319: Analysis of antibiotic resistance and virulence-associated genes.	Terai T, Kato K, Ishikawa E, Nakao M, Ito M, Miyazaki K, Kushiro A, Imai S, Nomura Y, Hanada N, Okumura T.	Food Chem Toxicol	10.1016/j.fct.2020.111278	2020
Metabolism	Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study.	Gomi A, Yamaji K, Watanabe O, Yoshioka M, Miyazaki K, Iwama Y, Urita Y.	J Dairy Sci	10.3168/jds.2017-13803	2018
	Glycophenotyping of mutants of Lacticaseibacillus paracasei by lectin microarray.	Suzuki E, Serata M, Sako T, Sato S, Iino T, Tateno H, Hirabayashi J.	Appl Environ Microbiol	10.1128/aem.01707-24	2025
	Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review.	Mennini M, Piccirillo M, Furio S, Valitutti F, Ferretti A, Strisciuglio C, De Filippo M, Parisi P, Peroni DG, Di Nardo G, Ferrari F.	Front Allergy	10.3389/falgy.2024.1473352	2024
Metabolism	Citrus juice fermented with Lactobacillus plantarum YIT 0132 alleviates symptoms of perennial allergic rhinitis in a double-blind, placebo-controlled trial.	Harima-Mizusawa N, Kano M, Nozaki D, Nonaka C, Miyazaki K, Enomoto T.	Benef Microbes	10.3920/bm2016.0003	2016
Enzymology	Living cells of probiotic Bifidobacterium bifidum YIT 10347 detected on gastric mucosa in humans.	Shibahara-Sone H, Gomi A, Iino T, Kano M, Nonaka C, Watanabe O, Miyazaki K, Ohkusa T.	Benef Microbes	10.3920/bm2015.0138	2016
	The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.	Moludi J, Saber A, Zozani MA, Moradi S, Azamian Y, Hajiahmadi S, Pasdar Y, Moradi F.	Prev Nutr Food Sci	10.3746/pnf.2024.29.3.237	2024
Metabolism	Health benefits of fermented milk containing Bifidobacterium bifidum YIT 10347 on gastric symptoms in adults.	Gomi A, Iino T, Nonaka C, Miyazaki K, Ishikawa F.	J Dairy Sci	10.3168/jds.2014-9158	2015
	Physiological, Pathological, and Circadian Factors Impacting Skin Hydration.	Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN.	Cureus	10.7759/cureus.27666	2022
	Production of angiotensin-I-converting enzyme (ACE) inhibitory activity in milk fermented with probiotic strains: Effects of calcium, pH and peptides on the ACE-inhibitory activity	Gonzalez-Gonzalez CR, Tuohy KM, Jauregi P.	Int Dairy J	10.1016/j.idairyj.2011.04.001	2011
	Detection of Glycolytically Active Lacticaseibacillus paracasei Strain Shirota by Flow Cytometry Targeting the Efflux Activity of Fluorescent Dye: a Potential Tool for Quality Assessment of Probiotic Cells in Milk Products.	Kubota H, Serata M, Matsumoto H, Shida K, Okumura T.	Appl Environ Microbiol	10.1128/aem.02156-22	2023
	Probiotics enhances anti-tumor immune response induced by gemcitabine plus cisplatin chemotherapy for urothelial cancer.	Miyake M, Oda Y, Owari T, Iida K, Ohnishi S, Fujii T, Nishimura N, Miyamoto T, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K.	Cancer Sci	10.1111/cas.15666	2023
	Membrane Emulsification as an Emerging Method for Lacticaseibacillus rhamnosus GG^® Encapsulation.	Camelo-Silva C, Figueredo LL, Cesca K, Verruck S, Ambrosi A, Di Luccio M.	Food Bioproc Tech	10.1007/s11947-023-03099-w	2023
	Side-chain structure of cell surface polysaccharide, mannan, affects hypocholesterolemic activity of yeast.	Yoshida Y, Naito E, Mizukoshi H, Watanabe Y, Kimura K, Yokoi W, Sato T, Okumura T, Ito M, Sawada H.	J Agric Food Chem	10.1021/jf900347q	2009
	Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori.	De Vuyst L, Vincent P, Makras E, Leroy F, Pot B.	Probiotics Antimicrob Proteins	10.1007/s12602-009-9029-4	2010
	Effects of Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota on Constipation in Patients with Depression: A Randomized, Double-Blind, Placebo-Controlled Trial.	Zhang X, Chen S, Zhang M, Ren F, Ren Y, Li Y, Liu N, Zhang Y, Zhang Q, Wang R.	Nutrients	10.3390/nu13072238	2021
	Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota.	Otaka M, Kikuchi-Hayakawa H, Ogura J, Ishikawa H, Yomogida Y, Ota M, Hidese S, Ishida I, Aida M, Matsuda K, Kawai M, Yoshida S, Kunugi H.	Microorganisms	10.3390/microorganisms9051026	2021
	A randomized, double blind, parallel, placebo-controlled study to investigate the efficacy of Lactobacillus paracasei N1115 in gut development of young children.	Wang S, Xun Y, Ahern GJ, Feng L, Zhang D, Xue Y, Ross RP, Doolan AM, Stanton C, Zhu H.	Food Sci Nutr	10.1002/fsn3.2533	2021
	Effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on Japanese cedar pollinosis during probiotic consumption: an open study.	Kakiyama S, Kubota N, Shida K, Harima-Mizusawa N.	Biosci Microbiota Food Health	10.12938/bmfh.2019-017	2020
	[The electron microscopic study of cell-to-cell interactions between antagonistic microorganisms].	Rybal'chenko OV.	Mikrobiologiia	10.1134/s0026261706040187	2006
	Effect of Kluyveromyces marxianus YIT 8292 crude cell wall fraction on serum lipids in normocholesterolemic and mildly hypercholesterolemic subjects.	Yoshida Y, Naito E, Ohishi K, Okumura T, Ito M, Sato T, Sawada H.	Biosci Biotechnol Biochem	10.1271/bbb.60539	2007
	Role of Gastric Microorganisms Other than Helicobacter pylori in the Development and Treatment of Gastric Diseases.	Duan X, Chen P, Xu X, Han M, Li J.	Biomed Res Int	10.1155/2022/6263423	2022
	Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials.	Zeng L, Yang K, He Q, Zhu X, Long Z, Wu Y, Chen J, Li Y, Zeng J, Cui G, Xiang W, Hao W, Sun L.	BMC Med	10.1186/s12916-024-03303-4	2024
	Probiotics-induced changes in gut microbial composition and its effects on cognitive performance after stress: exploratory analyses.	Bloemendaal M, Szopinska-Tokov J, Belzer C, Boverhoff D, Papalini S, Michels F, van Hemert S, Arias Vasquez A, Aarts E.	Transl Psychiatry	10.1038/s41398-021-01404-9	2021
	Effect of Bifidobacterium bifidum fermented milk on Helicobacter pylori and serum pepsinogen levels in humans.	Miki K, Urita Y, Ishikawa F, Iino T, Shibahara-Sone H, Akahoshi R, Mizusawa S, Nose A, Nozaki D, Hirano K, Nonaka C, Yokokura T.	J Dairy Sci	10.3168/jds.2006-803	2007
	Effects of the cell wall of Kluyveromyces marxianus YIT 8292 on the plasma cholesterol and fecal sterol excretion in rats fed on a high-cholesterol diet.	Yoshida Y, Yokoi W, Ohishi K, Ito M, Naito E, Sawada H.	Biosci Biotechnol Biochem	10.1271/bbb.69.714	2005
	Potent hypocholesterolemic activity of the yeast Kluyveromyces marxianus YIT 8292 in rats fed a high cholesterol diet.	Yoshida Y, Yokoi W, Wada Y, Ohishi K, Ito M, Sawada H.	Biosci Biotechnol Biochem	10.1271/bbb.68.1185	2004
	Gastroesophageal Reflux Disease and Probiotics: A Systematic Review.	Cheng J, Ouwehand AC.	Nutrients	10.3390/nu12010132	2020
	Probiotics for the Prevention of Acute Respiratory-Tract Infections in Older People: Systematic Review.	Strauss M, Micetic-Turk D, Pogacar MS, Fijan S.	Healthcare (Basel)	10.3390/healthcare9060690	2021
