Klebsiella pneumoniae subsp. pneumoniae (DSM 30102, ATCC 13882, IFO 13541)

Name: Klebsiella pneumoniae subsp. pneumoniae (DSM 30102, ATCC 13882, IFO 13541)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 4958

Type strain

Strain Designation C37, LRA 024 11 73

Culture col. no. DSM 30102 ATCC 13882 IFO 13541 NBRC 13541 NCIB 8267 8 more

NCBI tax ID(s) 72407

Special Collections DSMZ CCUG JCM CIP

Links

Klebsiella pneumoniae subsp. pneumoniae C37 is a mesophilic human pathogen that was isolated from water.

mesophilic human pathogen genome sequence 16S sequence

Name and taxonomic classification

SI-ID 280314

LMG 2950,ATCC 13882,DSM 30102,IFO 13541,LMG 3138,NCIB 8267,NCTC 8172,IAM 12351,CCUG 28450,CIP 103582,NCIMB 8267,CCM 5852,NBRC 13541,JCM 20507

@ref 20215

Last LPSN update 2025-12-16 09:47:57

Domain Pseudomonadati

Phylum Pseudomonadota

Class Gammaproteobacteria

Order Enterobacterales

Family Enterobacteriaceae

Genus Klebsiella

Species Klebsiella pneumoniae subsp. pneumoniae

Full scientific name Klebsiella pneumoniae subsp. pneumoniae (Schroeter 1886) Ørskov 1984

BacDive ID	Other strains from **Klebsiella pneumoniae subsp. pneumoniae** (8)	Type strain
4959	K. pneumoniae subsp. pneumoniae 298-53, 298/53, CCUG 225, NCDC 410-68, DSM ... (type strain)
4953	K. pneumoniae subsp. pneumoniae A3, DSM 9376, ATCC 12657, CDC 383-68, NCIB ...
4954	K. pneumoniae subsp. pneumoniae DSM 9377, ATCC 13887, CDC 421-68, NCTC 9496, ...
4955	K. pneumoniae subsp. pneumoniae C122, DSM 11678, ATCC 33495
4960	K. pneumoniae subsp. pneumoniae DSM 30105, ATCC 9997, CIP 104034, NCDC 400-68
130304	K. pneumoniae subsp. pneumoniae KlpnKS648, KS648, DSM 29417
162705	K. pneumoniae subsp. pneumoniae JCM 20034, ATCC 8308, IAM 1063, IFO 3319, ...
162983	K. pneumoniae subsp. pneumoniae JCM 20694, ATCC 15574, CDC 414-68, IAM 12626

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	99.4
125438	negative	99.5

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
35571	MEDIUM 3 - Columbia agar		Columbia agar (39.000 g);distilled water (1000.000 ml)
9133	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	Medium recipe at MediaDive	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
9133	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
121882	CIP Medium 3	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
9133	positive	growth	37	mesophilic
35571	positive	growth	30	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Spore formation

@ref	Spore formation	Confidence
125439		95.7

Compound production

9133

Compoundbacteriocin

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68368	27613 ChEBI	amygdalin	+	fermentation	from API 20E
68374	29016 ChEBI	arginine	-	hydrolysis	from API ID32E
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
68374	17057 ChEBI	cellobiose	+	builds acid from	from API ID32E
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
68374	18333 ChEBI	D-arabitol	+	builds acid from	from API ID32E
68374	18024 ChEBI	D-galacturonic acid	+	builds acid from	from API ID32E
68374	17634 ChEBI	D-glucose	+	builds acid from	from API ID32E
68368	17634 ChEBI	D-glucose	+	fermentation	from API 20E
68374	16899 ChEBI	D-mannitol	+	builds acid from	from API ID32E
68368	16899 ChEBI	D-mannitol	+	fermentation	from API 20E
68368	5291 ChEBI	gelatin	-	hydrolysis	from API 20E
68374	30849 ChEBI	L-arabinose	+	builds acid from	from API ID32E
68368	30849 ChEBI	L-arabinose	+	fermentation	from API 20E
68374	18403 ChEBI	L-arabitol	-	builds acid from	from API ID32E
68374	62345 ChEBI	L-rhamnose	+	builds acid from	from API ID32E
68368	62345 ChEBI	L-rhamnose	+	fermentation	from API 20E
68374	25094 ChEBI	lysine	+	degradation	from API ID32E
68368	25094 ChEBI	lysine	+	degradation	from API 20E
68374	15792 ChEBI	malonate	+	assimilation	from API ID32E
68374	17306 ChEBI	maltose	+	builds acid from	from API ID32E
68368	28053 ChEBI	melibiose	+	fermentation	from API 20E
68374	17268 ChEBI	myo-inositol	+	builds acid from	from API ID32E
68368	17268 ChEBI	myo-inositol	+	fermentation	from API 20E
68374	18257 ChEBI	ornithine	-	degradation	from API ID32E
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
68374	18394 ChEBI	palatinose	+	builds acid from	from API ID32E
68374		Potassium 5-ketogluconate	-	builds acid from	from API ID32E
68374	15963 ChEBI	ribitol	+	builds acid from	from API ID32E
68374	30911 ChEBI	sorbitol	+	builds acid from	from API ID32E
68368	30911 ChEBI	sorbitol	+	fermentation	from API 20E
68374	17992 ChEBI	sucrose	+	builds acid from	from API ID32E
68368	17992 ChEBI	sucrose	+	fermentation	from API 20E
68374	27082 ChEBI	trehalose	+	builds acid from	from API ID32E
68374	27897 ChEBI	tryptophan	-	energy source	from API ID32E
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68374	16199 ChEBI	urea	+	hydrolysis	from API ID32E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E