	Neurogenic Bowel and Management after Spinal Cord Injury: A Narrative Review.	Rodriguez GM, Gater DR.	J Pers Med	10.3390/jpm12071141	2022
Pathogenicity	Partial purification and characterization of the bacteriocin produced by Lactobacillus acidophilus YIT 0154.	Yamato M, Ozaki K, Ota F.	Microbiol Res	10.1078/0944-5013-00190	2003
	Microencapsulation of Lactobacillus casei YIT 9018 using a Microporous Glass Membrane Emulsification System	Song SH, Cho YH, Park J.	J Food Sci	10.1111/j.1365-2621.2003.tb14139.x	2003
	Yogurt, cultured fermented milk, and health: a systematic review.	Savaiano DA, Hutkins RW.	Nutr Rev	10.1093/nutrit/nuaa013	2021
	Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium-host cell crosstalk.	Ishikawa E, Yamada T, Yamaji K, Serata M, Fujii D, Umesaki Y, Tsuji H, Nomoto K, Ito M, Okada N, Nagaoka M, Gomi A.	iScience	10.1016/j.isci.2021.103363	2021
	Biological and Cosmetical Importance of Fermented Raw Materials: An Overview.	Majchrzak W, Motyl I, Smigielski K.	Molecules	10.3390/molecules27154845	2022
	Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy.	Cela L, Brindisi G, Gravina A, Pastore F, Semeraro A, Bringheli I, Marchetti L, Morelli R, Cinicola B, Capponi M, Gori A, Pignataro E, Piccioni MG, Zicari AM, Anania C.	Int J Mol Sci	10.3390/ijms24129781	2023
	Microbiome in atopic dermatitis.	Wollina U.	Clin Cosmet Investig Dermatol	10.2147/ccid.s130013	2017
	Antimicrobial potential of probiotic lactic acid bacteria.	Avonts L, De Vuyst L.	Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet		2001
Pathogenicity	Effects of Synbiotic Supplementation on Chronic Inflammation and the Gut Microbiota in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study.	Kanazawa A, Aida M, Yoshida Y, Kaga H, Katahira T, Suzuki L, Tamaki S, Sato J, Goto H, Azuma K, Shimizu T, Takahashi T, Yamashiro Y, Watada H.	Nutrients	10.3390/nu13020558	2021
	Probiotics as a Tool for Regulating Molecular Mechanisms in Depression: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.	Sikorska M, Antosik-Wojcinska AZ, Dominiak M.	Int J Mol Sci	10.3390/ijms24043081	2023
Metabolism	Production of menaquinones by lactic acid bacteria.	Morishita T, Tamura N, Makino T, Kudo S.	J Dairy Sci	10.3168/jds.s0022-0302(99)75424-x	1999
	Effect of probiotic and prebiotic fermented milk on skin and intestinal conditions in healthy young female students.	Mori N, Kano M, Masuoka N, Konno T, Suzuki Y, Miyazaki K, Ueki Y.	Biosci Microbiota Food Health	10.12938/bmfh.2015-022	2016
	Fermented Food in Asthma and Respiratory Allergies-Chance or Failure?	Debinska A, Sozanska B.	Nutrients	10.3390/nu14071420	2022
	Enhancement of host resistance to bacterial infections in normal and immunosuppressed mice with Actinobacillus suis.	Watanabe T.	Kansenshogaku Zasshi	10.11150/kansenshogakuzasshi1970.70.574	1996
Metabolism	Transcriptomics reveal different metabolic strategies for acid resistance and gamma-aminobutyric acid (GABA) production in select Levilactobacillus brevis strains.	Banerjee S, Poore M, Gerdes S, Nedveck D, Lauridsen L, Kristensen HT, Jensen HM, Byrd PM, Ouwehand AC, Patterson E, Morovic W.	Microb Cell Fact	10.1186/s12934-021-01658-4	2021
	Microencapsulation of Lactobacillus plantarum DKL 109 using External Ionic Gelation Method.	Chun H, Kim CH, Cho YH.	Korean J Food Sci Anim Resour	10.5851/kosfa.2014.34.5.692	2014
	Effect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students: A Randomized, Double-Blind, Placebo-Controlled Trial.	Karbownik MS, Kreczynska J, Kwarta P, Cybula M, Wiktorowska-Owczarek A, Kowalczyk E, Pietras T, Szemraj J.	Nutrients	10.3390/nu12051469	2020
	Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women.	Kano M, Masuoka N, Kaga C, Sugimoto S, Iizuka R, Manabe K, Sone T, Oeda K, Nonaka C, Miyazaki K, Ishikawa F.	Biosci Microbiota Food Health	10.12938/bmfh.32.33	2013
	Effects of oral administration of Lactobacillus casei on antitumor responses induced by tumor resection in mice.	Kato I, Endo K, Yokokura T.	Int J Immunopharmacol	10.1016/0192-0561(94)90116-3	1994
Pathogenicity	Bifidobacteria Prevent Tunicamycin-Induced Endoplasmic Reticulum Stress and Subsequent Barrier Disruption in Human Intestinal Epithelial Caco-2 Monolayers.	Akiyama T, Oishi K, Wullaert A.	PLoS One	10.1371/journal.pone.0162448	2016
	Distribution of TNF endogenously induced by various immunopotentiators and Lactobacillus casei in mice.	Sakagami H, Kuroiwa Y, Takeda M, Ota H, Kazama K, Naoe T, Kawazoe Y, Ichikawa S, Kondo H, Yokokura T.	In Vivo		1992
	Beneficial Effects of Citrus Juice Fermented with Lactobacillus plantarum YIT 0132 on Japanese Cedar Pollinosis.	Harima-Mizusawa N, Iino T, Onodera-Masuoka N, Kato-Nagaoka N, Kiyoshima-Shibata J, Gomi A, Shibahara-Sone H, Kano M, Shida K, Sakai M, Miyazaki K, Ishikawa F.	Biosci Microbiota Food Health	10.12938/bmfh.33.147	2014
	Primary resistance induced in mice by Lactobacillus casei following infection with herpes simplex virus.	Watanabe T, Yamori T.	Kansenshogaku Zasshi	10.11150/kansenshogakuzasshi1970.63.182	1989
	Structural studies of cell wall polysaccharides from Bifidobacterium breve YIT 4010 and related Bifidobacterium species.	Habu Y, Nagaoka M, Yokokura T, Azuma I.	J Biochem	10.1093/oxfordjournals.jbchem.a122188	1987
	Protective effect of lipoteichoic acid from Lactobacillus casei and Lactobacillus fermentum against Pseudomonas aeruginosa in mice.	Setoyama T, Nomoto K, Yokokura T, Mutai M.	J Gen Microbiol	10.1099/00221287-131-9-2501	1985
	Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials.	Harima-Mizusawa N, Kamachi K, Kano M, Nozaki D, Uetake T, Yokomizo Y, Nagino T, Tanaka A, Miyazaki K, Nakamura S.	Biosci Microbiota Food Health	10.12938/bmfh.2015-010	2016
	Role of colony-stimulating activity in antitumor activity of Lactobacillus casei in mice.	Shimizu T, Nomoto K, Yokokura T, Mutai M.	J Leukoc Biol	10.1002/jlb.42.3.204	1987
	[Antitumor activity of Lactobacillus casei YIT 9018 (LC 9018)--effect of administration route].	Yokokura T, Kato I, Matsuzaki T, Mutai M, Satoh H.	Gan To Kagaku Ryoho		1984
	Protection of mice against herpes simplex virus infection by a Lactobacillus casei preparation (LC 9018) in combination with inactivated viral antigen.	Watanabe T, Saito H.	Microbiol Immunol	10.1111/j.1348-0421.1986.tb00926.x	1986
Enzymology	The role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages.	Hashimoto S, Nomoto K, Yokokura T.	Scand J Immunol	10.1111/j.1365-3083.1986.tb02131.x	1986