Metabolite production

@ref	Chebi-ID	Metabolite
68368	15688 ChEBI	acetoin	from API 20E
68368	16136 ChEBI	hydrogen sulfide	from API 20E
68374	35581 ChEBI	indole	from API ID32E
68368	35581 ChEBI	indole	from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68374	35581 ChEBI	indole		-	from API ID32E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68374	alpha-galactosidase	+	3.2.1.22	from API ID32E
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68374	alpha-glucosidase	-	3.2.1.20	from API ID32E
68374	alpha-maltosidase	-		from API ID32E
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68374	arginine dihydrolase	-	3.5.3.6	from API ID32E
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68382	beta-galactosidase	-	3.2.1.23	from API zym
68374	beta-galactosidase	+	3.2.1.23	from API ID32E
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68382	beta-glucosidase	-	3.2.1.21	from API zym
68374	beta-glucosidase	+	3.2.1.21	from API ID32E
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68374	beta-glucuronidase	-	3.2.1.31	from API ID32E
68382	cystine arylamidase	-	3.4.11.3	from API zym
68368	cytochrome oxidase	-	1.9.3.1	from API 20E
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
68368	gelatinase	-		from API 20E
68374	L-aspartate arylamidase	+	3.4.11.21	from API ID32E
68382	leucine arylamidase	-	3.4.11.1	from API zym
68374	lipase	-		from API ID32E
68382	lipase (C 14)	-		from API zym
68374	lysine decarboxylase	+	4.1.1.18	from API ID32E
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68374	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API ID32E
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
68374	ornithine decarboxylase	-	4.1.1.17	from API ID32E
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
68382	trypsin	-	3.4.21.4	from API zym
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68374	urease	+	3.5.1.5	from API ID32E
68368	urease	+	3.5.1.5	from API 20E
68382	valine arylamidase	-		from API zym

API 20E

@ref	ONPG	ADH (Arg)	LDC (Lys)	ODC	CIT	H2S productionH2S	URE	TDA (Trp)	IND	Acetoin production (Voges Proskauer test)VP	GEL	GLU	MAN	INO	Sor	RHA	SAC	MEL	AMY	ARA	OX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	OF-O	OF-F
9133	+	-	+	-	+	-	+	-	-	+	-	+	+	+	+	+	+	+	+	+	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.
9133	+	-	+	-	+	-	+	-	-	+	-	+	+	+	+	+	+	+	+	+	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
121882	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

API ID32E

@ref	ODC	ADH (Arg)	LDC (Lys)	URE	LARL	GAT	5KG	LipaseLIP	Phenol red (Acidification)RP	beta GLU	MAN	MAL	ADO	PLE	beta GUR	MNT	IND	N-Acetyl-beta-Glucosaminidasebeta NAG	beta GAL	GLU	SAC	LARA	DARL	alpha GLU	alpha GAL	TRE	RHA	INO	CEL	SOR	alpha-MaltosidasealphaMAL	L-aspartic acid arylamidaseAspA
49246	-	-	+	+	-	+	-	-	+	+	+	+	+	+	-	+	-	-	+	+	+	+	+	-	+	+	+	+	+	+	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2
#Environmental	#Aquatic

Isolation

@ref	Geographic location	Country	Country ISO 3 Code	Continent	Isolation date	Sample type
9133						water
49246						Water
67770						Water
121882	London	United Kingdom	GBR	Europe	1950