Biotechnology	Rapid Evaluation and Optimization of Medium Components Governing Tryptophan Production by Pediococcus acidilactici TP-6 Isolated from Malaysian Food via Statistical Approaches.	Lim YH, Foo HL, Loh TC, Mohamad R, Abdul Rahim R.	Molecules	10.3390/molecules25040779	2020
Metabolism	Optimized medium via statistical approach enhanced threonine production by Pediococcus pentosaceus TL-3 isolated from Malaysian food.	Lim YH, Foo HL, Loh TC, Mohamad R, Abdul Rahim R, Idrus Z.	Microb Cell Fact	10.1186/s12934-019-1173-2	2019
	Effects of Lactobacillus casei on Pseudomonas aeruginosa infection in normal and dexamethasone-treated mice.	Saito H, Watanabe T, Horikawa Y.	Microbiol Immunol	10.1111/j.1348-0421.1986.tb00940.x	1986
	Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei.	Nomoto K, Miake S, Hashimoto S, Yokokura T, Mutai M, Yoshikai Y, Nomoto K.	J Clin Lab Immunol		1985
	Induction of tumoricidal peritoneal exudate cells by administration of Lactobacillus casei.	Kato I, Yokokura T, Mutai M.	Int J Immunopharmacol	10.1016/0192-0561(85)90015-3	1985
	Host-mediated antitumor activity of Lactobacillus casei in mice.	Yasutake N, Kato I, Ohwaki M, Yokokura T, Mutai M.	Gan		1984
	[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].	Matsuzaki T, Kato I, Yokokura T, Mutai M.	Gan To Kagaku Ryoho		1984
	Macrophage activation by Lactobacillus casei in mice.	Kato I, Yokokura T, Mutai M.	Microbiol Immunol	10.1111/j.1348-0421.1983.tb00622.x	1983
	Augmentation of mouse natural killer cell activity by Lactobacillus casei and its surface antigens.	Kato I, Yokokura T, Mutai M.	Microbiol Immunol	10.1111/j.1348-0421.1984.tb00672.x	1984
Metabolism	In vitro binding of potent mutagenic pyrolysates to intestinal bacteria.	Morotomi M, Mutai M.	J Natl Cancer Inst	10.1093/jnci/77.1.195	1986
	Comparison of antitumor activity of Lactobacillus casei with other bacterial immunopotentiators.	Yasutake N, Ohwaki M, Yokokura T, Mutai M.	Med Microbiol Immunol	10.1007/bf02123760	1984
	Kinetic modeling, production and characterization of an acidic lipase produced by Enterococcus durans NCIM5427 from fish waste.	Ramakrishnan V, Goveas LC, Halami PM, Narayan B.	J Food Sci Technol	10.1007/s13197-013-1141-5	2015
	Antitumor activity of Lactobacillus casei in mice.	Kato I, Kobayashi S, Yokokura T, Mutai M.	Gan		1981
Enzymology	Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease.	Terai T, Okumura T, Imai S, Nakao M, Yamaji K, Ito M, Nagata T, Kaneko K, Miyazaki K, Okada A, Nomura Y, Hanada N.	PLoS One	10.1371/journal.pone.0128657	2015
Metabolism	Lectin microarray reveals binding profiles of Lactobacillus casei strains in a comprehensive analysis of bacterial cell wall polysaccharides.	Yasuda E, Tateno H, Hirabayashi J, Iino T, Sako T.	Appl Environ Microbiol	10.1128/aem.00240-11	2011
	Brain-gut axis in the pathogenesis of Helicobacter pylori infection.	Budzynski J, Budzynski J, Klopocka M.	World J Gastroenterol	10.3748/wjg.v20.i18.5212	2014
	Optimizing conditions for the growth of Lactobacillus casei YIT 9018 in tryptone-yeast extract-glucose medium by using response surface methodology.	Oh S, Rheem S, Sim J, Kim S, Baek Y.	Appl Environ Microbiol	10.1128/aem.61.11.3809-3814.1995	1995
Enzymology	Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces.	Matsuki T, Watanabe K, Fujimoto J, Takada T, Tanaka R.	Appl Environ Microbiol	10.1128/aem.70.12.7220-7228.2004	2004