Taxonmaps

69479

Global distribution of 16S sequence X93214 (>99% sequence identity) for Klebsiella pneumoniae from Microbeatlas

Aquatic Samples	3887
Soil Samples	1141
Animal Samples	41102
Plant Samples	1362
Total Samples	47492

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Pathogenicity animal	Biosafety level	Biosafety level comment
9133			2	Risk group (German classification) According to TRBA 466
121882			2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	NCBI tax ID	Score
66792	ASM1729137v1 assembly for Klebsiella pneumoniae C37	contig	GCA_017291375	573.36618	573	57.03
66792	36734_E01 assembly for Klebsiella pneumoniae NCTC8172	contig	GCA_900451575	573.20119	573	47.94

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Klebsiella pneumoniae gene for 16S rRNA, partial sequence, strain: NBRC 13541	AB680431	1465		573
20218	K.pneumoniae 16S rRNA gene	X93214	1458		573

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Klebsiella pneumoniae C37
NCBI: GCA_017291375

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	95.70	no
125439	motility	BacteriaNetⓘ	yes	76.10	no
125439	gram_stain	BacteriaNetⓘ	negative	99.40	no
125439	oxygen_tolerance	BacteriaNetⓘ	aerobe	86.70	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Klebsiella pneumoniae strain NCTC8172
PATRIC: 573.20119

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	99.50	no
125438	anaerobic	anaerobicⓘ	no	95.76	no
125438	spore-forming	spore-formingⓘ	no	89.83	no
125438	aerobic	aerobicⓘ	no	54.92	no
125438	thermophilic	thermophileⓘ	no	99.50	yes
125438	flagellated	motile2+ⓘ	no	78.84	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	KpSC-ID: a multiplex real-time PCR assay for the simultaneous detection of the Klebsiella pneumoniae species complex and specific identification of Klebsiella pneumoniae, Klebsiella quasipneumoniae and Klebsiella variicola.	McAndrew G, Barbier E, Rodrigues C, Piveteau P, Brisse S, Reddington K.	Microbiology (Reading)	10.1099/mic.0.001587	2025
	Evolution of ceftazidime-avibactam resistance driven by variation in bla _KPC-2 to bla _KPC-190 during treatment of ST11-K64 hypervirulent Klebsiella pneumoniae.	Liu Z, Lei J, Zhang X, Yin J, Zhang Y, Lei K, Geng Y, Huang L, Han Q, He A.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1607127	2025
	A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance.	Chengan K, Hind C, Stanley M, Wand ME, Nagappa LK, Howland K, Hanson T, Martin-Escolano R, Tsaousis AD, Bengoechea JA, Mark Sutton J, Smales CM, Moore SJ.	NPJ Antimicrob Resist	10.1038/s44259-023-00018-z	2023
	Molecular Assessment Using the MASTDISCS® Combi D72C Set for the Phenotypic Detection of Extended-Spectrum Beta-Lactamases, AmpC Beta-Lactamases, and Carbapenemase Enzymes in Escherichia coli and Klebsiella pneumoniae.	Haji SH, Ganjo AR, Abdulaziz SM, Abdullah ZA, Smail SB.	Cureus	10.7759/cureus.77269	2025
Enzymology	Application of UiO-66 MOF for rifampicin removal and post-adsorption antimicrobial activity against MRSA.	Moaty SAA, Kotp AA, Salah AM, Farghali AA, Eldin ZE.	Sci Rep	10.1038/s41598-025-10145-4	2025
	Development of Technology for Providing Antimicrobial Properties to Medical Disposable Masks.	Dubinskaite K, Rubeziene V, Sankauskaite A, Skurkyte-Papieviene V.	Polymers (Basel)	10.3390/polym16213005	2024
	Spices as Sustainable Food Preservatives: A Comprehensive Review of Their Antimicrobial Potential.	Sulieman AME, Abdallah EM, Alanazi NA, Ed-Dra A, Jamal A, Idriss H, Alshammari AS, Shommo SAM.	Pharmaceuticals (Basel)	10.3390/ph16101451	2023
	Synergistic inhibition of ureolytic activity and growth of Klebsiella pneumoniae in vitro suggests cobinding of fluoride and acetohydroxamic acid at the urease active site and provides a novel strategy to combat ureolytic bacteria.	Svane S, Lyngsie MC, Klitgaard JK, Karring H.	Heliyon	10.1016/j.heliyon.2024.e31209	2024
	The potential of wastewater monitoring as a novel surveillance tool for early warning of Bordetella pertussis outbreaks.	Fu S, Du X, Xu Z, Li H, Yao H, Tang S, Zhao W, Hao M, Qiu Z, Wang Z.	Emerg Microbes Infect	10.1080/22221751.2025.2528537	2025
	Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against Klebsiella pneumoniae Isolates.	Ndezo Bisso B, Tokam Kuate CR, Boulens N, Allemann E, Delie F, Dzoyem JP.	Evid Based Complement Alternat Med	10.1155/2022/1936165	2022
Pathogenicity	The neutralizing effect of heparin on blood-derived antimicrobial compounds: impact on antibacterial activity and inflammatory response.	Cont D, Harm S, Schildbock C, Kolm C, Kirschner AKT, Farnleitner AH, Pilecky M, Zottl J, Hartmann J, Weber V.	Front Immunol	10.3389/fimmu.2024.1373255	2024
Metabolism	Analysis of the Metabolic Response of Planktonic Cells and Biofilms of Klebsiella pneumoniae to Sublethal Disinfection with Sodium Hypochlorite Measured by NMR.	Garcia Mendez DF, Rengifo Herrera JA, Sanabria J, Wist J.	Microorganisms	10.3390/microorganisms10071323	2022
	Novel drug candidates against antibiotic-resistant microorganisms: A review.	Lim JS, Chai YY, Ser WX, Haeren AV, Lim YH, Raja T, Foo JB, Hamzah S, Sellappans R, Yow HY.	Iran J Basic Med Sci	10.22038/ijbms.2023.71672.15593	2024
	Thymol and carvacrol against Klebsiella: anti-bacterial, anti-biofilm, and synergistic activities-a systematic review.	Farhadi K, Rajabi E, Varpaei HA, Iranzadasl M, Khodaparast S, Salehi M.	Front Pharmacol	10.3389/fphar.2024.1487083	2024
	Identification of a Depolymerase Specific for K64-Serotype Klebsiella pneumoniae: Potential Applications in Capsular Typing and Treatment.	Li J, Sheng Y, Ma R, Xu M, Liu F, Qin R, Zhu M, Zhu X, He P.	Antibiotics (Basel)	10.3390/antibiotics10020144	2021