	Correlation between increase in Ia-bearing macrophages and induction of T cell-dependent antitumor activity by Lactobacillus casei in mice.	Kato I, Yokokura T, Mutai M.	Cancer Immunol Immunother	10.1007/bf00199932	1988
	Antitumor effect of intrapleural administration of Lactobacillus casei in mice.	Matsuzaki T, Yokokura T, Mutai M.	Cancer Immunol Immunother	10.1007/bf00199931	1988
	Anti-tumour activity of Lactobacillus casei on Lewis lung carcinoma and line-10 hepatoma in syngeneic mice and guinea pigs.	Matsuzaki T, Yokokura T, Azuma I.	Cancer Immunol Immunother	10.1007/bf00199768	1985
Enzymology	Structure of macroamphiphiles from several Bifidobacterium strains.	Iwasaki H, Araki Y, Ito E, Nagaoka M, Yokokura T.	J Bacteriol	10.1128/jb.172.2.845-852.1990	1990
	Prevention of indigenous infection of mice with Escherichia coli by nonspecific immunostimulation.	Nomoto K, Yokokura T, Mitsuyama M, Yoshikai Y, Nomoto K.	Antimicrob Agents Chemother	10.1128/aac.36.2.361	1992
	In vitro and in vivo release of cytostatic factors from Lactobacillus casei-elicited peritoneal macrophages after stimulation with tumor cells and immunostimulants.	Hashimoto S, Nomoto K, Nagaoka M, Yokokura T.	Cancer Immunol Immunother	10.1007/bf00199825	1987
	Anti-tumour effect of humoral and cellular immunities mediated by a bacterial immunopotentiator, Lactobacillus casei, in mice.	Yasutake N, Ohwaki M, Mutai M, Koide Y, Yoshida T.	Cancer Immunol Immunother	10.1007/bf00205676	1985
	Antimicrobial Resistance of Lactic Acid Bacteria from Nono, a Naturally Fermented Milk Product.	Obioha PI, Anyogu A, Awamaria B, Ghoddusi HB, Ouoba LII.	Antibiotics (Basel)	10.3390/antibiotics12050843	2023
Phylogeny	Flavobacterium agri sp. nov., a novel bacterial species isolated from rhizospheric soil of Coriandrum sativum.	Akter S, Lee SY, Moon B, Huq MA.	Arch Microbiol	10.1007/s00203-020-02068-7	2021
Phylogeny	Lentilactobacillus laojiaonis sp. nov., isolated from the mud in a fermentation cellar for the production of Chinese liquor.	Zhao Q, Yang S, Bao G, Wang W, Miao L, Wang S, Shen C, Li Y	Int J Syst Evol Microbiol	10.1099/ijsem.0.005349	2022
Phylogeny	Lentilactobacillus kribbianus sp. nov., isolated from the small intestine of a mini pig.	Bai L, Paek J, Shin Y, Park HY, Chang YH	Int J Syst Evol Microbiol	10.1099/ijsem.0.004560	2020
Phylogeny	Lactobacillus curieae sp. nov., isolated from stinky tofu brine.	Lei X, Sun G, Xie J, Wei D	Int J Syst Evol Microbiol	10.1099/ijs.0.041830-0	2012
Phylogeny	Lactobacillus saniviri sp. nov. and Lactobacillus senioris sp. nov., isolated from human faeces.	Oki K, Kudo Y, Watanabe K	Int J Syst Evol Microbiol	10.1099/ijs.0.031658-0	2011

References

#17627	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 24302
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#26590	IJSEM 601 2012 ( DOI 10.1099/ijs.0.031658-0 , PubMed 21515698 )
#30248	Barberan A, Caceres Velazquez H, Jones S, Fierer N.: Hiding in Plain Sight: Mining Bacterial Species Records for Phenotypic Trait Information. mSphere 2: 2017 ( DOI 10.1128/mSphere.00237-17 , PubMed 28776041 ) - originally annotated from #26590
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lentilactobacillus senioris (DSM 24302, JCM 17472, YIT 12364)

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API 50CHac

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