	Small Schiff Base Molecules-A Possible Strategy to Combat Biofilm-Related Infections.	Coanda M, Limban C, Nuta DC.	Antibiotics (Basel)	10.3390/antibiotics13010075	2024
	Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.	Brown P, Abdulle O, Boakes S, Divall N, Duperchy E, Ganeshwaran S, Lester R, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ.	ACS Infect Dis	10.1021/acsinfecdis.0c00917	2021
Pathogenicity	Rifampicin conjugated silver nanoparticles: a new arena for development of antibiofilm potential against methicillin resistant Staphylococcus aureus and Klebsiella pneumoniae.	Farooq U, Ahmad T, Khan A, Sarwar R, Shafiq J, Raza Y, Ahmed A, Ullah S, Ur Rehman N, Al-Harrasi A.	Int J Nanomedicine	10.2147/ijn.s198194	2019
	The effect of UV radiation on O-7 Actinomycete in producing bioactive compounds in different growth conditions.	Ibnouf EO.	Saudi J Biol Sci	10.1016/j.sjbs.2021.04.070	2021
	Hypericum Essential Oils-Composition and Bioactivities: An Update (2012-2022).	Grafakou ME, Barda C, Karikas GA, Skaltsa H.	Molecules	10.3390/molecules27165246	2022
	Development of pharmacophore models for AcrB protein and the identification of potential adjuvant candidates for overcoming efflux-mediated colistin resistance.	Behera DU, Gaur M, Sahoo M, Subudhi E, Subudhi BB.	RSC Med Chem	10.1039/d3md00483j	2024
Genetics	Development and proof-of-concept demonstration of a clinical metagenomics method for the rapid detection of bloodstream infection.	Moragues-Solanas L, Le-Viet T, McSorley E, Halford C, Lockhart DS, Aydin A, Kay GL, Elumogo N, Mullen W, O'Grady J, Gilmour MW.	BMC Med Genomics	10.1186/s12920-024-01835-5	2024
Metabolism	Efficient 2,3-butanediol production from whey powder using metabolically engineered Klebsiella oxytoca.	Meng W, Zhang Y, Cao M, Zhang W, Lu C, Yang C, Gao C, Xu P, Ma C.	Microb Cell Fact	10.1186/s12934-020-01420-2	2020
Metabolism	Inhibition of urease activity by different compounds provides insight into the modulation and association of bacterial nickel import and ureolysis.	Svane S, Sigurdarson JJ, Finkenwirth F, Eitinger T, Karring H.	Sci Rep	10.1038/s41598-020-65107-9	2020
Metabolism	The yiaKLX1X2PQRS and ulaABCDEFG gene systems are required for the aerobic utilization of L-ascorbate in Klebsiella pneumoniae strain 13882 with L-ascorbate-6-phosphate as the inducer.	Campos E, de la Riva L, Garces F, Gimenez R, Aguilar J, Baldoma L, Badia J.	J Bacteriol	10.1128/jb.00815-08	2008
	Thymus vulgaris essential oil: chemical composition and antimicrobial activity.	Boruga O, Jianu C, Misca C, Golet I, Gruia AT, Horhat FG.	J Med Life		2014
	A Focused Insight into Thyme: Biological, Chemical, and Therapeutic Properties of an Indigenous Mediterranean Herb.	Hammoudi Halat D, Krayem M, Khaled S, Younes S.	Nutrients	10.3390/nu14102104	2022
Metabolism	Development of a M9-based urea medium (M9U) for sensitive and real-time monitoring of ureolytic activity of bacteria and cell-free urease.	Sigurdarson JJ, Svane S, Karring H.	Microbiologyopen	10.1002/mbo3.976	2020
Enzymology	The detection and verification of carbapenemases using ertapenem and Matrix Assisted Laser Desorption Ionization-Time of Flight.	Johansson A, Ekelof J, Giske CG, Sundqvist M.	BMC Microbiol	10.1186/1471-2180-14-89	2014
Metabolism	DdvK, a Novel Major Facilitator Superfamily Transporter Essential for 5,5'-Dehydrodivanillate Uptake by Sphingobium sp. Strain SYK-6.	Mori K, Niinuma K, Fujita M, Kamimura N, Masai E.	Appl Environ Microbiol	10.1128/aem.01314-18	2018
	Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes.	Marzaman ANF, Roska TP, Sartini S, Utami RN, Sulistiawati S, Enggi CK, Manggau MA, Rahman L, Shastri VP, Permana AD.	Antibiotics (Basel)	10.3390/antibiotics12050822	2023
	In vitro study on the disinfectability of two split-septum needle-free connection devices using different disinfection procedures.	Engelhart S, Exner M, Simon A.	GMS Hyg Infect Control	10.3205/dgkh000260	2015
	Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.	Brown P, Abbott E, Abdulle O, Boakes S, Coleman S, Divall N, Duperchy E, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ.	ACS Infect Dis	10.1021/acsinfecdis.9b00217	2019
Pathogenicity	Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli.	Opperman TJ, Kwasny SM, Kim HS, Nguyen ST, Houseweart C, D'Souza S, Walker GC, Peet NP, Nikaido H, Bowlin TL.	Antimicrob Agents Chemother	10.1128/aac.01866-13	2014
	Development of PCR-based method for detection of Enterobacteriaceae in septicemia.	Fazzeli H, Arabestani MR, Esfahani BN, Khorvash F, Pourshafie MR, Moghim S, Safaei HG, Faghri J, Narimani T.	J Res Med Sci		2012
	Nanoparticles as Potential Novel Therapies for Urinary Tract Infections.	Sanchez SV, Navarro N, Catalan-Figueroa J, Morales JO.	Front Cell Infect Microbiol	10.3389/fcimb.2021.656496	2021
	Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction.	Hasan MR, Tan R, Al-Rawahi GN, Thomas E, Tilley P.	Can J Infect Dis Med Microbiol	10.1155/2014/763128	2014
Pathogenicity	Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.	Williams JD, Nguyen ST, Gu S, Ding X, Butler MM, Tashjian TF, Opperman TJ, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL.	Bioorg Med Chem	10.1016/j.bmc.2013.10.014	2013
Phylogeny	The Pan Genera Detection immunoassay: a novel point-of-issue method for detection of bacterial contamination in platelet concentrates.	Vollmer T, Hinse D, Kleesiek K, Dreier J.	J Clin Microbiol	10.1128/jcm.00542-10	2010
	Identification of RNase 8 as a novel human antimicrobial protein.	Rudolph B, Podschun R, Sahly H, Schubert S, Schroder JM, Harder J.	Antimicrob Agents Chemother	10.1128/aac.00246-06	2006
	Osteoarticular Infection in Three Young Thoroughbred Horses Caused by a Novel Gram Negative Cocco-Bacillus.	Hudson BJ, Chicken C, Blishen A, Todhunter KH, Begg AP, Chan L, Karagiannis T, Raymond B, Bogema D, Adkins AR, O'Sullivan CB, O'Rourke BA, Roy Chowdhury P, Djordjevic SP, Charles IG, Edgar A, Mitsakos K.	Case Rep Vet Med	10.1155/2020/9785861	2020
	Whole-Genome Sequencing and Comparative Genomic Analysis of Antimicrobial Producing Streptococcus lutetiensis from the Rumen.	de Oliveira IMF, Godoy-Santos F, Oyama LB, Moreira SM, Dias RG, Huws SA, Creevey CJ, Mantovani HC.	Microorganisms	10.3390/microorganisms10030551	2022
	Essential Oils as Antimicrobial Agents-Myth or Real Alternative?	Winska K, Maczka W, Lyczko J, Grabarczyk M, Czubaszek A, Szumny A, Szumny A.	Molecules	10.3390/molecules24112130	2019
	Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies.	Shah SR, Shah Z, Khan A, Ahmed A, Sohani, Hussain J, Csuk R, Anwar MU, Al-Harrasi A.	ACS Omega	10.1021/acsomega.9b03314	2019
	Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.	Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M.	J Bacteriol	10.1128/jb.184.9.2439-2446.2002	2002
	Rapid detection of contaminant bacteria in platelet concentrate using differential impedance.	Zhao Z, Chalmers A, Rieder R.	Vox Sang	10.1111/vox.12144	2014
	A new multiplex polymerase chain reaction assay for the identification a panel of bacteria involved in bacteremia.	Fazzeli H, Arabestani MR, Esfahani BN, Khorvash F, Pourshafie MR, Moghim S, Safaei HG, Faghri J, Azimian A.	Adv Biomed Res	10.4103/2277-9175.107972	2013
Metabolism	Influence of Cysteine and Tryptophan Substitution on DNA-Binding Activity on Maize alpha-Hairpinin Antimicrobial Peptide.	Sousa DA, Porto WF, Silva MZ, da Silva TR, Franco OL.	Molecules	10.3390/molecules21081062	2016
Metabolism	Catabolite repression of the citrate fermentation genes in Klebsiella pneumoniae: evidence for involvement of the cyclic AMP receptor protein.	Meyer M, Dimroth P, Bott M.	J Bacteriol	10.1128/jb.183.18.5248-5256.2001	2001
Metabolism	The hpx genetic system for hypoxanthine assimilation as a nitrogen source in Klebsiella pneumoniae: gene organization and transcriptional regulation.	de la Riva L, Badia J, Aguilar J, Bender RA, Baldoma L.	J Bacteriol	10.1128/jb.01022-08	2008
	Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.	Derache C, Labas V, Aucagne V, Meudal H, Landon C, Delmas AF, Magallon T, Lalmanach AC.	Antimicrob Agents Chemother	10.1128/aac.00301-09	2009
	Use of monoclonal antibodies that recognize p60 for identification of Listeria monocytogenes.	Yu KY, Noh Y, Chung M, Park HJ, Lee N, Youn M, Jung BY, Youn BS.	Clin Diagn Lab Immunol	10.1128/cdli.11.3.446-451.2004	2004
	Proof of Principle for a Real-Time Pathogen Isolation Media Diagnostic: The Use of Laser-Induced Breakdown Spectroscopy to Discriminate Bacterial Pathogens and Antimicrobial-Resistant Staphylococcus aureus Strains Grown on Blood Agar.	Multari RA, Cremers DA, Bostian ML, Dupre JM, Gustafson JE.	J Pathog	10.1155/2013/898106	2013
Enzymology	Distribution of coenzyme B12-dependent diol dehydratase and glycerol dehydratase in selected genera of Enterobacteriaceae and Propionibacteriaceae.	Toraya T, Kuno S, Fukui S.	J Bacteriol	10.1128/jb.141.3.1439-1442.1980	1980
Phylogeny	Method for differentiating Klebsiella planticola and Klebsiella terrigena from other Klebsiella species.	Monnet D, Freney J.	J Clin Microbiol	10.1128/jcm.32.4.1121-1122.1994	1994
Phylogeny	Using major outer membrane protein typing as an epidemiological tool to investigate outbreaks caused by milk-borne Campylobacter jejuni isolates in California.	Jay-Russell MT, Mandrell RE, Yuan J, Bates A, Manalac R, Mohle-Boetani J, Kimura A, Lidgard J, Miller WG.	J Clin Microbiol	10.1128/jcm.01845-12	2013
Metabolism	Cloning and expression of Klebsiella pneumoniae genes coding for citrate transport and fermentation.	Schwarz E, Oesterhelt D.	EMBO J	10.1002/j.1460-2075.1985.tb03823.x	1985
Metabolism	Mechanism of Na(+)-dependent citrate transport in Klebsiella pneumoniae.	van der Rest ME, Molenaar D, Konings WN.	J Bacteriol	10.1128/jb.174.15.4893-4898.1992	1992
Phylogeny	Evaluation of autoscan-4 for identification of members of the family Enterobacteriaceae.	Gavini F, Husson MO, Izard D, Bernigaud A, Quiviger B.	J Clin Microbiol	10.1128/jcm.26.8.1586-1588.1988	1988
Pathogenicity	Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.	Stokes NR, Thomaides-Brears HB, Barker S, Bennett JM, Berry J, Collins I, Czaplewski LG, Gamble V, Lancett P, Logan A, Lunniss CJ, Peasley H, Pommier S, Price D, Smee C, Haydon DJ.	Antimicrob Agents Chemother	10.1128/aac.00719-13	2013
Metabolism	Fermentation of 1,2-propanediol with 1,2-ethanediol by some genera of Enterobacteriaceae, involving coenzyme B12-dependent diol dehydratase.	Toraya T, Honda S, Fukui S.	J Bacteriol	10.1128/jb.139.1.39-47.1979	1979
Pathogenicity	Epidemiology of Klebsiella antibiotic resistance and serotypes.	Smith SM, Digori JT, Eng RH.	J Clin Microbiol	10.1128/jcm.16.5.868-873.1982	1982
Enzymology	Detection of Helicobacter pylori in stomach tissue by use of a monoclonal antibody.	Husson MO, Leclerc H.	J Clin Microbiol	10.1128/jcm.29.12.2831-2834.1991	1991
Metabolism	Cyclitol utilization associated with the presence of Klebsielleae in botanical environments.	Talbot HW, Seidler RJ.	Appl Environ Microbiol	10.1128/aem.37.5.909-915.1979	1979
	Significance of fecal coliform-positive Klebsiella.	Bagley ST, Seidler RJ.	Appl Environ Microbiol	10.1128/aem.33.5.1141-1148.1977	1977
Metabolism	Significance of low-temperature growth associated with the fecal coliform response, indole production, and pectin liquefaction in Klebsiella.	Naemura LG, Seidler RJ.	Appl Environ Microbiol	10.1128/aem.35.2.392-396.1978	1978
Enzymology	Incidence and tracking of Escherichia coli O157:H7 in a major produce production region in California.	Cooley M, Carychao D, Crawford-Miksza L, Jay MT, Myers C, Rose C, Keys C, Farrar J, Mandrell RE.	PLoS One	10.1371/journal.pone.0001159	2007
Enzymology	Discovery of novel highly active and stable aspartate dehydrogenases.	Li H, Zhu T, Miao L, Zhang D, Li Y, Li Q, Li Y.	Sci Rep	10.1038/s41598-017-05522-7	2017
Metabolism	Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541.	Okamura T, Noda H, Fukuda S, Ohsugi M.	J Nutr Sci Vitaminol (Tokyo)	10.3177/jnsv.44.483	1998
	Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity.	Guzman JD.	Molecules	10.3390/molecules191219292	2014
Metabolism	Participation of aspartic acid and pyrroloquinoline quinone in vitamin B12 production in Klebsiella pneumoniae IFO 13541.	Ohsugi M, Noda H, Nakao S.	J Nutr Sci Vitaminol (Tokyo)	10.3177/jnsv.39.323	1993
Metabolism	Effects of the yeast extract components pyrroloquinoline quinone and aspartic acid on vitamin B12 production in Klebsiella pneumoniae IFO 13541.	Ohsugi M, Noda H, Muro K, Ishiba A, Kondo Y, Nakao S.	J Nutr Sci Vitaminol (Tokyo)	10.3177/jnsv.35.661	1989
Metabolism	Generation of circularly permuted fluorescent-protein-based indicators for in vitro and in vivo detection of citrate.	Honda Y, Kirimura K.	PLoS One	10.1371/journal.pone.0064597	2013
	Expansion of healthcare-associated hypervirulent KPC-2-producing Klebsiella pneumoniae ST11/KL64 beyond hospital settings.	Esposito F, Cardoso B, Sellera FP, Sano E, Fuentes-Castillo D, Fontana H, Fuga B, Moura Q, Sato MIZ, Brandao CJ, Lincopan N.	One Health	10.1016/j.onehlt.2023.100594	2023
	Establishment and application of a rapid molecular diagnostic platform for the isothermal visual amplification of group B Streptococcus based on recombinase polymerase.	Liu M, Wang H, Chu C, Min F, Sun L, Zhang T, Meng Q.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1281827	2024
	Establishment and application of a point-of-care testing and diagnosis method for early immediate expression gene IE1 of cytomegalovirus in maternal urine based on isothermal amplification.	Chu C, Yu S, Min F, Sun L, Liu M, Meng Q.	Virus Res	10.1016/j.virusres.2023.199229	2023
Phylogeny	Rapid and Accurate Determination of Lipopolysaccharide O-Antigen Types in Klebsiella pneumoniae with a Novel PCR-Based O-Genotyping Method.	Fang CT, Shih YJ, Cheong CM, Yi WC.	J Clin Microbiol	10.1128/jcm.02494-15	2016
Phylogeny	Klebsiella pneumoniae lipopolysaccharide O typing: revision of prototype strains and O-group distribution among clinical isolates from different sources and countries.	Hansen DS, Mestre F, Alberti S, Hernandez-Alles S, Alvarez D, Domenech-Sanchez A, Gil J, Merino S, Tomas JM, Benedi VJ.	J Clin Microbiol	10.1128/jcm.37.1.56-62.1999	1999
	A murine monoclonal antibody defines a unique epitope shared by Klebsiella lipopolysaccharides.	Trautmann M, Vogt K, Hammack C, Cross AS.	Infect Immun	10.1128/iai.62.4.1282-1288.1994	1994
Phylogeny	Comparison of SDS-PAGE protein patterns with other typing methods for investigating the epidemiology of 'Klebsiella aerogenes'.	Costas M, Holmes B, Sloss LL.	Epidemiol Infect	10.1017/s0950268800047464	1990
	Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1.	Whitfield C, Richards JC, Perry MB, Clarke BR, MacLean LL.	J Bacteriol	10.1128/jb.173.4.1420-1431.1991	1991
	Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection.	Rukavina T, Ticac B, Susa M, Jendrike N, Jonjic S, Lucin P, Marre R, Doric M, Trautmann M.	Infect Immun	10.1128/iai.65.5.1754-1760.1997	1997
Phylogeny	Molecular serotyping of Klebsiella species isolates by restriction of the amplified capsular antigen gene cluster.	Brisse S, Issenhuth-Jeanjean S, Grimont PA.	J Clin Microbiol	10.1128/jcm.42.8.3388-3398.2004	2004
Phylogeny	A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera.	Lappan R, Imbrogno K, Sikazwe C, Anderson D, Mok D, Coates H, Vijayasekaran S, Bumbak P, Blyth CC, Jamieson SE, Peacock CS.	BMC Microbiol	10.1186/s12866-018-1154-3	2018
	Virulence for mice of Klebsiella strains belonging to the O1 group: relationship to their capsular (K) types.	Mizuta K, Ohta M, Mori M, Hasegawa T, Nakashima I, Kato N.	Infect Immun	10.1128/iai.40.1.56-61.1983	1983
	Factors promoting survival of bacteria in chlorinated water supplies.	LeChevallier MW, Cawthon CD, Lee RG.	Appl Environ Microbiol	10.1128/aem.54.3.649-654.1988	1988
Phylogeny	Kit systems for identifying gram negative aerobic bacilli: report of the Welsh Standing Specialist Advisory Working Group in Microbiology.	Bennett CH, Joynson DH.	J Clin Pathol	10.1136/jcp.39.6.666	1986
Metabolism	Complementary use of aesculin hydrolysis and inositol fermentation in the characterisation of Klebsielleae.	Barr JG, Mahood RJ.	J Clin Pathol	10.1136/jcp.30.1.45	1977
	O-antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections.	Trautmann M, Ruhnke M, Rukavina T, Held TK, Cross AS, Marre R, Whitfield C.	Clin Diagn Lab Immunol	10.1128/cdli.4.5.550-555.1997	1997
Enzymology	Factors affecting the value of a simple biochemical scheme for identifying Enterobacteriaceae: the reproducible recognition of biotypes.	Barr JG, Mahood RJ, Curry KP.	J Clin Pathol	10.1136/jcp.30.6.495	1977

References

#9133	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 30102
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#35571	; Curators of the CIP;
#49246	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 28450
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68368	Automatically annotated from API 20E .
#68374	Automatically annotated from API ID32E .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#121882	Collection of Institut Pasteur ; Curators of the CIP; CIP 103582
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Klebsiella pneumoniae subsp. pneumoniae (DSM 30102, ATCC 13882, IFO 13541)

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